OSF Ventures

Cala Health, Inc. is a bioelectronic medicine company based in Burlingame, California, founded in 2013. It specializes in developing wearable neuromodulation therapies aimed at treating chronic diseases. The company's flagship product, Cala Trio, is a non-invasive prescription therapy designed to provide transient relief from hand tremors in adults with essential tremor. By integrating advancements in neuroscience and technology, Cala Health focuses on delivering individualized peripheral nerve stimulation. In addition to its work on essential tremor, the company is also developing therapies for other neurological conditions, including Parkinson's disease, as well as applications in psychiatry, cardiology, and autoimmune disorders.

TailorMed is a health IT company that works with providers, pharmacies and manufacturers to reduce patient financial toxicity and create efficiencies across the patient treatment lifecycle. Our end-to-end platform applies algorithms and automations to make the co-pay assistance and free drug order processes seamless and leverages our deep data set to create actionable insights.

Pieces is a healthcare artificial intelligence and technology company that connects health systems and the community to address clinical and social determinants of health through community networks and intelligent software and services. Our solution interprets patient information in real-time and connects health systems and community-based organizations to support healthier outcomes, both inside and outside of hospital walls. Using cloud-based artificial intelligence with clinically-based natural language processing (NLP) and physician-supervised machine learning, our tools help streamline clinician workflows and improve patient outcomes. Combined, our solutions, Pieces Predict and Pieces Connect, create a comprehensive and unique solution for connected community health.

Huddle Up operates as a pediatric digital health company dedicated to supporting the growth and mental health of children. Founded in 2015 and based in Madison, Wisconsin, the company offers a range of services, including speech therapy, occupational therapy, and mental health support, delivered through live, online interactions. Huddle Up emphasizes personalized care and outcome-driven approaches, partnering with school districts to enhance academic performance and promote social-emotional development. By fostering community, equity, inclusion, and belonging, the company aims to improve overall well-being and encourage healthier lifestyles among children and adolescents.

410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously. This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited. It was founded in 2013 and headquartered in Durham, North Carolina.

Array Behavioral Care, established in 1999 by Geoffrey Boyce in New Jersey, is a leading provider of telepsychiatry services aimed at improving access to quality behavioral health care. The company offers a range of solutions through its divisions: OnDemand Care, Scheduled Care, and AtHome Care, facilitating care from hospitals to patients' homes. Array's services encompass assessment, screening, diagnosis, consultations, and medication management, all designed to be implemented in diverse settings. This innovative approach allows hospitals to deliver convenient and affordable mental health services, enhancing the overall accessibility of behavioral health care for patients.

410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously. This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited. It was founded in 2013 and headquartered in Durham, North Carolina.

Digital Diagnostics Inc. is an artificial intelligence diagnostics company focused on enhancing the quality, accessibility, and affordability of healthcare through advanced technology. Founded in 2010 in Coralville, Iowa, by Michael Abramoff, the company has developed a range of autonomous algorithms that analyze medical images to detect various diseases. Its flagship products include IDx-DR for diabetic retinopathy, IDx-G for glaucoma indicators, and IDx-AMD for age-related macular degeneration. Additionally, Digital Diagnostics provides algorithms for detecting other conditions such as Alzheimer's disease and cardiovascular risks. By eliminating the diagnostic burden from specialists, the company's AI platform aims to establish a new standard of care, democratizing healthcare and improving patient outcomes. The company collaborates with patient advocacy groups and regulatory bodies to facilitate the adoption of its innovative solutions both in the United States and internationally.

Socially Determined, Inc. develops a risk intelligence platform focused on social determinants of health (SDOH). Its primary offering, SocialScape, provides insights into social risks through a combination of social risk indices and visualizations derived from diverse data sources. This platform enables organizations, including health plans, providers, life science companies, and government agencies, to understand the dynamics of social risk and implement actionable programs aimed at enhancing health outcomes while reducing costs. Founded in 2017 and headquartered in Washington, D.C., Socially Determined utilizes secure, cloud-based technology to analyze and visualize community and individual SDOH risks, allowing clients to tailor their intervention strategies to address the specific needs of socially and clinically complex patients.

CancerIQ is a precision health technology company that provides a platform designed to assist healthcare providers in identifying and managing patients at high risk for cancer. The platform features predictive analytics and screening tools to help clinicians detect at-risk patients early. It includes a comprehensive library of evidence-based guidelines and risk models, which aids providers in interpreting data and guiding patients toward appropriate genetic testing, screening, and treatment interventions. Additionally, CancerIQ offers a digital genetic test ordering system and patient management tools, enhancing clinician efficiency and improving patient outcomes by facilitating early cancer detection and adherence to evidence-based care strategies.

Epitel is a digital health company focused on developing a wearable, wireless EEG monitoring platform aimed at improving seizure detection. The company offers a brain health monitoring device that accurately identifies abnormal brain activities using a proprietary cloud-based wearable sensor system combined with advanced artificial intelligence technologies. This innovative approach provides accessible, affordable, and reliable electrographic seizure detection, allowing physicians, caregivers, and patients with neurological disorders to gain valuable insights into brain health. By enhancing the quality of life and care for individuals affected by these conditions, Epitel strives to make significant contributions to the field of digital health.

TailorMed is a health IT company that works with providers, pharmacies and manufacturers to reduce patient financial toxicity and create efficiencies across the patient treatment lifecycle. Our end-to-end platform applies algorithms and automations to make the co-pay assistance and free drug order processes seamless and leverages our deep data set to create actionable insights.

Huddle Up operates as a pediatric digital health company dedicated to supporting the growth and mental health of children. Founded in 2015 and based in Madison, Wisconsin, the company offers a range of services, including speech therapy, occupational therapy, and mental health support, delivered through live, online interactions. Huddle Up emphasizes personalized care and outcome-driven approaches, partnering with school districts to enhance academic performance and promote social-emotional development. By fostering community, equity, inclusion, and belonging, the company aims to improve overall well-being and encourage healthier lifestyles among children and adolescents.

Exela Pharma Sciences, LLC is a rapidly growing US-based specialty pharmaceutical company focused on the development, manufacturing, and marketing of proprietary and generic sterile injectable products. The company aims to improve patient outcomes while reducing overall healthcare costs by offering a range of products, including generic injectables, ophthalmic, and inhalation medications. With a commitment to alleviating drug shortages, Exela is recognized for its dedication to enhancing the supply chain and creating high-value employment opportunities in rural areas. By providing therapeutically effective formulations, Exela increases treatment options for healthcare providers and enhances the quality of life and treatment experience for patients.

Current Health help healthcare reduces risk & cost by monitoring, managing, and engaging patients at home.

Renovia Inc. was a Boston-based healthcare company founded in 2016, focused on developing prescription digital therapeutics for pelvic floor disorders. The company aimed to enhance the lives of women suffering from conditions such as stress, mixed, and urgent urinary incontinence, including overactive bladder. Renovia's innovative device provided a clinically proven, non-surgical, drug-free treatment option, allowing for real-time visualization of pelvic movement during muscle training, thereby facilitating effective therapy. However, in late 2022, Renovia ceased operations following a strategic review by its investors, which included the consideration of a potential sale. In January 2023, most of the company's assets, including its intellectual property, were acquired by Axena Health, Inc.

Recuro Health is a developer of an integrated digital health platform that aims to transform the U.S. healthcare system from a reactive, disease-focused model to one centered on population health and outcomes. The company provides a tailored Digital Medical Home that caters to specific healthcare needs, offering essential virtual care services, including primary care, behavioral health, and urgent care. By equipping employers, providers, and managed care organizations with various digital tools, education, and guidance, Recuro Health enables patients to actively engage in their healthcare through health assessments and interactive communication with professionals, whether via messaging or video. This approach seeks to enhance patient involvement and improve health outcomes across diverse settings.

Huddle Up operates as a pediatric digital health company dedicated to supporting the growth and mental health of children. Founded in 2015 and based in Madison, Wisconsin, the company offers a range of services, including speech therapy, occupational therapy, and mental health support, delivered through live, online interactions. Huddle Up emphasizes personalized care and outcome-driven approaches, partnering with school districts to enhance academic performance and promote social-emotional development. By fostering community, equity, inclusion, and belonging, the company aims to improve overall well-being and encourage healthier lifestyles among children and adolescents.

PhotoniCare, Inc. is a medical device company based in Champaign, Illinois, founded in 2013. The company specializes in developing innovative diagnostic tools for middle ear infections, notably the TOMi Scope. This handheld device employs advanced light-based technology, specifically near-infrared light waves, to create 3D images of the middle ear by seeing through the eardrum. This capability allows physicians to visualize the middle ear directly and safely, enabling them to assess its condition quickly and accurately. By determining the contents of the middle ear, clinicians can make informed decisions regarding the need for antibiotics or surgical interventions. PhotoniCare's technology not only addresses otology but also presents potential for growth in other medical fields.

VIDA is a lung health company focused on modernizing respiratory care through artificial intelligence and advanced data analytics. It empowers healthcare organizations and physicians to enhance patient outcomes, improve care coordination, and drive efficiencies. VIDA's comprehensive software solutions, which are FDA cleared and CE-marked, assist in managing patients with chronic obstructive pulmonary disease, interstitial lung disease, lung cancer, and COVID-19. The company also provides a full suite of clinical trial services, including advanced quantitative image analysis, to strengthen trial data and site quality, as well as subject screening. With a commitment to proven quality and clinical leadership, VIDA aims to accelerate the delivery of new therapies to patients.

SilverCloud Health, founded in 2011 and based in Boston, Massachusetts, specializes in providing evidence-based digital therapies aimed at improving mental wellness. The company offers tailored online therapeutic solutions that address various mental health issues, enhancing overall emotional health. SilverCloud's platform has demonstrated significant success, achieving a three-fold increase in client engagement and a three-fold decrease in program dropout rates compared to leading online therapeutic products. By providing affordable and accessible digital health resources, SilverCloud Health aims to empower users to manage their mental health more effectively.

Health Scholars is a developer of medical simulation training software intended to provide clinical education and training. The company's platform is easy to use and scalable across a health system and effectively manages, delivers and includes interactive training content including the only commercially available as well as clinical VR simulation, enabling users to get cost-effective and richer content experience.

Pieces is a healthcare artificial intelligence and technology company that connects health systems and the community to address clinical and social determinants of health through community networks and intelligent software and services. Our solution interprets patient information in real-time and connects health systems and community-based organizations to support healthier outcomes, both inside and outside of hospital walls. Using cloud-based artificial intelligence with clinically-based natural language processing (NLP) and physician-supervised machine learning, our tools help streamline clinician workflows and improve patient outcomes. Combined, our solutions, Pieces Predict and Pieces Connect, create a comprehensive and unique solution for connected community health.

Socially Determined, Inc. develops a risk intelligence platform focused on social determinants of health (SDOH). Its primary offering, SocialScape, provides insights into social risks through a combination of social risk indices and visualizations derived from diverse data sources. This platform enables organizations, including health plans, providers, life science companies, and government agencies, to understand the dynamics of social risk and implement actionable programs aimed at enhancing health outcomes while reducing costs. Founded in 2017 and headquartered in Washington, D.C., Socially Determined utilizes secure, cloud-based technology to analyze and visualize community and individual SDOH risks, allowing clients to tailor their intervention strategies to address the specific needs of socially and clinically complex patients.

410 Medical has developed a simple, intuitive solution that allows a single healthcare provider to rapidly deliver fluid to critically ill patients, improving care, and saving lives. Their device allows fast set-up, improves resuscitation speed, minimizes provider fatigue, and frees providers to address other patient care issues simultaneously. This solution is particularly useful in pre-hospital settings and the emergency department and where speed is critical and resources may be limited. It was founded in 2013 and headquartered in Durham, North Carolina.

InsightRX is a software platform that incorporates the principles of quantitative pharmacology and machine learning to provide an individualized understanding of a patient’s response to treatment. It delivers its technology in the form of easy-to-use clinical decision support tools at the point-of-care to help guide treatment decision-making. The platform guides treatment decisions at both the individual level and the population level. InsightRX controls clinically validated pharmacokinetic models, patient physiology, pharmacogenomics, drug concentrations, and biomarkers to optimize dosing. It combines real-time patient data and machine learning to understand individual patient pharmacology and inform dose optimization. The platform also leverages disease-based pharmacodynamics models to inform treatment decision making. InsightRX was launched in 2015 by Ron Keizer, Sirj Goswami, and Ranvir Mangat. It is operated from San Francisco, California.

Exo is a medical device startup focused on developing a handheld ultrasound platform for imaging and therapeutic applications. The company aims to provide affordable and user-friendly medical imaging solutions for healthcare professionals globally. By integrating advanced nano-materials, innovative sensor technologies, and sophisticated signal processing with the cost efficiencies of semiconductor manufacturing, Exo significantly lowers the costs associated with medical imaging. This technology allows healthcare providers to make vital, real-time decisions that enhance patient outcomes. Exo's commitment to high-quality, accessible imaging represents a significant advancement in medical technology, making effective diagnostic tools available at an unprecedented price point.

Gauss Surgical, Inc. specializes in real-time blood monitoring solutions that enhance clinical decision-making in the healthcare sector. The company has developed a vision-based platform that provides accurate estimations of blood loss, facilitating timely transfusion decisions and improving patient outcomes. Its flagship product, Triton, is utilized in obstetrics to aid in the early detection of postpartum hemorrhage and offers objective metrics for assessing blood loss. Additionally, Gauss Surgical offers Triton OR, designed for operating rooms to measure blood loss from surgical sponges and suction canisters, and Triton L&D, which focuses on vaginal delivery and postpartum care. Founded in 2011, Gauss Surgical operates from its headquarters in Menlo Park, California.

Endotronix is a developer of hemodynamic monitoring technologies to help detect worsening heart failure earlier than ever before. The company's platform includes a cloud-based disease management data system and outpatient hemodynamic management with a breakthrough implantable wireless pulmonary artery sensor for early detection of worsening heart failure. It was founded in 2007 and is based in Lisle, Illinois.

Renovia Inc. was a Boston-based healthcare company founded in 2016, focused on developing prescription digital therapeutics for pelvic floor disorders. The company aimed to enhance the lives of women suffering from conditions such as stress, mixed, and urgent urinary incontinence, including overactive bladder. Renovia's innovative device provided a clinically proven, non-surgical, drug-free treatment option, allowing for real-time visualization of pelvic movement during muscle training, thereby facilitating effective therapy. However, in late 2022, Renovia ceased operations following a strategic review by its investors, which included the consideration of a potential sale. In January 2023, most of the company's assets, including its intellectual property, were acquired by Axena Health, Inc.

Regroup offers integrated telepsychiatry services that enable remote psychiatric care through live video conferencing. By utilizing advanced encryption technologies, the company ensures patient privacy and the confidentiality of personal health information. Regroup's services enhance access to mental health care, allowing patients to overcome challenges such as geographic distances, mobility restrictions, transportation issues, and the associated time and cost burdens of in-person visits.

Level Ex, Inc. is a Chicago-based company that develops virtual surgery mobile applications aimed at enhancing the skills of physicians through immersive training experiences. The company offers a platform called Virtual Technique Guides, which leverages cloud gaming technology to facilitate interactive surgical training. This platform allows surgeons to perform virtual procedures alongside medical device sales representatives in a web conferencing environment. Additionally, Level Ex has developed Airway EX, an app tailored for mastering critical endoscopic and interventional airway procedures. This application addresses various medical scenarios, including managing obstructing tumors, vocal cord injuries, and complex intubations in both adult and pediatric patients. Founded in 2015, Level Ex combines video game technology and cognitive neuroscience to provide physicians with tools to navigate rare medical cases, new medical devices, and evolving drug therapies.

PatientWisdom, LLC is a digital health company based in New Haven, Connecticut, established in 2015. It specializes in a software-as-a-service (SaaS) platform that captures and curates patient stories to enhance healthcare delivery. The platform provides three key solutions: PatientWisdom, which helps healthcare providers understand patients' priorities before clinical encounters; ProviderWisdom, which gathers insights from clinicians to create more responsive healthcare ecosystems; and CommunityWisdom, which offers a comprehensive view of community needs to inform the development and partnership of relevant health programs. By engaging with patients, providers, and community members, PatientWisdom aims to improve the overall healthcare experience and address challenges such as clinician burnout. The company has been recognized for its innovative approach, receiving accolades as a leading tech startup and for its patient-centered focus in various industry competitions.

Regroup offers integrated telepsychiatry services that enable remote psychiatric care through live video conferencing. By utilizing advanced encryption technologies, the company ensures patient privacy and the confidentiality of personal health information. Regroup's services enhance access to mental health care, allowing patients to overcome challenges such as geographic distances, mobility restrictions, transportation issues, and the associated time and cost burdens of in-person visits.

InsightRX is a software platform that incorporates the principles of quantitative pharmacology and machine learning to provide an individualized understanding of a patient’s response to treatment. It delivers its technology in the form of easy-to-use clinical decision support tools at the point-of-care to help guide treatment decision-making. The platform guides treatment decisions at both the individual level and the population level. InsightRX controls clinically validated pharmacokinetic models, patient physiology, pharmacogenomics, drug concentrations, and biomarkers to optimize dosing. It combines real-time patient data and machine learning to understand individual patient pharmacology and inform dose optimization. The platform also leverages disease-based pharmacodynamics models to inform treatment decision making. InsightRX was launched in 2015 by Ron Keizer, Sirj Goswami, and Ranvir Mangat. It is operated from San Francisco, California.

AVIA Inc. is a digital transformation partner for healthcare organizations, founded in 2012 and based in Chicago, Illinois. The company specializes in developing a knowledge-sharing and collaboration platform that offers market intelligence, collaborative tools, and results-based consulting services. AVIA aims to address the strategic challenges faced by healthcare providers by facilitating access to a network of health systems and strategic partners. Their platform allows healthcare leaders to research, evaluate, and select digital health solutions, while also engaging with expert consultants to guide them through the digital transformation process. This comprehensive approach enables healthcare enterprises to innovate and achieve digital success effectively.

Endotronix is a developer of hemodynamic monitoring technologies to help detect worsening heart failure earlier than ever before. The company's platform includes a cloud-based disease management data system and outpatient hemodynamic management with a breakthrough implantable wireless pulmonary artery sensor for early detection of worsening heart failure. It was founded in 2007 and is based in Lisle, Illinois.

BrightWater Medical, Inc. is a medical device company focused on providing innovative solutions for interventional radiologists, particularly in the treatment of ureteral blockages. Founded by Dr. Bob Smouse, a highly regarded expert in interventional radiology, the company has developed the ConvertX Stent, a device that allows for the conversion from a catheter to a nephroureteral stent without requiring a second invasive procedure. This innovation streamlines the treatment process, enabling doctors to manage more patients effectively while reducing the complexities of care. Established in 2014 and based in Mountain View, California, BrightWater Medical operates as a subsidiary of Merit Medical Systems, enhancing its capabilities in addressing biliary and urinary blockages.

Pieces is a healthcare artificial intelligence and technology company that connects health systems and the community to address clinical and social determinants of health through community networks and intelligent software and services. Our solution interprets patient information in real-time and connects health systems and community-based organizations to support healthier outcomes, both inside and outside of hospital walls. Using cloud-based artificial intelligence with clinically-based natural language processing (NLP) and physician-supervised machine learning, our tools help streamline clinician workflows and improve patient outcomes. Combined, our solutions, Pieces Predict and Pieces Connect, create a comprehensive and unique solution for connected community health.

Health Catalyst is a technology company that specializes in data and analytics solutions for healthcare organizations. The company offers a platform that organizes, normalizes, and links health-related data from various systems, making it accessible and searchable for all users, including those without technical expertise. Health Catalyst operates through two main segments: the Technology segment, which generates the majority of its revenue through cloud-based subscriptions, time-based licenses, and maintenance fees for its data platforms and analytics applications; and the Professional Services segment, which provides a range of services including analytics, implementation, strategic advisory, and outsourcing to help clients optimize their use of the technology. By integrating and analyzing healthcare data, Health Catalyst aims to enhance decision-making and improve outcomes in the healthcare sector.

Euphrates Vascular is a medical technology company based in St. Louis, Missouri, focused on developing innovative solutions for the treatment of stroke, heart disease, and other related conditions. The company's flagship product, the magnetically-enhanced diffusion (MED) system, employs advanced magnet-based technology to accelerate the dissolution of blood clots, offering a faster delivery of FDA-approved clot-busting medications compared to traditional methods. This technology aims to significantly reduce mortality rates associated with strokes and heart disease. In addition to the MED system, Euphrates Vascular offers MED MicroBeads, which facilitate the rapid delivery of selected therapeutic agents to blood clots, and a touch screen-operated MED Workstation for enhanced user interaction. Founded by physicists with extensive experience in medical technology, the company continues to attract interest from investors and media for its groundbreaking contributions to cardiovascular care.