Trendlines

IBI-Ag is a biotechnology company dedicated to developing innovative bioinsecticides that provide environmentally friendly pest management solutions for farmers. The company focuses on creating natural single-domain antibody insecticides designed to enhance crop production while ensuring the safety of farm workers, consumers, and the environment. By utilizing advanced technology and fermentation processes, IBI-Ag offers efficient and selective pest control solutions that lower agricultural costs. The company's platform is built on thorough testing and extensive learning, allowing farmers to access customized biological pest control strategies that meet their specific needs. Through its commitment to sustainable practices, IBI-Ag aims to revolutionize the agricultural landscape by promoting safer and more effective methods of insect management.

Celleste Bio is a company focused on producing high-quality cocoa ingredients through advanced cell culture techniques. By utilizing naturally occurring cocoa cells, Celleste eliminates the need for traditional cocoa tree cultivation, offering a sustainable alternative for businesses seeking environmentally friendly food ingredients. The company's methods avoid genetic modification and manipulation, ensuring that their products meet high standards of quality and sustainability. This innovative approach not only addresses the challenges of cocoa farming but also provides a reliable source of valuable cocoa components for various applications in the food industry.

AgriG8 is a platform for agricultural fintech that aims to close the financing gap for smallholder farmers. The company's technology combines in-the-moment observation with in-depth behavioral analysis to offer MRV measurement, reporting, and verification capabilities, giving lenders active monitoring and predictive modeling for a profit. making investments in climate-resilient farming more appealing for institutional lenders. Their objective is to make it possible for any farmer who engages in climate-resilient farming to obtain financing.

Peptobiotics is a synbio startup that develops livestock disease prevention biotechnology for sustainable Agri productivity. The company makes agriculture more productive, humane, and sustainable by promoting growth and protecting against pathogens using a new type of antibiotic alternative that does not cause resistance.

ViAqua Therapeutics Ltd is an Israeli company founded in 2014 that specializes in developing innovative drugs and therapeutics for the aquaculture industry. The company focuses on creating the first orally administered treatment designed to combat viral diseases affecting aquatic species, particularly shrimp. ViAqua's proprietary platform employs a unique RNAi nanoparticle formulation that triggers a cellular response to disable viral infections. This technology enables the delivery of coated nanoparticles through feed or immersion techniques, enhancing the resistance of aquaculture species against viral epidemics. With a management team experienced in business development and industrial biotechnology, ViAqua aims to improve the health and sustainability of aquaculture practices.

Insectta, founded in 2017, specializes in producing biomaterials derived from insects, targeting applications in various industries, including agrifood, pharmaceuticals, and electronics. The company aims to foster a circular economy in the insect farming sector by offering high-protein alternatives to traditional pet feeds and developing fertilizers for agricultural use. This innovative approach allows farmers to transform waste into valuable biomaterials, promoting sustainability and enhancing resource efficiency in farming practices.

Celleste Bio is a company focused on producing high-quality cocoa ingredients through advanced cell culture techniques. By utilizing naturally occurring cocoa cells, Celleste eliminates the need for traditional cocoa tree cultivation, offering a sustainable alternative for businesses seeking environmentally friendly food ingredients. The company's methods avoid genetic modification and manipulation, ensuring that their products meet high standards of quality and sustainability. This innovative approach not only addresses the challenges of cocoa farming but also provides a reliable source of valuable cocoa components for various applications in the food industry.

Phytolon Ltd, founded in 2000 and based in Misgav, Israel, specializes in the development of natural food colorants. The company has established a novel and sustainable technology that utilizes fermentation processes with baker’s yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach provides a healthy alternative to synthetic food dyes, offering food manufacturers safe, cost-effective, and stable all-natural colors. Phytolon is dedicated to promoting human health and environmental sustainability through scientific advancement in the food color industry.

TierraSpec is a company that has developed a platform designed to measure and validate carbon sequestration in agricultural soils. Utilizing remote sensing technology, the platform incorporates unique testing methods and advanced machine learning modeling to accurately assess the carbon content in fields. This capability allows farmers to effectively report on their soil's carbon sequestration, facilitating their access to carbon credit markets. By providing these tools, TierraSpec supports sustainable farming practices and contributes to climate change mitigation efforts.

SetBone Medical develops a new bone cement for the treatment of VCF and primarily caused by osteoporosis.

AgriG8 is a platform for agricultural fintech that aims to close the financing gap for smallholder farmers. The company's technology combines in-the-moment observation with in-depth behavioral analysis to offer MRV measurement, reporting, and verification capabilities, giving lenders active monitoring and predictive modeling for a profit. making investments in climate-resilient farming more appealing for institutional lenders. Their objective is to make it possible for any farmer who engages in climate-resilient farming to obtain financing.

FruitSpec Ltd. specializes in designing and manufacturing hyperspectral sensor systems for fruit yield estimation, catering to farmers, distributors, and insurance companies. Founded in 2016 and based in Tel Aviv, Israel, the company offers FruitSpec sensor pods that scan orchards to analyze fruit trees. This technology employs hyperspectral imaging and deep learning algorithms to differentiate between leaves and fruits, generating valuable insights for agribusinesses. FruitSpec provides a comprehensive yield estimation service, which includes scanning the orchard and delivering detailed reports. These reports feature the number of fruits and their size distribution, as well as heat maps indicating fruit quantity distribution within the orchard. By facilitating data collection and yield prediction, FruitSpec enables stakeholders in the fruit value chain to optimize their demand-to-supply processes and make informed business decisions.

Vensica is focused on developing an innovative ultrasound-based drug delivery system aimed at improving the treatment of urinary bladder conditions, particularly bladder cancer and overactive bladder (OAB). Traditional treatment methods involve instilling medication directly into the bladder via a catheter, which can be inefficient and painful. Vensica's approach utilizes ultrasound to enhance drug uptake and penetration into the bladder wall, facilitating a quick and pain-free procedure for patients. This method aims to increase the effectiveness of treatments and reduce the high recurrence rates associated with bladder cancer, which can be as high as 70%. By leveraging ultrasound technology, Vensica seeks to provide safer and more effective treatment options for individuals suffering from these conditions.

Fidmi Medical is an Israeli start-up established in 2014, focused on creating innovative feeding devices aimed at improving nutrition delivery and enhancing the quality of life for patients who cannot consume food orally. The company’s devices are designed to eliminate the drawbacks of existing feeding solutions, providing a secure, reliable, and discreet method for delivering food, liquids, and medications directly into the stomach. With a focus on user-friendly design, Fidmi Medical ensures that its devices allow for easy insertion, replacement, and removal, thereby facilitating better access and management for patients and caregivers alike.

CoreBone specializes in the development of a bioactive bone graft material that is suitable for dental, orthopedic, and spinal applications. The company has created a 100% mineral-based graft that incorporates bioactive minerals, such as silicium, into the skeleton of corals during their natural growth process. This innovative approach enhances healing and improves bone connectivity, offering a robust alternative to traditional bone grafts derived from human or animal sources. By providing a material that possesses essential bone-like qualities—such as strength, porosity, and bioactivity—CoreBone aims to promote natural alternatives while raising awareness about the biological risks associated with conventional graft materials. Founded by CEO Ohad Schwartz and CTO Prof. Itzhak Binederman, CoreBone holds patents and extensive expertise in cultivating coral for medical applications.

AgroScout Ltd. is an Israeli company founded in 2017 that specializes in developing an artificial intelligence-based agricultural intelligence platform. This platform aids farmers by identifying and monitoring crop diseases, ultimately enhancing crop yields and promoting sustainable farming practices. AgroScout's solutions leverage advanced analytics and high-resolution aerial imagery to provide detailed insights into crop health, which helps food production companies optimize their operations for greater profitability. The platform tracks various growth parameters, including plant stand counts and biomass, throughout the growing season. Additionally, it continuously monitors for pests and diseases, facilitating early detection and reducing pesticide use by predicting regional outbreaks. By offering actionable insights into crop management, AgroScout enables farmers to make informed decisions and improve their strategic planning.

Equinom is a food-tech company focused on developing sustainable, non-GMO plant-based ingredients through innovative agricultural practices and advanced technology. It addresses the challenge of inadequate crop production for human consumption, as many crops are traditionally grown for animal feed, requiring costly processing to make them suitable for food. By leveraging its proprietary Manna™ technology platform, Equinom employs artificial intelligence to accelerate the development of high-yield, naturally bred crops that enhance the taste, nutrition, and affordability of meat and dairy alternatives. This approach not only ensures quality and consumer satisfaction but also promotes biodiversity and climate resilience, critical for future food security in the face of climate change. Collaborating with various partners, Equinom has gained recognition as a reliable supplier of premium ingredients, supported by notable investors that bolster its position in the rapidly growing plant-based food market.

IBI-Ag is a biotechnology company dedicated to developing innovative bioinsecticides that provide environmentally friendly pest management solutions for farmers. The company focuses on creating natural single-domain antibody insecticides designed to enhance crop production while ensuring the safety of farm workers, consumers, and the environment. By utilizing advanced technology and fermentation processes, IBI-Ag offers efficient and selective pest control solutions that lower agricultural costs. The company's platform is built on thorough testing and extensive learning, allowing farmers to access customized biological pest control strategies that meet their specific needs. Through its commitment to sustainable practices, IBI-Ag aims to revolutionize the agricultural landscape by promoting safer and more effective methods of insect management.

ViAqua Therapeutics Ltd is an Israeli company founded in 2014 that specializes in developing innovative drugs and therapeutics for the aquaculture industry. The company focuses on creating the first orally administered treatment designed to combat viral diseases affecting aquatic species, particularly shrimp. ViAqua's proprietary platform employs a unique RNAi nanoparticle formulation that triggers a cellular response to disable viral infections. This technology enables the delivery of coated nanoparticles through feed or immersion techniques, enhancing the resistance of aquaculture species against viral epidemics. With a management team experienced in business development and industrial biotechnology, ViAqua aims to improve the health and sustainability of aquaculture practices.

PlanetWatchers, Inc. is a company based in San Francisco, California, that specializes in a platform for geospatial analytics focused on natural asset monitoring. Founded in 2016, PlanetWatchers provides a software-as-a-service solution designed for enterprises, governments, and NGOs across various sectors, including forestry, oil and gas. The company leverages advanced machine learning algorithms and synthetic aperture radar (SAR) technology to transform extensive manual data collection into rapid automated analysis. This capability enables organizations to efficiently monitor their natural assets, delivering critical insights that support the management of large-scale resources and enhance decision-making processes. By utilizing multi-source satellite sensors and elastic cloud infrastructure, PlanetWatchers facilitates effective monitoring and alerting systems that are essential for sectors such as crop insurance, improving accuracy and efficiency in claims validation.

Limaca Medical is developing a game-changer in endoscopic ultrasound-guided biopsy for Precision Medicine.

Phytolon Ltd, founded in 2000 and based in Misgav, Israel, specializes in the development of natural food colorants. The company has established a novel and sustainable technology that utilizes fermentation processes with baker’s yeast cells as biofactories to produce high-quality, plant-based food colors. This innovative approach provides a healthy alternative to synthetic food dyes, offering food manufacturers safe, cost-effective, and stable all-natural colors. Phytolon is dedicated to promoting human health and environmental sustainability through scientific advancement in the food color industry.

Vessi Medical is an Israeli medical device startup focused on innovating treatment for Non-Muscle-Invasive Bladder Cancer (NMIBC) through a novel surface cryotherapy approach. This method employs extreme cold to freeze and eliminate abnormal tissue, addressing the limitations of traditional first-line therapies like TransUrethral Resection of Bladder Tumor (TURBT), which can be invasive, costly, and often result in cancer recurrence. Vessi's technology offers a minimally invasive, office-based therapy that reduces the need for hospital stays and repeat surgeries, which are common in conventional treatments. The system comprises a standalone console and a disposable catheter that allows for targeted cell destruction while safeguarding healthy bladder tissue. Vessi Medical, supported by the Trendlines Group and led by experienced professionals in the medical device and cryotherapy fields, has already shown promising results in animal studies. The company's initial focus is on the $1.2 billion NMIBC market, with plans to expand into treatment options for overactive bladder and urinary tract infections in the future.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

Insectta, founded in 2017, specializes in producing biomaterials derived from insects, targeting applications in various industries, including agrifood, pharmaceuticals, and electronics. The company aims to foster a circular economy in the insect farming sector by offering high-protein alternatives to traditional pet feeds and developing fertilizers for agricultural use. This innovative approach allows farmers to transform waste into valuable biomaterials, promoting sustainability and enhancing resource efficiency in farming practices.

AgroScout Ltd. is an Israeli company founded in 2017 that specializes in developing an artificial intelligence-based agricultural intelligence platform. This platform aids farmers by identifying and monitoring crop diseases, ultimately enhancing crop yields and promoting sustainable farming practices. AgroScout's solutions leverage advanced analytics and high-resolution aerial imagery to provide detailed insights into crop health, which helps food production companies optimize their operations for greater profitability. The platform tracks various growth parameters, including plant stand counts and biomass, throughout the growing season. Additionally, it continuously monitors for pests and diseases, facilitating early detection and reducing pesticide use by predicting regional outbreaks. By offering actionable insights into crop management, AgroScout enables farmers to make informed decisions and improve their strategic planning.

OrthoSpin is developing innovative robotic external fixation system that will improve patient treatment and allow a real-time review to reduce complications and improve clinical outcomes. Dynamic external fixators are mainly used for trauma, bone lengthening and congenital deformities correction. Those systems are cumbersome, painful and require high maintenance. With OrthoSpin’s smart system, physicians are assured that the prescribed course of treatment is being followed. The Company’s proprietary software program allows physicians to chart patient progress and, if required, to easily change the treatment schedule.

AlgaHealth is developing new microalgal sources for the production of high-quality fucoxanthin. AlgaHealth is developing new microalgal sources for fucoxanthin, a novel microalgae cultivation algorithm (15%-50% more efficient), and processing protocols that will produce large quantities of natural, high-quality fucoxanthin at around 20% of the current costs. The company will develop and produce polysaccharides as a by-product, providing a second source of novel, high-value microalgal products. With its innovative method for growing microalgae inland and novel microalgal strains, AlgaHealth will produce commercial levels of fucoxanthin at premium quality, to address the large market demand for quality additives and grab this extensive opportunity.

Equinom is a food-tech company focused on developing sustainable, non-GMO plant-based ingredients through innovative agricultural practices and advanced technology. It addresses the challenge of inadequate crop production for human consumption, as many crops are traditionally grown for animal feed, requiring costly processing to make them suitable for food. By leveraging its proprietary Manna™ technology platform, Equinom employs artificial intelligence to accelerate the development of high-yield, naturally bred crops that enhance the taste, nutrition, and affordability of meat and dairy alternatives. This approach not only ensures quality and consumer satisfaction but also promotes biodiversity and climate resilience, critical for future food security in the face of climate change. Collaborating with various partners, Equinom has gained recognition as a reliable supplier of premium ingredients, supported by notable investors that bolster its position in the rapidly growing plant-based food market.

Aquaculture production is expanding rapidly as marine sources are depleted and fish consumption increases. To meet the growing demand for fish protein, the aquaculture industry needs sustainable solutions that increase fish yields while using existing resources and infrastructures.

ProJini Agchem is developing a solution focused on new type of molecular targets: protein-protein interactions. While such interactions are at the core of any organism, it is very challenging to develop inhibitors for such systems via conventional approaches due to their spatial and chemical characteristics. The platform, developed by scientists Maayan Gal, PhD and Itay Bloch at the Migal Galilee Research Institute Ltd., leverages a combination of computational-biophysical methods to tackle this significant challenge. ProJini Agchem received an exclusive license to use this platform to develop novel pesticides with new modes of action.

BioFishency Ltd. is an Israeli company that specializes in providing a plug-and-play water treatment system for land-based aquaculture. Founded in 2013 and based in Misgav, the company has developed a cost-effective, all-in-one solution that operates with various aquaculture methods, including extensive, intensive, and recirculated systems. BioFishency's technology addresses key challenges in aquaculture, such as limited water availability and the buildup of toxic ammonia, which can hinder fish growth and survival. By enhancing water conditions, the system allows fish farms to significantly increase production—potentially doubling or tripling yields—while utilizing existing infrastructure. This innovative approach not only boosts profitability for fish farmers but also promotes sustainability by minimizing ecological impact and reducing resource expenditures.

The Agency for Science, Technology and Research (A*STAR) is the lead agency for fostering world-class scientific research and talent for a vibrant knowledge-based and innovation-driven Singapore. A*STAR oversees 18 biomedical sciences and physical sciences and engineering research entities, located in Biopolis and Fusionopolis as well as their immediate vicinity. A*STAR supports Singapore's key economic clusters by providing intellectual, human and industrial capital to its partners in industry. It also supports extramural research in the universities, hospitals, research centres, and with other local and international partners.

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

AlgaHealth is developing new microalgal sources for the production of high-quality fucoxanthin. AlgaHealth is developing new microalgal sources for fucoxanthin, a novel microalgae cultivation algorithm (15%-50% more efficient), and processing protocols that will produce large quantities of natural, high-quality fucoxanthin at around 20% of the current costs. The company will develop and produce polysaccharides as a by-product, providing a second source of novel, high-value microalgal products. With its innovative method for growing microalgae inland and novel microalgal strains, AlgaHealth will produce commercial levels of fucoxanthin at premium quality, to address the large market demand for quality additives and grab this extensive opportunity.

ElastiMed Ltd. specializes in the development of innovative medical devices focused on compression therapy, specifically for treating Chronic Venous Insufficiency and preventing Deep Venous Thrombosis. Founded in 2015 and headquartered in Misgav, Israel, the company has created a wearable active compression device that employs advanced smart materials. This device, often referred to as a smart sock, uses electric pulses to compress and massage the legs, enhancing circulation and offering a comfortable and effective treatment solution. It aims to provide an affordable option for patients, particularly the elderly, to alleviate symptoms such as swelling, blood clots, leg ulcers, and sports injuries, thereby improving their overall quality of life.

FruitSpec Ltd. specializes in designing and manufacturing hyperspectral sensor systems for fruit yield estimation, catering to farmers, distributors, and insurance companies. Founded in 2016 and based in Tel Aviv, Israel, the company offers FruitSpec sensor pods that scan orchards to analyze fruit trees. This technology employs hyperspectral imaging and deep learning algorithms to differentiate between leaves and fruits, generating valuable insights for agribusinesses. FruitSpec provides a comprehensive yield estimation service, which includes scanning the orchard and delivering detailed reports. These reports feature the number of fruits and their size distribution, as well as heat maps indicating fruit quantity distribution within the orchard. By facilitating data collection and yield prediction, FruitSpec enables stakeholders in the fruit value chain to optimize their demand-to-supply processes and make informed business decisions.

Gordian Surgical Ltd. is a company based in Misgav, Israel, founded in 2012, that specializes in the development of laparoscopic surgical equipment. The company's flagship product, TroClose 1200, is an integrated port closure solution designed to facilitate the opening and suturing of the abdominal wall during laparoscopic procedures. Gordian Surgical holds three U.S. patents related to laparoscopic trocar, fascial closure systems, and suture anchor deployment methods. These innovations aim to provide surgeons with a simple, secure, and effective means of closing internal tissue layers, enhancing the safety and efficiency of laparoscopic surgeries. The company has developed an initial prototype and has plans to initiate preclinical trials to further test its technology.

EdenShield is an Israel-based AgTech company, established in 2012. Their unique, proprietary, proven plant protection products are helping growers increase and improve their yield of cannabis, vegetable, and flower crops. These organic, safe, chemical free products leverage the naturally protective characteristics found in extracts from native Israeli semi-desert plants. The success of their products lies in their proprietary aromatic ingredients that mask plant odor and lower insect attraction thus eliminating pest born viruses. Additionally, EdenShield products contain important botanical extracts and nutrients, vital for plant health and development.

MetoMotion is developing a multipurpose robotic system, GRoW, for labor-intensive tasks in greenhouses to reduce the reliance on and high costs of human labor in greenhouse vegetable production. The Company’s first application is greenhouse tomatoes.

Hargol™ FoodTech is the world's first commercial grasshopper farm! Grasshoppers are nature's most efficient protein source. Hargol™ FoodTech revolutionize the protein ingredient industry by providing a healthier and more sustainable and affordable alternative, becoming the leading intensive rearing company of grasshoppers in the world. The company is at the forefront of high quality nutrients and healthy grasshoppers supply to markets around the world, improving current market wild-harvested supply by providing year-round availability, nutrients content & quality and costs reduction. For its first line of products, Hargol FoodTech relies on methods and technologies of intensive breeding and growing of three grasshopper species that are processed into protein powders. The company is offering grasshopper based protein ingredient in North America markets to food/ingredient manufacturers and whole grasshoppers. Hargol™ FoodTech have thus far been attracting the interest of food producers, distributors and retailers in the North America, Europe and other regions of the world with whole grasshoppers, grasshopper’s nutrient-rich powder and innovative food products. With the expected 70% rise in demand for animal source protein over the next decades and with existing animal source protein taking a big toll on the environment there is a need for an alternative – Both sustainable and affordable for populations around the globe. Enhanced by their vegetarian diet grasshoppers’ nutrient content is superior compare to other insects or animal source protein: Over 70% whole protein, Omega-3 & Omega-6, Zinc, Iron, & Folic acid. Grasshoppers are also the only Kosher and Halal insect in the world!

Saturas Ltd. is engaged in the development and manufacturing of advanced irrigation sensor systems designed for agricultural applications. Founded in 2013 and based in Misgav, Israel, the company creates miniature stem water potential (SWP) sensors that are embedded in the trunks of trees, vines, and other plants. These sensors provide precise and continuous measurements of water status, allowing farmers to optimize irrigation practices. The Saturas system includes implanted sensors, wireless transponders, and a central control unit that communicates data to farmers' devices, enabling real-time monitoring and management. This technology not only reduces water consumption but also enhances fruit production and quality by tailoring irrigation to the specific needs of crops, thus promoting efficient water use and improving yields.

EdenShield is an Israel-based AgTech company, established in 2012. Their unique, proprietary, proven plant protection products are helping growers increase and improve their yield of cannabis, vegetable, and flower crops. These organic, safe, chemical free products leverage the naturally protective characteristics found in extracts from native Israeli semi-desert plants. The success of their products lies in their proprietary aromatic ingredients that mask plant odor and lower insect attraction thus eliminating pest born viruses. Additionally, EdenShield products contain important botanical extracts and nutrients, vital for plant health and development.

Catalyst AgTech is an Israeli company developing a breakthrough technology which minimizes the environmental impact of agrochemical products, a major issue in modern agrotechnology. Catalyst AgTech's technology solves the conflict between the growing demand for more essential pesticides and the need to prevent any negative impact on the environment. Their solution leads to billions of dollars more business while alleviating environmental contamination. The company is led by an experienced management team and has the scientific backing of the Weizmann Institute of Science. Trendlines Agtech – Mofet is a partner and shareholder of Catalyst AgTech, and Trendlines AgTech is its investor.

Valentis was founded in 2013 and operates within the framework of Trendlines Agtech, part of The Trendlines Group. Valentis has a patent (national phase), covering the use of cellulose nanocrystals (CNC) with a combination of nanoparticles for use in a wide range of applications. In lab tests and limited trials, the Valentis films showed added strength, greater spectral control, improved oxygen barrier and other functionalities. Since July 2014, Valentis has collaborated on new product development with one of Israel’s leading agricultural thermoplastics applications companies.

LapSpace Medical Ltd. is a company based in Misgav, Israel, that specializes in developing devices for laparoscopic surgery. Founded in 2011, it operates under the Misgav Venture Accelerator as part of The Trendines Group. The company has created an inflatable balloon retractor designed to enhance laparoscopic procedures by providing effective and gentle retraction of abdominal organs, such as the intestines. This innovative device minimizes the risk of complications, shortens operating times, eliminates the need for additional assistance, and reduces overall surgical expenses. Consequently, LapSpace Medical's technology enables patients to recover more quickly with minimal incisions.

ApiFix Ltd. develops a minimally invasive system for correcting scoliosis deformities, specifically targeting adolescents with Adolescent Idiopathic Scoliosis (AIS). Founded in 2011 and based in Misgav, Israel, the company focuses on patients classified as Lenke Type 1 or Type 5, who present with a Cobb angle between 35 and 55 degrees. The ApiFix system incorporates a miniature ratchet mechanism that allows for incremental corrections as the patient bends in the desired direction. This approach contrasts with traditional scoliosis surgeries, which typically involve a single, aggressive operation. Instead, ApiFix promotes a gradual correction process that extends over several months, supported by specialized physical therapy. As of April 2020, ApiFix operates as a subsidiary of OrthoPediatrics Corp.

MitrAssist is a company focused on developing innovative solutions for mitral valve regurgitation (MR). It has created a minimally invasive mitral valve implant that enhances the functionality of the natural mitral valve without causing damage. This unique "valve-in-valve" approach allows the implant to work in harmony with the existing valve, offering a treatment option that is neither a repair nor a replacement. MitrAssist's technology addresses the challenges associated with MR and aims to provide a more effective treatment solution for patients. By improving upon current minimally invasive methods, MitrAssist seeks to deliver significant advantages in patient care and outcomes.

Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy drug products that utilize living immune cells to treat cancer and infectious diseases. The company's product portfolio includes AlloStim, an infusion of activated T-Stim cells; CryoVax, an in-situ therapeutic cancer vaccine for patients with metastatic tumors; CRCL, which provides patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine aimed at educating the immune system during cancer remission to prevent recurrence. Immunovative Therapies is engaged in creating treatment protocols for various types of cancer, including hematological malignancies, prostate and breast cancers, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has been supported by the Israel Office of the Chief Scientist and has participated in the Misgav Venture Accelerator program.

InnoLap Surgical develops a device for scarless laparoscopic procedures. The device comprises a handle, thin 3 mm needle, and 5-10 mm detachable and replaceable operating heads. The company was founded in 2012 and is based in Misgav, Israel. As of September 30, 2013, InnoLap Surgical Ltd. operates as a subsidiary of Teleflex Incorporated.

Polytouch Medical specializes in developing advanced technologies for minimally invasive laparoscopic surgery, focusing primarily on hernia repair solutions. Their flagship product, PatchAssist, enhances mesh deployment and placement techniques, particularly for ventral hernias, allowing for quicker treatment initiation and improving the chances of successful outcomes for patients. The company collaborates closely with physicians to refine its offerings, ensuring that products are aligned with clinical needs. Supported by dedicated employees, medical advisors, and a knowledgeable board, Polytouch Medical aims to significantly enhance the quality of care in surgical practices and improve patient outcomes through innovative medical solutions.

Nephera Ltd. is a development-stage medical device company based in Misgav, Israel, founded in 2008. The company specializes in an implantable pulse generator that protects and enhances kidney function in patients suffering from congestive heart failure (CHF) and acute heart failure. Nephera's innovative technology leverages electrical stimulation of the urinary tract to modulate sympathetic nerve activity, which helps maintain renal function and improve the effectiveness of diuretic therapy. This treatment addresses a critical need in managing kidney dysfunction during the frequent hospitalizations of CHF patients, ultimately aiming to preserve kidney health and improve patient outcomes.

Inspiro Medical Ltd. is a medical device company focused on creating an advanced inhalation platform for the delivery of various therapeutic agents. This platform is designed to administer both small molecules, such as corticosteroids and beta agonists, as well as larger macromolecules, including antibodies and vaccines. The company is currently conducting clinical trials involving its proprietary dry powder inhaler, Inspiromatic, specifically targeting asthmatic children. Through its innovative approach, Inspiro Medical aims to enhance treatment options for patients with respiratory diseases.

Stimatix GI is an early-stage startup founded in June 2009, operating under the Misgav Venture Accelerator and jointly funded by the Office of the Chief Scientist. The company has developed a product line known as the Artificial Ostomy Sphincter (AOS), which includes the AOS-1000 and AOS-C2000. These innovative colostomy devices provide patients with the ability to control bowel evacuation, significantly improving their quality of life. The AOS products are designed to seal the stoma, eliminating the issues associated with traditional adhesive bags, and offer a low-profile, aesthetically pleasing solution. By providing users with the autonomy to decide when and where to evacuate, these devices simplify the evacuation process, making it quicker and cleaner. Additionally, the hermetic seal of the AOS products helps prevent skin irritation and folliculitis, addressing common discomforts associated with ostomy care.

ETView Medical Ltd. has successfully combined airway management with continuous direct airway visualization for medical professionals. ETView’s patented single-use single and double-lumen tubes consist of a ventilation tube with an integrated continuous high-resolution video imaging system.

The URINFO 2000 fluid monitoring system is the only feasible solution for the accurate, real-time, and continuous monitoring of urine output. The product is based on FlowSense’s patented optical flow sensing technology. URINFO2000 has been used in the critical care setting to optimize fluid and electrolyte balance, treat acute kidney injury, and prevent renal failure.

VivoText is a digital speech platform specializing in expressive speech creation tailored for the entertainment and media sectors. By utilizing advanced text-to-speech technology, VivoText enables content creators to produce high-quality narration, voiceovers, and complex spoken content with a focus on personalization and scalability. The platform allows for the crafting of virtual human voices, which provides unique interactivity and ensures that creators maintain control over the emotional expression and nuances of the speech output. This innovative approach empowers professionals in industries such as publishing, gaming, and marketing to engage deeply in the speech creation process, ultimately enhancing the impact of their content. With tools that allow for the cloning of voices and the production of lifelike digital speech, VivoText meets the growing demand for customizable audio solutions.

BioSight is a biopharmaceutical company focused on developing innovative cancer-targeted chemotherapy pro-drugs. Founded in 2000 and based in Lod, Israel, BioSight has developed a technology known as S2DOT, which allows for the targeted delivery of chemotherapy drugs directly into cancer cells. This approach significantly reduces the systemic toxicity often associated with traditional chemotherapy treatments. The company’s lead product is a non-toxic conjugate of cytarabine and asparagine, designed specifically for the treatment of acute myeloid leukemia. Through its research and development efforts, BioSight aims to provide safe and effective therapeutic options for patients suffering from hematological malignancies and disorders.

Immunovative Therapies Ltd. is a biopharmaceutical company based in Jerusalem, Israel, focused on developing innovative immunotherapy drug products that utilize living immune cells to treat cancer and infectious diseases. The company's product portfolio includes AlloStim, an infusion of activated T-Stim cells; CryoVax, an in-situ therapeutic cancer vaccine for patients with metastatic tumors; CRCL, which provides patient-specific tumor antigens; and AlloVax, an individualized anti-cancer vaccine aimed at educating the immune system during cancer remission to prevent recurrence. Immunovative Therapies is engaged in creating treatment protocols for various types of cancer, including hematological malignancies, prostate and breast cancers, glioblastoma multiforme, colorectal cancer with liver metastases, kidney cancer, and non-small cell lung cancer. Established in 2004, the company has been supported by the Israel Office of the Chief Scientist and has participated in the Misgav Venture Accelerator program.