Two Sigma Ventures

Tive is a Boston-based startup that helps companies take the surprises out of their supply chains through true end-to-end visibility. It is the easiest way for companies to manage their supply chain – and get results. Unlock unparalleled insight and enhanced visibility. They help companies improve efficiency and meet regulatory requirements by providing an end-to-end sensor solution to visualize, optimize, and monitor operations in real-time.

Gameto is a biotechnology company focused on improving female reproductive health through innovative therapies. Recognizing that women's health is an underserved area with limited treatment options, Gameto aims to develop advanced solutions that enhance patient outcomes. The company utilizes cellular engineering to create female reproductive cell lines, employing proprietary combinations of transcription factors to reprogram human induced pluripotent stem cells (hiPSCs) into engineered ovarian and endometrial cell lines that function similarly to natural cells. This platform supports a portfolio of cellular therapeutics targeting various female reproductive diseases. Gameto's flagship program, Fertilo, is designed to enhance the processes of in vitro fertilization (IVF) and egg freezing, making them shorter, safer, and more effective. Additional applications of Gameto's technology include Deovo, an organoid of the female reproductive system, and Ameno, a cell-based therapeutic aimed at alleviating the health issues associated with primary ovarian insufficiency and menopause.

Xaira Therapeutics is an integrated biotechnology company focused on revolutionizing drug discovery and development through the application of artificial intelligence. Headquartered in the San Francisco Bay Area, Xaira combines expertise in machine learning, extensive biological and clinical data generation, and robust therapeutic product development. By harnessing advanced AI techniques, the company aims to enhance the understanding of biological processes and improve the effectiveness of therapies. Xaira's approach encompasses all stages of drug discovery, striving to transform how diseases are treated and enabling clients to deliver innovative therapeutic solutions.

Nullify is a cybersecurity platform that develops AI agents designed to autonomously handle application security tasks, mimicking the reasoning and decision-making capabilities of human security engineers. This innovation addresses the significant disparity between the number of software engineers and security engineers, which stands at 100 to 1, exacerbated by a growing shortage of cybersecurity professionals. By automating key aspects of product security work, such as testing, prioritization, remediation, and threat modeling, Nullify allows organizations to enhance their software security efficiently without the need to expand their security teams. The platform serves as a comprehensive solution that integrates various open-source security testing tools, executing them on entire codebases with a single command and producing a coherent output. This enables developers to create more secure software while allowing security teams to concentrate on more strategic security initiatives.

Treet launched their own completely branded peer-to-peer resale platform to assist fashion firms in becoming more circular and in controlling the secondary market for the products they make. In order to buy and sell used goods from one another, customers of Treet Marketplaces use a secondary website that accepts payments in the form of cash or brand credit. While brands split the profits, Treet takes care of all the logistics and support. Treet was established in 2021 by Jake Disraeli and Sonia Yang in San Francisco, California.

Ansel Health is a developer of a health insurance platform designed for employers to improve employee benefits through a straightforward supplemental health benefits plan. The company provides insurance services that offer cash payouts to individuals diagnosed with various conditions, including those related to COVID-19. This support helps alleviate financial burdens associated with serious health issues, ensuring that employees have access to necessary resources for recovery.

Anomalo is a developer of an artificial intelligence-based data validation tool that helps organizations continuously inspect and validate the data entering their warehouses. The company’s solution automatically detects and explains issues in enterprise data, facilitating a seamless connection to data warehouses. By employing automated machine learning technology, Anomalo enables companies to validate and document their data with minimal configuration, eliminating the need for users to write any code. This approach streamlines the data validation process, enhancing data integrity and reliability for enterprises.

Developer of artificial intelligence-driven solar cell technology platform designed to build next-generation cells. The company's platform technology offers perovskite silicon tandem solar cells that are optimized and improved based on data from those that came before and provides mainstream silicon technology that has a combination of materials and processes to reach its fundamental limits, enabling clients with new solar and semiconductor technologies in a fraction of the time and cost, compared to conventional methods.

Membrane Labs is a fintech firm that provides institutional digital asset services for OTC transactions.

Cerby, Inc., founded in 2020 and based in Alameda, California, specializes in cybersecurity tools that address the challenges of managing disconnected applications. The company offers a comprehensive access management platform that automates security tasks by leveraging identity providers, thereby eliminating the need for manual tools and compensating controls like enterprise password managers. Cerby's patent-pending access orchestration engine facilitates passwordless authentication for applications that do not support standard protocols such as SSO, SAML, or SCIM. By automating processes such as offboarding and two-factor authentication enrollment, Cerby enhances visibility and control for identity and access management professionals, ultimately reducing risks and costs while increasing organizational productivity.

Raincoat specializes in creating scalable embedded climate insurance products, supported by an automated infrastructure. The company collaborates with insurers, governments, and financial institutions to develop parametric insurance solutions that provide immediate payouts for catastrophe policies. By unlocking new markets, Raincoat enables businesses to achieve financial resilience against the impact of natural disasters, thus promoting climate resilience on a larger scale.

Building the hyperverse. We let people stream, make content, and make friends as an avatar.

Omni Network is a blockchain that supports applications in functioning across all rollups. The company creates technologies that support personal freedoms and enable global collaboration.

NetBox Labs makes the management of complex networks easier for operators by delivering open and composable products. The company's product NetBox Cloud offers an enterprise-grade, SaaS version of open-source NetBox.

Crossover Markets Group operates a digital asset exchange specifically tailored to address the liquidity requirements of institutional clients. The company's platform is engineered to enhance the speed of cryptocurrency trading and minimize latency, aligning with the performance standards demanded by institutional investors in traditional foreign exchange and equity markets. By facilitating seamless cryptocurrency transactions, Crossover Markets aims to provide a reliable trading environment that supports the unique needs of its institutional clientele.

C3 Exchange operates a self-custodial trading platform that facilitates the buying and selling of spot and derivative assets. The exchange combines the advantages of self-custody and decentralization with the performance and accessibility typically associated with traditional trading platforms. Its innovative clearing engine protocol allows for cross-margin and cross-collateralization, enabling traders to optimize their capital usage by calculating margin requirements across all open positions in their accounts. Through this approach, C3 Exchange aims to enhance the trading experience while maintaining user control over their assets.

Freeform is a 3D printing company that specializes in metal 3D printing solutions for manufacturing industries. The company focuses on deploying software-defined, self-sufficient metal 3D printing factories globally, effectively merging software scalability with physical production capabilities. Freeform's proprietary technology utilizes advanced sensing, real-time controls, and data-driven learning, enabling the production of digitally verified and flawless parts at unprecedented speeds and costs. This innovative approach allows manufacturers across various sectors to transition swiftly from concept to volume production, making the advantages of 3D printing accessible to a broader range of industries.

Osmo gives computers a sense of smell that improves the health and well-being of human life. Osmo brings together frontier AI and olfactory science to tackle a historic challenge. While they are initially focused on the intricate world of fragrance, their ultimate objective is to enhance the health and well-being of human life through the sense of smell.

Rive is transforming the way designers and developers collaborate by allowing them to create animated interactive experiences that run faster, store smaller, and use less memory than existing design solutions. This new workflow allows designers and developers to concentrate on what they do best, eliminating the need for a complex handoff. Graphics such as animated UI, characters, heads-up displays, hero moments, buttons, icons, and emojis can be iterated on freely by creative teams. Rive saves businesses time and engineering resources by enabling designers to create interactive content from concept to production.

Enveda Biosciences is a biotechnology company focused on drug discovery through the exploration of chemical diversity found in nature. Utilizing AI-powered tools, the company develops a robust database of chemical molecules derived from living organisms. Enveda's platform integrates machine learning, metabolomics, and robotics to analyze natural samples for their chemical structures and biological activities. This innovative approach allows for the efficient identification of potential new medicines, including antibiotics and hypotensives, without the need for isolating individual compounds or conducting extensive experiments. By harnessing nature's hidden chemistry, Enveda aims to accelerate the development of novel therapeutics for the healthcare industry.

Cajal Neuroscience is a biotechnology company focused on developing innovative therapies for neurodegenerative diseases. By integrating human genetics, functional genomics, and advanced microscopy, the company aims to identify novel therapeutic targets. Cajal utilizes a range of cutting-edge technologies, including high-throughput functional genomics and multi-omics approaches, to screen for targets that significantly influence the progression of neurodegenerative diseases. This comprehensive methodology supports the development of precision medicine, ultimately aiding healthcare professionals in treating patients affected by these conditions.

Hexagon Bio, Inc. is a biotechnology company based in Menlo Park, California, focused on discovering novel drugs for diseases that lack effective treatments. Established in 2016, the company utilizes a data-driven approach that combines genomics, synthetic biology, and computational techniques. By mining genomic data from fungal genomes, Hexagon Bio aims to identify targeted small molecule therapeutics. Its proprietary platform leverages data science to engineer drugs from DNA sequences, enabling the identification of small molecule inhibitors that interact with specific target proteins. This innovative method allows researchers to tap into the global metagenome, facilitating the development of new medicines aimed at improving patient outcomes.

Flatfile Inc. is a company that specializes in data onboarding solutions, enabling developers to efficiently validate, map, and import CSV data from various web applications. Founded in 2018 and based in Denver, Colorado, Flatfile offers a platform that integrates seamlessly with software applications, allowing users to upload data through formats such as CSV, XLS, or TSV. Its key products include Portal, which provides an import button embedded via a JavaScript snippet, and Concierge, which creates secure collaborative workspaces for organizations to manage complex data ingestion challenges. The platform is designed to enhance developer productivity, reduce costs, and improve data quality by learning to identify and clean incoming data over time. Numerous companies, including AstraZeneca and Square, utilize Flatfile’s API-first platform to streamline their data import processes.

Xilis, Inc. is a biotechnology company based in Chapel Hill, North Carolina, founded in 2019. It specializes in developing advanced organoid technologies aimed at guiding precision therapy for cancer patients and enhancing drug discovery processes. The company's flagship platform, XilisµO, facilitates rapid diagnostics and personalized drug screening while providing scalable, patient-derived models for high-throughput drug discovery. This technology supports physicians and pharmaceutical companies in creating tailored treatments by enabling effective drug screening, ultimately contributing to more precise and cost-efficient cancer therapies.

Isabl is a startup focused on developing advanced diagnostic assays for cancer through whole-genome and RNA sequencing. Founded in 2020 after incubating its technology at Memorial Sloan Kettering Cancer Center from 2015 to 2019, Isabl participated in the Winter 2020 batch of Y Combinator and has raised $3 million in seed funding from investors including Two Sigma Ventures and BoxOne Ventures. In 2021, the company received the FDA Breakthrough Device designation, highlighting the innovative nature of its cancer diagnostic tests. Additionally, Isabl was awarded a $2 million direct-to-phase-2 SBIR grant from the National Cancer Institute to further the development of its specialized test, Isabl GxT, aimed at pediatric and rare solid tumors. The leadership team, comprising Dr. Elli Papaemmanuil, Dr. Andrew Kung, and Juan Medina, brings extensive expertise in precision medicine, computational biology, and software engineering, with a proven history in biomarker discovery and clinical decision support. Isabl's platform enhances the ability of oncology centers to analyze genomic data effectively and supports the creation of data-driven automation in cancer diagnosis.

Tive is a Boston-based startup that helps companies take the surprises out of their supply chains through true end-to-end visibility. It is the easiest way for companies to manage their supply chain – and get results. Unlock unparalleled insight and enhanced visibility. They help companies improve efficiency and meet regulatory requirements by providing an end-to-end sensor solution to visualize, optimize, and monitor operations in real-time.

Remote offers payroll, tax, HR, and compliance solutions tailored for distributed teams. The company has developed a recruiting platform that assists organizations of all sizes in hiring top talent globally. This platform enables human resource executives to recruit individuals without the risk of compliance issues. Additionally, it supports management in project allocation and payment processes, ultimately enhancing productivity and expanding the workforce within client organizations.

Okteto Inc. is a software company that operates a cloud application development platform specifically designed for Kubernetes. Founded in 2018 and headquartered in San Francisco, California, Okteto provides a suite of tools that enable developers to easily access and manage Kubernetes infrastructure. Its offerings include Okteto Enterprise, which allows users to visualize workloads through a developer-friendly dashboard, apply security policies, and create secure namespaces. The platform facilitates the rapid deployment of applications, supports integration with the Okteto CLI, and ensures that sensitive credentials are securely managed. By allowing developers to instantly set up pre-configured environments in the cloud, Okteto aims to enhance the speed and efficiency of cloud-native application development.

Timescale is a modern cloud platform built on PostgreSQL, specializing in time-series data, events, and analytics. It provides an open-source SQL database designed to handle large-scale data and complex queries, making it particularly suited for applications involving the Internet of Things (IoT). By integrating directly into the query planner and execution engine, Timescale enhances performance through advanced distributed query optimizations. This enables users to effectively organize, store, analyze, and derive insights from time-series and machine data. With a global workforce and strong backing from prominent investors, Timescale aims to empower software developers and businesses around the world to innovate in computing.

Kallyope Inc. is a biotechnology company based in New York City that focuses on the gut-brain axis to develop innovative therapeutics and consumer products aimed at enhancing human health. Founded in 2014, Kallyope employs a multidisciplinary approach, integrating technologies such as sequencing, computational biology, neural imaging, and human genetics to deepen the understanding of gut-brain biology. This comprehensive understanding enables the company to create effective and well-tolerated oral medications targeting various health issues, including diabetes, obesity, gut disorders, inflammatory diseases, migraines, and allergies. With a team of experienced scientists and a strong foundation in drug discovery, Kallyope aims to address significant unmet medical needs through its research and development efforts.

Terray Therapeutics is a biotechnology company based in Pasadena, California, founded in 2018. The company specializes in developing innovative treatments for complex human diseases by integrating experimentation and computation to enhance small molecule drug discovery. Terray's unique platform employs ultra-dense microarray technology alongside artificial intelligence and synthetic chemistry to generate extensive and precise chemical datasets. This allows for a rapid design-make-test-analyze cycle, facilitating efficient exploration of chemical space and mapping biochemical interactions between small molecules and disease causes. By utilizing automation and machine learning, Terray addresses significant therapeutic challenges, ultimately guiding the next cycles of drug design and experimentation.

Radar provides a location data infrastructure platform designed for app developers to integrate location-based services into their applications. The platform facilitates the creation of personalized and contextually aware experiences through features such as geofencing, place detection, and location tracking. It supports a variety of use cases across sectors like retail, travel, and logistics, and offers tools for easy integration, including mobile SDKs and APIs. Radar's capabilities include detecting home, work, and traveling locations, as well as geocoding addresses into geographic coordinates. The company emphasizes privacy and security, ensuring responsible handling of location data. Founded in 2016, Radar continues to innovate with new APIs in private beta that enhance the functionality of its platform.

Rift Finance is a decentralized protocol that supercharges DAO growth through restructured incentive frameworks. Rift allows DAOs to deploy governance tokens from their treasuries to deepen token liquidity without having to give up ownership.

Exai Bio is a next-generation liquid biopsy company. Exai bio proprietary RNA and artificial intelligence-based liquid biopsy platform deliver clinical insights into cancer biology to enable the earliest, most accurate diagnosis of cancer.

NewtonX, Inc. is a B2B research company based in New York, founded in 2016. It operates an online marketplace that connects professional services firms and financial institutions to verified senior professionals across various industries. Utilizing an advanced AI-driven algorithm known as the NewtonX Graph, the company custom recruits audiences tailored to specific business inquiries from a network of over 1.1 billion professionals. NewtonX provides decision-quality data through large-scale quantitative surveys, qualitative interviews, long-term consultations, and personalized research plans. Its platform, NewtonX Prime, offers clients instant access to expert surveys and transcripts, empowering businesses to make informed decisions. The company collaborates with Fortune 500 companies, top consultancies, and investors to enhance the standard of B2B insights.

Comet ML Inc. is a New York-based company that provides a meta machine learning platform designed to assist data science teams and individuals in building reliable machine learning models for real-world applications. The platform enables users to automatically track datasets, code changes, experimentation history, and production models, thereby enhancing efficiency, transparency, and reproducibility in the machine learning process. By allowing data scientists to maintain their preferred workflows while effectively collaborating and tracking previous work, Comet facilitates a more organized approach to experimentation. Additionally, the platform incorporates bayesian hyperparameter optimization, which streamlines the model tuning process and reduces the time typically required for manual adjustments. This comprehensive solution increases visibility into data science efforts and improves the overall effectiveness of machine learning initiatives within organizations.

Facet is a computer software company that provides artists and engineers, aiming to redefine and humanize the creative process.

Socure Inc. specializes in digital identity verification solutions, utilizing artificial intelligence and machine learning to authenticate identities in real-time. Its flagship platform, Socure ID+, integrates data from various online and offline sources, including email, phone numbers, and social media, to streamline customer identification processes and ensure compliance with regulations such as know your customer (KYC) and anti-money laundering (AML). In addition to Socure ID+, the company offers tools like Aida, an AI-driven bot for real-time identity validation; Docv, a document verification solution; and Sigma Synthetic Fraud, which targets synthetic identity fraud. Serving a diverse clientele that includes software and financial firms, as well as integration partners and sponsor banks, Socure aims to eliminate identity fraud and enhance security for online transactions. Founded in 2012 and headquartered in New York, Socure has established strategic partnerships to expand its reach and effectiveness in the identity verification landscape.

RightRev provides an automated revenue recognition solution that helps businesses manage financial reporting in compliance with current accounting standards. The platform integrates seamlessly with sales operations and revenue accounting processes, facilitating accurate tracking of revenue across various models, including subscriptions, one-time sales, and services. By enhancing existing customer relationship management and configure, price, quote tools, RightRev's solution offers a comprehensive approach to revenue reporting, ensuring transparency and reducing the risk of financial misstatements. The platform is designed to support finance professionals in navigating complex revenue accounting requirements, such as those outlined in ASC 606 and IFRS 15.

Anomalo is a developer of an artificial intelligence-based data validation tool that helps organizations continuously inspect and validate the data entering their warehouses. The company’s solution automatically detects and explains issues in enterprise data, facilitating a seamless connection to data warehouses. By employing automated machine learning technology, Anomalo enables companies to validate and document their data with minimal configuration, eliminating the need for users to write any code. This approach streamlines the data validation process, enhancing data integrity and reliability for enterprises.

Nelo is a financial technology company based in Mexico City, established on April 8, 2019. It specializes in developing a mobile application and a digital payment management platform that enables users to conduct financial transactions effectively. The platform allows individuals to send and request money easily, while also providing a free virtual card with no charges for account opening. This service facilitates real-time payment and balance tracking, empowering users to manage their funds in an affordable and secure manner.

Sora is a low-code intelligent workflow automation and data integration tool that connects different corporate applications such as HR, IT, and other systems and data sets to provide a smarter, more user-friendly experience for employees, business owners, and HR professionals.

Replicated, Inc. is a company that specializes in providing tools for the distribution and management of third-party applications within enterprise environments. Founded in 2014 and based in Culver City, California, Replicated addresses the needs of organizations seeking to deploy Software as a Service (SaaS) applications securely within their own firewalls. Its platform enables software vendors to deliver cloud-native applications that can be installed and managed in private data centers or private cloud environments. This approach enhances security and control for clients while simplifying customer support processes associated with on-premises software solutions.

Hexagon Bio, Inc. is a biotechnology company based in Menlo Park, California, focused on discovering novel drugs for diseases that lack effective treatments. Established in 2016, the company utilizes a data-driven approach that combines genomics, synthetic biology, and computational techniques. By mining genomic data from fungal genomes, Hexagon Bio aims to identify targeted small molecule therapeutics. Its proprietary platform leverages data science to engineer drugs from DNA sequences, enabling the identification of small molecule inhibitors that interact with specific target proteins. This innovative method allows researchers to tap into the global metagenome, facilitating the development of new medicines aimed at improving patient outcomes.

Castor is an international health-tech company founded by CEO Derk Arts, MD, Ph.D. Their cloud-based clinical data platform simplifies the entire clinical trial process, from recruitment to analysis, for researchers worldwide. More than 50,000 researchers across 90 countries are using Castor to supercharge their research. Castor’s platform has supported more than 4,000 commercial and academic studies that cover a broad range of therapeutic areas including diabetes, cardiovascular disease, rare diseases, infectious diseases, and oncology. Researchers on the platform generate vast amounts of data from traditional and remote trials, and Castor recently reached milestones of 180,000,000 data points and 2,000,000 enrolled patients. Castor’s goal is to make the world’s research data reusable, enabling AI-driven clinical trials, and ultimately creating a future in which they maximize the impact of data through reuse.

Xilis, Inc. is a biotechnology company based in Chapel Hill, North Carolina, founded in 2019. It specializes in developing advanced organoid technologies aimed at guiding precision therapy for cancer patients and enhancing drug discovery processes. The company's flagship platform, XilisµO, facilitates rapid diagnostics and personalized drug screening while providing scalable, patient-derived models for high-throughput drug discovery. This technology supports physicians and pharmaceutical companies in creating tailored treatments by enabling effective drug screening, ultimately contributing to more precise and cost-efficient cancer therapies.

Enveda Biosciences is a biotechnology company focused on drug discovery through the exploration of chemical diversity found in nature. Utilizing AI-powered tools, the company develops a robust database of chemical molecules derived from living organisms. Enveda's platform integrates machine learning, metabolomics, and robotics to analyze natural samples for their chemical structures and biological activities. This innovative approach allows for the efficient identification of potential new medicines, including antibiotics and hypotensives, without the need for isolating individual compounds or conducting extensive experiments. By harnessing nature's hidden chemistry, Enveda aims to accelerate the development of novel therapeutics for the healthcare industry.

Formlogic is a provider of autonomous manufacturing technology focused on delivering precision components for the space and frontier industries. The company aims to revolutionize part production by addressing issues within the domestic supply chain. Its advanced technology enhances the capabilities of workers, allowing novices to achieve expert-level tolerances while increasing productivity for experienced operators. Formlogic offers rapid turnaround times, with production orders completed in weeks, and provides real-time order status updates. This approach enables industries to obtain custom machined components with close tolerances at scale, improving overall efficiency and customer experience.

Appia Bio is a biotechnology company dedicated to the research and development of allogeneic cell therapies that can be readily available for patients. The company focuses on creating engineered cell therapies for various medical conditions using its innovative ACUA technology platform. This platform utilizes the biology of lymphocyte development along with chimeric antigen receptor (CAR) and T-cell receptor (TCR) gene engineering to produce CAR-engineered invariant natural killer T (CAR-iNKT) cell subtypes derived from hematopoietic stem cells. By maturing and scaling healthy stem cells into these therapies, Appia Bio aims to provide safe and targeted cancer treatments, thereby enhancing accessibility to off-the-shelf cell therapies for physicians and patients alike.

Timescale is a modern cloud platform built on PostgreSQL, specializing in time-series data, events, and analytics. It provides an open-source SQL database designed to handle large-scale data and complex queries, making it particularly suited for applications involving the Internet of Things (IoT). By integrating directly into the query planner and execution engine, Timescale enhances performance through advanced distributed query optimizations. This enables users to effectively organize, store, analyze, and derive insights from time-series and machine data. With a global workforce and strong backing from prominent investors, Timescale aims to empower software developers and businesses around the world to innovate in computing.

Text Blaze is a productivity-focused platform that enables users to save and insert programmable text snippets across the web using keyboard shortcuts. This innovative tool not only allows for plain text snippets but also supports dynamic inputs from users and integrates seamlessly with other applications through no-code solutions. By offering customizable templates and collaboration features, Text Blaze aims to streamline workflows, reduce repetitive typing, and minimize errors. Its functionality fosters teamwork by allowing users to share snippets with colleagues, ultimately enhancing efficiency and maximizing productivity in various professional environments.

Wealthsimple Financial Inc. provides digital investment advisory services across Canada and operates additional offices in Brooklyn, New York, and London, United Kingdom. Founded in 2014 and headquartered in Toronto, the company offers a range of financial tools designed to help individuals grow and manage their wealth. Wealthsimple builds diversified portfolios of exchange-traded funds (ETFs) on behalf of its clients, enabling them to achieve their financial goals without the high fees and account minimums typical of traditional investment management. Additionally, Wealthsimple features on-demand financial planning solutions and a hybrid savings and spending product known as Wealthsimple Cash. The company focuses on making financial advice accessible and affordable, supported by a team of experienced financial professionals. As of September 2020, Wealthsimple operates as a subsidiary of Purpose Advisor Solutions Inc.

Boundless is a company based in Seattle, Washington, that aims to simplify the immigration process for individuals, families, and businesses. Founded in 2017, it offers a corporate immigration platform designed to empower users to navigate the complexities of immigration confidently and affordably. The platform provides essential tools, information, and personalized support, enabling clients to access legal expertise and file their applications online. By combining innovative software with expert legal guidance, Boundless is committed to making immigration more accessible and streamlined for everyone involved.

Per Diem offers a mobile application designed to assist local businesses in selling subscriptions online, akin to a personalized version of Amazon Prime. The platform equips restaurants with essential marketing and fulfillment tools, enabling them to establish a strong digital presence. Through the app, customers can place orders directly, track rewards, and receive notifications, which encourages more frequent patronage. This approach not only enhances customer engagement but also allows restaurants to generate recurring revenues through monthly and annual subscription models.

Facet is a computer software company that provides artists and engineers, aiming to redefine and humanize the creative process.

Comet ML Inc. is a New York-based company that provides a meta machine learning platform designed to assist data science teams and individuals in building reliable machine learning models for real-world applications. The platform enables users to automatically track datasets, code changes, experimentation history, and production models, thereby enhancing efficiency, transparency, and reproducibility in the machine learning process. By allowing data scientists to maintain their preferred workflows while effectively collaborating and tracking previous work, Comet facilitates a more organized approach to experimentation. Additionally, the platform incorporates bayesian hyperparameter optimization, which streamlines the model tuning process and reduces the time typically required for manual adjustments. This comprehensive solution increases visibility into data science efforts and improves the overall effectiveness of machine learning initiatives within organizations.

Tive is a Boston-based startup that helps companies take the surprises out of their supply chains through true end-to-end visibility. It is the easiest way for companies to manage their supply chain – and get results. Unlock unparalleled insight and enhanced visibility. They help companies improve efficiency and meet regulatory requirements by providing an end-to-end sensor solution to visualize, optimize, and monitor operations in real-time.

Cylera, Inc. is a cybersecurity company focused on protecting healthcare organizations from cyber threats and malware. Founded in 2017 and headquartered in New York, Cylera offers a comprehensive platform that utilizes patented technology to provide unified cybersecurity solutions. Their software specializes in asset management, risk analysis, and threat detection, specifically designed for the healthcare Internet of Things (IoT) environment. By identifying all connected devices, analyzing vulnerabilities, and mitigating threats in real time, Cylera enables healthcare providers and other organizations to effectively manage risks and respond automatically to potential security incidents.

Socure Inc. specializes in digital identity verification solutions, utilizing artificial intelligence and machine learning to authenticate identities in real-time. Its flagship platform, Socure ID+, integrates data from various online and offline sources, including email, phone numbers, and social media, to streamline customer identification processes and ensure compliance with regulations such as know your customer (KYC) and anti-money laundering (AML). In addition to Socure ID+, the company offers tools like Aida, an AI-driven bot for real-time identity validation; Docv, a document verification solution; and Sigma Synthetic Fraud, which targets synthetic identity fraud. Serving a diverse clientele that includes software and financial firms, as well as integration partners and sponsor banks, Socure aims to eliminate identity fraud and enhance security for online transactions. Founded in 2012 and headquartered in New York, Socure has established strategic partnerships to expand its reach and effectiveness in the identity verification landscape.

Insitro, Inc. is a data-driven company focused on drug discovery and development, particularly targeting nonalcoholic steatohepatitis (NASH). Founded in 2018 by Daphne Koller and based in South San Francisco, California, Insitro harnesses machine learning and high-throughput biology to revolutionize the process of drug discovery. The company creates extensive functional genomic data sets and integrates them with patient data through innovative machine learning techniques. This approach allows Insitro to build predictive models that enhance target selection, streamline the design of therapeutics, and optimize drug development strategies. By addressing critical challenges in pharmaceutical research and development, Insitro aims to accelerate the delivery of new and effective treatments to patients.

Flatfile Inc. is a company that specializes in data onboarding solutions, enabling developers to efficiently validate, map, and import CSV data from various web applications. Founded in 2018 and based in Denver, Colorado, Flatfile offers a platform that integrates seamlessly with software applications, allowing users to upload data through formats such as CSV, XLS, or TSV. Its key products include Portal, which provides an import button embedded via a JavaScript snippet, and Concierge, which creates secure collaborative workspaces for organizations to manage complex data ingestion challenges. The platform is designed to enhance developer productivity, reduce costs, and improve data quality by learning to identify and clean incoming data over time. Numerous companies, including AstraZeneca and Square, utilize Flatfile’s API-first platform to streamline their data import processes.

UMA is a decentralized platform focused on financial contracts, aiming to provide global market access through innovative technology. It allows users to trade derivative products without reliance on a centralized authority, minimizing risk and eliminating single points of failure. By enabling customers to create customized financial products, UMA facilitates automatic enforcement and immediate settlement of agreements. The platform also features a unique oracle that records verifiable truths or data on a blockchain, enhancing the integrity of the financial contracts. This structure incentivizes participants to challenge and provide evidence against recorded claims, fostering a transparent and robust ecosystem for decentralized finance.

Smartfrog Group, also known as Smartfrog & Canary Holding Inc., is a pioneer in consumer Internet of Things (IoT) software as a service (SaaS), serving users in over 180 countries. Established in 2015, Smartfrog introduced the first fully consumer-focused IoT SaaS product, providing an affordable and user-friendly DIY smart home security subscription service. In 2018, the company expanded into the U.S. market and merged with Canary Connect, establishing its headquarters in New York City. Smartfrog's end-to-end platform, protected by over 100 patents, enables data-driven business solutions across various product categories. Initially focused on smart home security, the company is expanding into new areas, including smart locks, in-home delivery, and care solutions for children, pets, and the elderly. The organization pursues growth through both organic development and strategic mergers and acquisitions.

Tive is a Boston-based startup that helps companies take the surprises out of their supply chains through true end-to-end visibility. It is the easiest way for companies to manage their supply chain – and get results. Unlock unparalleled insight and enhanced visibility. They help companies improve efficiency and meet regulatory requirements by providing an end-to-end sensor solution to visualize, optimize, and monitor operations in real-time.

Candu is a product experience platform designed for software teams aiming to enhance their applications' user interfaces. Founded in 2018 by Jonathan Anderson and Michele Riccardo Esposito, Candu allows teams to create personalized and effective onboarding experiences through its drag-and-drop editor, which requires no coding. The platform offers a comprehensive UI component library for building tailored experiences and includes an analytics suite that provides insights into user engagement and feature adoption. This enables businesses to continually refine their applications based on user behavior and feedback. Additionally, Candu supports the integration of in-product courses and training, allowing non-technical teams to embed learning experiences and measure their impact effectively.

Remote offers payroll, tax, HR, and compliance solutions tailored for distributed teams. The company has developed a recruiting platform that assists organizations of all sizes in hiring top talent globally. This platform enables human resource executives to recruit individuals without the risk of compliance issues. Additionally, it supports management in project allocation and payment processes, ultimately enhancing productivity and expanding the workforce within client organizations.

Replicated, Inc. is a company that specializes in providing tools for the distribution and management of third-party applications within enterprise environments. Founded in 2014 and based in Culver City, California, Replicated addresses the needs of organizations seeking to deploy Software as a Service (SaaS) applications securely within their own firewalls. Its platform enables software vendors to deliver cloud-native applications that can be installed and managed in private data centers or private cloud environments. This approach enhances security and control for clients while simplifying customer support processes associated with on-premises software solutions.

Wealthsimple Financial Inc. provides digital investment advisory services across Canada and operates additional offices in Brooklyn, New York, and London, United Kingdom. Founded in 2014 and headquartered in Toronto, the company offers a range of financial tools designed to help individuals grow and manage their wealth. Wealthsimple builds diversified portfolios of exchange-traded funds (ETFs) on behalf of its clients, enabling them to achieve their financial goals without the high fees and account minimums typical of traditional investment management. Additionally, Wealthsimple features on-demand financial planning solutions and a hybrid savings and spending product known as Wealthsimple Cash. The company focuses on making financial advice accessible and affordable, supported by a team of experienced financial professionals. As of September 2020, Wealthsimple operates as a subsidiary of Purpose Advisor Solutions Inc.

Hexagon Bio, Inc. is a biotechnology company based in Menlo Park, California, focused on discovering novel drugs for diseases that lack effective treatments. Established in 2016, the company utilizes a data-driven approach that combines genomics, synthetic biology, and computational techniques. By mining genomic data from fungal genomes, Hexagon Bio aims to identify targeted small molecule therapeutics. Its proprietary platform leverages data science to engineer drugs from DNA sequences, enabling the identification of small molecule inhibitors that interact with specific target proteins. This innovative method allows researchers to tap into the global metagenome, facilitating the development of new medicines aimed at improving patient outcomes.

Recursion Pharmaceuticals is a clinical-stage biotechnology company based in Salt Lake City, Utah, focused on transforming drug discovery through the integration of technology, particularly artificial intelligence, automation, and bioinformatics. Founded in 2013, the company utilizes a sophisticated drug discovery platform that includes various software solutions and robotic automation to enhance chemical compound selection, streamline experimental workflows, and evaluate drug efficacy. Key components of this platform involve tools for designing chemical compounds, planning complex experiments, and analyzing data to understand drug interactions and biological responses. By creating one of the largest proprietary biological and chemical datasets, Recursion aims to uncover new biological insights and expedite the development of innovative treatments, ultimately improving patient outcomes.

Castor is an international health-tech company founded by CEO Derk Arts, MD, Ph.D. Their cloud-based clinical data platform simplifies the entire clinical trial process, from recruitment to analysis, for researchers worldwide. More than 50,000 researchers across 90 countries are using Castor to supercharge their research. Castor’s platform has supported more than 4,000 commercial and academic studies that cover a broad range of therapeutic areas including diabetes, cardiovascular disease, rare diseases, infectious diseases, and oncology. Researchers on the platform generate vast amounts of data from traditional and remote trials, and Castor recently reached milestones of 180,000,000 data points and 2,000,000 enrolled patients. Castor’s goal is to make the world’s research data reusable, enabling AI-driven clinical trials, and ultimately creating a future in which they maximize the impact of data through reuse.

Odeko, Inc. is a New York-based company founded in 2019 that offers an inventory management and operations platform tailored for coffee retailers, including cafes, bakeries, and coffee shops. The software assists small business owners in managing inventory, order fulfillment, and customer engagement through features like inventory tracking, sales reporting, and supply chain management. By utilizing data analytics and artificial intelligence, Odeko's platform helps businesses reduce waste, streamline operations, and enhance decision-making. The integration of various payment systems and delivery services further contributes to a seamless experience for both business owners and their customers, enabling independent coffee shops to improve productivity and increase sales.

Ansel Health is a developer of a health insurance platform designed for employers to improve employee benefits through a straightforward supplemental health benefits plan. The company provides insurance services that offer cash payouts to individuals diagnosed with various conditions, including those related to COVID-19. This support helps alleviate financial burdens associated with serious health issues, ensuring that employees have access to necessary resources for recovery.

Brella Ltd. is a Finnish company that specializes in developing a networking platform designed for events, conferences, and live streams. Founded in 2016 and based in Jyvaskyla, Brella's application utilizes a matchmaking algorithm powered by artificial intelligence to facilitate connections among attendees. It enables professionals to discover high-value contacts, such as potential clients, colleagues, investors, and other relevant business connections, thereby enhancing their networking experiences. By streamlining the process of finding and meeting the right people at the right time, Brella aims to simplify and improve the overall effectiveness of networking at various events.

Scaling AI to the Real World.

Flatfile Inc. is a company that specializes in data onboarding solutions, enabling developers to efficiently validate, map, and import CSV data from various web applications. Founded in 2018 and based in Denver, Colorado, Flatfile offers a platform that integrates seamlessly with software applications, allowing users to upload data through formats such as CSV, XLS, or TSV. Its key products include Portal, which provides an import button embedded via a JavaScript snippet, and Concierge, which creates secure collaborative workspaces for organizations to manage complex data ingestion challenges. The platform is designed to enhance developer productivity, reduce costs, and improve data quality by learning to identify and clean incoming data over time. Numerous companies, including AstraZeneca and Square, utilize Flatfile’s API-first platform to streamline their data import processes.

Insitro, Inc. is a data-driven company focused on drug discovery and development, particularly targeting nonalcoholic steatohepatitis (NASH). Founded in 2018 by Daphne Koller and based in South San Francisco, California, Insitro harnesses machine learning and high-throughput biology to revolutionize the process of drug discovery. The company creates extensive functional genomic data sets and integrates them with patient data through innovative machine learning techniques. This approach allows Insitro to build predictive models that enhance target selection, streamline the design of therapeutics, and optimize drug development strategies. By addressing critical challenges in pharmaceutical research and development, Insitro aims to accelerate the delivery of new and effective treatments to patients.

Ansel Health is a developer of a health insurance platform designed for employers to improve employee benefits through a straightforward supplemental health benefits plan. The company provides insurance services that offer cash payouts to individuals diagnosed with various conditions, including those related to COVID-19. This support helps alleviate financial burdens associated with serious health issues, ensuring that employees have access to necessary resources for recovery.

Xilis, Inc. is a biotechnology company based in Chapel Hill, North Carolina, founded in 2019. It specializes in developing advanced organoid technologies aimed at guiding precision therapy for cancer patients and enhancing drug discovery processes. The company's flagship platform, XilisµO, facilitates rapid diagnostics and personalized drug screening while providing scalable, patient-derived models for high-throughput drug discovery. This technology supports physicians and pharmaceutical companies in creating tailored treatments by enabling effective drug screening, ultimately contributing to more precise and cost-efficient cancer therapies.

Comet ML Inc. is a New York-based company that provides a meta machine learning platform designed to assist data science teams and individuals in building reliable machine learning models for real-world applications. The platform enables users to automatically track datasets, code changes, experimentation history, and production models, thereby enhancing efficiency, transparency, and reproducibility in the machine learning process. By allowing data scientists to maintain their preferred workflows while effectively collaborating and tracking previous work, Comet facilitates a more organized approach to experimentation. Additionally, the platform incorporates bayesian hyperparameter optimization, which streamlines the model tuning process and reduces the time typically required for manual adjustments. This comprehensive solution increases visibility into data science efforts and improves the overall effectiveness of machine learning initiatives within organizations.

Remote offers payroll, tax, HR, and compliance solutions tailored for distributed teams. The company has developed a recruiting platform that assists organizations of all sizes in hiring top talent globally. This platform enables human resource executives to recruit individuals without the risk of compliance issues. Additionally, it supports management in project allocation and payment processes, ultimately enhancing productivity and expanding the workforce within client organizations.

Kallyope Inc. is a biotechnology company based in New York City that focuses on the gut-brain axis to develop innovative therapeutics and consumer products aimed at enhancing human health. Founded in 2014, Kallyope employs a multidisciplinary approach, integrating technologies such as sequencing, computational biology, neural imaging, and human genetics to deepen the understanding of gut-brain biology. This comprehensive understanding enables the company to create effective and well-tolerated oral medications targeting various health issues, including diabetes, obesity, gut disorders, inflammatory diseases, migraines, and allergies. With a team of experienced scientists and a strong foundation in drug discovery, Kallyope aims to address significant unmet medical needs through its research and development efforts.

Bark is a software company that provides a parental control monitoring platform aimed at helping parents protect their children online. Founded in 2015 and based in Atlanta, Georgia, Bark employs machine-learning technology to detect potential issues such as cyberbullying, suicidal ideation, and threats related to school violence. The platform monitors children's social media, text messages, and email accounts, alerting parents to significant concerns while minimizing unnecessary information. This targeted approach not only saves parents time but also fosters trust between parents and children. Bark offers actionable recommendations for addressing these issues, empowering parents to manage digital dangers effectively through features like content monitoring, screen time management, and web filtering.

Radar provides a location data infrastructure platform designed for app developers to integrate location-based services into their applications. The platform facilitates the creation of personalized and contextually aware experiences through features such as geofencing, place detection, and location tracking. It supports a variety of use cases across sectors like retail, travel, and logistics, and offers tools for easy integration, including mobile SDKs and APIs. Radar's capabilities include detecting home, work, and traveling locations, as well as geocoding addresses into geographic coordinates. The company emphasizes privacy and security, ensuring responsible handling of location data. Founded in 2016, Radar continues to innovate with new APIs in private beta that enhance the functionality of its platform.

WHOOP is the performance optimization system that tracks recovery, training, and sleeping hours thus helping elite athletes and teams win. The company provides athletes, coaches, and trainers with a continuous understanding of strain and recovery to balance training, reduce injuries, and predict performance. It creates a product that makes individuals and teams perform at a higher level through a deeper understanding of their bodies and daily lives. The WHOOP Strap 3.0 collects physiological data 24/7 to provide an accurate and granular understanding of the body. Aurelian Nicolae, John Capodilupo, and Will Ahmed established WHOOP in 2012 and in Boston, Massachusetts.

NS1 is an internet company that provides accurate control over application delivery that values interaction with customers. They build the world’s most intelligent DNS and traffic management technologies, enabling their customers to take unparalleled control over their traffic and infrastructure as conditions change in application environments and across the global network. They're relentlessly focused on helping their customers succeed in their digital transformation initiatives. Their platform is 100% API driven and DevOps is in their DNA. Through native integrations with leading DevOps tools and vendors, NS1 is removing the barriers to full infrastructure automation. NS1's comprehensive platform technology leverages infrastructure, application, and network data to make intelligent routing decisions in real-time, ensuring optimal application performance and reliability. The company's platform is delivered through its world-class Managed DNS Network for customers including Imgur, MaxCDN, DropBox, SalesForce, and many more.

Suplari, Inc. is a Seattle-based company established in 2016 that focuses on enhancing financial performance and spend accountability for enterprise procurement and finance. By leveraging machine learning, Suplari develops a cloud-based supplier management system that aggregates data from various internal sources, such as contracts, invoices, and usage data. This integration allows for a comprehensive view of suppliers and spending, enabling organizations to proactively manage supplier risk and optimize procurement processes. Suplari’s solutions aim to improve operational intelligence and effectiveness, facilitating better investment in growth and innovation.

Kasisto, Inc. specializes in developing conversational platforms for financial institutions, enabling them to enhance customer engagement through virtual personal assistants. Its flagship product, KAI, is a digital experience platform that supports the creation of branded chatbots and virtual assistants capable of delivering personalized banking experiences across various channels, including mobile apps, websites, and voice-enabled devices. The platform offers tailored solutions such as KAI Consumer Banking, which enhances user interactions, KAI Business Banking, which provides instant access to essential financial information, and KAI Investment Management, which helps users navigate their financial goals through personalized insights. Founded in 2013 and headquartered in New York, Kasisto has additional offices in Mountain View and Singapore, focusing on improving customer experiences in the financial sector through intelligent, human-like conversations.

Recursion Pharmaceuticals is a clinical-stage biotechnology company based in Salt Lake City, Utah, focused on transforming drug discovery through the integration of technology, particularly artificial intelligence, automation, and bioinformatics. Founded in 2013, the company utilizes a sophisticated drug discovery platform that includes various software solutions and robotic automation to enhance chemical compound selection, streamline experimental workflows, and evaluate drug efficacy. Key components of this platform involve tools for designing chemical compounds, planning complex experiments, and analyzing data to understand drug interactions and biological responses. By creating one of the largest proprietary biological and chemical datasets, Recursion aims to uncover new biological insights and expedite the development of innovative treatments, ultimately improving patient outcomes.