New Enterprise Associates

Intact Vascular, Inc. is a medical device company based in Wayne, Pennsylvania, specializing in the development of minimally invasive products for peripheral vascular procedures. Founded in 2011, the company is known for its Tack Endovascular System, which aims to enhance the results of peripheral balloon angioplasty in treating peripheral arterial disease (PAD) and critical limb ischemia (CLI). Intact Vascular focuses on creating safe and effective solutions that improve clinical outcomes and quality of life for patients with vascular diseases, while also providing physicians with innovative treatment options.

Vesper Medical, Inc. is a medical device company based in Wayne, Pennsylvania, founded in 2016. The company specializes in the development of minimally invasive peripheral vascular products aimed at treating patients with deep venous disease. Its primary offering is the Vesper DUO Venous Stent System, designed specifically for venous stenting. This system features a unique combination of strength and flexibility to address the complex anatomical challenges encountered in the iliac and femoral veins. Vesper Medical is dedicated to creating safe, effective, and user-friendly products that enhance patient care and support healthcare providers in improving patient outcomes in venous treatment.

Founded in 2009, Lungpacer Medical is a medical device company based in Vancouver, Canada. It specializes in developing therapeutic solutions to preserve and restore the strength of the diaphragm muscle in critically ill patients requiring mechanical ventilation. The company's flagship product, the Lungpacer DPT System, uses a minimally invasive, transvascular nerve stimulation approach to activate the diaphragm, potentially improving patient outcomes and reducing hospital care costs.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

PhaseBio Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing novel therapies for cardiopulmonary diseases. Its lead product candidate, PB2452, is a reversal agent for the antiplatelet drug ticagrelor, intended to manage uncontrolled bleeding events or urgent surgeries. PhaseBio is also developing PB1046 for pulmonary arterial hypertension and PB6440 for resistant hypertension.

Vesper Medical, Inc. is a medical device company based in Wayne, Pennsylvania, founded in 2016. The company specializes in the development of minimally invasive peripheral vascular products aimed at treating patients with deep venous disease. Its primary offering is the Vesper DUO Venous Stent System, designed specifically for venous stenting. This system features a unique combination of strength and flexibility to address the complex anatomical challenges encountered in the iliac and femoral veins. Vesper Medical is dedicated to creating safe, effective, and user-friendly products that enhance patient care and support healthcare providers in improving patient outcomes in venous treatment.

Intact Vascular, Inc. is a medical device company based in Wayne, Pennsylvania, specializing in the development of minimally invasive products for peripheral vascular procedures. Founded in 2011, the company is known for its Tack Endovascular System, which aims to enhance the results of peripheral balloon angioplasty in treating peripheral arterial disease (PAD) and critical limb ischemia (CLI). Intact Vascular focuses on creating safe and effective solutions that improve clinical outcomes and quality of life for patients with vascular diseases, while also providing physicians with innovative treatment options.

Complexa, Inc. is a biopharmaceutical company focused on developing innovative medicines for severe and life-threatening conditions related to fibrosis and inflammation. Founded in 2008 and based in Berwyn, Pennsylvania, the company specializes in researching endogenous human cell signaling technologies to address a range of inflammatory, fibrotic, and central nervous system diseases. Its proprietary technology centers on the synthesis and therapeutic use of endogenous nitro-fatty acids, which serve as cell-signaling agents that modulate key inflammatory pathways. Notable among its developments is CXA-10, an oral nitrated fatty acid compound aimed at treating conditions such as focal segmental glomerulosclerosis and pulmonary arterial hypertension. Through its research efforts, Complexa aims to enhance existing anti-inflammatory and metabolic signaling mechanisms to support the resolution and repair of both acute and chronic tissue injuries.

Intact Vascular, Inc. is a medical device company based in Wayne, Pennsylvania, specializing in the development of minimally invasive products for peripheral vascular procedures. Founded in 2011, the company is known for its Tack Endovascular System, which aims to enhance the results of peripheral balloon angioplasty in treating peripheral arterial disease (PAD) and critical limb ischemia (CLI). Intact Vascular focuses on creating safe and effective solutions that improve clinical outcomes and quality of life for patients with vascular diseases, while also providing physicians with innovative treatment options.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Curalate, Inc. is a technology company that operates an online platform focused on enhancing the connection between visual content and e-commerce. Founded in 2011 and based in Philadelphia, with additional offices in New York, Seattle, and London, the company enables brands to convert images and videos into interactive digital storefronts across various online channels, including social media and advertisements. Curalate's platform offers tools for brands to automate content posting, track social media engagement, and gain insights into campaign performance, competitors, and influencers. By leveraging image recognition algorithms, Curalate facilitates a seamless transition from consumer discovery of products to actual purchases, working with prominent brands such as Gap, Neiman Marcus, and Sephora to drive revenue through visual-driven commerce. Curalate, previously known as Storably, became a subsidiary of Bazaarvoice in July 2020.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Duolingo is a leading language learning platform offering courses in nearly 40 languages. With over 30 million active users, it provides free language education through its app and website, along with premium features for a fee. Duolingo also offers 'Duolingo for Schools' to help educators track students' progress.

Intact Vascular, Inc. is a medical device company based in Wayne, Pennsylvania, specializing in the development of minimally invasive products for peripheral vascular procedures. Founded in 2011, the company is known for its Tack Endovascular System, which aims to enhance the results of peripheral balloon angioplasty in treating peripheral arterial disease (PAD) and critical limb ischemia (CLI). Intact Vascular focuses on creating safe and effective solutions that improve clinical outcomes and quality of life for patients with vascular diseases, while also providing physicians with innovative treatment options.

PhaseBio Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing novel therapies for cardiopulmonary diseases. Its lead product candidate, PB2452, is a reversal agent for the antiplatelet drug ticagrelor, intended to manage uncontrolled bleeding events or urgent surgeries. PhaseBio is also developing PB1046 for pulmonary arterial hypertension and PB6440 for resistant hypertension.

Strongbridge Biopharma plc is a commercial-stage biopharmaceutical company dedicated to developing and commercializing therapies for rare diseases with significant unmet medical needs. The company’s primary focus is on rare endocrine disorders, exemplified by its product candidates, Recorlev, a cortisol synthesis inhibitor currently in Phase III trials for endogenous Cushing's syndrome, and Veldoreotide, a somatostatin analog that has completed Phase II trials for acromegaly. Strongbridge also offers Keveyis, an oral carbonic anhydrase inhibitor approved for treating specific forms of periodic paralysis in the United States. Founded in 1996 and headquartered in Trevose, Pennsylvania, the company aims to leverage a concentrated prescriber base for its products and plans to utilize a targeted sales force for marketing in the U.S., European Union, and other key markets. Additionally, Strongbridge seeks to enhance its portfolio through the in-licensing or acquisition of complementary products that align with its focus on rare endocrine conditions.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Curalate, Inc. is a technology company that operates an online platform focused on enhancing the connection between visual content and e-commerce. Founded in 2011 and based in Philadelphia, with additional offices in New York, Seattle, and London, the company enables brands to convert images and videos into interactive digital storefronts across various online channels, including social media and advertisements. Curalate's platform offers tools for brands to automate content posting, track social media engagement, and gain insights into campaign performance, competitors, and influencers. By leveraging image recognition algorithms, Curalate facilitates a seamless transition from consumer discovery of products to actual purchases, working with prominent brands such as Gap, Neiman Marcus, and Sephora to drive revenue through visual-driven commerce. Curalate, previously known as Storably, became a subsidiary of Bazaarvoice in July 2020.

Duolingo is a leading language learning platform offering courses in nearly 40 languages. With over 30 million active users, it provides free language education through its app and website, along with premium features for a fee. Duolingo also offers 'Duolingo for Schools' to help educators track students' progress.

Curalate, Inc. is a technology company that operates an online platform focused on enhancing the connection between visual content and e-commerce. Founded in 2011 and based in Philadelphia, with additional offices in New York, Seattle, and London, the company enables brands to convert images and videos into interactive digital storefronts across various online channels, including social media and advertisements. Curalate's platform offers tools for brands to automate content posting, track social media engagement, and gain insights into campaign performance, competitors, and influencers. By leveraging image recognition algorithms, Curalate facilitates a seamless transition from consumer discovery of products to actual purchases, working with prominent brands such as Gap, Neiman Marcus, and Sephora to drive revenue through visual-driven commerce. Curalate, previously known as Storably, became a subsidiary of Bazaarvoice in July 2020.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Bravo Health, Inc. is a managed care organization that specializes in providing Medicare Advantage options, catering specifically to Medicare beneficiaries, including those who are dually eligible for Medicare and Medicaid. The company offers a range of plans, including special needs plans for individuals receiving institutional care or those with chronic health conditions, as well as private fee-for-service plans that allow members to choose their healthcare providers. Additionally, Bravo Health provides Part D prescription drug plans to cover medication needs. The company operates in multiple states, including Delaware, Maryland, Pennsylvania, Texas, and Washington, and has expanded its services to offer prescription drug coverage in 43 states. Founded in 1996 and headquartered in Baltimore, Maryland, Bravo Health was previously known as Elder Health, Inc.

Duolingo is a leading language learning platform offering courses in nearly 40 languages. With over 30 million active users, it provides free language education through its app and website, along with premium features for a fee. Duolingo also offers 'Duolingo for Schools' to help educators track students' progress.

PhaseBio Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing novel therapies for cardiopulmonary diseases. Its lead product candidate, PB2452, is a reversal agent for the antiplatelet drug ticagrelor, intended to manage uncontrolled bleeding events or urgent surgeries. PhaseBio is also developing PB1046 for pulmonary arterial hypertension and PB6440 for resistant hypertension.

Curalate, Inc. is a technology company that operates an online platform focused on enhancing the connection between visual content and e-commerce. Founded in 2011 and based in Philadelphia, with additional offices in New York, Seattle, and London, the company enables brands to convert images and videos into interactive digital storefronts across various online channels, including social media and advertisements. Curalate's platform offers tools for brands to automate content posting, track social media engagement, and gain insights into campaign performance, competitors, and influencers. By leveraging image recognition algorithms, Curalate facilitates a seamless transition from consumer discovery of products to actual purchases, working with prominent brands such as Gap, Neiman Marcus, and Sephora to drive revenue through visual-driven commerce. Curalate, previously known as Storably, became a subsidiary of Bazaarvoice in July 2020.

Trevena, Inc., founded in 2007 and headquartered in Chesterbrook, Pennsylvania, is a biopharmaceutical company dedicated to the development of innovative medicines for central nervous system (CNS) disorders. The company specializes in creating G protein-coupled receptor (GPCR) biased ligands, which aim to improve upon existing therapies by enhancing efficacy and reducing adverse effects. Trevena's pipeline includes several product candidates: Oliceridine injection, a mu-opioid receptor ligand completed Phase III trials for acute pain management; TRV250, a delta-opioid receptor agonist in Phase I study for migraine treatment; TRV734, a small molecule MOR ligand in Phase I study for acute and chronic pain; TRV027, currently in phase 2 clinical testing for the treatment of acute heart failure; and TRV045, an S1P modulator for managing chronic pain. Trevena has also collaborated with Imperial College London to evaluate Trv027 in Covid-19 patients.

PhaseBio Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing novel therapies for cardiopulmonary diseases. Its lead product candidate, PB2452, is a reversal agent for the antiplatelet drug ticagrelor, intended to manage uncontrolled bleeding events or urgent surgeries. PhaseBio is also developing PB1046 for pulmonary arterial hypertension and PB6440 for resistant hypertension.

Trevena, Inc., founded in 2007 and headquartered in Chesterbrook, Pennsylvania, is a biopharmaceutical company dedicated to the development of innovative medicines for central nervous system (CNS) disorders. The company specializes in creating G protein-coupled receptor (GPCR) biased ligands, which aim to improve upon existing therapies by enhancing efficacy and reducing adverse effects. Trevena's pipeline includes several product candidates: Oliceridine injection, a mu-opioid receptor ligand completed Phase III trials for acute pain management; TRV250, a delta-opioid receptor agonist in Phase I study for migraine treatment; TRV734, a small molecule MOR ligand in Phase I study for acute and chronic pain; TRV027, currently in phase 2 clinical testing for the treatment of acute heart failure; and TRV045, an S1P modulator for managing chronic pain. Trevena has also collaborated with Imperial College London to evaluate Trv027 in Covid-19 patients.

Vitae Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company headquartered in Fort Washington, Pennsylvania, that specializes in discovering and developing novel small molecule drugs aimed at addressing significant unmet medical needs. Founded in 2001, Vitae's product pipeline includes VTP-43742, currently in Phase I clinical trials for autoimmune disorders such as psoriasis and multiple sclerosis, and VTP-38543, which is in Phase IIa trials for atopic dermatitis. The company is also advancing VTP-34072 in Phase II trials for type 2 diabetes and VTP-38443 for acute coronary syndrome, as well as BI 1147560 for Alzheimer's disease. Vitae Pharmaceuticals utilizes a structure-based drug-design platform known as Contour to develop its compounds, targeting large markets with chronic conditions, including chronic kidney disease and atherosclerosis. In 2016, Vitae became a subsidiary of Allergan plc.

Rinera Networks is a professional in internet video distribution. It is based in Pittsburgh, Pennsylvania.

Vitae Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company headquartered in Fort Washington, Pennsylvania, that specializes in discovering and developing novel small molecule drugs aimed at addressing significant unmet medical needs. Founded in 2001, Vitae's product pipeline includes VTP-43742, currently in Phase I clinical trials for autoimmune disorders such as psoriasis and multiple sclerosis, and VTP-38543, which is in Phase IIa trials for atopic dermatitis. The company is also advancing VTP-34072 in Phase II trials for type 2 diabetes and VTP-38443 for acute coronary syndrome, as well as BI 1147560 for Alzheimer's disease. Vitae Pharmaceuticals utilizes a structure-based drug-design platform known as Contour to develop its compounds, targeting large markets with chronic conditions, including chronic kidney disease and atherosclerosis. In 2016, Vitae became a subsidiary of Allergan plc.

Vitae Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company headquartered in Fort Washington, Pennsylvania, that specializes in discovering and developing novel small molecule drugs aimed at addressing significant unmet medical needs. Founded in 2001, Vitae's product pipeline includes VTP-43742, currently in Phase I clinical trials for autoimmune disorders such as psoriasis and multiple sclerosis, and VTP-38543, which is in Phase IIa trials for atopic dermatitis. The company is also advancing VTP-34072 in Phase II trials for type 2 diabetes and VTP-38443 for acute coronary syndrome, as well as BI 1147560 for Alzheimer's disease. Vitae Pharmaceuticals utilizes a structure-based drug-design platform known as Contour to develop its compounds, targeting large markets with chronic conditions, including chronic kidney disease and atherosclerosis. In 2016, Vitae became a subsidiary of Allergan plc.

Laurel Networks, founded in 1999 and based in Pittsburgh, Pennsylvania, specializes in developing IP service edge routers and management solutions. The company offers a range of products, including its ST-series Service Edge Routers, which integrate Internet-class routing with multi-service support and broadband subscriber management. Additionally, the ShadeTree System Software enhances routing and switching performance, while the ShadeTree Management Suite facilitates the deployment of services for both residential and business customers. By focusing on IP-based multi-service data delivery solutions, Laurel Networks aims to address the evolving needs of the telecommunications industry.

Laurel Networks, founded in 1999 and based in Pittsburgh, Pennsylvania, specializes in developing IP service edge routers and management solutions. The company offers a range of products, including its ST-series Service Edge Routers, which integrate Internet-class routing with multi-service support and broadband subscriber management. Additionally, the ShadeTree System Software enhances routing and switching performance, while the ShadeTree Management Suite facilitates the deployment of services for both residential and business customers. By focusing on IP-based multi-service data delivery solutions, Laurel Networks aims to address the evolving needs of the telecommunications industry.

PPONEXT is a PPO services company that provides healthcare management and network services. PPONEXT offers access to a network of medical care providers, hospitals, and ancillary facilities to group health, workers' compensation, and other insurance payers in the Midwest, Texas, California, Florida, New Jersey, and Pennsylvania.