Elevate Capital is a venture capital firm based in Hillsboro, Oregon, established in 2016. It focuses on seed and early-stage investments across the United States, with a regional emphasis on the Pacific Northwest and Portland metro area. The firm targets technology-enabled startups and seeks to diversify founder representation, supporting ventures founded by underrepresented entrepreneurs. Elevate Capital typically participates in early rounds and makes minority investments, providing more than capital through advisory support and access to networks to aid long-term growth. Portfolio scope includes software, life sciences, hardware, consumer products, fintech, healthcare, sustainability, and related technology sectors.

High Alpha, headquartered in Indianapolis, Indiana, operates as a B2B SaaS venture studio and early-stage investor. It conceives, launches, and scales B2B SaaS companies through High Alpha Studio, offering a blend of services including design, finance, talent, marketing, branding, and go-to-market support, alongside capital to accelerate growth toward enterprise-scale outcomes.

Founded in 2010, Allos Ventures is a venture capital firm based in Carmel, Indiana. The firm invests in early-stage B2B software and business services companies across the Midwest, focusing on accelerating growth and building value for these businesses.

IU Ventures, established in Bloomington, Indiana since 1997, supports Indiana University students, faculty, staff, and alumni in exploring new venture opportunities. It focuses on investments in B2B, healthcare, and technology sectors.

VisionTech Angels, founded in 2009 and based in Indianapolis, Indiana, is an angel investment group that focuses on early-stage technology companies with innovative products and services. The firm targets high-potential businesses operating in various sectors, including life sciences, software as a service (SaaS), Internet of Things (IoT), advanced materials, supply chain, and hardware. VisionTech Angels seeks to invest between $200,000 and $1 million in companies with a pre-money valuation under $10 million. The ideal candidates are those within 12 months of reaching breakeven or that have identified their next round of financing, demonstrating progress towards key milestones. The firm aims for exits within a timeframe of three to seven years, emphasizing investments in firms with strong management teams and clear competitive advantages in large markets.

Collina Ventures is a venture capital firm based in Carmel, Indiana, United States, that makes minority investments across seed, early, and later stages in software and technology companies with a focus on Central Indiana.

Founded in 2011, Hyde Park Venture Partners is a Chicago-based venture capital firm specializing in early-stage investments. It focuses on high-growth technology startups across the Midwest, with an emphasis on software and tech-enabled businesses. The firm typically invests between $0.1 million to $2.5 million, co-investing with Hyde Park Angels. They actively mentor portfolio companies, supporting product development, business strategy, financing, and exit strategies.

Flywheel Fund is a venture capital firm based in Bloomington, Indiana. Founded in 2020, it invests in Indiana-based early-stage technology startups, with a focus on life sciences, medical devices, and software-enabled technologies.

Heron Capital is a venture capital investment firm based in Indianapolis, Indiana, founded in 2005. The firm focuses on providing growth and late-stage funding to companies in the life sciences and healthcare sectors, including therapeutic devices, diagnostics, healthcare services, manufacturing, and related areas, with activity extending across the United States and Canada. It targets mid- and growth-stage companies and seeks investments in ventures with strong intellectual property and high-quality management. The firm is advised by a network of scientists, physicians, entrepreneurs, and leaders of national and multinational corporations to support portfolio companies.

4G Ventures is a venture capital firm located in Indianapolis, Indiana. The firm specializes in a variety of sectors, including real estate, restaurants, event venues, and hotels. It focuses on providing vacation rentals, community projects, and development services, aiming to create a diverse portfolio of businesses and investments. Through its multifaceted approach, 4G Ventures seeks to foster growth and innovation across its various ventures.

Charmides Capital is a venture capital firm based in Carmel, Indiana, that co-invests with institutional investors to fund early-stage startups in Indiana and the broader Midwest. The firm focuses on B2B software as a service companies with high growth potential, backing ventures in their formative development stages. It leverages a team of partners with diverse backgrounds to provide strategic value and operational support to portfolio companies. The Midwest focus aims to nurture local founders and cultivate scalable businesses through selective investments and collaborative partnerships with institutional investors.

BidPal has rebranded as OneCause. Raise more money and reach more donors with OneCause Fundraising Software and BidPal Mobile Bidding. Located in the technology hub of Indianapolis, OneCause has been recognized on the Inc. 500 list of Fastest Growing Companies and has received a Techpoint MIRA award for Mobile Technology Excellence & Innovation. The company’s fundraising technology includes: Mobile Bidding, Online Fundraising, Peer to Peer Fundraising, Event Software, Payment Processing, Online Ticketing, Mobile Donations, Text2Give, and Registration and Checkout software.

Gravity Ventures is a venture capital firm based in Indianapolis, Indiana, founded in 2008. It specializes in investing in early-stage technology and tech-enabled companies across various industries, providing seed and early-stage capital to startups with a focus on software and related tech sectors.

Health Cloud Capital is a growth and expansion investment firm based in Indianapolis that concentrates on healthcare information technology and digital health companies. It targets cloud-enabled software-as-a-service businesses that are experiencing scale and disruption in healthcare delivery, including data-driven approaches to value-based care. The company emphasizes healthcare IT, diagnostics, and cloud analytics, and seeks SaaS providers with proven recurring revenue and the potential to improve outcomes through data science. The team brings substantial investing and operating experience in healthcare, IT, and diagnostics, and collaborates closely with portfolio companies to support growth. Founded in 2017, Health Cloud Capital positions itself at the intersection of cloud technology and healthcare, aiming to accelerate the adoption of digital health solutions and value-based care.

HG Ventures is the venture capital arm of The Heritage Group, headquartered in Indianapolis, Indiana. It funds and partners with early-stage and growth-stage companies developing advanced materials and systems for transportation, infrastructure, environmental services, and specialty chemicals, including digital solutions relevant to these industries. The firm emphasizes United States opportunities and leverages The Heritage Group's operating companies and research center to provide portfolio companies with industry expertise, commercial networks, and technical capabilities. HG Ventures pursues a value-add approach by supporting companies through strategic collaboration and scaling their technologies, often investing in collaborations that align with the Heritage Group's core businesses.

Founded in 2019, Boomerang Ventures is a venture capital firm based in Indianapolis, Indiana. It focuses on building commercially successful companies in the future of healthcare, with an emphasis on connected medical devices, digital health, tech-enabled health services, and healthcare informatics.

Spring Mill Venture Partners is a venture capital firm based in Carmel, Indiana, established in 2004. The firm specializes in seed and early-stage investments, primarily targeting high-growth companies within the information technology, healthcare technology, and life sciences sectors. Its investment focus is on businesses located in Indiana and the surrounding Midwest region, which includes Illinois, Kentucky, Michigan, and Ohio. Spring Mill Venture Partners aims to provide both capital and strategic support to help early-stage companies achieve sustainable growth and success.

Founded in 2022, Ground Game Ventures is a venture capital firm based in Indianapolis, Indiana. It focuses on investing in early revenue and seed-stage companies operating within the B2B and SaaS sectors.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin. It specializes in early-stage investments across various sectors including life sciences, information technology, advanced manufacturing, B2B, and healthcare, with a focus on companies located in the Midwest region of the United States.

Founded in 1994, Pappas Capital is a venture capital firm specializing in life sciences. It invests in biotechnology, biopharmaceuticals, medical devices, and related ventures across North America, with a focus on preclinical to Phase 3 companies.

Founded in 2006, New Capital Fund is a venture capital firm based in Little Chute, Wisconsin. It focuses on investing in seed-stage to growth-stage companies across various sectors including business products/services, materials/resources, healthcare, information technology, advanced manufacturing, life sciences, and TMT.

Eli Lilly and Company is a global pharmaceutical leader engaged in the discovery, development, manufacture, and sale of medicines. It operates facilities in the United States, Puerto Rico, and many other countries, with products sold in about 135 countries. The company focuses on therapies in neuroscience, cardiometabolic, cancer, and immunology, and also conducts research in animal health and animal agriculture. Lilly supports patient outcomes and education through a philanthropic foundation that funds programs in underserved communities, including STEM education in Indianapolis.

Lightship Capital is a venture capital firm focused on investing in early-stage startups, particularly those led by underrepresented minorities and located outside of major tech hubs like Silicon Valley, New York City, and Boston. The company concentrates its investments in sectors such as artificial intelligence, consumer packaged goods, sustainability, e-commerce, healthcare, and real estate.

Pearl Street Venture Funds, established in 2003, is a venture capital firm focused on investing in early-stage life sciences companies. It specializes in biotech, pharmaceuticals, medical devices, and agri-bio sectors, with a preference for Indiana-based companies. The firm can act as both lead and co-investor.

Founded in 2024 and based in Indianapolis, Indiana, Roll Tack Ventures is a venture capital firm that collaborates with innovative technology entrepreneurs to address significant challenges. The firm invests in midmarket companies with a focus on those operating within the Midwest region.

Omnidollar Ventures is an industry-agnostic investment syndicate based in Indianapolis, Indiana, founded in 2020. The company specializes in early-stage investments, focusing primarily on the SportsTech and FinTech sectors. It targets pre-seed and seed companies, aiming to support innovative startups in sports, fitness, and wellness technologies. By leveraging its expertise, Omnidollar Ventures seeks to identify and nurture promising ventures that can drive growth and transformation within these industries.

Sixty8 Capital is a seed-stage venture capital firm based in Indianapolis, Indiana, founded in 2019 by Kelli Jones and Paul Ehlinger. The firm specializes in investing in technology, tech-enabled, and direct-to-consumer startups, with a particular emphasis on supporting entrepreneurs from diverse communities, including Black, Brown, women, and LGBTQ+ founders. Sixty8 Capital is backed by Allos Ventures, which brings 45 years of venture capital experience to the firm, enhancing its commitment to fostering innovation and inclusivity in the startup ecosystem.

Founded in 2009, Ludlow Ventures is a Michigan-based venture capital firm specializing in early-stage investments. It focuses on technology companies across the United States, typically investing between $25,000 and $150,000 per company. Known for its straightforward approach, it aims to build trust and friendship with invested teams.

Detroit Venture Partners is a Detroit-based venture capital firm that focuses on seed and early-stage technology investments across the United States, with emphasis on Detroit and Ontario. The firm backs internet, digital media, marketing technology, direct-to-consumer, sports and entertainment, social media, e-commerce, software, B2B software, mobile applications, and related sectors such as Adtech and enterprise software-as-a-service. It typically makes initial investments in the range of USD 0.25 to 0.75 million, with follow-on rounds between 2 and 3 million, and can participate up to about 3 million per investment. Founded in 2010, it aims to support entrepreneurial ventures that help rebuild the Detroit area and foster growth in technology-driven businesses.

Founded in 2013, Annox Capital is a venture capital firm based in Birmingham, Michigan. It invests in companies that employ disruptive technology or online strategies to significantly improve business processes or human experiences across various sectors such as manufacturing, logistics, banking, healthcare, and real estate.

Founded in 2012, IrishAngels is an early-stage venture firm based in Chicago. It focuses on investing in promising pre-seed and seed stage startups across the US, with a primary interest in B2B SaaS, consumer, and medical companies.

Mutual Capital Partners, established in 2004, is a private equity firm headquartered in Westlake, Ohio. The company specializes in venture capital investments, focusing on medical device and healthcare IT companies across the United States. It typically leads or co-leads investments, providing not only capital but also strategic guidance and operational support to its portfolio companies. The firm works closely with its network of over 100 investors, leveraging their expertise for due diligence, customer introductions, and ongoing executive counsel.

Founded in 2012, Cultivation Capital is a venture capital firm based in Saint Louis, Missouri. The firm focuses on early-stage investing in life sciences, health technology, software, IT, agriculture tech, and geospatial tech sectors.

Founded in Boston in 2004, RA Capital is an investment firm specializing in life sciences and drug development. Its team, with backgrounds in biology, chemistry, medicine, and industry experience, invests in early-stage companies with promising technologies and products across healthcare and life science sectors.

Founded in 2012, Chicago Ventures is a venture capital firm based in Chicago, Illinois. It partners closely with exceptional entrepreneurs building companies in undercapitalized high-potential ecosystems, focusing on seed-stage investments in healthcare, business services, and technology-facing companies across the Midwest.

New Enterprise Associates is a venture capital firm founded in 1977 and based in Menlo Park, California, with offices in the United States, India and China. It makes investments across technology and healthcare startups at multiple stages, from seed to growth, including software, cloud, data, internet services, fintech, AI, e-commerce, and enterprise technology, as well as healthcare information technology, life sciences, medical devices, and biopharma. It also considers energy technology and infrastructure opportunities, such as solar, batteries and smart grids. The firm pursues a global approach, with activity in the United States, Asia and other regions, and supports companies through rounds of financing ranging from small to sizable investments as they scale. NEA focuses on building portfolios in software, IT services, consumer technology, and healthcare technology, backing ambitious entrepreneurs across sectors and geographies.

Plymouth Growth is a Michigan-based investment firm focused on growth-stage technology companies, primarily in B2B software and tech-enabled services in the United States and Canada. Based in Ann Arbor, the firm targets mid-continent opportunities and emphasizes partnering with entrepreneurs with proven business models and strong teams. It prioritizes people and culture alongside metrics, leveraging operational and advisory experience to support scalable growth. Plymouth Growth manages multiple growth funds and seeks to help portfolio companies accelerate expansion through strategic guidance and capital.

The LegalTech Fund is a venture capital firm based in the United States that focuses on investing in companies innovating within the legal industry. Established in 2022, it targets a diverse range of sectors, including information technology, financial services, consumer products and services, and business products and services. The firm aims to support the growth of legal technology and related fields by investing up to one million dollars in promising ventures. Its investment strategy encompasses both North America and Europe, reflecting a commitment to fostering advancements that can transform the practice of law. The LegalTech Fund seeks to empower startups and established companies that are reshaping the legal landscape through technological innovation.

Everywhere Ventures is a New York-based venture capital firm focused on early-stage, pre-seed investments. Founded by founders for founders, it operates as a community-powered investing platform that unites capital, expertise, and mentoring from a broad network of founders and operators across ten micro funds. The firm supports global startups in their first financing rounds, with a focus on purpose-driven teams across money, health, and work verticals. Its model combines hands-on guidance from experienced builders with early-stage funding to help entrepreneurs build durable companies.

Founded in 1989, OrbiMed is a New York-based healthcare-dedicated investment firm managing approximately $5 billion in assets. It invests across the spectrum of healthcare companies, from private start-ups to large multinational corporations, focusing on biopharmaceuticals, life sciences, digital health, medical devices, and diagnostics sectors globally.

Founded in 1999, OCA Ventures is a Chicago-based venture capital firm focusing on early-stage investments primarily in technology and highly-scalable services businesses. The firm's investment focus areas include digital health, fintech, consumer software, and enterprise software.

Founded in 1995, SOSV is a global venture capital firm headquartered in New Jersey. It focuses on seed-to-growth stage investments in deep tech innovations, primarily in bio-tech/life sciences and hardware/robotics sectors, with a commitment to human and planetary health.

Revolution is a Washington, D.C.–based venture capital firm founded in 2005 by Steve Case, with an additional office in San Francisco. It backs technology-enabled startups that disrupt traditional industries and supports both early-stage and growth-stage companies, often taking leadership roles in financings and serving on boards. The firm operates a family of funds, including Revolution Ventures and Revolution Growth, and seeks opportunities across sectors such as consumer internet, software and services, media, financial services, healthcare, and other technology-enabled businesses. It emphasizes geography, aiming to back high-potential ventures in regions beyond traditional hubs by pairing capital with hands-on involvement and broad entrepreneurial networks.

Norwest Venture Partners is a global technology venture capital firm founded in 1961 and based in California. It invests across venture and growth stages in the United States, India, Israel, and other markets, targeting software, cloud and IT infrastructure, information services, enterprise software and services, financial services, consumer products and healthcare. The firm backs entrepreneurs with capital plus an extensive network and operating experience to help scale their businesses. Since its inception it has backed hundreds of companies and manages a multi-billion-dollar portfolio, deploying capital in seed to growth rounds and across sectors that drive technology-enabled growth. Norwest emphasizes building lasting relationships with founders and mentoring teams through strategic guidance and market access to accelerate expansion and scale globally.

Connetic Ventures is a venture capital firm based in Covington, Kentucky. Established in the mid-2010s, it provides capital and strategic support to early-stage startups, often partnering with other venture capital firms and angel syndicates for seed investments. The firm targets software, data, fintech, and consumer sectors across North America, including the United States and Canada.

Serra Ventures is a venture capital firm based in Champaign, Illinois, that invests in technology companies across the United States and select international locations. The firm concentrates on early-stage and growth opportunities in information technology, deep technology, instrumentation, software as a service, devices, B2B, and agricultural technologies, with a focus on the Midwest and West Coast regions. Serra Ventures supports portfolio companies through strategic guidance, networks, and resources to help scale technology-enabled businesses.

Breakthrough Energy Ventures is an investor-led venture capital firm based in Kirkland, Washington, focused on climate and energy technology. It makes minority investments across seed, early, and later stages in companies delivering environmental services, climate technology, and cleantech solutions. The firm seeks scalable technologies that provide reliable, affordable power while reducing greenhouse gas emissions and supports innovations that address energy access, infrastructure, and transportation needs. Its mission emphasizes patient, impact-oriented investing to accelerate the transition to low-emission energy systems.

Founded in 1911, Bessemer Venture Partners is a venture capital firm based in Redwood City, California. With over $4 billion under management, the firm invests globally across various sectors including artificial intelligence & machine learning, biotech, cloud, consumer, cybersecurity, deep tech, developer, fintech, healthcare, marketplaces, and vertical software. Known for its long-standing support of entrepreneurs, Bessemer has backed companies such as Pinterest, Shopify, Twilio, Yelp, and Linkedin.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.