TwentyTwo VC

TwentyTwo VC is an early-stage venture capital firm dedicated to investing in a new generation of companies tackling our present and future quality of life. TwentyTwo VC are composed of active investors, investing in people and companies doing great things. We make early-stage investments in companies typically post-launch, pre-seed, seed. We are looking for companies that are solving for quality of life, bringing something new to the table, and executing scalable business models. Beyond that, we seek magnetic, tenacious, adaptable founders who aren’t afraid of the big ideas and ultimately ship great things.

Katherine Caldwell

Founder, General Partner

48 past transactions

Response

Seed Round in 2025
Response Inc. is a technology company based in San Francisco, California, that operates an online platform designed to enhance procurement processes for businesses. Founded in 2018 and backed by Y Combinator, Response focuses on simplifying and optimizing indirect spend for third-party logistics providers, distributors, and retailers. The platform offers features such as real-time SKU-level visibility, automated purchase controls, and actionable insights, which help clients reduce costs, minimize rogue spending, and streamline procurement workflows. By connecting businesses with verified suppliers, including those in the personal protective equipment sector, Response enables effective vendor management and purchasing efficiency. Customers have reported significant savings and reductions in ordering time through the use of Response's services, with the aim of creating a comprehensive digital procurement solution powered by artificial intelligence.

Fondo

Seed Round in 2024
Fondo helps with bookkeeping and beyond so founders can grow their businesses with more resources. The company strives to help founders build an enduring business by taking work off of their plate, providing them with the data needed to make key business decisions, and making sure the startup is in compliance at the state and federal level.

Voicepanel

Seed Round in 2024
Voicepanel is a developer of an artificial intelligence-driven platform that facilitates the collection of customer insights through voice conversations. The platform allows businesses to gather detailed feedback on their products and services with ease, using AI to moderate qualitative research. By leveraging voice interactions, Voicepanel enables companies to gain a deeper understanding of their customers' thoughts and emotions, helping them make informed decisions based on valuable feedback.

Greenboard

Pre Seed Round in 2024
Greenboard is a financial software company that develops software to bridge the gap between regulation and financial innovation.

Campfire

Seed Round in 2024
Campfire provides accounting software for startups and midsize businesses. It automates tedious procedures and streamlines workflows to unlock financial information and simplify the monthly close process.

Pirros

Seed Round in 2023
Engineers and Architects end up redesigning hundreds of details a year just because they are unable to search through all their past details. Pirros allows them to effectively manage and search all their past project details so that they can find reasonable starting points rather than starting from scratch.

Vellum

Seed Round in 2023
Vellum is a developer platform for the production of LLM apps.

Infisical

Seed Round in 2023
Infisical is an open-source secret management platform that assists developers in securely managing and synchronizing confidential information across teams, devices, and infrastructures. The platform employs an end-to-end encryption system to prevent the leakage of sensitive data, ensuring that secrets are not exposed through version control systems or insecure communication channels, such as email. By automating the distribution of secrets, Infisical enhances security and efficiency, allowing organizations to maintain the integrity of their confidential information while mitigating the risks associated with secret management.

Psychic

Pre Seed Round in 2023
Psychic is a data integration platform focused on enhancing the capabilities of large language models (LLMs). The company has developed an artificial intelligence support bot that provides a chatGPT-style experience for various products. Its application facilitates the connection of data sources to applications utilizing LLMs, allowing organizations to concentrate on their core application logic while efficiently integrating data into vector databases. This innovative approach streamlines data management and improves the functionality of AI-driven applications.

Gloo

Pre Seed Round in 2023
Gloo is a data search engine that automatically computes multiple embeddings for a single document.

PoplarML

Pre Seed Round in 2023
PoplarML is a company focused on artificial intelligence and machine learning, offering a platform that streamlines the deployment of production-ready, scalable machine learning systems. Its technology allows users to deploy any machine learning model to a fleet of GPUs with minimal engineering effort, transforming complex processes into simple commands. By providing ready-to-use and scalable API endpoints, PoplarML makes it easier for businesses to implement machine learning solutions, thereby broadening access to advanced AI capabilities for a diverse range of users.

Two Dots

Seed Round in 2023
Two Dots is a Santa Monica-based company founded in 2021 that specializes in income verification and fraud prevention for property managers. The company offers a comprehensive platform that provides instant document fraud detection and income verification services, facilitating the underwriting process. Their solutions include identity verification, automatic document collection, tax transcript verification, direct bank account linking, bank statement verification, and paystub verification. By leveraging automation and artificial intelligence, Two Dots aims to enhance the efficiency of underwriters, enabling them to prevent fraud and make informed underwriting decisions.

Tranch

Seed Round in 2023
Tranch is a fintech company based in New York City, founded in 2021 by Beau Allison and Philip Kelvin. The company specializes in providing flexible payment solutions for businesses, enabling them to manage large invoices more effectively. By offering innovative expense financing services, Tranch allows fast-growing businesses, particularly in the SaaS and service sectors, to enhance their cash flow management. This approach prioritizes spending on growth by enabling companies to pay upfront for significant expenses while offering their customers flexible payment options. Tranch aims to simplify and accelerate accounts receivable processes through its advanced payment infrastructure.

Complif

Seed Round in 2022
Complif is a developer of a regulatory compliance platform that assists financial companies in expanding their operations while ensuring compliance with regulations. The platform provides tools for regulatory interpretation, which facilitate the know-your-customer (KYC) and anti-money-laundering (AML) processes. Additionally, it offers solutions for monitoring regulatory obligations, helping firms secure their digital information and minimize regulatory risks in their business activities.

AiPrise

Seed Round in 2022
AiPrise is a platform for KYC orchestration platform that provides customer identity verification solutions. They offer a solution with pre-integrated identity verification and fraud detection APIs to pick and choose from and manage identity stack. Their security services involve KYC, kyb, identity verification, and compliance.

Wolfia

Pre Seed Round in 2022
Wolfia is a company focused on enhancing security reviews for modern businesses, thereby facilitating faster deal closures through the use of generative AI. Their platform automates and streamlines network security compliance, allowing companies to accelerate sales cycles and mitigate third-party risks. Developers benefit from interactive and iterative testing cycles, enabling them to share links to mobile emulators of their applications for immediate feedback on new features. Notable clients such as CircleCI, Solve Intelligence, and Leya leverage Wolfia's solutions to enhance their operational efficiency. The company has attracted investments from prominent venture capital firms, including Khosla Ventures and Y Combinator, highlighting its potential for growth and innovation in the tech industry.

Repool

Seed Round in 2022
Repool is a hedge fund platform that specializes in creating and managing hedge funds for retail investors and emerging managers. The company offers a comprehensive range of services, including fund formation, back-office administration, and investor servicing, all integrated into a single, centralized platform suitable for various asset classes, including equities and cryptocurrencies. By combining technology with traditional fund services, Repool seeks to democratize access to private fund creation and investing for retail traders and non-institutional players. The company has successfully raised over $6.5 million in funding from prominent venture capital firms and founders of notable financial services companies, positioning itself as a modern solution in the hedge fund industry.

Mintlify

Seed Round in 2022
Mintlify is a company that offers an AI-powered platform designed to assist developers in creating engaging and well-structured documentation for their products. By leveraging artificial intelligence, Mintlify automates the generation of documentation directly from code, allowing developers to focus on their core tasks without the burden of manual documentation. The platform is designed to be user-friendly and developer-centric, facilitating the creation of attractive public-facing documentation that enhances user experience and helps customers better understand the products. With over 7,000 companies, including notable names like Anthropic and Zapier, relying on its services, Mintlify aims to streamline the documentation process, ultimately saving time and improving the overall quality of documentation.

Palette

Seed Round in 2022
Palette specializes in sales compensation software that enables companies to create, manage, and automate their compensation plans effectively. The software integrates with customer relationship management (CRM) systems to automatically collect data and track sales performance. This functionality allows enterprises to maintain efficient compensation structures that align with their growth objectives. By streamlining the management of sales commission plans, Palette supports organizations in achieving their business goals.

Beam

Seed Round in 2022
Beam is the infrastructure provider for the fastest growing AI products for companies who need performance, control, and reliability.

Mentum

Seed Round in 2022
Mentum is a company based in San Francisco, California, that provides an API designed for fintech firms, focusing on investment services. In addition to its fintech solutions, Mentum has developed a business intelligence and analytics platform aimed at enhancing supply chain processes for organizations. This platform features customizable dashboards, real-time data visualization, and advanced reporting capabilities, allowing enterprises to analyze complex data sets effectively, improve operational efficiency, and derive strategic insights.

Loops

Seed Round in 2022
Loops is a software-as-a-service (SaaS) company that provides an email-sending platform designed to streamline the process of creating and dispatching emails. The platform features a user-friendly block editor for email design, a code editor inspired by Visual Studio Code, and a selection of pre-built templates. This functionality enables businesses to easily send newsletters, automated messages, and one-off campaigns. By simplifying email communication, Loops aims to enhance the efficiency and effectiveness of its clients' marketing efforts.

Keeper

Seed Round in 2021
Keeper provides software designed to assist bookkeepers in managing their clients' back-office operations more effectively. The application streamlines the month-end closing process by offering an integrated platform that includes a client portal, task management features, file quality assurance tools, and management reporting capabilities. By centralizing these functions, Keeper aims to enhance the efficiency and accuracy of bookkeeping tasks, ultimately supporting professionals in delivering better service to their clients.

Dots

Seed Round in 2021
Dots is a multichannel payouts API that automates manual processes for marketplaces. Dots' API lets a marketplace pay their sellers in the ways they want to be paid, including Venmo, Paypal, ACH and Zelle. As more Americans earn a living by becoming a 1099 worker, marketplaces need to provide flexible payout options and we make supporting these payouts easy through a single API.

Keeper

Seed Round in 2021
Keeper provides software designed to assist bookkeepers in managing their clients' back-office operations more effectively. The application streamlines the month-end closing process by offering an integrated platform that includes a client portal, task management features, file quality assurance tools, and management reporting capabilities. By centralizing these functions, Keeper aims to enhance the efficiency and accuracy of bookkeeping tasks, ultimately supporting professionals in delivering better service to their clients.

Great Question

Seed Round in 2021
Great Question is a customer research platform that streamlines the process of gathering consumer insights for businesses. The platform enables users to recruit participants, conduct various research methods, and synthesize findings in a collaborative environment. By building a panel of customers for interviews, Great Question facilitates direct feedback on prototypes, allowing companies to make informed decisions based on real customer input. This comprehensive approach to research tasks enhances the efficiency of gathering and sharing insights within teams, ultimately supporting better product development and customer engagement.

Treinta

Seed Round in 2021
Treinta is a digital ledger application tailored for microbusinesses in Latin America, where a significant majority still rely on traditional pen-and-paper methods for record-keeping. The app enables users to efficiently track sales, expenses, debts, and inventory while providing real-time insights into key business metrics like cash flow and profitability. By digitizing financial processes, Treinta helps business owners save up to 30 minutes daily on bookkeeping tasks and enhances overall operational efficiency by over 30%. This innovative tool supports the estimated 50 million microbusinesses in the region by facilitating informed decision-making and streamlining financial management.

Finley Technologies

Seed Round in 2021
Finley Technologies is a developer of software that simplifies debt capital raising and management for growing companies. Its platform automates various aspects of debt capital operations, including due diligence and compliance, while centralizing organizational knowledge. This functionality allows customers to effectively manage ongoing reporting with their capital providers. Notable clients, such as Ramp, utilize Finley's solutions to oversee substantial amounts of debt capital. The team at Finley possesses expertise from prominent financial institutions and technology firms, and the company is supported by reputable investors.

ditto

Seed Round in 2021
Ditto allows teams to collaborate on a consistent and effective copy. With Ditto, teams can see edit history and status on individual pieces of text, sync duplicate text, search copy across all designs by text or metadata, and collaborate within and across teams. It is used by non-technical and technical people at numerous companies ranging from small startups to large tech corporations across industry verticals.

Fractional

Seed Round in 2021
Fractional is a platform that facilitates fractional ownership in real estate, making property investing more accessible to a broader audience. By developing an investment application, the company aims to lower the cost of entry and reduce the time commitment traditionally associated with real estate investments. Users can directly own fractions of various investment properties, including single-family and multi-family homes, while also visualizing potential returns, cash flow, and associated costs. The platform allows investors to benefit from rental income and appreciation without incurring annual fees or being bound by a holding period.

Slapdash

Seed Round in 2021
Slapdash is a company that transforms the way users interact with cloud applications by streamlining access and enhancing productivity. Its primary offering is a single interface tool that consolidates various SaaS applications, allowing users to search, organize, and launch files efficiently, similar to traditional desktop environments. The Slapdash Command Bar serves as a central hub for executing daily tasks—such as locating documents, joining meetings, and managing leads—significantly faster than conventional methods. By enabling employees to work across multiple cloud applications seamlessly, Slapdash aims to improve workflow speed and efficiency in modern workplaces.

Whatnot

Seed Round in 2020
Whatnot Inc. operates an online marketplace that specializes in buying and selling authenticated collectibles, including Funko Pops and limited-edition toys. Founded in 2019 and based in Marina Del Rey, California, the company offers a livestream shopping platform where users can discover and trade a diverse range of products, such as fashion, beauty items, and electronics. Whatnot emphasizes community engagement and entertainment, creating a unique shopping experience through features like live shopping and auctions. The platform ensures the authenticity of every product sold, enabling collectors and enthusiasts to safely transact and connect with one another.

Conta Simples

Seed Round in 2020
Conta Simples is a digital financial platform designed to streamline financial transactions for small and medium-sized businesses in Latin America. It combines a checking account, expense management software, and corporate cards into a single solution. This integration allows businesses to manage transfers, withdrawals, and payments efficiently while maintaining control and visibility over their finances. The platform offers a user-friendly interface accessible via mobile and computer, facilitating organized financial management. By providing features that enhance autonomy and decentralize payment processes, Conta Simples aims to simplify financial operations for entrepreneurs and finance teams.

BuildBuddy

Seed Round in 2020
BuildBuddy provides enterprise features for Bazel, an open-source build system that allows users to build and test software. It captures build logs, invocation details, target information, and artifacts so users get a complete picture of each build. The company was founded by Siggi Simonarson and is headquartered in Palo Alto, California.

CoreCare

Seed Round in 2020
CoreCare, Inc. operates an AI-driven software as a service platform tailored for the senior living industry, specifically for Post-Acute and Long-Term Care providers. Founded in 2019 and based in Fort Worth, Texas, the company offers CoreAccess, a solution that simplifies the billing process and alleviates financial complexities for healthcare providers. This platform consolidates provider and payor information systems, standardizing scattered data to identify and rectify inconsistencies efficiently. CoreCare’s CoreAccess Portal aggregates Managed Care Organization data, facilitating easier preparation, submission, reconciliation, and reconsideration of reimbursements. The platform is designed to enhance operational efficiency by increasing admissions, optimizing reimbursement rates, and improving collection metrics, while also reducing administrative burdens. CoreCare has gained the trust of over 1,000 locations nationwide and is backed by Y Combinator, positioning itself as a leader in AI applications for long-term care.

Yotta

Seed Round in 2020
Yotta offers sweepstakes based games. Yotta was founded in 2019 and is headquartered in New York.

Sable

Seed Round in 2020
Sable is a digital banking operator that aims to provide seamless access to financial products for underserved and minority communities, as well as for anyone in need of inclusive banking options. The company offers credit-building cards and no-fee bank accounts that can be established in just five minutes, even for individuals without a credit history, Social Security Number, or U.S. address. This enables newcomers to the United States to quickly initiate their banking experience and gain financial independence. Sable's credit card features enhanced multi-point reporting, allowing users to build credit efficiently while following a transparent path with measurable milestones. This structured approach not only facilitates credit building but also leads to the opportunity for users to graduate to unsecured credit cards, streamlining their journey towards greater financial stability.

SafeBase

Seed Round in 2020
SafeBase, Inc. is a company that specializes in developing cloud-based security software aimed at helping organizations establish effective security programs and enhance their credibility with customers. Founded in 2020 and based in San Francisco, California, SafeBase offers a smart trust center platform that facilitates the sharing of security posture and automates access to sensitive documents. Its key features include SafeBase Inspected, which provides a web badge linked to a custom security status page, as well as custom security checklists and continuous monitoring of security systems. The software also aids companies in configuring their security policies, enabling them to adopt robust security practices efficiently.

Zip

Seed Round in 2020
ZipHQ offers an intelligent purchase request platform that streamlines the process for employees to initiate purchase or vendor requests. The platform simplifies the creation of purchase requests, automatically routing them for approval across various departments, including procurement, finance, IT, and legal. By integrating with major ERP and P2P solutions, it facilitates the generation of purchase requisitions or draft purchase orders. Additionally, ZipHQ recommends preferred vendors and checks against price benchmarks to enhance cost efficiency and compliance. This comprehensive approach reduces the time spent coordinating approvals, ensuring a smooth and efficient purchasing process for organizations.

Jupiter

Seed Round in 2020
Jupiter, Inc. operates as an innovative digital platform that connects food brands with food creators, facilitating the promotion of recipe content. Founded in 2000 and based in San Francisco, Jupiter enables food creators, particularly those with significant followings on social media platforms like TikTok and Instagram, to launch their own grocery-powered recipe stores. These stores are designed to integrate social shopping tools, allowing followers to shop directly from their social feeds. By processing orders through delivery APIs, Jupiter streamlines the purchasing experience for consumers. Additionally, the platform allows food creators to monetize their influence by running brand sponsorships within their stores. Jupiter has successfully partnered with notable food creators, enhancing its reach and impact within the online grocery market.

PostHog

Seed Round in 2020
PostHog is an open-source product analytics platform designed for developers, founded in 2020 and based in San Francisco, California. The platform provides a comprehensive suite of tools that includes product analytics, session recording, funnels, feature flags, and experimentation, all integrated into a single solution. By automating event tracking and user data collection, PostHog enables engineers to understand product usage and user behavior more effectively. This functionality allows development teams to create applications that are better tailored to their users' needs.

Nexu

Seed Round in 2020
Nexu is a financing platform that enables car dealerships to provide a fully digital and real-time financing experience for buyers. The platform employs artificial intelligence and advanced algorithms to facilitate the comparison of automotive loan options, connecting individuals seeking credit with various financial institutions. Users can optimize their search for auto loans through Nexu's portal, where they can review, analyze, and obtain loan offers without incurring any costs. This streamlined approach enhances access to financing for a broader range of car buyers, making the process more efficient and user-friendly.

Airbyte

Seed Round in 2020
Airbyte is an open-source data integration platform that facilitates the synchronization of data from various applications, APIs, and databases to data warehouses. The platform automates the creation of data pipelines using both pre-built and custom connectors, allowing businesses to efficiently gather analytics from all users, including those employing ad-blocking tools. With a focus on simplifying data integration, Airbyte empowers organizations to streamline their data processes and enhance their analytical capabilities.

Sable

Seed Round in 2020
Sable is a digital banking operator that aims to provide seamless access to financial products for underserved and minority communities, as well as for anyone in need of inclusive banking options. The company offers credit-building cards and no-fee bank accounts that can be established in just five minutes, even for individuals without a credit history, Social Security Number, or U.S. address. This enables newcomers to the United States to quickly initiate their banking experience and gain financial independence. Sable's credit card features enhanced multi-point reporting, allowing users to build credit efficiently while following a transparent path with measurable milestones. This structured approach not only facilitates credit building but also leads to the opportunity for users to graduate to unsecured credit cards, streamlining their journey towards greater financial stability.

Shiru

Seed Round in 2019
Shiru, Inc. is a food technology company based in Oakland, California, established in 2019. The company specializes in developing and producing edible proteins aimed at replacing dairy products and eggs in the food industry. By leveraging artificial intelligence and computational design, Shiru creates enhanced proteins that contribute to sustainable food production. The company's focus on using bioinformatics and precision biology allows it to discover novel natural proteins, thereby enabling clients to replace harmful ingredients with healthier alternatives.
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