Cary, North Carolina-based venture capital firm focused on early-stage seed investments in B2B software and related technology in the Southeast, with a particular emphasis on North Carolina. Founded in 2015, the firm partners with entrepreneurs to validate ideas and bring solutions to market, providing capital through its seed program and supporting portfolio companies with a broad adviser and mentor network. Typical investments are in the low hundreds of thousands of dollars, with a preference for minority stakes, and the firm targets software, fintech, healthtech, and other business software sectors.

IDEA Fund Partners is a private equity and venture capital firm founded in 2007 and headquartered in Chapel Hill, North Carolina. It targets early-stage technology companies in North Carolina and the southeastern United States, with investments across technology, software, automation, big data, and healthcare. The firm supports entrepreneurs applying technology and business model innovations to industries facing digital disruption at the earliest stages, with a focus on underserved people, places, and stages.

Hatteras Venture Partners is a Durham, North Carolina-based venture capital and private equity firm founded in 2000 that focuses on funding life sciences and healthcare companies in the United States. Its activities center on biopharmaceuticals, medical devices, diagnostics, healthcare information technology, and related human medicine opportunities, with investments spanning pre-seed to growth stages. The firm typically makes initial investments in the range of half a million to four million dollars and participates in follow-on rounds up to around twenty million, and it operates as a Small Business Investment Company (SBIC). Hatteras also backs adjacent sectors such as software and health services within the Southeast, leveraging an experienced team to support value creation in early-stage biomedical ventures.

VentureSouth is an angel investment group and early-stage venture organization based in Greenville, South Carolina, operating across the Southeastern United States. It develops and manages multiple angel investment groups and funds, drawing more than 550 investors across about a dozen groups, and has deployed over $80 million in more than 100 companies since its inception in 2008 (initially as the Upstate Carolina Angel Network). The organization focuses on startup and early-stage opportunities, particularly in manufacturing, logistics and healthcare sectors, and aims to connect entrepreneurs with capital and strategic support to accelerate growth.

Bull City Venture Partners is a venture capital firm based in Durham, North Carolina, focused on early-stage investments in technology and healthcare companies. The firm targets startups in the Southeast and Mid-Atlantic regions, with a preference for B2B and tech-enabled businesses across software, mobile, e-commerce, health tech, logistics, cloud computing, fintech, and internet services. It backs companies from seed to growth stages, providing capital and strategic support, including governance participation to help accelerate growth and secure follow-on funding. The firm prioritizes innovation and growth potential, partnering with founders to scale operations, expand market reach, and build enduring businesses.

Wilmington Investor Network is an angel investment network based in Wilmington, North Carolina. It mobilizes individual investors to fund early-stage technology, biotechnology, and medical device companies located in eastern North Carolina and nearby South Carolina. Investments typically range from roughly $0.2 million to $0.5 million per round.

Alexandria Venture Investments is the strategic venture capital arm of Alexandria Real Estate Equities. It provides seed through growth capital to life science and technology companies developing breakthrough therapies, diagnostics, research tools, agrifoodtech, agtech, digital health, and related platforms. Backed by the parent company’s industry experience and scientific advisory network, the firm leverages long-standing relationships and domain expertise to support early to growth-stage ventures aiming to translate scientific advances into practical healthcare and technology solutions.

Rex Health Ventures is the corporate venture capital arm of UNC Rex Healthcare, based in Raleigh, North Carolina. Founded in 2012, it targets early-stage investments in healthcare and related technology sectors, including healthcare software as a service, life sciences, and health technology, primarily in the United States. It partners with entrepreneurs and companies to bring innovative products and services to the healthcare marketplace.

SOSV is a global venture capital firm based in Princeton, New Jersey, founded in 1995, that focuses on seed to growth investments in deep technology across health, environmental tech, hardware, robotics, and cross border software, with a particular emphasis on Asia. The company runs accelerator style startup development programs, including HAX and IndieBio, which provide facilities, engineering resources, and lab equipment to help founders accelerate product development, acquire customers, and attract later stage funding. SOSV pursues a limited number of high potential startups, offering extensive hands on support to speed commercialization and scale, and aims to back innovations that improve human and planetary health.

Established in 2021, Pisgah Fund is a venture capital firm headquartered in Asheville, North Carolina. It invests in startups and high-growth companies that offer innovative products or services, focusing on those that enhance regional health and create jobs for Western North Carolina residents.

Oval Park Capital is a venture capital investment firm founded in 2018 and based in Raleigh, North Carolina. It targets investments across a broad range of technology sectors, including advanced materials, agtech, artificial intelligence, automation, robotics, clean tech, climate tech, construction tech, cybersecurity, femtech, fintech, health tech, industrial, infrastructure tech, insurtech, Internet of Things, manufacturing, nanotech, real estate tech, software as a service, supply chain tech, and waste and water tech.

Intersouth Partners is a venture capital firm based in Durham, North Carolina, founded in 1985. It concentrates on seed and early-stage investments in technology and life sciences across the Southeast United States, including software, information technology, semiconductors, digital media, digital health, medical devices, biopharmaceuticals, agricultural biotechnology, and manufacturing. The firm aims to take leadership roles in its portfolio companies, often serving on boards, and focuses on opportunities in the Southeast corridor from Baltimore to Florida, including Washington, DC, the Research Triangle region, and Atlanta.

Triangle Angel Partners is an angel investment group and principal investment firm based in North Carolina that backs early-stage technology, media, telecommunications, software, and life sciences companies. It focuses on opportunities in and around North Carolina’s Research Triangle Park and surrounding Chapel Hill area, and its members provide mentorship and access to a broad network of potential investors, customers, strategic partners, and management talent.

Service Provider Capital is a Colorado-based venture capital firm founded in 2014 that funds seed-stage technology companies across domains such as artificial intelligence, machine learning, blockchain, cybersecurity, fintech, e-commerce, education technology, hardware, robotics, information technology, health tech, and cannabis. The firm also co-invests in Series A rounds led by institutional venture funds, providing capital and guidance to startups in the United States, including the Midwest and Southeast regions.

The Aurora Funds is a North Carolina based venture capital firm established in 1994 and based in Cary, with an additional office in Durham. It historically focused on seed and early-stage investments in healthcare and information technology, including biotechnology, therapeutics, medical devices, healthcare services, and health IT, as well as software, internet infrastructure, data communications, semiconductors, photonics, and nanotechnology. The firm typically invested in seed to Series A rounds, with initial checks around $50,000 to $2.5 million and total commitments of roughly $4-8 million across multiple rounds, often seeking to lead or co-lead and secure a board seat. Its geographic focus centered on the Southeastern and Mid-Atlantic United States, and it pursued dual investments in areas such as healthcare IT and informatics and bio-medical engineering applications. Targeted enterprise values generally ranged from the low to mid tens of millions with EBITDA up to about $75 million. The firm is no longer investing.

Excelerate Health Ventures is a Durham, North Carolina-based venture capital firm founded in 2013 that invests in early‑stage healthcare technology, including healthcare software and digital health solutions, primarily in North America. The firm targets seed and early‑stage opportunities in healthcare and related technology sectors and leverages a network of strategic partners from pharma, providers, and payers to accelerate adoption and revenue for portfolio companies.

Jurassic Capital is a growth equity and venture capital firm based in Durham, North Carolina, that invests in B2B software, SaaS, and technology companies in the Southeast United States. Founded in 2019, it targets companies with annual recurring revenue in the $1–$10 million range and pursues minority and majority stakes to support growth.

Morningside is a Boston-based investment firm founded in 1986 as a family office for the Chan family. It makes venture capital investments in companies with novel science and technology, with deep expertise in life sciences, digital health, artificial intelligence, materials, and technology. The firm takes a long-term approach to building companies and emphasizes ethical conduct. In addition to its investment activities, Morningside supports charitable initiatives in education, research and healthcare, including collaborations with Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Greycroft is a venture capital firm based in New York and Los Angeles that concentrates on technology startups, with a focus on the Internet and mobile markets. The firm uses its extensive media and technology industry connections to help entrepreneurs gain visibility, build strategic relationships, bring products to market, and scale successful businesses. Since inception Greycroft has invested in more than 200 companies and manages over $1 billion in capital. Its investment scope spans consumer internet, fintech, healthcare, and enterprise software, reflecting a broad approach to funding early- and growth-stage ventures in technology sectors.

UNC Kenan-Flagler Private Equity Fund is a student-run private equity fund affiliated with the University of North Carolina at Chapel Hill's Kenan-Flagler Business School. Founded in 2007 and based in Chapel Hill, North Carolina, it engages in private equity and venture capital activities across early and late stages, buyouts, growth capital, mezzanine financing, and real estate investments. The fund targets portfolio company investments of roughly $0.1 million to $0.15 million with enterprise values between $20 million and $125 million and co-invests with partner private investment firms. Operating in an educational setting, it aims to deliver real returns for investors while providing students with hands-on investment experience.

Founded in 1994 and based in Durham, North Carolina, with an office in San Diego, Pappas Capital is a venture capital firm that concentrates on life sciences companies across the United States and Canada, with activities also in Asia. The firm backs early to late-stage ventures in biotechnology, biopharmaceuticals, drug delivery, diagnostics, and medical devices, often serving as lead or co-lead investor. It operates three lines of business: its flagship Pappas Ventures, Specialized Fund Management, and Translational Medicine, through which it partners with research universities to translate scientific discoveries into commercial products. Investments span seed through growth stages, including preclinical companies nearing human trials and those progressing to Phase 3, with a preference for opportunities in California, the Research Triangle area, the East Coast, Texas, Indiana, and Montreal, and a geographic reach that includes Asia. Pappas Capital pursues sizable, strategic stakes and collaborates to accelerate development, occasionally investing alongside co-investors and dedicating capital to early and strategic rounds in life sciences ventures.

Sustainable Food Ventures is a venture capital firm based in Durham, North Carolina, focused on funding early-stage food technology companies developing cell-based, plant-based, and recombinant products.

Founded in 2020 and based in Raleigh, North Carolina, Piedmont Capital Investments is a venture capital firm that invests in transformative science and technology companies, with an emphasis on resilience in American sectors such as electrification, manufacturing, and defense.

One Better Ventures is a Raleigh, North Carolina-based venture capital firm that concentrates on the consumer sector, investing in and supporting mission-driven brands with sustainable business models. The firm advises, invests in, and incubates consumer ventures that aim to deliver positive social or environmental impact, prioritizing principled, patient partnerships and long-term value. Its approach spans working with established and emerging brands to scale responsible consumer products and services, guided by a commitment to service and corporate citizenship. The firm also pursues philanthropy, donating a portion of profits to charity and sharing profits with employees.

CFV Ventures is an early-stage venture capital firm established in 2017 and based in Charlotte, North Carolina. It specializes in investing in companies within the fintech sector, focusing on innovative solutions that address the evolving needs of financial technology. As a part of RevTech Labs, CFV Ventures aims to support and foster growth in emerging fintech businesses, providing not just capital but also strategic guidance to help them navigate the complexities of the financial landscape.

SJF Ventures is a venture capital firm headquartered in Durham, North Carolina, with offices in New York and San Francisco. Founded in 1999, the firm concentrates on growth equity investments in the United States, with a focus on cleantech, sustainability, and technology-enabled services. It backs companies across energy, efficiency, circular economy, logistics, sustainable food, health and education technology, and enterprise software, typically investing 1 to 10 million per portfolio company and often participating in syndicates. SJF seeks teams with scalable models, strong profitability, and potential for rapid sales and premium exits, and often takes board seats to guide strategic growth. The firm emphasizes environmental and social impact alongside financial returns, pursuing opportunities in energy-related impact and climate tech.

Good Growth Capital is a venture capital firm founded in 2015 and based in Charleston, South Carolina. It is a majority women-owned firm that invests in early-stage life sciences, green tech, hard sciences, and data science companies. The firm emphasizes technology commercialization, seeking to fund and grow defensible technologies that address pressing societal needs. It supports early-stage ventures across sectors including pharmaceuticals and biotechnology, software, energy, and materials, aiming to deliver meaningful returns while advancing scientific and technological progress.

Duke Capital Partners is a venture capital firm based in Durham, North Carolina, founded in 2015. It focuses on investing in consumer, enterprise, and life sciences sectors and supports early-stage companies. The firm operates an associate program that educates the next generation of investment professionals and startup founders.

Southern Capitol Ventures was a Raleigh, North Carolina-based venture capital firm that invested primarily in early-stage technology companies in the Southeast and Mid-Atlantic regions, focused on software, e-commerce, digital media, mobile, and healthcare information technology, and pursued opportunities in later-stage investments and spinouts with larger venture funds; it ceased operations and liquidated its funds on December 31, 2024.

Alumshares is a Durham, North Carolina-based technology-enabled investment platform founded in 2017 that enables alumni and other accredited investors to participate in university-related ventures on a syndicated, deal-by-deal basis. It focuses on opportunities connected to universities and invests in breakthroughs in human health, advanced materials, and sustainability.

Sapphire Ventures is a global software-focused venture capital firm that backs technology companies across growth and early stages. With teams in Austin, London, Palo Alto, Menlo Park and San Francisco, it partners with management teams and other venture funds to scale companies toward category leadership. The firm manages a substantial asset base and its portfolio spans software, information technology, fintech, cybersecurity, artificial intelligence, cloud and related technologies. A dedicated Portfolio Growth team provides hands-on support, tools and resources to help portfolio leaders execute growth strategies and scale operations, while Sapphire Ventures also operates platforms such as Sapphire Partners and Sapphire Sport to support portfolio companies and select venture fund initiatives. The firm emphasizes long-term relationships and strategic value creation through its global footprint and operator driven approach.

FJ Labs is a New York-based venture capital firm founded in 2015 by Fabrice Grinda. It is stage-agnostic and focuses on marketplaces and consumer-facing startups, making seed and Series A investments. Typical checks range from 50,000 to 5,000,000 dollars. The firm supports early-stage companies across sectors such as e-commerce, fintech, ad tech, mobile, and software-as-a-service, seeking opportunities with high growth potential in the United States and internationally. Its portfolio includes a mix of consumer brands and marketplace platforms, reflecting an emphasis on business models that connect buyers and sellers or enable direct consumer experiences. FJ Labs aims to back entrepreneurs building scalable, disruptively positioned products and services, often partnering with founders early in their development to help accelerate growth.

Agritech Capital is an investment firm focused on technology and innovation in the agribusiness sector. Founded in 2018 and based in North Wilmington, North Carolina, the firm pursues investments in technology-driven agritech companies across the ecosystem.

Teall Investments, founded by Ben C. Sutton, Jr. in 2017, is a privately held portfolio of investments in innovative lifestyle brands and services with high growth potential. Headquartered in Winston-Salem, North Carolina, with additional offices in Atlanta and San Francisco, Teall Investments is led by a team of experienced executives. The company focuses on partnering with brands that offer unique market opportunities and have the potential for significant growth in the lifestyle sector.

An angel investment group based in Winston-Salem, North Carolina, founded in 2021, that provides seed-stage funding to companies headquartered in or committed to relocating to the greater Winston-Salem area. The organization seeks early-stage ventures with scalable business models and readiness for growth, focusing on sectors including healthcare, information technology, data analytics, apparel, education, virtual reality, automotive technology, and unmanned aviation. Typical investments range from $100,000 to $300,000 and can be in the form of convertible notes or preferred equity; the group may lead, co-lead, or follow in rounds and may request a board seat or observer seat when leading an investment round.

Bootstrap Advisors is a Durham, North Carolina-based venture partner founded in 2015 by three partners who have collaborated for more than a decade. The firm positions itself as hands-on transformers rather than mere incubators or investors, investing their time and own capital to turn ideas into scalable products and companies. They work with entrepreneurs to develop brands and businesses, leveraging a history of starting multiple ventures, scaling several to multi-million-dollar levels and exiting others to strategic buyers. Bootstrap Advisors seeks opportunities across sectors including B2C, information technology, manufacturing, food technology, and software as a service, with a focus on the Southeast United States. The team emphasizes practical support and active involvement to help early-stage concepts reach market success and growth, combining entrepreneurial experience with a disciplined approach to building sustainable businesses.

Southeast Interactive Technology Funds was a venture capital firm founded in 1995 in Research Triangle Park, North Carolina, with an additional office in Redwood City, California. It invested across information technology and communications, including enterprise software, internet infrastructure, and related sectors, spanning early to late stages. The firm managed four funds and supported portfolio companies through sourcing, analysis, financing, growth, and exits, using a proactive, hands on approach aligned with management. It relied on a technical advisory board and venture partners to provide industry, financial, and operational guidance. It built national and global networks of co-investors and limited partners, including strategic and global investors. The firm is now out of business.

Kapstone Medical is a full‑service provider that partners with physician inventors and manufacturers of all sizes to develop and commercialize new medical devices. It offers design, prototyping, patenting, quality systems, and regulatory approvals, as well as product development, quality management, and project management solutions. Its services cover engineering, intellectual property protection, quality assurance, and supply chain management. Based in Charlotte, North Carolina, the company was founded in 2007 by John Kapitan.

Start100 is an accelerator founded in 2017 and based in Charlotte, North Carolina. It invests in startups located in the North Carolina region.

Bioventure Partners is a venture capital firm and growth advisory based in Chapel Hill, North Carolina. It focuses on life sciences and healthcare, investing in early-stage, technology-driven startups and supporting high-impact companies through growth.

Echo Health Ventures is a venture capital firm based in Seattle, Washington, founded in 2016, with offices in Durham, Portland, and Seattle. It invests in healthcare, health technology, insurance technology, and digital health companies across the United States. As a stage-agnostic investor, it aims to accelerate portfolio companies' innovations and help them scale nationally, offering more than capital through deep, high-value relationships and strategic support.

Columbus Nova is an investment firm offering private equity, venture capital and growth equity across multiple sectors. Founded in 2000 and based in New York, with offices in Los Angeles, Charlotte and Menlo Park, it pursues a multi-strategy approach across the capital structure, including growth investments and other private equity transactions. The firm operates Columbus Nova Technology Partners, its technology-focused arm, which targets global growth capital investments in technology companies from bases in Menlo Park and New York. Columbus Nova's activity encompasses consumer products and services, education, entertainment and media, infrastructure and utilities, and seeks long-term value creation and capital preservation.

Salem Investment Partners is a North Carolina-based investment firm founded in 1999 that provides debt and equity capital to privately held mid-market companies. The firm specializes in mezzanine and other forms of financing across sectors including business and healthcare services, light manufacturing, consumer products, and wholesale distribution, and has completed more than 120 investments. Salem is licensed by the U.S. Small Business Administration to participate in the SBIC program, reflecting its role in supporting growth of private companies.

Revolution is a Washington, DC-based venture capital firm that builds and supports regional startup ecosystems through its Rise of the Rest platform. Launched in 2014 to spotlight emerging startup hubs outside New York City, Silicon Valley, and Boston, the firm collaborates with regional ecosystem leaders and co-investors to identify and fund seed- and early-stage companies located outside coastal hubs. Its Rise of the Rest initiative seeks to diversify innovation geography and is supported by a network of iconic entrepreneurs and business leaders. Through Rise of the Rest Seed Fund and related programs, Revolution backs U.S.-based software, services, and technology-enabled startups, helping to scale the next generation of national regional champions.

Next47 is a global independent venture firm backed by Siemens AG that invests in enterprise-focused startup companies leveraging emerging technologies. It pursues fast decision-making and works closely with the teams it backs to unlock maximum potential. The firm leverages Siemens' global footprint and ecosystem spanning multiple industries and regions to support portfolio companies.

First Flight Venture Center is an incubator and venture capital firm based in Durham, North Carolina, founded in 1991. It focuses on early-stage technology and biotechnology companies, primarily those based in or relocating to North Carolina and the Research Triangle Park area. The organization provides early-stage investments typically ranging from about $20,000 to $500,000, along with office and laboratory space, flexible leases, shared business services and equipment, technology support, assistance in obtaining financing, and management guidance to its portfolio companies.

Platform Investment Partners is an investment firm focused on telecoms and technology, with roots in Johannesburg, South Africa and Charlotte, North Carolina. Established in 2016, the firm pursues greenfield opportunities and growth equity investments in the telecoms and technology sectors, delivering capital and strategic support to portfolio companies.

Resilient Ventures is a venture capital firm founded in 2018 and based in Durham, North Carolina. It invests in companies across consumer, technology, consumer products, impact, health, and service sectors, with a mission to disrupt systemic economic injustice by expanding access to capital, networks, and opportunities.

Invaio Sciences is a technology company focused on applying breakthroughs in natural systems and biology to address agriculture, nutrition, and environmental challenges. Headquartered in Cambridge, Massachusetts, with additional locations in Durham, North Carolina; Basel, Switzerland; and São Paulo, Brazil, it develops multi-platform solutions that leverage insights into natural systems and insect physiology to help farmers reduce pesticide use, conserve water, and improve crop health.

Impact Brands is a private investment company and venture capital firm based in Winston-Salem, North Carolina. Founded in 2020, it targets early-stage, founder-led consumer brands and provides backing to opportunities in the retail and services sectors.