Venrock

Bright Peak Therapeutics is a biotechnology company focused on developing a range of immunotherapies aimed at treating cancer and autoimmune diseases. The company specializes in creating immuno-cytokines that possess pharmacological properties enabling tissue and cell-specific targeting of cytokine payloads. This innovative approach is designed to enhance the efficacy of treatments, ultimately improving patient outcomes and quality of life. By leveraging its expertise in cytokine therapeutics, Bright Peak aims to advance the field of immunotherapy and provide effective solutions for challenging medical conditions.

Lycia Therapeutics operates as a biotechnology company focused on discovering and developing first-in-class therapeutics using its proprietary Lysosomal Targeting Chimeras (LYTACs) platform. This platform enables the degradation of extracellular and membrane-bound proteins associated with challenging-to-treat diseases like cancer and autoimmune disorders, aiming to provide effective treatments for patients.

Founded in San Francisco in 2016, SmithRx specializes in designing and managing custom pharmacy benefit plans for companies. It leverages a modern technology platform to deliver flexibility, efficiency, and customer satisfaction, aligning incentives through data analytics.

ADARx Pharmaceuticals specializes in the development of RNA editing therapeutics. Founded in 2019, the company focuses on discovering and developing innovative treatments that utilize endogenous enzymes to precisely target and correct single point mutations in mRNA transcripts, restoring the production of functional proteins.

Quiq develops a cloud-based messaging platform that enables businesses to deliver personalized customer support across various channels at scale. Its AI-powered solutions facilitate seamless, proactive communication between brands and consumers via digital messaging channels.

Astronomer is a data engineering software company that builds a managed Apache Airflow platform. Founded in 2014 and based in Cincinnati, Astronomer offers Astro, a data orchestration platform powered by Apache Airflow that enables data teams to build, run, and observe data pipelines-as-code. The platform is designed to deploy, manage, and scale distributed Airflow workflows with features such as isolated resource allocation and controlled user access, supporting data engineers, data scientists, and data analysts in delivering trusted analytics. Astronomer's solutions help organizations increase data availability and visibility by making pipelines observable and governance-friendly across environments.

Suki develops AI-driven voice solutions for healthcare providers. Its primary product, Suki Assistant, uses artificial intelligence and natural language processing to create detailed clinical notes during or after consultations, enabling physicians to complete administrative tasks more efficiently.

Altruist operates a digital investment platform that supports financial advisors in delivering more affordable and accessible independent financial advice. The platform helps advisors serve clients more efficiently by automating research, identifying issues, and streamlining operations, enabling better-informed money decisions. By reducing costs and improving efficiency, Altruist aims to expand access to high-quality financial planning for millions of people while supporting thousands of financial professionals.

Stride Health, Inc. is a health benefits platform that specializes in providing affordable health coverage options for independent workers and part-time employees in the United States. The company offers a range of services, including dental plans, doctor and prescription insurance plans, and various health coverage options tailored to meet the needs of its customers. Stride Health simplifies the enrollment process by guiding users through selecting the most cost-effective health plans, aiming to optimize their tax benefits and enhance their take-home pay. Founded in 2013 and based in San Francisco, California, the company was previously known as Covered, Inc. and rebranded to Stride Health, Inc. in March 2013. Stride Health also provides personal advisory services to assist clients in navigating the complexities of their health insurance options.

Founded in 2005, Interos Inc. specializes in supply chain risk management, offering a platform that aggregates and analyzes large datasets to identify relationships, patterns, and correlations. This enables clients to assess, monitor, and mitigate risks across their extended business ecosystems, including supply chains, partnerships, and alliances.

Element Biosciences develops innovative genetic analysis tools for research and diagnostic markets. Founded in 2017, the company specializes in a disruptive DNA sequencing technology that offers high-quality data, workflow flexibility, and affordable access to next-generation sequencing.

RayzeBio, Inc. is a biotechnology company based in San Diego, California, founded in 2020. The company specializes in developing tumor-targeted small molecule medicines that leverage radioisotopes to improve cancer treatment outcomes. RayzeBio focuses on creating innovative radiopharmaceuticals, particularly utilizing alpha-emitting radioisotopes like Actinium-225, to target solid tumors effectively. With a robust pipeline of drug candidates, RayzeBio is committed to addressing significant market opportunities in oncology through late-stage clinical programs, development initiatives, and discovery efforts. The company's mission is to provide effective therapeutic solutions aimed at defeating cancer.

Astranis develops innovative satellite technology to provide targeted internet access to underserved regions. The company manufactures small satellites for high-orbit deployment, serving diverse sectors such as defense, commercial communications, oil and gas, and telecommunications.

Founded in 2018, Dapper Labs develops blockchain-based platforms that bring non-fungible tokens (NFTs) and innovative digital experiences to fans worldwide. Its flagship product, NBA Top Shot, engages consumers with their favorite brands by creating communities centered around ownership and creativity.

Founded in 2018, Dapper Labs develops blockchain-based platforms that bring non-fungible tokens (NFTs) and innovative digital experiences to fans worldwide. Its flagship product, NBA Top Shot, engages consumers with their favorite brands by creating communities centered around ownership and creativity.

Cyteir Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to developing innovative therapies based on DNA repair biology for cancer treatment and synthetic lethality in autoimmune diseases. Founded in 2012 and headquartered in Lexington, Massachusetts, the company focuses on precision targeting of critical DNA repair factors to induce self-destruction in diseased cells through an overload of DNA damage. Cyteir employs an integrated drug development platform that addresses the imbalance between DNA damage and repair, resulting in a pipeline of small molecule therapeutics aimed at various disease states, including hematological malignancies, solid tumors, and chronic autoimmune disorders. Its lead compound, CYT-0851, is an oral investigational drug designed to inhibit RAD51-mediated homologous recombination, targeting specific vulnerabilities in cancer cells.

Cullinan Therapeutics is a developer of an externally sourced cancer therapeutics intended to end a drug program quickly if the early research suggests it won't work. The company's therapeutics are developed via assets sourced internally through dry lab or externally through business, academic and pharma collaborations, enabling researchers to get a highly diversified portfolio of oncology therapeutics with a unique, cost-efficient business model.

Pharvaris is a clinical-stage biopharmaceutical company focused on developing oral bradykinin B2 receptor antagonists to prevent and treat hereditary angioedema (HAE). Its lead drug candidate, PHA121, is currently in Phase 1 clinical trials.

Olema Oncology is a preclinical biotechnology company dedicated to developing innovative therapies for the treatment and prevention of estrogen receptor-positive breast cancer. The company specializes in discovering and commercializing targeted treatments specifically designed for women's cancers. By leveraging its extensive understanding of endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance, Olema aims to create compounds that surpass existing therapies. The company's focus is on transforming the standard of care for both pre- and post-menopausal women with cancer, with an emphasis on developing more effective and convenient treatment options. Olema's pipeline includes drug candidates such as OP-1250 and OP-3136, which have progressed through discovery and preclinical studies.

Kinnate Biopharma Inc. is a biopharmaceutical company dedicated to the discovery and development of small molecule kinase inhibitors aimed at treating genomically defined cancers. Established in 2018 and headquartered in San Diego, California, the company focuses on precision oncology therapeutics, leveraging its expertise in structure-based drug discovery and translational research. Kinnate's lead product candidate, KIN002787, is a rapidly accelerated fibrosarcoma inhibitor currently in preclinical development for lung cancer, melanoma, and other solid tumors. Additionally, the company is advancing other preclinical candidates, including KIN003, which targets cancer-associated alterations in FGFR2 and FGFR3 genes, and a Cyclin-Dependent Kinase 12 inhibitor in the KIN004 program. Kinnate Biopharma is committed to developing targeted therapeutics for underserved patient populations, aiming to expand the reach of precision medicine in cancer treatment.

Founded in 2017, Devoted Health is dedicated to enhancing the health and well-being of older Americans by offering integrated Medicare Advantage plans. They provide personalized care through a combination of local providers, virtual and in-home care, dedicated guides, and advanced technology.

Lyra Health operates a digital health platform that enhances mental health care for employees by connecting them with a curated network of therapists and coaches. Founded in 2015 and based in Burlingame, California, Lyra uses matching technology to pair individuals with suitable providers based on their needs and preferences. The platform offers live video therapy, coaching, and digital self-care tools, ensuring faster access to care and better outcomes compared to traditional plans. Lyra assesses treatment effectiveness using clinical measures like the PHQ-9 and GAD-7 for conditions such as anxiety and depression. This approach results in significantly more people receiving care and achieving improved mental health outcomes.

Keros Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Lexington, Massachusetts, dedicated to the discovery, development, and commercialization of innovative treatments for hematological and musculoskeletal disorders with significant unmet medical needs. The company's lead product candidate, KER-050, targets low blood cell counts, or cytopenias, including anemia and thrombocytopenia in patients with myelodysplastic syndromes and myelofibrosis. Additionally, Keros is developing KER-047, a small molecule aimed at treating anemia and fibrodysplasia ossificans progressiva, which is currently in Phase 1 clinical trials. Another candidate, KER-012, is being explored for its potential in treating bone loss disorders such as osteoporosis and osteogenesis imperfecta, as well as pulmonary arterial hypertension. Keros Therapeutics emphasizes understanding the role of the Transforming Growth Factor-Beta family of proteins, which are crucial for the regulation of blood cell production and the maintenance of muscle and bone health.

Virta Health is a San Francisco–based health technology company that specializes in treating type 2 diabetes through an online, physician-supported program. The company combines nutritional biochemistry, data science, and digital tools to deliver on-demand care via a continuous remote care platform, providing physicians and health coaches who guide patients to reduce blood sugar and lose weight without medications or surgery. Founded in 2014, Virta offers a treatment approach aimed at reversing type 2 diabetes and improving related metabolic and cardiovascular health.

Encoded Therapeutics is a biotechnology company focused on precision gene therapies to treat a broad range of severe genetic disorders. It develops therapies and a platform that identifies human genome sequences that regulate gene expression using screening and computational approaches. The company's pipeline targets conditions across multiple pathways, including neurocircuitry, liver and metabolic disorders, neurodegeneration, and cardiovascular disease, aiming to help medical practitioners treat patients and improve outcomes. Based in South San Francisco, California, Encoded Therapeutics was founded in 2014 and was previously known as Encoded Genomics.

Inscripta is a gene editing technology company developing scalable digital genome engineering based on CRISPR approaches. It offers MADzymes enzymes for precision editing and is building a benchtop platform comprising an instrument, consumables, software, and assays that enables automated, massively parallel, trackable editing of single cells. The platform aims to lower technical and licensing barriers, delivering push-button workflows and low-cost libraries of thousands of designer proteins, pathways, or genome variants, each with defined and trackable mutations. The company also pursues collaboration by making its MAD7 nuclease available free for research and development to broaden access and accelerate biological discovery.

Sojournix Inc., established in 2016 and headquartered in Waltham, Massachusetts, is a clinical-stage biopharmaceutical company dedicated to developing novel therapies for women's health and neuroendocrine disorders. Its primary focus is SJX-653, a selective neurokinin-3 (NK3) antagonist, designed as a non-hormonal treatment option for moderate to severe vasomotor symptoms associated with menopause.

Inscripta is a gene editing technology company developing scalable digital genome engineering based on CRISPR approaches. It offers MADzymes enzymes for precision editing and is building a benchtop platform comprising an instrument, consumables, software, and assays that enables automated, massively parallel, trackable editing of single cells. The platform aims to lower technical and licensing barriers, delivering push-button workflows and low-cost libraries of thousands of designer proteins, pathways, or genome variants, each with defined and trackable mutations. The company also pursues collaboration by making its MAD7 nuclease available free for research and development to broaden access and accelerate biological discovery.

Orchard Therapeutics is a UK-based biopharmaceutical company dedicated to developing and commercializing innovative gene therapies for rare diseases. Its core focus is autologous ex vivo gene therapy, transforming hematopoietic stem cells into a gene-modified drug product for single-administration treatments. The company's portfolio includes Strimvelis, approved by the EMA in 2016, and several programs in advanced registrational studies across various disease areas.

Amino Apps enables people to discover, develop, and express their interests and passions. Founded in 2011, Amino Apps offer a network of communities allowing its users explore and obsess over the things they're into.

Metacrine, Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, established in 2014. It specializes in the discovery and development of innovative therapies aimed at treating liver and gastrointestinal diseases. The company is advancing a pipeline of drug candidates, with a primary focus on the farnesoid X receptor (FXR), a key target in managing various liver and GI disorders. Its lead candidates, MET409 and MET642, are currently in clinical trials to evaluate their efficacy in treating non-alcoholic steatohepatitis. Additionally, Metacrine collaborates with Novo Nordisk A/S to explore further research opportunities related to fibroblast growth factor 1. The company is committed to developing best-in-class therapies to improve patient outcomes in these challenging medical areas.

Doctor On Demand, Inc. is a telemedicine company that provides an online platform for patients to consult with licensed healthcare providers, including doctors and psychologists, through video calls. Established in 2012 and headquartered in San Francisco, California, the company offers a range of medical services addressing conditions such as cold and flu, allergies, anxiety, and chronic illnesses. Its platform, Synapse, caters to health plans and employers, facilitating both on-demand and scheduled visits via smartphones, tablets, or computers. Doctor On Demand emphasizes accessibility and quality care, enabling patients to easily receive medical attention and prescriptions when needed. Additionally, the company has offices in Minneapolis, Minnesota, and Washington, D.C.

RefleXion Medical Inc. is a medical equipment company based in Hayward, California, focused on revolutionizing cancer treatment through its biologically-guided radiotherapy system (BgRT). This innovative technology allows tumors to continuously signal their location during treatment, enabling the simultaneous targeting of multiple tumors, even in cases of metastasized cancer. The RefleXion X1 machine is cleared for various forms of radiotherapy, including stereotactic body radiotherapy, stereotactic radiosurgery, and intensity-modulated radiotherapy. The BgRT system utilizes positron-emission tomography (PET) imaging data to synchronize tumor location information with the linear accelerator, allowing for real-time adjustments in treatment delivery with subsecond latency. RefleXion Medical has established strategic collaborations with Telix Pharmaceuticals Limited and HealthMyne Inc. since its incorporation in 2009.

Unity Biotechnology is a biotechnology company dedicated to developing therapeutics that prevent, halt, or reverse age-related diseases. Its primary focus involves targeting senescent cells, designing senolytic medicines to clear these cells from the body while leaving normal cells unaffected. The company's pipeline includes UBX1325 for age-related eye diseases like diabetic macular edema.

Inscripta is a gene editing technology company developing scalable digital genome engineering based on CRISPR approaches. It offers MADzymes enzymes for precision editing and is building a benchtop platform comprising an instrument, consumables, software, and assays that enables automated, massively parallel, trackable editing of single cells. The platform aims to lower technical and licensing barriers, delivering push-button workflows and low-cost libraries of thousands of designer proteins, pathways, or genome variants, each with defined and trackable mutations. The company also pursues collaboration by making its MAD7 nuclease available free for research and development to broaden access and accelerate biological discovery.

Kiniksa Pharmaceuticals, Ltd. is a clinical-stage biopharmaceutical company dedicated to discovering, acquiring, developing, and commercializing therapeutic medicines for patients with debilitating diseases that have significant unmet medical needs. The company has a diverse pipeline of clinical-stage product candidates, including Rilonacept, which is undergoing Phase III trials for recurrent pericarditis; Mavrilimumab, a monoclonal antibody in Phase II trials for giant cell arteritis; and KPL-716, currently in Phase 2a trials for prurigo nodularis and Phase 1a trials for atopic dermatitis. Kiniksa also has preclinical candidates, such as KPL-404, which targets the CD40/CD40L interaction in immune responses. Additionally, the company is collaborating with Kite Pharma to explore the combination of Yescarta and Mavrilimumab in patients with relapsed or refractory Large B-Cell lymphoma. Founded in 2015 and headquartered in Hamilton, Bermuda, Kiniksa Pharmaceuticals aims to address multiple autoimmune and autoinflammatory conditions through its innovative approaches.

Aledade is a health technology and services platform that partners with independent primary care physicians to form and operate Accountable Care Organizations in the United States. It provides data analytics, guided workflows, regulatory and contracting support, payer relationships, and local on-the-ground expertise to help practices transform operations, optimize care delivery, and align incentives around value-based care. The platform integrates care data across the continuum, offers practice management tools, and supports governance and policy guidance to enable autonomous physician groups—from small practices to multispecialty networks and community health centers—to improve patient outcomes while reducing overall costs. Headquartered in Bethesda, Maryland, the company was founded in 2014.

Evident.io, Inc. is a security management company based in Pleasanton, California, that specializes in cloud infrastructure security. Founded in 2013, the company provides a software platform designed to enhance security and compliance in public cloud environments, particularly for Amazon Web Services. Its agentless and API-centric Evident Security Platform continuously monitors cloud resources, identifying security misconfigurations, vulnerabilities, and compliance risks. By delivering actionable intelligence in a user-friendly format, Evident.io enables organizations of all sizes to effectively manage their security posture and swiftly remediate identified risks. The company's focus on making cloud security accessible and efficient caters to the needs of DevOps professionals, cloud engineers, and IT risk managers, thus bridging the gap between agile development and robust security practices. In 2018, Evident.io was acquired by Palo Alto Networks, further expanding its capabilities within the cybersecurity landscape.

Salsify is an e-commerce software startup based in Boston, Massachusetts, founded in 2012 by Jason Purcell, Jeremy Redburn, and Rob Gonzalez. The company provides a comprehensive platform known as Commerce Experience Management (CommerceXM), which integrates Product Experience Management tools—including Product Information Management (PIM), Digital Asset Management (DAM), and an Experience Builder—with essential commerce functionalities. This platform is designed to facilitate sales across various channels, including retailers, distributors, marketplaces, social commerce, and direct-to-consumer (D2C) sites. By offering these tools, Salsify aims to enhance brand visibility and performance on digital shelves, helping businesses optimize their product presentation and inventory management to drive online sales effectively.

ShockWave Medical is a medical device company focused on developing and commercializing intravascular lithotripsy technology to treat calcified plaque in peripheral vascular, coronary vascular, and valvular diseases. The company markets lithoplasty catheters, including M5 for above-the-knee peripheral artery disease, C2 for coronary artery disease, and S4 for below-the-knee lesions, designed to modify calcium and improve vessel compliance before angioplasty or stent delivery. Its sonic pressure wave technology aims to limit injury to healthy tissue and facilitate procedures such as transcatheter coronary interventions and valve therapies. The business serves interventional cardiologists, vascular surgeons, and interventional radiologists through a direct sales force and distributors. It operates in the United States, Germany, the rest of Europe, and other international markets. Founded in 2009, ShockWave Medical is headquartered in Santa Clara, California.

Jiff, Inc. is a technology company that specializes in providing a HIPAA-compliant platform for the healthcare industry, enabling the creation of personalized and private communities of care. Founded in 2010 and headquartered in Mountain View, California, Jiff focuses on enhancing communication between healthcare professionals and patients through innovative tools. One of its notable products is JiffPad, an educational platform for iPads that transforms doctor-patient conversations and images into videos, facilitating easier sharing and understanding within the privacy of patients' homes. The company also offers solutions that engage employees by linking company benefits and incentives to healthy behaviors, leveraging familiar wearables and applications. Jiff has formed strategic alliances with firms such as Towers Watson & Co. and Mercer, furthering its mission to improve healthcare delivery and employee engagement. As of April 2017, Jiff operates as a subsidiary of Castlight Health, Inc.

Hua Medicine is a clinical-stage drug development company in China focused on therapies for diabetes and CNS disorders. It develops Dorzagliatin (also known as HMS5552), an oral, first-in-class glucokinase activator for type 2 diabetes, and has advanced Dorzagliatin into NDA-enabling work and Phase III trials in China, including studies in drug-naive and metformin-treated patients. The company is pursuing Dorzagliatin in combination with metformin and in combination with DPP-4 inhibitors, SGLT-2 inhibitors, and insulin in various development stages. In addition, Hua Medicine is developing mGluR5 candidates for Parkinson's disease and related levodopa-induced dyskinesia. The company was founded in 2011 and is headquartered in Shanghai, China.

Spirox, Inc. is a medical device company based in Menlo Park, California, that specializes in improving the quality of life for patients experiencing nasal obstruction due to nasal valve collapse (NVC). Founded in 2011 and formerly known as Nasoform LLC, Spirox has developed the LATERA absorbable nasal implant, which offers a minimally invasive solution for treating one of the most prevalent yet often overlooked causes of nasal obstruction. The LATERA implant is designed to address weakened lateral wall cartilage, providing ENT specialists and facial plastic surgeons with an effective option to alleviate nasal airway obstruction. As of 2017, Spirox operates as a subsidiary of Entellus Medical, Inc.

10x Genomics develops and sells instruments, consumables, and software for analyzing biological systems. Its products include Chromium platforms for single-cell gene expression analysis, immune profiling, epigenetics study, and spatial gene expression measurement. Serving academic, government, biopharmaceutical, and other institutions globally.

VeloCloud Networks is a cloud-delivered software-defined wide-area networking provider that simplifies branch WAN networking by automating deployment and improving performance across private, broadband Internet, and LTE links for distributed enterprises. Its SD-WAN solution combines a cloud-based control plane with enterprise-grade branch and data center appliances and software-defined automation to enable centralized configuration and real-time monitoring. The platform delivers secure, optimized paths to cloud services, private data centers, and enterprise applications, enabling policy-based access for multiple locations. By routing traffic through the cloud network and supporting orchestration of data flows, VeloCloud aims to deliver scalable, flexible connectivity that supports application growth and simplifies branch and end-point implementations.

Audentes Therapeutics, a clinical stage biotechnology company based in San Francisco, specializes in developing gene therapy products aimed at treating serious, life-threatening rare diseases resulting from single gene defects. The company is advancing several therapeutic candidates, including AT132 for X-linked myotubular myopathy, AT342 for Crigler-Najjar syndrome, and AT845, which is in preclinical studies for Pompe disease. Additionally, Audentes is developing vectorized antisense treatments for Duchenne muscular dystrophy and myotonic dystrophy type 1. It has established collaborative agreements with Genethon and the University of Pennsylvania to further research and commercialization efforts for these therapies. Founded in 2012, Audentes Therapeutics was acquired by Astellas Pharma in January 2020 and operates under the name Astellas Gene Therapies, focusing on gene therapy research, development, and future commercialization.

Kyruus, Inc. is a Boston-based company that develops web-based software solutions aimed at optimizing physician networks for hospitals, health systems, and life science companies. Founded in 2010, Kyruus offers a suite of analytically driven products designed to enhance provider search and scheduling, ensuring that patients are matched with the most suitable healthcare providers. Key offerings include Kyruus Passport, which allows physicians to track their activity and productivity, and Kyruus Profiles, which enables administrators to analyze physician performance metrics. Additionally, the company provides Kyruus MDSeekyr, a platform for identifying high-value providers, and Kyruus Insight Reports, which help executives evaluate network activity and performance trends. By leveraging a proprietary provider data management platform, Kyruus enhances patient engagement and aligns provider supply with patient demand, ultimately improving the overall healthcare experience. Kyruus also maintains offices in San Francisco and New York.

Dynamic Signal, established in 2010 and headquartered in San Bruno, California, specializes in employee communication and engagement. Its platform connects companies with their employees, facilitating the dissemination of timely, relevant content across various channels and devices. This enhances productivity, fosters employee engagement, and amplifies corporate messaging. Dynamic Signal serves hundreds of global enterprises, including 85 Fortune 500 companies, such as IBM, Salesforce, and Edelman.

Included Health is a healthcare company that provides a blend of virtual care, navigation, and community-based healthcare services to enhance the member experience. It combines advanced technology and a compassionate approach to deliver personalized care guidance and advocacy, ensuring that individuals receive the right care at the right time. The company's offerings include access to both virtual and in-person services for a range of healthcare needs, including urgent and primary care, behavioral health, and specialty care. By focusing on a member-centric model, Included Health aims to raise the standard of healthcare for everyone, making it simpler and more effective for individuals to navigate their health journey.

Jiff, Inc. is a technology company that specializes in providing a HIPAA-compliant platform for the healthcare industry, enabling the creation of personalized and private communities of care. Founded in 2010 and headquartered in Mountain View, California, Jiff focuses on enhancing communication between healthcare professionals and patients through innovative tools. One of its notable products is JiffPad, an educational platform for iPads that transforms doctor-patient conversations and images into videos, facilitating easier sharing and understanding within the privacy of patients' homes. The company also offers solutions that engage employees by linking company benefits and incentives to healthy behaviors, leveraging familiar wearables and applications. Jiff has formed strategic alliances with firms such as Towers Watson & Co. and Mercer, furthering its mission to improve healthcare delivery and employee engagement. As of April 2017, Jiff operates as a subsidiary of Castlight Health, Inc.

Edge Therapeutics is a clinical-stage biotechnology company based in Berkeley Heights, New Jersey, focused on developing innovative therapies for acute, life-threatening neurological conditions. Established in 2009, the company aims to transform treatment paradigms in hospital settings through its proprietary platform, Precisa, which facilitates the creation of polymer-based therapeutics designed for targeted delivery to injury sites. The lead product candidate, EG-1962, is currently undergoing evaluation in the Phase 3 NEWTON 2 study, aimed at improving outcomes for patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). Additionally, Edge is assessing EG-1964 as a potential prophylactic treatment for chronic subdural hematoma, aimed at preventing recurrent bleeding on the brain's surface. Through these efforts, Edge Therapeutics seeks to address serious unmet medical needs in the field of neurology.

RedSeal, Inc. specializes in cybersecurity analytics solutions aimed at enhancing the digital resilience of organizations and government agencies globally. Founded in 2004 and based in San Jose, California, RedSeal's platform creates detailed network models and assesses security risks, allowing users to prioritize actions for remediation. By identifying potential attack paths to critical assets, the solution helps organizations allocate their limited security resources effectively, improve incident response times, and maintain comprehensive network visibility. RedSeal's offerings support compliance with various industry regulations and standards, while its technology integrates seamlessly with leading security tools and infrastructure providers. The company serves a diverse client base, including major financial institutions, retail companies, and U.S. federal agencies. RedSeal has established partnerships with top network infrastructure suppliers and is backed by several notable venture capital firms.

REGENXBIO is a clinical-stage biotechnology company developing gene therapy product candidates using its proprietary NAV Technology Platform. This platform delivers genes to cells to address genetic defects or produce therapeutic proteins. REGENXBIO's pipeline includes RGX-314 for wet age-related macular degeneration, RGX-121 and RGX-111 for mucopolysaccharidoses, RGX-181 for late infantile neuronal ceroid lipofuscinosis type II disease, and RGX-501 for homozygous familial hypercholesterolemia. The company also licenses its platform to other biopharmaceutical companies.

Dollar Shave Club is a lifestyle brand and e-commerce company that develops and sells grooming products for men. It uses an exclusive R&D process that includes botanicals and chemists to create its own products at affordable prices. Founded in 2012 and based in Santa Monica, California, the company offers razors, blades, shave butter, aftershave liquids, face washes, wipes, and gift cards, primarily through a subscription model that provides convenient access to products at reasonable prices.

Dstillery is a digital advertising technology company that develops a digital intelligence platform for brands and media partners. The platform enables brand-specific and cross-channel marketing across mobile, desktop, and video by integrating mobile location insights with desktop behaviors to optimize campaigns. It includes Dscover Maps, a geospatial insights tool that analyzes market composition by geography or location, and uses artificial intelligence to derive customer insights for audience targeting. The company emphasizes privacy-friendly options such as ID-free behavioral targeting and offers Custom AI Audiences for brand-specific targeting, supporting programmatic advertising for brands and agencies in the United States.

CTERA Networks Ltd., established in 2008, specializes in providing a private cloud storage service platform that centrally manages security and governance for organizations. Its core product, the CTERA Enterprise File Services Platform, enables IT departments to deliver secure file services from any cloud, serving diverse industries such as financial services, healthcare, and government. The platform modernizes storage, backup, and file collaboration across dispersed enterprises, ensuring data protection, GDPR compliance, and swift ransomware recovery. CTERA partners with tech giants like IBM, AWS, and Cisco, and has a global presence with offices in multiple countries.

Coherus Biosciences is a biopharmaceutical company focused on developing, manufacturing, and commercializing biologic therapeutics for oncology and inflammatory diseases. Its pipeline includes biosimilars for immunology, ophthalmology, and oncology.

Shape Security, Inc. is a cybersecurity company specializing in protecting web and mobile applications from automated cyber-attacks. Founded in 2011 and headquartered in Santa Clara, California, with additional offices in Sydney and London, the company utilizes AI-powered defenses to mitigate fraud, abuse, and attacks on applications and APIs. Its key products include ShapeShifter Elements, which enforces real-time security measures, and Shape Protection Manager, a cloud-based management tool for its services. Shape Security has successfully deflected over $1 billion in fraud losses across various sectors, including retail, finance, travel, healthcare, and government, safeguarding organizations from reputational damage and financial losses.

Cloudflare, Inc. is a San Francisco-based software company that specializes in web performance and security services for businesses globally. It operates a cloud platform that integrates various network services, including security solutions such as Cloud Firewall, Bot Management, and Distributed Denial of Service protection. The company enhances website performance through its Content Delivery Network (CDN) and intelligent routing, while also providing optimization tools for content and images. Furthermore, Cloudflare offers reliability solutions like Load Balancing and DNS services, alongside security features aimed at protecting internal resources through Zero Trust Security and Secure Web Gateway. Its consumer offerings include a DNS resolver and a virtual private network (VPN) designed to secure mobile traffic. Cloudflare serves diverse industries, including technology, healthcare, financial services, and government, and was founded in 2009.

Phononic designs and manufactures solid-state cooling and heating solutions. Its products include thermoelectric devices and heat pumps used in electronics cooling, refrigeration, and climate control applications. Founded in 2008, the company is headquartered in Durham, North Carolina.

Smartling is a language service and technology provider that specializes in content localization across various devices and platforms. Established in 2009 by Jack Welde and Andrey Akselrod, the company is headquartered in New York, New York. Smartling offers a Translation Management Platform that empowers brands to expand into new markets and enhance customer engagement. Its cloud-based enterprise translation software facilitates the translation and deployment of multilingual websites, mobile applications, and business documents, enabling organizations to create native experiences for their audiences. Notable clients include British Airways, Uber, and Spotify, which utilize Smartling's solutions to strengthen their global presence and improve their international operations.

Dataminr is a technology company that leverages artificial intelligence to monitor public information sources. It specializes in detecting and alerting clients to high-impact events and emerging risks in real-time, enabling them to make informed decisions across various sectors including finance, security, crisis management, and news.

Personal Capital Corporation is a digital wealth management company that offers financial advisory services and innovative software solutions to help individuals manage their finances effectively. Founded in 2009 and headquartered in Redwood Shores, California, the company provides tools that allow users to monitor income, spending, and investment performance in one place. Its services include wealth management, personalized financial planning, risk assessments, and investment checkup tools. With a user base exceeding 2.5 million customers, Personal Capital combines advanced technology with expert guidance from registered investment advisors to deliver customized financial strategies aligned with clients' goals. Originally known as SafeCorp Financial Corp., the company rebranded to Personal Capital in June 2010, reflecting its commitment to enhancing personal financial management through technology.

Nest Labs is a company specializing in home automation products, particularly known for its innovative, programmable, self-learning thermostats and security systems. The Nest Learning Thermostat, launched in 2011, was the company's flagship product, designed to reduce energy consumption by learning user preferences and adjusting temperatures accordingly. Following this success, Nest Labs introduced the Nest Protect in October 2013, a smoke and carbon monoxide detector. The company further expanded its product line with the introduction of the Nest Cam in June 2015, after acquiring Dropcam. Nest Labs focuses on enhancing home safety and efficiency through technology, providing users with convenience while promoting energy savings.

SmartBiz, Inc., also known as SmartBiz Loans, operates an online lending platform that simplifies the application and processing of small business loans, particularly focusing on SBA loans. Founded in 2008 and headquartered in San Francisco, the company leverages advanced technology to efficiently match borrowers with banks that are most likely to approve their loan requests. The platform automates various stages of the loan process, including application management, document capture, and underwriting, significantly improving processing efficiency for partner banks. SmartBiz aims to enhance access to low-cost funding for small businesses, with a high percentage of referrals leading to successful loan funding. The company serves diverse sectors such as commercial real estate, debt refinancing, and working capital, and is a subsidiary of Better Finance, Inc.

Intarcia Therapeutics, Inc. is a biopharmaceutical company focused on developing therapies for chronic conditions requiring long-term treatment. The company is known for its innovative drug delivery platform, DUROS, which stabilizes and administers therapeutic proteins and peptides effectively. Among its key products is ITCA 650, currently in phase 3 clinical trials for type 2 diabetes, designed to provide patients with continuous dosing of an incretin mimetic therapy. Intarcia also explores treatments for obesity and other chronic disorders. Established in 1995 and headquartered in Boston, Massachusetts, Intarcia operates a manufacturing facility in Hayward, California, and a research and development center in Durham, North Carolina. The company was previously known as BioMedicines, Inc. before adopting its current name in 2004.

Sapphire Energy, Inc. is a pioneering company based in San Diego, California, that focuses on producing renewable solutions from algae. Founded in 2007, the company utilizes sunlight, carbon dioxide, non-potable water, and non-arable land to cultivate algae in outdoor ponds, which generates biomass that can be transformed into high-value products, including oils, aquaculture and animal feeds, and renewable fuels. Sapphire Energy is unique in its approach, as its processes rely solely on photosynthetic microorganisms, distinguishing them from traditional biofuels that often depend on food crops. The company's products are designed to enhance and replace petroleum-based materials while being compatible with existing infrastructure. Sapphire operates a research and development facility in Las Cruces, New Mexico, and is developing an Integrated Algal BioRefinery in Columbus, New Mexico, with the aim of advancing the renewable energy landscape and contributing to a more sustainable planet.

Ariosa Diagnostics specializes in non-invasive prenatal screening tests. Its Harmony Prenatal Test is widely used and offers accurate risk assessment for common fetal chromosome conditions, reducing the need for invasive procedures like amniocentesis.

Klout is an application that assesses social influence by analyzing a user's ability to drive engagement across various social media platforms. By connecting their social network accounts, users receive a score ranging from 1 to 100, which reflects their capacity to inspire actions within their online communities. This scoring system helps individuals gain insights into their influence and understand how they impact others. Additionally, Klout offers opportunities for users to cultivate and be acknowledged for their social influence, fostering a deeper connection between personal engagement and recognition in the digital landscape.

PowerVision, Inc. is a medical device company based in Belmont, California, focused on developing advanced intraocular lenses (IOLs) designed to restore vision for individuals affected by presbyopia and cataracts. Established in 2002, the company has created the FluidVision accommodating intraocular lens technology, which simulates the natural function of a healthy eye. This innovative lens utilizes a small amount of fluid to adjust its shape dynamically, allowing for clear vision at various distances. PowerVision aims to address the vision challenges faced by millions, particularly the over 20 million individuals in the U.S. with cataracts and the more than 90 million affected by presbyopia. The FluidVision lens represents a significant advancement in vision correction, potentially freeing patients from the need for glasses or other vision correction methods. In 2019, PowerVision was acquired by Alcon Laboratories, Inc.

Aria Systems provides a cloud-based platform for managing recurring revenues. It offers Aria, an enterprise-grade solution for subscription-based billing, serving clients across hi-tech, media, telecom, and finance industries worldwide.

Lavante, Inc. is a provider of cloud-based supplier information management (SIM) and audit recovery solutions, primarily serving Fortune 1000 companies across various industries, including hospitality, retail, entertainment, manufacturing, and medical. Founded in 2001 and based in San Jose, California, Lavante offers several key products: Lavante SIM, which automates the management and validation of supplier profiles; Lavante Recovery, an on-demand solution for recovery auditing; and Lavante Connect, a platform that connects companies with their suppliers. These tools are designed to reduce the costs associated with onboarding and managing suppliers, facilitate compliance with government regulations, and ensure the rapid recovery of available open credits. Lavante, formerly known as AuditSolutions Inc., became a subsidiary of PRGX USA, Inc. in 2016.

Cerulean Pharma Inc. is a privately-held biopharmaceutical company specializing in the development of innovative nanotechnology-based therapeutics, primarily targeting oncology, cardiovascular, autoimmune, and inflammatory diseases. The company focuses on creating nanoparticle-drug conjugates that aim to selectively target tumors, minimize toxicity, and facilitate drug combinations. Among its notable products is Ovaprene, a contraceptive designed to offer multiple weeks of protection without hormones, addressing needs in fertility and vaginal health. Cerulean Pharma boasts a distinguished management team and advisory board, comprising experts with extensive experience in product development and scientific advancements from leading organizations and institutions, including GlaxoSmithKline, Merck, and Harvard Medical School.

Pathwork Diagnostics, located in Redwood City, California, specializes in the development of molecular diagnostics for oncology. The company is known for its Pathwork Tissue of Origin Test, which was the first microarray-based gene expression test to receive FDA clearance. This innovative test assists in the identification of challenging tumors, including poorly differentiated, undifferentiated, and metastatic cancers. Pathwork Diagnostics offers lab services for various specimen types, including formalin-fixed, paraffin-embedded, and frozen samples, leveraging genomic information to enhance tumor classification and support oncological decision-making.

AppNexus is a cloud-based advertising technology platform that enables and optimizes programmatic online advertising for buyers and sellers of digital inventory. The platform supports real-time bidding, trading desks, and marketplaces to maximize yield and campaign performance, and provides a digital delivery system and the AppNexus Publisher Suite for ad serving, planning, forecasting, diverse marketplace sales, and direct campaign management. It also offers PriceCheck, a header bidding solution for banner, video, and interstitial units, and AppNexus Apps, an application platform for third-party vendors to develop features for clients and reach new audiences.

Retail Solutions Inc. specializes in cloud-based data transformation software tailored for consumer packaged goods (CPG) manufacturers and retailers. Founded in 2003 and headquartered in San Jose, California, the company, formerly known as The Tag Tracking Company, Inc., rebranded in December 2007. Retail Solutions provides a comprehensive suite of Software-as-a-Service (SaaS) solutions designed to enhance business intelligence, on-shelf availability, and demand signal management for its clients. Its offerings include analytics for shopper marketing, reporting tools, and support for omnichannel success. The platform is utilized by over 500 manufacturers and 225 retailers, including notable names in the grocery, drug, and mass retail sectors. Retail Solutions aims to maximize return on investment through actionable insights derived from consumer demand data, enabling clients to optimize product availability, pricing, and promotions while improving overall operational efficiency and consumer satisfaction. As of October 2020, Retail Solutions operates as a subsidiary of Information Resources, Inc.

Gazelle is an e-commerce platform focused on the buying and selling of used electronic devices, including smartphones, tablets, laptops, and desktops. Founded in 2006 and headquartered in Boston, Massachusetts, with operations in Louisville, Kentucky, the company offers consumers an easy way to acquire cost-effective electronic gadgets. Gazelle pays cash for pre-owned devices, which it inspects and certifies before reselling them to customers. This process not only provides a convenient option for consumers looking to stay connected but also promotes the recycling of electronic gadgets, contributing to sustainability in the technology sector.

Castlight Health is dedicated to simplifying the healthcare experience and promoting healthier, more productive lives. Its health navigation platform integrates with various health vendors, benefits resources, and plan designs, creating a comprehensive application that addresses diverse health needs. By tailoring guidance to individual profiles, Castlight assists users, whether they are healthy, managing chronic conditions, or seeking medical care, in accessing optimal resources. The company aims to help organizations manage rising healthcare costs and enhance the value of their benefits investments. Since its inception, Castlight has introduced innovative solutions such as data-driven price transparency tools and a consumer-friendly wellbeing platform. Currently, it serves millions of users and partners with numerous large employers, positioning itself as a key player in the healthcare sector. Castlight is headquartered in San Francisco.

Achaogen, Inc. is a biopharmaceutical company based in South San Francisco, California, that specializes in the development and commercialization of antibacterial agents targeting multi-drug resistant (MDR) gram-negative infections. The company's primary focus is on plazomicin, which is intended for treating serious bacterial infections caused by MDR enterobacteriaceae, including carbapenem-resistant strains. Additionally, Achaogen is developing C-Scape, an orally-administered combination of clavulanate and ceftibuten aimed at addressing serious infections linked to expanded spectrum beta-lactamases producing enterobacteriaceae. Achaogen has established collaborations with various organizations, including Thermo Fisher Scientific and Ionis Pharmaceuticals, to support its drug development efforts. The company was incorporated in 2002, but faced financial difficulties, leading to a Chapter 11 bankruptcy filing in 2019, which culminated in a liquidation plan approved in 2020. All of Achaogen's revenue has been derived from government contracts for research and development within the United States.

Celladon Corporation, established in 2000 and headquartered in La Jolla, California, is a biotechnology company focused on developing molecular therapies for treating heart failure. The company's primary product candidate is MYDICAR, an enzyme replacement therapy aimed at addressing the key enzyme deficiency in advanced heart failure. This therapy targets SERCA2a, an enzyme crucial for regulating calcium cycling and contractility in heart muscle cells.

RedSeal, Inc. specializes in cybersecurity analytics solutions aimed at enhancing the digital resilience of organizations and government agencies globally. Founded in 2004 and based in San Jose, California, RedSeal's platform creates detailed network models and assesses security risks, allowing users to prioritize actions for remediation. By identifying potential attack paths to critical assets, the solution helps organizations allocate their limited security resources effectively, improve incident response times, and maintain comprehensive network visibility. RedSeal's offerings support compliance with various industry regulations and standards, while its technology integrates seamlessly with leading security tools and infrastructure providers. The company serves a diverse client base, including major financial institutions, retail companies, and U.S. federal agencies. RedSeal has established partnerships with top network infrastructure suppliers and is backed by several notable venture capital firms.

Alimera Sciences, Inc. is a pharmaceutical company focused on the research, development, and commercialization of prescription ophthalmic pharmaceuticals, particularly targeting diseases affecting the retina. The company is best known for its product ILUVIEN, an intravitreal implant designed for the treatment of diabetic macular edema (DME), a serious condition that can lead to vision loss in individuals with diabetes. ILUVIEN is administered through a non-surgical procedure, delivering a continuous microdose of fluocinolone acetonide directly to the eye, thereby reducing the need for frequent injections. Alimera Sciences also collaborates with EyePoint Pharmaceuticals for the development of additional corticosteroid delivery technologies aimed at treating various eye conditions. The company markets its products through direct sales and distribution channels, serving physician offices, pharmacies, and hospitals. Founded in 2003, Alimera Sciences is headquartered in Alpharetta, Georgia, and operates internationally, including in markets such as Germany, the United Kingdom, China, and the Middle East.

BlogHer is a community and media company that supports women who blog by providing exposure, education, and economic empowerment. It operates a cross-platform media network that publishes and curates news, information, advice, and research on women in social media across topics such as food, fashion, health, work and life, and parenting. The company hosts conferences and runs a publishing network comprising a large group of blogs, offering women creators opportunities to reach audiences, share voices, and develop their businesses. Based in California, BlogHer focuses on connecting women online and in person through content platforms, events, and a network of contributors.

Transonic Combustion, founded in 2006 and headquartered in Camarillo, California, specializes in advanced fuel injection systems designed to enhance the efficiency of modern automotive engines. The company's TSCi™ fuel delivery technology is tailored for global automotive manufacturers, aiming to improve fuel efficiency and performance in various engine platforms. Transonic Combustion is backed by notable venture capital firms, including Venrock, Khosla Ventures, Rustic Canyon, and Saints Capital, indicating strong investor confidence in its innovative approach to fuel technology.

Quantenna Communications, Inc. specializes in the design, development, and marketing of advanced high-speed wireless communication solutions that facilitate wireless local area networking. Founded in 2006 and headquartered in San Jose, California, the company offers a diverse portfolio of products, including radio frequency and digital baseband chips that adhere to various IEEE Wi-Fi standards, such as 802.11n, 802.11ac, and draft Wi-Fi 6. Quantenna's offerings also include Qdock, a software framework that integrates third-party applications with its Wi-Fi solutions. The company's products cater to a wide range of applications, including home networking devices, retail, outdoor, small and medium businesses, enterprise, industrial, and consumer electronics. Quantenna sells its Wi-Fi solutions directly to original equipment manufacturers, original design manufacturers, and third-party distributors, with a significant portion of its revenue generated from the Asia-Pacific region. As of 2019, Quantenna operates as a subsidiary of ON Semiconductor Corporation.

Zeltiq Aesthetics, Inc. is a medical technology company founded in 2005 and headquartered in Pleasanton, California. It specializes in the development and commercialization of non-invasive products aimed at the selective reduction of fat. The company's flagship product, the CoolSculpting system, employs a patented method known as Cryolipolysis, which utilizes precisely controlled cooling to target and eliminate stubborn fat cells without damaging surrounding tissue. This FDA-cleared device is designed for various applications in dermatologic treatments and is marketed primarily to dermatologists, plastic surgeons, and aesthetic specialists across North America, the Asia-Pacific, Europe, and Latin America. Zeltiq Aesthetics was formerly known as Juniper Medical, Inc. and rebranded in July 2007. As of 2017, it operates as a subsidiary of Allergan plc.

IP Commerce is a privately held software company serving small and medium sized businesses (SMBs). Its flagship solution, Commerce Sync, simplifies accounting for thousands of SMBs, helping business owners realize valuable time savings, increased accuracy, and complete business visibility. The Company is headquartered in Denver, Colorado.

Tudou Holdings is a prominent Chinese video sharing website that facilitates user engagement and creativity through its platform. Launched in 2005 by Wang Tei, Tudou allows users to watch, upload, rate, share, comment on, and recommend a variety of video content, including user-generated videos, licensed materials, and original programming. This interactive experience empowers young independent video producers to showcase their creativity. In 2012, Tudou merged with Youku, forming Youku Tudou, Inc., which became a leading entity in the online video sector in China. As of 2013, the platform attracted approximately 227 million unique monthly visitors, establishing a significant user base that outperformed major competitors in the industry.

Bungee Labs is the company behind Bungee Connect, a web-based Ajax environment for creating interactive web applications. The goal of the product is to allow developers to "efficiently create and instantly deliver rich web applications for the small-to-medium business market." This is done by providing an online environment where developers and clients don't have to install anything. Bungee Connect also automates SOAP and REST based web services. Once projects are complete, developers can easily deploy their applications on Bungee Connect's grid servers.

Alimera Sciences, Inc. is a pharmaceutical company focused on the research, development, and commercialization of prescription ophthalmic pharmaceuticals, particularly targeting diseases affecting the retina. The company is best known for its product ILUVIEN, an intravitreal implant designed for the treatment of diabetic macular edema (DME), a serious condition that can lead to vision loss in individuals with diabetes. ILUVIEN is administered through a non-surgical procedure, delivering a continuous microdose of fluocinolone acetonide directly to the eye, thereby reducing the need for frequent injections. Alimera Sciences also collaborates with EyePoint Pharmaceuticals for the development of additional corticosteroid delivery technologies aimed at treating various eye conditions. The company markets its products through direct sales and distribution channels, serving physician offices, pharmacies, and hospitals. Founded in 2003, Alimera Sciences is headquartered in Alpharetta, Georgia, and operates internationally, including in markets such as Germany, the United Kingdom, China, and the Middle East.

PEAK Surgical is a medical device company based in Palo Alto, California, specializing in innovative surgical tools designed to enhance precision and control during surgical procedures. The company offers the PEAK Surgery System, which includes a range of disposable cutting devices that combine the accuracy of a scalpel with the bleeding control typically associated with traditional electrosurgery, minimizing collateral damage. This system is approved for use in various surgical specialties, including general, plastic and reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological procedures in the United States, as well as for general surgery in the European Union. PEAK Surgical aims to address critical needs in the surgical market by providing advanced solutions that improve patient outcomes.

Boston Power is a developer of advanced lithium-ion battery technology, focusing on enhancing the quality and safety of energy storage solutions. The company has created the Sonata technology platform, which offers batteries that charge more quickly, have extended lifespans, and provide superior performance compared to existing options in the market. This innovative technology is designed for various applications, including consumer electronic devices such as laptops, PDAs, and mobile phones, as well as electric vehicles and utility energy storage systems. By delivering unmatched capabilities, Boston Power aims to meet the growing demands for efficient and reliable portable power sources.

INRIX is a leading provider of data and analytics focused on intelligent mobility, utilizing big data from connected devices and vehicles to generate insights about how people move globally. Founded in 2005 and headquartered in Kirkland, Washington, INRIX offers an on-demand analytics platform designed for cities and road authorities, enabling data-driven decision-making to enhance mobility efficiency and safety. The company's services extend to financial sectors, providing insights into consumer trends, supply chain health, and economic forecasting. By integrating with various partners across the mobility ecosystem, INRIX supports initiatives such as improving traffic signal timing, optimizing last-mile delivery, and enhancing overall road safety. Through its innovative approach, INRIX plays a crucial role in advancing transportation technology and improving mobility from the first mile to the last.

Mevion Medical Systems, Inc. is a company specializing in the development of proton therapy systems for cancer treatment. Founded in 2004 and headquartered in Littleton, Massachusetts, Mevion has established itself as a leader in the radiation therapy sector by creating innovative and effective solutions that enhance cancer care. The company, formerly known as Still River Systems, transitioned to its current name in 2011. Its flagship product, the MEVION S250 Proton Therapy System, aims to combine the advantages of traditional proton therapy with reduced size, cost, and complexity. This advancement enhances beam reliability and system uptime, making proton therapy more accessible and economically viable for cancer centers worldwide. Mevion operates internationally, with additional offices in the United Kingdom, China, and Japan, serving a global clientele.

Acceleron Pharma is a biopharmaceutical company based in Cambridge, Massachusetts, founded in 2003. It specializes in discovering, developing, and commercializing therapeutics to treat serious and rare diseases. Acceleron's portfolio includes luspatercept-aamt, marketed as REBLOZYL for treating anemia in adult patients with beta-thalassemia, and also under investigation for myelodysplastic syndromes and myelofibrosis. Additionally, the company is developing Sotatercept for pulmonary arterial hypertension and ACE-083 for Charcot-Marie-Tooth disease. Acceleron's research focuses on growth and differentiation factors that regulate cellular proliferation, differentiation, and survival in various tissue types. The company collaborates with other organizations to advance its therapeutic candidates.

Adnexus, a Bristol-Myers Squibb R&D Company, specializes in the discovery and development of Adnectins, a unique class of targeted biologics. These proteins are engineered to block or stimulate therapeutic targets to combat various diseases, addressing significant medical needs in oncology, immunology, and cardiovascular health. Utilizing a proprietary protein engineering system known as PROfusion™, Adnexus can generate a vast library of over 10 trillion potential Adnectins. This technology enhances the efficiency of identifying candidates with desirable therapeutic properties. Among its product candidates is Angiocept/CT-322, an anti-angiogenesis agent aimed at treating cancer by inhibiting the VEGFR-2 pathway. Since its acquisition by Bristol-Myers Squibb in 2007, Adnexus has further advanced its capabilities in developing innovative medicines to improve patient outcomes.

Neoconix, Inc. is a supplier of low-profile, high-performance electrical connectors catering to mobile, enterprise IT, and industrial markets. Founded in 2002 and based in San Jose, California, the company specializes in miniaturized connectors that leverage its patented PCBeam technology. This technology utilizes standard printed circuit lithographic processes, enabling rapid development and competitive pricing for custom electrical connector solutions. Neoconix offers a diverse range of products, including standard mobile and consumer connectors, high-speed connectors, and various custom connector options for applications in computing, telecommunications, consumer electronics, military-aerospace, medical devices, and test equipment. With over 60 patents issued or pending, Neoconix is recognized for delivering some of the industry's lowest profile connectors, achieving high reliability and extreme performance exceeding 25Gb/s. The company was previously known as Epic Technology, Inc. before adopting its current name in December 2004.

PGP Corporation specializes in email and data encryption software solutions tailored for enterprises, businesses, and government agencies. The company's product offerings include the PGP Encryption Platform, which enhances enterprise data protection, and the PGP Universal Server, designed to streamline encryption management across organizations through a centralized administrative console. Additionally, PGP Universal Gateway Email facilitates secure email communications with centrally managed encryption, while PGP Whole Disk Encryption ensures continuous protection of disk data. PGP Endpoint provides integrated security features that detect and secure removable storage devices, and PGP NetShare allows teams to share documents on file servers with automatic and transparent encryption. Overall, PGP Corporation focuses on delivering comprehensive security solutions to safeguard sensitive information.

Founded in 1998, TAE Technologies is dedicated to developing clean fusion energy through advanced particle accelerator and plasma physics. Its mission is to create a sustainable energy source with no harmful byproducts.

ULocate Communications offers its users with wireless location-based services that leverages individual locations for customized deliveries. ULocate Communications is a U.S.-based company that was founded in 2003.