Rev1 Ventures is a venture capital firm based in Columbus, Ohio. Established in 2005, it focuses on seed-stage investments across various sectors including enterprise software, digital health, life sciences, food tech, advanced materials, and alternative energy. With over $100 million under management, Rev1 provides strategic services alongside capital to help startups scale and corporates innovate.

CincyTech is a Cincinnati-based organization that identifies and nurtures early-stage health, technology, and life sciences startups in Southwest Ohio. It provides strategic guidance, capital, and operational support to entrepreneurs and researchers seeking to commercialize technology, and connects them with regional investors and institutions. By supporting university and hospital research commercialization and catalyzing local investment, CincyTech helps turn innovative ideas into growth companies. The organization collaborates with major regional partners such as Cincinnati Children’s Hospital Medical Center, the University of Cincinnati, and the Cincinnati USA Regional Chamber, and leverages a broad network of funders to back seed-stage ventures across information technology, healthcare, software, and other tech sectors in Ohio and the Midwest.

North Coast Ventures, established in 2006, is a Cleveland-based investment firm focused on early-stage technology companies in the United States. It operates as a professionally managed angel fund, comprising four contributed capital funds. The firm's membership consists of prominent Ohio investors, entrepreneurs, and business leaders who actively support and mentor portfolio companies. North Coast Ventures aims to enhance the early-stage funding environment for both entrepreneurs and investors in the Northeast Ohio region.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Founded in 2012, Drive Capital is a venture capital firm headquartered in Columbus, Ohio. It invests in innovative technology, healthcare, and consumer companies across the Midwest region.

Ohio Innovation Fund, established in 2016 and headquartered in Columbus, Ohio, is a venture capital firm focusing on early-stage investments. It partners with visionary founders to support the growth of disruptive companies, primarily in the technology sector. The firm's investment focus spans across medical technology, biopharma, AR/VR, advanced manufacturing, SaaS, AI/ML, cybersecurity, and mobility. Typically investing between $250,000 to $500,000 initially, with follow-on investments up to $1.25 million based on milestones, Ohio Innovation Fund aims to foster innovation and create industries of the future within the United States, with a particular emphasis on Ohio-based startups.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

Mutual Capital Partners, established in 2004, is a private equity firm headquartered in Westlake, Ohio. The company specializes in venture capital investments, focusing on medical device and healthcare IT companies across the United States. It typically leads or co-leads investments, providing not only capital but also strategic guidance and operational support to its portfolio companies. The firm works closely with its network of over 100 investors, leveraging their expertise for due diligence, customer introductions, and ongoing executive counsel.

Ohio TechAngel Fund III operates as an angel investment network focused on supporting early-stage companies in Ohio, particularly in the sectors of information technology, advanced materials, life sciences, healthcare, and other emerging industries. Managed by Rev1 Ventures and Ohio Tech Angels, the fund draws upon a diverse group of over 340 accredited investors, making it one of the largest angel networks in North America. This organization emphasizes the growth of promising C-Corporations based in Ohio, with investments typically ranging from $100,000 to $500,000. The fund's mission is to transform innovative ideas into successful businesses that contribute to economic growth and entrepreneurial wealth in the region. To date, it has invested significantly in numerous companies, fostering job creation and revenue generation, while also maintaining a network of collaborators to enhance the support available to its investees.

Founded in Columbus, Ohio in 2000, NCT Ventures is a venture capital firm focused on supporting seed and early-stage technology companies across the Midwest. They typically invest between $250k to $1 million initially, with potential follow-on investments of up to $5 million as portfolio companies grow. The firm brings over two decades of entrepreneurial experience and offers hands-on operational support to help visionary entrepreneurs succeed.

Refinery Ventures is an early-stage venture capital firm based in Cincinnati, Ohio, founded in 2017. It focuses on investing in information technology, digital health, and human capital technology sectors, with an emphasis on helping post-seed companies bridge the gap to Series A. The firm supports its portfolio through mentorship and strategic guidance, aiming to accelerate growth for technology-enabled startups in healthcare technology systems and software, SaaS, and enterprise software.

Founded in 2015, Valley Growth Ventures is a venture capital firm based in Youngstown, Ohio. It focuses on investing in early-stage companies across various sectors, including software, information technology, healthcare, energy, additive manufacturing, and advanced materials.

Founded in 2017, Tamarind Hill is a venture capital firm based in Dublin, Ohio. It provides entrepreneurial stage capital to SaaS companies focused on B2B markets such as healthcare IT and enterprise IT, primarily investing throughout the Midwestern U.S.

Advantage Capital Partners is a United States‑based venture capital firm that provides growth equity, debt, and mezzanine financing to small and mid‑market companies, with a focus on underserved communities and state and local economic development. The firm invests across sectors including manufacturing, technology, business services, life sciences, and energy, and also supports real estate development projects with equity and debt. It typically makes initial investments ranging roughly from half a million to ten million in companies with modest sales, and may participate in larger follow‑on rounds or co‑invest with other firms. It uses senior debt, mezzanine debt, subordinated loans, and government‑guaranteed lending, and often pursues equity positions through preferred shares or convertible notes. Advantage Capital operates nationwide in the United States, with roots in New Orleans and offices in multiple states, and has backed thousands of jobs and housing projects as part of its mission to expand inclusive economic growth.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Founded in 2023, Fireroad is a venture capital firm based in Cincinnati, Ohio. It specializes in providing growth investments and venture capital to startups, with a focus on the technology industry.

Founded in 2006, Greycroft is a venture capital firm based in New York and Los Angeles. With over $1 billion under management, it focuses on early-stage investments in consumer internet, financial technology, healthcare, and enterprise software sectors across the United States. The firm leverages its extensive network of media and technology industry connections to help entrepreneurs gain visibility, build strategic relationships, and bring products to market.

Draper Triangle is a venture capital firm founded in 1999, specializing in early-stage investments. Based in Pittsburgh, Pennsylvania, with additional offices in Midwest states, the firm focuses on technology companies, particularly in software, digital media, robotics, and medical devices. Draper Triangle seeks to invest between $250,000 and $2 million initially, aiming for companies with high growth potential.

LOUD Capital is a venture capital and alternative investment firm founded in 2015 by Darshan Vyas and Navin Goyal. Based in Ohio, the firm provides capital, education, and advisory services to help grow impactful companies.

Tiger Global Management is a New York based investment firm that manages public and private market strategies to pursue technology-driven growth opportunities worldwide. Founded in 2001 by Charles (Chase) Coleman, the firm invests in leading global companies across various industries, with a particular emphasis on technology-enabled growth. In public markets it employs long/short and growth strategies, while in private markets it targets opportunities from early to late stage. The firm operates globally, including the United States, China, India, Latin America, and Eastern Europe, and works with portfolio companies across their lifecycle to drive long-term value.

LaunchHouse is a venture capital firm and business accelerator that invests in early-stage technology startups, with a focus on data, SaaS, healthcare software, and other innovative sectors. It provides not only capital, typically investing $0.03 million, but also incubator services and access to a curated community of founders, engineers, and investors. This community offers coliving residencies, executive coaching, fundraising support, and digital courses, fostering learning, professional development, and authentic relationships. LaunchHouse operates in major cities like Los Angeles and New York, as well as in the metaverse, with a mission to create a hub for entrepreneurial innovation and transform ideas into successful companies.

Meritech Capital Partners is a Palo Alto-based venture capital firm founded in 1999 that provides late-stage and growth-stage funding to technology companies in North America. It concentrates on software, information technology, communications and networking, commonly referred to as TMT, as well as information and medical technology, and primarily targets United States opportunities. The firm typically makes multi-million dollar investments to support scale and expansion of later-stage companies.

EVC Ventures is a private equity and venture capital firm established in 2014, with its headquarters in Miami, Florida, and additional offices in Chicago, Illinois, and Gurgaon, India. The firm focuses on early-stage and mid-stage investments, primarily in sectors such as EdTech, Artificial Intelligence, SaaS, mobile applications, security, augmented and virtual reality, drone technology, robotics, e-commerce, and gaming. EVC Ventures typically invests between $0.1 million and $5 million in its portfolio companies, and it operates two accelerator programs that provide funding ranging from $5,000 to $100,000 in exchange for equity. The firm prefers to back companies built on its I-MADE program, supporting entrepreneurs with both capital and strategic guidance to foster growth and innovation in the tech landscape.

Sica Ventures is an early-stage investment company based in Columbus, Ohio, established in 2019. The firm specializes in providing seed capital to innovative technology startups, focusing primarily on the aerospace, defense, and space sectors. Sica Ventures aims to support promising ventures through minority investments during their seed and early stages, contributing to the development of cutting-edge solutions in these critical industries.

CincyTechUSA, Investment Arm is a venture capital firm specializing in seed stage and start-up financing. They primarily invest in a variety of sectors including enterprise software, technology-enabled services, digital marketing, bioscience, and digital health care. The firm focuses on companies located in or willing to relocate to the Southwest Ohio region, specifically in the greater Cincinnati area. With investments ranging from $0.5 million to $3 million, they target companies with revenues under $5 million and fewer than 30 employees, aiming for revenue growth to $30-50 million within five to seven years. CincyTechUSA utilizes convertible debt for investments, with an interest in obtaining observer status on the Board of Directors of their portfolio companies. Founded in 2001, the firm is headquartered in Cincinnati, Ohio.

Nationwide Ventures, LLC is a financial investment firm based in Columbus, Ohio, established in 2016. The company focuses on investing in early, mid, and late-stage startups, particularly in the sectors of fintech, insurtech, and innovative solutions for retirement and financial services. By concentrating on customer-centric platforms that utilize digital, mobile, and analytics technologies, Nationwide Ventures aims to enhance the experiences of its clients. The firm typically invests between $1 million and $5 million, seeking to pilot new technologies and test novel solutions and business models.

Ikove Capital Partners is a venture development company based in Columbus, Ohio, that specializes in early-stage investments, particularly in technology commercialization. Founded in 2014 by Rodolfo Bellesi and Flavio Lobato, the firm collaborates with various U.S. research institutions through its proprietary Startup Nursery, which helps identify and validate high-impact technologies. Ikove provides essential capital and commercialization resources to assist in bridging the gap between research and development and subsequent venture capital funding. The company focuses on supporting concept technology firms by offering both investment and advisory services to facilitate their growth and market entry.

Athenian Venture Partners, established in 1997, is a venture capital firm headquartered in Athens, Ohio. It specializes in early-stage investments, focusing on innovative companies in the Information Technology, Healthcare, and Digital Health sectors across the United States. Athenian takes a hands-on, active approach, collaborating with entrepreneurs to build successful businesses and drive economic growth in its target markets. The firm aims to deliver maximum shareholder value by engaging with company management throughout the business lifecycle.

Triathlon Medical Ventures was a venture capital firm focused on life sciences, including drugs, biomedicine, medical devices, biotechnology, and diagnostics, with activity primarily in the Midwest United States. It invested in seed through expansion stages, typically in the range of 0.5 to 10 million dollars, and sought to lead investments, often taking a board seat for early rounds and a board observer role for later rounds. The firm originated in Ohio, with its base in Cincinnati and additional Midwest offices, and supported companies developing proprietary biomedical technology addressing significant healthcare needs. The firm ceased operations at the end of 2022.

Founded in 2020, Narya Capital is an early-stage venture capital firm focused on investing in technology and science sectors to address critical problems facing America. The firm supports founders and companies pioneering bold steps forward in areas such as healthcare, agriculture, defense, and financial services.

Founded in 2018, Break Trail Ventures is a venture capital firm headquartered in Columbus, Ohio with an additional office in Boulder, Colorado. The firm specializes in early-stage and growth capital investments across sectors such as consumer products, advanced manufacturing, big data, digital health, e-commerce, mobile & SaaS.

Reservoir Venture Partners, established in 2001, is a private equity firm headquartered in Ohio. It specializes in early-stage investments, focusing primarily on information technology and healthcare technology companies. The firm, founded by Chris Selland, aims to support innovative startups in these sectors, fostering their growth and success.

Vine Street Ventures is a venture capital firm based in Cincinnati, Ohio, focused on growth capital investments in internet and mobile businesses, including software and technology, media and telecommunications sectors.

Comeback Capital is a Cleveland, Ohio-based venture capital firm that backs early-stage startups, with a focus on the Midwest. It pursues pre-seed and seed investments across technology, supply chain and logistics, health tech, mobility, and the industrial Internet of Things. The firm supports portfolio companies to accelerate execution and leverages a broad network, including connections to advisors from established startup markets, to help companies scale.

Detroit Venture Partners is a Detroit-based venture capital firm that focuses on seed and early-stage technology investments across the United States, with emphasis on Detroit and Ontario. The firm backs internet, digital media, marketing technology, direct-to-consumer, sports and entertainment, social media, e-commerce, software, B2B software, mobile applications, and related sectors such as Adtech and enterprise software-as-a-service. It typically makes initial investments in the range of USD 0.25 to 0.75 million, with follow-on rounds between 2 and 3 million, and can participate up to about 3 million per investment. Founded in 2010, it aims to support entrepreneurial ventures that help rebuild the Detroit area and foster growth in technology-driven businesses.

Angel Physicians Fund, founded in 2020 and based in Powell, Ohio, operates as a venture capital firm specializing in seed-stage investments. Comprised of physicians and medical pioneers, the firm is dedicated to supporting companies in the life sciences and healthcare sectors. With a unique focus on bioscience and health-related ventures, Angel Physicians Fund seeks to leverage the expertise of its members to identify and nurture innovative healthcare solutions.

Blue Chip Venture Company is a private equity and venture capital firm established in 1990 and headquartered in Cincinnati, Ohio, with an active national footprint. It targets technology-enabled companies in digital media and big data, serving consumer advertising, and extends its investments to media, marketing, digital marketing, healthcare, education services, diversified support services, and telecommunications. The firm typically invests in privately held US companies across early to growth stages, financing rounds ranging from a few hundred thousand to several million dollars, often via convertible preferred stock, and may include bridge loans or equity components. It aims to be the lead investor, seeks a seat on the board, and targets exits within about two years through sale, recapitalization, or an IPO. The firm collaborates with existing venture syndicates and pursues opportunities nationwide, including the Midwest and Northeast regions.

Link-age Ventures is a venture capital firm based in Mason, Ohio. It focuses on investing in early to emerging-growth companies that provide products, services, and technology for the aging population, with emphasis on healthcare and information technology. The firm targets opportunities in the United States and leverages deep knowledge of the aging demographic to identify high-potential investments. It aims to support startups addressing aging-related needs in the market.

Venrock is a Palo Alto-based venture capital firm founded in 1969 as the venture capital arm of the Rockefeller family. It concentrates on seed and early-stage investments in technology and healthcare, with interests spanning information technology, life sciences and related sectors in the United States. The firm has supported a broad portfolio of companies, including Apple, Intel, Illumina, DoubleClick, Athenahealth, Gilead Sciences, Nest, SlideShare and Tudou. Venrock emphasizes long-term partnerships with entrepreneurs, combining hands-on venture support with rigorous data analysis to help startups grow into enduring companies.

JWI Capital, LLC is a private equity and venture capital firm based in Twinsburg, Ohio, founded in 2009. The firm specializes in acquiring and managing microcap companies, focusing on sectors such as manufacturing, defense, aerospace, energy, infrastructure, and transportation. JWI Capital seeks investments in companies generating revenue between $5 million and $50 million, with a preference for EBITDA of $1 to $3 million. The firm typically targets investments within a 300-mile radius of Northeast Ohio and is interested in both minority stakes—acquiring appropriate rights and protections—and control investments. JWI Capital also invests in related outsourced business services or distribution companies that support its targeted sectors, leveraging the expertise of its experienced management team to foster growth in the businesses it acquires.

Founded in 1997, Redhawk Ventures is a venture capital firm based in Oxford, Ohio. It invests primarily in seed-stage startups led by Miami University students or alumni, focusing on sectors such as fintech, consumer packaged goods, technology, and e-commerce.

Meritus Ventures is a venture capital firm based in London, Kentucky. It makes equity investments in expansion-stage private companies, with a focus on rural areas of central and southern Appalachia. The firm targets opportunities in information technology, industrials, and technology, media, and telecommunications sectors, and its activity spans across Tennessee, Kentucky, Arkansas, and Appalachian counties in Ohio, West Virginia, Virginia, North Carolina, South Carolina, Georgia, Alabama, and Mississippi. It may provide operational support to portfolio companies.

Growth Street Partners is a San Francisco-based private equity and venture capital firm that provides early-stage and growth capital to technology-enabled companies, with a focus on software-as-a-service and related SaaS-enabled services. Founded in 2016, the firm invests across the United States and typically targets investments in the range of $3 million to $10 million, often in companies with annual revenues between $1 million and $5 million. The firm emphasizes scalable software and technology-enabled services opportunities and supports growth and expansion initiatives across the U.S.

Maywic Select Investments is an independent venture capital firm based in Cincinnati, Ohio, focused on early-stage and growth-stage opportunities in consumer products and retail that promote healthy lifestyles, wellness, and wellbeing. Founded by Fred Mayerson and Chad Wick, the firm backs companies across the United States in areas including consumer products, consumer services, business services, healthcare, and technology, with an emphasis on wellness-oriented offerings.

WillowWorks, LLC is a venture capital firm based in Columbus, Ohio, specializing in early-stage investments. Established in 2016, the firm focuses on identifying innovative opportunities and forming strategic partnerships to drive growth across various markets. WillowWorks aims to support entrepreneurs and emerging companies by providing the necessary resources to foster innovation and development.

Pride Fund 1 is a venture capital firm based in Columbus, Ohio, dedicated to empowering LGBTQ+ communities through strategic investments. The firm focuses on supporting businesses that align with its mission and values, fostering growth and innovation within the LGBTQ+ sector. By investing in diverse and inclusive ventures, Pride Fund 1 aims to create a positive impact while generating financial returns.

Bruckner Ventures is an early-stage investment firm established in 2021 and located in Columbus, Ohio. The firm operates as an angel syndicate, focusing on investments in a diverse range of sectors, including business-to-business software as a service (B2B SaaS), deep technology, artificial intelligence and machine learning (AI/ML), robotics, space, electric vehicles, financial technology (fintech), cybersecurity, and transportation. Bruckner Ventures primarily targets startups based in North America, seeking to support innovative companies that are poised for growth in these dynamic industries.

Founded in 2021, Overlooked Ventures is a venture capital firm based in Columbus, Ohio. It focuses on investing in early-stage companies with historically overlooked founders, primarily in the technology sector.

Get2Volume invests in and mentors innovative enterprise technology companies in the Midwest US and Southeast Asia. Founded in Columbus, Ohio in 2004, the firm focuses on B2B technology businesses, providing operational support beyond funding to achieve venture-style returns with reduced risks.

Energy Focus designs, manufactures, markets, and installs energy-efficient lighting systems for government, marine, and commercial markets in the United States and internationally. Its offerings include military maritime LED products such as Military Intellitube, globe lights, berth lights, and fixtures, as well as Invisitube ultra-low EMI tubular LEDs and retrofit kits for the U.S. Navy and allied navies. The commercial line covers direct-wire TLED replacements for linear fluorescent lamps, Intellitube TLED replacements, LED fixtures and panels for fluorescent or HID retrofits, LED down-lights, dock lights, wall-packs, vapor-tight fixtures, retrofit kits, and RedCap emergency backup TLEDs. Energy Focus also provides installation and design/integration services. The company serves military maritime, government facilities, retailers, museums, and other industrial and general commercial markets, selling through direct sales, independent representatives, and distributors. Headquartered in Solon, Ohio, Energy Focus was founded in 1985 and was formerly known as Fiberstars.