Novo Holdings

Supira Medical develops a percutaneous ventricular assist device (pVAD) designed to provide temporary mechanical support during high-risk coronary interventions and cardiogenic shock. Its solution assists the native pumping action of the heart, enabling patients to undergo necessary procedures.

Biocomposites is a medical device company based in Keele, United Kingdom, founded in 1996, that develops, manufactures and markets calcium-based bone repair products to regenerate and repair bone and soft tissue, offering calcium sulfate and calcium phosphate bone substitutes such as STIMULAN, geneX, and Allogran-R, along with synthetic calcium composite devices Bilok and Biosteon for interference screws and suture anchors used in musculoskeletal infection management, bone and joint trauma, spine procedures, and sports injuries; these products are designed to accelerate bone growth, improve implant integration, and support surgical outcomes in orthopedic and spinal procedures.

FIRE1 is an Irish-based company specializing in the development of innovative therapeutic devices. Its flagship product is a remote monitoring system designed to enhance heart failure patients' lives by providing real-time data to healthcare providers, facilitating early detection and proactive interventions.

Quanta is a medical devices company that develops advanced haemodialysis systems for use in the home and clinic. Quanta is focused on the commercialisation and ongoing development of SC+, an innovative cartridge-based haemodialysis system. SC+ is a high performance, compact haemodialysis system providing clinical efficacy by utilising typical flow rates of traditional in-centre machines. SC+ supports the entire ‘Continuum of Care’ for dialysis patients, from nurse-assisted treatment through self-care in centre to home haemodialysis. Their system facilitates the seamless transition between treatment modalities providing the best tool to enable flexibility for patients, and treatment options for physicians.

Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

Magenta Medical is a private medical device company based in Kadima, Israel, founded in 2012. It develops catheter-based therapies for acute decompensated heart failure, including a self-expanding heart pump and temporary venous catheter-based treatments designed to relieve renal venous congestion. The technology enables quicker and safer removal of excess fluid and salt while protecting renal function, addressing a core pathophysiological element of acute heart failure and related conditions.

CARGO Therapeutics is a clinical-stage biotechnology company developing next-generation CAR T-cell therapies to overcome cancer treatment resistance and access barriers. The company focuses on addressing limitations of approved autologous CAR T therapies, including manufacturing constraints, long turnaround times, and reimbursement challenges, to broaden patient access to potentially curative treatments. Its programs aim to deliver novel solutions that improve cancer treatment outcomes and patient experience. One of its product candidates, CRG-023, is a tri-specific CAR T designed to overcome relapse by targeting multiple B-cell antigens (CD19, CD20, CD22) and addressing mechanisms such as antigen loss, insufficient co-stimulation, and T cell exhaustion.

Nalu Medical is an early-stage company based in Carlsbad, California, focused on developing innovative medical devices to enhance the treatment of chronic pain. Founded in 2014, the company has created a battery-free, micro-implantable pulse generator that is cleared by the FDA for both Spinal Cord Stimulation (SCS) and Peripheral Nerve Stimulation (PNS). Nalu Medical's neurostimulation devices leverage neuromodulation technology to offer a variety of therapeutic options aimed at alleviating chronic pain, thereby improving the quality of life for patients.

FIRE1 is an Irish-based company specializing in the development of innovative therapeutic devices. Its flagship product is a remote monitoring system designed to enhance heart failure patients' lives by providing real-time data to healthcare providers, facilitating early detection and proactive interventions.

Evosep is a developer of clinical proteomics solutions focused on making protein analysis faster and more robust for clinical and large-scale studies. Its products include EVOSEP ONE, a separation tool for clinical omics, and EVOTIP, disposable trap columns for sample loading. The company aims to enable reproducible plasma performance, protein identification with short gradients, rapid generation of data-independent acquisition libraries, and scalable screening for biomarkers in large cohorts. Built on extensive nano-UHPLC R&D experience, Evosep designs system architectures that improve throughput while maintaining reliability for clinical diagnostics. Founded in 2016 and based in Odense, Denmark, Evosep collaborates with leading scientists to advance proteomics-driven diagnostics.

Precirix is a biotechnology company based in Brussels, Belgium, focused on the development of radio-immunotherapeutic drugs aimed at treating cancer patients. Established in 2014, the company utilizes the unique properties of the camelid immune system to create targeted therapies. Its innovative approach involves using antigen-binding fragments to deliver therapeutic radioisotopes directly to specific receptors on cancer cells. This method allows for a more personalized treatment option, enhancing the effectiveness of cancer therapies while minimizing damage to healthy tissue. Precirix is dedicated to advancing the field of oncology through its specialized drug development, contributing to improved outcomes for patients with various types of cancer.

Verana Health, Inc. is a digital health company based in San Francisco, California, that specializes in transforming healthcare data into actionable insights. Founded in 2008 and formerly known as Digisight Technologies, the company connects healthcare providers with patients through innovative solutions. Its flagship product, SightBook, is a mobile application that enables users to test their vision and share results with their physicians in real-time, facilitating timely appointments and treatments. Verana Health manages data from over 20,000 healthcare providers and 70 electronic health record systems, leveraging its AI-enhanced platform, VeraQ™, to create a robust healthcare data ecosystem. By utilizing advanced analytics on curated datasets, Verana Health supports life sciences partners in improving clinical research and enhancing patient care outcomes.

Inbrace is a medical device company focused on revolutionizing orthodontic treatment with its innovative device that aligns teeth discreetly behind the teeth. This system utilizes patented self-guiding technology to apply continuous forces, allowing for gentle teeth correction while minimizing discomfort and reducing the frequency of dental visits compared to traditional methods. Inbrace aims to enhance patient confidence and satisfaction by addressing common concerns associated with orthodontic treatment. The company incorporates digital treatment planning, computer modeling, and direct digital manufacturing to provide a scalable, personalized solution that meets the diverse needs of orthodontic patients. With its FDA registration, Inbrace is positioned to disrupt the orthodontics market and drive practice growth for dental clinicians.

Founded in 2001, Availity optimizes healthcare information exchange via an internet-based platform. It connects providers, health plans, and technology partners, facilitating administrative, financial, and clinical processes through real-time data sharing.

Quanta is a medical devices company that develops advanced haemodialysis systems for use in the home and clinic. Quanta is focused on the commercialisation and ongoing development of SC+, an innovative cartridge-based haemodialysis system. SC+ is a high performance, compact haemodialysis system providing clinical efficacy by utilising typical flow rates of traditional in-centre machines. SC+ supports the entire ‘Continuum of Care’ for dialysis patients, from nurse-assisted treatment through self-care in centre to home haemodialysis. Their system facilitates the seamless transition between treatment modalities providing the best tool to enable flexibility for patients, and treatment options for physicians.

CorWave is a company focused on developing innovative implanted cardiac support devices aimed at improving the quality of life for patients suffering from heart failure. Its flagship product, the CorWave LVAD, employs a unique undulating disc wave pumping mechanism, which replaces traditional high-speed impellers used in current continuous flow rotary pumps. This design significantly reduces trauma to blood, thereby minimizing complications such as clotting and bleeding. The CorWave pump generates a pulsatile flow that closely resembles the natural heartbeat, addressing a key limitation of existing LVADs that provide only continuous flow. Additionally, the device's low power consumption and compact size facilitate its potential for complete implantation, enhanced by a wireless energy transfer system. Through these advancements, CorWave aims to alleviate the burdens associated with heart failure and invasive surgical procedures.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Mission Bio develops and delivers tools for studying cellular heterogeneity in human health and life science research. Its flagship product is the Tapestri Platform, a single-cell platform that detects DNA and protein changes, enabling precise detection of heterogeneity in disease progression and treatment response. The company's solutions are primarily applied in oncology, including blood cancers and solid tumors.

Preventice Solutions, Inc., established in 2007, specializes in healthcare technology solutions. The company offers a range of services, sensors, and software to remotely monitor and manage patient health data, primarily focusing on cardiac care. Key products include the PatientCare Portal, a self-managed cloud platform for real-time patient data management; BodyGuardian Heart, a pocket-sized wearable monitor for enhanced patient mobility and compliance; and BodyGuardian Verité, a dual-modality remote cardiac sensor for physicians. Preventice Solutions operates from Eagan, Minnesota, with additional offices in Fargo, North Dakota, San Francisco, California, and Houston, Texas.

Reapplix is a Danish medical technology company that develops autologous wound therapy and tissue regeneration solutions derived from the patient's blood. It identifies and isolates blood-derived proteins to accelerate healing of chronic wounds and markets a device capable of delivering autologous active cell therapy to treat diabetic foot ulcers, with the aim of improving healing outcomes and reducing treatment costs. Founded in 2008 and based in Birkerod, Denmark, the company focuses on enabling hospitals to provide biological wound treatment using the patient's own cells.

Freeline Therapeutics is a clinical-stage biotechnology company specializing in systemic adeno-associated virus (AAV)-based gene therapies. Its pipeline includes FLT180a for hemophilia B, FLT190 for Fabry disease, FLT201 for type 1 Gaucher disease, and FLT210 for hemophilia A, all in various stages of clinical trials.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Aligos Therapeutics is a biopharmaceutical company dedicated to developing innovative therapeutics targeting viral infections and liver diseases. Founded in 2018, the company focuses on chronic hepatitis B (CHB) and non-alcoholic steatohepatitis (NASH), leveraging its expertise in liver disease drug development.

Clario specializes in endpoint technology solutions for clinical trials, serving pharmaceutical, biotech, and medical device partners. The company integrates scientific expertise with a comprehensive technology platform to facilitate various trial models, including decentralized, hybrid, and site-based studies. With a presence in nine countries and around 30 facilities across North America, Europe, and Asia Pacific, Clario has been providing critical clinical evidence for nearly 50 years. Its services include health outcomes research, cardiac safety, respiratory assessments, electronic clinical outcomes, and suicide risk evaluations. By leveraging software-enabled clinical research, Clario aims to enhance data quality, reduce costs, shorten study timelines, and improve trial oversight and patient engagement.

Reapplix is a Danish medical technology company that develops autologous wound therapy and tissue regeneration solutions derived from the patient's blood. It identifies and isolates blood-derived proteins to accelerate healing of chronic wounds and markets a device capable of delivering autologous active cell therapy to treat diabetic foot ulcers, with the aim of improving healing outcomes and reducing treatment costs. Founded in 2008 and based in Birkerod, Denmark, the company focuses on enabling hospitals to provide biological wound treatment using the patient's own cells.

Inbrace is a medical device company focused on revolutionizing orthodontic treatment with its innovative device that aligns teeth discreetly behind the teeth. This system utilizes patented self-guiding technology to apply continuous forces, allowing for gentle teeth correction while minimizing discomfort and reducing the frequency of dental visits compared to traditional methods. Inbrace aims to enhance patient confidence and satisfaction by addressing common concerns associated with orthodontic treatment. The company incorporates digital treatment planning, computer modeling, and direct digital manufacturing to provide a scalable, personalized solution that meets the diverse needs of orthodontic patients. With its FDA registration, Inbrace is positioned to disrupt the orthodontics market and drive practice growth for dental clinicians.

AFYX Therapeutics A/S is a pharmaceutical company based in Copenhagen, Denmark, focused on developing and manufacturing treatments for mucosal diseases. Established in 2014, the company is known for its flagship product, the Rivelin® patch, which is designed for the treatment of oral lichen planus. This innovative patch is flexible, biodegradable, and adheres to mucosal surfaces, utilizing electrospinning technology to deliver medication directly to the affected area. By offering targeted therapies for conditions that currently lack approved treatment options, AFYX Therapeutics aims to enhance patient relief and support recovery without disrupting daily activities.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Precirix is a biotechnology company based in Brussels, Belgium, focused on the development of radio-immunotherapeutic drugs aimed at treating cancer patients. Established in 2014, the company utilizes the unique properties of the camelid immune system to create targeted therapies. Its innovative approach involves using antigen-binding fragments to deliver therapeutic radioisotopes directly to specific receptors on cancer cells. This method allows for a more personalized treatment option, enhancing the effectiveness of cancer therapies while minimizing damage to healthy tissue. Precirix is dedicated to advancing the field of oncology through its specialized drug development, contributing to improved outcomes for patients with various types of cancer.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Therachon is a biotechnology company specializing in the development of treatments for rare genetic diseases that lack available therapies. Primarily based in Basel, Switzerland, with research labs in Nice, France, the company is advancing its lead candidate, TA-46, a novel protein therapy aimed at treating achondroplasia, the most prevalent form of short-limbed dwarfism. In addition to its focus on achondroplasia, Therachon is also committed to developing therapeutics targeting rare gastrointestinal and musculoskeletal disorders, with the goal of enabling medical professionals to effectively manage conditions such as short bowel syndrome.

Unchained Labs is a life sciences tools company based in Pleasanton, California, specializing in solutions for biologics and gene therapy researchers. Established in 2014, it develops a range of products designed to enhance the efficiency and effectiveness of research in protein stability and formulation. Key offerings include the Optim platform, which allows researchers to measure multiple protein stability parameters simultaneously, and GRUNT, an automated system for biologic formulation preparation. In addition to these, the company provides various tools such as protein sizing systems, stability quantifiers, and automated buffer exchange systems. Unchained Labs serves biopharma and academic customers globally, distributing its products through partnerships in Europe, North and South America, Japan, and other Asian markets.

Aligos Therapeutics is a biopharmaceutical company dedicated to developing innovative therapeutics targeting viral infections and liver diseases. Founded in 2018, the company focuses on chronic hepatitis B (CHB) and non-alcoholic steatohepatitis (NASH), leveraging its expertise in liver disease drug development.

Unchained Labs is a life sciences tools company based in Pleasanton, California, specializing in solutions for biologics and gene therapy researchers. Established in 2014, it develops a range of products designed to enhance the efficiency and effectiveness of research in protein stability and formulation. Key offerings include the Optim platform, which allows researchers to measure multiple protein stability parameters simultaneously, and GRUNT, an automated system for biologic formulation preparation. In addition to these, the company provides various tools such as protein sizing systems, stability quantifiers, and automated buffer exchange systems. Unchained Labs serves biopharma and academic customers globally, distributing its products through partnerships in Europe, North and South America, Japan, and other Asian markets.

AFYX Therapeutics A/S is a pharmaceutical company based in Copenhagen, Denmark, focused on developing and manufacturing treatments for mucosal diseases. Established in 2014, the company is known for its flagship product, the Rivelin® patch, which is designed for the treatment of oral lichen planus. This innovative patch is flexible, biodegradable, and adheres to mucosal surfaces, utilizing electrospinning technology to deliver medication directly to the affected area. By offering targeted therapies for conditions that currently lack approved treatment options, AFYX Therapeutics aims to enhance patient relief and support recovery without disrupting daily activities.

ConvaTec is a global medical technology company that develops and markets products and technologies for the management of chronic conditions, with focused offerings in advanced wound care, ostomy care, continence care, critical care, and infusion devices. The company serves patients and caregivers in both acute-care hospital and home settings, designing, manufacturing, and supplying medical products across wound care, ostomy, continence, and infusion device categories.

AMRA Medical is an international medical technology company that specializes in transforming magnetic resonance imaging (MRI) into precise body composition measurements through a cloud-based, computer-aided service. This innovative approach allows for the automatic generation of detailed biomarkers related to fat and muscle, enhancing the understanding of individual health profiles. By collaborating with leading pharmaceutical organizations, research institutions, and healthcare facilities, AMRA contributes significantly to metabolic research and the development of therapeutic applications. Its technology aids medical professionals in monitoring clinically relevant changes in body composition, ultimately supporting the prediction and prevention of various diseases. Through its advancements, AMRA Medical plays a vital role in evolving clinical care and medical research, offering valuable insights into genetics, lifestyle, and overall biology.

Minerva Surgical Inc. is a medical technology company based in Redwood City, California, dedicated to women's healthcare. Founded in 2008, the company specializes in developing, manufacturing, and commercializing minimally invasive solutions for uterine health. Its flagship product, the Minerva Endometrial Ablation System, is designed to treat abnormal uterine bleeding, a common issue affecting many women. Minerva Surgical offers a comprehensive range of alternatives to hysterectomy, aiming to address the underlying causes of abnormal uterine bleeding while preserving the uterus. These solutions are applicable in various medical environments and seek to overcome the limitations of traditional treatment methods, providing women with effective and less invasive options for their healthcare needs.

CorWave is a company focused on developing innovative implanted cardiac support devices aimed at improving the quality of life for patients suffering from heart failure. Its flagship product, the CorWave LVAD, employs a unique undulating disc wave pumping mechanism, which replaces traditional high-speed impellers used in current continuous flow rotary pumps. This design significantly reduces trauma to blood, thereby minimizing complications such as clotting and bleeding. The CorWave pump generates a pulsatile flow that closely resembles the natural heartbeat, addressing a key limitation of existing LVADs that provide only continuous flow. Additionally, the device's low power consumption and compact size facilitate its potential for complete implantation, enhanced by a wireless energy transfer system. Through these advancements, CorWave aims to alleviate the burdens associated with heart failure and invasive surgical procedures.

Reapplix is a Danish medical technology company that develops autologous wound therapy and tissue regeneration solutions derived from the patient's blood. It identifies and isolates blood-derived proteins to accelerate healing of chronic wounds and markets a device capable of delivering autologous active cell therapy to treat diabetic foot ulcers, with the aim of improving healing outcomes and reducing treatment costs. Founded in 2008 and based in Birkerod, Denmark, the company focuses on enabling hospitals to provide biological wound treatment using the patient's own cells.

Clario specializes in endpoint technology solutions for clinical trials, serving pharmaceutical, biotech, and medical device partners. The company integrates scientific expertise with a comprehensive technology platform to facilitate various trial models, including decentralized, hybrid, and site-based studies. With a presence in nine countries and around 30 facilities across North America, Europe, and Asia Pacific, Clario has been providing critical clinical evidence for nearly 50 years. Its services include health outcomes research, cardiac safety, respiratory assessments, electronic clinical outcomes, and suicide risk evaluations. By leveraging software-enabled clinical research, Clario aims to enhance data quality, reduce costs, shorten study timelines, and improve trial oversight and patient engagement.

The Spectranetics Corporation specializes in the development, manufacturing, and distribution of single-use medical devices for minimally invasive cardiovascular procedures. Its portfolio includes laser and aspiration catheters, scoring balloon catheters, and drug-coated balloon catheters, used to cross, prepare, and treat arterial blockages in the legs and heart. Additionally, the company offers products for the removal of pacemaker and defibrillator cardiac leads, and provides laser systems for various cardiovascular procedures. Spectranetics sells its products directly and through distributors worldwide, with a focus on innovation to meet the demands of complex cardiac lead removal and vascular intervention procedures. Headquartered in Colorado Springs, Colorado, the company operates as a subsidiary of Philips Holding USA Inc.

Unchained Labs is a life sciences tools company based in Pleasanton, California, specializing in solutions for biologics and gene therapy researchers. Established in 2014, it develops a range of products designed to enhance the efficiency and effectiveness of research in protein stability and formulation. Key offerings include the Optim platform, which allows researchers to measure multiple protein stability parameters simultaneously, and GRUNT, an automated system for biologic formulation preparation. In addition to these, the company provides various tools such as protein sizing systems, stability quantifiers, and automated buffer exchange systems. Unchained Labs serves biopharma and academic customers globally, distributing its products through partnerships in Europe, North and South America, Japan, and other Asian markets.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Galera Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutics to mitigate radiotherapy-induced side effects in cancer patients. Its lead product candidate, avasopasem manganese (GC4419), is a small molecule superoxide dismutase mimetic currently in Phase III trials for treating radiation-induced severe oral mucositis in head and neck cancer patients.

Cardeas Pharma is focused on developing an innovative antibiotic formulation that combines two drugs to target highly resistant Gram-negative bacilli, such as Pseudomonas aeruginosa and Acinetobacter baumannii, as well as carbapenem-resistant Enterobacteriaceae. This formulation is designed to treat serious respiratory infections in critical care settings, particularly those caused by antibiotic-resistant organisms. Additionally, it demonstrates efficacy against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), and has activity on biofilms. The delivery system utilizes a single-patient use, vibrating-plate nebulizer compatible with all ventilators, which generates small, uniform aerosol droplets that effectively reach the small airways and alveoli. By integrating this novel antibiotic formulation with advanced drug-delivery technology, Cardeas Pharma aims to achieve substantial clinical improvements over current treatment standards.

Unchained Labs is a life sciences tools company based in Pleasanton, California, specializing in solutions for biologics and gene therapy researchers. Established in 2014, it develops a range of products designed to enhance the efficiency and effectiveness of research in protein stability and formulation. Key offerings include the Optim platform, which allows researchers to measure multiple protein stability parameters simultaneously, and GRUNT, an automated system for biologic formulation preparation. In addition to these, the company provides various tools such as protein sizing systems, stability quantifiers, and automated buffer exchange systems. Unchained Labs serves biopharma and academic customers globally, distributing its products through partnerships in Europe, North and South America, Japan, and other Asian markets.

iRhythm Technologies is a digital healthcare company specializing in ambulatory cardiac monitoring solutions. It offers the Zio Patch, a wire-free, wearable biosensor that records ECG data for up to 14 days, aiding physicians in diagnosing arrhythmias efficiently.

Ceterix Orthopaedics, Inc. is a medical technology company that specializes in developing innovative surgical tools for arthroscopic procedures. Founded in October 2010 and based in Fremont, California, Ceterix offers the NovoStitch® Plus Meniscal Repair System, designed to address complex meniscal tears, including horizontal, radial, and root tears. The company also provides the Novocut Suture Manager, a device that facilitates efficient suture management. Ceterix's technology enables orthopedic surgeons to create intricate suture patterns in tight joint compartments while safeguarding surrounding structures, such as nerves and cartilage. This advancement allows for improved outcomes in arthroscopic procedures across various joints, including the knees, hips, and shoulders. Ceterix was previously known as SuturePro Technologies, Inc. before rebranding in April 2011 and is currently a subsidiary of Smith & Nephew plc.

SI-BONE, Inc. is a medical device company based in Santa Clara, California, that specializes in the development and commercialization of implantable devices for surgical treatment of sacropelvic anatomy. Founded in 2008, the company offers a range of patented titanium implants, including the iFuse system, which is designed for the minimally invasive fusion of the sacroiliac joint to alleviate dysfunction that leads to lower back pain. The iFuse implant procedure is noted for its reduced invasiveness and efficiency compared to traditional open fusion methods. In addition to the iFuse system, SI-BONE develops other products such as iFuse-3D, iFuse-TORQ, and iFuse Bedrock Granite, which address various conditions related to sacroiliac joint dysfunction, spinal deformity, and pelvic trauma. The company operates both in the United States and internationally.

Nevro Corporation is a global medical device company specializing in innovative solutions for chronic pain management. Its primary product is the Senza spinal cord stimulation (SCS) system, which employs proprietary HF10 therapy to deliver evidence-based neuromodulation treatment. The Senza system consists of implantable components controlled by patients and managed by healthcare professionals using specialized software. Nevro generates a significant portion of its revenue in the United States.

Cardeas Pharma is focused on developing an innovative antibiotic formulation that combines two drugs to target highly resistant Gram-negative bacilli, such as Pseudomonas aeruginosa and Acinetobacter baumannii, as well as carbapenem-resistant Enterobacteriaceae. This formulation is designed to treat serious respiratory infections in critical care settings, particularly those caused by antibiotic-resistant organisms. Additionally, it demonstrates efficacy against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), and has activity on biofilms. The delivery system utilizes a single-patient use, vibrating-plate nebulizer compatible with all ventilators, which generates small, uniform aerosol droplets that effectively reach the small airways and alveoli. By integrating this novel antibiotic formulation with advanced drug-delivery technology, Cardeas Pharma aims to achieve substantial clinical improvements over current treatment standards.

Inogen is a medical technology company specializing in oxygen therapy solutions for patients with chronic respiratory conditions. The company designs and manufactures portable oxygen concentrators, with its flagship product being the Inogen One system, which offers a lightweight and convenient alternative to traditional stationary oxygen concentrators and oxygen tanks. Inogen sells its products to home medical equipment providers and directly rents devices to patients, primarily generating its revenue in the United States. Additionally, the company distributes its products internationally through partnerships with large gas companies and home oxygen providers. Inogen's mission is to enhance the freedom and independence of oxygen therapy users by providing innovative and user-friendly products and services.

Apollo Endosurgery, Inc. is a medical technology company based in Austin, Texas, specializing in the design, development, and commercialization of innovative medical devices for gastrointestinal health. Founded in 2005, the company focuses on advancing therapeutic endoscopy as a less invasive alternative to traditional surgical procedures, thereby reducing complication rates and overall healthcare costs. Its product portfolio includes the OverStitch and OverStitch Sx Endoscopic Suturing Systems, which enable physicians to place full-thickness sutures and secure tissue approximation through flexible endoscopy. Additionally, Apollo offers the X-Tack Endoscopic HeliX Tacking System and the Orbera Intragastric Balloon, which aids in weight management by reducing stomach capacity. The company's devices cater to gastroenterologists and bariatric surgeons, addressing various gastrointestinal conditions such as acute perforations and chronic fistulas. Apollo Endosurgery's commitment to innovation is rooted in the collaborative efforts of a distinguished group of gastroenterologists and surgeons who aimed to enhance the field of therapeutic endoscopy.

F-Star Therapeutics is a biopharmaceutical company specializing in the development of novel bispecific antibody products. Its proprietary Modular Antibody Technology enables rapid discovery and development of bispecific antibodies, offering improved characteristics over traditional monoclonal antibodies.

ProteinSimple is a prominent company within the Protein Platforms division of Bio-Techne, specializing in innovative solutions for protein analysis. The company develops a comprehensive range of tools designed to assist life science researchers in addressing complex protein analysis challenges, thereby facilitating insights into proteins and their roles in diseases. Its product offerings include advanced immunoassay systems for quantifying protein expression and sophisticated systems for assessing the structure and purity of protein-based therapeutics. Additionally, ProteinSimple provides nano-proteomic analysis systems that enable researchers to measure phospho-protein signaling and activation in small biological samples, allowing for the quantification of phospho-protein isoforms in various cell types. Through these capabilities, ProteinSimple supports critical research in understanding cellular processes and monitoring drug actions in diverse biological contexts.

Archimedes Pharma Limited is a specialty pharmaceutical company based in Reading, United Kingdom, founded in 2004. The company develops and markets a range of products aimed at addressing specific medical needs, particularly in oncology and addiction treatment. Its product lineup includes Gliadel, which is used for treating high-grade gliomas; Zomorph, an oral sustained-release morphine formulation designed for cancer pain; Nozinan, an anti-emetic effective in managing nausea and vomiting in cancer patients; and Pabrinex, a vitamin formulation targeted at alcoholics undergoing acute withdrawal. Additionally, Archimedes Pharma offers Nasalfent, an intranasal fentanyl product for cancer pain relief. The company operates across the United Kingdom, France, and Germany, emphasizing its commitment to providing specialized healthcare solutions.

Neomend is a biomedical device company focused on developing and commercializing innovative surgical wound healing products. The company's primary technology is Pro/PEG, a bioadhesive polymer hydrogel designed to enhance the healing process. Neomend specializes in a combination wound sealant and adhesion barrier product that can be utilized during minimally invasive and laparoscopic procedures, improving patient outcomes and recovery times. Through its advanced technological solutions, Neomend aims to address critical needs in surgical wound management.

F-Star Therapeutics is a biopharmaceutical company specializing in the development of novel bispecific antibody products. Its proprietary Modular Antibody Technology enables rapid discovery and development of bispecific antibodies, offering improved characteristics over traditional monoclonal antibodies.

ProteinSimple is a prominent company within the Protein Platforms division of Bio-Techne, specializing in innovative solutions for protein analysis. The company develops a comprehensive range of tools designed to assist life science researchers in addressing complex protein analysis challenges, thereby facilitating insights into proteins and their roles in diseases. Its product offerings include advanced immunoassay systems for quantifying protein expression and sophisticated systems for assessing the structure and purity of protein-based therapeutics. Additionally, ProteinSimple provides nano-proteomic analysis systems that enable researchers to measure phospho-protein signaling and activation in small biological samples, allowing for the quantification of phospho-protein isoforms in various cell types. Through these capabilities, ProteinSimple supports critical research in understanding cellular processes and monitoring drug actions in diverse biological contexts.

Lux Biosciences, established in 2005 and headquartered in Jersey City, New Jersey, is a biotechnology company focused on developing innovative treatments for ophthalmic diseases. Its product pipeline includes LX201, an implantable device releasing cyclosporine A for extended periods; Luveniq, an oral calcineurin inhibitor voclosporin; LX212, a bioerodible polymer implant containing voclosporin; and LX214, a topical nanomicellar formulation of voclosporin for dry eye therapy. These products aim to address serious ophthalmic conditions, improving patient outcomes through effective and convenient treatment options.

Gloucester Pharmaceuticals is a biopharmaceutical company focused on developing and advancing clinical-stage oncology drug candidates. Owned by Celgene, the company specializes in hematological malignancies and is best known for its lead compound, romidepsin. This late-stage oncology drug is a histone deacetylase (HDAC) inhibitor that has demonstrated potential efficacy in treating various forms of T-cell lymphomas and other hematological cancers, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and multiple myeloma. Gloucester Pharmaceuticals retains worldwide exclusive rights to romidepsin, which has shown promise as a potent inhibitor of multiple HDAC classes in preclinical studies. The company aims to progress its drug candidates through regulatory approval and commercialization to address unmet medical needs in oncology.

ProteinSimple is a prominent company within the Protein Platforms division of Bio-Techne, specializing in innovative solutions for protein analysis. The company develops a comprehensive range of tools designed to assist life science researchers in addressing complex protein analysis challenges, thereby facilitating insights into proteins and their roles in diseases. Its product offerings include advanced immunoassay systems for quantifying protein expression and sophisticated systems for assessing the structure and purity of protein-based therapeutics. Additionally, ProteinSimple provides nano-proteomic analysis systems that enable researchers to measure phospho-protein signaling and activation in small biological samples, allowing for the quantification of phospho-protein isoforms in various cell types. Through these capabilities, ProteinSimple supports critical research in understanding cellular processes and monitoring drug actions in diverse biological contexts.

F-Star Therapeutics is a biopharmaceutical company specializing in the development of novel bispecific antibody products. Its proprietary Modular Antibody Technology enables rapid discovery and development of bispecific antibodies, offering improved characteristics over traditional monoclonal antibodies.

Inogen is a medical technology company specializing in oxygen therapy solutions for patients with chronic respiratory conditions. The company designs and manufactures portable oxygen concentrators, with its flagship product being the Inogen One system, which offers a lightweight and convenient alternative to traditional stationary oxygen concentrators and oxygen tanks. Inogen sells its products to home medical equipment providers and directly rents devices to patients, primarily generating its revenue in the United States. Additionally, the company distributes its products internationally through partnerships with large gas companies and home oxygen providers. Inogen's mission is to enhance the freedom and independence of oxygen therapy users by providing innovative and user-friendly products and services.

Lux Biosciences, established in 2005 and headquartered in Jersey City, New Jersey, is a biotechnology company focused on developing innovative treatments for ophthalmic diseases. Its product pipeline includes LX201, an implantable device releasing cyclosporine A for extended periods; Luveniq, an oral calcineurin inhibitor voclosporin; LX212, a bioerodible polymer implant containing voclosporin; and LX214, a topical nanomicellar formulation of voclosporin for dry eye therapy. These products aim to address serious ophthalmic conditions, improving patient outcomes through effective and convenient treatment options.

Lux Biosciences, established in 2005 and headquartered in Jersey City, New Jersey, is a biotechnology company focused on developing innovative treatments for ophthalmic diseases. Its product pipeline includes LX201, an implantable device releasing cyclosporine A for extended periods; Luveniq, an oral calcineurin inhibitor voclosporin; LX212, a bioerodible polymer implant containing voclosporin; and LX214, a topical nanomicellar formulation of voclosporin for dry eye therapy. These products aim to address serious ophthalmic conditions, improving patient outcomes through effective and convenient treatment options.

Celltrix is a Swedish biotechnology/medical device company focusing on reconstructive cosmetic surgery. Research, development and production are based in Malmö. They plan to launch the first product –Credurance – in 2010. Their product represents a new type of dermal filler. An immediate filling effect is achieved and the surrounding cells are presented to a matrix suitable for cell growth. As the cells grow on and inside the matrix, they produce their own environment, natural collagen, which gradually replaces the matrix — biorestoring.

ProteinSimple is a prominent company within the Protein Platforms division of Bio-Techne, specializing in innovative solutions for protein analysis. The company develops a comprehensive range of tools designed to assist life science researchers in addressing complex protein analysis challenges, thereby facilitating insights into proteins and their roles in diseases. Its product offerings include advanced immunoassay systems for quantifying protein expression and sophisticated systems for assessing the structure and purity of protein-based therapeutics. Additionally, ProteinSimple provides nano-proteomic analysis systems that enable researchers to measure phospho-protein signaling and activation in small biological samples, allowing for the quantification of phospho-protein isoforms in various cell types. Through these capabilities, ProteinSimple supports critical research in understanding cellular processes and monitoring drug actions in diverse biological contexts.

CardioOptics is a development-stage medical device company based in Boulder.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.

Corus Pharma is a biotech and specialty drug company that focuses on respiratory and infectious diseases. In other words, it is a development stage biopharmaceutical company that focuses on the development and commercialization of novel applications and formulations of known therapeutics to treat severe respiratory diseases. The products of the company are Corus 1020 and 1030. Corus 1020 is designed to treat respiratory infections in cystic fibrosis patients, using an inhalable form of an antibiotic called aztreonam. Corus 1030 is inhaled lidocaine for the treatment of patients suffering from the severe persistent forms of asthma. Corus Pharma is a U.S.-based company that was founded in 2001 and the company was acquired by Gilead Sciences on October 22, 2006.

Protein Forest, Inc. is a biotechnology company based in Lexington, Massachusetts, specializing in the development, manufacture, and marketing of instruments, consumables, and software products designed for protein separation and bioanalysis. Founded in 2002, the company offers innovative solutions such as the digital ProteomeChip (dPC), which utilizes isoelectric focusing to fractionate and concentrate proteins or peptides for mass spectrometry analysis and western blotting. Their product line includes the dPC fractionator, which operates under controlled conditions for sample processing, the dPC fractionator workflow that integrates seamlessly with existing mass spectroscopy workflows, and the dPC PlugHarvestor, allowing users to efficiently select and group pH gel plugs. Protein Forest serves a diverse clientele in the life sciences, drug discovery, pharmaceutical, biotech, and diagnostic industries, providing essential tools for scientific research and development.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.

Corus Pharma is a biotech and specialty drug company that focuses on respiratory and infectious diseases. In other words, it is a development stage biopharmaceutical company that focuses on the development and commercialization of novel applications and formulations of known therapeutics to treat severe respiratory diseases. The products of the company are Corus 1020 and 1030. Corus 1020 is designed to treat respiratory infections in cystic fibrosis patients, using an inhalable form of an antibiotic called aztreonam. Corus 1030 is inhaled lidocaine for the treatment of patients suffering from the severe persistent forms of asthma. Corus Pharma is a U.S.-based company that was founded in 2001 and the company was acquired by Gilead Sciences on October 22, 2006.

BioMimetic Therapeutics is a biotechnology company based in Franklin, Tennessee, founded in 1999. The company focuses on the development of biologically active drug-device combination products designed to stimulate the body's natural tissue regenerative processes. Its product portfolio includes Augment Injectable and Augment Rotator Cuff, which target various orthopedic and sports medicine conditions. These products are utilized for treating foot and ankle fusions, facilitating wrist fracture healing, and addressing surgical interventions for rotator cuff tears. Additionally, BioMimetic Therapeutics offers the Augment Tendinopathy Injection, aimed at managing injuries resulting from tendon overuse. The company is dedicated to advancing solutions for the healing of injuries and diseases affecting the skeleton and associated tissues.