Cultivation Capital is a St. Louis–based private equity and venture capital firm focusing on early-stage investments in life sciences, healthcare, software and information technology, agriculture technology, and geospatial sectors in the United States. Founded in 2012, the firm backs companies from seed through Series B rounds, providing capital and strategic guidance to help portfolio companies grow. Cultivation Capital operates as an investment adviser.

Advantage Capital Partners is a private equity and venture capital firm founded in 1992 and headquartered in New Orleans, with offices across the United States. It specializes in equity and debt investments, including growth equity, senior debt, mezzanine debt, and subordinated loans, focusing on small businesses and underserved communities to drive local economic development. The firm targets companies at various growth stages in sectors such as manufacturing, technology, business services, energy, agriculture, and renewables, and also participates in rural and minority-led ventures. Its strategy combines debt and equity financing, often supporting ventures with capital needs from roughly half a million up to several million dollars, and it collaborates with state and federal programs to extend financing. Known for impact investing, Advantage Capital aims to create jobs and broad-based economic growth by investing in communities with limited access to traditional risk capital.

Missouri Technology Corporation is a venture capital firm and public-private partnership established by the Missouri General Assembly to stimulate entrepreneurship and the growth of high-tech companies across Missouri. It focuses on technology-driven and life sciences ventures, leveraging Missouri's agricultural heritage to support innovation. The organization provides funding programs alongside ecosystem support and resource navigation to help entrepreneurs develop and scale technology-based businesses, aiming to drive sustainable economic growth in the state. Through initiatives such as the IDEA Fund Program, MOBEC Grant Program, and Physical Infrastructure Grant Program, MTC offers capital and strategic assistance to early-stage ventures and tech firms throughout Missouri.

BioGenerator is the non-profit venture development organization of BioSTL, based in St. Louis, Missouri, that supports the creation and growth of bioscience startups in the St. Louis region. It provides early-stage companies with pre-seed and seed funding, shared laboratory space with specialized equipment, and in-depth management support to help turn scientific ideas into sustainable businesses. As BioSTL’s venture arm, BioGenerator often leads or co-leads investments in early-stage ventures and coordinates with local angel groups and other capital to enable follow-on funding. Its focus spans bioscience sectors such as healthcare, plant sciences, medical devices and diagnostics, information technology for life sciences, and related research tools, with the aim of accelerating translation of research and contributing to regional economic growth.

St. Louis Arch Angels is a network of accredited investors based in St. Louis, Missouri, focused on seed, startup and early-stage capital in the Saint Louis region. The group funds and supports high-potential ventures drawn from the local startup ecosystem, including universities, research institutes, companies and technology incubators, to advance regional innovation. Investments are typically made through member contributions, with individual investments between $25,000 and $100,000 and group investments from $250,000 to $750,000, with an investment horizon of up to eight years. The Arch Angels complement the region's financing options along the seed to later-stage continuum and address funding gaps underserved by institutional venture firms.

KCRise Fund is a Kansas City, Missouri-based venture capital firm focused on early-stage investments in the Kansas and western Missouri region. Founded in 2016 as part of the KCRising initiative to build regional capacity, scale existing businesses, and realize the area’s potential, the firm concentrates on technology and business software, including SaaS, information technology, and sectors such as supply chain/logistics, digital health, govtech, and human resources tech, while also pursuing opportunities in B2B, energy, financial services, and healthcare. It partners with other institutional investors and invests alongside them to support growth in local companies. The firm manages about $70 million in committed capital, reflecting its role in developing the Kansas City area’s startup ecosystem.

Lewis & Clark Ventures is a Saint Louis, Missouri-based venture capital firm that partners with ambitious founders to build B2B software, fintech, and digital health companies. It focuses on late seed through Series A investments, providing entrepreneurial support, guidance, and resources to help portfolio companies scale and achieve sustainable growth, with a long-term, collaborative approach across its investments in the technology and healthcare sectors.

Serra Ventures is a venture capital investment firm based in Champaign, Illinois. It backs technology companies at early stages and beyond, with a focus on information technology, deep tech, instrumentation, devices, software-as-a-service, B2B software, and agricultural technologies. The firm primarily targets opportunities in the Midwest and West Coast, investing in companies across the United States and select international locations.

iSelect Fund is a venture capital firm based in Saint Louis, Missouri, that invests in agriculture, food tech, and healthcare sectors. It focuses on early-stage companies, including seed, Series A and B rounds, with a preference for opportunities in the U.S. Midwest, Southeast and Great Lakes regions, as well as in India. The firm targets companies in plant sciences, seed genetics, sustainability, immunotherapy, and personalized medicine, and typically seeks to invest at least $50,000, aiming for a multi-year horizon of approximately five to seven years.

Prolog Ventures is a Missouri-based venture capital firm providing early-stage and growth capital to startups in life sciences, healthcare, and related consumer wellness sectors across North America. It backs companies developing products, technologies and innovative business models in areas such as nutrition, personal care, functional foods and beverages, medical foods, dietary supplements, home care and consumer health solutions, with emphasis on proprietary ingredients, formulations and delivery technologies. The firm focuses on opportunities in life sciences, healthcare and fast-moving consumer goods that aim to improve health and well-being for people and companion animals worldwide.

The Yield Lab is a venture capital firm and accelerator focused on agtech and agrifood tech. Founded in 2014 in Saint Louis, Missouri, it supports early-stage startups through equity investments and accelerator programs. The firm targets technologies across crops, animal health, digital agriculture, logistics, food ingredients, and related areas such as energy and climate tech. It maintains a global network with regional operations in Latin America, Europe, and Asia Pacific, enabling investments across North America, Europe, Latin America and Asia Pacific. The Yield Lab seeks to advance sustainable agriculture and food systems by nurturing innovative companies from inception through scale.

SixThirty is a venture capital firm based in Saint Louis, Missouri, founded in 2013. It invests in early-stage FinTech, InsurTech, and cybersecurity companies, typically seed to Series A, and supports approximately 8–12 portfolio companies each year with funding, mentorship, and connections. The firm operates a go-to-market program and an accelerator to help startups scale, working with corporate investors and partners to mentor and grow the businesses. Its investment focus spans wealth and asset management, payments, insurance, healthcare, core processing, cyber security, fraud and privacy, regulatory and compliance, and risk management, with a global reach across markets.

Established in 2018, Lightchain Capital is a venture capital firm headquartered in Saint Louis, Missouri. It specializes in investing in early-stage companies within the life sciences sector, with a focus on improving outcomes for cancer patients.

Arsenal Capital Management is a venture capital investment firm founded in 2012 and based in Saint Louis, Missouri. It focuses on investing in growth companies.

Dundee Venture Capital is a venture capital firm based in Omaha, Nebraska, with additional offices in Chicago, Minneapolis, Boulder and Saint Louis. It focuses on seed and post-seed technology investments across the United States and Canada, including B2B SaaS, consumer networks, Internet services, web services, e-commerce, fintech and digital health, and typically makes initial commitments in the low hundreds of thousands to a few million dollars. The firm seeks board positions or observer rights in early rounds and aims to support portfolio companies through growth, with exits planned over several years.

RiverVest Venture Partners is a U.S.-based venture capital firm founded in 2000 and headquartered in Saint Louis, Missouri, with offices in Cleveland and San Diego. The firm concentrates on early-stage investments in life sciences, notably biopharmaceuticals and medical devices, and also pursues select later-stage opportunities to diversify risk. Its activities focus on healthcare devices and supplies, pharmaceuticals, biotechnology, life sciences, and oncology, applying domain expertise to identify, shape, and accelerate promising companies. RiverVest provides strategic leadership and practical advice to entrepreneurs to advance early-stage ventures and aims to create shareholder value. The firm operates as a registered investment adviser.

Royal Street Ventures is a venture capital and private equity firm headquartered in Park City, Utah, with an additional office in Kansas City, Missouri. It concentrates on early-stage investments across technology and technology-enabled sectors, including health and wellness, transportation and logistics, action sports, cybersecurity, data, education, specialty manufacturing, fintech, specialty chemicals, consumer goods, and pet care. The firm targets opportunities in the Mountain West, Midwest, Pacific Northwest, and California, often taking board seats to provide ongoing direction for portfolio companies. Initial checks typically range from about $100 to $1 million, with rounds from $0.75 million to $5 million. By backing founders in under-capitalized markets, Royal Street Ventures aims to help build scalable companies with regional and national reach.

Synchrony Bio is a venture capital firm based in Saint Louis, Missouri, founded in 2018. It focuses on early-stage investments in biomedical, medical device, and life sciences ventures, supporting portfolio companies through initial development and value creation. The firm aims to mitigate risk and accelerate product development and market readiness by providing capital and strategic guidance to early-stage startups in its core life sciences sectors.

Evergy Ventures is the corporate venture capital arm of Evergy, based in Kansas City, Missouri, established in 2015. It makes growth and early-stage investments in the energy sector, supporting companies across the energy value chain, including energy storage, mobility, grid modernization and planning, AI, customer energy solutions, energy infrastructure, energy marketing, environmental remediation, infrastructure security, and renewables services. It typically uses equity and debt instruments and pursues opportunities in North America, with a focus on Midwest-based companies.

Kingdom Capital is an investment firm engaged in venture capital and private equity activities. Founded in 2016 and based in Chesterfield, Missouri, it targets early- and growth-stage opportunities in healthcare, medical, and technology sectors, including artificial intelligence, data science, therapeutics, medical devices, diagnostics, healthcare IT, and life science tools. The firm operates a platform that connects values-driven investors with its portfolio opportunities and philanthropic partners, supporting initiatives through its Kingdom Capital Foundation. Through this integrated approach, Kingdom Capital aims to advance innovation at the intersection of healthcare and technology while building sustainable value for its stakeholders.

Mid-America Angels is a regional network of accredited investors that identifies and funds early-stage companies. It participates in seed, Series A, and Series B rounds depending on the capital raise and provides a framework to pool the members’ knowledge, experience, and investment capital. Founded in 2006, the organization is based in Kansas and Oklahoma and focuses on the Kansas-Missouri region around Kansas City, typically investing between $250,000 and $1,500,000 per opportunity.

American Outdoor Brands is a manufacturer of outdoor and firearms products serving hunting, fishing, camping, shooting, personal security and defense markets. The company designs and produces a broad range of gear, including shooting supplies, rests and vaults; premium knives and tools for fishing and hunting; land management tools for hunting preparedness; harvesting and post-hunt products; electro-optical devices such as hunting optics, firearm aiming devices, flashlights and laser grips; reloading, gunsmithing and firearm cleaning supplies; and survival, camping and emergency preparedness products. It sells through e-commerce and traditional distribution channels under the Marksman, Defender, Harvester and Adventure brands. The business is headquartered in Columbia, Missouri.

Redbud VC is a venture capital firm founded in 2023 and based in Columbia, Missouri. It positions itself as a generalist technology investor that backs founders strengthened by adversity, supporting companies from first checks to pre-seed rounds. The firm emphasizes an Operator DNA—seasoned builders who have scaled companies from zero to billions—and provides substantial hands-on support, including introductions to investors, customers, and talent. Redbud highlights a diverse portfolio, with 61% of founders being first-time entrepreneurs, 45% immigrants, and 48% rooted in the Midwest. Through its network, the firm averages more than 20 introductions for portfolio companies in the first six months and has helped 44 portfolio companies raise over $150 million. The firm concentrates on fostering growth in the Midwest and beyond, aiming to be a responsive, direct operator partner that helps technology startups scale rapidly.

Lagomaj Capital is a venture capital firm based in Saint Louis, Missouri, founded in 2017. It pursues investments across information technology, digital health, life sciences, and big data, spanning seed, early-stage, and later-stage opportunities. The firm supports entrepreneurs with fundraising guidance, networking assistance, and strategic consultation to help turn ideas into scalable companies. Lagomaj emphasizes a results-driven approach and seeks ambitious, visionary partners to advance growth and innovation.

Nidus Partners is a venture capital firm based in Saint Louis, Missouri, focused on seed and early-stage investments in technology and energy. It targets the energy sector, including renewables, energy efficiency, energy conversion, storage, biomass conversion, bioconversion, and carbon capture technologies, and backs innovations such as biofuels, gasification, bioelectrochemical conversion, predictive modeling, and renewable biochemicals.

Augury Capital Partners is a venture capital firm based in Saint Louis, Missouri, founded in 2006. It concentrates on mid- to late-stage growth investments in life sciences and related IT sectors, including pharmaceutical, biotechnology, medical devices, and financial services information technology. The firm also pursues expansion capital and arbitrage opportunities, with a preference for revenue-generating companies that have positive cash flow or are expected to achieve cash flow within 12 months. Its geographic focus includes the Midwest, the Southern United States, and Europe, and it targets opportunities in underserved venture markets.

Freedom 3 Capital is a New York-based investment firm founded in 2013 that targets the lower mid-market in North America. It provides debt and equity structures to support growth, strategic initiatives, and the needs of family-owned businesses, using an engineer's approach to building sound financial structures. The firm emphasizes active engagement with management and ownership to align objectives, manage risk, and create upside opportunities. It operates with a systematic approach to sourcing and underwriting and maintains offices in New York and Kansas City. Its investment focus spans business and consumer services, telecommunications and technology, and industrials.

Armstrong Teasdale is a law firm established in 1901 and headquartered in Saint Louis, Missouri. It provides a broad range of legal services, including litigation and dispute resolution, intellectual property, environmental law, corporate services, mergers and acquisitions, bankruptcy, private equity and venture capital, and marijuana and hemp law. The firm serves clients across sectors such as aerospace and defense, technology, life sciences, healthcare, real estate, media, and financial services, delivering client-focused service and strong results in both the boardroom and the courtroom.

Established in 2018, Cure8 Ventures is an early-stage investment firm headquartered in Saint Louis, Missouri. It specializes in investing within the food, healthcare, and wellness sectors.

FINTOP Capital is a venture capital firm based in Nashville, Tennessee, founded in 2016. It concentrates on investing in B2B software-as-a-service and software companies in the FinTech space, with a focus on B2B FinTech and vertical SaaS platforms that have a proven product, real revenues, and leadership drawn from the industries they serve. The firm also maintains offices in Hoboken, New Jersey, and St. Louis, Missouri.

Founded in 2022, Iyengar Capital Partners is a venture capital firm based in Clayton, Missouri, focused on healthcare and life sciences, investing in companies in medical devices and healthcare services, and partnering with entrepreneurs who are transforming healthcare through clinical innovation.

Countdown Capital is a Columbia, Missouri-based venture capital firm founded in 2020 that concentrates on early-stage investments in industrial companies, with a focus on aerospace, manufacturing, defense, energy, and construction sectors.

Stadia Ventures is a Saint Louis, Missouri-based venture capital firm and sports- and esports-focused accelerator. Founded in 2015, it concentrates on startups in sports, esports, and related areas such as lifestyle and recreation, performance and wellness, fan engagement and experience, media and entertainment, esports, and sports betting. It operates a sports business accelerator that selects 4-6 startups twice a year, investing around 100,000 per company and guiding founders through a 14-week bootcamp with mentors and opportunities to connect with potential clients. Stadia Ventures has expanded its operations to Frisco, Texas, and has a portfolio of about 40 companies with several exits and ongoing fundraising by portfolio firms.

Stonehenge Capital is a national specialty finance firm providing long-term capital through private equity, tax credit, and structured finance. Since 1990 its principals have funded privately held businesses across the United States, and the firm, formed in 1999 by former Banc One Capital Markets leaders, manages several private equity and mezzanine funds with more than $500 million in capital. With offices across multiple states, Stonehenge targets growth and expansion in sectors including manufacturing, distribution, business services and healthcare, and it participates in community development through New Markets Tax Credit allocations and related lending. The firm concentrates on mezzanine and equity investments in designated communities, aiming to support distressed areas and generate positive local impact.

OCA Ventures is a Chicago-based venture capital firm established in 1999 that focuses on early-stage technology investments in the United States and Canada. It backs companies in software, fintech, digital health, consumer software, and enterprise software, with a preference for scalable technology-enabled businesses in information technology and related sectors. The firm seeks to partner with startups in the United States and Canada, supporting growth in sectors such as software, digital health, fintech, and business services through early-stage funding.

Mercury Fund is a Houston-based venture capital firm founded in 2005 that invests in early-stage technology companies, including software, fintech, healthcare, energy, and manufacturing. It emphasizes capital-efficient businesses and provides operational support through a collaborative approach to help founders achieve product growth and go-to-market success. The firm typically leads Seed and Series A rounds and pursues opportunities beyond Silicon Valley, focusing on the U.S. midcontinent and underserved regions.

Fulcrum Global Capital is a Kansas City-based venture capital firm that backs disruptive companies in the agriculture supply chain, agtech, food production, food safety, food waste, and animal health. Founded in 2016, the firm leverages deep industry experience to help portfolio companies grow through strategic connections and active board participation. It primarily invests in post-seed opportunities with a view to long-term growth, aiming for sustainable expansion and strong returns.

S2G Investments is a Chicago-based venture capital firm focused on scaling companies across food and agriculture, oceans, and energy. Established in 2014, it pursues multi-stage investments—from seed to growth—aimed at transforming food systems, sustainable energy resources, and related infrastructure. The firm seeks market-driven solutions that improve value and performance compared with traditional options, supporting entrepreneurs and leadership teams to deliver enhanced outcomes while advancing environmental and human health objectives and a sustainable blue economy. Its portfolio targets sectors including agriculture, ingredients, infrastructure and logistics, food safety and technology, retail and restaurants, and consumer brands, with a priority on healthy, sustainable, and locally sourced food products and services.

Prelude Ventures is a San Francisco based venture capital firm that invests in early-stage startups focused on mitigating climate change and building category-defining businesses. The firm targets opportunities across built environment, carbon management, computing, energy, food and agriculture, manufacturing, industrials, mobility, and related sectors, supporting portfolio companies with capital and practical expertise to scale climate solutions.

M25 is a Chicago-based venture capital firm focused on the Midwest, founded in 2015 by Victor Gutwein and Mike Asem. It invests in pre-seed and seed-stage technology startups headquartered in the Midwest and has backed a large portfolio across multiple cities and states in the region. The firm emphasizes an analytical approach and collaborative partnership with founders to support growth, aiming to be a key participant in the Midwest startup ecosystem across various technology sectors.

Service Provider Capital is a venture capital firm established in 2014 and based in Golden, Colorado, with operations in Vail, Colorado. The firm co-invests in Seed and Series A rounds led by institutional venture funds and maintains six regional funds covering Rocky Mountain and View regions across Midwest, New England, Southeast, Texas, and the Pacific Northwest. It has a portfolio of more than 600 companies and a network of over 400 strategic investors, connecting portfolio companies to potential investors, customers, and partners. Service Provider Capital emphasizes timely support and accessibility, covering its own legal fees to expedite processes and offering investment terms that avoid restrictive rights. It operates as an independent entity not affiliated with its portfolio companies.

Leaps by Bayer is the corporate venture capital arm of Bayer, founded in 2015 and based in Leverkusen, Germany. It invests in paradigm-shifting advances in the life sciences, focusing on biotechnology, agriculture, and scientific breakthroughs to accelerate transformative biotechnologies. The unit seeks innovations that could redefine healthcare by moving beyond treating symptoms toward cures or prevention and contribute to sustainable agriculture, aiming to deliver meaningful, broad-scale impact for society.

Jump Capital is a Chicago-based venture capital firm founded in 2012 that concentrates on early-stage investments across financial services, fintech, software, infrastructure, and related technology sectors in the United States. The firm pursues a founder-focused, low-ego partnership approach and backs startups in areas such as healthcare, information technology, the Internet of Things, e-commerce, marketing technology, artificial intelligence, big data, cybersecurity, gaming, and other tech-enabled markets.

Linseed Capital is an angel investment and venture capital firm based in Omaha, Nebraska, focused on funding startups in Nebraska and the Midwest. It invests both independently and as a member of The Nebraska Angels, and it actively mentors entrepreneurs while supporting the regional ecosystem through involvement in events and programs such as Big Omaha and the Pipeline Entrepreneur Fellowship. The firm emphasizes thorough due diligence, strong leadership, and long‑term value creation across diverse sectors.

Sierra Ventures is a San Mateo, California-based venture capital firm founded in 1982 that focuses on early-stage investments in Next Generation Enterprise and Emerging Technologies. The firm primarily backs Seed and Series A rounds, often taking a lead role and reserving capital for follow-ons. It targets B2B technology companies across enterprise software, AI/ML, big data, cloud infrastructure, fintech, health tech, IoT, cybersecurity, and other frontier technologies such as 5G, robotics, blockchain, and virtual/augmented reality. Typical initial checks range from $500,000 to $7 million, with total investment up to $15 million over the life of a company. Sierra Ventures emphasizes board involvement when leading a round and leverages a broad network of entrepreneurs, CXOs, and domain experts to support portfolio companies. With over two decades in the Bay Area and more than $2 billion in assets under management, the firm operates globally while maintaining a strong North American focus.

Uncorrelated Ventures is an early‑stage venture capital firm that specializes in infrastructure software and adjacent technology sectors, including decentralized finance, cryptocurrency, blockchain, fintech, and data infrastructure. Founded in 2019 and headquartered in San Francisco, it backs early‑stage companies whose products underpin programmable networks and modern finance. The firm has built a portfolio of more than 100 companies across traditional and decentralized ecosystems, reflecting a focus on infrastructure‑driven innovations that enable scalable, secure technology platforms.

IDI Group is a European private equity investor focused on supporting the growth of small and mid-sized companies across France, Europe and emerging economies. The firm targets equity investments typically ranging from about €25 million to €100 million through leveraged buyouts and growth capital, with flexibility to take majority or minority stakes and opportunities for co-investments. It partners with management teams to align interests and offers bespoke value-adding support, including access to an expert network and M&A assistance. With more than five decades of experience, IDI Group manages roughly €850 million in small- and mid-cap investments and operates independently, pursuing opportunities in sectors such as e-commerce, education, software, SaaS and healthcare. The firm’s approach emphasizes long-term growth and close collaboration with portfolio companies to drive expansion across its core markets.

Hard Yaka is an investment firm based in Crystal Bay, Nevada. It engages in private equity and venture investments, focusing on technology and financial services sectors, including early-stage investments in exchange-related startups and opportunities in buyouts and distressed assets, often pursuing majority stakes.

FM Capital is a venture firm focused on transforming the transportation industry by partnering with entrepreneurs developing innovative, cleaner, safer, and more efficient mobility solutions for moving people and goods. It invests in automotive technology, transportation, and mobility companies across the automotive and mobility landscape, leveraging a proprietary sourcing process and hands-on management engagement to drive long-term portfolio performance. The firm seeks both strong financial returns and positive social impact through advances in safer vehicles, reduced emissions, and more equitable access to mobility.

McKesson Corporation is a global healthcare company that provides medicines, pharmaceutical supplies, information and care management products and services across the healthcare system. It supports hospitals, pharmacies and providers with distribution, technology-enabled services and clinical resources to improve medication management and care delivery. Through its medical-surgical unit, it distributes medical supplies and healthcare solutions, and it offers services that support pharmacy operations and care management across the supply chain.