TwentyTwo VC

TwentyTwo VC is an early-stage venture capital firm dedicated to investing in a new generation of companies tackling our present and future quality of life. TwentyTwo VC are composed of active investors, investing in people and companies doing great things. We make early-stage investments in companies typically post-launch, pre-seed, seed. We are looking for companies that are solving for quality of life, bringing something new to the table, and executing scalable business models. Beyond that, we seek magnetic, tenacious, adaptable founders who aren’t afraid of the big ideas and ultimately ship great things.

Katherine Caldwell

Founder, General Partner

Past deals in Procurement

Response

Seed Round in 2025
Response Inc. is a technology company based in San Francisco, California, that operates an online platform designed to enhance procurement processes for businesses. Founded in 2018 and backed by Y Combinator, Response focuses on simplifying and optimizing indirect spend for third-party logistics providers, distributors, and retailers. The platform offers features such as real-time SKU-level visibility, automated purchase controls, and actionable insights, which help clients reduce costs, minimize rogue spending, and streamline procurement workflows. By connecting businesses with verified suppliers, including those in the personal protective equipment sector, Response enables effective vendor management and purchasing efficiency. Customers have reported significant savings and reductions in ordering time through the use of Response's services, with the aim of creating a comprehensive digital procurement solution powered by artificial intelligence.

Zip

Seed Round in 2020
ZipHQ offers an intelligent purchase request platform that streamlines the process for employees to initiate purchase or vendor requests. The platform simplifies the creation of purchase requests, automatically routing them for approval across various departments, including procurement, finance, IT, and legal. By integrating with major ERP and P2P solutions, it facilitates the generation of purchase requisitions or draft purchase orders. Additionally, ZipHQ recommends preferred vendors and checks against price benchmarks to enhance cost efficiency and compliance. This comprehensive approach reduces the time spent coordinating approvals, ensuring a smooth and efficient purchasing process for organizations.
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