Alta Partners

Progentos Therapeutics is focused on developing innovative treatments for multiple sclerosis by harnessing the body's natural repair mechanisms. The company creates novel small-molecule therapeutics aimed at activating oligodendrocyte progenitor cells, which are crucial for myelin regeneration. This approach seeks to help patients recover lost functions and enhance their overall quality of life. Through its targeted research and development efforts, Progentos Therapeutics is dedicated to addressing the challenges associated with chronic diseases, particularly in the context of neurological disorders.

Transcarent is a consumer-directed health and care platform designed for employees of self-insured employers and their families. The company utilizes a blend of software, technology, and data science to provide consumers with unbiased information and trusted guidance. By connecting users to a network of high-value healthcare providers and services, Transcarent aims to empower individuals to make informed choices and achieve better health outcomes while navigating the complexities of the healthcare system. This approach fosters transparency and cost-effective decision-making, addressing a wide range of healthcare challenges faced by consumers today.

Edgewood Oncology is a clinical-stage biotechnology business established to fulfill the potential of BTX-A51 for patients with solid tumors that are genetically specified and hematologic malignancies. Our goal is to create a novel treatment that will prolong and enhance the lives of those with the greatest unmet medical needs.

Harbor Health is a multi-specialty clinic group based in Austin, Texas, founded in 2022. The organization focuses on delivering personalized, patient-centered healthcare by utilizing technology to enhance the patient experience. Harbor Health offers a collaborative approach to healthcare, working closely with individuals to understand their health goals and providing access to specialists when necessary. The clinic provides a variety of services, including primary care, chronic disease management, behavioral health, and overall wellness. Patients benefit from same-day and virtual appointment options, as well as conveniently located clinics, ensuring that healthcare is accessible and responsive to their needs.

Lassen Therapeutics specializes in developing monoclonal antibodies aimed at treating fibrosis, rare diseases, and oncology. The company’s primary candidate, LASN01, targets the IL-11 receptor alpha, a critical component in the IL-6 family of cytokines. IL-11 is a significant mediator of fibrosis and plays an essential role in tumor growth and the organization of the tumor microenvironment. By blocking IL-11's activity, Lassen Therapeutics seeks to provide more effective treatment options compared to traditional approaches that target other factors like TGF-β and CTGF. Through innovative antibody technologies, the company aims to deliver breakthrough therapeutics that improve the lives of patients facing serious health challenges.

MBrace Therapeutics is a privately held biopharmaceutical company focused on enhancing the quality of life for cancer patients through the development of antibody-drug conjugates (ADCs). The company specializes in creating anti-tumor monoclonal human recombinant antibodies that target specific cancer cells. By utilizing advanced technology, MBrace Therapeutics aims to deliver potent toxic drugs directly into cancer cells, allowing for more precise treatment options. This innovative approach is designed to improve therapeutic outcomes and provide healthcare professionals with better tools to combat cancer.

Free Market Health, established in 2019 and based in Pittsburgh, PA, operates a care-driven marketplace aimed at simplifying the specialty medication fulfillment process. The company provides a platform that enhances the efficiency of referral distribution and reimbursement, helping payers and specialty pharmacies navigate the complexities of the healthcare market. By identifying value drivers and accountabilities for patient referrals, Free Market Health ensures that patients have timely access to essential medications. The company's focus on optimizing resources and maximizing opportunities ultimately prioritizes the needs of patients, facilitating better health outcomes in a challenging healthcare landscape.

BetterVet is a veterinary startup founded in 2020 and based in Boston, Massachusetts. The company offers an online platform that enhances the veterinary healthcare experience by providing home visits and telehealth services. Pet owners can easily schedule virtual video consultations and arrange for in-home veterinary exams through the company's app. By focusing on mobile veterinary services, BetterVet aims to deliver convenient and accessible care for pets in the comfort of their homes.

Novome Biotechnologies, Inc. is a biotechnology company that focuses on engineering bacteria from the human gut to develop innovative treatments for chronic diseases. Its proprietary platform, which allows for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs), is designed to provide sustained therapeutic effects. Novome's lead preclinical program targets hyperoxaluria by developing a therapeutic strain of bacteria that degrades oxalate, thereby preventing kidney stone formation. The company aims to leverage its synthetic biology tools to expand its applications into additional health conditions, enhancing its ability to deliver precise therapeutic activities through engineered gut microbiota. Founded in 2015, Novome is headquartered in South San Francisco, California.

Everside Health is a direct primary care provider based in Denver, Colorado, founded in 2010. The company offers convenient on-site, near-site, and virtual care services to patients across the nation. Everside Health focuses on a data-driven, patient-centered healthcare delivery model that enhances engagement between patients and physicians. Its services include biometric screenings, health risk assessments, lifestyle coaching, and acute care. By aligning incentives among patients, physicians, and benefit providers, Everside aims to improve overall health outcomes while reducing the total cost of care.

DEM BioPharma is an immuno-oncology company that is working to eradicate cancer by targeting novel innate immune system checkpoints.

Kelonia Therapeutics is developing a new wave of genetic medicines using its next-generation vivo gene delivery platform. The company's cutting-edge in vivo gene delivery technology is simple and elegant, relying on a few potent lentiviral vector-like particles to precisely and efficiently deliver genetic cargo to the desired target tissue, and only that tissue, every time. To deliver genetic cargo only to the desired tissue, the lentiviral vector gene delivery platform employs a simple and elegant solution based on decades of research, development, and technical experience. Kelonia's mission is to develop a new wave of accessible genetic medicines that will transform the lives of patients suffering from a broad range of conditions.

Free Market Health, established in 2019 and based in Pittsburgh, PA, operates a care-driven marketplace aimed at simplifying the specialty medication fulfillment process. The company provides a platform that enhances the efficiency of referral distribution and reimbursement, helping payers and specialty pharmacies navigate the complexities of the healthcare market. By identifying value drivers and accountabilities for patient referrals, Free Market Health ensures that patients have timely access to essential medications. The company's focus on optimizing resources and maximizing opportunities ultimately prioritizes the needs of patients, facilitating better health outcomes in a challenging healthcare landscape.

Be Biopharma, Inc. is focused on developing innovative therapeutics derived from engineered B-cells to address various diseases, including cancer, autoimmune disorders, and infectious diseases. Founded in 2020 and based in Cambridge, Massachusetts, the company aims to overcome significant challenges associated with traditional cell and gene therapies, such as the limitations of dosing, unpredictable reactions in patients, and the necessity of pre-treatment chemotherapy. By leveraging precision genome editing, Be Biopharma creates durable and effective cell therapies that can be administered without toxic conditioning, thereby improving treatment options for conditions like Hemophilia B and enhancing overall patient outcomes.

ImmuneID is a precision immunology company using its proprietary platform to simultaneously identify and therapeutically target millions of antibody interactions that drive immune diseases.

Transcarent is a consumer-directed health and care platform designed for employees of self-insured employers and their families. The company utilizes a blend of software, technology, and data science to provide consumers with unbiased information and trusted guidance. By connecting users to a network of high-value healthcare providers and services, Transcarent aims to empower individuals to make informed choices and achieve better health outcomes while navigating the complexities of the healthcare system. This approach fosters transparency and cost-effective decision-making, addressing a wide range of healthcare challenges faced by consumers today.

Tyra Biosciences is a clinical-stage biotechnology company based in Carlsbad, California, that specializes in developing small molecule therapies for cancer treatment. Founded in 2018, the company aims to address drug resistance in cancer therapies through its proprietary SNÅP platform, which facilitates rapid and precise drug design by generating iterative molecular snapshots. Tyra is particularly focused on creating selective inhibitors of the Fibroblast Growth Factor Receptor (FGFR) family, which are implicated in approximately 7% of all cancers. The company's lead product candidate, TYRA-300, specifically targets FGFR3 and is initially aimed at patients with metastatic urothelial carcinoma of the bladder and urinary tract. Through its innovative approach, Tyra Biosciences seeks to improve treatment outcomes for cancer patients by providing alternatives to existing therapies.

DispatchHealth Management, LLC specializes in on-demand mobile and virtual healthcare services, aimed at delivering quality care directly to patients in their homes. Founded in 2013 and based in Denver, Colorado, the company provides a wide range of medical services, including evaluations for acute injuries and illnesses, laceration repairs, splinting, and treatment for conditions such as nosebleeds. Additionally, DispatchHealth offers vital medical procedures like Foley catheter and G-tube placements, medication administration, laboratory testing, and outpatient imaging arrangements. With a focus on convenience and integration, the company enhances the capabilities of patients' care teams while striving to reduce healthcare costs.

PatientsLikeMe, Inc. operates a healthcare data-sharing platform that facilitates the exchange of symptoms, treatments, health data, and personal experiences among patients, caregivers, healthcare professionals, and researchers. Founded in 2004 and based in Cambridge, Massachusetts, the platform serves over 600,000 members and focuses on a broad range of health conditions, including cancer, mental health, and chronic diseases. PatientsLikeMe enables users to discover new treatment options, connect with peers, and engage in health management to enhance their outcomes. The company collaborates with major pharmaceutical firms and government organizations to incorporate patient insights into research, development, and public policy. Additionally, PatientsLikeMe has published over 100 research studies, establishing itself as a credible resource for real-world disease information. It is a subsidiary of United Healthcare Services, Inc.

MBrace Therapeutics is a privately held biopharmaceutical company focused on enhancing the quality of life for cancer patients through the development of antibody-drug conjugates (ADCs). The company specializes in creating anti-tumor monoclonal human recombinant antibodies that target specific cancer cells. By utilizing advanced technology, MBrace Therapeutics aims to deliver potent toxic drugs directly into cancer cells, allowing for more precise treatment options. This innovative approach is designed to improve therapeutic outcomes and provide healthcare professionals with better tools to combat cancer.

Transcarent is a consumer-directed health and care platform designed for employees of self-insured employers and their families. The company utilizes a blend of software, technology, and data science to provide consumers with unbiased information and trusted guidance. By connecting users to a network of high-value healthcare providers and services, Transcarent aims to empower individuals to make informed choices and achieve better health outcomes while navigating the complexities of the healthcare system. This approach fosters transparency and cost-effective decision-making, addressing a wide range of healthcare challenges faced by consumers today.

Be Biopharma, Inc. is focused on developing innovative therapeutics derived from engineered B-cells to address various diseases, including cancer, autoimmune disorders, and infectious diseases. Founded in 2020 and based in Cambridge, Massachusetts, the company aims to overcome significant challenges associated with traditional cell and gene therapies, such as the limitations of dosing, unpredictable reactions in patients, and the necessity of pre-treatment chemotherapy. By leveraging precision genome editing, Be Biopharma creates durable and effective cell therapies that can be administered without toxic conditioning, thereby improving treatment options for conditions like Hemophilia B and enhancing overall patient outcomes.

DispatchHealth Management, LLC specializes in on-demand mobile and virtual healthcare services, aimed at delivering quality care directly to patients in their homes. Founded in 2013 and based in Denver, Colorado, the company provides a wide range of medical services, including evaluations for acute injuries and illnesses, laceration repairs, splinting, and treatment for conditions such as nosebleeds. Additionally, DispatchHealth offers vital medical procedures like Foley catheter and G-tube placements, medication administration, laboratory testing, and outpatient imaging arrangements. With a focus on convenience and integration, the company enhances the capabilities of patients' care teams while striving to reduce healthcare costs.

Lassen Therapeutics specializes in developing monoclonal antibodies aimed at treating fibrosis, rare diseases, and oncology. The company’s primary candidate, LASN01, targets the IL-11 receptor alpha, a critical component in the IL-6 family of cytokines. IL-11 is a significant mediator of fibrosis and plays an essential role in tumor growth and the organization of the tumor microenvironment. By blocking IL-11's activity, Lassen Therapeutics seeks to provide more effective treatment options compared to traditional approaches that target other factors like TGF-β and CTGF. Through innovative antibody technologies, the company aims to deliver breakthrough therapeutics that improve the lives of patients facing serious health challenges.

Tyra Biosciences is a clinical-stage biotechnology company based in Carlsbad, California, that specializes in developing small molecule therapies for cancer treatment. Founded in 2018, the company aims to address drug resistance in cancer therapies through its proprietary SNÅP platform, which facilitates rapid and precise drug design by generating iterative molecular snapshots. Tyra is particularly focused on creating selective inhibitors of the Fibroblast Growth Factor Receptor (FGFR) family, which are implicated in approximately 7% of all cancers. The company's lead product candidate, TYRA-300, specifically targets FGFR3 and is initially aimed at patients with metastatic urothelial carcinoma of the bladder and urinary tract. Through its innovative approach, Tyra Biosciences seeks to improve treatment outcomes for cancer patients by providing alternatives to existing therapies.

Novome Biotechnologies, Inc. is a biotechnology company that focuses on engineering bacteria from the human gut to develop innovative treatments for chronic diseases. Its proprietary platform, which allows for the controlled colonization of the gut with genetically engineered microbial medicines (GEMMs), is designed to provide sustained therapeutic effects. Novome's lead preclinical program targets hyperoxaluria by developing a therapeutic strain of bacteria that degrades oxalate, thereby preventing kidney stone formation. The company aims to leverage its synthetic biology tools to expand its applications into additional health conditions, enhancing its ability to deliver precise therapeutic activities through engineered gut microbiota. Founded in 2015, Novome is headquartered in South San Francisco, California.

Egenesis Inc. is a biotechnology company focused on gene editing and genome engineering to create human transplantable organs, tissues, and cells. Established in 2015 and headquartered in Cambridge, Massachusetts, with an additional office in New York City, Egenesis aims to address the global organ shortage by developing solid organs and therapeutic cell transplantation solutions for various diseases. The company utilizes a gene editing platform that incorporates techniques such as single-cell cloning and somatic cell nuclear transfer, which are essential for creating human-compatible organ tissues and cells. Egenesis is particularly engaged in advancing programs related to kidney and islet cell transplantation, striving to provide alternative treatment options for patients with life-threatening conditions.

Variant Bio Inc. is a biotechnology company based in Seattle, Washington, that focuses on developing therapeutics through the study of human genetic diversity. Founded in 2018, the company identifies individuals and populations that exhibit extreme traits of medical significance, utilizing advanced sequencing technologies and analytic methods to uncover the genes and pathways associated with these traits. By leveraging insights from genetic research, Variant Bio aims to discover new therapeutic targets for conditions such as neurodegenerative, autoimmune, and cardiometabolic diseases. The company's innovative approach combines statistical genetics and machine learning, enhancing the potential for genomic drug discovery to address unmet medical needs.

DispatchHealth Management, LLC specializes in on-demand mobile and virtual healthcare services, aimed at delivering quality care directly to patients in their homes. Founded in 2013 and based in Denver, Colorado, the company provides a wide range of medical services, including evaluations for acute injuries and illnesses, laceration repairs, splinting, and treatment for conditions such as nosebleeds. Additionally, DispatchHealth offers vital medical procedures like Foley catheter and G-tube placements, medication administration, laboratory testing, and outpatient imaging arrangements. With a focus on convenience and integration, the company enhances the capabilities of patients' care teams while striving to reduce healthcare costs.

Vir Biotechnology, Inc. is a clinical-stage immunology company based in San Francisco, California, that focuses on developing therapeutic products aimed at treating and preventing serious infectious diseases. The company is working on several key therapies, including VIR-2218 and VIR-3434 for hepatitis B, VIR-2482 for influenza A, VIR-1111 for human immunodeficiency virus, and VIR-2020 for tuberculosis. Vir Biotechnology employs advanced technologies and scientific expertise to manipulate immune responses and enhance pathogen-host interactions. The company has established collaborations and agreements with various organizations, including the Bill & Melinda Gates Foundation, National Institutes of Health, Brii Biosciences, Alnylam Pharmaceuticals, and others, to further its research and development efforts. Additionally, it has a manufacturing agreement with Samsung Biologics for producing antibodies related to COVID-19 treatments. Founded in 2016, Vir Biotechnology aims to leverage its innovative platforms to potentially eradicate diseases like hepatitis B, influenza A, HIV, and tuberculosis.

CuraSen Therapeutics is a biopharmaceutical company that develops orphan drugs to treat neurodegenerative diseases, including Parkinson's disease, and Alzheimer's disease.

Everside Health is a direct primary care provider based in Denver, Colorado, founded in 2010. The company offers convenient on-site, near-site, and virtual care services to patients across the nation. Everside Health focuses on a data-driven, patient-centered healthcare delivery model that enhances engagement between patients and physicians. Its services include biometric screenings, health risk assessments, lifestyle coaching, and acute care. By aligning incentives among patients, physicians, and benefit providers, Everside aims to improve overall health outcomes while reducing the total cost of care.

DispatchHealth Management, LLC specializes in on-demand mobile and virtual healthcare services, aimed at delivering quality care directly to patients in their homes. Founded in 2013 and based in Denver, Colorado, the company provides a wide range of medical services, including evaluations for acute injuries and illnesses, laceration repairs, splinting, and treatment for conditions such as nosebleeds. Additionally, DispatchHealth offers vital medical procedures like Foley catheter and G-tube placements, medication administration, laboratory testing, and outpatient imaging arrangements. With a focus on convenience and integration, the company enhances the capabilities of patients' care teams while striving to reduce healthcare costs.

Egenesis Inc. is a biotechnology company focused on gene editing and genome engineering to create human transplantable organs, tissues, and cells. Established in 2015 and headquartered in Cambridge, Massachusetts, with an additional office in New York City, Egenesis aims to address the global organ shortage by developing solid organs and therapeutic cell transplantation solutions for various diseases. The company utilizes a gene editing platform that incorporates techniques such as single-cell cloning and somatic cell nuclear transfer, which are essential for creating human-compatible organ tissues and cells. Egenesis is particularly engaged in advancing programs related to kidney and islet cell transplantation, striving to provide alternative treatment options for patients with life-threatening conditions.

GenePeeks is a genetic information company with a mission to help families protect the health of future generations. Our patented technology previews a future child’s genetic profile, identifying disease risk impossible to observe with existing pre-conception screening tools. The company’s software digitally weaves together Next-Gen sequencing data from two prospective parents, simulating genetic recombination and reduction that occurs naturally in human reproduction. The process generates analytic targets that include tens of thousands of “virtual genomes.”

Vir Biotechnology, Inc. is a clinical-stage immunology company based in San Francisco, California, that focuses on developing therapeutic products aimed at treating and preventing serious infectious diseases. The company is working on several key therapies, including VIR-2218 and VIR-3434 for hepatitis B, VIR-2482 for influenza A, VIR-1111 for human immunodeficiency virus, and VIR-2020 for tuberculosis. Vir Biotechnology employs advanced technologies and scientific expertise to manipulate immune responses and enhance pathogen-host interactions. The company has established collaborations and agreements with various organizations, including the Bill & Melinda Gates Foundation, National Institutes of Health, Brii Biosciences, Alnylam Pharmaceuticals, and others, to further its research and development efforts. Additionally, it has a manufacturing agreement with Samsung Biologics for producing antibodies related to COVID-19 treatments. Founded in 2016, Vir Biotechnology aims to leverage its innovative platforms to potentially eradicate diseases like hepatitis B, influenza A, HIV, and tuberculosis.

aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Allakos Inc. is a clinical-stage biopharmaceutical company based in Redwood City, California, founded in 2012. The company focuses on developing antibody-based therapeutics aimed at treating various conditions linked to dysregulation of the T-helper type 2 immune response, such as allergic diseases and chronic inflammation. Its lead product, antolimab (AK002), targets conditions including eosinophilic gastritis, eosinophilic gastroenteritis, chronic urticaria, indolent systemic mastocytosis, and severe allergic conjunctivitis. Additionally, Allakos is developing AK006, an antibody that targets Siglec-6, an inhibitory receptor found on mast cells. By binding to Siglec-6, AK006 is designed to enhance the receptor's natural inhibitory function, thereby reducing mast cell activation and associated inflammatory responses.

Allakos Inc. is a clinical-stage biopharmaceutical company based in Redwood City, California, founded in 2012. The company focuses on developing antibody-based therapeutics aimed at treating various conditions linked to dysregulation of the T-helper type 2 immune response, such as allergic diseases and chronic inflammation. Its lead product, antolimab (AK002), targets conditions including eosinophilic gastritis, eosinophilic gastroenteritis, chronic urticaria, indolent systemic mastocytosis, and severe allergic conjunctivitis. Additionally, Allakos is developing AK006, an antibody that targets Siglec-6, an inhibitory receptor found on mast cells. By binding to Siglec-6, AK006 is designed to enhance the receptor's natural inhibitory function, thereby reducing mast cell activation and associated inflammatory responses.

St. George's University, established in 1976 in Saint George's, Grenada, is a prominent educational institution that offers a wide range of graduate and undergraduate programs in medicine, veterinary medicine, public health, arts, and sciences. Attracting students and faculty from over 140 countries, the university provides a multicultural environment on its True Blue campus, equipped with state-of-the-art facilities. With more than 14,000 graduates, St. George's University has significantly contributed to the global workforce in healthcare and other fields. The university’s programs are recognized by various governing authorities and are affiliated with numerous educational institutions in the United States, United Kingdom, Canada, Australia, and Ireland. Beyond education, St. George's University plays a vital role in the Grenadian economy, contributing over $100 million annually through employment, local services, and community outreach initiatives. The institution also invests in public health and social services, supporting various charities and enhancing local healthcare systems. Additionally, since 2005, it has provided over $70 million in scholarships to students from the Caribbean, fostering opportunities in medicine and related fields.

Virobay Inc. is a clinical-stage biopharmaceutical company based in Menlo Park, California, focused on developing and commercializing novel therapies for various medical conditions, including neuropathic pain, autoimmune diseases, liver fibrosis, cancer, and Alzheimer's disease. The company's pipeline includes VBY-129, a cathepsin S inhibitor aimed at treating neuropathic pain and Crohn's disease, and VBY-376, an orally-administered cathepsin B inhibitor for liver fibrosis associated with nonalcoholic steatohepatitis. Additionally, VBY-825 is designed to inhibit multiple cathepsins to mitigate autoimmune attacks on bile ducts and reverse fibrosis. Virobay has also licensed VBY-891 to LEO Pharma A/S for specific dermatological uses, such as psoriasis. Founded in 2006, Virobay is dedicated to addressing significant unmet medical needs through its cysteine cathepsin platform, which focuses on developing safer and more effective treatments by regulating essential cellular processes.

Lumena Pharmaceuticals is focused on developing oral therapeutics for rare liver diseases, aiming to enhance liver function and alleviate disease symptoms. The company's clinical-stage product candidates are designed to selectively target intestinal transporters, minimizing systemic toxicity and absorption in the body. Their lead candidate, LUM001, has undergone extensive evaluation through 12 clinical studies involving over 1,400 subjects, positioning it for rapid advancement in treating cholestatic liver disease in both pediatric and adult patients. In addition to its primary goal of addressing rare liver diseases, Lumena's innovative therapeutic approach shows promise for treating metabolic liver diseases, a significant and rising health concern affecting both children and adults.

ZS Pharma is a privately held specialty pharmaceutical company based in Coppell, Texas, and Menlo Park, CA. Its core focus is the research and development of highly selective ion-trap therapies to treat serious medical conditions. The company'ss therapeutic candidate, ZS-9, is a novel treatment for hyperkalemia, a life-threatening condition that affects patients with chronic kidney disease, hypertension, diabetes, and/or chronic heart failure. Hyperkalemia is characterized by abnormally high concentrations of potassium in the blood. ZS-9 is currently being tested in late-stage clinical trials.

Evofem Biosciences is a biopharmaceutical company focused on women's sexual and reproductive health. The company has developed Phexxi, a hormone-free vaginal gel that is the first of its kind approved in the United States for the prevention of pregnancy. Additionally, Evofem is working on EVO100, a vaginal pH regulator designed to prevent the transmission of Chlamydia trachomatis and Neisseria gonorrhoeae infections in women. Headquartered in San Diego, California, Evofem aims to address unmet needs in the field of women’s health through innovative products.

Neothetics, Inc. was a clinical-stage specialty pharmaceutical company focused on developing therapeutics for the aesthetic market. Founded in 2007 and based in San Diego, California, the company aimed to address cosmetic concerns through innovative treatments. Its primary product candidate, LIPO-202, was an injectable formulation designed to reduce localized fat deposits, specifically targeting submental fat under the chin and central abdominal bulging in non-obese individuals. In January 2018, Neothetics was acquired by Evofem Biosciences in a reverse merger transaction, marking a significant shift in its business trajectory. The company was previously known as Lipothera, Inc. before rebranding in August 2014.

Sutro Biopharma is a clinical-stage drug discovery, development, and manufacturing company based in South San Francisco, California. The company specializes in creating next-generation protein therapeutics aimed at treating cancer and autoimmune disorders through its proprietary integrated cell-free protein synthesis platform, XpressCF. Among its product candidates are STRO-001, an antibody-drug conjugate targeting CD74 for patients with multiple myeloma and non-Hodgkin lymphoma, and STRO-002, which is directed against folate receptor-alpha for individuals with ovarian and endometrial cancers. Sutro Biopharma also has a collaboration and licensing agreement with Celgene Corporation to develop bispecific antibodies and antibody-drug conjugates primarily in the field of immuno-oncology. Founded in 2003, the company continues to advance its innovative therapeutic candidates through rigorous clinical development.

Larimar Therapeutics, Inc. is a clinical-stage biotechnology company based in Bala Cynwyd, Pennsylvania, dedicated to developing treatments for complex rare diseases. Its primary focus is on Friedreich's ataxia, a rare and progressive genetic disorder, for which it is advancing its lead compound, CTI-1601, through a Phase 1 clinical program. CTI-1601 is designed as a recombinant fusion protein that delivers human frataxin, an essential protein, directly to the mitochondria using a novel cell-penetrating peptide technology. In addition to Friedreich's ataxia, Larimar aims to leverage its intracellular delivery platform to create additional fusion proteins targeting other rare diseases associated with deficiencies in bioactive compounds.

Immune Design Corp. is a clinical-stage immunotherapy company headquartered in Seattle, Washington, that specializes in developing innovative treatments for cancer through in vivo methods that empower the immune system to combat disease. The company utilizes its ZVex and GLAAS discovery platforms to create a new generation of immune-based products. Its primary product candidate, G100, is currently undergoing Phase II clinical trials for follicular non-Hodgkin lymphoma, while another candidate, CMB305, focuses on enhancing tumor-specific cytotoxic T cells. Immune Design's research aims to overcome limitations of existing oncological therapies, and the company has established collaboration and license agreements with Sanofi Pasteur. Founded in 2008, Immune Design operates as a subsidiary of Merck & Co., Inc.

aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Kite Pharma is a privately held development stage biotechnology company engaged in the design and development of pioneering immune-based targeted therapies to treat different cancer indications. Kite has a portfolio of proprietary product candidates designed to stimulate the patient's own immune system to fight tumor cells. These potential therapies could provide novel strategies for the treatment and management of a wide range of tumor types.

Lumena Pharmaceuticals is focused on developing oral therapeutics for rare liver diseases, aiming to enhance liver function and alleviate disease symptoms. The company's clinical-stage product candidates are designed to selectively target intestinal transporters, minimizing systemic toxicity and absorption in the body. Their lead candidate, LUM001, has undergone extensive evaluation through 12 clinical studies involving over 1,400 subjects, positioning it for rapid advancement in treating cholestatic liver disease in both pediatric and adult patients. In addition to its primary goal of addressing rare liver diseases, Lumena's innovative therapeutic approach shows promise for treating metabolic liver diseases, a significant and rising health concern affecting both children and adults.

Esperion discovers and develops pharmaceutical products for the treatment of cardiovascular and metabolic diseases. Esperion intends to commercialize a novel class of drugs that focuses on a new treatment approach called "HDL Therapy," which is based on the Company's understanding of high-density lipoprotein, or HDL, function.

Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. The company's most advanced drug candidate, ACHN-490, has demonstrated a positive safety and dosing profile in Phase 1 clinical testing and displayed broad spectrum efficacy in preclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. In addition, the company is pursuing preclinical programs in several other areas of interest to combat the global emergence of bacterial resistance.

Carbylan Therapeutics was founded in 2004 with worldwide headquarters currently located in Palo Alto, California. They are a clinical-stage specialty pharmaceutical company focused on the development and commercialization of proprietary combination therapies. Our vision is to deliver best-in-class therapies to large growing markets where there is a clear unmet clinical need.

Evofem Biosciences is a biopharmaceutical company focused on women's sexual and reproductive health. The company has developed Phexxi, a hormone-free vaginal gel that is the first of its kind approved in the United States for the prevention of pregnancy. Additionally, Evofem is working on EVO100, a vaginal pH regulator designed to prevent the transmission of Chlamydia trachomatis and Neisseria gonorrhoeae infections in women. Headquartered in San Diego, California, Evofem aims to address unmet needs in the field of women’s health through innovative products.

Neothetics, Inc. was a clinical-stage specialty pharmaceutical company focused on developing therapeutics for the aesthetic market. Founded in 2007 and based in San Diego, California, the company aimed to address cosmetic concerns through innovative treatments. Its primary product candidate, LIPO-202, was an injectable formulation designed to reduce localized fat deposits, specifically targeting submental fat under the chin and central abdominal bulging in non-obese individuals. In January 2018, Neothetics was acquired by Evofem Biosciences in a reverse merger transaction, marking a significant shift in its business trajectory. The company was previously known as Lipothera, Inc. before rebranding in August 2014.

Larimar Therapeutics, Inc. is a clinical-stage biotechnology company based in Bala Cynwyd, Pennsylvania, dedicated to developing treatments for complex rare diseases. Its primary focus is on Friedreich's ataxia, a rare and progressive genetic disorder, for which it is advancing its lead compound, CTI-1601, through a Phase 1 clinical program. CTI-1601 is designed as a recombinant fusion protein that delivers human frataxin, an essential protein, directly to the mitochondria using a novel cell-penetrating peptide technology. In addition to Friedreich's ataxia, Larimar aims to leverage its intracellular delivery platform to create additional fusion proteins targeting other rare diseases associated with deficiencies in bioactive compounds.

Kiadis Pharma N.V. is a biopharmaceutical company based in Amsterdam, the Netherlands, specializing in cell-based immunotherapy products aimed at treating blood cancers and inherited blood disorders. The company is currently advancing K-NK002, which is undergoing Phase II clinical trials for blood cancer patients receiving haploidentical hematopoietic stem cell transplants with the post-transplant cyclophosphamide protocol. Additionally, Kiadis Pharma is developing K-NK003, currently in Phase I/II trials for patients with acute myeloid leukemia relapse or refractory cases. The preclinical product pipeline includes K-NK00X, a natural killer (NK) cell therapy candidate targeting various solid tumors. Kiadis Pharma also collaborates with several institutions, including Harbour BioMed and Erasmus Medical Center, to explore a combination of monoclonal antibodies and natural killer cells as a potential treatment for COVID-19. Founded in 1997, Kiadis Pharma is committed to addressing significant unmet medical needs in the treatment of blood-related conditions.

Applied Genetics Technologies Corporation (AGTC) is developing therapies designed to transform the lives of patients with severe diseases, offering hope to patients with unmet medical needs. With a highly specialized team of physicians and researchers, They use cutting-edge techniques to develop treatments for patients that have diseases caused by broken genes. They use gene therapy, which replaces those broken genes with normal functional genes, allowing a patient’s own body to produce proteins to treat their illness. A single injection provides long-lasting treatment, leading to a better quality of life for patients worldwide.

ZS Pharma is a privately held specialty pharmaceutical company based in Coppell, Texas, and Menlo Park, CA. Its core focus is the research and development of highly selective ion-trap therapies to treat serious medical conditions. The company'ss therapeutic candidate, ZS-9, is a novel treatment for hyperkalemia, a life-threatening condition that affects patients with chronic kidney disease, hypertension, diabetes, and/or chronic heart failure. Hyperkalemia is characterized by abnormally high concentrations of potassium in the blood. ZS-9 is currently being tested in late-stage clinical trials.

Cara Therapeutics is an emerging biotechnology company focused on developing novel therapeutics to treat human diseases associated with pain and inflammation. Cara possesses both near-term clinical development opportunities combined with proprietary approaches to developing first-in-class novel therapeutics. Cara's most advanced patented compound, CR845, is currently undergoing clinical testing for acute pain and pruritis. This best-in-class compound possesses unique analgesic and anti-inflammatory activities appropriate for multiple therapeutic applications. In addition, Cara aims to develop a future pipeline of first-in-class molecules at novel analgesic and anti-inflammatory targets using its proprietary drug screening technology.

Sutro Biopharma is a clinical-stage drug discovery, development, and manufacturing company based in South San Francisco, California. The company specializes in creating next-generation protein therapeutics aimed at treating cancer and autoimmune disorders through its proprietary integrated cell-free protein synthesis platform, XpressCF. Among its product candidates are STRO-001, an antibody-drug conjugate targeting CD74 for patients with multiple myeloma and non-Hodgkin lymphoma, and STRO-002, which is directed against folate receptor-alpha for individuals with ovarian and endometrial cancers. Sutro Biopharma also has a collaboration and licensing agreement with Celgene Corporation to develop bispecific antibodies and antibody-drug conjugates primarily in the field of immuno-oncology. Founded in 2003, the company continues to advance its innovative therapeutic candidates through rigorous clinical development.

SARcode Bioscience is a private biopharmaceutical company based in San Francisco that focuses on developing a novel class of small molecule antagonists targeting lymphocyte function-associated antigen-1 (LFA-1). These antagonists are being developed as topical agents aimed at addressing significant unmet medical needs in the fields of ophthalmology, dermatology, and other inflammatory diseases. By targeting LFA-1, SARcode aims to create innovative treatments that can improve patient outcomes in these areas.

Aerie Pharmaceuticals is an ophthalmic pharmaceutical company dedicated to the discovery, development, and commercialization of innovative therapies for various eye diseases, including glaucoma, dry eye, and retinal conditions. The company's key products include Rhopressa, a once-daily eye drop designed to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension, and Rocklatan, a fixed-dose combination of Rhopressa and latanoprost, also aimed at reducing intraocular pressure in open-angle glaucoma patients. Additionally, Aerie is developing AVX-012, a clinical-stage candidate for dry eye, alongside AR-1105 and AR-13503, which are sustained-release implants targeting retinal diseases. Founded in 2005, Aerie Pharmaceuticals is headquartered in Durham, North Carolina, and has a collaborative research agreement with DSM, reflecting its commitment to advancing eye care solutions.

Chimerix, Inc. is a biopharmaceutical company based in Durham, North Carolina, focused on developing innovative medicines for patients with serious diseases, particularly cancer and viral infections. The company is advancing several clinical-stage programs, including dociparstat sodium, a potential treatment for acute myeloid leukemia, and brincidofovir, an antiviral candidate being developed as a medical countermeasure against smallpox. Chimerix's lead antiviral candidate, CMX001, is aimed at treating life-threatening double-stranded DNA viral diseases and has shown promising results in various clinical studies involving immunocompromised patients. Additionally, the company is developing CMX157, a nucleoside analogue with activity against HIV and hepatitis B, which has completed Phase 1 trials. Chimerix has established partnerships with organizations such as the Biomedical Advanced Research and Development Authority and SymBio Pharmaceuticals to further its research and commercialization efforts. The company generates revenue through license agreements, including upfront fees, royalties, and milestone payments.

VertiFlex, Inc., a medical device company, provides minimally invasive and motion preserving spinal surgery technologies in the United States and internationally. The company offers superion interspinous spacer, a percutaneous titanium implant that fits between the spinous processes in the lumbar spine. Its Superion is a motion-preserving interspinous spacer for the treatment of moderate spinal stenosis. Vertiflex Inc was founded in 2005 and is headquartered in California, USA.

PneumRx, Inc. is a medical device company founded in 2004 and based in Mountain View, California. The company specializes in developing minimally invasive treatments specifically for patients suffering from emphysema. Its primary product is the RePneu Lung Volume Reduction Coil, an investigational device designed to improve lung function and quality of life for individuals affected by this chronic respiratory condition.

Sutro Biopharma is a clinical-stage drug discovery, development, and manufacturing company based in South San Francisco, California. The company specializes in creating next-generation protein therapeutics aimed at treating cancer and autoimmune disorders through its proprietary integrated cell-free protein synthesis platform, XpressCF. Among its product candidates are STRO-001, an antibody-drug conjugate targeting CD74 for patients with multiple myeloma and non-Hodgkin lymphoma, and STRO-002, which is directed against folate receptor-alpha for individuals with ovarian and endometrial cancers. Sutro Biopharma also has a collaboration and licensing agreement with Celgene Corporation to develop bispecific antibodies and antibody-drug conjugates primarily in the field of immuno-oncology. Founded in 2003, the company continues to advance its innovative therapeutic candidates through rigorous clinical development.

aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Pathwork Diagnostics, located in Redwood City, California, specializes in developing and delivering innovative molecular diagnostics for oncology. The company is known for its Pathwork Tissue of Origin Test, which was the first microarray-based gene expression test to receive FDA clearance. This test assists in identifying challenging tumors, including poorly differentiated, undifferentiated, and metastatic cancers, by utilizing genomic information from the tumors. Pathwork Diagnostics offers laboratory services for various specimen types, including formalin-fixed, paraffin-embedded, and frozen tissues, providing essential support in cancer diagnosis and treatment planning.

ABIONYX Pharma SA is a biopharmaceutical company based in Labege, France, specializing in the discovery and development of high-density lipoprotein (HDL) therapies aimed at treating cardiovascular and metabolic diseases. The company is advancing a portfolio of HDL therapies, including CER-001, which is in Phase II clinical trials and is designed to mimic the properties of pre-beta HDL for patients with post-acute coronary syndrome and familial primary hypoalphalipoproteinemia. Additionally, ABIONYX is developing CER-209, a candidate in Phase I trials for metabolic diseases affecting the liver, as well as atherosclerosis and non-alcoholic steato-hepatitis. The company also focuses on innovative therapies for various conditions, including renal and ophthalmological diseases, and possesses a targeted drug delivery platform for oncology applications. Formerly known as Cerenis Therapeutics, ABIONYX Pharma rebranded in August 2019, continuing its commitment to addressing unmet medical needs.

Cara Therapeutics is an emerging biotechnology company focused on developing novel therapeutics to treat human diseases associated with pain and inflammation. Cara possesses both near-term clinical development opportunities combined with proprietary approaches to developing first-in-class novel therapeutics. Cara's most advanced patented compound, CR845, is currently undergoing clinical testing for acute pain and pruritis. This best-in-class compound possesses unique analgesic and anti-inflammatory activities appropriate for multiple therapeutic applications. In addition, Cara aims to develop a future pipeline of first-in-class molecules at novel analgesic and anti-inflammatory targets using its proprietary drug screening technology.

Trevena, Inc. is a biopharmaceutical company based in Chesterbrook, Pennsylvania, established in 2007. The company is dedicated to the development and commercialization of innovative medicines aimed at treating central nervous system disorders. Its product candidates include Oliceridine injection, which is designed for managing moderate-to-severe acute pain and has completed Phase III clinical trials, and TRV250, a delta-opioid receptor agonist that has finished Phase I trials for acute migraine treatment. Other candidates in development include TRV734, targeting both acute and chronic pain, and TRV027, which is being evaluated for acute heart failure. Additionally, Trevena is collaborating with Imperial College London to study TRV027 in the context of COVID-19. The company employs a specialized approach using G protein biased ligands to enhance the efficacy and safety of its therapeutics, addressing the limitations of existing GPCR-targeted drugs.

Calistoga Pharmaceuticals, Inc. is the leader in developing innovative oral medicines targeting selected isoforms of the PI3 kinase pathway to improve the health of patients with cancer and inflammatory diseases. The PI3K pathway is a critical cellular pathway involved in cell survival and immune cell activation. Calistoga Pharmaceuticals' small-molecule therapeutic candidates inhibit specific isoforms of the PI3K pathway, providing a targeted treatment approach designed to maximize clinical outcome and limit unwanted side effects. Calistoga Pharmaceuticals' lead product, CAL-101, an oral delta-isoform selective PI3K inhibitor, has demonstrated promising clinical responses in patients with B-cell malignancies and is currently being evaluated in multiple clinical trials. In addition to CAL-101, Calistoga Pharmaceuticals' product development pipeline includes other selective PI3K inhibitors in early preclinical development or ready for initial clinical trials in patients with cancer or inflammatory diseases.

Nereus Pharmaceuticals, Inc. engages in the discovery and development of therapeutics for the treatment of oncology, infectious diseases, and inflammation. The company uses its marine microbiology technologies for the discovery and development of drug candidates. Its oncology drug candidates include NPI-2358, a tumor vascular disrupting agent for the treatment of solid tumors; and NPI-0052, a proteasome inhibitor for the treatment of solid tumors, lymphomas, and multiple myeloma. The company was founded in 1998 and is based in San Diego, California.

Virobay Inc. is a clinical-stage biopharmaceutical company based in Menlo Park, California, focused on developing and commercializing novel therapies for various medical conditions, including neuropathic pain, autoimmune diseases, liver fibrosis, cancer, and Alzheimer's disease. The company's pipeline includes VBY-129, a cathepsin S inhibitor aimed at treating neuropathic pain and Crohn's disease, and VBY-376, an orally-administered cathepsin B inhibitor for liver fibrosis associated with nonalcoholic steatohepatitis. Additionally, VBY-825 is designed to inhibit multiple cathepsins to mitigate autoimmune attacks on bile ducts and reverse fibrosis. Virobay has also licensed VBY-891 to LEO Pharma A/S for specific dermatological uses, such as psoriasis. Founded in 2006, Virobay is dedicated to addressing significant unmet medical needs through its cysteine cathepsin platform, which focuses on developing safer and more effective treatments by regulating essential cellular processes.

FoldRx Pharmaceuticals, Inc. is focused on the discovery and development of disease-modifying drug therapies targeting diseases associated with protein misfolding and amyloidosis. Established in 2003 and based in Cambridge, Massachusetts, the company has advanced clinical programs aimed at treating genetic neurologic and cardiovascular disorders, specifically transthyretin-associated amyloidoses involving polyneuropathy and cardiomyopathy. Additionally, FoldRx is engaged in research programs addressing conditions such as Parkinson's disease and cystic fibrosis. By developing therapies that address the accumulation of misfolded proteins, the company aims to enhance treatment options for healthcare professionals dealing with these complex disorders.

Achaogen is a clinical stage biopharmaceutical company focused on the discovery and development of broad-spectrum antibiotics to treat multi-drug resistant bacterial infections. The company's most advanced drug candidate, ACHN-490, has demonstrated a positive safety and dosing profile in Phase 1 clinical testing and displayed broad spectrum efficacy in preclinical studies against systemic infections caused by multi-drug resistant (MDR) Gram-negative bacteria (e.g., E. coli, K. pneumoniae, and P. aeruginosa) and MRSA. In addition, the company is pursuing preclinical programs in several other areas of interest to combat the global emergence of bacterial resistance.

TransMedics Group Inc is a commercial-stage medical technology company focused on transforming organ transplant therapy for patients with end-stage organ failure. The company has developed the Organ Care System (OCS), a portable organ perfusion, optimization, and monitoring system designed to replicate near-physiologic conditions for donor organs outside the human body. This innovative system addresses the limitations associated with traditional cold storage organ preservation, enhancing clinical outcomes and increasing transplant volumes. By providing advanced technology and clinical service solutions, TransMedics aims to improve the overall effectiveness of heart and lung transplant procedures, thereby reducing learning curves for medical professionals involved in organ transplantation.

Virobay Inc. is a clinical-stage biopharmaceutical company based in Menlo Park, California, focused on developing and commercializing novel therapies for various medical conditions, including neuropathic pain, autoimmune diseases, liver fibrosis, cancer, and Alzheimer's disease. The company's pipeline includes VBY-129, a cathepsin S inhibitor aimed at treating neuropathic pain and Crohn's disease, and VBY-376, an orally-administered cathepsin B inhibitor for liver fibrosis associated with nonalcoholic steatohepatitis. Additionally, VBY-825 is designed to inhibit multiple cathepsins to mitigate autoimmune attacks on bile ducts and reverse fibrosis. Virobay has also licensed VBY-891 to LEO Pharma A/S for specific dermatological uses, such as psoriasis. Founded in 2006, Virobay is dedicated to addressing significant unmet medical needs through its cysteine cathepsin platform, which focuses on developing safer and more effective treatments by regulating essential cellular processes.

Coapt Systems, Inc. engages in the design, development, manufacture, and marketing of bio-absorbable implants for use in soft tissue fixation during facial cosmetic surgery procedures. It offers ENDOTINE Forehead 3.0, a bioabsorbable brow fixation device; ENDOTINE Forehead Instrument Kits that comprise insertion tools, drill bits, and sterilization trays with lids; ENDOTINE Triple 3.0, the bioabsorbable brow fixation devices with disposable drill bits and insertion tools; ENDOTINE TransBleph 3.0, a bioabsorbable upper lid and brow fixation devices. The company also provides ENDOTINE Midface ST 4.5, a bioabsorbable midface suspension devices; ENDOTINE Ribbon, a bioabsorbable fixation devices; Coapt Manual Surgical Drills, the manual surgical hand drills for use with ENDOTINE implants; and SurgiWire Incisionless Dissectors, the subcutaneous The Endotine product line was bought by MicroAire, a surgical device manufacturer in Charlottesville, VA, in August 2010.

aTyr Pharma is a biotherapeutics company based in San Diego, California, specializing in the discovery and development of innovative medicines utilizing novel immunological pathways. The company focuses primarily on ATYR1923, a clinical-stage fusion protein designed to down-regulate immune engagement in interstitial lung diseases by binding to the neuropilin-2 receptor. This candidate is currently undergoing Phase 1b/2a clinical trials. aTyr Pharma has established a strong intellectual property portfolio centered around Physiocrine-based compositions and therapeutic applications, particularly in immunomodulation disorders related to inflammation and immunity. Additionally, the company has formed collaborations with several institutions, including the University of Nebraska Medical Center, CSL Behring, Boston Children’s Hospital, and the Medical University of South Carolina, to advance its research and development efforts. Founded in 2005 by a prominent scientist from The Scripps Research Institute, aTyr is supported by leading life sciences investors.

Chimerix, Inc. is a biopharmaceutical company based in Durham, North Carolina, focused on developing innovative medicines for patients with serious diseases, particularly cancer and viral infections. The company is advancing several clinical-stage programs, including dociparstat sodium, a potential treatment for acute myeloid leukemia, and brincidofovir, an antiviral candidate being developed as a medical countermeasure against smallpox. Chimerix's lead antiviral candidate, CMX001, is aimed at treating life-threatening double-stranded DNA viral diseases and has shown promising results in various clinical studies involving immunocompromised patients. Additionally, the company is developing CMX157, a nucleoside analogue with activity against HIV and hepatitis B, which has completed Phase 1 trials. Chimerix has established partnerships with organizations such as the Biomedical Advanced Research and Development Authority and SymBio Pharmaceuticals to further its research and commercialization efforts. The company generates revenue through license agreements, including upfront fees, royalties, and milestone payments.

Neothetics, Inc. was a clinical-stage specialty pharmaceutical company focused on developing therapeutics for the aesthetic market. Founded in 2007 and based in San Diego, California, the company aimed to address cosmetic concerns through innovative treatments. Its primary product candidate, LIPO-202, was an injectable formulation designed to reduce localized fat deposits, specifically targeting submental fat under the chin and central abdominal bulging in non-obese individuals. In January 2018, Neothetics was acquired by Evofem Biosciences in a reverse merger transaction, marking a significant shift in its business trajectory. The company was previously known as Lipothera, Inc. before rebranding in August 2014.

Avid Radiopharmaceuticals is a biopharmaceutical company based in Philadelphia, PA, focused on developing molecular imaging agents designed to improve the medical management of chronic diseases. The company aims to create innovative imaging compounds that can detect and monitor the early stages of pathological changes, facilitating earlier diagnoses and enhancing the management of treatment options. One of their key products, Amyvid, serves as an imaging tool for positron emission tomography, specifically targeting the detection of beta-amyloid plaques in the brain, which is crucial for understanding conditions like Alzheimer's disease. Avid's mission underscores their commitment to transforming disease management through advanced imaging technologies.

Calistoga Pharmaceuticals, Inc. is the leader in developing innovative oral medicines targeting selected isoforms of the PI3 kinase pathway to improve the health of patients with cancer and inflammatory diseases. The PI3K pathway is a critical cellular pathway involved in cell survival and immune cell activation. Calistoga Pharmaceuticals' small-molecule therapeutic candidates inhibit specific isoforms of the PI3K pathway, providing a targeted treatment approach designed to maximize clinical outcome and limit unwanted side effects. Calistoga Pharmaceuticals' lead product, CAL-101, an oral delta-isoform selective PI3K inhibitor, has demonstrated promising clinical responses in patients with B-cell malignancies and is currently being evaluated in multiple clinical trials. In addition to CAL-101, Calistoga Pharmaceuticals' product development pipeline includes other selective PI3K inhibitors in early preclinical development or ready for initial clinical trials in patients with cancer or inflammatory diseases.

Aerovance is a privately held biopharmaceutical company exclusively focused on developing and commercializing breakthrough medicines for respiratory and allergic diseases. The company maintains a solid intellectual property position with its strong portfolio of novel therapeutic candidates now in clinical development and several pre-clinical programs. The two lead products are human recombinant proteins: Aerovantâ„¢, an IL-4 and -13 receptor antagonist which is in Phase IIa studies for asthma and Aerodermâ„¢, a PEGylated IL-4 and IL-13 receptor antagonist in pre-clinical studies for eczema.

Sunesis Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to developing targeted inhibitors for treating various cancers, both hematologic and solid. Its lead candidate, vecabrutinib, is a non-covalent Bruton’s tyrosine kinase (BTK) inhibitor currently undergoing Phase 1b/2 clinical trials for chronic lymphocytic leukemia, mantle cell lymphoma, and other B-cell malignancies. The company is also advancing SNS-510, which is in preclinical studies for solid tumors and hematologic malignancies. Additionally, Sunesis is involved in partnered programs, including TAK-580, a pan-Raf inhibitor in Phase 1 trials for pediatric low-grade glioma, and vosaroxin, an anti-cancer agent that affects DNA and inhibits topoisomerase II. Collaborative efforts with Biogen Idec and Takeda Pharmaceutical focus on developing small molecule BTK inhibitors and preclinical PDK1 inhibitors, respectively. Founded in 1998, Sunesis Pharmaceuticals is headquartered in South San Francisco, California.

Sutro Biopharma is a clinical-stage drug discovery, development, and manufacturing company based in South San Francisco, California. The company specializes in creating next-generation protein therapeutics aimed at treating cancer and autoimmune disorders through its proprietary integrated cell-free protein synthesis platform, XpressCF. Among its product candidates are STRO-001, an antibody-drug conjugate targeting CD74 for patients with multiple myeloma and non-Hodgkin lymphoma, and STRO-002, which is directed against folate receptor-alpha for individuals with ovarian and endometrial cancers. Sutro Biopharma also has a collaboration and licensing agreement with Celgene Corporation to develop bispecific antibodies and antibody-drug conjugates primarily in the field of immuno-oncology. Founded in 2003, the company continues to advance its innovative therapeutic candidates through rigorous clinical development.

Aegis is a privately held company that builds solutions for embedded monitoring of advanced optical networks. The company's Active Thin Films are manufactured using proven high-volume processes with demonstrated high yield and superb uniformity. Aegis's solutions benefit from the reliability of solid-state, silicon-based design, extreme scalability, and low-cost packaging architectures.

7TM Pharma is a biotech company established in 2000 and located in Lyngby, Hovedstaden. The company specializes in discovering and developing therapeutic drugs aimed at addressing significant unmet medical needs in various conditions, particularly diabetes, obesity, gastrointestinal, metabolic, asthma, and vascular diseases. Among its key offerings are TM38837, a small molecule CB1 receptor antagonist, and TM30339, a selective NPY Y4 agonist designed to treat gastrointestinal disorders and short bowel syndrome. Additionally, the company has developed a CRTH2 antagonist, an oral medication targeting inflammatory and respiratory diseases. Through its innovative approaches, 7TM Pharma strives to provide effective treatments for patients suffering from these conditions.

Intradigm is a private biotechnology company focused on developing systematic RNA interference (RNAi) therapeutics aimed at treating serious diseases, with an initial emphasis on oncology. The company leverages its expertise in drug development and delivery to create a proprietary RNAi platform, which includes unique RNAi Nanoplex delivery technology. This technology enables the targeted delivery of RNAi therapeutics to specific tissues through systemic administration. Intradigm's portfolio encompasses RNAi molecules, biodegradable polycationic polymers for therapeutic delivery, and a range of siRNA sequences targeting various oncology and other disease-related applications.