Innovation Works

Advanced Optronics designs and manufactures implantable sensors for intraoperative monitoring. These sensors provide real-time feedback during surgeries, helping reduce trauma and preserve residual hearing, particularly in cochlear implant procedures.

Rimsys is a leading provider of Regulatory Information Management (RIM) software specifically designed for medical technology companies. The software is tailored for regulatory affairs professionals, enabling them to digitize and automate compliance processes to meet evolving global regulations. Rimsys offers a comprehensive solution that manages global Unique Device Identification (UDI) requirements and facilitates the navigation of essential regulatory components, including product registration, standards management, and regulatory intelligence. By actively tracking product registrations and monitoring relevant technical files and standards, Rimsys simplifies regulatory management for clients, transforming their operations into a more organized and efficient system for teams and international partners.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

HeadStrait Labs is a medical equipment manufacturing company focused on developing innovative devices for head and neck immobilization in pre-hospital care. The firm aims to enhance patient outcomes during ambulance transportation by providing healthcare professionals with effective solutions to stabilize patients’ head and neck during critical situations. Through its specialized products, HeadStrait Labs addresses the urgent need for reliable immobilization techniques, thereby contributing to improved safety and care in emergency medical settings.

Humotech develops the Caplex system, a modular platform that enables real-time emulation and data capture for prosthetics, orthotics, and exoskeletons. This reduces development cycles and enhances clinical decision-making, allowing researchers and clinicians to optimize assistive device performance with evidence-based insights.

Resilient Lifescience specializes in developing wearable medical devices designed to prevent opioid overdose deaths. Their innovative device detects and automatically administers naloxone, enabling timely intervention even when no one else is present.

D.Sole is a healthcare technology company focused on advancing remote patient monitoring in podiatry through innovative multimodal foot insoles. These insoles are designed for the early detection and monitoring of diabetic foot complications, including ulcers and deformities. By integrating advanced machine learning algorithms, D.Sole provides clinicians with comprehensive foot physiological data, enabling evidence-based insights for targeted treatments. The company's insoles are significantly more affordable than current market options, capable of detecting 15 types of foot complications, in contrast to competitors that only identify one. D.Sole aims to reduce healthcare costs substantially, potentially saving wound clinics over $100 million annually by lowering readmission rates for foot complications. Additionally, private insurers could save over $1 billion by reducing expenses related to amputations and wound care.

Testa-Seat is a company that specializes in developing affordable, adaptable seating solutions for children with special needs. The firm offers creatively designed, 3D-printed seating devices that enhance mobility and independence for individuals with disabilities. By providing body-contouring therapeutic positioning equipment, Testa-Seat ensures optimal support for users with mild to moderate body control. Their products are aimed at reducing the risks associated with improper seating during critical developmental stages, thereby improving comfort and wellness. Testa-Seat supplies its innovative solutions to rehabilitation centers, hospitals, and private customers, ultimately promoting better mobility and overall well-being for disabled children and adults, along with their families.

Magnify Biosciences specializes in advanced microscopy solutions, offering a high-resolution imaging platform and associated services. Their technology physically expands biological samples, enabling researchers to study complex structures and molecular interactions at the nanoscale, beyond the typical limits of light microscopy. This empowers researchers, entrepreneurs, and diagnostic labs to gain unique insights into cellular architecture, facilitating advancements in life sciences and diagnostics.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Push2Spin Technologies is dedicated to the development and commercialization of innovative solutions in the fields of plastic and podiatric surgeries. The company aims to transform the global soft tissue grafting market through its unique technology designed for small-volume fat tissue harvesting, processing, and transfer. This novel approach enhances the efficiency of clinical procedures, streamlining the process while reducing time and costs for practitioners. By focusing on disruptive technologies, Push2Spin strives to improve outcomes in soft tissue grafting, ultimately benefiting both clinicians and patients.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Founded in 2009, Setex Technologies is a Pittsburgh-based manufacturer specializing in dry adhesive technology inspired by gecko feet. They offer micro-fibrillar polymer gripping surfaces for various products, serving both consumers and manufacturers.

InnSight Technology is a biotechnology company focused on advancing the diagnostics and evaluation of eye diseases. The company specializes in developing innovative ophthalmic devices, including a novel, hand-held biosensor designed for the detection of anterior ophthalmic injuries. Additionally, InnSight Technology works on the development of nanotechnology-based medical devices aimed at addressing various clinical needs in ophthalmology. By providing these advanced tools, the company enables clinicians to enhance ocular care and improve patient outcomes in eye health.

Gus Gear is a manufacturer of wearable securement clothing designed to protect implanted medical devices and enhance patient outcomes. The company's flagship product, the Central Line Vest, safeguards central catheters from damage, breakage, and accidental removal, allowing patients to maintain their quality of life while undergoing treatment. In addition to the Central Line Vest, Gus Gear's platform offers securement solutions for various medical devices, including ostomy pouches and feeding tubes. By using innovative securement systems, Gus Gear enables patients to manage their medical challenges effectively, promoting independence and wellbeing.

Respair is a medical device company specializing in innovative airway products designed to assist clinicians and patients in critical care settings. Its proprietary technology replaces traditional inflatable cuffs with soft baffles, creating a secure seal without added pressure, thereby reducing secondary complications.

PECA Labs is a Pittsburgh-based medical device company spun out of Carnegie Mellon University and UPMC that develops polymeric heart valves and vascular grafts for pediatric congenital heart disease. Its lead product, the MASA Valve, is a synthetic valved conduit intended for pediatric right ventricular outflow tract reconstruction, leveraging ePTFE material properties and radiopaque markings to improve durability and intraoperative configurability. The company also offers exGraft, an ePTFE vascular graft with radiopaque markers. PECA Labs focuses on orphan patient populations and aims to reduce the need for multiple surgeries in children, with the MASA Valve designed to address limitations of existing conduits. The MASA Valve has received FDA Humanitarian Use Device designation, and early intraoperative implants have demonstrated reduced re-operation rates compared with alternatives. Headquartered in Pittsburgh since its founding around 2011-2012, PECA Labs pursues pediatric cardiovascular solutions with an emphasis on improving long-term outcomes for congenital heart disease patients.

Advanced Optronics designs and manufactures implantable sensors for intraoperative monitoring. These sensors provide real-time feedback during surgeries, helping reduce trauma and preserve residual hearing, particularly in cochlear implant procedures.

Telling.ai is a telehealth platform that focuses on respiratory monitoring and lung health assessment. The company analyzes voice and breath sounds to identify indicators of various medical conditions, particularly respiratory diseases and infections. Telling.ai's platform is designed to assist individuals with chronic lung conditions, enabling them to manage their health more effectively and prevent acute exacerbations. By capturing respiratory sounds in real-world settings, the platform provides real-time feedback while optimizing data quality through advanced denoising techniques. This allows for timely interventions that help avoid costly hospitalizations, ultimately benefiting the over 1 billion people affected by acute or chronic respiratory disorders.

Founded in 2019, Emergence Dental is a medical device company specializing in research and development. It focuses on designing and pre-clinically developing innovative devices for dental bone and soft tissue grafting procedures.

Lumis is a company focused on enhancing healthcare education through innovative learning systems. It develops augmented reality-driven technology that transforms traditional clinical training into immersive and accessible experiences. By offering hands-on, simulation-based training, Lumis ensures that healthcare professionals can receive high-quality education anytime and anywhere. Their products are compatible with existing training mannequins, ranging from basic CPR models to advanced, computer-controlled full-body simulators. This approach enables individualized, on-demand learning, making effective and affordable healthcare education available to students and trainees, ultimately improving patient care.

Element Exo designs and develops lightweight exoskeletons that facilitate lifting and bending tasks, reducing the risk of overuse injuries for workers engaged in repetitive lifting.

Rimsys is a leading provider of Regulatory Information Management (RIM) software specifically designed for medical technology companies. The software is tailored for regulatory affairs professionals, enabling them to digitize and automate compliance processes to meet evolving global regulations. Rimsys offers a comprehensive solution that manages global Unique Device Identification (UDI) requirements and facilitates the navigation of essential regulatory components, including product registration, standards management, and regulatory intelligence. By actively tracking product registrations and monitoring relevant technical files and standards, Rimsys simplifies regulatory management for clients, transforming their operations into a more organized and efficient system for teams and international partners.

Telling.ai is a telehealth platform that focuses on respiratory monitoring and lung health assessment. The company analyzes voice and breath sounds to identify indicators of various medical conditions, particularly respiratory diseases and infections. Telling.ai's platform is designed to assist individuals with chronic lung conditions, enabling them to manage their health more effectively and prevent acute exacerbations. By capturing respiratory sounds in real-world settings, the platform provides real-time feedback while optimizing data quality through advanced denoising techniques. This allows for timely interventions that help avoid costly hospitalizations, ultimately benefiting the over 1 billion people affected by acute or chronic respiratory disorders.

Hava Health, Inc. is a biotechnology company based in the United States that specializes in developing innovative solutions for nicotine addiction. The company manufactures a smoking cessation device, which includes a connected vape pen that integrates with a smartphone application called Hale. This digital drug therapy device aims to support individuals in their efforts to quit smoking by providing a modern approach to nicotine de-addiction. Through its technology, Hava Health seeks to enhance the effectiveness of smoking cessation efforts and improve health outcomes for users.

PECA Labs is a Pittsburgh-based medical device company spun out of Carnegie Mellon University and UPMC that develops polymeric heart valves and vascular grafts for pediatric congenital heart disease. Its lead product, the MASA Valve, is a synthetic valved conduit intended for pediatric right ventricular outflow tract reconstruction, leveraging ePTFE material properties and radiopaque markings to improve durability and intraoperative configurability. The company also offers exGraft, an ePTFE vascular graft with radiopaque markers. PECA Labs focuses on orphan patient populations and aims to reduce the need for multiple surgeries in children, with the MASA Valve designed to address limitations of existing conduits. The MASA Valve has received FDA Humanitarian Use Device designation, and early intraoperative implants have demonstrated reduced re-operation rates compared with alternatives. Headquartered in Pittsburgh since its founding around 2011-2012, PECA Labs pursues pediatric cardiovascular solutions with an emphasis on improving long-term outcomes for congenital heart disease patients.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Lumis is a company focused on enhancing healthcare education through innovative learning systems. It develops augmented reality-driven technology that transforms traditional clinical training into immersive and accessible experiences. By offering hands-on, simulation-based training, Lumis ensures that healthcare professionals can receive high-quality education anytime and anywhere. Their products are compatible with existing training mannequins, ranging from basic CPR models to advanced, computer-controlled full-body simulators. This approach enables individualized, on-demand learning, making effective and affordable healthcare education available to students and trainees, ultimately improving patient care.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Founded in 2019, Emergence Dental is a medical device company specializing in research and development. It focuses on designing and pre-clinically developing innovative devices for dental bone and soft tissue grafting procedures.

Sterile Vision offers a platform that organizes and tracks sterilizable tools and consumables throughout their use cycle in perioperative environments. Utilizing computer vision and machine learning algorithms, the platform captures images of surgical tools at multiple stages, identifies each tool, and automates tracking to minimize loss and optimize efficiency.

Founded in 2017, JuneBrain develops wearable, non-invasive imaging devices for multiple sclerosis (MS) patients to monitor their disease activity at home. This enables early detection of MS attacks and improves treatment efficacy monitoring.

Gus Gear is a manufacturer of wearable securement clothing designed to protect implanted medical devices and enhance patient outcomes. The company's flagship product, the Central Line Vest, safeguards central catheters from damage, breakage, and accidental removal, allowing patients to maintain their quality of life while undergoing treatment. In addition to the Central Line Vest, Gus Gear's platform offers securement solutions for various medical devices, including ostomy pouches and feeding tubes. By using innovative securement systems, Gus Gear enables patients to manage their medical challenges effectively, promoting independence and wellbeing.

SwifTAG Systems concepts and products were conceived by active researchers in the medical field who recognized the dramatic inefficiencies of existing small animal management systems and processes. Their mission is to bring high technology and medical research together to drive down costs and increase the time researchers spend doing actual research. They envision laboratories where animal management systems are functional, low maintenance, efficient, and as easy to use as a well-designed smartphone app. They want to see researchers focusing on medical breakthroughs, not on mindless small animal logistics. Their product lines include small animal tags, handheld and tabletop readers, cage and rack readers, whole laboratory management systems, and support software.

Lumis is a company focused on enhancing healthcare education through innovative learning systems. It develops augmented reality-driven technology that transforms traditional clinical training into immersive and accessible experiences. By offering hands-on, simulation-based training, Lumis ensures that healthcare professionals can receive high-quality education anytime and anywhere. Their products are compatible with existing training mannequins, ranging from basic CPR models to advanced, computer-controlled full-body simulators. This approach enables individualized, on-demand learning, making effective and affordable healthcare education available to students and trainees, ultimately improving patient care.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Gus Gear is a manufacturer of wearable securement clothing designed to protect implanted medical devices and enhance patient outcomes. The company's flagship product, the Central Line Vest, safeguards central catheters from damage, breakage, and accidental removal, allowing patients to maintain their quality of life while undergoing treatment. In addition to the Central Line Vest, Gus Gear's platform offers securement solutions for various medical devices, including ostomy pouches and feeding tubes. By using innovative securement systems, Gus Gear enables patients to manage their medical challenges effectively, promoting independence and wellbeing.

Symmetric Health Solutions LLC is a Pittsburgh-based company that specializes in developing software and analytics platforms for the healthcare medical supplies industry. Founded in 2018, the company provides a comprehensive suite of supply chain data solutions that include management of medical devices and pharmaceuticals, price benchmarking, product standardization, and expense tracking. Its platform enables healthcare providers to access vital data and intelligence, identify savings opportunities, and assess supply chain risks. Additionally, Symmetric Health Solutions offers professional support services to enhance the efficiency and effectiveness of supply chain operations within the healthcare sector. The company also maintains offices in New York and Washington, D.C.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

nanoGriptech, Inc. is a Pittsburgh-based company founded in 2012 that specializes in the manufacture of micro-fibrillar polymer-based dry adhesives and surfaces. Its key product offerings include Setex Gecko Tape, a reusable, residue-free tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. The company draws inspiration from nature, mimicking the adhesion mechanism of gecko feet to create durable, versatile adhesives suitable for a wide range of applications. These include wearables, sports equipment, semiconductors, robotics, medical devices, automotive, and packaging. With a focus on innovation, nanoGriptech has established partnerships with several multinational corporations and has recently initiated its first sales in the high-friction clothing material market.

AbiliLife is a Pittsburgh-based company focused on improving the lives of patients with Parkinson's disease and other neurodegenerative disorders. Founded in 2014, AbiliLife designs and manufactures biomedical solutions, including Calibrace, a brace that aids Parkinson’s disease patients in restoring equilibrium through a back tensioning system. This system enhances posture, positioning, and balance, providing postural stability and comfort for individuals with these conditions.

Impact Proteomics is a biotechnology company that develops and sells protein, peptide, and whole proteome sample preparation kits and reagents to enable reproducible, contaminant-free samples for research and drug discovery. Its product lineup includes Universal Protein Extraction and Clean Kit for peptides and for whole proteins, immunoprecipitation kits, Promtag reversible protein tagging agents, Promtag capture resin, MR-Trypsin, SB tubes, and related waste collection sets, all available online. The company supports efforts in biomarker discovery, therapeutics, and diagnostics by enabling fast, reliable preparation of samples, helping researchers accelerate development timelines.

SwifTAG Systems concepts and products were conceived by active researchers in the medical field who recognized the dramatic inefficiencies of existing small animal management systems and processes. Their mission is to bring high technology and medical research together to drive down costs and increase the time researchers spend doing actual research. They envision laboratories where animal management systems are functional, low maintenance, efficient, and as easy to use as a well-designed smartphone app. They want to see researchers focusing on medical breakthroughs, not on mindless small animal logistics. Their product lines include small animal tags, handheld and tabletop readers, cage and rack readers, whole laboratory management systems, and support software.

Optikal Care offers a subscription service delivering contact lens care products directly to customers every three months. Each box includes contact lenses, solution, cases, and additional accessories like wipes and travel kits. Founded in 2016, the company is headquartered in Norcross, Georgia.

Lumis is a company focused on enhancing healthcare education through innovative learning systems. It develops augmented reality-driven technology that transforms traditional clinical training into immersive and accessible experiences. By offering hands-on, simulation-based training, Lumis ensures that healthcare professionals can receive high-quality education anytime and anywhere. Their products are compatible with existing training mannequins, ranging from basic CPR models to advanced, computer-controlled full-body simulators. This approach enables individualized, on-demand learning, making effective and affordable healthcare education available to students and trainees, ultimately improving patient care.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Impact Proteomics is a biotechnology company that develops and sells protein, peptide, and whole proteome sample preparation kits and reagents to enable reproducible, contaminant-free samples for research and drug discovery. Its product lineup includes Universal Protein Extraction and Clean Kit for peptides and for whole proteins, immunoprecipitation kits, Promtag reversible protein tagging agents, Promtag capture resin, MR-Trypsin, SB tubes, and related waste collection sets, all available online. The company supports efforts in biomarker discovery, therapeutics, and diagnostics by enabling fast, reliable preparation of samples, helping researchers accelerate development timelines.

Symmetric Health Solutions LLC is a Pittsburgh-based company that specializes in developing software and analytics platforms for the healthcare medical supplies industry. Founded in 2018, the company provides a comprehensive suite of supply chain data solutions that include management of medical devices and pharmaceuticals, price benchmarking, product standardization, and expense tracking. Its platform enables healthcare providers to access vital data and intelligence, identify savings opportunities, and assess supply chain risks. Additionally, Symmetric Health Solutions offers professional support services to enhance the efficiency and effectiveness of supply chain operations within the healthcare sector. The company also maintains offices in New York and Washington, D.C.

PECA Labs is a Pittsburgh-based medical device company spun out of Carnegie Mellon University and UPMC that develops polymeric heart valves and vascular grafts for pediatric congenital heart disease. Its lead product, the MASA Valve, is a synthetic valved conduit intended for pediatric right ventricular outflow tract reconstruction, leveraging ePTFE material properties and radiopaque markings to improve durability and intraoperative configurability. The company also offers exGraft, an ePTFE vascular graft with radiopaque markers. PECA Labs focuses on orphan patient populations and aims to reduce the need for multiple surgeries in children, with the MASA Valve designed to address limitations of existing conduits. The MASA Valve has received FDA Humanitarian Use Device designation, and early intraoperative implants have demonstrated reduced re-operation rates compared with alternatives. Headquartered in Pittsburgh since its founding around 2011-2012, PECA Labs pursues pediatric cardiovascular solutions with an emphasis on improving long-term outcomes for congenital heart disease patients.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Lumis is a company focused on enhancing healthcare education through innovative learning systems. It develops augmented reality-driven technology that transforms traditional clinical training into immersive and accessible experiences. By offering hands-on, simulation-based training, Lumis ensures that healthcare professionals can receive high-quality education anytime and anywhere. Their products are compatible with existing training mannequins, ranging from basic CPR models to advanced, computer-controlled full-body simulators. This approach enables individualized, on-demand learning, making effective and affordable healthcare education available to students and trainees, ultimately improving patient care.

nanoGriptech, Inc. is a Pittsburgh-based company founded in 2012 that specializes in the manufacture of micro-fibrillar polymer-based dry adhesives and surfaces. Its key product offerings include Setex Gecko Tape, a reusable, residue-free tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. The company draws inspiration from nature, mimicking the adhesion mechanism of gecko feet to create durable, versatile adhesives suitable for a wide range of applications. These include wearables, sports equipment, semiconductors, robotics, medical devices, automotive, and packaging. With a focus on innovation, nanoGriptech has established partnerships with several multinational corporations and has recently initiated its first sales in the high-friction clothing material market.

AbiliLife is a Pittsburgh-based company focused on improving the lives of patients with Parkinson's disease and other neurodegenerative disorders. Founded in 2014, AbiliLife designs and manufactures biomedical solutions, including Calibrace, a brace that aids Parkinson’s disease patients in restoring equilibrium through a back tensioning system. This system enhances posture, positioning, and balance, providing postural stability and comfort for individuals with these conditions.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Ariel Precision Medicine, Inc. is an integrated genomics and digital health company focused on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases and disorders. Founded in 2015 and headquartered in Pittsburgh, Pennsylvania, the company develops innovative clinical decision support tools aimed at simplifying personalized treatment in both emergency departments and clinical settings. One of its key offerings is ArielDx, a cloud-based tool designed to enhance the diagnosis and treatment of pancreatic disease, thereby improving patient outcomes through tailored healthcare solutions.

Circadiance LLC is a medical device manufacturing company based in Turtle Creek, Pennsylvania, specializing in respiratory products for individuals with sleep-disordered breathing and those requiring non-invasive ventilation. Founded in 2006, the company develops and markets a range of innovative solutions, including the SleepWeaver all-cloth positive airway pressure masks that enhance comfort during sleep, and the SmartMonitor 2, a portable apnea monitor designed for infants that tracks heart and respiration activity. Additionally, Circadiance offers the SmartMonitor 2 Professional Series for healthcare providers, providing detailed monitoring data, as well as neonatal/pediatric electrodes and the Synergy-E Event Software for analyzing infant apnea data. The NeoPAP system is also part of their product line, designed to treat newborns experiencing respiratory distress syndrome. Circadiance products are distributed through durable medical equipment providers, online retailers, and directly to healthcare professionals, both domestically and internationally.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

PECA Labs is a Pittsburgh-based medical device company spun out of Carnegie Mellon University and UPMC that develops polymeric heart valves and vascular grafts for pediatric congenital heart disease. Its lead product, the MASA Valve, is a synthetic valved conduit intended for pediatric right ventricular outflow tract reconstruction, leveraging ePTFE material properties and radiopaque markings to improve durability and intraoperative configurability. The company also offers exGraft, an ePTFE vascular graft with radiopaque markers. PECA Labs focuses on orphan patient populations and aims to reduce the need for multiple surgeries in children, with the MASA Valve designed to address limitations of existing conduits. The MASA Valve has received FDA Humanitarian Use Device designation, and early intraoperative implants have demonstrated reduced re-operation rates compared with alternatives. Headquartered in Pittsburgh since its founding around 2011-2012, PECA Labs pursues pediatric cardiovascular solutions with an emphasis on improving long-term outcomes for congenital heart disease patients.

AbiliLife is a Pittsburgh-based company focused on improving the lives of patients with Parkinson's disease and other neurodegenerative disorders. Founded in 2014, AbiliLife designs and manufactures biomedical solutions, including Calibrace, a brace that aids Parkinson’s disease patients in restoring equilibrium through a back tensioning system. This system enhances posture, positioning, and balance, providing postural stability and comfort for individuals with these conditions.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company specializes in developing innovative solutions for stroke detection. Its flagship product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. By enabling pre-hospital providers to accurately assess patients, AlphaStroke facilitates timely triage and enhances decision-making in critical care scenarios, ultimately aiming to reduce treatment delays and improve patient outcomes.

Accel Diagnostics, LLC is a medical diagnostics company based in Pittsburgh, Pennsylvania, founded in 2008. The company develops innovative diagnostic technologies, including the pScreen Card, a disposable, credit-card-sized blood diagnostic platform that detects and quantifies biomarkers through a companion mobile application. This lab-on-chip technology allows for rapid diagnosis of infectious and chronic diseases at the point-of-care, delivering accurate results within 30 minutes and enhancing the quality of care while reducing costs. Additionally, Accel Diagnostics focuses on heart failure management, enabling patients to monitor their condition at home and allowing timely responses to heart distress before severe symptoms arise. This approach aims to reduce life-threatening events and prevent costly hospitalizations, representing a significant advancement in patient care for congestive heart failure.

nanoGriptech, Inc. is a Pittsburgh-based company founded in 2012 that specializes in the manufacture of micro-fibrillar polymer-based dry adhesives and surfaces. Its key product offerings include Setex Gecko Tape, a reusable, residue-free tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. The company draws inspiration from nature, mimicking the adhesion mechanism of gecko feet to create durable, versatile adhesives suitable for a wide range of applications. These include wearables, sports equipment, semiconductors, robotics, medical devices, automotive, and packaging. With a focus on innovation, nanoGriptech has established partnerships with several multinational corporations and has recently initiated its first sales in the high-friction clothing material market.

AbiliLife is a Pittsburgh-based company focused on improving the lives of patients with Parkinson's disease and other neurodegenerative disorders. Founded in 2014, AbiliLife designs and manufactures biomedical solutions, including Calibrace, a brace that aids Parkinson’s disease patients in restoring equilibrium through a back tensioning system. This system enhances posture, positioning, and balance, providing postural stability and comfort for individuals with these conditions.

Accel Diagnostics, LLC is a medical diagnostics company based in Pittsburgh, Pennsylvania, founded in 2008. The company develops innovative diagnostic technologies, including the pScreen Card, a disposable, credit-card-sized blood diagnostic platform that detects and quantifies biomarkers through a companion mobile application. This lab-on-chip technology allows for rapid diagnosis of infectious and chronic diseases at the point-of-care, delivering accurate results within 30 minutes and enhancing the quality of care while reducing costs. Additionally, Accel Diagnostics focuses on heart failure management, enabling patients to monitor their condition at home and allowing timely responses to heart distress before severe symptoms arise. This approach aims to reduce life-threatening events and prevent costly hospitalizations, representing a significant advancement in patient care for congestive heart failure.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

nanoGriptech, Inc. is a Pittsburgh-based company founded in 2012 that specializes in the manufacture of micro-fibrillar polymer-based dry adhesives and surfaces. Its key product offerings include Setex Gecko Tape, a reusable, residue-free tape, and the Setex Ultra-Thin Fastener, designed for seamless integration with smooth surfaces. The company draws inspiration from nature, mimicking the adhesion mechanism of gecko feet to create durable, versatile adhesives suitable for a wide range of applications. These include wearables, sports equipment, semiconductors, robotics, medical devices, automotive, and packaging. With a focus on innovation, nanoGriptech has established partnerships with several multinational corporations and has recently initiated its first sales in the high-friction clothing material market.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

RE2 Robotics, based in Pittsburgh, Pennsylvania, is a Carnegie Mellon University spin-off founded in 2001 by Jorgen Pedersen. The company specializes in the development of intelligent mobile manipulation systems that enhance remote interaction with various environments, including ground, aerial, and underwater settings. Its innovative robotic technologies are designed to improve safety and efficiency across multiple industries, including aviation, construction, defense, energy, and medical sectors. RE2 Robotics primarily serves military clients, having deployed over 400 robotic arms for explosive ordnance disposal missions. The company's intuitive systems and advanced autonomy capabilities enable users to perform dangerous tasks remotely, thereby enhancing worker safety and reducing operational costs.

NanoVision Diagnostics, Inc. is a company focused on the development and commercialization of innovative optical biomarkers for cancer detection. Founded in 2013 and based in Kittanning, Pennsylvania, the company has created a novel electro-optical cancer diagnostic system that analyzes standard biopsy slides. This system identifies molecular changes in nuclear structure that traditional pathology may overlook, allowing for the early detection and treatment of cancer. By leveraging advanced optical analysis, NanoVision Diagnostics aims to improve cancer diagnosis and enhance patient outcomes through its cutting-edge technologies.

ActivAided Orthotics LLC specializes in the design and development of biofunctional gear aimed at improving body mechanics and correcting posture, contributing to natural pain relief. The company's flagship product, a posture training shirt, is specifically engineered to alleviate back pain by addressing daily imbalances that lead to discomfort. ActivAided's offerings are applicable for various conditions, including ankylosing spondylitis, disc degeneration, and low back pain, among others. The company markets its products through an online store and medical professionals, ensuring accessibility for those in need. Founded in 2011 and based in Pittsburgh, Pennsylvania, ActivAided Orthotics emerged from a collaboration among physicians, biomedical engineers, and athletes dedicated to promoting active, pain-free living. As of 2016, it operates as a subsidiary of Elizur Corporation.

PECA Labs is a Pittsburgh-based medical device company spun out of Carnegie Mellon University and UPMC that develops polymeric heart valves and vascular grafts for pediatric congenital heart disease. Its lead product, the MASA Valve, is a synthetic valved conduit intended for pediatric right ventricular outflow tract reconstruction, leveraging ePTFE material properties and radiopaque markings to improve durability and intraoperative configurability. The company also offers exGraft, an ePTFE vascular graft with radiopaque markers. PECA Labs focuses on orphan patient populations and aims to reduce the need for multiple surgeries in children, with the MASA Valve designed to address limitations of existing conduits. The MASA Valve has received FDA Humanitarian Use Device designation, and early intraoperative implants have demonstrated reduced re-operation rates compared with alternatives. Headquartered in Pittsburgh since its founding around 2011-2012, PECA Labs pursues pediatric cardiovascular solutions with an emphasis on improving long-term outcomes for congenital heart disease patients.

Accel Diagnostics, LLC is a medical diagnostics company based in Pittsburgh, Pennsylvania, founded in 2008. The company develops innovative diagnostic technologies, including the pScreen Card, a disposable, credit-card-sized blood diagnostic platform that detects and quantifies biomarkers through a companion mobile application. This lab-on-chip technology allows for rapid diagnosis of infectious and chronic diseases at the point-of-care, delivering accurate results within 30 minutes and enhancing the quality of care while reducing costs. Additionally, Accel Diagnostics focuses on heart failure management, enabling patients to monitor their condition at home and allowing timely responses to heart distress before severe symptoms arise. This approach aims to reduce life-threatening events and prevent costly hospitalizations, representing a significant advancement in patient care for congestive heart failure.

ActivAided Orthotics LLC specializes in the design and development of biofunctional gear aimed at improving body mechanics and correcting posture, contributing to natural pain relief. The company's flagship product, a posture training shirt, is specifically engineered to alleviate back pain by addressing daily imbalances that lead to discomfort. ActivAided's offerings are applicable for various conditions, including ankylosing spondylitis, disc degeneration, and low back pain, among others. The company markets its products through an online store and medical professionals, ensuring accessibility for those in need. Founded in 2011 and based in Pittsburgh, Pennsylvania, ActivAided Orthotics emerged from a collaboration among physicians, biomedical engineers, and athletes dedicated to promoting active, pain-free living. As of 2016, it operates as a subsidiary of Elizur Corporation.

Summit Materials offers advanced materials and near-net shape manufacturing processes that save companies time and money in demanding industries such as aerospace, medical devices and oil exploration. Our patented SM-100™ alloy is used where corrosion and wear resistance are needed simultaneously. Efficient use of raw materials ensures minimal waste and environmental impact.

ViaTherm Therapeutics LLC specializes in the design and manufacture of medical devices aimed at alleviating chronic pain, muscle injuries, and joint immobility associated with aging. The company is recognized for its innovative diathermy technology, which focuses on therapeutic deep heating products. These devices provide deep and healing heat to target tissues, effectively reducing pain intensity and promoting recovery. ViaTherm's offerings include a therapeutic heating system, a deep-heat therapy system, and a consumer pain management product. The company caters to various settings, such as long-term care, rehabilitation, physical therapy, and at-home pain management, with a commitment to quality and customer satisfaction. Headquartered in Pittsburgh, Pennsylvania, ViaTherm Therapeutics was founded in 2006.

Carmell was founded in 2007 to commercialize technology developed jointly at Carnegie Mellon University and Allegheny General Hospital. The proprietary technology enables the manufacture of biologically-active plastics from blood plasma for treating injuries to bone and connective tissue. These plastics are sterile, off-the-shelf, easy to handle, shape and suture, have controlled degradation rates, contain known levels of bioactivity, and exhibit mechanical properties designed to match the repaired tissue. Carmell's plastics can be simply viewed as plastic forms of ultra-concentrated blood clots; they therefore represent the ideal biomaterials, using the body's own growth and regenerative factors to naturally promote tissue healing. The Company is focused on the sports medicine market, with products designed to accelerate healing and produce better clinical outcomes in treating injuries to connective tissue (e.g., tendons, ligaments and cartilage).

Rinovum Women's Health, Inc. develops medical devices for women. It offers Stork, a medical device that aids in natural fertility and conception in the privacy of home.

ThermalTherapeutic Systems was founded in June, 2006 by a team of highly respected experts in the field of hyperthermic perfusion technology, medical device manufacturing, molecular diagnostics and technology commercialization.