Pittsburgh Life Sciences Greenhouse

Pittsburgh Life Sciences Greenhouse (PLSG) is an economic development agency based in Pittsburgh, Pennsylvania, established in 2002. It focuses on nurturing and supporting life sciences companies in the region, particularly in biotechnology tools, diagnostics, healthcare information technology, medical devices, and therapeutics. PLSG provides capital investments and tailored business growth services to emerging biosciences enterprises, aiming to foster innovation and advancements in research and patient care. The agency seeks to attract and support companies that may relocate to Pennsylvania, investing between $0.1 million and $10 million in these ventures. By collaborating with local universities, medical institutions, and regional foundations, PLSG plays a vital role in developing the life sciences industry in western Pennsylvania.

Diana Cugliari

Managing Director of Accelerator Fund, President and CEO

Christopher Evans

Venture Partner

Past deals in Pennsylvania

Forest Devices

Venture Round in 2020
Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Neuro Kinetics

Funding Round in 2019
Neuro Kinetics, Inc. specializes in eye tracking technology and non-invasive neuro-otologic diagnostic testing tools tailored for audiologists, ENTs, neuro-otologists, neuro-ophthalmologists, and neurologists worldwide. The company’s portfolio includes the I-PORTAL Neuro-Otologic Test Center, a comprehensive system for vestibular and neuro-otologic diagnostics, along with the VEST software for neuro-otologic analysis. Additional products encompass I-Portal Video Nystagmography and I-Portal Video Oculography, which facilitate vestibular diagnostic solutions and eye tracking tests. Neuro Kinetics also supports its clients with maintenance, training, and accessory services. Founded in 1984 and based in Pittsburgh, Pennsylvania, the company aims to enhance the diagnostic capabilities of healthcare professionals and improve patient treatment outcomes. As of September 2019, it operates as a subsidiary of Neurolign Technologies Inc.

Ariel Precision Medicine

Convertible Note in 2017
Ariel Precision Medicine is a healthcare company that creates innovative solutions to simplify the personalized treatment of complex disease. It offers clinical decision support tools for the emergency department and the clinic. The company was founded in 2015 and headquartered in Pennsylvania, United States.

Forest Devices

Convertible Note in 2017
Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Cognition Therapeutics

Venture Round in 2013
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, dedicated to developing small-molecule therapeutics for neurodegenerative and neuro-ophthalmic disorders. Established in 2007, the company focuses on addressing the underlying cellular damage caused by toxic proteins associated with diseases such as Alzheimer's and dry age-related macular degeneration. Its lead product candidate, CT1812, is an oral drug designed to penetrate the blood-brain barrier and selectively target the S2R complex, aiming to restore normal cellular processes disrupted by these conditions. Cognition Therapeutics combines biological expertise with proprietary assays and medicinal chemistry to create innovative and effective drug candidates for age-related degenerative diseases affecting the central nervous system and retina.

ALung

Series B in 2013
ALung Technologies is a medical device manufacturing company based in Pittsburgh, Pennsylvania, founded in 1997. The company specializes in developing devices for gas exchange to treat acute and chronic respiratory disorders. Its primary product, the Hemolung Respiratory Assist System (RAS), functions as a dialysis-like alternative or supplement to mechanical ventilation, allowing physicians to effectively remove carbon dioxide from the blood without relying solely on the lungs. This technology aims to reduce the need for intubation and invasive ventilation, thereby improving patient outcomes. Additionally, ALung offers the Hattler Catheter, which facilitates the insertion of its gas exchange devices into the central venous bloodstream.

Cognition Therapeutics

Venture Round in 2012
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, dedicated to developing small-molecule therapeutics for neurodegenerative and neuro-ophthalmic disorders. Established in 2007, the company focuses on addressing the underlying cellular damage caused by toxic proteins associated with diseases such as Alzheimer's and dry age-related macular degeneration. Its lead product candidate, CT1812, is an oral drug designed to penetrate the blood-brain barrier and selectively target the S2R complex, aiming to restore normal cellular processes disrupted by these conditions. Cognition Therapeutics combines biological expertise with proprietary assays and medicinal chemistry to create innovative and effective drug candidates for age-related degenerative diseases affecting the central nervous system and retina.

Cognition Therapeutics

Series A in 2011
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, dedicated to developing small-molecule therapeutics for neurodegenerative and neuro-ophthalmic disorders. Established in 2007, the company focuses on addressing the underlying cellular damage caused by toxic proteins associated with diseases such as Alzheimer's and dry age-related macular degeneration. Its lead product candidate, CT1812, is an oral drug designed to penetrate the blood-brain barrier and selectively target the S2R complex, aiming to restore normal cellular processes disrupted by these conditions. Cognition Therapeutics combines biological expertise with proprietary assays and medicinal chemistry to create innovative and effective drug candidates for age-related degenerative diseases affecting the central nervous system and retina.

NeuroInterventional Therapeutics

Seed Round in 2010
NeuroInterventional Therapeutics, Inc. ("NIT", dba Neurointerventions, Inc.) is a Pittsburgh-based company which designs and manufactures advanced catheter systems used to find, trap, and extract thrombus ("blood clots") in a wide range of cerebral vessels, thereby increasing chances of survival and minimizing disability.

Saladax Biomedical

Series C in 2010
Saladax Biomedical, Inc. is a precision medicine company based in Bethlehem, Pennsylvania, specializing in the development and commercialization of diagnostic blood tests designed to enhance personalized medicine. The company focuses on adherence testing for psychiatrists and chemotherapeutic drug monitoring for oncologists. Its product line, known as MyCare, includes tests such as MyCare Psychiatry, which helps determine the appropriate antipsychotic dosage for patients; MyCare Oncology, which optimizes chemotherapy exposure; and MyCare Neurology, for assessing the effects of neurological drugs. Specific tests include My5-FU, MyPaclitaxel, MyDocetaxel, and MyImatinib, which are used to manage treatment for various cancers and conditions. Saladax markets its products through distributors across the Asia Pacific, European Union, Middle East, and North Africa, as well as through direct sales in select regions. With over 15 years of experience, Saladax aims to provide convenient and cost-effective solutions for therapeutic drug monitoring, enabling physicians to tailor drug dosing to individual patient needs.

Cognition Therapeutics

Series A in 2009
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, dedicated to developing small-molecule therapeutics for neurodegenerative and neuro-ophthalmic disorders. Established in 2007, the company focuses on addressing the underlying cellular damage caused by toxic proteins associated with diseases such as Alzheimer's and dry age-related macular degeneration. Its lead product candidate, CT1812, is an oral drug designed to penetrate the blood-brain barrier and selectively target the S2R complex, aiming to restore normal cellular processes disrupted by these conditions. Cognition Therapeutics combines biological expertise with proprietary assays and medicinal chemistry to create innovative and effective drug candidates for age-related degenerative diseases affecting the central nervous system and retina.

Caliber Infosolutions

Seed Round in 2009
Caliber Infosolutions Inc. is Pittsburgh PA based global company, focused on solutions for Quality Management specially in Pharma and other regulated industries. Thier highly successful flagship product CaliberLIMSTM is treated as a great asset by their end users.

Saladax Biomedical

Series A in 2008
Saladax Biomedical, Inc. is a precision medicine company based in Bethlehem, Pennsylvania, specializing in the development and commercialization of diagnostic blood tests designed to enhance personalized medicine. The company focuses on adherence testing for psychiatrists and chemotherapeutic drug monitoring for oncologists. Its product line, known as MyCare, includes tests such as MyCare Psychiatry, which helps determine the appropriate antipsychotic dosage for patients; MyCare Oncology, which optimizes chemotherapy exposure; and MyCare Neurology, for assessing the effects of neurological drugs. Specific tests include My5-FU, MyPaclitaxel, MyDocetaxel, and MyImatinib, which are used to manage treatment for various cancers and conditions. Saladax markets its products through distributors across the Asia Pacific, European Union, Middle East, and North Africa, as well as through direct sales in select regions. With over 15 years of experience, Saladax aims to provide convenient and cost-effective solutions for therapeutic drug monitoring, enabling physicians to tailor drug dosing to individual patient needs.

Lipella Pharmaceuticals

Seed Round in 2008
Lipella Pharmaceuticals Inc. is a clinical-stage biotechnology company based in Pittsburgh, Pennsylvania, specializing in supportive care for cancer survivors who experience hemorrhagic cystitis. Founded in 2005, the company develops innovative products for intravesical therapy, delivering localized treatments directly to the urinary bladder. Its primary product in clinical development is LP-10, a liposomal formulation of tacrolimus aimed at treating hemorrhagic cystitis. Additionally, Lipella focuses on other conditions such as interstitial cystitis, overactive bladder, and superficial bladder cancer, which affect a significant number of patients in the United States. The company also engages in surveillance and imaging for patients with a history of transitional cell carcinoma, alongside offering clinical supplies and research products.

Cognition Therapeutics

Seed Round in 2007
Cognition Therapeutics, Inc. is a clinical-stage neuroscience company based in Pittsburgh, Pennsylvania, dedicated to developing small-molecule therapeutics for neurodegenerative and neuro-ophthalmic disorders. Established in 2007, the company focuses on addressing the underlying cellular damage caused by toxic proteins associated with diseases such as Alzheimer's and dry age-related macular degeneration. Its lead product candidate, CT1812, is an oral drug designed to penetrate the blood-brain barrier and selectively target the S2R complex, aiming to restore normal cellular processes disrupted by these conditions. Cognition Therapeutics combines biological expertise with proprietary assays and medicinal chemistry to create innovative and effective drug candidates for age-related degenerative diseases affecting the central nervous system and retina.

Crystalplex

Seed Round in 2007
Crystalplex provides cutting-edge fluorescent nanoparticle technology to the biomedical research, molecular diagnostic, and pathology markets. The company products provide test results from smaller samples and with reduced time, lower labor costs, and less expensive instrumentation than currently possible. It also provides better results for drug discovery and diagnostic decision making. Crystaplex specializes in the cost-effective manufacturing of the most robust Quantum Dots available for illumination and solar energy applications. The proprietary technology in their SapphireTM QDs provides a stable crystal design, flexible polymer matrix morphology, and meets environmentally responsible yet demanding performance requirements for high-end consumer electronics applications such as LCD TVs, displays, and high-CRI architectural lighting. Crystaplex was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.

Applied Isotope Technologies

Seed Round in 2007
Applied Isotope Technologies, Inc. creates new technologies, measurement tools, products, and services for environmental and biological analyses. It manufactures and sells isotopic spikes, ESIS-keyed software and reagent kits. The company sells a variety of individual products for environmental analysis, including spiked and natural analytical standards, reagents, isotope spikes, matrices, and sample extraction tools. It also provides advice, information, and technical support, as well as isotope dilution mass spectrometry (IDMS)/speciated isotope dilution mass spectrometry (SIDMS) testing products that enable environmental analytical laboratories to implement speciated analyses using IDMS and SIDMS methods. In addition, the company offers reagent kits for speciated analyses of various difficult-to-measure metal toxins, such as chromium and mercury. Applied Isotope Technologies was founded in 2003 and is based in Pittsburgh, Pennsylvania.

Separation Design Group

Seed Round in 2007
Separation Design Group offers miniature oxygen generators operating at faster cycle times, resulting in a more energy-efficient device. The company was founded in 2003 and is based in Waynesburg, Pennsylvania.

Intelomed

Pre Seed Round in 2007
InteloMed, Inc. is a medical device manufacturer focused on enhancing cardiovascular monitoring to improve patient outcomes. Founded in 2005 and based in Warrendale, Pennsylvania, the company offers the CVInsight Patient Monitoring & Informatics System. This system captures and analyzes a patient’s pulse waveform using proprietary algorithms, providing noninvasive, real-time insights into cardiovascular stability. It is utilized in various settings including hospitals, outpatient facilities, and during procedures such as hemodialysis and heart failure management. By delivering actionable health information, InteloMed's technology enables clinicians to make informed decisions regarding diagnosis and treatment planning for at-risk patients, thereby improving overall care pathways.

ChemDAQ

Venture Round in 2007
ChemDAQ, Inc. specializes in manufacturing gas detection systems designed to protect personnel from exposure to toxic sterilant gases. The company offers the ChemDAQ sterilant gas monitoring system and the ChemDAQ data acquisition module, which enables continuous monitoring, display, and documentation of sterilant gas levels. Founded in 1996 and based in Pittsburgh, Pennsylvania, ChemDAQ serves a variety of sectors, including healthcare, medical device manufacturing, and the food and beverage industries. Its systems are aimed at ensuring safety and compliance with industry standards, thereby fostering a safe and productive work environment.

StageMark

Series B in 2007
StageMark develops and markets inflammatory diseases identification and monitoring solutions. The company's product, CB-CAPs, enables user to analyze complement products bound to various blood cell types such as erythrocytes, platelets, reticulocytes, and lymphocytes. StageMark, Inc. was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.

STARR Life Sciences

Venture Round in 2006
STARR Life Sciences Corp. specializes in the development and manufacturing of research equipment for small animal studies, aimed at advancing life sciences. Based in Oakmont, Pennsylvania, the company offers a range of products including the MouseOX Plus pulse oximeter, which measures vital parameters such as heart rate, arterial oxygen saturation, and temperature in mice and rats. Additionally, STARR Life Sciences provides the E-Mitter Telemetry System, enabling continuous monitoring of temperature, activity, and heart rate through implantable telemetry devices and accompanying software. Their product lineup also includes incage running wheels, activity cage systems, and infrared motion sensors, all designed to facilitate non-invasive observation of animal health and behavior. The company's offerings are utilized by researchers, veterinarians, and institutions within the pharmaceutical and academic sectors, reflecting a commitment to supporting medical research through innovative technology.

RedPath Integrated Pathology

Pre Seed Round in 2006
RedPath Integrated Pathology, LLC is a reference laboratory based in Pittsburgh, Pennsylvania, that specializes in oncology diagnostics. Founded in 2004, the company provides support services to pathologists, clinicians, and patients through its innovative PathFinderTG testing platform. This platform is designed for the early and definitive diagnosis of cancer, utilizing genetic analysis to extract objective and quantitative information from small tissue biopsies, cytology samples, and fluid specimens. RedPath's approach aids in resolving diagnostic challenges, particularly in cases where cancer does not respond as expected to treatment.

Immunetrics

Seed Round in 2006
Immunetrics, Inc. is a biosimulation company based in Pittsburgh, Pennsylvania, focused on developing biological models and tools for mechanistic modeling in drug discovery and development. Established in 2003, the company offers a software platform called Aegis, which supports model developers in creating disease-specific models and virtual populations. Immunetrics provides a range of modeling services, including pharmacology modeling that integrates biological pathways to predict clinical outcomes of therapeutic interventions in various medical conditions, particularly acute and chronic inflammatory diseases and autoimmune disorders. Additionally, the company offers consulting services for mechanistic and statistical modeling, as well as data analysis, enabling researchers to better understand and analyze human diseases and syndromes.

Applied Isotope Technologies

Seed Round in 2006
Applied Isotope Technologies, Inc. creates new technologies, measurement tools, products, and services for environmental and biological analyses. It manufactures and sells isotopic spikes, ESIS-keyed software and reagent kits. The company sells a variety of individual products for environmental analysis, including spiked and natural analytical standards, reagents, isotope spikes, matrices, and sample extraction tools. It also provides advice, information, and technical support, as well as isotope dilution mass spectrometry (IDMS)/speciated isotope dilution mass spectrometry (SIDMS) testing products that enable environmental analytical laboratories to implement speciated analyses using IDMS and SIDMS methods. In addition, the company offers reagent kits for speciated analyses of various difficult-to-measure metal toxins, such as chromium and mercury. Applied Isotope Technologies was founded in 2003 and is based in Pittsburgh, Pennsylvania.

Proteopure

Pre Seed Round in 2006
Proteopure offers protein isolation solutions for proteomic results. The company provides a universal method for isolating proteins. Its sample preparation kit uses a protein capture technology, and can specifically separate out proteins from various contaminants, including salts, nucleic acids, and detergents. Proteopure is headquartered in Pittsburgh, Pennsylvania.

StageMark

Venture Round in 2006
StageMark develops and markets inflammatory diseases identification and monitoring solutions. The company's product, CB-CAPs, enables user to analyze complement products bound to various blood cell types such as erythrocytes, platelets, reticulocytes, and lymphocytes. StageMark, Inc. was founded in 2004 and is headquartered in Pittsburgh, Pennsylvania.
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