Gilde Healthcare

MicroTransponder, Inc. is a medical device company based in Austin, Texas, specializing in the development and commercialization of neurostimulation devices aimed at treating various neurological diseases. Founded in 2007, the company focuses on therapies that utilize vagus nerve stimulation (VNS) to address conditions such as tinnitus, chronic pain, and rehabilitation for stroke survivors. Its notable products include the Serenity System, designed specifically for tinnitus treatment, and the Vivistim device, which is FDA approved for assisting ischemic stroke survivors with moderate to severe upper limb impairment. Through its innovative approaches, MicroTransponder aims to enhance recovery and improve the quality of life for individuals affected by these neurological conditions.

Shoulder Innovations, Inc. is a medical device company based in Holland, Michigan, specializing in orthopedic solutions for shoulder replacement surgery. Founded in 2009, the company has developed an advanced Total Shoulder Replacement System that features innovative inset glenoid fixation technology, addressing the critical issue of glenoid implant stability during shoulder arthroplasty. This technology not only enhances the robustness of the glenoid platform but also simplifies the surgical instrumentation, aiming to reduce operative time and costs. The company's products are marketed through distribution partners in the United States and are designed to improve patient outcomes by minimizing the risk of glenoid loosening, which is a leading cause of revision surgeries. By focusing on reliable fixation and simplified surgical techniques, Shoulder Innovations strives to enhance the efficacy and longevity of shoulder implants while potentially lowering overall healthcare costs.

GT Medical Technologies, Inc. is a medical device company based in Tempe, Arizona, dedicated to improving the lives of patients with brain tumors. Founded in 2017, the company has developed an innovative treatment approach through its flagship product, GammaTile, which combines a biocompatible, conformable collagen matrix with brachytherapy radiation seeds. This technology is designed to address the limitations of existing treatments for recurrent brain tumors, providing a bioresorbable solution that enhances treatment efficacy. GammaTile is protected by multiple patents and has the potential to benefit a significant patient population, with an estimated 176,000 patients diagnosed annually in the United States. To date, clinical trials at Barrow Neurological Institute have demonstrated promising outcomes, with significant clinical improvements observed in patients treated with this novel device.

Alleviant Medical, Inc. is a medical device company headquartered in Austin, Texas, that specializes in developing innovative therapies for congestive heart failure. Founded in 2017, the company has created a proprietary transcatheter device that addresses the symptoms of heart failure by relieving pressure buildup in the left atrium of the heart. This minimally-invasive technology aims to improve the quality of life for patients and significantly reduce hospital admissions related to heart failure exacerbations, ultimately benefiting millions of Americans affected by this condition. Alleviant Medical is committed to transforming the treatment landscape for congestive heart failure through its advanced medical devices.

Noema Pharma AG is a biotechnology company based in Basel, Switzerland, founded in 2019. The company focuses on developing innovative therapeutic products for orphan neurological disorders characterized by imbalanced neuronal networks. Its research and development efforts are dedicated to addressing disabling symptoms associated with conditions affecting the nervous system, such as Tuberous Sclerosis Complex, Trigeminal Neuralgia, and Tourette syndrome. By creating novel therapies, Noema Pharma aims to enhance the quality of life and improve patient outcomes for those suffering from these challenging disorders.

SynOx Therapeutics is a clinical stage biopharmaceutical company based in Dublin, Ireland, established in 2019. The company focuses on the development of innovative therapies for cancer, particularly through its lead product, emactuzumab. This humanized monoclonal antibody specifically targets the CSF-1 receptor, aiming to deplete macrophages within tumor tissues. SynOx Therapeutics is dedicated to addressing the unmet clinical needs of patients suffering from diffuse tenosynovial giant cell tumors and other conditions associated with macrophage activity, ultimately striving to provide best-in-class treatment options that enhance patient quality of life. The company is backed by experienced investors with a strong track record in biopharmaceutical development.

Purespring Therapeutics is a biotechnology company specializing in the development of gene therapies for various kidney diseases. It focuses on targeting podocytes, specialized cells within the kidneys, using adeno-associated virus (AAV) vectors. The company aims to address unmet needs in renal conditions and has established an in-vivo functional screening platform to identify protective factors that could potentially benefit multiple kidney diseases.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Draupnir Bio is focused on developing innovative cholesterol-lowering medications that aim to prevent heart blood clots more effectively than existing treatments. The company leverages a platform technology that explores the glycome to create novel therapeutics through advanced techniques in array technology, protein chemistry, and carbohydrate chemistry. Draupnir Bio specializes in synthesizing, screening, and selecting potent heparan sulfate glycomimetic drug candidates that address cardiovascular, inflammatory, and infectious diseases. Additionally, the company is working on protein degraders that target extracellular disease proteins, which could potentially address a wide range of unmet therapeutic needs across various medical conditions, providing more convenient treatment options compared to traditional injectable therapies.

Catalym GmbH, established in Munich, Germany in 2016, is a biotechnology company dedicated to developing innovative immunotherapies for cancer patients. The company focuses on neutralizing GDF-15, a central regulator of the immune system in the tumor microenvironment, aiming to demonstrate clinical proof-of-concept across multiple solid tumor indications with its lead program CTL-002. Catalym's mission is to transform cancer patients' lives by engaging their own immune systems and improving treatment options.

ADCendo ApS is a biotech company focused on the development of innovative anti-cancer therapies, specifically through the creation of antibody-drug conjugates (ADCs). These conjugates are designed to target receptors that are overexpressed in various forms of cancer, addressing significant unmet medical needs in the treatment landscape. ADCendo's approach aims to enhance targeted therapy for patients suffering from conditions such as soft-tissue sarcoma, osteosarcoma, glioblastoma multiforme, and triple-negative breast cancer, among others. By developing new medicines that effectively target carcinomas—including breast, colon, pancreatic, prostate, ovarian, and renal cancers—ADCendo seeks to improve treatment outcomes for cancer patients.

Karius, Inc. is a life sciences company based in Redwood City, California, with an additional office in Menlo Park. Founded in 2014, Karius specializes in generating genomic insights for infectious diseases through its innovative Karius Test. This non-invasive blood test utilizes sequencing of microbial cell-free DNA to identify and quantify a wide range of pathogens, including bacteria, DNA viruses, fungi, and parasites. The Karius Test is particularly useful in the diagnosis of complicated pneumonia, infections in immunocompromised patients, and endocarditis, enabling clinicians to make rapid and informed treatment decisions. Karius operates a CLIA-certified and CAP-accredited laboratory, providing high-complexity clinical laboratory testing and offering services for pathogen biomarker detection aimed at biopharmaceutical companies. The company is dedicated to advancing the understanding and management of infectious diseases, striving for a future where these conditions pose less of a threat to human health.

Argá Medtech is a developer of an innovative cardiac ablation system specifically designed for the treatment of cardiac arrhythmias, including ventricular tachycardia. The company utilizes a proprietary coherent sine-burst electroporation technology that enhances power and depth during procedures. This advanced system features an innovative catheter design that eliminates the need for multiple exchanges, offering improved flexibility and efficiency in clinical settings. By streamlining the treatment process, Argá Medtech aims to enable healthcare professionals to achieve better therapeutic outcomes for patients suffering from arrhythmias.

Mainstay Medical is a global medical device company based in Dublin, Ireland, with additional operations in the United States and Australia. The company specializes in developing innovative therapies for individuals suffering from chronic low back pain, a condition that affects a significant underserved population. Mainstay Medical has created an FDA-approved restorative treatment designed to enhance muscle control and improve functionality in the lumbar spine. This therapy aims to help patients regain mobility and enhance their overall quality of life. By collaborating with scientists and clinical experts, Mainstay Medical is committed to advancing solutions for those affected by debilitating back pain.

Nalu Medical is an early-stage company based in Carlsbad, California, focused on developing innovative medical devices to enhance the treatment of chronic pain. Founded in 2014, the company has created a battery-free, micro-implantable pulse generator that is cleared by the FDA for both Spinal Cord Stimulation (SCS) and Peripheral Nerve Stimulation (PNS). Nalu Medical's neurostimulation devices leverage neuromodulation technology to offer a variety of therapeutic options aimed at alleviating chronic pain, thereby improving the quality of life for patients.

Manufacturer of surgical reusable and disposable instruments intended for international medical technology companies. The company specializes in the production of surgical precision hand instruments and providing modern workstations, precise tools and state-of-the-art machinery, thereby enabling medical technology industry to improved surgical outcomes and reduced costs.

Tagworks Pharmaceuticals is a privately held biotech company based in the Netherlands, established in 2011 as a spin-out from Philips Healthcare. The company focuses on developing innovative in vivo chemistry to enhance the effectiveness of cancer therapies and to facilitate novel companion diagnostics. Operating from the Radboud University Medical Center in Nijmegen, Tagworks specializes in antibody-based imaging and therapy technologies. Its proprietary approach allows for the selective chemical manipulation of tagged antibodies in vivo, which improves the efficacy of established methods like radioimmuno-imaging and antibody-drug conjugates. This technology enables medical professionals to conduct imaging with significantly reduced radiation exposure for patients.

ADCendo ApS is a biotech company focused on the development of innovative anti-cancer therapies, specifically through the creation of antibody-drug conjugates (ADCs). These conjugates are designed to target receptors that are overexpressed in various forms of cancer, addressing significant unmet medical needs in the treatment landscape. ADCendo's approach aims to enhance targeted therapy for patients suffering from conditions such as soft-tissue sarcoma, osteosarcoma, glioblastoma multiforme, and triple-negative breast cancer, among others. By developing new medicines that effectively target carcinomas—including breast, colon, pancreatic, prostate, ovarian, and renal cancers—ADCendo seeks to improve treatment outcomes for cancer patients.

GT Medical Technologies, Inc. is a medical device company based in Tempe, Arizona, dedicated to improving the lives of patients with brain tumors. Founded in 2017, the company has developed an innovative treatment approach through its flagship product, GammaTile, which combines a biocompatible, conformable collagen matrix with brachytherapy radiation seeds. This technology is designed to address the limitations of existing treatments for recurrent brain tumors, providing a bioresorbable solution that enhances treatment efficacy. GammaTile is protected by multiple patents and has the potential to benefit a significant patient population, with an estimated 176,000 patients diagnosed annually in the United States. To date, clinical trials at Barrow Neurological Institute have demonstrated promising outcomes, with significant clinical improvements observed in patients treated with this novel device.

Fire1 is a Dublin-based company dedicated to developing innovative therapeutic devices aimed at enhancing the quality of life for heart failure patients. The company has created a remote monitoring system that delivers real-time patient data and insights to healthcare providers. This technology facilitates the early detection of complications associated with heart failure, allowing for proactive interventions and ultimately leading to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to transform the management of heart failure and support better health management for patients.

Noema Pharma AG is a biotechnology company based in Basel, Switzerland, founded in 2019. The company focuses on developing innovative therapeutic products for orphan neurological disorders characterized by imbalanced neuronal networks. Its research and development efforts are dedicated to addressing disabling symptoms associated with conditions affecting the nervous system, such as Tuberous Sclerosis Complex, Trigeminal Neuralgia, and Tourette syndrome. By creating novel therapies, Noema Pharma aims to enhance the quality of life and improve patient outcomes for those suffering from these challenging disorders.

Shoulder Innovations, Inc. is a medical device company based in Holland, Michigan, specializing in orthopedic solutions for shoulder replacement surgery. Founded in 2009, the company has developed an advanced Total Shoulder Replacement System that features innovative inset glenoid fixation technology, addressing the critical issue of glenoid implant stability during shoulder arthroplasty. This technology not only enhances the robustness of the glenoid platform but also simplifies the surgical instrumentation, aiming to reduce operative time and costs. The company's products are marketed through distribution partners in the United States and are designed to improve patient outcomes by minimizing the risk of glenoid loosening, which is a leading cause of revision surgeries. By focusing on reliable fixation and simplified surgical techniques, Shoulder Innovations strives to enhance the efficacy and longevity of shoulder implants while potentially lowering overall healthcare costs.

Volta Medical is a technology company based in Marseille, France, founded in 2016, specializing in the development of artificial intelligence software for interventional cardiology. Its primary focus is on providing innovative solutions to assist cardiologists in the treatment of atrial fibrillation, the most common cardiac arrhythmia. The company’s flagship product, AIFib, integrates AI algorithms that analyze electrograms and guides mapping catheters during interventional procedures. This sophisticated software enhances the ability of interventional cardiologists to make informed decisions and carry out patient-specific strategies for cardiac ablation, thereby improving the overall efficacy of heart surgeries. Through its commitment to advancing healthcare technology, Volta Medical aims to transform cardiac care by utilizing cutting-edge AI approaches in therapeutic applications.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Chr. Diener is a contract manufacturer of customer-specific precision surgical instruments.

Ablative Solutions, Inc. is a clinical-stage medical device company that specializes in the development of catheters for treating hypertension. Founded in 2011 and headquartered in San Jose, California, with an additional office in Kalamazoo, Michigan, the company offers the Peregrine System. This catheter facilitates the minimally invasive delivery of diagnostic and therapeutic agents into the perivascular space surrounding peripheral blood vessels. Ablative Solutions aims to provide an effective and safe alternative to traditional surgical renal denervation, utilizing an infusion catheter that performs chemical renal denervation with alcohol as the neurolytic agent. This approach is designed to offer significant advantages over energy-based systems, particularly for patients with hypertension that is not well controlled.

Nalu Medical is an early-stage company based in Carlsbad, California, focused on developing innovative medical devices to enhance the treatment of chronic pain. Founded in 2014, the company has created a battery-free, micro-implantable pulse generator that is cleared by the FDA for both Spinal Cord Stimulation (SCS) and Peripheral Nerve Stimulation (PNS). Nalu Medical's neurostimulation devices leverage neuromodulation technology to offer a variety of therapeutic options aimed at alleviating chronic pain, thereby improving the quality of life for patients.

Splice Bio is a biotechnology company based in Barcelona, Spain, that specializes in developing innovative gene therapies using its proprietary intein platform technology. Founded in 2012, the company focuses on addressing the needs of patients suffering from incurable genetic diseases. Splice Bio's technology, originally developed in the Muir Lab at Princeton University, enhances the capabilities of traditional adeno-associated viruses (AAVs) by allowing for larger gene cargo delivery and targeting a broader range of tissues. This advancement aims to overcome existing limitations in gene therapy, making it a promising solution for treating complex genetic disorders. The company was formerly known as Proteodesign, S.L. before rebranding to Splice Bio in September 2020.

EUROPIN is a manufacturer specializing in medical needles, including pen cannulas, lancet needles, and specialized medical needles. The company primarily focuses on the development of injection systems for self-medication, particularly in the areas of diabetes management and hormone therapies. EUROPIN's products are designed to meet precise specifications concerning application, dimensions, bevel, and design, ensuring they align with the needs of the medical and pharmaceutical industries globally. By providing high-quality and innovative needle solutions, EUROPIN supports patients and healthcare professionals in the effective administration of treatments.

Big Health is a digital therapeutics company headquartered in London, United Kingdom, that specializes in developing and marketing innovative behavioral health programs. The company's flagship product, Sleepio, is a digital sleep improvement program that employs Cognitive Behavioral Therapy techniques to address and personalize sleep disorders. By offering a fully automated healthcare portal, Big Health delivers highly personalized digital therapeutics and behavioral programs aimed at tackling various mental health issues. Their approach combines medical consultation with user-friendly technology, enabling individuals to effectively manage and overcome sleep-related disorders in an efficient manner.

ProVerum Medical is a medtech company focused on developing innovative minimally invasive devices for the treatment of benign prostatic hyperplasia (BPH). The company's technology offers a safer and more patient-friendly alternative to traditional BPH treatments, allowing patients to receive care in either a doctor's office or an operating room. ProVerum's device is designed to address the symptoms of prostate enlargement, which can lead to difficulties in urination. By placing the device inside the urethra, it aims to restore normal urinary function, ultimately enabling healthcare providers to deliver effective treatment options for patients suffering from this condition.

Calypso Biotech SA is an immunotherapy biotechnology company based in Plan-les-Ouates, Switzerland, founded in 2013 as a spin-off from Merck Serono. The company specializes in the discovery and development of monoclonal antibodies aimed at treating immune pathologies and addressing significant unmet medical needs. Calypso Biotech focuses on innovative therapies for autoimmune diseases, particularly those affecting patients with severe gastrointestinal conditions such as gastric and pancreatic cancer. The company operates as a semi-virtual organization, leveraging a highly experienced management team with extensive expertise in drug development and a robust scientific network to enhance value for its investors through a portfolio of proprietary antibody candidates.

Spire Health, established in 2013 and headquartered in San Francisco, specializes in developing health-tracking devices and remote patient monitoring solutions. The company's core product is a wearable device that senses physical movement, position, and breathing patterns, providing insights into daily activities and mental state through a mobile application. Spire Health focuses on chronic respiratory disease management, offering solutions for conditions such as COPD, congestive heart failure, asthma, and sleep disorders. Their mission is to empower patients and physicians with useful, actionable data by harnessing the power of algorithms and sensors, thereby improving health outcomes.

Klifo is a consulting firm specializing in drug development, providing comprehensive support to biotech and pharmaceutical companies. The company facilitates the advancement of drug development projects through a range of expert services, including clinical research operations, clinical trial supply management, regulatory affairs, quality assurance, and pharmacovigilance. In addition, Klifo offers expertise in the development of pharmaceutical and biotech products as well as medical devices. By integrating multidisciplinary consulting and operational solutions, Klifo aims to help its partners maximize opportunities, mitigate risks, and drive innovation throughout the drug development process.

ADCendo ApS is a biotech company focused on the development of innovative anti-cancer therapies, specifically through the creation of antibody-drug conjugates (ADCs). These conjugates are designed to target receptors that are overexpressed in various forms of cancer, addressing significant unmet medical needs in the treatment landscape. ADCendo's approach aims to enhance targeted therapy for patients suffering from conditions such as soft-tissue sarcoma, osteosarcoma, glioblastoma multiforme, and triple-negative breast cancer, among others. By developing new medicines that effectively target carcinomas—including breast, colon, pancreatic, prostate, ovarian, and renal cancers—ADCendo seeks to improve treatment outcomes for cancer patients.

Acti-Med is a manufacturer specializing in medical technology, focusing on the development and production of high-quality cannulas and cannula systems for the medical and pharmaceutical industries. The company provides a range of services including product development, tool making, and the production of various medical components such as skin punches, curettes, and spinal cannulas. Acti-Med is dedicated to creating tailored, highly-regulated solutions for clients involved in oncology, pain therapy, pharmaceuticals, and veterinary medicine, ensuring that their products meet the stringent requirements of these specialized fields.

LUMICKS specializes in advanced technologies for studying biology and cancer at the single-molecule and single-cell levels. The company aims to bridge the gap between molecular structure and function, enabling researchers to gain insights into complex biological processes. LUMICKS' flagship products, the C-Trap Optical Tweezers and Fluorescence Microscopy, allow for real-time analysis of molecular interactions. Additionally, the z-Movi Cell Avidity Analyzer provides tools for measuring and selecting immune cells based on their interactions with target cells. By facilitating live measurement and imaging, LUMICKS' instruments support researchers in understanding the fundamental causes of diseases, including cancer, and contribute to drug optimization efforts.

Amphista Therapeutics Limited is a biopharmaceutical company founded in 2017 and located in Motherwell, United Kingdom. It specializes in developing targeted protein degradation technology aimed at creating innovative cancer therapeutics. The company focuses on harnessing the body's natural processes to selectively degrade and eliminate disease-causing proteins. By advancing next-generation therapeutics, Amphista seeks to improve treatment efficacy for various diseases, particularly cancer, by modulating the abundance of proteins responsible for disease progression. This strategic approach aims to enhance patient outcomes and contribute to the advancement of therapeutic options in oncology.

Volta Medical is a technology company based in Marseille, France, founded in 2016, specializing in the development of artificial intelligence software for interventional cardiology. Its primary focus is on providing innovative solutions to assist cardiologists in the treatment of atrial fibrillation, the most common cardiac arrhythmia. The company’s flagship product, AIFib, integrates AI algorithms that analyze electrograms and guides mapping catheters during interventional procedures. This sophisticated software enhances the ability of interventional cardiologists to make informed decisions and carry out patient-specific strategies for cardiac ablation, thereby improving the overall efficacy of heart surgeries. Through its commitment to advancing healthcare technology, Volta Medical aims to transform cardiac care by utilizing cutting-edge AI approaches in therapeutic applications.

Noema Pharma AG is a biotechnology company based in Basel, Switzerland, founded in 2019. The company focuses on developing innovative therapeutic products for orphan neurological disorders characterized by imbalanced neuronal networks. Its research and development efforts are dedicated to addressing disabling symptoms associated with conditions affecting the nervous system, such as Tuberous Sclerosis Complex, Trigeminal Neuralgia, and Tourette syndrome. By creating novel therapies, Noema Pharma aims to enhance the quality of life and improve patient outcomes for those suffering from these challenging disorders.

Lava Therapeutics B.V. is a biotechnology company based in Utrecht, the Netherlands, focused on innovative cancer treatments. Founded in 2016, it specializes in the development of proprietary bispecific antibodies that engage gamma-delta T cells, aiming to harness the immune system's power to target and destroy tumor cells. The company's platform creates next-generation γδ T cell engaging antibodies designed for both hematological and solid tumors, emphasizing safety, potency, and cost-effectiveness in its biopharmaceuticals. By combining immune recruiting and activating functionalities, Lava Therapeutics seeks to transform cancer therapy and improve patient outcomes.

Lumeon Ltd. is a digital health company based in London, United Kingdom, specializing in care pathway management solutions for the healthcare sector. Founded in 2005 and previously known as Qinec Ltd., Lumeon offers a cloud-based platform called Care Pathway Manager, which provides a comprehensive, real-time view of the patient journey from referral to outcome. The platform enables healthcare providers to unify clinical and administrative workflows, automate tasks, and deliver measurable care, addressing the underlying systems that drive healthcare transformation. Lumeon's clientele includes some of Europe's leading healthcare providers, such as BUPA and Nuffield Health, reflecting its position as a key player in the market. The company employs over 90 professionals dedicated to enhancing patient care through effective management and analysis of healthcare pathways.

Eargo, Inc. is a consumer-focused medical device company specializing in the design and sale of hearing aids for individuals with hearing loss in the United States. Founded in 2010 and headquartered in San Jose, California, Eargo offers innovative, rechargeable hearing aids that can be controlled via smartphone, enhancing user convenience. The company provides online hearing screenings and virtual support, eliminating the need for in-person consultations. By adopting a direct-to-consumer model, Eargo aims to make hearing aids more accessible and reduce the social stigma often associated with them. Its user-centric approach addresses the common challenges of traditional hearing aid adoption, including cost and accessibility, thereby improving the quality of life for those with hearing difficulties.

Withings is a developer of digital health and wellness smart devices aimed at empowering individuals to make informed health decisions. The company offers a diverse array of products, including smart scales that help users achieve fitness and weight goals, stylish activity trackers and hybrid smartwatches, and an advanced sleep-tracking mat. Additionally, Withings produces medically accurate devices for monitoring blood pressure and temperature, enabling users to track their health progress effectively. These devices facilitate data sharing with healthcare professionals, enhancing the overall management of personal health.

CVRx, Inc. is a medical device company headquartered in Minneapolis, Minnesota, that specializes in the development of implantable technologies for the treatment of high blood pressure and heart failure. Founded in 2000, the company has created Barostim NEO, a neuro-modulation therapy that activates the body's natural mechanisms to regulate blood pressure and address heart failure progression. This therapy utilizes an implantable system that is tailored to the individual needs of patients. CVRx also offers the Rheos platform, which includes an implantable pulse generator and carotid sinus leads designed to deliver therapeutic energy to the carotid arteries. With a focus on minimally invasive solutions, CVRx primarily serves patients and healthcare professionals in the United States and internationally, including markets in the United Kingdom, the Netherlands, Italy, and Germany.

Big Health is a digital therapeutics company headquartered in London, United Kingdom, that specializes in developing and marketing innovative behavioral health programs. The company's flagship product, Sleepio, is a digital sleep improvement program that employs Cognitive Behavioral Therapy techniques to address and personalize sleep disorders. By offering a fully automated healthcare portal, Big Health delivers highly personalized digital therapeutics and behavioral programs aimed at tackling various mental health issues. Their approach combines medical consultation with user-friendly technology, enabling individuals to effectively manage and overcome sleep-related disorders in an efficient manner.

AM Pharma B.V. is a biopharmaceutical company based in Bunnik, the Netherlands, focused on developing and commercializing novel therapeutics for inflammatory and infectious diseases. Established in 2000, the company specializes in pre-clinical and clinical development using endogenous proteins and peptides derived from the human body. Its key products include alkaline phosphatase, aimed at treating acute kidney injury and ulcerative colitis, and the immune response amplifying peptide hLF1-11, which targets drug-resistant hospital-acquired infections. AM Pharma is committed to providing innovative therapies that enhance patient quality of life by addressing critical medical needs.

Draupnir Bio is focused on developing innovative cholesterol-lowering medications that aim to prevent heart blood clots more effectively than existing treatments. The company leverages a platform technology that explores the glycome to create novel therapeutics through advanced techniques in array technology, protein chemistry, and carbohydrate chemistry. Draupnir Bio specializes in synthesizing, screening, and selecting potent heparan sulfate glycomimetic drug candidates that address cardiovascular, inflammatory, and infectious diseases. Additionally, the company is working on protein degraders that target extracellular disease proteins, which could potentially address a wide range of unmet therapeutic needs across various medical conditions, providing more convenient treatment options compared to traditional injectable therapies.

AM Pharma B.V. is a biopharmaceutical company based in Bunnik, the Netherlands, focused on developing and commercializing novel therapeutics for inflammatory and infectious diseases. Established in 2000, the company specializes in pre-clinical and clinical development using endogenous proteins and peptides derived from the human body. Its key products include alkaline phosphatase, aimed at treating acute kidney injury and ulcerative colitis, and the immune response amplifying peptide hLF1-11, which targets drug-resistant hospital-acquired infections. AM Pharma is committed to providing innovative therapies that enhance patient quality of life by addressing critical medical needs.

Sanifit Therapeutics S.A. is a clinical-stage biopharmaceutical company dedicated to developing treatments for progressive vascular calcification disorders. Its primary product, SNF472, is a novel small molecule aimed at treating calciphylaxis, a serious condition affecting patients undergoing dialysis. In addition to SNF472, the company's pipeline includes Lit-Control, a medical device designed to enhance the quality of life for patients with renal lithiasis through self-monitoring of urinary pH; ASB-01, an oral and dental health solution; SNF671, a food supplement for promoting bone health; and Phytech, an implant surface treatment that incorporates bioactive molecules. Founded in 2004 and headquartered in Palma de Mallorca, Spain, Sanifit also operates an office in San Diego, California, and has expanded its activities into Switzerland since its inception.

CVRx, Inc. is a medical device company headquartered in Minneapolis, Minnesota, that specializes in the development of implantable technologies for the treatment of high blood pressure and heart failure. Founded in 2000, the company has created Barostim NEO, a neuro-modulation therapy that activates the body's natural mechanisms to regulate blood pressure and address heart failure progression. This therapy utilizes an implantable system that is tailored to the individual needs of patients. CVRx also offers the Rheos platform, which includes an implantable pulse generator and carotid sinus leads designed to deliver therapeutic energy to the carotid arteries. With a focus on minimally invasive solutions, CVRx primarily serves patients and healthcare professionals in the United States and internationally, including markets in the United Kingdom, the Netherlands, Italy, and Germany.

Vesper Medical, Inc. is a medical device company based in Wayne, Pennsylvania, founded in 2016. The company specializes in the development of minimally invasive peripheral vascular products aimed at treating patients with deep venous disease. Its primary offering is the Vesper DUO Venous Stent System, designed specifically for venous stenting. This system features a unique combination of strength and flexibility to address the complex anatomical challenges encountered in the iliac and femoral veins. Vesper Medical is dedicated to creating safe, effective, and user-friendly products that enhance patient care and support healthcare providers in improving patient outcomes in venous treatment.

Eetgemak BV, established in 2006 and located in Katwijk, the Netherlands, specializes in the production of ready-made meals tailored for various sectors, including healthcare and education. The company offers a diverse range of chilled and frozen meal options, including regular, biological, vegetarian, and multicultural dishes, as well as specialized dietary meals. Its clientele consists of hospitals, nursing homes, residential care centers, home care organizations, schools, daycare centers, and catering establishments. Eetgemak’s products are designed to support the nutritional needs and well-being of patients and residents, ensuring that meals are both convenient and health-conscious.

Calypso Biotech SA is an immunotherapy biotechnology company based in Plan-les-Ouates, Switzerland, founded in 2013 as a spin-off from Merck Serono. The company specializes in the discovery and development of monoclonal antibodies aimed at treating immune pathologies and addressing significant unmet medical needs. Calypso Biotech focuses on innovative therapies for autoimmune diseases, particularly those affecting patients with severe gastrointestinal conditions such as gastric and pancreatic cancer. The company operates as a semi-virtual organization, leveraging a highly experienced management team with extensive expertise in drug development and a robust scientific network to enhance value for its investors through a portfolio of proprietary antibody candidates.

Ablative Solutions, Inc. is a clinical-stage medical device company that specializes in the development of catheters for treating hypertension. Founded in 2011 and headquartered in San Jose, California, with an additional office in Kalamazoo, Michigan, the company offers the Peregrine System. This catheter facilitates the minimally invasive delivery of diagnostic and therapeutic agents into the perivascular space surrounding peripheral blood vessels. Ablative Solutions aims to provide an effective and safe alternative to traditional surgical renal denervation, utilizing an infusion catheter that performs chemical renal denervation with alcohol as the neurolytic agent. This approach is designed to offer significant advantages over energy-based systems, particularly for patients with hypertension that is not well controlled.

Lumeon Ltd. is a digital health company based in London, United Kingdom, specializing in care pathway management solutions for the healthcare sector. Founded in 2005 and previously known as Qinec Ltd., Lumeon offers a cloud-based platform called Care Pathway Manager, which provides a comprehensive, real-time view of the patient journey from referral to outcome. The platform enables healthcare providers to unify clinical and administrative workflows, automate tasks, and deliver measurable care, addressing the underlying systems that drive healthcare transformation. Lumeon's clientele includes some of Europe's leading healthcare providers, such as BUPA and Nuffield Health, reflecting its position as a key player in the market. The company employs over 90 professionals dedicated to enhancing patient care through effective management and analysis of healthcare pathways.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Lava Therapeutics B.V. is a biotechnology company based in Utrecht, the Netherlands, focused on innovative cancer treatments. Founded in 2016, it specializes in the development of proprietary bispecific antibodies that engage gamma-delta T cells, aiming to harness the immune system's power to target and destroy tumor cells. The company's platform creates next-generation γδ T cell engaging antibodies designed for both hematological and solid tumors, emphasizing safety, potency, and cost-effectiveness in its biopharmaceuticals. By combining immune recruiting and activating functionalities, Lava Therapeutics seeks to transform cancer therapy and improve patient outcomes.

Axonics Modulation Technologies, Inc. is a medical technology company focused on the development and commercialization of sacral neuromodulation (SNM) systems, catering to both domestic and international markets. The company’s SNM systems are designed to address conditions such as overactive bladder, urinary urge incontinence, urinary urgency frequency, fecal incontinence, and non-obstructive urinary retention. Its innovative rechargeable SNM System delivers mild electrical pulses to the sacral nerve, aiming to restore normal communication between the brain and the bladder and bowel to alleviate associated symptoms. Originally incorporated as American Restorative Medicine, Inc. in 2012, the company rebranded as Axonics Modulation Technologies, Inc. in August 2013 and is headquartered in Irvine, California.

Inari Medical, Inc. is a commercial-stage medical device company based in Irvine, California, that specializes in developing innovative products for the treatment of venous diseases. Founded in 2011, the company's primary focus is on venous thromboembolism, which it addresses through two key devices: the ClotTriever and the FlowTriever. The ClotTriever is designed for the minimally invasive removal of blood clots from peripheral blood vessels, specifically targeting patients with deep vein thrombosis. Meanwhile, the FlowTriever system effectively treats pulmonary embolism by removing large clots from major blood vessels without the need for thrombolytic drugs. Inari Medical primarily generates its revenue from the United States while also reaching international markets.

Performation Healthcare Intelligence is a prominent provider of healthcare-specific business intelligence solutions in the Netherlands. The company specializes in software, data analysis, and advisory services aimed at helping healthcare organizations monitor costs, processes, and quality. With a dedicated team of over a hundred consultants and business intelligence experts, Performation enables its clients to make informed decisions that enhance the delivery of effective and high-quality care. By addressing healthcare-wide information challenges and integrating data into actionable insights, the company supports its clients in optimizing their operations and improving patient outcomes.

Fire1 is a Dublin-based company dedicated to developing innovative therapeutic devices aimed at enhancing the quality of life for heart failure patients. The company has created a remote monitoring system that delivers real-time patient data and insights to healthcare providers. This technology facilitates the early detection of complications associated with heart failure, allowing for proactive interventions and ultimately leading to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to transform the management of heart failure and support better health management for patients.

Axonics Modulation Technologies, Inc. is a medical technology company focused on the development and commercialization of sacral neuromodulation (SNM) systems, catering to both domestic and international markets. The company’s SNM systems are designed to address conditions such as overactive bladder, urinary urge incontinence, urinary urgency frequency, fecal incontinence, and non-obstructive urinary retention. Its innovative rechargeable SNM System delivers mild electrical pulses to the sacral nerve, aiming to restore normal communication between the brain and the bladder and bowel to alleviate associated symptoms. Originally incorporated as American Restorative Medicine, Inc. in 2012, the company rebranded as Axonics Modulation Technologies, Inc. in August 2013 and is headquartered in Irvine, California.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Breath Therapeutics GmbH, based in Munich, Germany, with an additional office in Menlo Park, California, specializes in developing innovative drug-aerosol therapeutics aimed at treating bronchiolitis obliterans syndrome and other severe respiratory diseases. Founded in 2016 and operating as a subsidiary of Zambon S.p.A., the company focuses on creating novel formulations of existing drugs combined with advanced inhalation technologies. Their drug-device combinations are designed to deliver high concentrations of therapeutics directly to the lungs, enhancing efficacy while minimizing systemic exposure. This approach targets rare respiratory diseases with significant unmet medical needs, positioning Breath Therapeutics at the forefront of inhalation therapy advancements.

LUMICKS specializes in advanced technologies for studying biology and cancer at the single-molecule and single-cell levels. The company aims to bridge the gap between molecular structure and function, enabling researchers to gain insights into complex biological processes. LUMICKS' flagship products, the C-Trap Optical Tweezers and Fluorescence Microscopy, allow for real-time analysis of molecular interactions. Additionally, the z-Movi Cell Avidity Analyzer provides tools for measuring and selecting immune cells based on their interactions with target cells. By facilitating live measurement and imaging, LUMICKS' instruments support researchers in understanding the fundamental causes of diseases, including cancer, and contribute to drug optimization efforts.

Nyxoah S.A. is a health-technology company based in Mont-Saint-Guibert, Belgium, established in 2009. The company specializes in developing and commercializing innovative solutions for treating sleep disordered breathing conditions, particularly moderate to severe obstructive sleep apnea (OSA). Nyxoah's primary product, the Genio system, is a CE-Mark validated bilateral neurostimulation therapy designed to address OSA, which is recognized as the most prevalent sleep disordered breathing condition. OSA is linked to various health risks, including increased mortality and comorbidities such as cardiovascular diseases, depression, and stroke. The Genio system emphasizes user-centered design and represents a next-generation approach to treating this critical health issue.

NightBalance B.V., established in 2009, is a medical technology company that develops innovative solutions to improve sleep quality. Originating from research at Delft University of Technology, the company specializes in creating a smart therapy device designed to treat positional obstructive sleep apnea. This medical device, the Sleep Position Trainer, measures a patient's sleep behavior and prevents apnea episodes, allowing users to achieve more comfortable and restful sleep.

STAT-Diagnostica is a company dedicated to the development of near-patient testing products aimed at enhancing healthcare delivery. It specializes in creating point-of-care diagnostic devices designed for rapid turnaround applications and critical care environments. The company's flagship product, DiagCORE, is a portable multi-analyte instrument that supports both molecular and immunoassay testing across various clinical settings. By integrating multiple testing techniques into a single device, STAT-Diagnostica enables healthcare professionals to streamline patient care and improve diagnostic efficiency.

NIZO food research BV is an independent contract research organization based in Ede, the Netherlands, with additional offices in the United States, France, and Japan. Founded in 1948, NIZO specializes in providing research and innovation services to the dairy, food and beverage, ingredients, and biotech industries. The company focuses on developing new flavors and textures, utilizing advanced technologies to enhance food products while addressing sustainability, cost-effectiveness, and speed to market. NIZO's offerings include analysis, contract research, production services, webinars, white papers, training programs, and pre-competitive research. The company also operates a food-grade processing plant to bring innovative food technologies to life.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

BionX Medical Technologies specializes in manufacturing advanced prosthetic devices aimed at enhancing the mobility and quality of life for individuals with amputations. The company's flagship product, the BiOM Ankle, features powered propulsion that allows for more natural movement by simulating human-like gait mechanics. This innovative prosthesis utilizes sophisticated microprocessors and environmental sensors to continuously assess and adjust its performance, providing users with the ability to navigate various terrains, including slopes and stairs, with reduced energy expenditure. BionX Medical Technologies serves its clientele through a network of prosthetists and healthcare providers, both in the United States and internationally. Founded in 2007 and headquartered in Bedford, Massachusetts, the company transitioned from its former name, iWalk, Inc., in 2015 and is currently a subsidiary of Otto Bock HealthCare GmbH.

Sanifit Therapeutics S.A. is a clinical-stage biopharmaceutical company dedicated to developing treatments for progressive vascular calcification disorders. Its primary product, SNF472, is a novel small molecule aimed at treating calciphylaxis, a serious condition affecting patients undergoing dialysis. In addition to SNF472, the company's pipeline includes Lit-Control, a medical device designed to enhance the quality of life for patients with renal lithiasis through self-monitoring of urinary pH; ASB-01, an oral and dental health solution; SNF671, a food supplement for promoting bone health; and Phytech, an implant surface treatment that incorporates bioactive molecules. Founded in 2004 and headquartered in Palma de Mallorca, Spain, Sanifit also operates an office in San Diego, California, and has expanded its activities into Switzerland since its inception.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Zetacom is a systems integrator specializing in communication, network, and security solutions tailored for the corporate and healthcare sectors. The company provides comprehensive services to healthcare institutions, semi-government bodies, corporations, and small to medium enterprises (SMEs). Zetacom's offerings include the installation and maintenance of network infrastructures, telecommunication systems, and speech and data integration solutions. Additionally, the company supports DSL applications, contact centers, voice-over IP systems, and network security services. By focusing on reliable, cost-effective, and flexible solutions, Zetacom aims to enhance the communication capabilities of its clients across various industries.

Zetacom is a systems integrator specializing in communication, network, and security solutions tailored for the corporate and healthcare sectors. The company provides comprehensive services to healthcare institutions, semi-government bodies, corporations, and small to medium enterprises (SMEs). Zetacom's offerings include the installation and maintenance of network infrastructures, telecommunication systems, and speech and data integration solutions. Additionally, the company supports DSL applications, contact centers, voice-over IP systems, and network security services. By focusing on reliable, cost-effective, and flexible solutions, Zetacom aims to enhance the communication capabilities of its clients across various industries.

Lumeon Ltd. is a digital health company based in London, United Kingdom, specializing in care pathway management solutions for the healthcare sector. Founded in 2005 and previously known as Qinec Ltd., Lumeon offers a cloud-based platform called Care Pathway Manager, which provides a comprehensive, real-time view of the patient journey from referral to outcome. The platform enables healthcare providers to unify clinical and administrative workflows, automate tasks, and deliver measurable care, addressing the underlying systems that drive healthcare transformation. Lumeon's clientele includes some of Europe's leading healthcare providers, such as BUPA and Nuffield Health, reflecting its position as a key player in the market. The company employs over 90 professionals dedicated to enhancing patient care through effective management and analysis of healthcare pathways.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Novicare is a healthcare provider that specializes in delivering high-quality treatment services to nursing homes and individuals requiring home care. The company focuses on complex and chronic conditions, utilizing multidisciplinary self-managed teams to enhance the quality of (para) medical care. Novicare employs a diverse range of healthcare professionals, including geriatricians, psychologists, physiotherapists, occupational therapists, speech therapists, and dieticians, to address the varied needs of its clients. In addition to providing direct care, Novicare offers educational programs, interim management, and consultancy services to nursing homes, ensuring transparency and a strong commitment to patient involvement. Under its brand VitaalThuis, Novicare also extends its services to individuals receiving care at home, linking effective treatment with the actual needs of patients, particularly the elderly and those with intellectual disabilities.

AM Pharma B.V. is a biopharmaceutical company based in Bunnik, the Netherlands, focused on developing and commercializing novel therapeutics for inflammatory and infectious diseases. Established in 2000, the company specializes in pre-clinical and clinical development using endogenous proteins and peptides derived from the human body. Its key products include alkaline phosphatase, aimed at treating acute kidney injury and ulcerative colitis, and the immune response amplifying peptide hLF1-11, which targets drug-resistant hospital-acquired infections. AM Pharma is committed to providing innovative therapies that enhance patient quality of life by addressing critical medical needs.

Definiens is a provider of image analysis and data mining solutions specifically designed for quantitative digital pathology within the life sciences, diagnostic biomarkers, and healthcare sectors. The company's software delivers detailed insights from whole tissue slides, cell-based assays, and full body scans, enabling the integration of this information with data from various sources. By automating analysis workflows, Definiens enhances the capabilities of pharmaceutical and biotechnology companies, research institutions, clinical service organizations, and pathologists, facilitating informed decision-making in research, diagnostics, and therapy. Headquartered in Munich, Germany, with additional offices in the United States, Definiens aims to advance research, contribute to the development of personalized medicine, and improve patient outcomes.

Vapotherm, Inc. is a medical technology company specializing in the development and commercialization of proprietary Hi-VNI technology products designed to treat patients of all ages experiencing respiratory distress. Headquartered in Exeter, New Hampshire, the company offers a range of precision flow systems, including Precision Flow Hi-VNI, Precision Flow Plus, Precision Flow Classic, and Precision Flow Heliox, which deliver heated, humidified, and oxygenated air at high velocity through a small-bore nasal interface. Vapotherm also provides various companion products, such as the Vapotherm Transfer Unit for patient mobility, the Q50 compressor for compressed air, and aerosol solutions for medication delivery. Additionally, the company offers disposable products, including single-use nasal interfaces and Oxygen Assist Modules to help clinicians maintain target oxygen levels. Vapotherm generates revenue primarily through direct sales to hospitals in the United States and through distributors in select international markets. Founded in 1993, the company is committed to enhancing clinical outcomes and improving the quality of life for patients.

Viroclinics Biosciences is a prominent contract research and clinical laboratory service provider specializing in virology. The company focuses on diagnostic and preclinical studies, as well as drug development aimed at preventing and treating viral infections, particularly respiratory viruses like influenza. Viroclinics offers an extensive range of virology services that support both new drug development programs and post-marketing surveillance of existing drugs and vaccines. Their capabilities include traditional virology assays and advanced deep sequencing protocols applicable to a wide variety of viruses. Operating BSL2 and BSL3 laboratories, Viroclinics conducts analyses in compliance with international ISO 15189 accreditation standards. The company collaborates closely with the Erasmus MC Viroscience lab, enhancing its expertise in developing antivirals and vaccines while serving the biopharmaceutical community with tailored models for preclinical drug testing and expert guidance.

Sapiens Steering Brain Stimulation GmbH is a medical device company focused on advancing deep brain stimulation (DBS) therapy. Founded in 2011 as a spin-out of Royal Philips Electronics, Sapiens operates from offices in Eindhoven, the Netherlands, and Munich, Germany. The company is dedicated to developing a high-resolution, MRI-compatible DBS system designed to enhance patient comfort and improve therapeutic outcomes, particularly for individuals with Parkinson's disease. Sapiens’ innovative approach includes a unique steering brain stimulation system and image-guided programming, both of which are based on patented technologies.

Acacia Pharma Group plc, established in 2007, is a UK-based hospital pharmaceutical company specializing in the discovery, development, and commercialization of products for patients undergoing surgery, invasive procedures, or cancer chemotherapy. Its primary focus is on treating and preventing post-operative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV). Acacia Pharma's lead product, BARHEMSYS, is an intravenous amisulpride for PONV treatment and prophylaxis. Other key products include APD403, an intravenous and oral amisulpride for CINV, and BYFAVO, an ultra-short-acting intravenous benzodiazepine sedative/anesthetic for use in invasive medical procedures. These products primarily serve anesthesiologists and oncologists.

Pharmaline is an innovative semi-industrial compounding pharmacy located in Oldenzaal, Netherlands. Established in 2009 with 30 employees, the company has grown to over 140 staff members, all operating under the latest Good Manufacturing Practice (GMP) guidelines. Pharmaline provides a comprehensive range of pharmaceutical solutions, serving approximately 700 pharmacists across the Netherlands. The company focuses on standardization and rationalization to enhance the quality of care while reducing healthcare costs. Its offerings include both stock preparations and ad hoc preparations tailored to patient needs, encompassing creams, ointments, tablets, capsules, drops, liquids, suspensions, and injectables. Pharmaline aims to be a one-stop solution for pharmacy preparations, ensuring that pharmacists have easy access to necessary products. The company employs experienced pharmacists who provide expert advice on various aspects of pharmacotherapy, production engineering, application engineering, and legislation, all supported by modern equipment.

Definiens is a provider of image analysis and data mining solutions specifically designed for quantitative digital pathology within the life sciences, diagnostic biomarkers, and healthcare sectors. The company's software delivers detailed insights from whole tissue slides, cell-based assays, and full body scans, enabling the integration of this information with data from various sources. By automating analysis workflows, Definiens enhances the capabilities of pharmaceutical and biotechnology companies, research institutions, clinical service organizations, and pathologists, facilitating informed decision-making in research, diagnostics, and therapy. Headquartered in Munich, Germany, with additional offices in the United States, Definiens aims to advance research, contribute to the development of personalized medicine, and improve patient outcomes.

BionX Medical Technologies specializes in manufacturing advanced prosthetic devices aimed at enhancing the mobility and quality of life for individuals with amputations. The company's flagship product, the BiOM Ankle, features powered propulsion that allows for more natural movement by simulating human-like gait mechanics. This innovative prosthesis utilizes sophisticated microprocessors and environmental sensors to continuously assess and adjust its performance, providing users with the ability to navigate various terrains, including slopes and stairs, with reduced energy expenditure. BionX Medical Technologies serves its clientele through a network of prosthetists and healthcare providers, both in the United States and internationally. Founded in 2007 and headquartered in Bedford, Massachusetts, the company transitioned from its former name, iWalk, Inc., in 2015 and is currently a subsidiary of Otto Bock HealthCare GmbH.

Santaris Pharma A/S is a privately held clinical-stage biopharmaceutical company based in Denmark, specializing in the discovery and development of RNA-targeted therapies. Utilizing its proprietary Locked Nucleic Acid (LNA) Drug Platform and Drug Discovery Engine, the company focuses on delivering potent single-stranded LNA-based drug candidates for various disease states. Santaris Pharma's research and development efforts primarily target infectious diseases and cardiometabolic disorders, while also engaging in partnerships with major pharmaceutical companies to address a broader range of therapeutic areas, including cancer, cardiovascular disease, and rare genetic disorders. Founded in 2003, the company holds exclusive worldwide rights for the manufacture and sale of products containing LNA as an active ingredient, supporting its goal of obtaining marketing approval for its innovative therapies.

Agendia, Inc., established in 2003 and headquartered in Irvine, California, specializes in developing and distributing genomic-based diagnostic kits for cancer patients. The company's molecular diagnostic technology analyzes the complete human genome to provide physicians with crucial information about a patient's cancer, enabling personalized treatment plans. Agendia's breast cancer tests, for instance, help assess individual risk for metastasis and guide decisions on chemotherapy, hormonal therapy, or alternative treatments, thereby improving patient outcomes and reducing healthcare costs.

Prosonix Ltd. is a specialty pharmaceutical company based in Oxford, United Kingdom, focused on developing and marketing inhaled respiratory medicines for conditions such as asthma and chronic obstructive pulmonary disease. Established in 2006, Prosonix specializes in generic mono and combination therapies that utilize inhaled corticosteroids, long-acting beta agonists, and long-acting muscarinic antagonists. The company employs proprietary ultrasonic particle engineering technologies to create and optimize drug formulations, enhancing the delivery and effectiveness of its inhaled medications. Prosonix is recognized for its innovative approach to developing new methods for transforming molecules into particles suitable for inhalation, allowing for tailored therapeutic solutions. As of June 2015, Prosonix operates as a subsidiary of Circassia Limited.

Moximed, Inc. is a medical technology company based in Hayward, California, that focuses on developing innovative treatments for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain associated with medial compartment knee osteoarthritis, allowing patients to maintain high levels of activity. Additionally, Moximed has developed the MISHA Knee System, which provides an outpatient treatment option for individuals who have not responded to conventional therapies and are not suitable candidates for knee replacement surgery. By minimizing joint pain and providing dynamic load reduction, Moximed's implants aim to improve the standard of care and enhance the quality of life for patients, potentially delaying or avoiding the need for more invasive surgical interventions. Moximed has been operational since its incorporation in 2006, serving patients and medical professionals globally.

Inova Labs, Inc. is a medical device development and manufacturing company based in Austin, Texas. Established in 2002, it specializes in creating innovative products for direct patient care, particularly focusing on oxygen delivery solutions for individuals with respiratory conditions. The company’s flagship products include the LifeChoice stationary and portable oxygen concentrators, which utilize a pulse mode system to provide varying levels of supplemental oxygen. Inova Labs also offers a range of accessories, such as carrying cases, external batteries, and power adapters. These products are distributed through authorized providers, primarily via their online platforms, ensuring accessibility for patients in need of oxygen therapy.

Fysius Rugexperts is a leading chain of clinics in the Netherlands that specializes in treating lower-back and related pains. Utilizing the latest scientific insights, Fysius employs advanced treatment methods and aids, including the OriGENE device, to address chronic back and spinal pain. With a strong focus on patient care, the clinic treats over 10,000 patients annually, making it the largest and most specialized facility for back pain in the country. Fysius aims to help individuals maintain their health and fitness by effectively addressing spine-related issues.

ProFibrix B.V. is a biotechnology company focused on developing and marketing innovative products for the hemostasis and regenerative medicine sectors. Founded in 2004, the company specializes in Fibrocaps, a dry powder topical hemostat and tissue sealant designed to effectively control acute and severe bleeding during surgical procedures or due to traumatic injuries. Fibrocaps is formulated from a blend of fibrinogen and thrombin, two key proteins vital for blood clotting and tissue repair. Additionally, ProFibrix offers a sterilized single-use delivery device that facilitates the application of Fibrocaps to targeted areas, minimizing the need to manipulate the wound in a surgical setting. The company's products leverage human fibrinogen, a natural blood protein, to enhance hemostatic efficacy and promote healing.

VerzuimVitaal B.V. is a Dutch company that specializes in providing occupational health services aimed at managing employee absenteeism. Founded in 2011 and located in Woerden, the Netherlands, the company focuses on enhancing the vitality of organizations and their employees to reduce absenteeism costs. In addition to promoting employee wellness, VerzuimVitaal oversees the management of sick leave and the reintegration process for employees returning to work.

Prosonix Ltd. is a specialty pharmaceutical company based in Oxford, United Kingdom, focused on developing and marketing inhaled respiratory medicines for conditions such as asthma and chronic obstructive pulmonary disease. Established in 2006, Prosonix specializes in generic mono and combination therapies that utilize inhaled corticosteroids, long-acting beta agonists, and long-acting muscarinic antagonists. The company employs proprietary ultrasonic particle engineering technologies to create and optimize drug formulations, enhancing the delivery and effectiveness of its inhaled medications. Prosonix is recognized for its innovative approach to developing new methods for transforming molecules into particles suitable for inhalation, allowing for tailored therapeutic solutions. As of June 2015, Prosonix operates as a subsidiary of Circassia Limited.

Acacia Pharma Group plc, established in 2007, is a UK-based hospital pharmaceutical company specializing in the discovery, development, and commercialization of products for patients undergoing surgery, invasive procedures, or cancer chemotherapy. Its primary focus is on treating and preventing post-operative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV). Acacia Pharma's lead product, BARHEMSYS, is an intravenous amisulpride for PONV treatment and prophylaxis. Other key products include APD403, an intravenous and oral amisulpride for CINV, and BYFAVO, an ultra-short-acting intravenous benzodiazepine sedative/anesthetic for use in invasive medical procedures. These products primarily serve anesthesiologists and oncologists.