Red Cedar Ventures is a venture capital firm headquartered in East Lansing, Michigan, affiliated with the Michigan State University Research Foundation. It concentrates on early-stage technology investments across Michigan, backing startups that commercialize intellectual property created at Michigan State University. As the first venture fund in mid-Michigan, Red Cedar Ventures aims to support high-tech companies from formation to growth, providing capital and strategic guidance to help bring university-generated innovations to market.

Biosciences Research and Commercialization Center (BRCC) is a venture capital firm based in Kalamazoo, Michigan, established in 2003 by the Michigan Legislature and affiliated with Western Michigan University. It focuses on funding startups in the life sciences sector, specifically targeting pharmaceuticals, medical devices, and diagnostics. The BRCC aims to support companies with a significant presence in Michigan, particularly those linked to Southwest Michigan. With investments typically ranging from $25,000 to $250,000, the center provides essential startup and gap funding to entrepreneurs and scientists as they transition their innovations into the commercialization phase. Drawing on Kalamazoo's rich history in the pharmaceutical industry, the BRCC is well-positioned to leverage local scientific talent and expertise, contributing to a dynamic entrepreneurial ecosystem in the region.

Michigan Rise is a venture capital firm focused on funding Michigan technology startups to commercialize innovative technologies and spur economic development. Established in 2020 and headquartered in East Lansing, it operates as a subsidiary of the Michigan State University Foundation and administers the Pre-Seed Fund III with support from the foundation and the Michigan Economic Development Corporation. Through capital investments, coaching, and grant-funding assistance, Michigan Rise supports entrepreneurs across Michigan in sectors including advanced automotive and mobility, advanced manufacturing and materials, agricultural processing technology, alternative energy, homeland security and defense technology, information technology, life sciences, therapeutics, and medical devices. The firm partners with Michigan's tech ecosystem, including programs like Red Cedar Ventures and Spartan Innovations, to advance commercialization of new intellectual property and strengthen the state's economy.

Detroit Venture Partners is a Detroit-based venture capital firm that focuses on seed and early-stage technology investments across the United States, with emphasis on Detroit and Ontario. The firm backs internet, digital media, marketing technology, direct-to-consumer, sports and entertainment, social media, e-commerce, software, B2B software, mobile applications, and related sectors such as Adtech and enterprise software-as-a-service. It typically makes initial investments in the range of USD 0.25 to 0.75 million, with follow-on rounds between 2 and 3 million, and can participate up to about 3 million per investment. Founded in 2010, it aims to support entrepreneurial ventures that help rebuild the Detroit area and foster growth in technology-driven businesses.

Beringea is an international venture capital and private equity firm, founded in 1988 and headquartered in Michigan with offices in London and Manchester. It targets equity and debt investments in growth‑oriented companies across the United States, United Kingdom and Europe, focusing on sectors such as media, health care and life sciences, Internet technologies, advanced manufacturing, clean tech and specialized consumer goods. The firm supports entrepreneurs and management teams with capital and strategic guidance to help develop growth opportunities and create value.

Arboretum Ventures is a Michigan-based venture capital firm, founded in 2002 and headquartered in Ann Arbor. It focuses on seed-, early-, mid-, and growth-stage investments in the healthcare sector, including services, medical devices, diagnostics, healthcare information technology, therapeutics, life science tools, and technology-enabled health care delivery. The firm makes investments across the United States, with emphasis on the Midwest and Michigan, partnering with companies at various stages to support growth in healthcare. Arboretum Ventures operates as a specialized investor in healthcare, aiming to back companies developing novel tools and technologies that advance patient care.

Tappan Hill Ventures is a venture capital firm based in Ann Arbor, Michigan, founded in 2014. It invests in seed, early-stage, and later-stage companies, with a focus on software, network connectivity, and the Internet of Things.

Wakestream Ventures is a venture capital firm based in Grand Rapids, Michigan, specializing in seed and early-stage investments in technology companies. Established in 2012, the firm focuses on businesses at the intersection of hardware and software, as well as e-commerce, primarily within the United States but with a special emphasis on Michigan. Wakestream Ventures typically invests between $100,000 and $300,000 in initial funding, with the potential for follow-on investments totaling up to $1.5 million across subsequent rounds. To qualify for investment, companies must be registered as Michigan LLCs and provide progress updates within 60 to 90 days. The firm does not invest in non-profit organizations and requires investee companies to engage with its team in Grand Rapids, utilizing the region's resources for growth. Additionally, Wakestream Ventures retains the right of first refusal for future outside investments, converting this right into equity under certain conditions.

Service Provider Capital is a venture capital firm established in 2014 and based in Colorado. The firm focuses on early-stage investments, notably seed-stage opportunities, and participates as a co-investor in Series A rounds led by institutional venture funds. Its portfolio interests span a broad range of technology sectors, including artificial intelligence, machine learning, blockchain, cybersecurity, e-commerce, education technology, fintech, hardware, information technology, robotics, health, and cannabis.

Founded in 2012, eLab Ventures is a venture capital firm based in Ann Arbor, Michigan. It focuses on early-stage technology startups with disruptive innovations and capital-efficient business models, primarily outside Silicon Valley.

Michigan Angel Fund is an angel investment group based in Ann Arbor, Michigan, that provides early-stage equity funding to Michigan-based startups. It targets sectors such as information technology, software, clean technology, advanced manufacturing, life sciences, and health care, including technology, media, and telecommunications. The group typically invests between a few hundred thousand and two million dollars in companies that are near revenue or approaching break-even, helping them reach profitability and scale.

Founded in 2009, Ludlow Ventures is a Michigan-based venture capital firm specializing in early-stage investments. It focuses on technology companies across the United States, typically investing between $25,000 and $150,000 per company. Known for its straightforward approach, it aims to build trust and friendship with invested teams.

The Zell Lurie Commercialization Fund (ZLCF) is a pre-seed investment fund focused on identifying and promoting the commercialization of innovative ideas originating from the South-East Michigan region. By providing financial support and resources, the fund aims to facilitate the development of early-stage ventures, helping entrepreneurs transform their concepts into viable businesses. ZLCF plays a crucial role in fostering local economic growth and nurturing the entrepreneurial ecosystem in the area.

Huron River Ventures, established in 2010, is a Michigan-based venture capital firm that invests in early-stage companies across various industries, with a focus on energy, agriculture, and technology. The firm, headquartered in Ann Arbor, seeks innovative startups in sectors such as cloud and mobile computing, artificial intelligence, automation, clean tech, and digital transformation.

Grand Angels is an angel investment group based in Grand Rapids, Michigan, founded in 2004. It focuses on funding early-stage companies across Michigan, with a preference for West Michigan and for startups located in Kent, Ottawa, and Muskegon counties. Typical investments range from 250,000 to 1 million and span a diverse set of sectors. Beyond capital, Grand Angels provides mentoring to portfolio companies and supports a patient exit strategy, aligning funding timelines with startups' development. Since inception, the group has invested over 8 million dollars in Michigan startups.

BioStar Capital is a Michigan-based venture capital firm focused on transformative medical technologies, with a particular emphasis on cardiology. Founded by Dr. Louis A. Cannon, the firm brings together healthcare clinicians, executives, thought leaders, and financial professionals to identify and support early- and late-stage investments in medical devices and related technologies. BioStar Capital operates multiple investment funds and employs a disciplined, holistic investment approach to mitigate risk and advance cardiovascular innovations.

Grand Ventures is a Grand Rapids, Michigan-based venture capital firm founded in 2017 that specializes in seed and early-stage technology investments in the United States and Canada. The firm backs startups in B2B software and a range of technology-enabled sectors, including fintech, supply chain and logistics, digital health and healthcare IT, and developer tools, with additional focus on industries such as agriculture, food, manufacturing, transportation and mobility, and energy. It targets opportunities in the Midwest and Michigan and emphasizes added value through its Advisory Board network to help entrepreneurs sharpen strategy, build teams, and pursue successful exits.

Venture Investors is a Midwest-based venture capital firm that funds seed, early, and growth-stage startups and provides incubation financing. It concentrates on university technology transfer opportunities, particularly in the Midwest, and invests across healthcare, life sciences, agriculture, technology, clean tech, materials, energy, and hardware, including software and digital health. The firm backs companies licensed to research universities, including institutions such as the University of Wisconsin–Madison, and seeks opportunities with significant market potential and solid fundamentals. Seed investments typically range from 0.25 million to 2.5 million, with larger follow-ons possible, and the firm aims to lead rounds while also co-investing. It favors preferred equity and/or debt with warrant coverage and pursues exits through initial public offerings or sales after about five to seven years. Established in 1982, Venture Investors is headquartered in Madison, Wisconsin, with additional offices in Ann Arbor, Michigan, and Milwaukee, Wisconsin.

Founded in 2000, Lux Capital is a venture capital firm based in New York and Silicon Valley. It manages over $5 billion in assets, focusing on seed to growth investments at the intersection of technology and sciences. Lux actively supports entrepreneurs building successful businesses in high-growth sectors such as biochemistry, material science, electronics, infrastructure, aerospace, genomics, synthetic biology, and robotics.

BlueWater Angels is a network comprising over 30 high-net-worth individuals and select organizations focused on investing in promising companies. While the primary goal is to achieve a return on investment, the network places significant emphasis on supporting the entrepreneurial community to foster economic growth in mid-Michigan and the state as a whole. In its inaugural year, BlueWater Angels received funding requests from more than 100 companies, conducted detailed reviews of nearly 40, and heard presentations from a dozen firms, ultimately closing its first investment in a local advanced materials company. Currently, the annual investment capital available exceeds $1.4 million, with expectations for continued growth in the future.

Draper Triangle is a venture capital firm founded in 1999, specializing in early-stage investments. Based in Pittsburgh, Pennsylvania, with additional offices in Midwest states, the firm focuses on technology companies, particularly in software, digital media, robotics, and medical devices. Draper Triangle seeks to invest between $250,000 and $2 million initially, aiming for companies with high growth potential.

Plymouth Growth is a Michigan-based investment firm focused on growth-stage technology companies, primarily in B2B software and tech-enabled services in the United States and Canada. Based in Ann Arbor, the firm targets mid-continent opportunities and emphasizes partnering with entrepreneurs with proven business models and strong teams. It prioritizes people and culture alongside metrics, leveraging operational and advisory experience to support scalable growth. Plymouth Growth manages multiple growth funds and seeks to help portfolio companies accelerate expansion through strategic guidance and capital.

Founded in 2009 and headquartered in Detroit with an additional office in Boston, Fontinalis Partners is a venture capital firm focused on next-generation mobility solutions. It invests across stages and sizes, with a preference for taking a board seat. The firm targets technology companies in areas such as connected vehicles, data analytics, intelligent infrastructure, location-based services, and smart logistics, among others.

Founded in 2008 and headquartered in Ann Arbor, Michigan, Renaissance Venture Capital is a venture capital firm that invests in early to late-stage companies based primarily in the United States. The firm focuses on direct investments ranging from $0.5 million to $1 million per company, with a particular emphasis on supporting emerging businesses in Michigan.

Founded in 2005, Mercury Fund is a Houston-based venture capital firm with an additional office in Ann Arbor. The firm focuses on early-stage investments in technology-related companies across the United States midcontinent.

Founded in 1989, Charter Capital Partners is a premier investment banking firm headquartered in Grand Rapids, Michigan. It offers comprehensive investment banking services including mergers & acquisitions (buy-side and sell-side), succession planning, business valuation, and capital raise advisory services. Additionally, it operates as a Registered Investment Adviser managing venture capital funds and private investment vehicles.

RPM Ventures is a Michigan-based venture capital firm established in 2000 and headquartered in Ann Arbor. Originally named Waypoint Ventures, it rebranded in 2006 to reflect a Midwest-focused approach. The firm pursues seed and early-stage investments in software and technology-enabled businesses across the United States, with a particular emphasis on opportunities tied to the Midwest's innovation ecosystem. Its activity spans FinTech, InsurTech, Real Estate Tech, Mobility and Transportation, enterprise software, and related sectors such as manufacturing, data analytics, and web-based tools, including university spinouts and tech-enabled business services. RPM Ventures stresses high-tech and information-technology ventures and seeks companies with access to regional research centers or the Midwest Fortune 500 manufacturing base. By supporting early-stage startups with scalable software and technology platforms, RPM Ventures positions itself as a catalyst for growth in the Midwest and national technology ecosystems.

Accelerate Blue Fund is an early-stage venture fund that exclusively invests in startups founded on University of Michigan research.

Mercury is a purpose-built early-stage venture capital platform dedicated to supporting transformative software startups in communities across America, particularly in Middle America. The company identifies and partners with exceptional founders, offering both guidance to new entrepreneurs and resources to experienced innovators. With a focus on operationally-driven investment strategies, Mercury has generated over $9 billion in value, facilitating rapid and sustainable growth for its portfolio companies. Through its comprehensive growth partner network, Mercury aims to leverage local assets and talent, fostering entrepreneurship and innovation within the regions it serves.

Founded in 2000, General Catalyst is a venture capital firm specializing in early-stage and growth equity investments. It focuses on accelerating ideas, careers, and companies towards success by providing ongoing momentum and mentorship based on deep experience.

Michbelles is a Michigan-based investment firm established in 2011, specializing in seed and early-stage investments. The firm targets women-owned or managed enterprises within the manufacturing, life sciences, renewable energy, and technology sectors throughout the United States. Michbelles aims to support capital-efficient businesses that demonstrate unique products or services addressing urgent market needs. The firm not only seeks financial returns but also emphasizes the importance of human capital, investing in teams with strong domain expertise and a commitment to diversity in leadership. By focusing on high-growth, scalable companies, Michbelles provides vital resources and expertise to foster the development of women-led businesses in key industries.

Assembly Ventures, founded in 2020 and based in Detroit, Michigan, is a venture capital firm that specializes in investing in mobility companies. The firm focuses on supporting entrepreneurs and businesses that enhance the movement of people, goods, data, and energy in the Western world. By strategically backing early-stage ventures, Assembly Ventures aims to drive innovation within the mobility sector, addressing the evolving needs of transportation and logistics.

Prelude Ventures is a San Francisco-based venture capital firm established in 2013, dedicated to investing in early-stage startups that aim to address climate change. The firm focuses on sectors such as advanced energy, food and agriculture, transportation, logistics, advanced materials, manufacturing, and advanced computing. By supporting innovative businesses in these areas, Prelude Ventures seeks to foster the development of the next generation of companies that can significantly impact environmental sustainability and contribute to a more sustainable future.

Breakthrough Energy Ventures is an investor-led venture capital firm based in Kirkland, Washington, focused on climate and energy technology. It makes minority investments across seed, early, and later stages in companies delivering environmental services, climate technology, and cleantech solutions. The firm seeks scalable technologies that provide reliable, affordable power while reducing greenhouse gas emissions and supports innovations that address energy access, infrastructure, and transportation needs. Its mission emphasizes patient, impact-oriented investing to accelerate the transition to low-emission energy systems.

MadDog Ventures is the corporate venture capital arm of MadDog Technology, focused on investing in U.S. companies that develop and market cloud-based business applications. The firm provides capital and hands-on operating support across areas such as application development, sales, finance, marketing, and administration to help portfolio companies grow and monetize information. It is headquartered in Birmingham, Michigan, and was founded in 2016, emphasizing software-enabled business models.

Resonant Venture Partners, established in 2010 and headquartered in Ann Arbor, Michigan, is a venture capital firm focusing on seed and early-stage investments. It primarily invests in technology companies, with a particular interest in cloud infrastructure, software, and services. The firm seeks to support entrepreneurs in the United States, typically committing up to $500,000 per seed round. Resonant Venture Partners' managing directors, who are entrepreneurs themselves, actively partner with portfolio companies to navigate product, market, and operational challenges at the earliest stages.

Level Eight Ventures is a venture capital firm founded in 2018 and based in Ann Arbor, Michigan. It invests in companies across North America and Europe, focusing on artificial intelligence, clean energy, mobility, healthcare, materials and chemicals, sensors, inspection, resources and environment sectors, as well as enabling technologies in biochemistry, materials science, robotics and AI. The firm provides capital and strategic support to high-potential teams developing disruptive technologies to scale and deliver cleaner, smarter, and more sustainable solutions.

Insight Partners is a global software investor that partners with growth-stage technology and software companies. The firm focuses on growth-stage software, internet, and data services, with emphasis on fintech, cybersecurity, artificial intelligence and machine learning, DevOps, and healthcare. Based in New York City with offices in London, Tel Aviv, and Palo Alto, Insight Partners has backed more than 750 companies worldwide and has more than 55 portfolio companies that have achieved an IPO. As of 2022, the firm reports over $75 billion in assets under management. It seeks to fund and work closely with visionary executives, providing practical, hands-on software expertise to support growth from initial investment through to IPO.

Andreessen Horowitz is a venture capital firm founded in 2009 by Marc Andreessen and Ben Horowitz and based in Menlo Park, California. It funds startups across the entire lifecycle, from seed to growth, with a broad focus on software and technology-enabled businesses. The firm backs companies in software, cloud infrastructure, digital platforms, data storage, and mobile and Internet services, as well as sectors at the intersection of technology with life sciences, such as bio healthcare and computational medicine. Its investments span artificial intelligence, fintech, consumer and enterprise software, crypto and blockchain, cybersecurity, and related infrastructure. Through strategic guidance and a hands-on approach, the firm aims to help portfolio companies scale and innovate.

Founded in 2013, BELLE Capital is an angel investment group based in Douglas, Michigan. It focuses on early-stage investments in companies operating within digital mobile, internet, technology-enabled products and services, life sciences, medical devices, health, digital health, and clean technology sectors.

EDF Ventures, established in 1987, is a Michigan-based private equity firm specializing in early-stage investments across the United States. It focuses on healthcare technologies, pharmaceuticals, medical devices, diagnostics, and information technology sectors. The firm invests between $500,000 and $1.5 million initially, with follow-on investments up to $5 million. EDF Ventures leverages its extensive network to provide portfolio companies with strategic support, including management team building, partnership development, and additional funding. It prefers investments in the Midwest and Southern California, with a particular interest in technologies originating from Midwest research universities.

Founded in 2000, Gilde Healthcare Partners is a specialized investment firm focused on the healthcare sector. It manages multiple funds totaling over €800 million and invests in digital health, diagnostics, medical devices, therapeutics, and healthcare services across Europe and North America. The firm prefers to lead investments ranging from €1 million to €35 million, taking minority or majority stakes between 5% and 40%. It seeks to add value through active board participation and exits via IPOs, strategic sales, or private placements.

Ardesta, LLC, established in 1999, is a private equity and venture capital firm headquartered in Ann Arbor, Michigan, with an additional office in Hinsdale, Illinois. The company invests in various stages of technology-focused businesses, from seed to late venture, and also provides bridge and mezzanine financing. Ardesta focuses on small technology products within the sectors of communications, energy, environmental safety and security, and medical diagnostics and treatment. The firm's investment portfolio spans the Midwest, with a notable commitment to supporting and growing technology companies in Michigan.

Apjohn Ventures is a Michigan-based venture capital and private equity firm focused on early-stage life sciences and healthcare companies in the United States, with a particular emphasis on the Midwest. Founded in the early 2000s and headquartered in Kalamazoo, the firm targets startups in life sciences, pharmaceuticals, medical devices, diagnostics, biotech, and related healthcare services, supporting innovative ventures with growth potential.

Founded in 2017, Tamarind Hill is a venture capital firm based in Dublin, Ohio. It provides entrepreneurial stage capital to SaaS companies focused on B2B markets such as healthcare IT and enterprise IT, primarily investing throughout the Midwestern U.S.

Capital Midwest Fund is a venture capital firm based in Mequon, Wisconsin. It specializes in early-stage investments across various sectors including life sciences, information technology, advanced manufacturing, B2B, and healthcare, with a focus on companies located in the Midwest region of the United States.

CourtsideVC, founded in 2015, is a private equity firm based in New York that focuses on seed and series B stage investments in the sports and technology industries across the United States. Specializing in startup, seed, and early stage investments, CourtsideVC targets innovative technology disrupters in sports and media technology sectors, including virtual reality, data analytics, and e-sports ventures. With initial investments ranging from $200,000 to $1.5 million, the firm operates both domestically and internationally, with offices in Detroit, Michigan and New York, New York.

Arbor Partners is a venture capital firm headquartered in Ann Arbor, Michigan. It seeks to invest in information technology, next-generation enterprise software, semiconductors, advanced materials, and software-as-a-service, with a primary focus on Midwest United States companies and occasional co-investments outside the region.

MK Capital is a Chicago-area venture capital and private equity firm that invests in emerging technology companies across the early and growth stages in the United States. Founded in 2003, the firm focuses on software and technology-enabled businesses, including digital software, digital media, data center automation, technology-enabled business services, and education technology. It provides multi-stage capital and leverages deep operating experience to help portfolio companies scale, with active board involvement and collaborative support on strategy, operations and technology. The firm maintains offices in Northbrook, Illinois; Ann Arbor, Michigan; and Santa Monica, California, and manages over $500 million in assets.

Khosla Ventures is a California-based venture capital firm founded in 2004 by Vinod Khosla. It provides capital and strategic guidance to startups across stages, focusing on technology-driven companies in areas such as artificial intelligence, climate and sustainability, enterprise software and services, fintech, digital health, medical technology and diagnostics, therapeutics, consumer products, and frontier technologies. The firm backs bold ventures with the potential to disrupt markets and improve lives, supporting companies from early to growth stages and working closely with entrepreneurs to apply science, technology and innovative business models. While primarily investing in North American technology companies, Khosla Ventures pursues opportunities globally and emphasizes experimentation and impact alongside financial returns. The firm also maintains related impact initiatives that support entrepreneurs addressing socio-economic challenges in emerging markets.