U.S. Venture Partners

U.S. Venture Partners is a Menlo Park-based venture capital firm established in 1981 that concentrates on early-stage and growth investments in technology and healthcare. The firm backs business-to-business software, IT security, consumer internet, mobile, e-commerce, and IT-enabled healthcare services, as well as digital health, cloud technology, and life sciences including oncology. Its focus spans enterprise software, cybersecurity, healthcare IT, SaaS, manufacturing, and related sectors on the West Coast. The team comprises former entrepreneurs, technologists, executives, and industry experts who help portfolio companies scale and reach customers.

Dale Holladay

CFO

Past deals in Oregon

HeartFlow

Convertible Note in 2025
HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.

Sparrow Pharmaceuticals

Venture Round in 2024
Sparrow Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing treatments for disorders of corticosteroid excess. Founded in 2013 and based in Portland, Oregon, the company seeks to spare patients from the adverse effects of steroids by leveraging insights into corticosteroid biology. Its lead product, SPI-62, is an oral small molecule designed to target the source of active intracellular corticosteroids in key tissues, with a pipeline aimed at hypercortisolism and related autoimmune and inflammatory conditions caused by endogenous cortisol excess or long-term corticosteroid therapy.

HeartFlow

Series F in 2023
HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.

Sparrow Pharmaceuticals

Series A in 2021
Sparrow Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing treatments for disorders of corticosteroid excess. Founded in 2013 and based in Portland, Oregon, the company seeks to spare patients from the adverse effects of steroids by leveraging insights into corticosteroid biology. Its lead product, SPI-62, is an oral small molecule designed to target the source of active intracellular corticosteroids in key tissues, with a pipeline aimed at hypercortisolism and related autoimmune and inflammatory conditions caused by endogenous cortisol excess or long-term corticosteroid therapy.

Act-On Software

Venture Round in 2021
Act-On Software, Inc. is a developer of a cloud-based marketing automation platform tailored for small and mid-sized businesses. The platform enables marketers to create and manage various marketing campaigns, including email marketing, website lead generation, social media marketing, and account-based marketing. Act-On's solutions help organizations attract prospects, convert leads, and measure campaign effectiveness while enhancing customer engagement and brand awareness. Additionally, the company offers professional consulting, support, and training services to optimize the use of its platform. Act-On serves diverse industries such as banking, insurance, manufacturing, technology, and agencies. Founded in 2006 and headquartered in Portland, Oregon, Act-On also has locations in Scottsdale, Arizona, and Reading, United Kingdom.

Act-On Software

Venture Round in 2014
Act-On Software, Inc. is a developer of a cloud-based marketing automation platform tailored for small and mid-sized businesses. The platform enables marketers to create and manage various marketing campaigns, including email marketing, website lead generation, social media marketing, and account-based marketing. Act-On's solutions help organizations attract prospects, convert leads, and measure campaign effectiveness while enhancing customer engagement and brand awareness. Additionally, the company offers professional consulting, support, and training services to optimize the use of its platform. Act-On serves diverse industries such as banking, insurance, manufacturing, technology, and agencies. Founded in 2006 and headquartered in Portland, Oregon, Act-On also has locations in Scottsdale, Arizona, and Reading, United Kingdom.

Act-On Software

Series D in 2012
Act-On Software, Inc. is a developer of a cloud-based marketing automation platform tailored for small and mid-sized businesses. The platform enables marketers to create and manage various marketing campaigns, including email marketing, website lead generation, social media marketing, and account-based marketing. Act-On's solutions help organizations attract prospects, convert leads, and measure campaign effectiveness while enhancing customer engagement and brand awareness. Additionally, the company offers professional consulting, support, and training services to optimize the use of its platform. Act-On serves diverse industries such as banking, insurance, manufacturing, technology, and agencies. Founded in 2006 and headquartered in Portland, Oregon, Act-On also has locations in Scottsdale, Arizona, and Reading, United Kingdom.

Act-On Software

Series C in 2011
Act-On Software, Inc. is a developer of a cloud-based marketing automation platform tailored for small and mid-sized businesses. The platform enables marketers to create and manage various marketing campaigns, including email marketing, website lead generation, social media marketing, and account-based marketing. Act-On's solutions help organizations attract prospects, convert leads, and measure campaign effectiveness while enhancing customer engagement and brand awareness. Additionally, the company offers professional consulting, support, and training services to optimize the use of its platform. Act-On serves diverse industries such as banking, insurance, manufacturing, technology, and agencies. Founded in 2006 and headquartered in Portland, Oregon, Act-On also has locations in Scottsdale, Arizona, and Reading, United Kingdom.

Act-On Software

Series B in 2010
Act-On Software, Inc. is a developer of a cloud-based marketing automation platform tailored for small and mid-sized businesses. The platform enables marketers to create and manage various marketing campaigns, including email marketing, website lead generation, social media marketing, and account-based marketing. Act-On's solutions help organizations attract prospects, convert leads, and measure campaign effectiveness while enhancing customer engagement and brand awareness. Additionally, the company offers professional consulting, support, and training services to optimize the use of its platform. Act-On serves diverse industries such as banking, insurance, manufacturing, technology, and agencies. Founded in 2006 and headquartered in Portland, Oregon, Act-On also has locations in Scottsdale, Arizona, and Reading, United Kingdom.

Act-On Software

Venture Round in 2010
Act-On Software, Inc. is a developer of a cloud-based marketing automation platform tailored for small and mid-sized businesses. The platform enables marketers to create and manage various marketing campaigns, including email marketing, website lead generation, social media marketing, and account-based marketing. Act-On's solutions help organizations attract prospects, convert leads, and measure campaign effectiveness while enhancing customer engagement and brand awareness. Additionally, the company offers professional consulting, support, and training services to optimize the use of its platform. Act-On serves diverse industries such as banking, insurance, manufacturing, technology, and agencies. Founded in 2006 and headquartered in Portland, Oregon, Act-On also has locations in Scottsdale, Arizona, and Reading, United Kingdom.

HeartFlow

Seed Round in 2008
HeartFlow specializes in precision heart care, offering a non-invasive solution for diagnosing coronary artery disease. Its proprietary HeartFlow FFRCT Analysis uses artificial intelligence to create a personalized 3D model of the heart, enabling clinicians to evaluate blood flow and determine optimal treatment. Commercially available in the United States, UK, Canada, Europe, and Japan.
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