The South Carolina Research Authority is a public nonprofit organization established in 1983 to foster innovation and economic growth in South Carolina. It supports technology-based startups and academic ventures by providing funding, mentorship, and connections to industry partners, universities, and the broader innovation ecosystem. Through its programs and partnerships, SCRA offers resources such as discounted services, access to a network of alliance partners, information on grant funding, and workspace facilities to member entities. Its core missions include cybersecurity and research security innovation, sustainability, and other initiatives aimed at solving industry needs and expanding high-wage jobs in the state.

VentureSouth is an angel investment firm and early-stage venture group based in Greenville, South Carolina, operating across the Southeast United States. It develops and manages angel investment groups and funds, connecting investors with promising startups and providing capital and strategic support. Since 2008 it has grown to include more than 550 investors across multiple groups and has deployed over $80 million in more than 100 companies. The firm focuses on scalable, technology-driven ventures with strong product-market fit and defensible advantages, investing in early-stage opportunities across industry-agnostic sectors. Typical investments range from $0.25 million to $2 million in preferred equity, with rare use of convertible debt, and the aim is to support growth with a potential high return over 3–5 years. VentureSouth emphasizes a community-driven approach, leveraging a network of advisors and syndicate partners to help portfolio companies scale in the Southeast.

Good Growth Capital is an early-stage venture capital firm based in Charleston, South Carolina. It focuses on investing in transformative science and technology companies across life sciences, data sciences, and green tech, with portfolio interests extending to medical devices and consumer technology. The firm provides funding and strategic support to help startups grow and disrupt markets, and is led by a majority women-owned team. It operates primarily in the United States and targets early-stage opportunities across software, healthcare technology, energy, materials, and related sectors.

Third Prime is a New York-based venture capital firm focused on early-stage investments in seed and startup companies across sectors, including business-to-business and financial services, consumer, and technology. Founded in 2016, the firm typically writes checks ranging from $250,000 to $3 million and operates from New York with an additional office in Mount Pleasant, South Carolina. Its portfolio spans disruptive ventures such as Moonware, Octane, Everstar, Paywatch, GreenSpark, and Cubby, illustrating a focus on automation, financing solutions, AI-enabled energy, reforming consumer credit, metals recycling, and growth support for self-storage platforms. The firm emphasizes independent thinking, partnerships with portfolio companies, and backing innovations across multiple sectors.

Healthcare Venture Partners is a venture capital firm based in Charleston, South Carolina, that invests in healthcare and life sciences companies, including digital health and health technology, as well as information technology-enabled life sciences ventures. The firm focuses on supporting innovative companies leveraging advanced technologies and typically funds mid-to-late stage ventures across healthcare, digital health, and related sectors.

IAG Capital Partners is a venture capital and growth-focused investment firm based in Charleston, South Carolina, with offices in New York City and London. Founded in 2017, it targets seed through Series D opportunities across healthcare, information technology, artificial intelligence, infrastructure, life sciences, and software as a service, providing flexible capital through a mix of common equity, preferred equity, convertible debt, mezzanine debt, structured facilities, and senior secured financing to help companies scale and achieve strategic objectives. The firm also collaborates with other debt and equity investors to participate in rounds and supports recapitalizations as part of its growth-oriented approach.

Wilmington Investor Network is an angel investment network based in Wilmington, North Carolina. It mobilizes individual investors to fund early-stage technology, biotechnology, and medical device companies located in eastern North Carolina and nearby South Carolina. Investments typically range from roughly $0.2 million to $0.5 million per round.

Orion Infrastructure Capital is a New York-based investment firm that provides capital solutions to middle-market infrastructure companies across North America and select international markets. The firm offers creative debt, equity, and growth capital to support sustainable infrastructure, energy, and industrial technologies, with a focus on environmental and social impact. It partners with portfolio companies to transform ideas into action, leveraging a team of experienced entrepreneurs and industry experts to bridge gaps between current infrastructure needs and a sustainable future. Founded in 2015, Orion emphasizes responsible investment principles and collateral-backed financing to back investments, aiming to deliver solid financial returns alongside societal benefits.

Refactor is a seed-stage venture firm led by Zal Bilimoria and based in Burlingame, California. It backs US-based hard-tech startups that build physical systems—atoms, not bits—with a founder-first approach and early checks. The firm targets durable moats, long development cycles, and sticky customer value across aerospace, energy, bio, critical materials, immune health, and AI infrastructure. Its portfolio includes Clover Health, Uniform Teeth, Kip, and other ventures that have achieved notable outcomes, including Clover Health’s public listing and Uniform Teeth’s acquisition by Impress and Kip’s acquisition by Modern Health. Refactor originated as an early spinout connected to a16z’s Bio Fund and remains focused on supporting ambitious teams rebuilding industries. Based in Burlingame, the firm invites founders to pitch and emphasizes measurable, durable impact over rapid exits.

Autotech Ventures is a venture capital firm based in Menlo Park, California, founded in 2013. It specializes in early-stage investments in the ground transportation sector, including connected, autonomous, shared-use, and electrified mobility, as well as related mobility technologies spanning the United States, Europe, and Israel. The firm backs startups that aim to transform mobility through deep tech, AI, semiconductors, electrification, and software, providing more than capital: it offers strategic guidance, access to a broad network of industry partners—fleet operators, vehicle manufacturers, energy companies, and service providers—and market intelligence to navigate the evolving transportation landscape. Autotech Ventures emphasizes a founder-first approach and leverages its ecosystem to help portfolio companies recruit talent, form partnerships, and pursue future fundraising and collaborations with corporate investors aiming to accelerate innovation in the mobility space.

8VC is a San Francisco-based technology and life sciences investment firm that partners with founders to develop transformational technologies and create long-term economic and societal value. It invests across sectors including healthcare and life sciences, energy, IT infrastructure, enterprise software, logistics, government and defense, manufacturing, consumer products, and financial services, with a focus on opportunities that leverage data-driven decision making. The firm supports portfolio companies through programs such as the 8VC Fellowship and 8VC Build and aims to back ventures where existing solutions do not meet market needs. 8VC manages a family of venture funds, including Entrepreneurs Fund II and III and multiple Fund I–III vehicles, reflecting a broad platform designed to accelerate growth and industry transformation.

Ben Franklin Technology Partners of Southeastern Pennsylvania is a nonprofit organization founded in 1982 that supports the technology ecosystem in Southeastern Pennsylvania by providing capital, guidance, and connections to early-stage technology companies. It acts as a seed-stage capital provider for the region's technology sectors, facilitates university-industry partnerships to accelerate commercialization, and undertakes initiatives to strengthen the entrepreneurial community across Philadelphia and surrounding counties, with a focus on creating jobs and fostering regional innovation.

SeedFunders is a Florida-based angel investment group and venture network that backs early-stage technology startups, primarily in Florida, including pre-seed and seed companies with minimum viable products. Founded around 2017 to 2019, it provides initial capital along with mentorship, strategic guidance, and ongoing governance support through regular steering meetings with founders and key stakeholders, and assistance with developing a minimum viable product. The firm targets technology-driven ventures across sectors such as healthcare, artificial intelligence and machine learning, cybersecurity, fintech, information technology, e-commerce, and related fields, with a focus on scalable models and disruptive technologies. While primarily active in Saint Petersburg and Orlando, SeedFunders aims to catalyze growth within the regional innovation ecosystem by helping portfolio companies prepare for larger investment rounds.

LEAD is a global venture firm focused on improving lives through investments in sports and health, operating through two core units: Funds, an institutional asset manager with a portfolio across 70+ companies and four investment funds, and Health, which supports early- to growth-stage companies applying innovation to address global health challenges. The firm emphasizes more than capital, providing strategic advice, ecosystem development, and recruiting capable leaders, supported by a globally distributed team and partner network. LEAD pursues long-term, meaningful growth for its portfolio and builds global ecosystems around sports, health, and related technologies.

Evok Innovations is a climate-focused venture capital firm based in Vancouver, Canada, founded in 2016. It backs early-stage companies developing hard tech solutions for heavy industry, focusing on energy, mining and minerals, industrial optimization, and adaptation and resilience. Beyond capital, Evok provides deep technical expertise, real-world operating experience, and access to a network of global strategic partners to help portfolio companies accelerate development, commercialization, and scale. The firm works with entrepreneurs to bridge innovation to market adoption, supporting practical, real-world outcomes. It operates in North America and has expanded its mandate with Fund II to broaden industrial verticals and increase impact across energy and infrastructure sectors.

Lerer Hippeau is a New York-based venture capital firm that focuses on early-stage investments across a wide range of sectors, including fintech, blockchain, hardware and robotics, healthcare, software, marketing services, media, and consumer goods. Founded in 2010, the firm backs founders from seed stage through near-term scaling, taking an active partner approach to help companies grow. With a broad portfolio in enterprise and consumer businesses, Lerer Hippeau is recognized as one of New York's most active early-stage investors and operates as a strategic partner for portfolio companies as they scale.

Initialized Capital is a San Francisco-based venture capital firm that backs early-stage technology startups, with a primary focus on seed investments. It provides long-term support to founders through mentorship and resources to help companies progress from inception to growth. The firm invests across a diverse set of technology sectors, including software, artificial intelligence, infrastructure, sustainability, health, consumer technology, and crypto, reflecting a broad technology orientation and commitment to disruptive innovation.

BoxGroup, founded in 2009, is a New York-based venture capital firm that backs early-stage technology startups, typically at pre-seed to Series A, across sectors including consumer, enterprise software, fintech, healthcare, life sciences, SaaS, marketplaces, e-commerce, climate tech, and frontier technologies. The firm emphasizes supporting solo founders and bold ideas, evaluating teams with conviction and aiming to fund ventures at the start of emerging markets. Investment sizes vary from tens of thousands to around a million dollars, with a global outlook and a stated focus on New York City, Silicon Valley, and Los Angeles, though geography is not a constraint. BoxGroup operates as a boutique investor in the early stages of portfolio companies, often engaging without taking board seats.

RiverPark Ventures is a New York-based early-stage, industry-agnostic venture capital firm that backs innovative companies at the intersection of enterprise technology and evolving consumer behavior. It emphasizes leadership, clear market need, and disruptive models that shorten value chains, with a preference for recurring revenue and capital-efficient, milestone-driven growth. The firm combines capital with hands-on guidance and strategic support, leveraging an operator-centric approach and research capabilities to help portfolio companies scale from initial investments through growth rounds.

Harbert Management Corporation is a privately owned investment manager focused on alternative asset classes. Headquartered in Birmingham, Alabama, the firm maintains investment teams and offices across the United States and Europe to stay close to its markets. It evaluates opportunities with a disciplined, bottom-up approach and invests capital alongside clients to seek balanced risk and return. The company spans investments in real estate, private equity, credit solutions, growth equity, infrastructure, and development projects, among others, and serves a diverse client base that includes foundations, endowments, pension funds, financial institutions, family offices, and high-net-worth individuals. Harbert Management emphasizes long-term value creation, rigorous analysis, and responsible stewardship as it builds diversified portfolios across geographies.

Second Century Ventures is a Chicago-based venture capital firm focused on accelerating innovation in real estate technology and related sectors. Backed by the National Association of REALTORS, it leverages a broad industry network to support portfolio companies, offering strategic partnerships in addition to capital. The firm invests in companies that apply artificial intelligence, digital experiences, and security across real estate, financial services, insurance, and home services. Through its REACH program, SCV provides a global community and collaborative resources to help portfolio companies scale, with partnerships spanning dozens of countries. Since its inception, it has mobilized substantial capital for its portfolio and cultivated hundreds of strategic relationships, reflecting the aim to be a catalyst for emerging technologies and talent transforming the global real estate industry.

GGV Capital is a global venture capital firm that restructured in 2024 into two brands: Granite Asia and Notable Capital. Granite Asia, headquartered in Singapore, concentrates on investments across the Asia-Pacific region, including Southeast Asia, Japan, China, India, and Australia. Notable Capital, based in Silicon Valley with offices in San Francisco and New York, concentrates on investments in the United States, Israel, Europe, and Latin America. The organization backs technology companies across early to growth stages and maintains an active portfolio strategy across regions. Notable investments include Streamlit, HashiCorp, Grab, Affirm, Poshmark, Wish, and Airbnb. The firm provides resources for founders through its platform and founder portal.

Notable Capital is a U.S.-based venture capital firm that backs early-to-growth stage companies in cloud infrastructure and business and consumer applications, with a global footprint across the United States, Israel, Europe and Latin America. The firm pursues long-term partnerships with ambitious founders seeking to reimagine industries, supporting them from early funding through scale and exits, and emphasizes technology leadership in areas such as AI, cybersecurity and related innovations alongside a deep understanding of evolving market dynamics. Its portfolio includes notable software and platform companies such as Affirm, Airbnb, HashiCorp, Quince, Slack, Vercel, Zendesk, Ibotta and Orca Security.

Greycroft is a venture capital firm that concentrates on technology startups and investments in the Internet and mobile markets. With offices in New York and Los Angeles, Greycroft leverages a wide network of media and technology industry connections to help entrepreneurs gain visibility, build strategic relationships, bring products to market, and grow successful businesses. The firm manages more than $1 billion in assets and has completed over 200 investments in companies such as Acorns, Venmo, Huffington Post, Boxed, Braintree, Scopely, Shipt, Thrive Market, Maker Studios, and The RealReal. Greycroft focuses on partnering with founders to accelerate growth and scale product-driven businesses.

Topmark Partners is a Tampa, Florida-based growth equity firm that invests in technology-enabled companies and provides capital plus strategic guidance to help rapidly expanding businesses scale. The firm emphasizes collaborative partnerships with management teams and pursues long-term growth through organic and inorganic initiatives. Topmark Partners originated as Stonehenge Growth Equity Partners and later rebranded after spinning out from Stonehenge Capital Company, leveraging a regional deal network in Florida and the Southeast. Notable portfolio outcomes include exits such as iCardiac for $240 million and ongoing growth in companies like CoachCare and Clerio Vision.

Grayhawk Capital is a Scottsdale, Arizona-based venture capital firm that provides funding and value creation for innovative technology and healthcare companies. Founded in 1999, it focuses on early and growth-stage investments across the United States, with emphasis on software as a service, cloud, cybersecurity, enterprise software, fintech, business intelligence, and health IT. The firm seeks companies led by serial entrepreneurs and strong management teams in dynamic, rapidly growing markets, and it often participates in syndicates with other institutional funds. Typical investments range from about 1 million to 15 million, with initial rounds of 1-2 million, and exits typically occur through strategic sales, IPOs, or other liquidity events. Grayhawk emphasizes active partnership and value addition to portfolio companies, and maintains a multi-sector focus within technology and healthcare IT.

Service Provider Capital is a Colorado-based venture capital firm founded in 2014 that co-invests in seed and Series A rounds led by institutional venture funds. It operates six regional funds across the Rocky Mountain, Midwest, New England, Southeast, Texas, and Pacific Northwest regions and supports more than 600 portfolio companies with a network of more than 400 strategic investors, providing access to its LP and CEO networks, and facilitating connections with venture funds, strategic partners, potential customers, and key hires. Each regional fund is managed by dedicated partners to deliver timely, hands-on support for portfolio companies. The firm maintains a presence in Colorado with operations in Vail and Golden.

New York Angels is a New York-based angel investment organization founded in 2004 as the successor to the NYNMA Angel Investor Program. It comprises over 110 active angel investors and early-stage venture funds and screens and presents early-stage technology ventures at monthly meetings. The group typically invests in early-stage opportunities ranging from $100,000 to $1,000,000, and has led deals up to $2 million. Since 2002 it has deployed more than $100 million into over 90 ventures. It receives more than 2,200 funding applications each year, selecting about 12–16 companies monthly for in-person screening, followed by an Investment Breakfast where 2–4 opportunities are presented with the aim to close the round within two months. Membership is by invitation and requires a commitment to invest at least $50,000 annually in early-stage tech deals, in addition to a $3,500 annual membership fee; entrepreneurs face no application fees. New York Angels was a founding member of the Angel Capital Association and has a history of supporting early-stage startups through mentorship and access to a broad investor network.

Stout Street Capital is a Denver-based venture capital firm founded in 2017 that backs early-stage technology companies. It focuses on business-to-business software-as-a-service and other technology sectors, including fintech, AI, healthtech, edtech, clean tech, and robotics, and emphasizes data-driven due diligence and a founder-centric approach. The firm seeks opportunities in post-revenue or post-product companies across the United States and Canada, with a preference for companies aiming to scale in underserved markets, notably the Rocky Mountain region. It is known for leveraging a broad network of co-investors and industry connections to accelerate fundraising and growth for portfolio companies.

Seae Ventures is a Boston-based venture capital firm investing in early-stage healthcare technology and services companies. The firm focuses on advancing health equity by supporting women- and BIPOC-led ventures that address financial wellness, mental health, women's health, personalized medicine, and data-enabled care. It seeks opportunities across digital health, artificial intelligence, health information technology, and tech-enabled services, including solutions that reduce costs, improve outcomes, and expand access to care in underserved communities. The investment approach emphasizes partnerships that align the interests of patients, providers, and payers, aiming to build a more just, accessible, and efficient healthcare system. The portfolio includes companies addressing areas from LGBTQ+ health and autism therapy to chronic condition management and caregiver support.

Sound Ventures is a venture capital firm based in Los Angeles, California, with activity in Beverly Hills. The firm backs early- and mid-stage technology companies, taking a hands-on approach to help founders build scalable products and infrastructure. Drawing on more than 15 years of industry insight, Sound Ventures partners with portfolio companies to achieve product-market fit, accelerate growth, and craft compelling market narratives. The firm applies thematic investing to identify emerging technical talent and opportunities, including through an AI-focused program, and maintains a network across media and technology to track trends such as artificial intelligence. Sound Ventures operates as a registered investment adviser, aligning advisory services with its investment activities. The firm aims to support visionary founders and translate technology trends into practical, market-ready solutions.

IDEA Fund Partners is a venture capital firm based in Chapel Hill, North Carolina, focusing on early-stage technology companies in North Carolina and the Southeastern United States. Founded in 2007, it seeks opportunities in technology, software, automation, big data, and healthcare, backing entrepreneurs applying innovative technology and business models to industries undergoing digital disruption. The firm emphasizes backing diverse and non-traditional founders and teams, offering guidance, networks, and strategic support beyond capital. It positions itself as one of the oldest and most active early-stage investors in the Southeast, and operates as a registered investment adviser to help overlooked founders bring disruptive ideas to market.

TechOperators is a cybersecurity-focused venture capital firm based in Atlanta, founded in 2008. It backs early-stage startups, primarily in Seed and Series A rounds, with a strong emphasis on operational expertise and hands-on support from design to scale. Led by former founders, operators, and builders, the firm relies on firsthand experience to inform investment decisions and value creation. TechOperators seeks category-defining cybersecurity companies with scalable business models and enduring security solutions, leveraging its network and practical know-how to help portfolio companies accelerate growth and navigate product, go-to-market, and operational challenges.

Blue Heron Capital is a Richmond, Virginia-based private equity and growth-focused investment firm that concentrates on growth equity and expansion opportunities in the United States. The firm targets companies in healthcare, information technology, healthcare technology, digital health, and B2B software and services, including SaaS and tech-enabled business services, often in industries where technology enables better outcomes or efficiencies. Blue Heron Capital emphasizes operational discipline and hands-on partnership, leveraging industry expertise and a broad network to support portfolio companies. It typically engages in growth investments and select lower-market buyouts or recapitalizations, investing with a preference for companies with solid revenue and positive cash flow and partnering with management to drive scale. The firm seeks to align with management teams to build durable value and deliver strategic and financial returns for investors, while maintaining a focus on the United States and on the East Coast.

C&B Capital serves as the private equity and venture capital arm of Croft & Bender, investing in privately held small and mid-sized companies. Headquartered in Atlanta, Georgia, it focuses on opportunities across the Southeast United States and targets sectors such as healthcare, information technology, business services, industrials, consumer, and telecommunications equipment and services. The firm typically makes investments ranging from about 0.25 million to 2 million dollars, often pursues majority stakes, and aims to hold investments for roughly four to five years, with openness to co-investment alongside others.

Western Technology Investment is a California-based venture debt firm founded in 1980 that provides growth capital to technology and life science companies through debt financing, and, in select cases, equity alongside debt. The firm targets venture-backed, revenue-generating firms and offers flexible, founder-friendly funding with warrants in many client companies, aiming to minimize dilution and avoid restrictive covenants. Its capital supports companies from early through public-market stages, across North America, and has a history of financing deals ranging from small to tens of millions of dollars. WTI emphasizes operational flexibility and timely capital when needed, leveraging a partner-driven, scalable approach to align with founders and management teams.

Gruhas is a venture capital firm founded in 2021 and headquartered in Bengaluru, India. It focuses on partnering with innovative individuals and companies across climate tech and sustainability, built world tech, artificial intelligence, and media and consumption. The firm engages in early, venture and debt investments, supporting start-ups, founders and teams pushing technology and innovation from seed to growth stages. Gruhas has invested in over 50 companies, creating thousands of jobs, and emphasizes thesis-driven research and strategic partnerships to fuel entrepreneurial journeys and build impactful businesses. It actively seeks new investment opportunities and evaluates pitches from founders.

Boston Harbor Angels is an angel investor group based in Boston, Massachusetts, formed in 2004. Comprising experienced business leaders, the group invests in high-growth, early-stage companies across information technology, life sciences, and other sectors, while providing strategic guidance and a broad network in addition to capital. Members invest individually rather than as a fund, collaborating on due diligence and often taking lead or syndicating with others to fund portions of rounds typically in the range of $250,000 to $1.5 million as a company nears commercialization. The group's focus is on capital-efficient ventures with clear competitive advantages and the potential for at least a 10x return within five years. A structured screening process reviews dozens of proposals monthly, selects a subset for presentations, and advances the finalists to full group diligence before investment.

AltaIR Capital is an international venture investment firm based in San Francisco that specializes in early- and growth-stage opportunities across productivity tools, future of work, software as a service, fintech, insurtech, artificial intelligence, and digital health. The firm backs startups with disruptive ideas and high return potential, and has invested in more than 400 companies, including seven unicorns, managing about $600 million in assets. Its portfolio spans key players and promising teams, and the firm has expanded its support through initiatives such as AltaLab, a startup accelerator. AltaIR emphasizes a motivated team, a clear product vision, scalable business models, and large addressable markets as core drivers of startup success.

Revolution is a Washington, D.C.-based venture capital firm founded in 2005 by Steve Case. It specializes in early- and growth-stage investments across technology-enabled sectors including software and services, consumer internet, media and entertainment, health, financial services, energy, and education, with a track record of backing entrepreneurs who build companies outside traditional coastal hubs. The firm emphasizes investing in underserved or emerging startup communities through its Rise of the Rest initiative, which spotlights regional ecosystems and funds seed- and early-stage companies outside New York, Silicon Valley, and Boston. Revolution operates multiple funds focused on entrepreneurs nationwide and seeks to partner with top-tier investors, often taking leading roles and board seats to help portfolio companies scale.

OpenView Venture Partners is a Boston-based venture capital firm founded in 2006 that focuses on technology companies in North America, with emphasis on software, business-to-business, software as a service, and cloud technologies. The firm targets early to expansion-stage opportunities and typically invests between five and fifteen million dollars per company, often in firms with annual revenue of two to twenty million. OpenView combines capital with hands-on operational support through its Expansion Platform, assisting portfolio companies with talent development, customer acquisition, and strategic partnerships to accelerate growth. The firm is registered as an investment adviser and maintains a specialized approach to helping software businesses scale in competitive markets.

First Round Capital is a San Francisco-based venture capital firm focused on pre-seed, seed, and early-stage investments in technology, healthcare, and consumer sectors. It aims to build a community of technology entrepreneurs and provides founder-focused services to help companies grow from inception, including hands-on involvement and networking opportunities. The firm has offices in San Francisco and New York and typically makes initial investments around $500,000, with a track record of helping portfolio companies raise follow-on capital and advance to later rounds. Notable portfolio companies include Uber, Square, and Warby Parker.

Grotech Ventures is a venture capital firm founded in 1984 and based in the United States that concentrates on early-stage technology companies across the country. It typically makes initial investments of 0.5 to 5 million dollars, with room for follow-on capital to support growth, and often serves as lead investor with a board seat in its portfolio companies, pursuing both control and minority equity positions and occasionally co-investing to meet larger commitments. The firm backs sectors including cybersecurity, fintech, software, digital media, e-commerce, mobile and cloud infrastructure, enterprise software, big data analytics, security technologies and healthcare information technology. It emphasizes a long-term, collaborative approach, aiming to add value beyond capital through its experience, insight and network. Grotech targets investments in underserved venture markets in the United States, including the DC region, Mid-Atlantic, Rocky Mountain states and beyond.

Greenoaks Capital Partners is a San Francisco-based venture capital firm focused on technology companies and building long-term partnerships with exceptional founders. The firm pursues concentrated, enduring investments in generational teams, supporting leaders early in their journeys with partnerships intended to last for decades. Founded in 2012, it engages in direct venture investments as well as fund-of-fund activity across geographies and industries.

Cardinal Partners is a Princeton-headquartered venture capital firm founded in 1996 that concentrates on healthcare investing across the United States. It targets early-stage and high-growth opportunities in healthcare information technology, medical technology, life sciences, and medical devices and instruments. The firm typically invests in US-based companies, often focusing on the Mid-Atlantic region, and maintains offices in Princeton and San Francisco. Cardinal Partners seeks to lead or co-lead initial financing rounds and leverages its industry experience to support portfolio companies through product development and market entry.

Alta Partners is a venture capital firm based in Jackson, Wyoming, focused on life sciences and healthcare, investing in biopharma, infectious disease, inflammation, and healthcare delivery companies, and supporting portfolio companies in developing novel therapies and improving patient outcomes. The firm emphasizes integrating technology and patient-centric approaches to advance healthcare innovation, with a track record of backing companies such as DispatchHealth, Vir Biotechnology, and Allakos.

Intersouth Partners is a Durham, North Carolina-based venture capital firm founded in 1985 that makes seed and early-stage investments in technology and life sciences companies. The firm focuses on software, semiconductors, digital media, security, medical devices, biopharmaceuticals, agricultural biotechnology and related health technologies, and seeks opportunities across the Southeast United States, including the Research Triangle region. It typically leads or co-leads initial rounds and aims to take board seats to support portfolio companies through early growth and product development. With a long history in the regional innovation ecosystem, Intersouth has invested in more than a hundred companies.

ArcTern Ventures is a Toronto-based venture capital firm founded in 2012 that specializes in earthtech and climate-focused investments. It backs early-stage startups solving climate change and sustainability challenges across six core sectors: clean energy and storage, energy efficiency, circular economy, advanced manufacturing and materials, mobility, and food systems. The firm supports portfolio companies with hands-on guidance and access to a global network, drawing on operators who have built and scaled startups. With offices in Toronto, San Francisco, and Oslo, ArcTern pursues decarbonization and sustainable growth, aiming to deliver financial value alongside meaningful climate impact.

IrishAngels is an early-stage venture firm and angel group based in Chicago that backs seed to Series A startups across the United States. It invests in software-enabled and technology-driven companies, including B2B SaaS, consumer technology, AI and machine learning, fintech, health tech, edtech, and related sectors, with a focus on founder-friendly collaboration and value beyond capital. The firm leverages its network to support portfolio companies through due diligence, post-investment guidance, and regular growth-focused check-ins. It has deployed over $100 million across numerous companies and maintains connections to the University of Notre Dame, though investments are not restricted to Notre Dame founders. Portfolio highlights include Elevate K-12, reflecting an active partnership throughout the investment lifecycle. The firm emphasizes hands-on support to help startups scale and navigate early growth challenges.

DeepWork Capital is an Orlando, Florida-based venture capital firm founded in 2015 that makes early-stage investments in technology and life sciences companies in the United States. It pursues globally scalable businesses emerging from undercapitalized U.S. markets, with a focus on Florida and the surrounding region. The firm targets seed and Series A rounds and partners with founders to provide active support and capital-efficient growth. Its portfolio includes software, healthcare technology, life sciences, space technology and other technology-enabled sectors, with an emphasis on B2B software and tech-enabled services. DeepWork Capital emphasizes hands-on engagement and aims to back technology-forward teams solving significant problems.