Next Level Ventures is a Des Moines, Iowa-based venture capital firm founded in 2013. It specializes in seed through growth-stage investments in United States-based companies across sectors including ag/bio, agriculture technology, manufacturing, information technology, health tech, fintech, AI/ML, SaaS, and other tech-enabled sectors. The firm typically makes minority investments ranging from $0.5 million to $5 million, with the potential for larger transactions via investment partners. It aims for a two-to-five-year holding period and commonly takes board seats on portfolio companies. Next Level Ventures operates as an investment adviser and supports entrepreneurs with capital, strategic guidance, and governance expertise.

Established in Ames, Iowa in 2015, Ag Startup Engine is a venture capital firm focused on investing in early-stage agricultural technology startups. It aims to bridge the gap in seed stage investment and mentorship for entrepreneurs in Iowa and the broader Midwest region.

Innova Memphis is a Tennessee-based venture capital firm established in 2007 by the Memphis Bioworks Foundation. It focuses on biosciences, technology, and agri-tech companies at pre-seed, seed, early-stage, and high-growth stages across the United States. The firm provides funding and hands-on support to help early ideas evolve into viable business units and aims to connect portfolio companies with established corporations for licensing, acquisitions, or follow-on investments. By combining technical know-how, market expertise, and venture capital, Innova Memphis seeks to accelerate product development and help startups reach milestones and scale toward market leadership.

Linseed Capital is an angel investment firm founded in 2005 and based in Omaha, Nebraska. It focuses on investing in startups primarily within the Midwest region of the United States.

UnityPoint Health Ventures is the corporate venture capital arm of UnityPoint Health, founded in 2019 and based in West Des Moines, Iowa. It invests in early-stage companies across healthcare, digital therapeutics, health information technology, tech-enabled services, medical devices, and diagnostics to support ideas and partnerships that improve the patient and provider experience and align with UnityPoint Health's mission.

Prairie Crest Capital is a Des Moines, Iowa-based venture capital firm focused on early-stage investments in agriculture technology and related technology innovations. Founded in 2016, the firm targets seed and Series A rounds across the United States. It leverages financial and operating experience to identify untapped opportunities and provides funding and development assistance to qualifying enterprises poised for accelerated growth.

Founded in 1998, Ag Ventures Alliance is a company that provides business support services tailored to the agriculture sector. It focuses on investing in seed-stage and early-stage companies within the agriculture and technology sectors based in the United States.

Twelve19 Ventures is a venture capital firm founded in 2014 and based in Des Moines, Iowa. It makes angel, seed, and venture investments in early stage and growth companies across consumer and enterprise sectors, supporting strong entrepreneurs and management teams.

Founded in 2022 and based in Des Moines, Iowa, Innoventures Iowa is a venture capital firm focusing on investments in the information technology, advanced manufacturing, and life science sectors.

ManchesterStory Group is a West Des Moines, Iowa-based venture capital firm that focuses on early-to-growth-stage investments in InsurTech, FinTech, and HealthTech. The firm partners with innovative startups to accelerate growth, leveraging industry expertise and a broad network to bridge startups with established players in insurance, financial services, and healthcare. It pursues opportunities across the United States and emphasizes collaboration and sustainable value creation through strategic relationships with industry participants.

Founded in 2006, New Capital Fund is a venture capital firm based in Little Chute, Wisconsin. It focuses on investing in seed-stage to growth-stage companies across various sectors including business products/services, materials/resources, healthcare, information technology, advanced manufacturing, life sciences, and TMT.

S2G Ventures is a Chicago-based, multi-stage investment firm focused on fostering innovation across food and agriculture, oceans, and energy. Founded in 2014, it targets late-stage venture and growth investments and maintains a portfolio spanning seed, venture, and growth rounds. The firm backs entrepreneurs delivering market-driven solutions that transform food systems and related sectors, including ingredients, infrastructure and logistics, food safety technology, retail and consumer brands, as well as opportunities in ocean and energy domains. Its objective is to catalyze healthier, sustainable, and locally sourced food systems through investments that cover agricultural products, logistics, and consumer offerings.

Founded in 2010, SVG Ventures is a venture capital firm based in Silicon Valley. It focuses on investing in early-stage technology companies operating within the agrifood, supply chain, sustainability, and climate sectors.

Kudu Investment Management LLC is a private equity and venture capital firm established in 2015 and based in New York, New York. The firm specializes in providing risk-sharing capital to asset and wealth management firms, focusing on ownership transfer, partner liquidity, management buyouts, and acquisition and growth finance. Kudu offers solutions for managers seeking a capital event while maintaining their independence, primarily through minority-stake equity investments. As a Registered Investment Adviser, Kudu Investment Management aims to support the growth and sustainability of its clients in the asset management industry.

Ulu Ventures is a Palo Alto, California-based seed and early-stage venture capital firm that backs technology-driven startups across the United States. Founded in 2008, it focuses on internet-enabled consumer and business services and a broad range of sectors including EdTech, FinTech, healthcare, sustainability, enterprise IT, SaaS, IoT, digital media, mobile, agtech, and marketplaces. The firm emphasizes backing diverse entrepreneurial teams and typically engages in co-investments with other investors to pursue meaningful exits. It is described as the first Latina-led venture fund in Silicon Valley and is among the larger seed-focused vehicles in the region.

Great North Ventures is a venture capital firm based in Maple Grove, Minnesota, founded in 2017. The firm focuses on investing in entrepreneurs who leverage breakthrough technologies to transform industries that remain reliant on analog processes. Great North Ventures primarily targets disruptive technology companies across the United States, providing essential guidance, capital, and connections from seed stage to Series B. The firm is committed to identifying promising startups regardless of their geographic location, recognizing that innovative companies are emerging beyond traditional hubs like Silicon Valley. With a foundation built by successful founders, Great North Ventures emphasizes the importance of execution and the capability of their portfolio companies.

Finistere Ventures, established in 2005, is a global venture capital firm headquartered in San Diego, California, with additional offices in Menlo Park, Dublin, and Tel Aviv. The firm specializes in investing in early to growth-stage companies across life sciences, information technology, sustainability, and agricultural technology sectors. Its focus includes medical devices, diagnostics, and food, energy, and health-related technologies. Finistere invests between $0.35 million to $4.5 million, typically holding investments for five years. The firm operates globally, with a presence in the United States, Israel, Australia, New Zealand, and Latin America.

Evergreen Climate Innovations, originally known as Clean Energy Trust, is a nonprofit organization based in Chicago, Illinois, that focuses on providing catalytic capital and support to entrepreneurs and startups developing impactful climate technologies. Founded in 2010, Evergreen's mission is to foster innovation in the Greater Midwest by aligning philanthropic and corporate contributions through its 501vc® Investment Fund. This approach aims to deliver significant environmental, economic, and social impact. Over the past decade, Evergreen has successfully invested in numerous startups, achieving an impressive leverage of $41 raised for every $1 invested. The organization is dedicated to cultivating a robust ecosystem of investors, donors, and collaborators to advance climate solutions in the region.

Leaps by Bayer is the corporate venture capital arm of Bayer. Established in 2015 and headquartered in Leverkusen, Germany, it invests in life sciences, including healthcare, biotechnology, and agriculture. The firm seeks long-term, disruptive technologies and supports innovations with potential for significant societal impact.

Launchpad Digital Health is a venture capital firm based in Emeryville, California that partners with early-stage digital health entrepreneurs to build companies that improve care, reduce costs, and enhance patient convenience. It provides capital at seed stage up to $1 million and at A and B rounds up to $2–3 million, with a focus on healthy living, wellness, patient compliance, remote diagnostics and monitoring, electronic health and wellness records, data analytics and big data, and independent living support. The founders have funded and operated numerous healthcare and technology ventures over the past two decades.

Founded in 2019, Uncorrelated Ventures is a venture capital firm based in San Francisco. It focuses on investing in early-stage infrastructure software companies.

Optum is a healthcare services and innovation company dedicated to improving health outcomes. It offers a range of services including family medicine, mental health care, and specialized therapies for rare diseases. Optum also provides healthcare financial services and technology solutions to health plan providers.

Founded in 2016, Cabra.VC is a venture capital firm based in Limassol, Cyprus with additional offices in Moscow and Riga. It specializes in direct investments across growth stages, focusing on consumer, enterprise, technology, and software sectors, particularly SaaS, B2B, and subscription-based business models. The firm considers investments in India and the United States.

M25 is a Chicago-based venture capital firm established in 2015 by Victor Gutwein and Mike Asem, focused on funding pre-seed and seed-stage technology startups in the Midwest. The firm supports portfolio companies across multiple industries, with a regional footprint spanning 24 Midwest cities in 11 states. Since its inception, M25 has backed more than 90 early-stage tech startups, aiming to accelerate growth and strengthen the Midwest startup ecosystem.

Rabo Ventures is a venture capital firm based in Utrecht, Netherlands, focused on fast-growing clean technology companies and on the food and agriculture sector. It backs startups developing renewable energy, environmental solutions, and agricultural technology, helping them scale innovative technologies in these sectors.

Bunge Ventures is an investment arm focused on agribusiness and food technology innovations.

AXA Venture Partners is an independent global investment platform that targets high-growth technology companies across Europe and North America. It operates a multi-stage investment approach with four strategies—venture, early growth, growth, and a fund of funds—and manages a substantial asset base, reported as more than €2.5 billion. The firm has backed numerous technology companies and funds, with more than 60 technology companies and more than 60 funds in its portfolio, and it works closely with founders to help scale their businesses globally. The team maintains offices in San Francisco, New York, London, Paris, and Hong Kong to support portfolio companies and sourcing.

Battery Ventures is a technology-focused investment firm founded in 1983 and based in Boston, Massachusetts. It engages in venture capital and private equity investments in technology companies, with emphasis on software (including application and infrastructure software), IT infrastructure technologies, consumer internet and mobile services, industrial technologies, and life science tools. The firm seeks to back category-defining businesses with potential for scalable growth, often supporting companies through multiple stages and across select global regions.

OSF HealthCare is a not-for-profit Catholic health care system based in Peoria, Illinois, operating a multi-state network in Illinois and Michigan. It provides a wide range of services across hospitals, a medical group, primary and specialty care, behavioral health, and home care through affiliated entities. The system includes multiple acute care facilities and a physician network of more than 600 providers, supported by OSF Saint Francis organization and the OSF Healthcare Foundation. Guided by Catholic values such as justice, compassion, integrity, teamwork, and stewardship, it follows ethical principles in decision making and patient care. Established in 1877, it serves more than 2.5 million people in the communities it serves.

Founded in 2014, Builders VC is a San Francisco-based venture capital firm focused on early-stage investments. It specializes in sectors where technology intersects with new business models to modernize industries such as healthcare, agriculture, industrials, and real estate.

Fulcrum Global Capital is a venture capital firm based in Kansas City, Missouri. Founded in 2016, it focuses on investing in companies operating in agriculture, agtech, food production, food safety, food waste, and animal health.

8VC is a technology and life sciences investment firm that partners with founders to develop transformational technologies and create long-term value. Its activities span sectors such as healthcare, logistics, software, energy, manufacturing, enterprise IT, and life sciences, with a focus on supporting early-stage and growth opportunities in the United States and beyond.

Pioneer Fund is a San Francisco-based venture capital firm founded in 2017 that makes early-stage investments across a wide range of sectors, including consumer products and services, financial services, information technology, advanced manufacturing, blockchain, life sciences, gaming, artificial intelligence and machine learning, construction technology, education technology, fintech, agriculture technology, advertising technology, augmented reality, autonomous vehicles, legal technology, oncology, pet technology, real estate technology, ride-hailing, SaaS and supply chain technology. The firm benefits from a network of more than 420 Y Combinator alumni, enabling it to identify and support YC-backed startups.

Mutual Capital Partners, established in 2004, is a private equity firm headquartered in Westlake, Ohio. The company specializes in venture capital investments, focusing on medical device and healthcare IT companies across the United States. It typically leads or co-leads investments, providing not only capital but also strategic guidance and operational support to its portfolio companies. The firm works closely with its network of over 100 investors, leveraging their expertise for due diligence, customer introductions, and ongoing executive counsel.

Research Corporation Technologies is a venture capital firm based in Tucson, Arizona, founded in 1987. It focuses on investing in technology companies in the medical device, therapeutic, and biotechnology sectors.

White Star Capital is a global multi-stage technology investment firm and venture platform headquartered in New York, with a presence across North America, Europe and Asia. It backs exceptional entrepreneurs building ambitious, internationally scalable tech companies, helping portfolio founders scale their businesses from Series A onwards through its experience, networks and value-add support. The firm invests across software, information technology and digital assets, operating a core venture program and a dedicated digital asset strategy that backs crypto networks and blockchain-enabled businesses. Its offices span New York, London, Montreal, Toronto, Paris, Tokyo and Hong Kong, enabling it to partner with founders to expand internationally.

RRE Ventures is a New York-based venture capital firm founded in 1994 that focuses on early-stage technology and financial services companies. It typically invests in seed and Series A rounds, with participation in Series B in select cases, and supports a broad portfolio across sectors including artificial intelligence, climate, consumer tech, cryptocurrency, enterprise software, fintech, healthcare, media, real estate, robotics, and space. The firm pursues opportunities across the United States and Canada and maintains a registered investment adviser status. By backing innovative technology solutions and scalable business models, RRE Ventures aims to help early-stage companies grow to broader markets.

Commerce Ventures is a San Francisco-based venture capital firm that invests across early-stage and growth capital in commerce-related sectors, including mobile, payments, retail fintech, insureTech, and related software and services. The firm combines capital with strategic guidance to help portfolio companies scale their commerce innovations, drawing a network of entrepreneurs, senior executives, and corporate partners from its focus sectors. It pursues opportunities across North America, funding software, financial services, and retail technology companies that transform how consumers shop and transact.

Tiger Global Management is a New York based investment firm that manages public and private market strategies to pursue technology-driven growth opportunities worldwide. Founded in 2001 by Charles (Chase) Coleman, the firm invests in leading global companies across various industries, with a particular emphasis on technology-enabled growth. In public markets it employs long/short and growth strategies, while in private markets it targets opportunities from early to late stage. The firm operates globally, including the United States, China, India, Latin America, and Eastern Europe, and works with portfolio companies across their lifecycle to drive long-term value.

Founders Fund is a San Francisco-based venture capital firm that backs science and technology companies across multiple stages, from seed to late-stage. It pursues transformative technologies and follows a founder-friendly investment approach that provides substantial support with minimal interference. The firm invests in ventures solving difficult problems across sectors such as aerospace and transportation, artificial intelligence, advanced computing, energy, healthcare, biotechnology, cybersecurity, fintech, consumer internet, software, robotics, and related technology fields. It has backed notable companies early, including SpaceX, Palantir, and Facebook, reflecting a history of partnering with ambitious founders to scale breakthrough technologies.

Advantage Capital Partners is a United States‑based venture capital firm that provides growth equity, debt, and mezzanine financing to small and mid‑market companies, with a focus on underserved communities and state and local economic development. The firm invests across sectors including manufacturing, technology, business services, life sciences, and energy, and also supports real estate development projects with equity and debt. It typically makes initial investments ranging roughly from half a million to ten million in companies with modest sales, and may participate in larger follow‑on rounds or co‑invest with other firms. It uses senior debt, mezzanine debt, subordinated loans, and government‑guaranteed lending, and often pursues equity positions through preferred shares or convertible notes. Advantage Capital operates nationwide in the United States, with roots in New Orleans and offices in multiple states, and has backed thousands of jobs and housing projects as part of its mission to expand inclusive economic growth.

Established in November 2013, Cool Japan Fund is a public-private initiative aimed at fostering international demand for exceptional Japanese products and services. It achieves this by providing risk capital to businesses across various sectors such as media & content, food & services, fashion & lifestyle.

Established in 2016, Stanley Ventures is the corporate venture capital arm of Stanley Black & Decker. Based in Atlanta, Georgia, USA, it invests in innovative startups, focusing on sectors such as SaaS, electrification, autonomy, construction technology, and advanced materials. The firm offers industry expertise, supplier relationships, and access to customers.

Trimble is a technology solutions company that helps field and mobile workers in businesses and government become more productive by linking workflows and asset lifecycles with location-based technology. Its offerings span surveying, construction, agriculture, fleet and asset management, public safety and mapping, and combine positioning technologies such as GPS, lasers and optics with software tailored to user needs and wireless delivery to connect the field with back-office operations. Founded in 1978 and headquartered in Sunnyvale, California, Trimble operates through three reportable segments: Architects, Engineers, Construction and Owners (AECO); Field Systems; and Transportation and Logistics, delivering software and hardware solutions to construction, logistics and related industries.

iSelect Fund Management is a venture capital firm based in Saint Louis, Missouri that pursues early-stage and growth investments across the United States, Canada, Europe and other markets. The firm targets opportunities in healthcare, software, agriculture and life sciences, including areas such as plant sciences, seed genetics, sustainability, immunotherapy, personalized medicine, consumer health and food technology. It typically backs seed and Series A or B rounds and aims for multi-year investment horizons. While it maintains a broad geographic scope, it emphasizes sectors with global growth potential and supports startups positioned to address food, health and scientific innovation on a regional and international scale.

First Analysis is a Chicago-based private equity and venture capital firm founded in 1981 that concentrates on early-stage investments in the United States. Its sectors include technology and software, healthcare, services, and clean-tech/chemicals. The firm supports growth by working closely with management on strategy, recruitment, sales and marketing, and corporate development, and it generally makes lead investments or participates as a syndicate partner with typical checks of 3 to 10 million. It emphasizes in-depth industry research and aims to help portfolio companies become profitable leaders in large markets. The firm operates as a registered investment adviser.

HPS Investment Partners is a global investment firm focused on non-investment grade credit. Founded in 2007 and headquartered in New York, it operates with offices worldwide. The firm originated as a unit of Highbridge Capital Management, a subsidiary of J.P. Morgan Asset Management, and was acquired by its principals in 2016, with J.P. Morgan retaining the hedge fund strategies. HPS manages a broad set of capital-structure strategies, including syndicated leveraged loans, high-yield bonds, privately negotiated senior secured debt, mezzanine financing, asset-based leasing, and private equity, serving clients across industries such as insurance, healthcare, media, retail, logistics, and marine.

Mid-America Angels is a business angel group founded in 2006 and headquartered in Fairway, Kansas, with additional offices in Lenexa and Lawrence, Kansas. The organization focuses on funding start-up and early-stage companies primarily in the Kansas-Missouri region and within a 150-mile radius of Kansas City. It engages a network of accredited investors to identify and finance opportunities, typically participating in seed, Series A, and Series B funding rounds. Mid-America Angels aims to invest between $250,000 and $1,500,000 in promising ventures, and may consider investments outside its primary geographic area in collaboration with other angel networks or investment organizations. The group's structure allows it to leverage the collective knowledge, experience, and capital of its members to support the growth of emerging businesses.

Sante Ventures is a life sciences venture capital firm that invests exclusively in early-stage companies developing innovative medical technologies or healthcare delivery models. Founded in 2006, the firm focuses on backing startups at the forefront of life sciences to advance medical innovation.

Cultivian Sandbox Ventures is a Chicago-based venture capital firm established in 2008, specializing in investments in disruptive agriculture and food technology companies. The firm takes an active role in its portfolio, engaging as early investors and board members to shape company strategy, recruit key executives, and secure further capital. Cultivian Sandbox Ventures distinguishes itself by leveraging a robust network and strategic partnerships within the agriculture and food sectors, providing substantial value beyond mere financial support. Its investment team, which combines expertise from Cultivian Ventures and Sandbox Industries, is proficient in sourcing, evaluating, and managing equity investments. This hands-on approach not only aims to build stronger businesses but also seeks to transform entire industries.