U.S. Venture Partners

U.S. Venture Partners is a Menlo Park-based venture capital firm established in 1981 that concentrates on early-stage and growth investments in technology and healthcare. The firm backs business-to-business software, IT security, consumer internet, mobile, e-commerce, and IT-enabled healthcare services, as well as digital health, cloud technology, and life sciences including oncology. Its focus spans enterprise software, cybersecurity, healthcare IT, SaaS, manufacturing, and related sectors on the West Coast. The team comprises former entrepreneurs, technologists, executives, and industry experts who help portfolio companies scale and reach customers.

Dale Holladay

CFO

Past deals in Series F

MicroTransponder

Series F in 2025
MicroTransponder is a medical device company that develops and commercializes implantable neurostimulation platforms aimed at treating neurological conditions. The company focuses on vagus nerve stimulation to promote neuroplasticity and functional recovery, with products including the Serenity System for tinnitus and Vivistim, an FDA-approved therapy for ischemic stroke survivors with moderate to severe upper-limb impairment more than six months post-stroke. Founded in 2007 and headquartered in Austin, Texas, MicroTransponder's technology combines paired vagus nerve stimulation with wireless delivery of targeted electrical impulses to enhance recovery after neurological injury and disease.

Route 92

Series F in 2024
Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

Route 92

Series F in 2023
Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

HeartFlow

Series F in 2023
HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.

Zerto

Series F in 2020
Zerto is a company that specializes in providing enterprise-class disaster recovery and business continuity software solutions. Founded in 2009 and headquartered in Boston, Massachusetts with additional offices globally, Zerto focuses on keeping IT infrastructure running continuously for both enterprises and cloud environments. Its flagship product, Zerto Virtual Replication, enables the protection, recovery, and migration of applications across various cloud and virtualized data centers. The company's BC/DR Platform offers disaster recovery as a service for public, private, and hybrid clouds, catering to industries such as healthcare, legal, and financial services.

Inspire Medical Systems

Series F in 2016
Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

Electric Cloud

Series F in 2016
Electric Cloud, Inc. is a software company that specializes in release automation and continuous delivery solutions for organizations globally. Founded in 2002 and based in San Jose, California, the company offers products such as ElectricFlow, an adaptive release orchestration platform that facilitates control over releases at any scale, and Electric Accelerator, which optimizes build and test processes by distributing workloads across various resources. Electric Cloud serves a diverse range of industries, including financial services, automotive, and Internet of Things, helping clients like Cisco, Intel, and Lockheed Martin enhance their DevOps productivity. By automating and streamlining the software delivery process, Electric Cloud enables organizations to reduce costs and risks associated with software releases, ultimately improving time-to-market, developer productivity, and software quality. As of April 2019, Electric Cloud operates as a subsidiary of CloudBees, Inc.

Xirrus

Series F in 2013
Xirrus, Inc., established in 2004 and headquartered in Thousand Oaks, California, specializes in wireless access network solutions. It offers a range of products including high-density and outdoor access points, wired switches, network accessories like enclosures and mountings, and power options. Xirrus also provides software solutions such as the Xirrus Management System for network deployment and management, EasyPass Personal Wi-Fi for secure public Wi-Fi access, Wi-Fi Designer for predictive heat-map network design, and XA4 for high-density user experiences in large venues. Serving clients across enterprise, education, healthcare, hospitality, and other markets both domestically and internationally, Xirrus operates as a subsidiary of Riverbed Technology, Inc., focusing on delivering robust wireless networking solutions.

Force10 Networks

Series F in 2006
Force10 Networks, Inc. is a manufacturer of networking equipment and solutions that cater to data center and network deployment needs. The company operates primarily in two segments: Ethernet and Transport. The Ethernet segment includes 1 GbE and 10GbE switches and routers designed for data centers, enterprises, and service providers, while the Transport segment offers products for metro and inter-office optical networks, wireless aggregation, and converged business access networks. Force10 is recognized for its high-performance data center solutions, which are built on open, standards-based hardware and software, enabling clients to achieve scalability, reliability, and application awareness. The company's products are marketed through a direct sales force in the United States and through various international channel partners. Founded in 1999 and based in San Jose, California, Force10 Networks operates as a subsidiary of Dell Marketing L.P.

RelayHealth

Series F in 2004
RelayHealth is a provider of online healthcare communication services that facilitates secure and convenient information exchange among various healthcare stakeholders, including patients, providers, pharmacies, payors, and pharmaceutical manufacturers. The company offers a range of services such as ePrescribing, online refills, access to lab results, reimbursable online visits, and online bill payments. By enabling consistent connectivity among medical companies, doctors, and patients, RelayHealth aims to streamline interactions within the healthcare system. This connectivity ultimately contributes to improved patient care, faster access to necessary services, reduced costs, and enhanced operational efficiency for healthcare providers.
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