U.S. Venture Partners

HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.

MicroTransponder is a medical device company that develops and commercializes implantable neurostimulation platforms aimed at treating neurological conditions. The company focuses on vagus nerve stimulation to promote neuroplasticity and functional recovery, with products including the Serenity System for tinnitus and Vivistim, an FDA-approved therapy for ischemic stroke survivors with moderate to severe upper-limb impairment more than six months post-stroke. Founded in 2007 and headquartered in Austin, Texas, MicroTransponder's technology combines paired vagus nerve stimulation with wireless delivery of targeted electrical impulses to enhance recovery after neurological injury and disease.

Shoulder Innovations designs and manufactures medical devices for shoulder replacement surgery, focusing on inset glenoid fixation technology to provide a stable glenoid platform and reliable fixation. Its product portfolio includes InSet Total Shoulder Arthroplasty, InSet Reverse Shoulder Arthroplasty, ProVoyance Shoulder Planning Software, and InSet Tray System, along with associated instrumentation. The company distributes its products through partners in the United States and aims to reduce operative time and overall healthcare costs while improving post-surgical implant stability. Founded in 2009, the company is based in Holland, Michigan.

Nervonik is a medical device company developing an opioid-free peripheral nerve stimulation system and a neuro-modulation device with miniaturized sensing feedback for closed-loop therapy, aimed at treating chronic neuropathic pain. The company focuses on advancing clinical research and achieving regulatory milestones to bring its therapies to market.

Okami Medical, Inc. is a medical device manufacturer based in Aliso Viejo, California, specializing in the occlusion of peripheral vessels to treat cardiovascular disease. The company's flagship product, the LOw-profile Braided Occluder (LOBO), is designed to provide interventional physicians with a single, versatile device for occluding various arterial targets without the need for multiple embolic devices. The LOBO system features a patented design and proprietary HDBRAID technology, which creates a highly occlusive pore structure that effectively reduces blood flow and accelerates vessel closure. Founded in 2011, Okami Medical aims to meet the evolving needs of patients and healthcare providers by offering innovative solutions that ensure rapid and reliable vessel occlusion, regardless of anatomical challenges.

Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

Carlsmed specializes in medical technology for spine surgery, offering the aprevo™ system, an FDA-designated breakthrough technology for personalized lumbar fusion surgery. Headquartered in San Diego, California, Carlsmed was founded in 2018.

Cagent Vascular, LLC is a medical device company that specializes in developing innovative angioplasty balloons utilizing proprietary serration technology. Incorporated in 2014 and based in Wayne, Pennsylvania, the company has created the Serranator, a unique angioplasty device featuring serrated metal strips embedded in a semi-compliant balloon. This device is designed to treat atherosclerosis by effectively addressing blocked arteries, particularly in patients with peripheral artery disease and chronic limb-threatening ischemia. Cagent Vascular's technology aims to enhance the effectiveness of vessel dilatation procedures in cardiovascular interventions, providing healthcare providers with advanced tools to improve patient outcomes.

Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

Luminopia is a company focused on developing innovative treatments for significant neuro-visual disorders, particularly amblyopia, commonly known as lazy eye, which is a leading cause of vision loss in children. By creating engaging digital therapeutics, Luminopia aims to provide effective solutions that are rigorously evaluated for FDA approval. Their flagship product, Luminopia One, leverages binocular vision techniques to address amblyopia, enabling healthcare professionals to offer new treatment options for affected patients. Partnering with Boston Children’s Hospital, Luminopia is at the forefront of pioneering advanced therapeutic approaches that enhance patient care in the field of pediatric vision health.

HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.

Shoulder Innovations designs and manufactures medical devices for shoulder replacement surgery, focusing on inset glenoid fixation technology to provide a stable glenoid platform and reliable fixation. Its product portfolio includes InSet Total Shoulder Arthroplasty, InSet Reverse Shoulder Arthroplasty, ProVoyance Shoulder Planning Software, and InSet Tray System, along with associated instrumentation. The company distributes its products through partners in the United States and aims to reduce operative time and overall healthcare costs while improving post-surgical implant stability. Founded in 2009, the company is based in Holland, Michigan.

MicroTransponder is a medical device company that develops and commercializes implantable neurostimulation platforms aimed at treating neurological conditions. The company focuses on vagus nerve stimulation to promote neuroplasticity and functional recovery, with products including the Serenity System for tinnitus and Vivistim, an FDA-approved therapy for ischemic stroke survivors with moderate to severe upper-limb impairment more than six months post-stroke. Founded in 2007 and headquartered in Austin, Texas, MicroTransponder's technology combines paired vagus nerve stimulation with wireless delivery of targeted electrical impulses to enhance recovery after neurological injury and disease.

Carlsmed specializes in medical technology for spine surgery, offering the aprevo™ system, an FDA-designated breakthrough technology for personalized lumbar fusion surgery. Headquartered in San Diego, California, Carlsmed was founded in 2018.

Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

Standard Bariatrics is a medical device company based in Cincinnati, Ohio, specializing in the development of surgical instruments for weight-loss surgeries, particularly laparoscopic sleeve gastrectomy. Founded in 2014, the company has created a series of disposable surgical tools designed to work alongside general-use endoscopic staplers. These innovative tools help surgeons standardize their techniques, reduce variability, and minimize waste during procedures. By decreasing the number of cartridges needed for each surgery, Standard Bariatrics enables healthcare providers to lower costs while ensuring consistent surgical outcomes.

Neuros Medical, Inc. is a neuromodulation company dedicated to developing innovative therapies to address unmet medical needs for patients globally. Founded in 2008 and headquartered in Willoughby Hills, Ohio, the company specializes in its proprietary platform technology known as Electrical Nerve Block. This technology is designed to eliminate chronic pain across various conditions, including neuroma/residual limb pain, chronic post-surgical pain, and chronic migraine. The Neuros Altius System, one of its key products, includes an implantable generator with an integrated rechargeable battery, a cuff electrode, and external devices, further demonstrating the company's commitment to advancing pain management solutions.

Carlsmed specializes in medical technology for spine surgery, offering the aprevo™ system, an FDA-designated breakthrough technology for personalized lumbar fusion surgery. Headquartered in San Diego, California, Carlsmed was founded in 2018.

Shoulder Innovations designs and manufactures medical devices for shoulder replacement surgery, focusing on inset glenoid fixation technology to provide a stable glenoid platform and reliable fixation. Its product portfolio includes InSet Total Shoulder Arthroplasty, InSet Reverse Shoulder Arthroplasty, ProVoyance Shoulder Planning Software, and InSet Tray System, along with associated instrumentation. The company distributes its products through partners in the United States and aims to reduce operative time and overall healthcare costs while improving post-surgical implant stability. Founded in 2009, the company is based in Holland, Michigan.

Silverback Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Seattle, Washington, specializing in the development of tissue-targeted therapeutics aimed at treating cancer, chronic viral infections, and other serious diseases. The company’s lead product candidate, SBT6050, is currently in a Phase I/Ib clinical trial and is designed as a TLR8 agonist linker-payload conjugated to a HER2-directed monoclonal antibody, targeting tumors such as breast and non-small cell lung cancers. Silverback is also advancing SBT6290, a preclinical candidate targeting Nectin4 in various cancers, and SBT8230, which aims to treat chronic hepatitis B virus infection. The company employs its proprietary ImmunoTAC technology platform to create therapies that can be systemically administered while acting specifically at disease sites, thereby potentially modulating fundamental disease pathways previously considered inaccessible. Founded in 2016, Silverback Therapeutics is committed to innovative approaches in biopharmaceutical development.

Medigate by Claroty is a developer of a medical device security platform that safeguards healthcare provider networks from cyber threats. Founded in 2017, the company is headquartered in New York City and focuses on protecting all connected medical devices within these networks. Its platform utilizes deep packet inspection to decode proprietary healthcare IoT protocols, providing visibility and security for IoT and medical devices. By offering threat detection and attack prevention services, Medigate enhances the safety and privacy of hospital environments, allowing for the secure deployment of both existing and new medical devices.

Vivo Care develops a remote care software platform that supports remote patient monitoring and chronic disease management. The platform integrates patient-centered monitoring technology, connected devices, and clinical support to help healthcare providers deliver equitable care across diverse patient populations, improve patient outcomes, and modernize the patient experience. It enables scalable deployment of RPM and chronic care management programs, enhances patient engagement, and aims to deliver compliant and reliable reimbursement revenue for providers, supporting both clinical and financial results.

Okami Medical, Inc. is a medical device manufacturer based in Aliso Viejo, California, specializing in the occlusion of peripheral vessels to treat cardiovascular disease. The company's flagship product, the LOw-profile Braided Occluder (LOBO), is designed to provide interventional physicians with a single, versatile device for occluding various arterial targets without the need for multiple embolic devices. The LOBO system features a patented design and proprietary HDBRAID technology, which creates a highly occlusive pore structure that effectively reduces blood flow and accelerates vessel closure. Founded in 2011, Okami Medical aims to meet the evolving needs of patients and healthcare providers by offering innovative solutions that ensure rapid and reliable vessel occlusion, regardless of anatomical challenges.

Silverback Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Seattle, Washington, specializing in the development of tissue-targeted therapeutics aimed at treating cancer, chronic viral infections, and other serious diseases. The company’s lead product candidate, SBT6050, is currently in a Phase I/Ib clinical trial and is designed as a TLR8 agonist linker-payload conjugated to a HER2-directed monoclonal antibody, targeting tumors such as breast and non-small cell lung cancers. Silverback is also advancing SBT6290, a preclinical candidate targeting Nectin4 in various cancers, and SBT8230, which aims to treat chronic hepatitis B virus infection. The company employs its proprietary ImmunoTAC technology platform to create therapies that can be systemically administered while acting specifically at disease sites, thereby potentially modulating fundamental disease pathways previously considered inaccessible. Founded in 2016, Silverback Therapeutics is committed to innovative approaches in biopharmaceutical development.

Omada Health is a digital healthcare company that offers personalized programs to manage chronic conditions such as prediabetes, diabetes, hypertension, musculoskeletal issues, and behavioral health. It combines professional coaching, connected devices, real-time data, and personalized feedback to deliver clinically meaningful results.

Nuvaira, Inc. is a medical device company based in Minneapolis, Minnesota, focused on developing innovative treatments for obstructive lung diseases, particularly chronic obstructive pulmonary disease (COPD). Founded in 2008, Nuvaira specializes in a novel catheter-based Lung Denervation System that aims to address airway nerve hyperactivity by targeting the parasympathetic innervation of the lungs. This minimally invasive procedure is designed to improve lung function, enhance exercise capacity, and elevate the quality of life for patients suffering from chronic respiratory conditions. With a commitment to advancing treatment options, Nuvaira seeks to reduce the clinical consequences associated with neural hyperactivity in conditions such as COPD and asthma.

Medigate by Claroty is a developer of a medical device security platform that safeguards healthcare provider networks from cyber threats. Founded in 2017, the company is headquartered in New York City and focuses on protecting all connected medical devices within these networks. Its platform utilizes deep packet inspection to decode proprietary healthcare IoT protocols, providing visibility and security for IoT and medical devices. By offering threat detection and attack prevention services, Medigate enhances the safety and privacy of hospital environments, allowing for the secure deployment of both existing and new medical devices.

HighLife is a medical technology company specializing in Transcatheter Mitral Valve Replacement (TMVR) aimed at treating mitral valve regurgitation. Founded in 2010 by Georg Börtlein, the company is developing a minimally invasive prosthetic mitral valve designed to be implanted on a beating heart, allowing for the preservation of the native valve structure and surrounding anatomy. HighLife's innovative system facilitates a transseptal delivery through the femoral vein, enabling a reversible approach that minimizes trauma to patients during surgical procedures. The technology is currently undergoing clinical evaluation, with a focus on ensuring ease and safety of use for healthcare providers.

NeoChord, Inc. is a medical technology company based in St. Louis Park, Minnesota, specializing in innovative solutions for degenerative mitral valve disease (DMR). Founded in 2007, the company has developed the NeoChord Artificial Chordae Delivery System, a proprietary device that enables mitral valve repair to be performed while the heart is still beating. This minimally invasive technique involves a small incision, significantly reducing recovery time and complications compared to traditional procedures that require larger chest incisions and stopping the heart. NeoChord's system addresses severe mitral regurgitation caused by elongated or ruptured chordae tendineae, allowing surgeons to effectively manage blood flow without the need for cardiopulmonary bypass.

Inari Medical, Inc. is a commercial-stage medical device company based in Irvine, California, that specializes in developing innovative products for the treatment of venous diseases. Founded in 2011, the company's primary focus is on venous thromboembolism, which it addresses through two key devices: the ClotTriever and the FlowTriever. The ClotTriever is designed for the minimally invasive removal of blood clots from peripheral blood vessels, specifically targeting patients with deep vein thrombosis. Meanwhile, the FlowTriever system effectively treats pulmonary embolism by removing large clots from major blood vessels without the need for thrombolytic drugs. Inari Medical primarily generates its revenue from the United States while also reaching international markets.

Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.

Neuros Medical, Inc. is a neuromodulation company dedicated to developing innovative therapies to address unmet medical needs for patients globally. Founded in 2008 and headquartered in Willoughby Hills, Ohio, the company specializes in its proprietary platform technology known as Electrical Nerve Block. This technology is designed to eliminate chronic pain across various conditions, including neuroma/residual limb pain, chronic post-surgical pain, and chronic migraine. The Neuros Altius System, one of its key products, includes an implantable generator with an integrated rechargeable battery, a cuff electrode, and external devices, further demonstrating the company's commitment to advancing pain management solutions.

Omada Health is a digital healthcare company that offers personalized programs to manage chronic conditions such as prediabetes, diabetes, hypertension, musculoskeletal issues, and behavioral health. It combines professional coaching, connected devices, real-time data, and personalized feedback to deliver clinically meaningful results.

Route 92 Medical, established in 2015 and headquartered in San Mateo, California, specializes in the development of innovative medical devices for stroke treatment. Their flagship product is a stealthy catheter designed for rapid and efficient removal of blood clots during acute ischemic stroke, aiming to improve patient outcomes and enhance recovery. Additionally, the company offers a rapid aspiration thrombectomy system and an intra-cerebral implant delivery system, further expanding their capabilities in stroke care.

Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.

SentreHEART, Inc., located in Redwood City, California, is a privately held medical device company specializing in catheter-based technologies for suturing soft tissues. The company has developed the LARIAT Suture Delivery Device, which allows physicians to remotely deliver a 40mm pre-tied suture loop for effective soft tissue closure through minimally invasive access points as small as 4.3mm. This innovative technology eliminates the need for metal, clips, or fabrics, ensuring a complete and immediate closure without leaving foreign materials in the body. SentreHEART has received regulatory clearance for its device for soft tissue ligation and approximation in the United States, Europe, and Canada, enhancing surgical options and patient safety by reducing the risk of thromboembolism.

Omada Health is a digital healthcare company that offers personalized programs to manage chronic conditions such as prediabetes, diabetes, hypertension, musculoskeletal issues, and behavioral health. It combines professional coaching, connected devices, real-time data, and personalized feedback to deliver clinically meaningful results.

ReShape Lifesciences is a medical device company focused on technologies to treat obesity and metabolic diseases. The company develops and commercializes products designed to provide less invasive options for weight loss, including the Lap-Band System, an adjustable gastric banding device for long-term obesity management. It also has the ReShape Vest system, an investigational laparoscopically implanted device that wraps around the stomach and is designed to support weight loss without permanent changes to the GI tract; the Vest is primarily marketed outside the United States. The company traces its origins to EnteroMedics and adopted the ReShape Lifesciences name in 2017. It is headquartered in San Clemente, California, and operates in multiple international markets.

Inari Medical, Inc. is a commercial-stage medical device company based in Irvine, California, that specializes in developing innovative products for the treatment of venous diseases. Founded in 2011, the company's primary focus is on venous thromboembolism, which it addresses through two key devices: the ClotTriever and the FlowTriever. The ClotTriever is designed for the minimally invasive removal of blood clots from peripheral blood vessels, specifically targeting patients with deep vein thrombosis. Meanwhile, the FlowTriever system effectively treats pulmonary embolism by removing large clots from major blood vessels without the need for thrombolytic drugs. Inari Medical primarily generates its revenue from the United States while also reaching international markets.

Omada Health is a digital healthcare company that offers personalized programs to manage chronic conditions such as prediabetes, diabetes, hypertension, musculoskeletal issues, and behavioral health. It combines professional coaching, connected devices, real-time data, and personalized feedback to deliver clinically meaningful results.

Sequent Medical is a privately-held medical device company focused on developing innovative catheter-based neurovascular technologies. Founded in 2006, the company is headquartered in Aliso Viejo, California, with additional operations in Bonn, Germany. Sequent Medical has invented and developed Microbraid technology to create the WEB Aneurysm Embolization System, a versatile treatment option for both ruptured and unruptured intracranial aneurysms. The WEB system has received CE mark approval and has been used to treat nearly 600 aneurysms in Europe, Latin America, and New Zealand. However, it is not available for sale or use in the United States.

Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.

Inari Medical, Inc. is a commercial-stage medical device company based in Irvine, California, that specializes in developing innovative products for the treatment of venous diseases. Founded in 2011, the company's primary focus is on venous thromboembolism, which it addresses through two key devices: the ClotTriever and the FlowTriever. The ClotTriever is designed for the minimally invasive removal of blood clots from peripheral blood vessels, specifically targeting patients with deep vein thrombosis. Meanwhile, the FlowTriever system effectively treats pulmonary embolism by removing large clots from major blood vessels without the need for thrombolytic drugs. Inari Medical primarily generates its revenue from the United States while also reaching international markets.

Neoconix, Inc. is a supplier of low-profile, high-performance electrical connectors catering to mobile, enterprise IT, and industrial markets. Founded in 2002 and based in San Jose, California, the company specializes in miniaturized connectors that leverage its patented PCBeam technology. This technology utilizes standard printed circuit lithographic processes, enabling rapid development and competitive pricing for custom electrical connector solutions. Neoconix offers a diverse range of products, including standard mobile and consumer connectors, high-speed connectors, and various custom connector options for applications in computing, telecommunications, consumer electronics, military-aerospace, medical devices, and test equipment. With over 60 patents issued or pending, Neoconix is recognized for delivering some of the industry's lowest profile connectors, achieving high reliability and extreme performance exceeding 25Gb/s. The company was previously known as Epic Technology, Inc. before adopting its current name in December 2004.

NanoStim is an early-stage medical device company focused on developing a miniaturized, leadless cardiac pacemaker aimed at reducing complications associated with traditional pacemakers, which affect over 100,000 individuals annually. The company has assembled a highly skilled team of medical device engineers to advance this innovative technology, which is designed for direct implantation in a cardiac chamber without the need for leads. By offering a leadless pacing solution, NanoStim seeks to improve patient outcomes and enhance the safety and effectiveness of cardiac interventions.

AtheroMed, Inc. is a medical device company based in Menlo Park, California, which specializes in developing catheter-based treatments for peripheral arterial disease (PAD). Founded in 2006, AtheroMed's innovative systems address a range of vessel sizes, from small arteries at the ankle to larger ones above the knee. The company aims to improve patient outcomes through its targeted therapies, facilitating more effective treatment options for individuals suffering from PAD.

ApniCure, Inc. is a medical device company based in Redwood City, California, established in 2005. The company specializes in developing and commercializing innovative home-use devices that utilize its proprietary Oral Pressure Therapy (OPT) platform technology. ApniCure focuses on addressing obstructive sleep apnea (OSA) and other sleep-related disorders. It has received 510(k) clearance from the U.S. Food and Drug Administration to market its Winx® Sleep Therapy System in the United States, offering patients a home-use treatment option for OSA. By providing effective sleep therapies, ApniCure aims to enhance the quality of life for millions of individuals affected by sleep disordered breathing.

Omada Health is a digital healthcare company that offers personalized programs to manage chronic conditions such as prediabetes, diabetes, hypertension, musculoskeletal issues, and behavioral health. It combines professional coaching, connected devices, real-time data, and personalized feedback to deliver clinically meaningful results.

Founded in 2003, Intersect ENT is a medical device company based in Menlo Park, California. It specializes in developing innovative therapies for Ear, Nose, and Throat surgeons to enhance patient care, focusing on treatments for chronic rhinosinusitis.

ReShape Lifesciences is a medical device company focused on technologies to treat obesity and metabolic diseases. The company develops and commercializes products designed to provide less invasive options for weight loss, including the Lap-Band System, an adjustable gastric banding device for long-term obesity management. It also has the ReShape Vest system, an investigational laparoscopically implanted device that wraps around the stomach and is designed to support weight loss without permanent changes to the GI tract; the Vest is primarily marketed outside the United States. The company traces its origins to EnteroMedics and adopted the ReShape Lifesciences name in 2017. It is headquartered in San Clemente, California, and operates in multiple international markets.

NanoStim is an early-stage medical device company focused on developing a miniaturized, leadless cardiac pacemaker aimed at reducing complications associated with traditional pacemakers, which affect over 100,000 individuals annually. The company has assembled a highly skilled team of medical device engineers to advance this innovative technology, which is designed for direct implantation in a cardiac chamber without the need for leads. By offering a leadless pacing solution, NanoStim seeks to improve patient outcomes and enhance the safety and effectiveness of cardiac interventions.

Neoconix, Inc. is a supplier of low-profile, high-performance electrical connectors catering to mobile, enterprise IT, and industrial markets. Founded in 2002 and based in San Jose, California, the company specializes in miniaturized connectors that leverage its patented PCBeam technology. This technology utilizes standard printed circuit lithographic processes, enabling rapid development and competitive pricing for custom electrical connector solutions. Neoconix offers a diverse range of products, including standard mobile and consumer connectors, high-speed connectors, and various custom connector options for applications in computing, telecommunications, consumer electronics, military-aerospace, medical devices, and test equipment. With over 60 patents issued or pending, Neoconix is recognized for delivering some of the industry's lowest profile connectors, achieving high reliability and extreme performance exceeding 25Gb/s. The company was previously known as Epic Technology, Inc. before adopting its current name in December 2004.

Articulinx, Inc. is a medical device company based in Cupertino, California, established in 2007. The company specializes in the development and manufacturing of minimally-invasive implants and devices aimed at treating hand osteoarthritis. Articulinx's products are designed to restore joint mobility and alleviate joint pain, thereby reducing the need for more invasive surgical interventions. The company primarily serves the orthopedic, extremities, and small joints markets in the United States. Through its innovative offerings, Articulinx seeks to enhance patient outcomes and improve the quality of life for individuals suffering from joint pain.

Aptus Endosystems, Inc. is a medical device company focused on developing advanced solutions for endovascular aneurysm repair (EVAR). Founded in 2002 and based in Sunnyvale, California, the company has created innovative technologies such as the Heli-FX EndoAnchor system, which provides a durable method for treating abdominal and thoracic aortic aneurysms. This system employs unique helical staple technology that allows for independent fixation of endografts, mimicking the precision of open surgical suturing while facilitating minimally invasive procedures. Additionally, Aptus Endosystems offers the Aptus TourGuide, a steerable sheath designed to enhance access and delivery of peripheral vascular products. The company's products are distributed in key markets including the United States and several European countries, and the Aptus Endovascular AAA Repair Systems hold CE Marking for distribution within the European Union.

SentreHEART, Inc., located in Redwood City, California, is a privately held medical device company specializing in catheter-based technologies for suturing soft tissues. The company has developed the LARIAT Suture Delivery Device, which allows physicians to remotely deliver a 40mm pre-tied suture loop for effective soft tissue closure through minimally invasive access points as small as 4.3mm. This innovative technology eliminates the need for metal, clips, or fabrics, ensuring a complete and immediate closure without leaving foreign materials in the body. SentreHEART has received regulatory clearance for its device for soft tissue ligation and approximation in the United States, Europe, and Canada, enhancing surgical options and patient safety by reducing the risk of thromboembolism.

Castlight Health is dedicated to simplifying the healthcare experience and promoting healthier, more productive lives. Its health navigation platform integrates with various health vendors, benefits resources, and plan designs, creating a comprehensive application that addresses diverse health needs. By tailoring guidance to individual profiles, Castlight assists users, whether they are healthy, managing chronic conditions, or seeking medical care, in accessing optimal resources. The company aims to help organizations manage rising healthcare costs and enhance the value of their benefits investments. Since its inception, Castlight has introduced innovative solutions such as data-driven price transparency tools and a consumer-friendly wellbeing platform. Currently, it serves millions of users and partners with numerous large employers, positioning itself as a key player in the healthcare sector. Castlight is headquartered in San Francisco.

AtheroMed, Inc. is a medical device company based in Menlo Park, California, which specializes in developing catheter-based treatments for peripheral arterial disease (PAD). Founded in 2006, AtheroMed's innovative systems address a range of vessel sizes, from small arteries at the ankle to larger ones above the knee. The company aims to improve patient outcomes through its targeted therapies, facilitating more effective treatment options for individuals suffering from PAD.

Sequent Medical is a privately-held medical device company focused on developing innovative catheter-based neurovascular technologies. Founded in 2006, the company is headquartered in Aliso Viejo, California, with additional operations in Bonn, Germany. Sequent Medical has invented and developed Microbraid technology to create the WEB Aneurysm Embolization System, a versatile treatment option for both ruptured and unruptured intracranial aneurysms. The WEB system has received CE mark approval and has been used to treat nearly 600 aneurysms in Europe, Latin America, and New Zealand. However, it is not available for sale or use in the United States.

Calithera Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule drugs targeting tumor metabolism and immunology for cancer treatment. Headquartered in South San Francisco, California, the company’s lead product candidate, CB-839, is an inhibitor of glutaminase currently in Phase II clinical trials for solid tumors. Additionally, Calithera is developing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology, as well as CB-280, another oral arginase inhibitor aimed at treating cystic fibrosis, and CB-708, an orally administered small molecule inhibitor of CD73. The company has established collaborations with Bristol-Myers Squibb to evaluate the combination of nivolumab with CB-839, and with Incyte Corporation for the development and commercialization of INCB001158. Founded in 2010, Calithera Biosciences is dedicated to advancing innovative therapies that specifically target critical pathways in tumor growth and survival.

CardioKinetix develops transcatheter implants for treating heart failure. Its flagship product is Parachute, a ventricular partitioning device designed to improve overall cardiac function in patients who have experienced a heart attack. The company serves customers primarily in the United States and Europe.

Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.

Founded in 2003, Intersect ENT is a medical device company based in Menlo Park, California. It specializes in developing innovative therapies for Ear, Nose, and Throat surgeons to enhance patient care, focusing on treatments for chronic rhinosinusitis.

Aptus Endosystems, Inc. is a medical device company focused on developing advanced solutions for endovascular aneurysm repair (EVAR). Founded in 2002 and based in Sunnyvale, California, the company has created innovative technologies such as the Heli-FX EndoAnchor system, which provides a durable method for treating abdominal and thoracic aortic aneurysms. This system employs unique helical staple technology that allows for independent fixation of endografts, mimicking the precision of open surgical suturing while facilitating minimally invasive procedures. Additionally, Aptus Endosystems offers the Aptus TourGuide, a steerable sheath designed to enhance access and delivery of peripheral vascular products. The company's products are distributed in key markets including the United States and several European countries, and the Aptus Endovascular AAA Repair Systems hold CE Marking for distribution within the European Union.

Calithera Biosciences, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule drugs targeting tumor metabolism and immunology for cancer treatment. Headquartered in South San Francisco, California, the company’s lead product candidate, CB-839, is an inhibitor of glutaminase currently in Phase II clinical trials for solid tumors. Additionally, Calithera is developing INCB001158, an oral arginase inhibitor in Phase I/II trials for hematology and oncology, as well as CB-280, another oral arginase inhibitor aimed at treating cystic fibrosis, and CB-708, an orally administered small molecule inhibitor of CD73. The company has established collaborations with Bristol-Myers Squibb to evaluate the combination of nivolumab with CB-839, and with Incyte Corporation for the development and commercialization of INCB001158. Founded in 2010, Calithera Biosciences is dedicated to advancing innovative therapies that specifically target critical pathways in tumor growth and survival.

Castlight Health is dedicated to simplifying the healthcare experience and promoting healthier, more productive lives. Its health navigation platform integrates with various health vendors, benefits resources, and plan designs, creating a comprehensive application that addresses diverse health needs. By tailoring guidance to individual profiles, Castlight assists users, whether they are healthy, managing chronic conditions, or seeking medical care, in accessing optimal resources. The company aims to help organizations manage rising healthcare costs and enhance the value of their benefits investments. Since its inception, Castlight has introduced innovative solutions such as data-driven price transparency tools and a consumer-friendly wellbeing platform. Currently, it serves millions of users and partners with numerous large employers, positioning itself as a key player in the healthcare sector. Castlight is headquartered in San Francisco.

Sequent Medical is a privately-held medical device company focused on developing innovative catheter-based neurovascular technologies. Founded in 2006, the company is headquartered in Aliso Viejo, California, with additional operations in Bonn, Germany. Sequent Medical has invented and developed Microbraid technology to create the WEB Aneurysm Embolization System, a versatile treatment option for both ruptured and unruptured intracranial aneurysms. The WEB system has received CE mark approval and has been used to treat nearly 600 aneurysms in Europe, Latin America, and New Zealand. However, it is not available for sale or use in the United States.

Articulinx, Inc. is a medical device company based in Cupertino, California, established in 2007. The company specializes in the development and manufacturing of minimally-invasive implants and devices aimed at treating hand osteoarthritis. Articulinx's products are designed to restore joint mobility and alleviate joint pain, thereby reducing the need for more invasive surgical interventions. The company primarily serves the orthopedic, extremities, and small joints markets in the United States. Through its innovative offerings, Articulinx seeks to enhance patient outcomes and improve the quality of life for individuals suffering from joint pain.

Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.

ReShape Lifesciences is a medical device company focused on technologies to treat obesity and metabolic diseases. The company develops and commercializes products designed to provide less invasive options for weight loss, including the Lap-Band System, an adjustable gastric banding device for long-term obesity management. It also has the ReShape Vest system, an investigational laparoscopically implanted device that wraps around the stomach and is designed to support weight loss without permanent changes to the GI tract; the Vest is primarily marketed outside the United States. The company traces its origins to EnteroMedics and adopted the ReShape Lifesciences name in 2017. It is headquartered in San Clemente, California, and operates in multiple international markets.

ReShape Lifesciences is a medical device company focused on technologies to treat obesity and metabolic diseases. The company develops and commercializes products designed to provide less invasive options for weight loss, including the Lap-Band System, an adjustable gastric banding device for long-term obesity management. It also has the ReShape Vest system, an investigational laparoscopically implanted device that wraps around the stomach and is designed to support weight loss without permanent changes to the GI tract; the Vest is primarily marketed outside the United States. The company traces its origins to EnteroMedics and adopted the ReShape Lifesciences name in 2017. It is headquartered in San Clemente, California, and operates in multiple international markets.

Lutonix DCB is a new drug-coated balloon catheter that delivers paclitaxel to the arterial wall in a single, short inflation. Paclitaxel is an anti-proliferative drug commonly used to prevent arterial restenosis. Lutonix DCB is very similar to a standard angioplasty balloon, but contains a special coating consisting of paclitaxel and a proprietary carrier that facilitates the drug’s transfer to the arterial wall upon inflation. This highly efficient formulation allows Lutonix DCB to deliver a therapeutic dose to the artery wall, while keeping the dose of paclitaxel on the balloon as low as possible. A lower balloon drug load minimizes systemic drug exposure and is designed to maximize safety.

Valeritas Holdings, Inc. was a medical technology company focused on developing and commercializing innovative solutions for the treatment of Type 2 diabetes. Founded in 2006 and headquartered in Bridgewater, New Jersey, the company offered the V-Go, a wearable insulin delivery device designed for basal-bolus therapy, allowing patients to manage their insulin intake conveniently and discreetly. Valeritas was also working on additional products, including the V-Go Prefill, aimed at simplifying the device-filling process, and V-Go SIM, which would facilitate real-time tracking of dosing utilization. The company marketed its products through third-party wholesalers and medical supply distributors, aiming to enhance the health and quality of life for individuals living with diabetes. However, on June 30, 2020, Valeritas Holdings filed for Chapter 11 bankruptcy, leading to its cessation of operations.

CardioKinetix develops transcatheter implants for treating heart failure. Its flagship product is Parachute, a ventricular partitioning device designed to improve overall cardiac function in patients who have experienced a heart attack. The company serves customers primarily in the United States and Europe.

Founded in 2003, Intersect ENT is a medical device company based in Menlo Park, California. It specializes in developing innovative therapies for Ear, Nose, and Throat surgeons to enhance patient care, focusing on treatments for chronic rhinosinusitis.

AtheroMed, Inc. is a medical device company based in Menlo Park, California, which specializes in developing catheter-based treatments for peripheral arterial disease (PAD). Founded in 2006, AtheroMed's innovative systems address a range of vessel sizes, from small arteries at the ankle to larger ones above the knee. The company aims to improve patient outcomes through its targeted therapies, facilitating more effective treatment options for individuals suffering from PAD.

HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.

Optichron, Inc. is a prominent company specializing in nonlinear signal processing technology, established in January 2003. The company designs and manufactures integrated circuits that address the challenges of nonlinear distortion, a critical barrier in signal processing across various industries. Recognized by industry experts as a major impediment to achieving optimal performance in communications and data conversion, nonlinear distortion has been historically managed by inefficient methods. Optichron has developed a proprietary mathematical approach that underpins its robust integrated circuit architecture, leading to innovative linearization products. These products efficiently eliminate all forms of nonlinear distortion, significantly enhancing system design parameters while reducing component count, overall costs, and power consumption. Optichron's technology is utilized in diverse applications, including wireless communications, software-defined radio, medical imaging, satellite communications, radar, infrared imaging, and test and measurement instrumentation, providing substantial improvements in system-level cost and performance.

Founded in 2003, Intersect ENT is a medical device company based in Menlo Park, California. It specializes in developing innovative therapies for Ear, Nose, and Throat surgeons to enhance patient care, focusing on treatments for chronic rhinosinusitis.

Neoconix, Inc. is a supplier of low-profile, high-performance electrical connectors catering to mobile, enterprise IT, and industrial markets. Founded in 2002 and based in San Jose, California, the company specializes in miniaturized connectors that leverage its patented PCBeam technology. This technology utilizes standard printed circuit lithographic processes, enabling rapid development and competitive pricing for custom electrical connector solutions. Neoconix offers a diverse range of products, including standard mobile and consumer connectors, high-speed connectors, and various custom connector options for applications in computing, telecommunications, consumer electronics, military-aerospace, medical devices, and test equipment. With over 60 patents issued or pending, Neoconix is recognized for delivering some of the industry's lowest profile connectors, achieving high reliability and extreme performance exceeding 25Gb/s. The company was previously known as Epic Technology, Inc. before adopting its current name in December 2004.

Sanarus Medical, Inc. specializes in developing and marketing minimally invasive devices for the diagnosis and treatment of breast tumors. The company offers the Visica Treatment System, which utilizes cryoablation to treat breast fibroadenomas, and the Cassi II rotational core biopsy system, an automated device designed for obtaining contiguous biopsy samples. Additionally, Sanarus provides the ImarC tissue marker system, which includes breast tissue markers visible under various imaging modalities. Founded in 1999 and headquartered in Pleasanton, California, Sanarus Medical focuses on providing innovative solutions for both cancerous and non-cancerous breast conditions.

Intuity Medical, Inc. is a medical technology company specializing in blood glucose monitoring systems for diabetes management. Founded in 2002 and headquartered in Fremont, California, the company is known for its innovative POGO Automatic Blood Glucose Monitoring System. This system is the first FDA-cleared automatic, one-step blood glucose meter that integrates lancing, blood collection, and analysis into a single cartridge capable of performing ten tests. Intuity Medical aims to provide a convenient and discreet solution for patients who require regular blood glucose testing, enhancing their ability to manage their diabetes effectively. The company was previously known as Rosedale Medical, Inc. until it rebranded in June 2007.

Neoconix, Inc. is a supplier of low-profile, high-performance electrical connectors catering to mobile, enterprise IT, and industrial markets. Founded in 2002 and based in San Jose, California, the company specializes in miniaturized connectors that leverage its patented PCBeam technology. This technology utilizes standard printed circuit lithographic processes, enabling rapid development and competitive pricing for custom electrical connector solutions. Neoconix offers a diverse range of products, including standard mobile and consumer connectors, high-speed connectors, and various custom connector options for applications in computing, telecommunications, consumer electronics, military-aerospace, medical devices, and test equipment. With over 60 patents issued or pending, Neoconix is recognized for delivering some of the industry's lowest profile connectors, achieving high reliability and extreme performance exceeding 25Gb/s. The company was previously known as Epic Technology, Inc. before adopting its current name in December 2004.

Neoconix, Inc. is a supplier of low-profile, high-performance electrical connectors catering to mobile, enterprise IT, and industrial markets. Founded in 2002 and based in San Jose, California, the company specializes in miniaturized connectors that leverage its patented PCBeam technology. This technology utilizes standard printed circuit lithographic processes, enabling rapid development and competitive pricing for custom electrical connector solutions. Neoconix offers a diverse range of products, including standard mobile and consumer connectors, high-speed connectors, and various custom connector options for applications in computing, telecommunications, consumer electronics, military-aerospace, medical devices, and test equipment. With over 60 patents issued or pending, Neoconix is recognized for delivering some of the industry's lowest profile connectors, achieving high reliability and extreme performance exceeding 25Gb/s. The company was previously known as Epic Technology, Inc. before adopting its current name in December 2004.

Sanarus Medical, Inc. specializes in developing and marketing minimally invasive devices for the diagnosis and treatment of breast tumors. The company offers the Visica Treatment System, which utilizes cryoablation to treat breast fibroadenomas, and the Cassi II rotational core biopsy system, an automated device designed for obtaining contiguous biopsy samples. Additionally, Sanarus provides the ImarC tissue marker system, which includes breast tissue markers visible under various imaging modalities. Founded in 1999 and headquartered in Pleasanton, California, Sanarus Medical focuses on providing innovative solutions for both cancerous and non-cancerous breast conditions.

Optichron, Inc. is a prominent company specializing in nonlinear signal processing technology, established in January 2003. The company designs and manufactures integrated circuits that address the challenges of nonlinear distortion, a critical barrier in signal processing across various industries. Recognized by industry experts as a major impediment to achieving optimal performance in communications and data conversion, nonlinear distortion has been historically managed by inefficient methods. Optichron has developed a proprietary mathematical approach that underpins its robust integrated circuit architecture, leading to innovative linearization products. These products efficiently eliminate all forms of nonlinear distortion, significantly enhancing system design parameters while reducing component count, overall costs, and power consumption. Optichron's technology is utilized in diverse applications, including wireless communications, software-defined radio, medical imaging, satellite communications, radar, infrared imaging, and test and measurement instrumentation, providing substantial improvements in system-level cost and performance.

Accumetrics is a privately-held company based in San Diego, California, that specializes in the development, manufacturing, and marketing of the VerifyNow System, a suite of assays designed to assess platelet function. Founded in 1996, Accumetrics initially sold to Radiometer in 2000, but was repurchased by its management and investors in 2003. The VerifyNow System allows for the measurement of individual responses to various antiplatelet agents, providing critical diagnostic instrumentation and test kits that support clinicians in personalizing antiplatelet therapy for improved patient outcomes.

Sanarus Medical, Inc. specializes in developing and marketing minimally invasive devices for the diagnosis and treatment of breast tumors. The company offers the Visica Treatment System, which utilizes cryoablation to treat breast fibroadenomas, and the Cassi II rotational core biopsy system, an automated device designed for obtaining contiguous biopsy samples. Additionally, Sanarus provides the ImarC tissue marker system, which includes breast tissue markers visible under various imaging modalities. Founded in 1999 and headquartered in Pleasanton, California, Sanarus Medical focuses on providing innovative solutions for both cancerous and non-cancerous breast conditions.

MicroVention Terumo is a medical device company headquartered in Tustin, California, specializing in catheter-based and minimally invasive neuroendovascular technologies aimed at treating cerebral aneurysms and other neurovascular diseases. Founded in 1997, it operates as a subsidiary of Terumo Corporation. The company develops a range of products, including delivery and detachment systems, access products, intraluminal devices, occlusion balloons, and flow diverters. Notably, MicroVention Terumo offers advanced embolization solutions such as the HydroCoil Embolic System, which utilizes platinum micro-coil technology, and the MicroPlex Coil System, which features a combination of framing, helical filling, and finishing coils to effectively address various types of aneurysm morphologies. Its products are distributed through a network of specialty distributors across North America, South America, Europe, Africa, the Middle East, and Asia Pacific, contributing to improved patient outcomes in the treatment of vascular conditions.

AtriCure specializes in developing, manufacturing, and distributing medical devices for cardiac surgery. Its primary products include systems for atrial fibrillation treatment, left atrial appendage management, and post-operative pain relief. AtriCure serves medical centers globally through direct sales and distributors.

Healinx is a unique medical relationship management application service provider (ASP). Our mission is to increase communication and the satisfaction level between patients and their doctors, while enhancing physician practice efficiency and profitability. By providing a Web-based channel that links patients directly to their personal doctors, Healinx allows patients to communicate with their doctors or access their medical information anytime -- from anywhere. In addition, patients can receive personalized health information from their doctors. The Healinx customized Internet messaging enables doctors and patients to communicate online with state of the art security and privacy. In addition, the Healinx channel includes a set of tools for electronic prescriptions and preventive care.

Sanarus Medical, Inc. specializes in developing and marketing minimally invasive devices for the diagnosis and treatment of breast tumors. The company offers the Visica Treatment System, which utilizes cryoablation to treat breast fibroadenomas, and the Cassi II rotational core biopsy system, an automated device designed for obtaining contiguous biopsy samples. Additionally, Sanarus provides the ImarC tissue marker system, which includes breast tissue markers visible under various imaging modalities. Founded in 1999 and headquartered in Pleasanton, California, Sanarus Medical focuses on providing innovative solutions for both cancerous and non-cancerous breast conditions.

AtriCure specializes in developing, manufacturing, and distributing medical devices for cardiac surgery. Its primary products include systems for atrial fibrillation treatment, left atrial appendage management, and post-operative pain relief. AtriCure serves medical centers globally through direct sales and distributors.

Healinx is a unique medical relationship management application service provider (ASP). Our mission is to increase communication and the satisfaction level between patients and their doctors, while enhancing physician practice efficiency and profitability. By providing a Web-based channel that links patients directly to their personal doctors, Healinx allows patients to communicate with their doctors or access their medical information anytime -- from anywhere. In addition, patients can receive personalized health information from their doctors. The Healinx customized Internet messaging enables doctors and patients to communicate online with state of the art security and privacy. In addition, the Healinx channel includes a set of tools for electronic prescriptions and preventive care.

St. Francis Medical Technologies is a privately held company that manufactures the X-Stop interspinous process decompression system. The X-Stop implant is the first FDA-approved interspinous process device indicated for treating lumbar spinal stenosis.

CardioThoracic Systems designs, develops, and manufactures surgical products and systems for minimally invasive cardiac surgery. The Company's current products are designed to enable the majority of cardiothoracic surgeons, using their existing skills coupled with company-sponsored training, to perform MICS on a beating heart. The OPCAB (Off Pump Coronary Artery Bypass) and MIDCAB (Minimally Invasive Direct Coronary Artery Bypass) procedures eliminate the need for a heart-lung machine, and recent studies indicate that the MICS procedures reduce the trauma, procedural costs and post-surgical complications associated with conventional coronary artery bypass graft (CABG) surgery while providing long-term procedural success rates comparable to CABG surgery. CardioThoracic Systems was founded in 1994 and is based in Cupertino, California. As of November 15, 1999, CardioThoracic Systems, Inc. was acquired by Guidant Corp.