Ben Franklin Technology Partners of Southeastern Pennsylvania is a technology-focused capital provider based in Philadelphia, founded in 1982 to advance the region's technology community. The organization funds and supports technology companies across Pennsylvania, especially in information technology, health, and physical sciences, investing substantial capital in early-stage and established ventures. It has invested over 170 million dollars in more than 1,750 regional technology companies and has launched university-industry partnerships to translate scientific discoveries into commercial products, while seeding regional initiatives that strengthen the entrepreneurial ecosystem and create jobs.

Established in 1999, Innovation Works is a prominent investor in Southwestern Pennsylvania's technology sector. It provides capital and resources to early-stage companies with high growth potential and significant regional impact, particularly focusing on robotics, AI, medical devices, retail technologies, and enterprise software.

BioAdvance is a venture capital firm based in Conshohocken, Pennsylvania, that funds early‑stage life sciences and healthcare companies in the mid-Atlantic region, including Southeastern Pennsylvania. It backs therapeutics, medical devices, diagnostics and platform technologies aimed at human health, through its Greenhouse Fund, a $50 million vehicle created to support seed and pre‑seed investments. Since its inception, BioAdvance has committed more than $40 million to more than 50 seed‑stage and 17 pre‑seed companies, with portfolio activity spanning diseases such as Alzheimer's, cancer, obesity, GI disorders, and neurological and respiratory illnesses.

Robin Hood Ventures is an angel investor group based in Philadelphia, Pennsylvania, established in 1999. The organization focuses on early-stage, high-growth companies primarily in the Greater Philadelphia region. It provides capital, mentoring, and valuable connections to assist entrepreneurs in building successful businesses. Typically, Robin Hood Ventures invests between $250,000 and $500,000, often collaborating with other angel investors, institutions, and venture capitalists within its network. The firm has a diverse investment portfolio, spanning various sectors, including information technology services, software, life sciences, hard technology, consumer products, and financial technology. Since its inception, Robin Hood Ventures has invested in over 45 companies, emphasizing a hands-on approach to helping businesses achieve their potential.

Aspire Ventures is a venture capital investment firm established in 2014 and headquartered in Lancaster, Pennsylvania. The firm specializes in transforming healthcare through innovative technologies, focusing on areas such as artificial intelligence, information technology, and the Internet of Things (IoT). Aspire Ventures aims to address significant challenges in the healthcare sector by leveraging its capital, intellectual property, and domain expertise to support and develop emerging companies in these fields.

DreamIt Ventures is a Philadelphia-based venture capital firm founded in 2008 that backs startups across healthcare, technology, cybersecurity, consumer products and services, and real estate technology. The firm operates DreamIt accelerator programs, providing an intense three to six month experience that combines seed funding, mentorship, office space, and access to customers, partners, and investors to accelerate product development and go-to-market. DreamIt has supported more than 320 startups, including LevelUp, SeatGeek, HouseParty and Redox, with several achieving exits or substantial growth, reflecting a track record of helping portfolio companies scale. The firm emphasizes hands-on customer validation through Customer Sprints and Investor Sprints to de-risk growth and attract partnerships, focusing on ventures with traction or pilots ready to scale in the United States.

Alumni Ventures Group is a venture capital firm based in Manchester, New Hampshire, with offices across North America. It provides access to venture investing for individual accredited investors, particularly alumni networks, by offering diversified portfolios of venture opportunities and allowing members to invest alongside fellow alumni in ventures led by peers. The firm backs early-stage and later-stage opportunities across technology, consumer, healthcare, financial services, and other sectors, with a sector- and geography-agnostic approach. It typically invests between $10,000 and $3 million per deal and emphasizes the involvement of alumni connections and an institutional lead investor in opportunities. Alumni Ventures also offers focused funds to broaden participation, enabling accredited investors to access venture portfolios diversified by type, sector, stage, and geography. The model aims to democratize access to venture capital while maintaining rigorous selection standards through alumni networks.

Mountain State Capital, established in 2018, is a venture capital firm headquartered in Morgantown, West Virginia, with an additional office in Pittsburgh, Pennsylvania. The company specializes in seed and early-stage investments, focusing on technology companies based in the Greater Appalachia region of the United States. It typically invests between $250,000 and $500,000 in companies, targeting information technology and healthcare sectors. Mountain State Capital operates as a Small Business Investment Company, providing early-stage risk capital to high-growth companies in the region.

Founded in 2008, AlphaLab is a nationally ranked startup accelerator based in Pittsburgh, PA. It invests seed capital and mentorship to early-stage technology companies, focusing on software, web services, gaming, mobile, and consumer internet sectors. As of one of the first ten accelerator programs worldwide, AlphaLab has invested in and worked with 113 companies, including notable acquisitions like NoWait (acquired by Yelp) and Black Locus (acquired by Home Depot).

Pittsburgh Life Sciences Greenhouse, established in 2002, is a Pittsburgh-based economic development agency dedicated to fostering the life sciences industry in western Pennsylvania. It invests in early-stage life sciences and biosciences companies, focusing on biotechnology tools, diagnostics, healthcare IT, medical devices, and therapeutics. The firm provides not only capital, ranging from $0.1 million to $10 million, but also customized business growth services and support for company formation. Pittsburgh Life Sciences Greenhouse seeks to invest in companies planning to relocate to Pennsylvania, with a preference for the Pittsburgh area.

Founded in 2016, Red & Blue Ventures is a privately owned venture capital fund investing in seed and early-stage technology companies with ties to the University of Pennsylvania.

Founded in 1994, Adams Capital Management is a venture capital firm based in Pittsburgh, Pennsylvania. It specializes in early-stage investments in applied technology companies, with a focus on information technology and networking infrastructure sectors.

Founded in 2005, MentorTech Ventures is a venture capital firm based in Philadelphia that invests in seed- and early-stage companies from the University of Pennsylvania ecosystem. These companies typically have key founders or managers who are students, faculty members, or alumni of the university.

Gabriel Investments is a venture capital firm founded in 2010 and based in Philadelphia, Pennsylvania. It focuses on early-stage investment opportunities, primarily targeting companies in the pre-revenue and proof of concept phases with significant growth potential. The firm emphasizes support for businesses in various sectors, including direct marketing, software, distribution, communications, and technology. Gabriel Investments distinguishes itself by prioritizing investments in both people and innovative ideas, aiming for long-term ownership rather than quick returns. In addition to providing capital, the firm leverages the personal experiences and expertise of its members to assist entrepreneurs in refining their business plans, building management teams, developing go-to-market strategies, and forging strategic partnerships.

Safeguard Scientifics, Inc., established in 1953, is a growth capital firm headquartered in Radnor, Pennsylvania, with an additional office in Weston, Massachusetts. The company specializes in providing growth capital and operational support to technology companies operating within the healthcare, financial services, and digital media sectors. Safeguard typically invests between $5 million and $25 million in growth equity financing and between $5 million and $10 million in early-stage financing. It prefers to be the largest shareholder in its portfolio companies, usually taking a 20% to 50% stake, and often seeks a Board seat. The firm focuses on companies with proprietary technology and intellectual property, and it has a history of fostering innovation and building market leaders.

Pittsburgh Equity Partners is a venture capital investment firm based in Bridgeville, Pennsylvania, established in 2009 to support early-stage technology companies in Western Pennsylvania, with an emphasis on life sciences and information technology. The firm targets promising startups in the technology and information technology sectors, providing capital and strategic support to help them grow in a region identified as underserved for early-stage funding. By focusing on Western Pennsylvania, Pittsburgh Equity Partners seeks to strengthen the regional technology ecosystem and foster companies with potential for scalable growth.

Founded in 1995, SOSV is a global venture capital firm headquartered in New Jersey. It focuses on seed-to-growth stage investments in deep tech innovations, primarily in bio-tech/life sciences and hardware/robotics sectors, with a commitment to human and planetary health.

GE Equity invests globally across various sectors, focusing on established companies with high growth potential. It takes minority ownership positions and offers growth capital, buy-out co-investments, secondary direct purchases, recapitalizations, and LP investments.

Draper Triangle is a venture capital firm founded in 1999, specializing in early-stage investments. Based in Pittsburgh, Pennsylvania, with additional offices in Midwest states, the firm focuses on technology companies, particularly in software, digital media, robotics, and medical devices. Draper Triangle seeks to invest between $250,000 and $2 million initially, aiming for companies with high growth potential.

First Round Capital is a San Francisco-based venture capital firm that concentrates on seed- and early-stage investments, often supporting pre-revenue startups across sectors including enterprise software, fintech, healthcare, consumer, hardware, artificial intelligence, and web3. The firm emphasizes a community-driven approach, providing founder-focused services, mentorship, and access to a broad founder network to help companies grow. It operates nationally with offices in San Francisco and New York and seeks to take an active role in portfolio companies to aid scaling and access to follow-on funding.

Science Center Ventures, based in Philadelphia, specializes in investing in life sciences and technology companies. It is part of Science Center, a hub for entrepreneurial activity and healthcare innovation.

Established in 1983, this organization supports early-stage technology-based companies and small manufacturers across a 32-county region in Pennsylvania. It provides funding and business support services to foster growth and create high-paying jobs.

Devon Park Bioventures, based in Wayne, Pennsylvania, is a venture capital firm specializing in investments in the life sciences sector. Founded in 2006, the company focuses on identifying and supporting innovative companies involved in therapeutics, medical devices, diagnostics, and drug discovery technologies. With its strategic location in the Philadelphia metropolitan area, Devon Park Bioventures is well-positioned to engage with a multitude of leading organizations in the healthcare and biotechnology fields. The firm is dedicated to fostering advancements that can enhance patient care and drive growth in the life sciences industry.

Founded in 2013, Riverfront Ventures is a venture capital firm based in Pittsburgh, Pennsylvania. It specializes in seed and early-stage investments, focusing on companies with high growth potential across sectors such as software, healthcare, life science, and robotics within the Pennsylvania region.

New Enterprise Associates is a venture capital firm founded in 1977 and based in Menlo Park, California, with offices in the United States, India and China. It makes investments across technology and healthcare startups at multiple stages, from seed to growth, including software, cloud, data, internet services, fintech, AI, e-commerce, and enterprise technology, as well as healthcare information technology, life sciences, medical devices, and biopharma. It also considers energy technology and infrastructure opportunities, such as solar, batteries and smart grids. The firm pursues a global approach, with activity in the United States, Asia and other regions, and supports companies through rounds of financing ranging from small to sizable investments as they scale. NEA focuses on building portfolios in software, IT services, consumer technology, and healthcare technology, backing ambitious entrepreneurs across sectors and geographies.

EOS Venture Partners is a venture capital firm specializing in Series A, mid venture, early, later stage and growth stage companies. The firm seeks to invest in InsurTech sector with a focus on Insurance, b2b, b2b2c, Technology and Innovative companies. EOS Venture Partners was founded in 2016 and is based in London, United Kingdom with additional offices in Philadelphia, Pennsylvania, Guernsey, Channel Islands, New York, New York and Hong Kong.

Aperture Venture Capital, founded in 2021 and based in Philadelphia, Pennsylvania, is a venture capital firm that focuses on investing in diverse founders and multicultural ventures. The firm targets startup companies in the fintech, enterprise, and consumer sectors, with particular interest in areas such as insurance, software as a service (SaaS), security and identity, infrastructure, lending, and banking. By leveraging financial innovation, Aperture aims to support individuals and businesses in achieving growth and success.

Sixers Innovation Lab is a venture capital firm and accelerator based in Camden, New Jersey. It runs the Sixers Innovation Lab Crafted by Kimball program to support rapidly growing, early-stage consumer product and entertainment-focused startups by providing consulting, access to industry experts, branding and legal services, and investment opportunities, along with office space furnished by Kimball Office, meals and housing in the Philadelphia area, and opportunities to pitch to investors. The organization also manages an early-stage fund that targets investments in media, business products and services, consumer non-durables, gaming and esport sectors.

SustainVC is a venture capital firm specializing in early-stage impact investing. It focuses on companies addressing climate change and sustainability, equality and empowerment, health, and education. Based in Durham, New York, with additional offices in Boston and Philadelphia, the firm invests between $0.25 million to $1 million in early-stage companies.

Founded in 2019, Reinforced Ventures is a venture capital firm based in Pittsburgh, Pennsylvania. It focuses on investing in seed or pre-seed stage startups operating within the robotics, software, autonomous systems, and biotechnology sectors.

412 Venture Fund is a venture capital firm based in Pittsburgh, Pennsylvania, United States. It invests in early‑stage technology and technology‑enabled companies across sectors including artificial intelligence and machine learning, B2B software as a service, cybersecurity, robotics, advanced materials, sensors, and healthcare, with a typical investment capacity around two million dollars. The firm also seeks impact investments in diversity and inclusion.

Founded in 2013, Keiretsu Capital is a Seattle-based private equity firm that invests in high-quality emerging companies. It focuses on life science, healthcare, technology, and real estate sectors, aiming to provide significant capital appreciation through strategic investments.

Ground Up Ventures is an early stage venture capital firm established in 2017 and based in Philadelphia, Pennsylvania. The firm specializes in investing in pre-seed and seed stage startups, primarily focusing on companies within the technology sector. Ground Up Ventures targets investments in startups located in the United States and Israel, aiming to support innovative ideas and foster growth in emerging businesses.

Tech Council Ventures is a Summit, New Jersey-based venture capital firm that makes early-stage investments across the United States. It partners with entrepreneurs to build leading-edge, technology-driven companies and seeks to generate strong returns for investors while contributing to economic growth in communities. The firm focuses on seed and Series A and expansion-stage opportunities spanning technology, biotech and life sciences, enterprise technology, media, telecom, cleantech, edtech, and healthcare.

Founded in 2015, FJ Labs is a New York-based venture capital firm focusing on stage-agnostic investments in marketplaces and consumer-facing startups. Their investment range varies from $50,000 to $5,000,000, typically at seed or series A stages.

Rittenhouse Ventures is a Philadelphia-based early-stage venture capital firm that backs capital-efficient technology companies in the Mid-Atlantic region, with a focus on healthcare information technology and pharmaceutical IT. The firm also invests in technology-enabled services and other IT-enabled sectors such as financial services IT and outsourced business services. It partners with management teams of B2B software, AI and other tech-enabled companies, often in rounds around one to five million dollars, supporting companies that generate modest revenue and have growth potential. Rittenhouse emphasizes hands-on operational support and access to its regional network to help portfolio companies scale, targeting underserved markets within Pennsylvania and the broader Mid-Atlantic. The firm collaborates with regional investors to foster sustainable growth and market leadership.

Founded in 2017, Next Act Fund is an angel investment group based in Pittsburgh, Pennsylvania. It focuses on investing in early-stage, women-owned or led companies within the Greater Pittsburgh region.

MissionOG is a Philadelphia-based venture capital and private equity firm that partners with high-growth business-to-business companies in fintech, financial services, data platforms, and software. It provides capital and leverages a broad network of industry experts to accelerate growth and guide portfolio companies toward strategic outcomes, including acquisitions. Founded in 2012, MissionOG is led by a team with experience in building and scaling companies through multiple growth stages. The firm focuses on early-stage and growth investments in sectors where it has operating expertise, including financial services, payments, software, and data-enabled technologies.

Founded in 1994, Emerald Development Managers is a New York-based venture capital firm focusing on early-stage growth equity investments. They primarily invest in technology companies, with a focus on sectors such as life sciences, SaaS, biotech, healthcare IT, cleantech, industrial tech, enterprise software, cybersecurity, and sustainability.

Bentley Systems develops software for infrastructure engineering professionals, enabling design, construction, and operations management. Its solutions include MicroStation for modeling and visualization, ProjectWise for project information management, AssetWise for asset lifecycle management, and SYNCHRO XR for immersive digital construction experiences. Bentley serves engineers, architects, contractors, and operators, with a focus on core specialty areas like bridge or rail design.

Founded in 2010, New Rhein is a venture capital firm focused on healthcare therapeutics and medical devices. It invests in businesses that leverage proven products for new applications, such as new indications or dosage forms. The firm compiles syndicates of operationally-focused investors to support portfolio companies across development, regulatory, marketing, and manufacturing aspects.

1855 Capital Partners is a seed and early-stage venture capital firm based in State College, Pennsylvania. It engages with Penn State University's faculty, staff, students, and the extensive alumni network to source and support portfolio companies. The firm backs early-stage ventures across financial services, information technology, agriculture technology, and gaming and esports, prioritizing opportunities connected to the Penn State ecosystem.

Founded in 2007, Originate Ventures is a venture capital firm based in Bethlehem, Pennsylvania. It specializes in early-stage investments, focusing on product and services companies operating in healthcare, consumer, information technology, software, web-based, and commercial products sectors within the Mid-Atlantic region.

The Robotics Hub, founded in 2015 and based in Pittsburgh, Pennsylvania, is a pioneering venture capital firm focused on developing companies from emerging robotics advancements. It aims to transform innovative ideas into impactful organizations that can significantly alter daily life and work. The firm specializes in sectors such as information technology, manufacturing, robotics, drones, artificial intelligence, and machine learning. By leveraging unique resources and providing active support akin to that of a cofounder, The Robotics Hub concentrates its efforts on rapidly identifying and nurturing viable concepts, guiding them swiftly through their growth phases.

Fusion Fund is a Palo Alto, California-based venture capital firm that targets early-stage technology companies across the United States and Canada. The firm typically backs pre-seed, seed, and Series A rounds and focuses on sectors including healthcare technology, enterprise AI, industrial technology, information technology, and complementary areas such as the Internet of Things, robotics and drones, cybersecurity, and blockchain. It emphasizes backing companies with strong technical barriers and defensible advantages capable of global disruption, leveraging a blend of technical and entrepreneurial expertise to support founders aiming for scalable growth.

Activate Venture Partners is a New York–based venture capital firm focused on early-stage and growth investments in software, data, and technology-enabled services, with a particular emphasis on digital health and healthcare IT, fintech, and enterprise technology. The firm backs technology-enabled service businesses offering software as a service, data-as-a-service, mobile apps, and related platforms, and seeks to invest in companies serving providers, payors, biopharmaceutical firms, and patients. It targets opportunities in the Northeast and Mid-Atlantic, especially the Greater New York area, New Jersey, Connecticut, Eastern Pennsylvania, and neighboring markets, and tends to invest in initial rounds ranging from roughly $0.75 million to $3 million, preferring deals that require under $5 million to reach profitability. Activate often leads or co-leads investments, takes a board seat, and assists with follow-on equity rounds and financing. The firm has a history of digital health activity and software and data provenance across its portfolio, underscoring its focus on scalable technology-enabled solutions rather than medical devices or drugs.

Andreessen Horowitz is a venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz and based in Menlo Park, California. It funds startups across the entire lifecycle, from seed to growth, with a broad focus on software and technology-enabled businesses. The firm backs companies in software, cloud infrastructure, digital platforms, data storage, and mobile and Internet services, as well as sectors at the intersection of technology with life sciences, such as bio healthcare and computational medicine. Its investments span artificial intelligence, fintech, consumer and enterprise software, crypto and blockchain, cybersecurity, and related infrastructure. Through strategic guidance and a hands-on approach, the firm aims to help portfolio companies scale and innovate.

Leading Edge Ventures is a Delaware-based venture capital firm focused on seed and early-stage technology companies in the United States, with a primary emphasis on the Mid-Atlantic region. It seeks opportunities across information technology, enterprise infrastructure and applications, healthcare, medical devices, materials, core science, and other high-growth markets. The firm typically makes initial investments ranging from $50,000 to $250,000 per company and can participate up to $750,000 per company, either as a sole investor or as part of syndicates. Headquartered in Newark, Delaware, it maintains an additional office in Bethlehem, Pennsylvania.

Founded in 2007, SRI Capital is a venture capital firm headquartered in Philadelphia with operations in India. The company focuses on early-stage investments in innovative startups primarily in India and the US, with an interest in enterprise software, deep tech, and consumer market solutions.

US Innovative Technology Fund is a Pittsburgh-based venture capital firm founded in 2022 that backs early- and growth-stage technology companies in the United States. The firm targets sectors including information technology, artificial intelligence, cloud computing, space technology, cybersecurity, biotechnology, defense technology, logistics and supply chain technologies, advanced manufacturing, and healthcare, with a preference for B2B and business services applicants. It focuses on companies developing commercial applications and defense-related technologies, including quantum computing and machine learning. The firm aims to support companies through strategic guidance, capital, and networks to accelerate growth and product deployment within the U.S. market.