St. Louis Arch Angels

SentiAR, Inc. is a digital health company based in St. Louis, Missouri, specializing in 3D augmented reality solutions for interventional medical procedures. Founded in 2017 as a spin-off from Washington University, SentiAR has developed a platform that offers real-time holographic visualization of patients' anatomical structures and catheter locations. This technology integrates data from CT, MRI, and real-time mapping systems to create a controllable 3D holographic interface. The platform aims to enhance the delivery of care by allowing clinicians to visualize complex cardiac anatomy directly over the patient, thereby improving the treatment of cardiac arrhythmias during catheterization procedures. SentiAR is in the process of preparing its platform for submission to the FDA.

CoverCress Inc. is a biotechnology company based in St. Louis, Missouri, focused on developing and commercializing field pennycress as an oilseed crop. Founded in 2013, the company aims to produce oil for industrial and renewable fuels, as well as meal for nutritious livestock feed. CoverCress specializes in crop breeding services that enhance soil cover during corn harvest and soybean planting, allowing farmers to maximize yields through sustainable agricultural practices. The company is dedicated to utilizing low-input methods to create a feedstock for low carbon intensity biofuels, contributing to more efficient and environmentally friendly agricultural solutions.

FinLocker, LLC is a financial technology company founded in 2014 and based in St. Louis, Missouri. It develops a consumer-enabled financial data platform that facilitates the loan process for mortgages and other financial products. The platform serves both businesses and consumers by streamlining loan transactions and enhancing the overall financial experience. For businesses, FinLocker provides tools that cut costs, reduce fraud, and mitigate risks while improving customer satisfaction and operational efficiency. For consumers, the platform simplifies the loan application process, minimizes paperwork, and enables better management of personal finances. Using consumer consent, FinLocker captures essential borrower data and employs intelligent analytics to offer tailored loan product recommendations based on individual financial profiles.

Ryvit develops an integration software that delivers seamless flow of data between premise and software used in the construction industry. The software integrates software application to enterprise resource product, customer relationship management, e-commerce, social apps, and specialty industry-specific system without exhausting development resources, empowering companies to experience the ease of intelligent integrations, driving profit through automation and optimization of the applications in use. Ryvit is headquartered in Saint Louis, Missouri.

CheckTheQ, Inc. is a company based in Saint Louis, Missouri, founded in 2016, that offers a subscription service for tracking and communicating real-time wait times. The company primarily serves airports, stadiums, and various venues, providing them with valuable data to optimize operations and enhance the customer experience. CheckTheQ's platform integrates counting and customer response technologies, enabling facilities to monitor restroom usage and receive immediate feedback from passengers. This approach helps to reduce wait times, improve staffing efficiency, and ultimately boost customer satisfaction. By offering an affordable solution tailored for small, regional, and international airports, CheckTheQ aims to enhance operational effectiveness and contribute positively to the overall traveler experience.

Lean Media, Inc. specializes in cookieless digital advertising services tailored for agribusiness and rural community advertisers. Founded in 2014 and headquartered in Chesterfield, Missouri, the company utilizes a sophisticated audience targeting platform that leverages geo-targeting technology alongside consumer psychographic, demographic, and behavioral insights. By comparing IP addresses with consumer databases, Lean Media enables advertisers to engage individuals at the consumer level, as well as target specific business categories or locations. Their innovative approach aims to enhance engagement and minimize waste in advertising campaigns, providing a reliable solution for reaching target audiences effectively.

Transactly is a real estate technology platform that organizes and coordinates the process of closing a real estate transaction. It is the first tech-enabled transaction coordinator service, and it is nationwide. When hiring them, customers will have their own dedicated and highly reviewed coordinator, along with an entire company supporting them and their business. It was founded in 2018 and is headquartered in St. Charles, Missouri.

Swipesum, Inc. is a payment processing consulting company based in Saint Louis, Missouri, founded in 2016. The company operates a platform that connects businesses with a global network of payment providers and methods, aiming to reduce credit and debit card processing fees, which represent a significant operating expense for U.S. businesses. Swipesum's proprietary technology simplifies the complex landscape of payment solutions, enabling businesses to identify the most suitable options for their needs. The platform allows merchants to initiate an auction where credit card processors compete for their business, ensuring cost-effective processing systems. Additionally, Swipesum offers consulting services that leverage its AI-powered software, Staitment, to streamline the analysis of processing statements for financial institutions and vendors. By providing these services at no upfront cost to businesses, Swipesum generates revenue through recurring finders fees from payment companies they refer, ensuring transparency in their operations. In 2019, Swipesum advised on over $8 billion in processing volume, showcasing its impact in optimizing payment solutions for its clients.

CoverCress Inc. is a biotechnology company based in St. Louis, Missouri, focused on developing and commercializing field pennycress as an oilseed crop. Founded in 2013, the company aims to produce oil for industrial and renewable fuels, as well as meal for nutritious livestock feed. CoverCress specializes in crop breeding services that enhance soil cover during corn harvest and soybean planting, allowing farmers to maximize yields through sustainable agricultural practices. The company is dedicated to utilizing low-input methods to create a feedstock for low carbon intensity biofuels, contributing to more efficient and environmentally friendly agricultural solutions.

Kogent Surgical, LLC specializes in the design, manufacture, and marketing of surgical and neurosurgical instruments. Founded in 2011 and based in Chesterfield, Missouri, the company offers a range of products including curettes, elevators, ball tip probes, forceps, knives, and suction tubes, among others. Kogent Surgical is recognized as an industry leader in neurosurgical instruments, providing high-quality products suited for electrosurgery and microsurgery. The instruments are crafted from lightweight, non-magnetic titanium, allowing for both disposable and reusable options during surgical procedures. In addition to its product offerings, the company also provides surgical instrument repair and restoration services. Kogent Surgical distributes its products worldwide and aims to deliver superior service and cost-effective solutions to its customers.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

FocalCast offers a range of interactive web-based market research platforms for global brands and marketing agencies. FocalCast was founded by Devin Turner and Charlie Beckwith in September 2013 and is based in St Louis, Missouri.

Radialogica is a healthcare information technology company that provides software solutions for radiation oncology and the healthcare market. It offers fullAccess, an integrated radiotherapy data display, communication, and analysis platform that enables clinicians across the continuum of care to access, analyze, and share radiotherapy treatment plans, diagnostic images, and other patient data. The company’s platform consists of various licensing modules, including fullView, a vendor-independent RT visualization environment that allows clinicians to view images and treatment plans across various radiotherapy treatment modalities, delivery devices, and planning systems; fullReport tools to analyze and benchmark treatment plans, and automatically extract user-defined dosimetric parameters for retrospective analysis; and fullExchange tools to annotate, package, and share diagnostic images and treatment plans with clinicians and other vested stakeholders inside and outside the clinic. It serves physicians, physicists, dosimetrists, payers, and patients in the United States. The company was incorporated in 2011 and is based in Clayton, Missouri.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

CoverCress Inc. is a biotechnology company based in St. Louis, Missouri, focused on developing and commercializing field pennycress as an oilseed crop. Founded in 2013, the company aims to produce oil for industrial and renewable fuels, as well as meal for nutritious livestock feed. CoverCress specializes in crop breeding services that enhance soil cover during corn harvest and soybean planting, allowing farmers to maximize yields through sustainable agricultural practices. The company is dedicated to utilizing low-input methods to create a feedstock for low carbon intensity biofuels, contributing to more efficient and environmentally friendly agricultural solutions.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

RNAgri is a company based in St. Louis, Missouri, that specializes in innovative technology for producing ribonucleic acid (RNA). Founded in 2011, the company focuses on addressing the challenges associated with the large-scale production of exogenous RNA interference (RNAi) products. By utilizing a large-scale fermentation process, RNAgri enables farmers to enhance the protection and growth of their crops and livestock through the cost-efficient production of RNA. This technology aims to improve agricultural practices and contribute to more sustainable farming solutions.

GeneriCo, LLC is a pharmaceutical company that specializes in the development and marketing of generic drugs. Founded in 2013 and headquartered in Saint Louis, Missouri, with additional offices in Bengaluru, Italy, and South Korea, GeneriCo focuses on niche generic pharmaceuticals that are often overlooked by larger competitors. The company targets foundational medicines in key therapeutic areas, including cardiovascular health, pain management, central nervous system disorders, oncology, and aging-related conditions. GeneriCo distinguishes itself through its expertise in complex formulations and embedded drug delivery technologies, addressing market needs that are typically neglected by mid-sized and large generic firms. The company's global reach enables it to serve a diverse customer base.

RNAgri is a company based in St. Louis, Missouri, that specializes in innovative technology for producing ribonucleic acid (RNA). Founded in 2011, the company focuses on addressing the challenges associated with the large-scale production of exogenous RNA interference (RNAi) products. By utilizing a large-scale fermentation process, RNAgri enables farmers to enhance the protection and growth of their crops and livestock through the cost-efficient production of RNA. This technology aims to improve agricultural practices and contribute to more sustainable farming solutions.

ImmunoPhotonics, Inc. is a biotechnology company focused on developing innovative immunotherapy treatments for cancer, specifically targeting metastatic solid tumors. Founded in 2008 and located in Columbia, Missouri, the company has created a proprietary drug product designed to function as a minimally invasive therapeutic cancer vaccine. This product is administered through intratumoral injection following tumor ablation, leveraging tumor-associated neoantigens to stimulate a systemic anti-tumor immune response. By transforming the process of tumor ablation into a therapeutic approach, ImmunoPhotonics aims to enhance treatment options for patients with late-stage metastatic cancers. The company has also established a strategic partnership with Veterinary Cancer Therapeutics, LLC to further its mission in cancer treatment.

Epharmix is a digital healthcare company that creates clinically validated and condition-specific communication tools. It helps care teams automatically monitor underserved patients to improve care & reduce workload with interventions proven to impact engagement and outcomes. It was founded in 2015 and headquartered in St Louis, Missouri.

Elira, Inc. is a neurostimulation company based in St. Louis, Missouri, founded in 2015. The company specializes in developing a drug-free wearable device aimed at helping overweight adults manage their weight by suppressing appetite. This innovative device offers a non-invasive method to modulate the central nervous system, providing users with a means to gain control over their eating habits. By effectively reducing appetite, Elira's technology supports individuals in achieving their health and lifestyle goals.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

Adarza BioSystems is an early-stage medical diagnostics company based in St. Louis, Missouri, founded in 2008. The company specializes in developing a rapid and label-free biological assay platform that measures clinical and point-of-care samples. This innovative platform employs diagnostic arrayed imaging reflectometry (AIR) to enable the simultaneous detection of hundreds of analytes from a single drop of fluid, allowing healthcare professionals to conduct sophisticated tests with high sensitivity and specificity. By significantly reducing the time required for testing, Adarza BioSystems aims to enhance diagnostic capabilities in various healthcare settings.

Elemental Enzymes Inc. is a manufacturer of specialized enzymes designed for optimal performance in challenging environments, both in agriculture and industrial applications. The company produces a diverse range of enzymes, including those that degrade cellulose and starches for fuel production, and stable enzymes that provide eco-friendly alternatives to harsh chemicals used in processes like fracking. Additionally, Elemental Enzymes develops solutions for capturing and storing carbon dioxide and for breaking down proteins and antibiotics to prevent contamination of water supplies. The company also offers customized enzyme solutions tailored to address specific environmental contaminants, as well as enzymes for various non-environmental applications. Founded in 2011 and based in Columbia, Missouri, Elemental Enzymes was previously known as Spogen Biotech, Inc. and leverages patented technologies and scientific advancements to meet the evolving needs of its customers.

Akermin is based in St. Louis, Missouri, and was formed in 2004 to commercialize breakthrough stabilized enzyme technology invented at Saint Louis University. In 2008, Akermin demonstrated its prototype of a fully functioning biofuel cell operating on methanol fuel and using stabilized laccase to replace the metal catalyst in conventional cathodes. Commercial applications in wireless sensors and military uses are their primary focus. Development for the use of stabilized enzymes in the food processing, biofuels, chemical, and pharmaceutical industries is under way.

Tunespeak, LLC operates a musician-to-fan loyalty platform that rewards users for engaging with music and related content. Founded in 2011 and based in St. Louis, Missouri, the platform allows users to earn points by listening to music, watching videos, viewing photos, and sharing content with friends. Users can accumulate points not only for their own activity but also for enabling their friends to participate in contests or raffles for every song, picture, and video shared. Through this unique engagement model, Tunespeak aims to enhance the connection between musicians and their fans while offering incentives such as tickets, experiences, and merchandise.

BenchmarkONE develops sales and marketing automation software tailored for small and mid-sized businesses. The company offers an integrated platform that includes customer relationship management (CRM) tools and sales automation features, allowing users to monitor contacts' activities, track deals, manage communications, and segment their audience. Additionally, BenchmarkONE provides email marketing capabilities with a user-friendly drag-and-drop email builder and marketing automation tools designed to engage visitors, prioritize leads, and optimize campaign investments. Originally known as Hatchbuck, Inc., the company rebranded to BenchmarkONE in June 2020 and has been operational since 2010, with its headquarters in St. Louis, Missouri. As of September 2019, BenchmarkONE functions as a subsidiary of Benchmark Internet Group, LLC.

NeuroLutions Inc. is a company based in St. Louis, Missouri, focused on developing brain-computer interface (BCI) devices aimed at restoring functions for patients disabled due to neurological injuries, particularly stroke survivors. Founded in 2007, NeuroLutions employs non-invasive electroencephalography (EEG) technology to capture brain activity without the need for implanted electrodes. The EEG data is wirelessly transmitted to a tablet, where it is analyzed to interpret the patient's intended muscle movements. This innovative approach enables users to facilitate muscle re-education and helps maintain or improve their range of motion, thereby enhancing rehabilitation outcomes for individuals with movement impairments.

Kypha Inc. is a life sciences company focused on developing and commercializing in-vitro diagnostic biomarker tests for inflammation and autoimmune disorders. Based in St. Louis, Missouri, the company offers the COMP ACT System, which enhances the monitoring and treatment of various health conditions, including lupus, stroke, traumatic brain injury, preeclampsia, infection, kidney disease, and transplant rejection. Kypha aims to provide rapid and accurate assessments of inflammation levels, enabling healthcare professionals to make timely and informed clinical decisions. With a core team supported by scientific advisors and clinical collaborators, Kypha has successfully secured federal grants and raised private capital to advance its diagnostic products toward regulatory approval and market launch. The company's technology is designed for scalability, facilitating testing in diverse settings from home health to clinical laboratories, ultimately improving patient outcomes through timely intervention.

Euclises Pharmaceuticals, Inc. is engaged in the research, development, and commercialization of innovative medicines targeting inflammation and oncology. Founded in 2011 and headquartered in Saint Louis, Missouri, the company focuses on creating novel pain and cancer medications that promise enhanced safety profiles compared to current therapies. The firm is built on pioneering inventions by Dr. John Talley, a renowned medicinal chemist known for developing Celebrex among other approved drugs. Euclises aims to introduce new compounds that provide improved efficacy and safety, positioning itself as a leader in the pharmaceutical industry. The company operates from the BioGenerator Accelerator Labs, where it continues to advance its research initiatives.

Bonfyre Inc. is an employee engagement platform founded in 2013 and based in Saint Louis, Missouri. The company focuses on transforming workplace culture by providing technology that enhances employee recognition, communication, feedback, and event management. Its mobile-first platform offers real-time communication tools such as announcements, targeted broadcasts, and pop surveys, which help organizations foster camaraderie, align their culture, and gather valuable HR insights. By modernizing employee communications, Bonfyre enables companies to build stronger relationships and increase engagement, ultimately promoting a collaborative and innovative work environment.

Traxxsson is a biotechnology company that develops diagnostics for cancer using protein biomarkers. It uses a proprietary panel of biomarkers to identify at-risk patients who have questionable radiology images. It has three tests: PRO CancSure to identify prostate cancer patients in need of aggressive treatment, BRE CancSure to confirm the presence of breast cancer in women with positive mammograms, and LNG CancSure to confirm the presence of lung cancer in patients with positive low-density CAT scan results. The company was founded in 2009 and is based in St. Louis, Missouri.

Euphrates Vascular is a medical technology company based in St. Louis, Missouri, focused on developing innovative solutions for the treatment of stroke, heart disease, and other related conditions. The company's flagship product, the magnetically-enhanced diffusion (MED) system, employs advanced magnet-based technology to accelerate the dissolution of blood clots, offering a faster delivery of FDA-approved clot-busting medications compared to traditional methods. This technology aims to significantly reduce mortality rates associated with strokes and heart disease. In addition to the MED system, Euphrates Vascular offers MED MicroBeads, which facilitate the rapid delivery of selected therapeutic agents to blood clots, and a touch screen-operated MED Workstation for enhanced user interaction. Founded by physicists with extensive experience in medical technology, the company continues to attract interest from investors and media for its groundbreaking contributions to cardiovascular care.

Katalyst Surgical, LLC provides titanium ophthalmic surgical instruments. It offers cannulas, forceps, hooks/manipulators, lasik products, needle holders, phaco choppers, scissors, speculum, and related products online. Katalyst Surgical, LLC was incorporated in 2010 and is based in Chesterfield, Missouri.

Akermin is based in St. Louis, Missouri, and was formed in 2004 to commercialize breakthrough stabilized enzyme technology invented at Saint Louis University. In 2008, Akermin demonstrated its prototype of a fully functioning biofuel cell operating on methanol fuel and using stabilized laccase to replace the metal catalyst in conventional cathodes. Commercial applications in wireless sensors and military uses are their primary focus. Development for the use of stabilized enzymes in the food processing, biofuels, chemical, and pharmaceutical industries is under way.

Appistry Inc. specializes in developing bioinformatics tools, cloud services, and software solutions to facilitate genomically enhanced medicine for healthcare institutions. The company provides a range of products, including Appistry CloudDx, which supports patient-centered translational research and the integration of genome-scale tests into routine patient care. Their offerings also include CloudDx Translational, a solution for centralizing data and communication across various research projects, as well as tools for analyzing whole genomes, exomes, and tumor-normal pair data. Additionally, Appistry's GenomePilot and Genome Analysis Toolkit help bioinformaticians and researchers navigate complex next-generation sequencing (NGS) analysis processes and derive actionable insights from NGS datasets. The Cancer Genome Analysis Suite and Variant Annotation and Analysis Suite further enhance the company's capabilities by providing integrated tools for addressing challenges in cancer genomics and variant analysis. Founded in 2001 and based in St. Louis, Missouri, Appistry was previously known as Tsunami Research, Inc. before rebranding in 2005.