Medtronic

Rosenbot provides medical robot technology and uses technological innovation to promote the reform of medical models. It is committed to creating a new generation of orthopedic surgery robot systems with intelligent fracture reduction functions, it is the first in the world to realize advanced technologies such as intraoperative real-time 3D navigation, assisted fracture reduction operation, automatic operation planning, etc. The intelligent surgical operation of the whole operation process meets the urgent needs of clinical treatment.

Fire1 is a Dublin-based company dedicated to developing innovative therapeutic devices aimed at enhancing the quality of life for heart failure patients. The company has created a remote monitoring system that delivers real-time patient data and insights to healthcare providers. This technology facilitates the early detection of complications associated with heart failure, allowing for proactive interventions and ultimately leading to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to transform the management of heart failure and support better health management for patients.

Fortimedix B.V., founded in 1999 and based in Nuth, the Netherlands, specializes in the development and manufacturing of endovascular, coronary, and peripheral stents. As a global leader in stent technology, the company has established a strong presence in the medical device industry, focusing on innovation and continuous improvement. With full in-house capabilities for stent development and production, Fortimedix is dedicated to operational excellence. The company prioritizes research and development to advance its technology and meet the evolving needs of its customers and stakeholders.

Avation Medical, Inc. is a company focused on developing a non-invasive closed-loop neuromodulation system aimed at treating overactive bladder in a home setting. Incorporated in 2016 and based in Columbus, Ohio, Avation Medical is at the forefront of innovation in wearable nerve stimulation systems. The company emphasizes empowering patients to manage their therapies, facilitating a more personalized approach to care. By leveraging advanced technologies, Avation Medical seeks to transform the neuromodulation market, enhancing the quality of care for individuals with chronic conditions through patient-centric solutions.

EOFlow Co., Ltd. is a South Korean company specializing in drug delivery solutions, particularly in the development of wearable insulin pumps. Its flagship product, EOPatch, is recognized as the world's smallest full-featured disposable insulin pump, designed to be smarter, better-connected, and longer-lasting than competing devices, all while being more cost-effective. The company plans to enhance EOPatch with a software upgrade that will enable closed-loop insulin control, effectively functioning as an automated insulin delivery system or "artificial pancreas." Additionally, EOFlow is working on an all-in-one wearable disposable artificial pancreas solution, which has received Breakthrough Device designation from the FDA, highlighting its potential impact on diabetes management.

Fire1 is a Dublin-based company dedicated to developing innovative therapeutic devices aimed at enhancing the quality of life for heart failure patients. The company has created a remote monitoring system that delivers real-time patient data and insights to healthcare providers. This technology facilitates the early detection of complications associated with heart failure, allowing for proactive interventions and ultimately leading to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to transform the management of heart failure and support better health management for patients.

CathWorks Ltd. is a medical technology company that specializes in enhancing percutaneous coronary intervention (PCI) therapy decisions through its advanced computational science platform. Founded in 2013 and headquartered in Kfar-Saba, Israel, with an additional office in the United States, CathWorks aims to transform coronary angiography from subjective visual assessments into an objective decision-making tool. The company's flagship product, CathWorks FFRangio, is a non-invasive device that provides multi-vessel physiologic measurements, allowing physicians to optimize and confirm PCI therapy decisions during procedures. By leveraging functional flow reserve (FFR) data and automated algorithms, CathWorks enhances the use of coronary angiography data, promoting measurement-based medicine and improving operational efficiency in cath labs.

CathWorks Ltd. is a medical technology company that specializes in enhancing percutaneous coronary intervention (PCI) therapy decisions through its advanced computational science platform. Founded in 2013 and headquartered in Kfar-Saba, Israel, with an additional office in the United States, CathWorks aims to transform coronary angiography from subjective visual assessments into an objective decision-making tool. The company's flagship product, CathWorks FFRangio, is a non-invasive device that provides multi-vessel physiologic measurements, allowing physicians to optimize and confirm PCI therapy decisions during procedures. By leveraging functional flow reserve (FFR) data and automated algorithms, CathWorks enhances the use of coronary angiography data, promoting measurement-based medicine and improving operational efficiency in cath labs.

Beijing Surgerii Technology Co., Ltd. specializes in the research, development, production, and sale of minimally invasive surgical robot systems in China. Founded in 2014 and based in Beijing, the company focuses on innovative technologies, particularly the next generation of flexible continuum robotic arms. Surgerii Technology aims to transform clinical practices through its single-hole and porous laparoscopic robot systems, enhancing the standard of care in minimally invasive surgeries. With a commitment to independent research and development, the company leverages its expertise in system design and integration to advance the medical equipment industry in China.

Orchestra BioMed is a biomedical innovation company based in New Hope, Pennsylvania, founded in 2017. The company specializes in developing high-impact therapeutic solutions for major medical conditions, with a primary focus on cardiovascular diseases, which are responsible for approximately 31% of global deaths annually. Orchestra BioMed's business model involves strategic partnerships with medical device companies to accelerate the commercialization of its products. Its key product candidates include BackBeat Cardiac Neuromodulation Therapy for hypertension and Virtue Sirolimus AngioInfusionBalloon for atherosclerotic artery disease.

Titan Medical Inc. is a research and development stage company based in Toronto, Canada, specializing in the design and development of robotic surgical technologies for minimally invasive surgery (MIS). The company is advancing its flagship product, the SPORT Surgical System, which features a surgeon-controlled patient cart equipped with a 3D high-definition vision system and multi-articulating instruments. This system enables surgeons to perform a variety of surgical procedures, including gynecologic, urologic, colorectal, and abdominal surgeries, through a single port. Additionally, Titan Medical is also developing the Enos robotic single-access surgical system, further enhancing its focus on innovative solutions in the field of robotic-assisted surgery.

Affera, Inc. is a medical technology company founded in 2013 and based in Watertown, Massachusetts. It focuses on developing innovative solutions for the treatment of cardiac arrhythmia, a common condition that affects millions of patients globally. The company is engaged in the design and development of a novel medical system aimed at addressing the unmet needs in the treatment of heart rhythm disorders. Through its advancements, Affera seeks to enhance the capabilities of healthcare institutions in managing and treating these conditions effectively.

Beijing Surgerii Technology Co., Ltd. specializes in the research, development, production, and sale of minimally invasive surgical robot systems in China. Founded in 2014 and based in Beijing, the company focuses on innovative technologies, particularly the next generation of flexible continuum robotic arms. Surgerii Technology aims to transform clinical practices through its single-hole and porous laparoscopic robot systems, enhancing the standard of care in minimally invasive surgeries. With a commitment to independent research and development, the company leverages its expertise in system design and integration to advance the medical equipment industry in China.

Rockley Photonics Limited, founded in 2013 and based in London, United Kingdom, specializes in developing silicon photonics technologies for diverse applications. The company focuses on creating integrated optical modules, sensors, and comprehensive solutions that cater to high-volume and dynamic market sectors. Rockley aims to revolutionize mobile health monitoring and machine vision with its next-generation sensing platforms, while also providing high-speed solutions for data communications. By leveraging its innovative photonic integrated circuits and associated modules, Rockley is positioned to address a wide array of vertical applications, believing that photonics will become as ubiquitous as microelectronics in the future. The company combines hardware with supporting electronics, software, application algorithms, and AI platforms, establishing a robust foundation for future developments across multiple industries.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.

Scivita Medical is a high-tech enterprise specializing in optical diagnosis and treatment, as well as the development of multidimensional imaging technologies and high-performance materials. The company focuses on precision manufacturing for minimally invasive medical procedures and is recognized for its advancements in endoscopy technology. Scivita Medical offers a range of products that include flexible and rigid endoscopes, featuring innovations such as ultra-high-definition visualization, 3D imaging, and specialized light visualization techniques, including fluorescence. Its portfolio encompasses various medical devices, including 4K medical endoscope camera systems, integrated endoscope systems, and single-use electronic instruments like hysteroscopes, bladder pyeloscopes, and bronchoscopes. These products are designed to provide healthcare professionals with efficient tools for diagnosis and treatment, enhancing the capabilities of modern endoscopic procedures.

Marblehead Medical specializes in the development of a novel medical device designed to enhance the effectiveness of mechanical thrombectomy procedures in treating ischemic strokes. Their innovative device aims to improve support for distal access devices, boost suction efficiency, minimize the risk of embolic events, and accommodate modern catheters, ultimately offering stroke patients improved treatment options.

BrainsGate, Ltd. is a medical device company based in Caesarea, Israel, specializing in therapies for central nervous system diseases, particularly acute ischemic stroke. Founded in 2000, the company has developed a technology platform that utilizes electrical stimulation of the spheno-palatine ganglion (SPG) to enhance cerebral blood flow. Its innovative treatment approach involves a miniature electrode implanted in the roof of the mouth through a minimally invasive procedure performed under local anesthesia. BrainsGate's key product is an ischemic stroke system that delivers targeted stimulation to the SPG, with the aim of improving outcomes for stroke patients. The company has conducted significant clinical trials, including a pivotal study with 300 participants that demonstrated the safety and efficacy of its treatment. Currently, BrainsGate is advancing the ImpACT-24b trial, a multinational randomized study assessing the treatment's effectiveness within a critical 24-hour window following stroke onset.

Ai Biomed is a Santa Barbara-based company that specializes in the development of advanced parathyroid detection systems. Its technology enables the real-time identification of parathyroid tissue during various surgical procedures, including thyroidectomy and parathyroidectomy, as well as radical neck dissection. This innovative approach enhances surgical accuracy and patient safety by facilitating the preservation of critical parathyroid glands during operations.

Triple Jump Medical is a developer of an insulin pump intended to treat diabetic patients.

BioProtect Ltd. is an international medical device startup founded in 2004 and headquartered in Israel, with subsidiaries in Germany and the United States. The company specializes in the development and commercialization of biodegradable balloon spacers designed to protect normal tissue during radiation therapy for cancer. Its flagship product, the ProSpace balloon spacer, has received CE marking and demonstrates superior efficacy and safety in safeguarding the rectum during prostate cancer radiation therapy. By creating a temporary separation between the rectum and targeted tissues, BioProtect's technology significantly reduces the risk of serious and chronic side effects associated with radiation treatment while enhancing tumor control. Additionally, the company's platform of biodegradable implantable balloons addresses a variety of unmet clinical needs in the growing radiotherapy spacers market.

Companion Medical, Inc. is a company focused on enhancing diabetes management through innovative medical technology. Based in San Diego, California, it develops the InPen, a smart insulin delivery system that integrates a wireless insulin pen with a mobile application. This system calculates and recommends optimal insulin dosing, tracks injection history and timing, monitors insulin temperature, and keeps patients informed about their last dose and remaining insulin. The InPen's features allow users to report their data to healthcare providers, facilitating better management of their condition. Incorporated in 2013, Companion Medical operates as a subsidiary of Medtronic plc, leveraging its expertise in medical devices to improve patient care for those who rely on insulin.

Sinovation Medical specializes in the development of advanced medical robot technology and intelligent medical products. The company designs innovative medical devices aimed at delivering enhanced precision care. Their surgical robots employ clinical computer visioning technology to offer precise solutions for doctors and medical institutions. These products are primarily used in neurosurgery, addressing conditions such as epilepsy, Parkinson's disease, cerebral hemorrhage, and intracranial tumors. Sinovation Medical provides reliable medical robotics to clients, focusing on improving the accuracy and effectiveness of surgical procedures.

Medicrea is a specialized spinal implant company committed to delivering innovative technologies aimed at improving patient outcomes in spinal surgery. With over 18 years of experience, the company designs, develops, and manufactures a comprehensive range of patented products. Its offerings include personalized analytical services and implant systems, such as the UNiD Adaptive Spine Intelligence technology, as well as various spinal implant ranges, including the PASS Range, Cervical Range, and TH-LUMBAR Range. These products are intended to provide long-lasting pain relief and enhance the effectiveness of medical professionals in treating spinal conditions.

Digital Surgery is a privately-held pioneer in surgical artificial intelligence (AI), data and analytics, and digital education and training.

Stimgenics is a private company that pioneered a novel spinal cord stimulation waveform known as Differential Target Multiplexed (DTM) Spinal Cord Stimulation.

Klue, Inc. is a digital health technology company founded in 2016 and based in San Mateo, California. It focuses on developing artificial intelligence-based software and wearable technology aimed at promoting healthier eating habits. By leveraging behavioral AI, Klue's solutions help users detect meals and gain insights into their eating behaviors, addressing issues such as obesity. As a subsidiary of Medtronic plc, Klue is positioned to contribute to advancements in digital health and nutrition through its innovative approach to personal wellness.

AV Medical Technologies is a medical device company focused on developing catheter-based interventions specifically for dialysis patients undergoing routine angioplasty procedures. Its flagship product, the Chameleon PTA balloon catheter, incorporates Supervision technology, which enables targeted injection of diagnostic fluids for enhanced visualization during procedures. This innovative approach allows physicians to determine the status of the balloon—whether inflated or deflated—while maintaining wire position, thereby improving procedural efficiency and safety for both patients and operators. The Chameleon catheter has undergone clinical testing in various dialysis access procedures, demonstrating its potential to enhance patient care in this critical medical area.

Saluda Medical Pty Ltd. is a medical device company specializing in the development of neuromodulation technologies for chronic neurological conditions. Founded in 2010 and based in Artarmon, Australia, with additional offices in the United States and the United Kingdom, Saluda Medical focuses on its innovative Evoke system. This investigational device employs a closed-loop spinal cord stimulation approach that continuously monitors the spinal cord's response to stimulation and adjusts treatment in real-time to optimize patient outcomes. By utilizing a unique dose-control platform, Saluda Medical aims to customize therapy based on individual neural responses, thereby improving the management of chronic pain, particularly in patients suffering from conditions such as neuropathic pain and chronic back pain.

Titan Spine, Inc. is a designer and manufacturer of interbody fusion devices specifically tailored for the cervical and lumbar spine. The company's product lineup includes various devices such as Endoskeleton TL for lateral lumbar fusion, Endoskeleton TAS for anterior lumbar interbody fusion with screws, and Endoskeleton TT for transforaminal lumbar interbody fusion. Additionally, it provides cervical interbody devices like Endoskeleton TCS for anterior discectomy and fusion. Titan Spine aims to enhance treatment outcomes through its innovative implant designs, which feature textured surfaces at multiple levels to improve integration and recovery. The company serves patients across the United States and Europe, utilizing a dedicated sales force and a network of independent distributors. Founded in 2005 and headquartered in Mequon, Wisconsin, with a presence in Laichingen, Germany, Titan Spine operates as a subsidiary of Medtronic plc.

EPIX Therapeutics, Inc. is a medical device company focused on developing innovative temperature-sensing irrigated radiofrequency ablation catheters for treating atrial fibrillation and other cardiac arrhythmias. The company utilizes its proprietary TempaSure technology, which employs microwave radiometry to provide real-time assessment of temperature within the heart, allowing physicians to accurately control lesion formation and enhance clinical outcomes. Founded in 2007 and headquartered in Santa Clara, California, EPIX Therapeutics was previously known as Advanced Cardiac Therapeutics, Inc. and rebranded in August 2018. The company has established strategic partnerships with industry leaders, including Abbott Laboratories and Hansen Medical Inc., to further advance its catheter-based systems aimed at improving the management of irregular heart rhythms. EPIX Therapeutics operates as a subsidiary of Medtronic plc.

Nutrino Health Ltd. is a Tel Aviv-based company that specializes in developing a nutrition insights software platform aimed at providing personalized meal recommendations and health analytics. Founded in 2011, Nutrino utilizes a unique approach known as FoodPrint, which analyzes an individual's biochemistry to offer tailored dietary suggestions that align with their personal health goals and preferences. The platform integrates data from wearables and employs advanced technologies such as image recognition to enhance its nutritional insights. By serving individuals, businesses, and professionals, Nutrino enables users to better understand how food impacts their bodies, facilitating healthier lifestyle choices. As of November 2018, Nutrino operates as a subsidiary of Medtronic plc.

Mazor Robotics, founded in 2001 and headquartered in Caesarea, Israel, specializes in developing, producing, and marketing medical devices for orthopedic and neurosurgical procedures. The company's primary focus is on surgical robotic-guidance systems that enhance precision and minimize invasiveness during complex surgeries. Their flagship products include the Mazor X and Renaissance systems, which are used extensively in spine surgeries such as fusion, correction of spinal deformities, biopsy collection, tumor excision, and cement augmentations. These systems aim to provide a safer surgical environment for patients, surgeons, and operating room staff by transforming traditional freehand procedures into highly accurate, state-of-the-art operations with better clinical outcomes.

MC10, Inc. is a company that specializes in developing wearable medical sensors designed to collect clinical-grade biometric and physiological data. Founded in 2008 and based in Lexington, Massachusetts, the company offers a range of innovative products, including BioStamp nPoint for vital signs and activity monitoring, Kintinuum for orthopedic rehabilitation, WiSP for cardiac monitoring, and BioStampMD, a conformal sensor that gathers both objective and subjective health data. MC10 employs advanced flexible electronics technology, allowing its devices to bend and stretch with the body, ensuring comfort and ease of use. The company focuses on enhancing human capabilities and improving health insights through discreet, location-specific sensing that captures real-world data on muscle activation and movement, with applications extending across various sectors including sports, military, and energy.

Nanos Medical specializes in the research, development, manufacturing, and sales of disposable medical devices, primarily targeting the cardiovascular and ear, nose, and throat (ENT) fields. The company offers a range of innovative products, including sinus balloon catheters, eustachian tube balloons, disposable nasopharyngeal airways, nasolacrimal balloons, and drug-eluting stents for sinus applications. Through its advanced medical devices, Nanos Medical aims to enhance treatment options for hospitals and patients, contributing to improved healthcare outcomes.

Yosemite Clinic is a comprehensive medical facility located in Central Pudong, Shanghai, offering a wide range of walk-in medical services. The clinic specializes in various fields, including family and internal medicine, surgery, orthopedics, dermatology, medical cosmetology, dentistry, gynecology, pediatrics, ophthalmology, and rehabilitation medicine. Equipped with advanced technology, Yosemite Clinic features state-of-the-art facilities such as CT, X-ray, ultrasound, and operating rooms, ensuring high-quality care. The clinic's diverse team of medical professionals, hailing from both China and around the globe, allows it to provide services in multiple languages, including English, Japanese, Malay, Mandarin Chinese, and Cantonese. By combining a multidisciplinary approach with modern medical practices, Yosemite Clinic aims to meet the diverse healthcare needs of its patients effectively.

VisionSense is a company focused on developing innovative visualization solutions for minimally invasive surgery (MIS). By utilizing advanced sensor technology and proprietary software, VisionSense provides a system that offers natural stereoscopic sight, delivering depth perception and 3D-HD resolution images. This technology allows for maneuvering flexibility through the smallest access points, addressing the limitations of traditional 2D (monocular) imaging that often hinders a surgeon's perspective. With enhanced tissue understanding and improved hand-eye coordination, surgeons are empowered to perform more complex procedures with greater confidence, particularly when using advanced articulating surgical tools.

Fire1 is a Dublin-based company dedicated to developing innovative therapeutic devices aimed at enhancing the quality of life for heart failure patients. The company has created a remote monitoring system that delivers real-time patient data and insights to healthcare providers. This technology facilitates the early detection of complications associated with heart failure, allowing for proactive interventions and ultimately leading to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to transform the management of heart failure and support better health management for patients.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, that specializes in innovative treatments for women's health. The company has developed a water vapor ablation system, known as Mara, which is designed for the in-office treatment of heavy menstrual bleeding, specifically menorrhagia. This FDA-approved technology utilizes adaptive vapor ablation to deliver safe and effective endometrial ablation in a simple procedure that takes only minutes. AEGEA Medical aims to expand treatment options for a broader range of patients while ensuring convenience and confidence for physicians performing these office-based procedures. The company was incorporated in 2007 and continues to focus on enhancing patient outcomes in women's healthcare.

Crospon Limited is a medical device company focused on developing minimally invasive technologies for imaging and assisting surgeries in the esophagus and stomach. Founded in 2006 and based in Galway, Ireland, Crospon offers a range of products, including the EndoFLIP imaging system, which measures the dimensions and function of hollow organs and sphincteric regions. Its product lineup also includes measurement and dilation catheters, along with various endoscopic and laparoscopic accessories. Crospon's technologies are utilized in applications such as upper gastrodiagnostics, bariatric surgery, upper GI imaging, cardiology, therapeutic endoscopy, and colorectal imaging. The company distributes its products across multiple regions, including the United States, Europe, and parts of Africa and Latin America. As of December 2017, Crospon operates as a subsidiary of Medtronic plc.

Semma Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative cell therapies for patients with Type 1 diabetes. Founded in 2014, the company is dedicated to creating a transformative treatment that addresses the need for insulin injections by generating functional, insulin-producing beta cells through a proprietary method licensed from the laboratory of Professor Douglas Melton. Semma Therapeutics aims to combine these engineered cells with advanced devices to offer a potential replacement for the missing beta cells in diabetic patients, eliminating the need for immunosuppression. The company's ongoing research seeks to bring this novel therapeutic option to clinical settings, ultimately improving the lives of individuals living with diabetes.

Mazor Robotics, founded in 2001 and headquartered in Caesarea, Israel, specializes in developing, producing, and marketing medical devices for orthopedic and neurosurgical procedures. The company's primary focus is on surgical robotic-guidance systems that enhance precision and minimize invasiveness during complex surgeries. Their flagship products include the Mazor X and Renaissance systems, which are used extensively in spine surgeries such as fusion, correction of spinal deformities, biopsy collection, tumor excision, and cement augmentations. These systems aim to provide a safer surgical environment for patients, surgeons, and operating room staff by transforming traditional freehand procedures into highly accurate, state-of-the-art operations with better clinical outcomes.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Glooko is a company that develops a remote patient-monitoring platform specifically designed for individuals with diabetes. This platform integrates with various diabetes devices, fitness wearables, and activity trackers to capture and sync health data. It provides comprehensive reports and analytics aimed at promoting behavior change and improving health outcomes. By enhancing communication between patients and healthcare providers, Glooko facilitates better management of diabetes and supports remote monitoring efforts. The platform is accessible on both Android and iOS devices, allowing users to conveniently track their diabetes-related information on their smartphones.

EarLens is a privately held medical technology company focused on enhancing the hearing experience for individuals with hearing loss. The firm has pioneered the Earlens Contact Hearing Solution, a groundbreaking device that directly activates the natural hearing process. This innovative system utilizes low-frequency radio signals and a small lens placed on the eardrum to vibrate it, allowing for superior sound quality and a broader bandwidth than traditional hearing aids. Unlike conventional devices that amplify sound, the Earlens solution delivers sound directly to the eardrum, thereby minimizing feedback and ensuring clear hearing in various environments. The second generation of this technology received FDA clearance in 2019, marking a significant advancement in the standard of care for hearing performance.

Saluda Medical Pty Ltd. is a medical device company specializing in the development of neuromodulation technologies for chronic neurological conditions. Founded in 2010 and based in Artarmon, Australia, with additional offices in the United States and the United Kingdom, Saluda Medical focuses on its innovative Evoke system. This investigational device employs a closed-loop spinal cord stimulation approach that continuously monitors the spinal cord's response to stimulation and adjusts treatment in real-time to optimize patient outcomes. By utilizing a unique dose-control platform, Saluda Medical aims to customize therapy based on individual neural responses, thereby improving the management of chronic pain, particularly in patients suffering from conditions such as neuropathic pain and chronic back pain.

Semma Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative cell therapies for patients with Type 1 diabetes. Founded in 2014, the company is dedicated to creating a transformative treatment that addresses the need for insulin injections by generating functional, insulin-producing beta cells through a proprietary method licensed from the laboratory of Professor Douglas Melton. Semma Therapeutics aims to combine these engineered cells with advanced devices to offer a potential replacement for the missing beta cells in diabetic patients, eliminating the need for immunosuppression. The company's ongoing research seeks to bring this novel therapeutic option to clinical settings, ultimately improving the lives of individuals living with diabetes.

Forerunner Medical (Shanghai) Co., Ltd., established in 2009, specializes in the development and manufacturing of innovative medical devices aimed at minimally invasive treatments. The company focuses on creating low-temperature plasma radio-frequency generators and electrodes specifically designed for sports medicine and tumor treatment. By leveraging extensive domestic clinical data and advanced technology, Forerunner Medical aims to meet both domestic and global healthcare needs. The organization emphasizes the quality and safety of its products, ensuring high performance, aesthetic appeal, and user convenience. Its commitment to excellence is reflected in its state-of-the-art production equipment and professional expertise, which contribute to its competitive advantage in the medical device industry.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

MD Start SA is a medical technology incubator based in Lausanne, Switzerland, that specializes in transforming innovative ideas into viable medical solutions. Founded in 2009, the company creates, develops, and operates medical projects, effectively turning them into new companies. MD Start employs both strategic and hands-on approaches to guide these projects through the investment stage and into commercial development. The firm collaborates with notable partners in the medical device sector, including Medtronic, Sofinnova Partners, and Versant Ventures, among others. Through its focused efforts, MD Start aims to support the growth of medical device start-ups and facilitate the advancement of healthcare technologies.

Mazor Robotics, founded in 2001 and headquartered in Caesarea, Israel, specializes in developing, producing, and marketing medical devices for orthopedic and neurosurgical procedures. The company's primary focus is on surgical robotic-guidance systems that enhance precision and minimize invasiveness during complex surgeries. Their flagship products include the Mazor X and Renaissance systems, which are used extensively in spine surgeries such as fusion, correction of spinal deformities, biopsy collection, tumor excision, and cement augmentations. These systems aim to provide a safer surgical environment for patients, surgeons, and operating room staff by transforming traditional freehand procedures into highly accurate, state-of-the-art operations with better clinical outcomes.

HeartWare International, Inc. specializes in the development and manufacturing of small implantable heart pumps, also known as ventricular assist devices, aimed at treating advanced heart failure. The company offers the HeartWare Ventricular Assist System, which comprises a left ventricular assist device, patient accessories, and surgical tools designed to provide critical circulatory support for patients in the advanced stages of heart failure. Additionally, HeartWare is working on the Miniaturized Ventricular Assist Device, intended for chronic heart failure patients. The company markets its products through clinical studies in the United States and directly to cardiac centers and hospitals worldwide. Headquartered in Framingham, Massachusetts, HeartWare is committed to improving the quality of life for patients suffering from severe heart conditions.

EarLens is a privately held medical technology company focused on enhancing the hearing experience for individuals with hearing loss. The firm has pioneered the Earlens Contact Hearing Solution, a groundbreaking device that directly activates the natural hearing process. This innovative system utilizes low-frequency radio signals and a small lens placed on the eardrum to vibrate it, allowing for superior sound quality and a broader bandwidth than traditional hearing aids. Unlike conventional devices that amplify sound, the Earlens solution delivers sound directly to the eardrum, thereby minimizing feedback and ensuring clear hearing in various environments. The second generation of this technology received FDA clearance in 2019, marking a significant advancement in the standard of care for hearing performance.

Responsive Orthopedics LLC is a Minneapolis-based company that specializes in designing and developing knee implant systems for the healthcare marketplace. Founded in 2013, the company focuses on providing low-cost hip and knee replacements intended for healthcare providers involved in federal programs aimed at reducing the expenses associated with hip and knee procedures. In addition to its product offerings, Responsive Orthopedics also offers logistical support to physician practices and hospitals. In June 2016, the company became a subsidiary of Medtronic plc, enhancing its capabilities and reach within the medical device industry.

Gynaecology has been rapidly built around Smith & Nephew's resection technologies and comprises, primarily, the TRUCLEAR◊ System for the hysteroscopic resection and removal of uterine tissue. Gynaecology delivered revenue of $56 million in 2015, representing a little over 1% of Group revenue.

Bellco is an Italian company recognized as a pioneer in the field of haemodialysis, dedicated to addressing the needs of patients and healthcare professionals through innovation and research. The company specializes in the manufacturing and distribution of medical devices for renal care, including dialyzers, fluids, machines, and hematic lines designed for the treatment of kidney diseases. In addition to its focus on haemodialysis, Bellco develops equipment for extra-corporeal blood filtration, supporting advanced therapies in Nephrology, Intensive Care, and Cardiology. Through its commitment to technological advancement, Bellco continues to play a significant role in improving patient care in the realm of renal health.

Aircraft Medical Limited is a developer and producer of handheld medical devices specializing in anesthesia and critical care. Founded in 2001 and based in Edinburgh, United Kingdom, the company is known for its flagship product, the McGRATH, a portable video laryngoscope designed to enhance the intubation process. Aircraft Medical's innovations aim to provide life-saving technology for anesthesia professionals, focusing on reducing patient trauma, minimizing cross-contamination, and improving communication and efficiency in clinical training. The company distributes its products through partners across various regions, including the United States, Canada, the United Kingdom, and several countries in Europe and Australasia. Aircraft Medical was formerly known as Smartscope MD Ltd. and adopted its current name in February 2004. As of November 2015, it operates as a subsidiary of Medtronic plc.

Lazarus Effect is a medical device company dedicated to creating innovative interventional devices designed to enhance the removal of blood clots. The company is focused on developing a comprehensive portfolio of vascular-device products leveraging a patented wire-frame technology platform. Currently, Lazarus Effect holds five issued US patents along with several pending patent applications both in the US and internationally. The company’s notable products include the Lazarus Funnel™ Guide Catheter and the Lazarus ReCover devices, which have received CE Mark approval for use in Europe, while the Funnel is also cleared for use in the United States. The Lazarus Cover device is in the process of obtaining CE Mark approval. However, the ReCover and Cover devices are not yet authorized for sale in the United States.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for the treatment of debilitating inflammatory diseases. Established in 2006 and formerly known as Innovative Metabolics Inc., the company aims to provide innovative solutions for chronic autoimmune conditions such as rheumatoid arthritis and inflammatory bowel disease. SetPoint Medical's technology leverages vagus nerve stimulation to activate the body's natural inflammatory reflex, producing a systemic anti-inflammatory effect. This platform offers an alternative treatment option that may present lower risks and costs compared to traditional drug therapies, ultimately seeking to improve patient outcomes in managing chronic inflammatory diseases.

Medina is a medical laboratory that provides analysis and diagnostics services.

Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.

RF Surgical Systems, Inc. specializes in detection technology aimed at preventing retained surgical sponges in hospitals and trauma centers across the United States. Founded in 2004 and based in Carlsbad, California, the company offers a range of products including the RF Assure Detection System X, antenna array body scanners, and handheld scanning devices tailored for various clinical applications. Its technology is utilized in over 1,500 operating rooms and trauma and labor delivery suites nationwide, with more than 70 hospitals and surgical centers adopting its solutions since 2011. The RF Surgical Detection System is protected by U.S. patents and received regulatory clearance from the U.S. Food and Drug Administration in November 2006, establishing the company as a leader in ensuring patient safety during surgical procedures. RF Surgical Systems operates as a subsidiary of Medtronic plc.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology called Electrocardiographic Mapping (ECM), which generates three-dimensional images of the heart's electrical activity by integrating body surface electrical data with anatomical data obtained from CT scans. The CardioInsight system employs a single-use disposable multi-sensor vest to capture electrical signals from the body surface, enabling the creation of detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach allows physicians to visualize real-time cardiac electrical activity and enhances the accuracy of diagnosing and treating conditions such as arrhythmias and congestive heart failure. CardioInsight's technology has been validated through over 260 patient studies, demonstrating its effectiveness in guiding therapeutic interventions. Founded in 2006, the company operates as a subsidiary of Medtronic plc.

Aptus Endosystems, Inc. is a medical device company focused on developing advanced solutions for endovascular aneurysm repair (EVAR). Founded in 2002 and based in Sunnyvale, California, the company has created innovative technologies such as the Heli-FX EndoAnchor system, which provides a durable method for treating abdominal and thoracic aortic aneurysms. This system employs unique helical staple technology that allows for independent fixation of endografts, mimicking the precision of open surgical suturing while facilitating minimally invasive procedures. Additionally, Aptus Endosystems offers the Aptus TourGuide, a steerable sheath designed to enhance access and delivery of peripheral vascular products. The company's products are distributed in key markets including the United States and several European countries, and the Aptus Endovascular AAA Repair Systems hold CE Marking for distribution within the European Union.

AEGEA Medical, Inc. is a medical technology company based in Menlo Park, California, that specializes in innovative treatments for women's health. The company has developed a water vapor ablation system, known as Mara, which is designed for the in-office treatment of heavy menstrual bleeding, specifically menorrhagia. This FDA-approved technology utilizes adaptive vapor ablation to deliver safe and effective endometrial ablation in a simple procedure that takes only minutes. AEGEA Medical aims to expand treatment options for a broader range of patients while ensuring convenience and confidence for physicians performing these office-based procedures. The company was incorporated in 2007 and continues to focus on enhancing patient outcomes in women's healthcare.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Founded in 2006, the company develops innovative diagnostic technology solutions for assessing spinal health. Its flagship product, the KineGraph Vertebral Motion Analyzer, employs fluoroscopy to capture spine motion and produce detailed patient-specific graphs that assist clinicians in diagnosing spinal instability and related conditions. In addition to its diagnostic devices, Ortho Kinematics offers comprehensive spine diagnostic imaging services through its imaging center in Austin, providing valuable information to healthcare professionals for the effective treatment of back and neck pain.

DreaMed Diabetes, Ltd. is an Israel-based company founded in 2014 that specializes in developing innovative solutions for diabetes treatment and management. The company has created a portfolio that includes Glucositter, a closed-loop insulin delivery system designed to monitor glucose levels in real-time and optimize insulin adjustments. DreaMed Diabetes is recognized for commercializing the first artificial pancreas technology, which has been validated in leading medical journals. It has also pioneered decision support tools for diabetes management, being the first company to receive FDA clearance for a system utilizing data from continuous glucose monitors and insulin pumps. Its Advisor Pro software, developed by diabetes professionals, leverages artificial intelligence to enable healthcare providers to quickly analyze patient data and recommend personalized treatment plans. Through frequent insulin titration and online monitoring, DreaMed Diabetes aims to enhance patient care by reducing A1C levels and the risk of complications, ensuring that all patients receive high-quality treatment regardless of their location or caregiver.

Diabeter is an independent diabetes clinic and research center based in the Netherlands, dedicated to transforming diabetes care and improving patient outcomes. The organization focuses on providing comprehensive diabetes services, including diagnosis, insulin pen treatment, and insulin pump therapy. In addition to these clinical services, Diabeter offers e-health solutions, educational resources, and daily telephone consultations with diabetes specialists, ensuring that patients receive continuous support. By emphasizing individualized care, Diabeter aims to help patients manage their condition effectively and reduce the risk of diabetes-related complications, ultimately striving for a future where such complications are minimized.

Sophono, Inc. is a medical device manufacturer based in Boulder, Colorado, specializing in magnetic bone conduction hearing devices designed for patients with conductive hearing loss, mixed hearing loss, and single-sided deafness. Founded in 2009, the company produces innovative products such as the Alpha 1 and Alpha 2 MPO hearing devices, which utilize a unique abutment-free design that allows for the implantation of sound processors beneath the skin. These devices aim to provide effective solutions for individuals experiencing severe to profound hearing impairment. Sophono sells its products through clinics and operates as a subsidiary of Medtronic plc as of 2015.

Semma Therapeutics, Inc. is a biotechnology company based in Cambridge, Massachusetts, focused on developing innovative cell therapies for patients with Type 1 diabetes. Founded in 2014, the company is dedicated to creating a transformative treatment that addresses the need for insulin injections by generating functional, insulin-producing beta cells through a proprietary method licensed from the laboratory of Professor Douglas Melton. Semma Therapeutics aims to combine these engineered cells with advanced devices to offer a potential replacement for the missing beta cells in diabetic patients, eliminating the need for immunosuppression. The company's ongoing research seeks to bring this novel therapeutic option to clinical settings, ultimately improving the lives of individuals living with diabetes.

Glooko is a company that develops a remote patient-monitoring platform specifically designed for individuals with diabetes. This platform integrates with various diabetes devices, fitness wearables, and activity trackers to capture and sync health data. It provides comprehensive reports and analytics aimed at promoting behavior change and improving health outcomes. By enhancing communication between patients and healthcare providers, Glooko facilitates better management of diabetes and supports remote monitoring efforts. The platform is accessible on both Android and iOS devices, allowing users to conveniently track their diabetes-related information on their smartphones.

Advanced Uro-Solutions is a medical device company specializing in the development and manufacture of innovative solutions for various health conditions. The company's flagship product is the NURO percutaneous tibial nerve stimulation system, which includes a compact external stimulator and a reusable lead designed to provide temporary stimulation to the tibial nerve. This system addresses urinary urgency and incontinence, as well as other related disorders. In addition to its core focus on urinary health, Advanced Uro-Solutions also develops medical devices for bowel control disorders, cardiac rhythm disorders, and neurological conditions, reflecting its commitment to enhancing patient care across multiple health issues.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at improving near vision. Founded in 2001, the company develops and markets innovative solutions for presbyopia, including the KAMRA inlay, which helps patients restore their near vision without compromising distance vision. Additionally, AcuFocus offers the IC-8 IOL, a small aperture lens designed for cataract patients, providing a broad range of vision from near to far distances. The company also produces the AcuTarget HD, a diagnostic and surgical planning instrument that assists in the optimal treatment selection for various eye conditions such as LASIK, cataracts, and dry eye. AcuFocus distributes its products through partners across the Americas, Asia-Pacific, Europe, and the Middle East, serving both physicians and patients in the vision care market.

Founded by Dr. Eugenio Cremascoli, the main business of NGC Medical Focuses are: Project planning, manufacturing and marketing of medical and surgical devices Import and distribution in national territory of medical devices, medical data management systems, medical communications database for remote access and medical equipment Design and turnkey implementation of Surgery Units, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories In-service management of Surgical Suites, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories Design and implementation of Information Management Software packages unifying the administrative and clinical departments within at single interface

Sapiens Steering Brain Stimulation GmbH is a medical device company focused on advancing deep brain stimulation (DBS) therapy. Founded in 2011 as a spin-out of Royal Philips Electronics, Sapiens operates from offices in Eindhoven, the Netherlands, and Munich, Germany. The company is dedicated to developing a high-resolution, MRI-compatible DBS system designed to enhance patient comfort and improve therapeutic outcomes, particularly for individuals with Parkinson's disease. Sapiens’ innovative approach includes a unique steering brain stimulation system and image-guided programming, both of which are based on patented technologies.

Visualase, Inc., established in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in the development of advanced laser and image-guided technologies for thermal ablation markets, focusing on the treatment of cancer or other malignancies using innovative laser and MRI-based guidance systems.

Covidien plc is a healthcare company involved in the development, manufacture, and sale of a wide range of products intended for clinical and home use, aimed at improving patient outcomes while reducing healthcare costs. The company operates through four primary segments: Medical Devices, Imaging Solutions, Pharmaceutical Products, and Medical Supplies. Within the Medical Devices segment, Covidien produces endomechanical instruments, soft tissue repair products, energy devices, oximetry and monitoring products, airway and ventilation products, vascular devices, and SharpSafety products. The Imaging Solutions segment focuses on radiopharmaceuticals and contrast products, while the Pharmaceutical Products segment encompasses dosage pharmaceuticals and active pharmaceutical ingredients. Finally, the Medical Supplies segment includes nursing care products and medical surgical products. Covidien collaborates with medical professionals to enhance the quality of life for patients through its innovative healthcare solutions.

Corventis is a medical technology company focused on enhancing clinical outcomes and reducing healthcare costs through the early detection of cardiovascular events. Its primary product is a non-invasive monitor that measures various aspects of heart function, enabling proactive management of cardiovascular diseases. By providing patients with tools that support an active lifestyle, Corventis aims to improve overall health while addressing critical issues in cardiovascular care.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

PowerVision, Inc. is a medical device company based in Belmont, California, focused on developing advanced intraocular lenses (IOLs) designed to restore vision for individuals affected by presbyopia and cataracts. Established in 2002, the company has created the FluidVision accommodating intraocular lens technology, which simulates the natural function of a healthy eye. This innovative lens utilizes a small amount of fluid to adjust its shape dynamically, allowing for clear vision at various distances. PowerVision aims to address the vision challenges faced by millions, particularly the over 20 million individuals in the U.S. with cataracts and the more than 90 million affected by presbyopia. The FluidVision lens represents a significant advancement in vision correction, potentially freeing patients from the need for glasses or other vision correction methods. In 2019, PowerVision was acquired by Alcon Laboratories, Inc.

TyRx is a company specializing in the design, development, and commercialization of resorbable polymeric biomaterials for medical applications. Based in Monmouth Junction, New Jersey, TyRx was founded in 1997. The company offers two primary products: PIVIT CRM, a mesh-based pouch containing antibacterial agents to protect against microbial colonization during and after the surgical implant of generators or defibrillators; and AIGISRx Flat, an antibacterial product designed to prevent infections related to implanted pacemakers and defibrillators.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology called Electrocardiographic Mapping (ECM), which generates three-dimensional images of the heart's electrical activity by integrating body surface electrical data with anatomical data obtained from CT scans. The CardioInsight system employs a single-use disposable multi-sensor vest to capture electrical signals from the body surface, enabling the creation of detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach allows physicians to visualize real-time cardiac electrical activity and enhances the accuracy of diagnosing and treating conditions such as arrhythmias and congestive heart failure. CardioInsight's technology has been validated through over 260 patient studies, demonstrating its effectiveness in guiding therapeutic interventions. Founded in 2006, the company operates as a subsidiary of Medtronic plc.

Cardiocom is a leading provider of telemedicine solutions focused on daily remote patient monitoring and disease management. The company specializes in the manufacturing and distribution of health monitoring products, including telehealth devices for conditions such as congestive heart failure, diabetes, obesity, hypertension, chronic obstructive pulmonary disease, and asthma. Cardiocom equips health professionals with home telemonitoring equipment and comprehensive telehealth services aimed at identifying symptomatic patients and facilitating early interventions to reduce unnecessary hospitalizations. The company offers tailored health monitoring options, including the Cardiocom OMNIVISOR PRO® Patient Management System, TELESCALE® for managing congestive heart failure, and COMMANDER for patients with multiple chronic conditions. Through its proactive solutions, Cardiocom enhances patient quality of life while providing cost savings to health management organizations.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.

MC10, Inc. is a company that specializes in developing wearable medical sensors designed to collect clinical-grade biometric and physiological data. Founded in 2008 and based in Lexington, Massachusetts, the company offers a range of innovative products, including BioStamp nPoint for vital signs and activity monitoring, Kintinuum for orthopedic rehabilitation, WiSP for cardiac monitoring, and BioStampMD, a conformal sensor that gathers both objective and subjective health data. MC10 employs advanced flexible electronics technology, allowing its devices to bend and stretch with the body, ensuring comfort and ease of use. The company focuses on enhancing human capabilities and improving health insights through discreet, location-specific sensing that captures real-world data on muscle activation and movement, with applications extending across various sectors including sports, military, and energy.

Kanghui was founded in 1997 and is headquartered in Changzhou. Kanghui announced today that it requested that trading of its American depositary shares on the NYSE be suspended. Kanghui has requested that the NYSE file Form 25 with the U.S. Securities and Exchange Commission (the “SEC”) notifying the SEC of the delisting of Kanghui’s American depositary shares from NYSE and the deregistration of the Company’s registered securities. Kanghui intends to terminate its reporting obligations under the Securities Exchange Act of 1934, as amended by promptly filing Form 15 with the SEC.

Mitralign is a privately held medical device company based in a suburb of Boston, Massachusetts. It specializes in developing catheter-based technologies for the percutaneous treatment of functional mitral regurgitation, a global and life-threatening cardiac condition. The company's innovative Mitralign system mimics surgical annuloplasty by delivering a series of implants directly into the mitral annulus via a catheter, reducing its size and improving valve function. Mitralign is backed by top-tier venture capitalists and has strategic investments from major cardiovascular device companies.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

Visualase, Inc., established in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in the development of advanced laser and image-guided technologies for thermal ablation markets, focusing on the treatment of cancer or other malignancies using innovative laser and MRI-based guidance systems.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology called Electrocardiographic Mapping (ECM), which generates three-dimensional images of the heart's electrical activity by integrating body surface electrical data with anatomical data obtained from CT scans. The CardioInsight system employs a single-use disposable multi-sensor vest to capture electrical signals from the body surface, enabling the creation of detailed epicardial 3D electroanatomic maps and virtual electrograms. This innovative approach allows physicians to visualize real-time cardiac electrical activity and enhances the accuracy of diagnosing and treating conditions such as arrhythmias and congestive heart failure. CardioInsight's technology has been validated through over 260 patient studies, demonstrating its effectiveness in guiding therapeutic interventions. Founded in 2006, the company operates as a subsidiary of Medtronic plc.

AcuFocus, Inc. is an ophthalmic medical device company based in Irvine, California, specializing in small aperture technologies aimed at improving near vision. Founded in 2001, the company develops and markets innovative solutions for presbyopia, including the KAMRA inlay, which helps patients restore their near vision without compromising distance vision. Additionally, AcuFocus offers the IC-8 IOL, a small aperture lens designed for cataract patients, providing a broad range of vision from near to far distances. The company also produces the AcuTarget HD, a diagnostic and surgical planning instrument that assists in the optimal treatment selection for various eye conditions such as LASIK, cataracts, and dry eye. AcuFocus distributes its products through partners across the Americas, Asia-Pacific, Europe, and the Middle East, serving both physicians and patients in the vision care market.

Functional Neuromodulation, Ltd. is a medical technology company focused on developing neuromodulation therapies for cognitive and memory disorders, particularly Alzheimer's disease and mild cognitive impairment. Founded in 2010, the company is headquartered in Minneapolis, Minnesota, with an additional office in Toronto, Canada. Its primary offering is deep brain stimulation (DBS) technology, which utilizes a surgically implanted medical device to deliver mild electrical pulses to specific areas of the brain. This approach aims to enhance neural activity and modulate the brain's memory circuits, helping patients diagnosed with Alzheimer’s and other cognitive disorders to maintain a healthier quality of life.

PowerVision, Inc. is a medical device company based in Belmont, California, focused on developing advanced intraocular lenses (IOLs) designed to restore vision for individuals affected by presbyopia and cataracts. Established in 2002, the company has created the FluidVision accommodating intraocular lens technology, which simulates the natural function of a healthy eye. This innovative lens utilizes a small amount of fluid to adjust its shape dynamically, allowing for clear vision at various distances. PowerVision aims to address the vision challenges faced by millions, particularly the over 20 million individuals in the U.S. with cataracts and the more than 90 million affected by presbyopia. The FluidVision lens represents a significant advancement in vision correction, potentially freeing patients from the need for glasses or other vision correction methods. In 2019, PowerVision was acquired by Alcon Laboratories, Inc.

PEAK Surgical is a medical device company based in Palo Alto, California, specializing in innovative surgical tools designed to enhance precision and control during surgical procedures. The company offers the PEAK Surgery System, which includes a range of disposable cutting devices that combine the accuracy of a scalpel with the bleeding control typically associated with traditional electrosurgery, minimizing collateral damage. This system is approved for use in various surgical specialties, including general, plastic and reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological procedures in the United States, as well as for general surgery in the European Union. PEAK Surgical aims to address critical needs in the surgical market by providing advanced solutions that improve patient outcomes.

Salient Surgical Technologies, Inc. is a privately held medical technology company, established in 1999, that specializes in the development and marketing of advanced energy devices for surgical applications. Initially focused on monopolar electrosurgical devices for treating liver cancers, the company has since expanded its product offerings with the AQUAMANTYS® System. This system employs patented TRANSCOLLATION® technology, which allows for the haemostatic sealing of soft tissue and bone, significantly reducing surgical blood loss. The AQUAMANTYS System, which includes a bipolar electrosurgical generator, pump system, and a range of handheld disposable devices, is utilized in various surgical fields such as orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's innovative products are distributed across the United States, Europe, and Asia, contributing to improved clinical outcomes and economic efficiencies for healthcare providers and patients alike. To date, over 500,000 patients have benefited from the use of TRANSCOLLATION technology.

Spinal Modulation, Inc., headquartered in Menlo Park, California, specializes in the development of advanced medical devices aimed at treating chronic pain. The company's flagship product, the Axium Neurostimulator System, represents a novel approach to pain management through intraspinal neuromodulation. This system specifically stimulates the dorsal root ganglion (DRG), providing an innovative alternative for patients suffering from chronic intractable leg pain and other challenging pain conditions such as those affecting the back and foot. By effectively targeting the DRG, the Axium system offers the ability to deliver adjustable therapies that can be tailored to address both broad and localized pain areas, while minimizing discomfort associated with traditional spinal cord stimulators. This technology addresses a significant unmet need in pain management, aiming to alleviate the burden on patients and healthcare systems alike.

PhysioSonics, a development-stage device company based in Washington, focuses on ultrasound imaging to monitor blood flow in the brain.

Ardian is a privately held, clinical-stage medical device company that develops catheter-based therapies for hypertension treatment and related conditions. It develops a catheter system that uses radio-frequency energy to “deactivate” sympathetic nerves in the kidneys, lowering blood pressure. The company's flagship product, the Symplicity Catheter System, addresses uncontrolled hypertension through renal denervation, or ablation of the nerves lining the renal arteries. It has received the CE (Conformité Européene) mark and Australia's Therapeutic Goods Administration (TGA) listing but is not yet approved by the U.S. Food and Drug Administration (FDA).

Osteotech is focused on the development, manufacturing, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgeries. It facilitates spinal, trauma, and total joint revision procedures. Osteotech was acquired by Medtronic in November 2010. It was founded in 1986 in Eatontown, New Jersey.

Intersect ENT, Inc. is a medical device company focused on developing innovative therapies for patients with ear, nose, and throat conditions. Founded in 2003 and headquartered in Menlo Park, California, the company specializes in drug delivery products aimed at enhancing treatment outcomes for chronic sinusitis and other related ailments. Its key offerings include the PROPEL and PROPEL mini drug-releasing implants, designed for patients undergoing sinus surgery, as well as the PROPEL Contour implant, which targets frontal and maxillary sinus ostia. Additionally, Intersect ENT provides SINUVA, a steroid-releasing implant intended for use in a physician office setting to address refractory disease. The company was previously known as Sinexus, Inc. before rebranding in 2009.