Founded in 2012, Cultivation Capital is a venture capital firm based in Saint Louis, Missouri. The firm focuses on early-stage investing in life sciences, health technology, software, IT, agriculture tech, and geospatial tech sectors.

Advantage Capital Partners is a United States‑based venture capital firm that provides growth equity, debt, and mezzanine financing to small and mid‑market companies, with a focus on underserved communities and state and local economic development. The firm invests across sectors including manufacturing, technology, business services, life sciences, and energy, and also supports real estate development projects with equity and debt. It typically makes initial investments ranging roughly from half a million to ten million in companies with modest sales, and may participate in larger follow‑on rounds or co‑invest with other firms. It uses senior debt, mezzanine debt, subordinated loans, and government‑guaranteed lending, and often pursues equity positions through preferred shares or convertible notes. Advantage Capital operates nationwide in the United States, with roots in New Orleans and offices in multiple states, and has backed thousands of jobs and housing projects as part of its mission to expand inclusive economic growth.

Founded in 2005, Missouri Technology Corporation is a venture capital firm based in Jefferson City, Missouri. It invests in early-stage companies located within the state, focusing on industries such as life sciences, animal health, applied engineering, biomedical science, defense & homeland security, plant science, and technology.

BioGenerator is the venture development organization of BioSTL that supports bioscience startups in the St. Louis region. It provides pre-seed and seed investments, access to shared laboratory space with specialized equipment, and comprehensive management support to help form and grow bioscience companies. The organization often acts as a lead investor in early-stage deals and collaborates with local angel groups and venture funds to enable follow-on funding. Founded in 2003 and based in St. Louis, BioGenerator focuses on healthcare, plant sciences, medical devices, diagnostics, agriculture, and related bioscience sectors.

St. Louis Arch Angels is an angel investment group focused on providing seed, startup, and early-stage capital primarily within the St. Louis region. Established in January 2005 and based in St. Louis, Missouri, the group invests between $25,000 and $100,000 per individual transaction, with collective investments ranging from $250,000 to $750,000. The organization aims to support high-potential startups from the local ecosystem, thereby enhancing the region's capacity to finance innovation. St. Louis Arch Angels seeks to fill the funding gap often overlooked by institutional venture capital firms, retaining investments for up to eight years to foster the growth and success of their portfolio companies.

Serra Ventures is a venture capital firm based in Champaign, Illinois, that invests in technology companies across the United States and select international locations. The firm concentrates on early-stage and growth opportunities in information technology, deep technology, instrumentation, software as a service, devices, B2B, and agricultural technologies, with a focus on the Midwest and West Coast regions. Serra Ventures supports portfolio companies through strategic guidance, networks, and resources to help scale technology-enabled businesses.

Founded by Darcy Howe in 2016, KCRise Fund is a venture capital firm based in Kansas City, Missouri. It invests alongside other institutional investors in early-stage companies located in Kansas and the western half of Missouri. The fund focuses on sectors such as software, TMT, B2B products/services, energy, financial services, healthcare, and information technology.

Founded in 2015, Lewis & Clark Ventures is a St. Louis-based venture capital firm focusing on early-stage investments in B2B software and healthcare technology sectors. They aim to be a trusted partner for entrepreneurs, supporting them in scaling their businesses.

Founded in 2014, The Yield Lab is a global venture capital firm focused on early-stage investments in AgriFood Tech. It invests in innovative technologies across crops, animal health, digital agriculture, logistics, and food ingredients, with initial investments ranging from $100,000 to $1.5 million.

Prolog Ventures is a Missouri-based venture capital firm established in 2000 that backs early-stage and growth companies in life sciences, healthcare, and consumer wellness. It targets opportunities in traditional healthcare, nutrition, personal care, household care, and related information technology, as well as green technology and diagnostics, with emphasis on fast-moving consumer goods markets such as functional foods, dietary supplements, medical foods, and home care products. The firm focuses on companies with proprietary ingredients, formulations, and delivery technologies, and typically invests in North American opportunities.

iSelect Fund Management is a venture capital firm based in Saint Louis, Missouri that pursues early-stage and growth investments across the United States, Canada, Europe and other markets. The firm targets opportunities in healthcare, software, agriculture and life sciences, including areas such as plant sciences, seed genetics, sustainability, immunotherapy, personalized medicine, consumer health and food technology. It typically backs seed and Series A or B rounds and aims for multi-year investment horizons. While it maintains a broad geographic scope, it emphasizes sectors with global growth potential and supports startups positioned to address food, health and scientific innovation on a regional and international scale.

SixThirty is a global venture capital fund specializing in early-stage investments in financial technology (FinTech), insurance technology (InsurTech), and cybersecurity startups. It invests globally, typically providing $0.1-$0.25 million in equity per company. SixThirty operates an 8-week business development program and aims to support 8-14 startups annually.

Established in 2018, Lightchain Capital is a venture capital firm headquartered in Saint Louis, Missouri. It specializes in investing in early-stage companies within the life sciences sector, with a focus on improving outcomes for cancer patients.

Dundee Venture Capital, established in 2010, is a venture capital firm headquartered in Omaha, Nebraska, with additional offices in Chicago, Minneapolis, and Saint Louis. The firm specializes in investing in early-stage technology companies, focusing on B2B SaaS, e-commerce, fintech, and supply chain technology sectors. Dundee typically invests between $0.25 million to $1 million in initial rounds, with a potential follow-on investment, and seeks board positions or observer roles. The firm's investment focus is on underserved capital markets across the United States, with a typical exit timeline of six to eight years. Dundee Venture Capital does not invest in companies requiring government approval for operation, such as those in bio, pharma, or life sciences sectors.

Arsenal Capital Management is a venture capital investment firm based in Saint Louis, Missouri. Founded in 2012, the firm specializes in investing in growth companies, aiming to support their expansion and development. Through its investment strategies, Arsenal Capital Management seeks to identify and nurture businesses with significant potential for growth.

Founded in 1956, Hermann Companies is a diversified investment firm based in Saint Louis, Missouri. They focus on venture-stage and middle-market companies operating across various sectors including technology, manufacturing, real estate, light manufacturing, packaging, distribution, business-to-business technology, and financial services technology.

Fulcrum Global Capital is a venture capital firm based in Kansas City, Missouri. Founded in 2016, it focuses on investing in companies operating in agriculture, agtech, food production, food safety, food waste, and animal health.

Prosper Women Entrepreneurs, established in 2012 and based in Saint Louis, Missouri, is an early-stage venture firm dedicated to fostering women-led businesses. It achieves this by operating a startup accelerator program, aiming to enhance women entrepreneurs' access to growth capital and encourage more women to invest in early-stage markets.

Firebrand Ventures is a venture capital firm founded in 2016 and based in Kansas City, Missouri, with additional offices in Austin and Boulder. It concentrates on early-stage investments in software and technology startups, with a preference for companies in the United States and Canada and for opportunities arising in communities underserved by traditional venture capital. The firm supports early-stage companies as they scale, focusing on software and technology sectors.

A venture capital and private equity firm founded in 2012, headquartered in Park City, Utah, with an office in Kansas City, Missouri. It focuses on early‑stage investments in technology and technology‑enabled startups, as well as retail, consumer goods, and health and wellness, primarily in the Mountain West, Midwest, Pacific Northwest, and California. The firm typically invests between $0.1 million and $1 million in seed and early rounds ranging from $0.75 million to $5 million, and takes director seats to help shape boards. It targets under‑capitalized markets and seeks to provide strategic guidance to its portfolio companies.

Synchrony Bio is a venture capital firm founded in 2018 and based in Saint Louis, Missouri. It focuses on early-stage investments in biomedical, medical device, and life sciences companies, providing funding and venture development support to help portfolio companies advance their programs and reduce development risk.

Mid-America Angels is a business angel group founded in 2006 and headquartered in Fairway, Kansas, with additional offices in Lenexa and Lawrence, Kansas. The organization focuses on funding start-up and early-stage companies primarily in the Kansas-Missouri region and within a 150-mile radius of Kansas City. It engages a network of accredited investors to identify and finance opportunities, typically participating in seed, Series A, and Series B funding rounds. Mid-America Angels aims to invest between $250,000 and $1,500,000 in promising ventures, and may consider investments outside its primary geographic area in collaboration with other angel networks or investment organizations. The group's structure allows it to leverage the collective knowledge, experience, and capital of its members to support the growth of emerging businesses.

Boeing HorizonX is a venture capital firm established in 2017 that focuses on investing in innovative startups worldwide. Its investment team leverages a diverse range of expertise from Boeing and broader market experience to identify and support revolutionary concepts. By providing funding to selected startups, HorizonX connects them with Boeing's extensive global resources, facilitating the development and realization of their ideas. The firm operates with a global presence, with teams located in various cities, including Chicago, Menlo Park, Los Angeles, Seattle, St. Louis, Washington D.C., and Israel.

Kingdom Capital is a venture capital firm established in 2016, headquartered in Chesterfield, Missouri. It focuses on investing in early-stage, growth-stage, and mature companies across healthcare, technology, media, and real estate sectors.

Founded in 1999, OCA Ventures is a Chicago-based venture capital firm focusing on early-stage investments primarily in technology and highly-scalable services businesses. The firm's investment focus areas include digital health, fintech, consumer software, and enterprise software.

RiverVest Venture Partners is a venture capital firm focused on early-stage life science investments in the United States. Headquartered in St. Louis, Missouri, it maintains offices in Cleveland and San Diego and pursues opportunities in biopharma and medical device sectors. The firm operates as a registered investment adviser.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

American Outdoor Brands specializes in designing and manufacturing a wide range of outdoor products and accessories for enthusiasts engaged in hunting, fishing, camping, shooting, and personal security. The company's offerings include shooting supplies, knives and tools for outdoor activities, land management tools, harvesting products, electro-optical devices, reloading supplies, and survival gear. American Outdoor Brands focuses on delivering innovative, high-quality products through its Marksman, Defender, Harvester, and Adventure brand lanes.

Redbud VC is a venture capital firm founded in 2021 and headquartered in Columbia, Missouri. It supports early-stage technology founders by providing financial capital and access to networks, mentorship, and strategic guidance to help with product development, customer acquisition, and scaling.

Sofia Fund is an angel group and venture capital firm based in Minnesota that backs women-led, technology-based startups at the early stage. It focuses on information technology and managed services, business products and services, health and wellness, and clean technology, investing in areas such as software, data management, e-commerce, materials and energy efficiency. The firm typically provides small initial investments in one or two rounds and supports portfolio companies toward profitable exits within a few years. Its main office is in Minneapolis, reflecting a regional focus on founder-led ventures with diverse leadership.

Founded in 2017, Lagomaj Capital is a venture capital firm based in Saint Louis, Missouri. It focuses on investing in seed, early-stage, and later-stage companies within the information technology, digital health, life sciences, and big data sectors.

FINTOP Capital, established in 2016, is a venture capital firm based in Nashville, Tennessee, with additional offices in Hoboken, New Jersey, and St. Louis, Missouri. The firm specializes in investing in early-stage, B2B service-enabled SaaS and software companies operating in the FinTech sector. FINTOP Capital targets companies with a proven product, real revenues, and leadership teams composed of industry veterans.

Founded in 2006, Augury Capital Partners is a private equity firm specializing in mid and late-stage investments. It focuses on companies operating in life sciences, financial IT, medical devices, biopharmaceuticals, and transaction processing sectors across the Midwest, Southern United States, and Europe.

Armstrong Teasdale is a law firm established in 1901 and headquartered in Saint Louis, Missouri. It provides a broad range of legal services, including litigation and dispute resolution, intellectual property, environmental law, corporate services, mergers and acquisitions, bankruptcy, private equity and venture capital, and marijuana and hemp law. The firm serves clients across sectors such as aerospace and defense, technology, life sciences, healthcare, real estate, media, and financial services, delivering client-focused service and strong results in both the boardroom and the courtroom.

Abstraction Capital, established in 2020 and headquartered in Kansas City, Missouri, is an early-stage venture capital firm. It specializes in investing in pre-seed or seed rounds for software companies developing technical tools, APIs, and infrastructure that enhance developer productivity and streamline software workflows. The firm's portfolio includes companies building open-source tools, low-code platforms, and solutions for software observability and DevOps.

Founded in 2015, Stadia Ventures is a venture capital firm focused on sports and esports industries. Based in St. Louis with operations expanded to Frisco/Dallas, the company invests in early-stage startups, providing them with business development bootcamps, mentorship, and networking opportunities.

Established in 2010, Nidus Partners is a venture capital firm headquartered in St. Louis, Missouri. It focuses on investing in innovative energy technologies.

Established in 2018, Cure8 Ventures is an early-stage investment firm headquartered in Saint Louis, Missouri. It specializes in investing within the food, healthcare, and wellness sectors.

Founded in 2020, Countdown Capital is an investment firm focused on early-stage industrial companies. It primarily invests in sectors such as aerospace, manufacturing, defense, energy, and construction.

Founded in 2020, Broadview Group focuses on investing in and scaling businesses within niche manufacturing, specialty distribution, industrial services, and food & agribusiness sectors. They target United States-based companies with attractive long-term growth dynamics.

Growth Street Partners is a San Francisco-based private equity and venture capital firm that provides early-stage and growth capital to technology-enabled companies, with a focus on software-as-a-service and related SaaS-enabled services. Founded in 2016, the firm invests across the United States and typically targets investments in the range of $3 million to $10 million, often in companies with annual revenues between $1 million and $5 million. The firm emphasizes scalable software and technology-enabled services opportunities and supports growth and expansion initiatives across the U.S.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Prospect Capital Corporation is a publicly traded business development company that provides flexible private debt and equity capital to sponsor-owned and non-sponsor-owned middle-market companies in the United States and Canada. It originates and manages a range of investments, including secured and unsecured term loans, mezzanine debt, private debt and equity, and real estate investments (notably multifamily housing). It supports growth, acquisitions, recapitalizations and restructurings, often through sponsor-backed transactions as well as direct lending to owner-operated businesses. The firm targets middle-market opportunities across industries, with a history of financing across energy, industrials, and other sectors, and pursues both primary origination and secondary loan portfolios. It aims to deliver steady, attractive returns to shareholders by providing capital across the capital structure and leveraging a diversified investment approach.

Leaps by Bayer is the corporate venture capital arm of Bayer. Established in 2015 and headquartered in Leverkusen, Germany, it invests in life sciences, including healthcare, biotechnology, and agriculture. The firm seeks long-term, disruptive technologies and supports innovations with potential for significant societal impact.

Jump Capital is a venture capital firm founded in 2012 and based in Chicago and New York. It pursues seed and Series A investments through a thesis-led, sector-focused, operating-centric approach, backing data-driven technology companies across FinTech, B2B software-as-a-service, IT and data infrastructure, media, and related areas in the United States. The firm seeks partners with experienced management teams and provides an operating platform and resources to support growth. Initial investment checks typically range from 2 million to 10 million. Jump Capital emphasizes practical, hands-on involvement and aims to align with entrepreneurs seeking a trusted partner with real-world operating experience.

Morningside is a venture capital firm based in the greater Boston area, specializing in investments in companies that focus on innovative science and technology. Established in 1986 as a family office for the Chan family, Morningside emphasizes a long-term approach to company-building and maintains a strong commitment to ethical practices. The firm is staffed by a team of experienced investment professionals with expertise in various sectors, including life sciences, digital health, artificial intelligence, materials, and technology. In addition to its investment activities, Morningside is dedicated to philanthropic efforts, supporting education, research, and healthcare initiatives such as the Harvard T.H. Chan School of Public Health, UMass Chan Medical School, and the MIT Morningside Academy for Design.

Samsung Venture Investment Corporation is the corporate venture arm of Samsung Electronics, founded in 1999 and based in Seoul. It maintains a global presence with activity in innovation hubs such as the San Francisco Bay Area, Boston, London, Tel Aviv, Bangalore, Tokyo, and Beijing, and it backs emerging technology startups across Europe, Asia, and North America. The firm sources and invests in technology companies at multiple stages, from early-stage to pre-IPO, focusing on areas including semiconductors, materials, mobile services, internet, software, security, and enterprise solutions, as well as bioengineering and medical tech. Its investment approach targets companies developing AI, robotics, augmented and virtual reality, cybersecurity, 5G, next generation displays, battery technology, digital health, and insurtech, among others, to support shaping future technologies.

Founded in 2012, SternAegis Ventures is a venture capital firm based in New York. It specializes in early-stage and emerging growth companies within the technology, telecom, media, internet, and life sciences industries.

S2G Ventures is a Chicago-based, multi-stage investment firm focused on fostering innovation across food and agriculture, oceans, and energy. Founded in 2014, it targets late-stage venture and growth investments and maintains a portfolio spanning seed, venture, and growth rounds. The firm backs entrepreneurs delivering market-driven solutions that transform food systems and related sectors, including ingredients, infrastructure and logistics, food safety technology, retail and consumer brands, as well as opportunities in ocean and energy domains. Its objective is to catalyze healthier, sustainable, and locally sourced food systems through investments that cover agricultural products, logistics, and consumer offerings.

Founded in 1982, Sierra Ventures is a Bay Area-based early-stage venture capital firm investing globally with a focus on Next Generation Enterprise and Emerging Technologies. With over $2 billion under management, it has invested in leading companies such as Intuit and Invensense.