St. Louis Arch Angels

Maximum Fidelity Surgical Simulation specializes in the development of advanced medical training solutions, focusing on the creation of hyper-realistic surgical simulators. Their flagship product is a human-like mechanical cadaver system designed to enhance medical education by accurately mimicking human anatomy and physiological responses. This system employs realistic materials and technologies, such as Simblood and a pulsatile pump, to replicate blood flow and circulatory functions. By offering an immersive training environment, Maximum Fidelity enables medical personnel to practice surgical techniques and trauma care without the ethical concerns associated with using live subjects. The company's innovative approach is applicable across various fields, including military trauma training, biomedical device testing, and veterinary education, ensuring that learners gain critical hands-on experience in a safe and controlled setting.

SentiAR, Inc. is a digital health company based in St. Louis, Missouri, specializing in 3D augmented reality solutions for interventional medical procedures. Founded in 2017 as a spin-off from Washington University, SentiAR has developed a platform that offers real-time holographic visualization of patients' anatomical structures and catheter locations. This technology integrates data from CT, MRI, and real-time mapping systems to create a controllable 3D holographic interface. The platform aims to enhance the delivery of care by allowing clinicians to visualize complex cardiac anatomy directly over the patient, thereby improving the treatment of cardiac arrhythmias during catheterization procedures. SentiAR is in the process of preparing its platform for submission to the FDA.

Impetus Agriculture focuses on developing multiple topical or transgenic insect control products. Products that are safe, effective, and sustainable. Products that are not subject to the same insect resistance that has developed in current commercial products.

Sequoia Sciences is a pharmaceutical company discovering and developing new medicines for the treatment of bacterial infections and cancers. Their development programs consist of small molecules targeting bacterial infections and cancers, and also vaccines for the treatment and prevention of recurrent urinary tract infections. Their goal is to improve the quality of life for those individuals significantly affected by recurrent and chronic bacterial infections and cancers. Sequoia is engaged in research and development programs and collaborations with laboratories, universities, clinical research sites, and private businesses. They have applied their microscale structure determination expertise to elucidate structures of natural products, biosynthetic intermediates, and unexpected synthetic products for academic and industrial collaborators.

Amplified Sciences LLC is a molecular diagnostics company focused on the early detection of debilitating diseases, particularly pancreatic cancer and kidney disease. Utilizing an ultra-sensitive molecular sensing technology licensed from Purdue University, the company’s platform can detect disease markers at the single molecule level, enabling accurate diagnosis from bodily fluids such as urine and saliva. This versatile technology is designed for scalability to point-of-care applications, allowing for effective disease screening with a favorable cost structure. Amplified Sciences has developed a working prototype and has published proof of concept data, positioning itself to meet significant unmet medical needs in diagnostics. Founded in 2016 and based in West Lafayette, Indiana, the company was previously known as Nutrabiotix.

CoverCress Inc. is a biotechnology company based in St. Louis, Missouri, focused on developing and commercializing field pennycress as an oilseed crop. Founded in 2013, the company aims to produce oil for industrial and renewable fuels, as well as meal for nutritious livestock feed. CoverCress specializes in crop breeding services that enhance soil cover during corn harvest and soybean planting, allowing farmers to maximize yields through sustainable agricultural practices. The company is dedicated to utilizing low-input methods to create a feedstock for low carbon intensity biofuels, contributing to more efficient and environmentally friendly agricultural solutions.

FinLocker, LLC is a financial technology company founded in 2014 and based in St. Louis, Missouri. It develops a consumer-enabled financial data platform that facilitates the loan process for mortgages and other financial products. The platform serves both businesses and consumers by streamlining loan transactions and enhancing the overall financial experience. For businesses, FinLocker provides tools that cut costs, reduce fraud, and mitigate risks while improving customer satisfaction and operational efficiency. For consumers, the platform simplifies the loan application process, minimizes paperwork, and enables better management of personal finances. Using consumer consent, FinLocker captures essential borrower data and employs intelligent analytics to offer tailored loan product recommendations based on individual financial profiles.

Ryvit develops an integration software that delivers seamless flow of data between premise and software used in the construction industry. The software integrates software application to enterprise resource product, customer relationship management, e-commerce, social apps, and specialty industry-specific system without exhausting development resources, empowering companies to experience the ease of intelligent integrations, driving profit through automation and optimization of the applications in use. Ryvit is headquartered in Saint Louis, Missouri.

IDEATE Medical develops sterilization technology for the safe and rapid terminal sterilization of all endoscopic devices. The mission of IDEATE Medical is to lower the infection risk from the 75 million endoscope procedures conducted in the U.S. each year. IDEATE Medical understands the importance of efficacy, compatibility, and throughput and has developed a unique, innovative, low-temperature sterilization technology for the safe and rapid terminal sterilization of all endoscopic devices for every procedure. Our technology utilizes the benefits of Vapor Hydrogen Peroxide (VHP) sterilization technology but incorporates key innovations to address the specific challenges associated with the terminal sterilization of long multi-channel endoscopic medical devices. With its innovations, the most challenging endoscopic devices can be terminally sterilized in 30 minutes with no impact on the endoscopic device.

Balance the Superfood Shot is a health supplement company based in Kansas City that specializes in nutritional food supplements aimed at promoting the daily intake of fruits and vegetables. Founded in 2011, the company offers a product line that includes premium health and nutrition items designed to enhance preventative health. Their flagship product provides consumers with a convenient shelf-stable tonic that delivers half a day's serving of organic fruits and vegetables, along with essential multivitamins and nutrients. This approach supports individuals in achieving a healthier, more balanced lifestyle through easy access to vital nutrients.

Viosera Therapeutics is a predict and block drug resistance in cancer and bacteria. The company discovers synergies between approved drugs and develop combinations of drugs that suppress resistance. Antibiotic resistance makes it necessary to develop better treatments for deadly infections. Viosera Therapeutics was founded in July 2016 and is headquartered in Sunnyvale, California.

CheckTheQ, Inc. is a company based in Saint Louis, Missouri, founded in 2016, that offers a subscription service for tracking and communicating real-time wait times. The company primarily serves airports, stadiums, and various venues, providing them with valuable data to optimize operations and enhance the customer experience. CheckTheQ's platform integrates counting and customer response technologies, enabling facilities to monitor restroom usage and receive immediate feedback from passengers. This approach helps to reduce wait times, improve staffing efficiency, and ultimately boost customer satisfaction. By offering an affordable solution tailored for small, regional, and international airports, CheckTheQ aims to enhance operational effectiveness and contribute positively to the overall traveler experience.

Rozzy Learning Company mission is to bring hands-on STEAM (Science, Technology, Engineering, Art, Math) programs and resources to young learners and teachers to promote curiosity, critical thinking skills, and exploration. They focus on STEAM careers because they are the fastest growing, highest paying jobs in the world. By introducing kids to STEAM early on, you are setting them up for success in and outside of school. Unlike other STEAM companies, they have affordable programs that don‘t require expensive technology or materials. Bonus? Their programs fit into teachers’ busy schedules!

KaloCyte, Inc. is a pre-clinical stage healthcare biotech company based in Baltimore, Maryland, founded in 2016. The company focuses on developing ErythroMer, a dried and bio-inspired artificial red blood cell intended to address life-threatening blood loss in situations where stored red blood cells are either unavailable or unsuitable for use. ErythroMer aims to provide context-dependent oxygen delivery while minimizing complications such as vasoconstriction and methemoglobin formation. This innovative approach seeks to enhance trauma care services by offering an effective alternative for managing traumatic hemorrhage when traditional blood supplies are inadequate.

Lean Media, Inc. specializes in cookieless digital advertising services tailored for agribusiness and rural community advertisers. Founded in 2014 and headquartered in Chesterfield, Missouri, the company utilizes a sophisticated audience targeting platform that leverages geo-targeting technology alongside consumer psychographic, demographic, and behavioral insights. By comparing IP addresses with consumer databases, Lean Media enables advertisers to engage individuals at the consumer level, as well as target specific business categories or locations. Their innovative approach aims to enhance engagement and minimize waste in advertising campaigns, providing a reliable solution for reaching target audiences effectively.

Transactly is a real estate technology platform that organizes and coordinates the process of closing a real estate transaction. It is the first tech-enabled transaction coordinator service, and it is nationwide. When hiring them, customers will have their own dedicated and highly reviewed coordinator, along with an entire company supporting them and their business. It was founded in 2018 and is headquartered in St. Charles, Missouri.

Swipesum, Inc. is a payment processing consulting company based in Saint Louis, Missouri, founded in 2016. The company operates a platform that connects businesses with a global network of payment providers and methods, aiming to reduce credit and debit card processing fees, which represent a significant operating expense for U.S. businesses. Swipesum's proprietary technology simplifies the complex landscape of payment solutions, enabling businesses to identify the most suitable options for their needs. The platform allows merchants to initiate an auction where credit card processors compete for their business, ensuring cost-effective processing systems. Additionally, Swipesum offers consulting services that leverage its AI-powered software, Staitment, to streamline the analysis of processing statements for financial institutions and vendors. By providing these services at no upfront cost to businesses, Swipesum generates revenue through recurring finders fees from payment companies they refer, ensuring transparency in their operations. In 2019, Swipesum advised on over $8 billion in processing volume, showcasing its impact in optimizing payment solutions for its clients.

CoverCress Inc. is a biotechnology company based in St. Louis, Missouri, focused on developing and commercializing field pennycress as an oilseed crop. Founded in 2013, the company aims to produce oil for industrial and renewable fuels, as well as meal for nutritious livestock feed. CoverCress specializes in crop breeding services that enhance soil cover during corn harvest and soybean planting, allowing farmers to maximize yields through sustainable agricultural practices. The company is dedicated to utilizing low-input methods to create a feedstock for low carbon intensity biofuels, contributing to more efficient and environmentally friendly agricultural solutions.

Kogent Surgical, LLC specializes in the design, manufacture, and marketing of surgical and neurosurgical instruments. Founded in 2011 and based in Chesterfield, Missouri, the company offers a range of products including curettes, elevators, ball tip probes, forceps, knives, and suction tubes, among others. Kogent Surgical is recognized as an industry leader in neurosurgical instruments, providing high-quality products suited for electrosurgery and microsurgery. The instruments are crafted from lightweight, non-magnetic titanium, allowing for both disposable and reusable options during surgical procedures. In addition to its product offerings, the company also provides surgical instrument repair and restoration services. Kogent Surgical distributes its products worldwide and aims to deliver superior service and cost-effective solutions to its customers.

NexMatix is a developer and manufacturer focused on enhancing the efficiency of pneumatic systems through innovative products. The company specializes in smart valves, particularly directional control valves, which are recognized as some of the most inefficient components in the industry. These valves are equipped with embedded sensors that continuously monitor for leaks, enabling users to identify faults related to pressure and functionality. By improving the performance of these systems, NexMatix aims to reduce operational costs and lower carbon footprints, contributing to more sustainable industrial practices.

Cardiaform is a medical device company developing devices to diagnose and treat cardiovascular disease. Its devices will enable instantaneous high density, high definition electrical maps to support mapping unstable arrhythmias (ventricular tachycardia), reduce procedure time from 3-4 hours to less than 1 hour, and provide improved procedural success using only a single catheter.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

Greetabl is an online gift platform that specializes in creating unique and personalized gifts. It allows users to easily transform their photos into greeting cards that also function as gift boxes. Customers can enhance their gifts by selecting from a variety of options, including gift cards and chocolates, with prices starting at $20. The platform is designed to enable individuals to send thoughtful presents to their friends and loved ones, making gifting simple and accessible.

FocalCast offers a range of interactive web-based market research platforms for global brands and marketing agencies. FocalCast was founded by Devin Turner and Charlie Beckwith in September 2013 and is based in St Louis, Missouri.

Radialogica is a healthcare information technology company that provides software solutions for radiation oncology and the healthcare market. It offers fullAccess, an integrated radiotherapy data display, communication, and analysis platform that enables clinicians across the continuum of care to access, analyze, and share radiotherapy treatment plans, diagnostic images, and other patient data. The company’s platform consists of various licensing modules, including fullView, a vendor-independent RT visualization environment that allows clinicians to view images and treatment plans across various radiotherapy treatment modalities, delivery devices, and planning systems; fullReport tools to analyze and benchmark treatment plans, and automatically extract user-defined dosimetric parameters for retrospective analysis; and fullExchange tools to annotate, package, and share diagnostic images and treatment plans with clinicians and other vested stakeholders inside and outside the clinic. It serves physicians, physicists, dosimetrists, payers, and patients in the United States. The company was incorporated in 2011 and is based in Clayton, Missouri.

SmashToast, Inc. is a technology company founded in 2014 and based in Rochester, Illinois, with a customer service center in Austin, Texas. The company specializes in developing innovative hardware and software solutions that facilitate home automation. Its flagship product is a Bluetooth-enabled device that allows users to control various home electronics, such as televisions, sound bars, air conditioners, and space heaters, through a mobile application. This device eliminates the need for multiple remote controls and cumbersome wires, providing a seamless user experience without line-of-sight constraints. By connecting homes to smartphones, SmashToast empowers customers to monitor and manage their household activities more efficiently.

Galera Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Malvern, Pennsylvania, dedicated to developing innovative therapies that aim to enhance the effectiveness of radiotherapy in cancer treatment. The company’s lead product candidate, avasopasem manganese (GC4419), is a small molecule dismutase mimetic currently undergoing Phase III clinical trials for the treatment of severe oral mucositis induced by radiation in patients with head and neck cancer. Additionally, it is being tested in Phase IIa trials for radiotherapy-induced esophagitis in lung cancer patients. Galera is also advancing a second candidate, GC4711, which is in Phase I/II trials targeting pancreatic and lung cancers. The company was founded in 2012 and is committed to addressing severe side effects associated with cancer treatments to improve patient outcomes.

Dexer is a heads-up, customized speech application and service that streamlines data collection and accessibility across industries.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

CLS is a drug discovery company focusing on rational drug design to discover and develop mechanistically novel kinase inhibitors for use in both human and animal health care. CLS’s kinase inhibitors target key signal transduction enzymes involved in the regulation of cancer growth and survival, or in the modulation of chronic inflammation. Unlike many other kinase inhibitor programs, however, CLS is targeting novel binding sites (on kinase targets that have proved challenging) as well as previously “un-drugged” kinases. Driving CLS success in this effort is a team of world-class experts with extensive Pharma experience in kinase inhibitor discovery and development. CLS provides this team with the opportunity to pursue strategies and targets outside Pharma’s traditional focus. In addition, scientific and business collaborations are being established to enable the success of the business. The strategy is to develop and maintain a program pipeline: discover, develop, partner, repeat.

CoverCress Inc. is a biotechnology company based in St. Louis, Missouri, focused on developing and commercializing field pennycress as an oilseed crop. Founded in 2013, the company aims to produce oil for industrial and renewable fuels, as well as meal for nutritious livestock feed. CoverCress specializes in crop breeding services that enhance soil cover during corn harvest and soybean planting, allowing farmers to maximize yields through sustainable agricultural practices. The company is dedicated to utilizing low-input methods to create a feedstock for low carbon intensity biofuels, contributing to more efficient and environmentally friendly agricultural solutions.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

GeneriCo, LLC is a pharmaceutical company that specializes in the development and marketing of generic drugs. Founded in 2013 and headquartered in Saint Louis, Missouri, with additional offices in Bengaluru, Italy, and South Korea, GeneriCo focuses on niche generic pharmaceuticals that are often overlooked by larger competitors. The company targets foundational medicines in key therapeutic areas, including cardiovascular health, pain management, central nervous system disorders, oncology, and aging-related conditions. GeneriCo distinguishes itself through its expertise in complex formulations and embedded drug delivery technologies, addressing market needs that are typically neglected by mid-sized and large generic firms. The company's global reach enables it to serve a diverse customer base.

Benson Hill is a crop improvement company that unlocks the natural diversity of plants and empowers innovators with a revolutionary crop design platform to develop healthier and more sustainable food and ingredients. Benson Hill empowers innovators to develop more healthy, flavorful, and sustainable food by unlocking the natural genetic diversity of plants. Benson Hill’s CropOS™ platform combines machine learning and big data with breeding techniques and plant biology to drastically accelerate and simplify the product development process.

RNAgri is a company based in St. Louis, Missouri, that specializes in innovative technology for producing ribonucleic acid (RNA). Founded in 2011, the company focuses on addressing the challenges associated with the large-scale production of exogenous RNA interference (RNAi) products. By utilizing a large-scale fermentation process, RNAgri enables farmers to enhance the protection and growth of their crops and livestock through the cost-efficient production of RNA. This technology aims to improve agricultural practices and contribute to more sustainable farming solutions.

CardiaLen, Inc. is a medical device company based in Minneapolis, Minnesota, specializing in the development of innovative therapies for atrial fibrillation and other heart arrhythmias. Founded in 2008, the company is focused on creating implantable, low-energy cardioverter devices that offer pain-free cardioversion therapies. These devices monitor the heartbeat and employ a proprietary series of low-energy pulses to restore normal heart rhythm while minimizing discomfort and preventing damage to heart tissue. By addressing significant unmet needs in the treatment of atrial fibrillation, CardiaLen aims to enhance patient outcomes and reduce reliance on high-energy defibrillation shocks.

RNAgri is a company based in St. Louis, Missouri, that specializes in innovative technology for producing ribonucleic acid (RNA). Founded in 2011, the company focuses on addressing the challenges associated with the large-scale production of exogenous RNA interference (RNAi) products. By utilizing a large-scale fermentation process, RNAgri enables farmers to enhance the protection and growth of their crops and livestock through the cost-efficient production of RNA. This technology aims to improve agricultural practices and contribute to more sustainable farming solutions.

ImmunoPhotonics, Inc. is a biotechnology company focused on developing innovative immunotherapy treatments for cancer, specifically targeting metastatic solid tumors. Founded in 2008 and located in Columbia, Missouri, the company has created a proprietary drug product designed to function as a minimally invasive therapeutic cancer vaccine. This product is administered through intratumoral injection following tumor ablation, leveraging tumor-associated neoantigens to stimulate a systemic anti-tumor immune response. By transforming the process of tumor ablation into a therapeutic approach, ImmunoPhotonics aims to enhance treatment options for patients with late-stage metastatic cancers. The company has also established a strategic partnership with Veterinary Cancer Therapeutics, LLC to further its mission in cancer treatment.

Elira, Inc. is a neurostimulation company based in St. Louis, Missouri, founded in 2015. The company specializes in developing a drug-free wearable device aimed at helping overweight adults manage their weight by suppressing appetite. This innovative device offers a non-invasive method to modulate the central nervous system, providing users with a means to gain control over their eating habits. By effectively reducing appetite, Elira's technology supports individuals in achieving their health and lifestyle goals.

Epharmix is a digital healthcare company that creates clinically validated and condition-specific communication tools. It helps care teams automatically monitor underserved patients to improve care & reduce workload with interventions proven to impact engagement and outcomes. It was founded in 2015 and headquartered in St Louis, Missouri.

Coolfire builds collaboration software for teams on the move. Coolfire’s patented technology connects people, processes, and information in a purpose-built digital workspace. Coolfire’s vision is to keep teams organized around the work at hand and provide them with the critical information they need to keep moving forward. Coolfire is a trusted technology resource for corporate and government customers from Enterprise Rent-A-Car to the US Department of Defense. For more information, visit https://www.coolfiresolutions.com.

CellARide is a technology company specializing in automotive marketing and safety recall communications. It has developed a platform that enables users to create mobile brochures for their vehicles, facilitating direct communication with potential customers. By leveraging widely used mobile messaging technologies, CellARide provides automotive marketers, manufacturers, and advocacy organizations with consumer insights, compliant communication tools, and a data capture platform. This approach allows clients to engage effectively with consumers and obtain real-time, actionable data, enhancing their marketing efforts. Through its innovative solutions, CellARide aims to streamline the marketing process for automotive brands and dealerships, making it easier to connect with shoppers.

Cancer cells spread through the circulatory system as “circulating tumor cells” (CTCs) and represent unique diagnostic targets. CTCs are released from primary tumors into blood circulation and then lodge at distant organs to initiate new cancer growth. Thus circulating tumor cells constitute the major cause for mortality among cancer patients. Recent advancements in detection and characterization of CTCs can have a significant impact on early cancer detection. For instance, the quantization of CTCs can be used for prognosis of the outcomes of metastatic diseases. In another example, identification of cancer stem cells, a subpopulation of CTCs believed to be tumorigenic, can be used for identifying metastasis and recurrence of disease.

Time To Cater is a web-based platform that helps companies and individuals coordinate their ideal catered even at NO EXTRA COST to client. If you have had to coordinate catering for events or if you need food ordered quickly online, and especially if you have done it consistently, you understand that valuable time is wasted calling potential caterers for availability, prices, and delivery details, etc. We fix this problem by providing a web-based platform and mobile app that helps companies and individuals coordinate their ideal catered event. Our client only has to submit their event details and budget to our web application and then show up for the event and enjoy! We take care of EVERYTHING in between. And the BEST part is that there is NO EXTRA COST to our client for our service! We make money by making a commission from the caterers in our Preferred Caterer Network.

TrackBill is a provider of legislative tracking and reporting software that helps users stay informed about significant legislative actions, including bill introductions, amendments, hearings, and votes. The platform offers real-time alerts, enabling users to respond promptly to changes in legislation. TrackBill simplifies the process of legislative reporting by allowing clients to generate professional documents in various formats such as Word, PDF, and Excel. Additionally, it offers customizable and auto-updating website feeds, enhancing the accessibility of legislative information. This focus on workflow automation supports public affairs teams in managing their activities efficiently while ensuring stakeholders remain informed.

Founded in April of 2008 and based in St. Louis, MO, aisle411 is a trusted indoor location services platform for major global leading retailers. For shoppers, aisle411 makes shopping in-stores easier, allowing them to map products, offers and lists by aisle location, as well as discover unique information based on a shopper’s in-store location. For retailers, aisle411 offers a mobile in-store location services platform that allows them to reach shoppers at the shelf, with context and location relevant information that enhances the shopper experience. aisle411’s proprietary, first-of-its-kind indoor retail mapping and location service and mobile platform allows shoppers to easily navigate through retail stores to find exactly what they want quickly by collecting, organizing and monetizing retailers’ product inventory, location data, and enterprise software space planning systems and store maps. aisle411 has also partnered with leading indoor positioning technology providers to provide shopper positioning services that drive merchandising insights and allow for engaging shopper experiences. The service ultimately drives higher customer satisfaction and a deeper level of engagement between the retailers and its customers by —simplifying the shopping experience.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

BacterioScan is a precision bench-top system that enables rapid detection and real-time quantification of microbial growth. It eliminates workflow bottlenecks and the inherent inaccuracies of legacy plating procedures. Its technology is helping clinicians personalize medicine for patients, and it’s helping researchers bring new antibiotics to market faster and more economically. The potential applications are far-ranging, offering considerable advantages for any microbiology laboratory that can benefit from rapid detection and real-time quantification of bacterial growth, as well as BacterioScan’s space-saving bench-top footprint and its rapid return on investment.

Adarza BioSystems is an early-stage medical diagnostics company based in St. Louis, Missouri, founded in 2008. The company specializes in developing a rapid and label-free biological assay platform that measures clinical and point-of-care samples. This innovative platform employs diagnostic arrayed imaging reflectometry (AIR) to enable the simultaneous detection of hundreds of analytes from a single drop of fluid, allowing healthcare professionals to conduct sophisticated tests with high sensitivity and specificity. By significantly reducing the time required for testing, Adarza BioSystems aims to enhance diagnostic capabilities in various healthcare settings.

Elemental Enzymes Inc. is a manufacturer of specialized enzymes designed for optimal performance in challenging environments, both in agriculture and industrial applications. The company produces a diverse range of enzymes, including those that degrade cellulose and starches for fuel production, and stable enzymes that provide eco-friendly alternatives to harsh chemicals used in processes like fracking. Additionally, Elemental Enzymes develops solutions for capturing and storing carbon dioxide and for breaking down proteins and antibiotics to prevent contamination of water supplies. The company also offers customized enzyme solutions tailored to address specific environmental contaminants, as well as enzymes for various non-environmental applications. Founded in 2011 and based in Columbia, Missouri, Elemental Enzymes was previously known as Spogen Biotech, Inc. and leverages patented technologies and scientific advancements to meet the evolving needs of its customers.

Acera Surgical, Inc. specializes in developing fully synthetic surgical materials that serve as resorbable scaffolds for soft tissue repair and regeneration. The company's innovative products include hybrid-scale fiber matrices designed to mimic the structure of human tissue, providing flexibility and strength while resisting enzymatic degradation. These materials enhance surgical efficiency, minimize complications and costs, and promote superior clinical outcomes. By offering an alternative to traditional biologics, Acera's solutions empower healthcare professionals to improve patient healing effectively.

Akermin is based in St. Louis, Missouri, and was formed in 2004 to commercialize breakthrough stabilized enzyme technology invented at Saint Louis University. In 2008, Akermin demonstrated its prototype of a fully functioning biofuel cell operating on methanol fuel and using stabilized laccase to replace the metal catalyst in conventional cathodes. Commercial applications in wireless sensors and military uses are their primary focus. Development for the use of stabilized enzymes in the food processing, biofuels, chemical, and pharmaceutical industries is under way.

Tunespeak, LLC operates a musician-to-fan loyalty platform that rewards users for engaging with music and related content. Founded in 2011 and based in St. Louis, Missouri, the platform allows users to earn points by listening to music, watching videos, viewing photos, and sharing content with friends. Users can accumulate points not only for their own activity but also for enabling their friends to participate in contests or raffles for every song, picture, and video shared. Through this unique engagement model, Tunespeak aims to enhance the connection between musicians and their fans while offering incentives such as tickets, experiences, and merchandise.

BenchmarkONE develops sales and marketing automation software tailored for small and mid-sized businesses. The company offers an integrated platform that includes customer relationship management (CRM) tools and sales automation features, allowing users to monitor contacts' activities, track deals, manage communications, and segment their audience. Additionally, BenchmarkONE provides email marketing capabilities with a user-friendly drag-and-drop email builder and marketing automation tools designed to engage visitors, prioritize leads, and optimize campaign investments. Originally known as Hatchbuck, Inc., the company rebranded to BenchmarkONE in June 2020 and has been operational since 2010, with its headquarters in St. Louis, Missouri. As of September 2019, BenchmarkONE functions as a subsidiary of Benchmark Internet Group, LLC.

NeuroLutions Inc. is a company based in St. Louis, Missouri, focused on developing brain-computer interface (BCI) devices aimed at restoring functions for patients disabled due to neurological injuries, particularly stroke survivors. Founded in 2007, NeuroLutions employs non-invasive electroencephalography (EEG) technology to capture brain activity without the need for implanted electrodes. The EEG data is wirelessly transmitted to a tablet, where it is analyzed to interpret the patient's intended muscle movements. This innovative approach enables users to facilitate muscle re-education and helps maintain or improve their range of motion, thereby enhancing rehabilitation outcomes for individuals with movement impairments.

CardiaLen, Inc. is a medical device company based in Minneapolis, Minnesota, specializing in the development of innovative therapies for atrial fibrillation and other heart arrhythmias. Founded in 2008, the company is focused on creating implantable, low-energy cardioverter devices that offer pain-free cardioversion therapies. These devices monitor the heartbeat and employ a proprietary series of low-energy pulses to restore normal heart rhythm while minimizing discomfort and preventing damage to heart tissue. By addressing significant unmet needs in the treatment of atrial fibrillation, CardiaLen aims to enhance patient outcomes and reduce reliance on high-energy defibrillation shocks.

Kypha Inc. is a life sciences company focused on developing and commercializing in-vitro diagnostic biomarker tests for inflammation and autoimmune disorders. Based in St. Louis, Missouri, the company offers the COMP ACT System, which enhances the monitoring and treatment of various health conditions, including lupus, stroke, traumatic brain injury, preeclampsia, infection, kidney disease, and transplant rejection. Kypha aims to provide rapid and accurate assessments of inflammation levels, enabling healthcare professionals to make timely and informed clinical decisions. With a core team supported by scientific advisors and clinical collaborators, Kypha has successfully secured federal grants and raised private capital to advance its diagnostic products toward regulatory approval and market launch. The company's technology is designed for scalability, facilitating testing in diverse settings from home health to clinical laboratories, ultimately improving patient outcomes through timely intervention.

Decide is powering the future of performance-based advertising on the open web. Through custom ad formats, flexible integration types, and our homegrown machine-learning platform, the Decision Marketplace, Decide optimizes returns for advertisers and maximizes yield for publishers. Our proprietary attribution and targeting technologies enable industry-leading measurement and eliminate the need for third-party cookies or other intrusive data.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

Bonfyre Inc. is an employee engagement platform founded in 2013 and based in Saint Louis, Missouri. The company focuses on transforming workplace culture by providing technology that enhances employee recognition, communication, feedback, and event management. Its mobile-first platform offers real-time communication tools such as announcements, targeted broadcasts, and pop surveys, which help organizations foster camaraderie, align their culture, and gather valuable HR insights. By modernizing employee communications, Bonfyre enables companies to build stronger relationships and increase engagement, ultimately promoting a collaborative and innovative work environment.

Traxxsson is a biotechnology company that develops diagnostics for cancer using protein biomarkers. It uses a proprietary panel of biomarkers to identify at-risk patients who have questionable radiology images. It has three tests: PRO CancSure to identify prostate cancer patients in need of aggressive treatment, BRE CancSure to confirm the presence of breast cancer in women with positive mammograms, and LNG CancSure to confirm the presence of lung cancer in patients with positive low-density CAT scan results. The company was founded in 2009 and is based in St. Louis, Missouri.

Nawgan offers a brain-friendly functional beverage developed to provide both long and short-term benefits for the brain. Nawgan contains citicoline (a combination of choline and cytidine); Alpha-GPC (Alpha-glyceryl phosphorylcholine – claimed to increase acetylcholine in the brain); lycopene; caffeine (100mg); and natural vitamin E. Unlike many products in the cognitive function market, claims made by Nawgan were supported by research on the end product rather than extrapolations based on literature about individual ingredients.

Euphrates Vascular is a medical technology company based in St. Louis, Missouri, focused on developing innovative solutions for the treatment of stroke, heart disease, and other related conditions. The company's flagship product, the magnetically-enhanced diffusion (MED) system, employs advanced magnet-based technology to accelerate the dissolution of blood clots, offering a faster delivery of FDA-approved clot-busting medications compared to traditional methods. This technology aims to significantly reduce mortality rates associated with strokes and heart disease. In addition to the MED system, Euphrates Vascular offers MED MicroBeads, which facilitate the rapid delivery of selected therapeutic agents to blood clots, and a touch screen-operated MED Workstation for enhanced user interaction. Founded by physicists with extensive experience in medical technology, the company continues to attract interest from investors and media for its groundbreaking contributions to cardiovascular care.

Katalyst Surgical, LLC provides titanium ophthalmic surgical instruments. It offers cannulas, forceps, hooks/manipulators, lasik products, needle holders, phaco choppers, scissors, speculum, and related products online. Katalyst Surgical, LLC was incorporated in 2010 and is based in Chesterfield, Missouri.

Somark Innovations specializes in advanced identification solutions for laboratory animals, focusing on enhancing the integrity of the chain of custody. The company has developed chip-less radio frequency identification tattoos that offer accurate and consistent identification, promoting both animal welfare and data integrity. By improving the identification process, Somark aims to facilitate better scientific outcomes for researchers and support companies engaged in research advancements. In addition to its primary focus on lab animal identification, Somark also provides inventory management identification systems for various applications, including automotive parts, documents, and casino chips.

Akermin is based in St. Louis, Missouri, and was formed in 2004 to commercialize breakthrough stabilized enzyme technology invented at Saint Louis University. In 2008, Akermin demonstrated its prototype of a fully functioning biofuel cell operating on methanol fuel and using stabilized laccase to replace the metal catalyst in conventional cathodes. Commercial applications in wireless sensors and military uses are their primary focus. Development for the use of stabilized enzymes in the food processing, biofuels, chemical, and pharmaceutical industries is under way.

Appistry Inc. specializes in developing bioinformatics tools, cloud services, and software solutions to facilitate genomically enhanced medicine for healthcare institutions. The company provides a range of products, including Appistry CloudDx, which supports patient-centered translational research and the integration of genome-scale tests into routine patient care. Their offerings also include CloudDx Translational, a solution for centralizing data and communication across various research projects, as well as tools for analyzing whole genomes, exomes, and tumor-normal pair data. Additionally, Appistry's GenomePilot and Genome Analysis Toolkit help bioinformaticians and researchers navigate complex next-generation sequencing (NGS) analysis processes and derive actionable insights from NGS datasets. The Cancer Genome Analysis Suite and Variant Annotation and Analysis Suite further enhance the company's capabilities by providing integrated tools for addressing challenges in cancer genomics and variant analysis. Founded in 2001 and based in St. Louis, Missouri, Appistry was previously known as Tsunami Research, Inc. before rebranding in 2005.