T. Rowe Price Group

Epirus, Inc. is a technology company based in Hawthorne, California, specializing in the design and development of advanced defense systems that utilize artificial intelligence and directed energy. Founded in 2018, the company focuses on creating solid-state, software-defined high-power microwave solutions aimed at countering unmanned aircraft systems and other asymmetric threats. Its flagship product, ELECTROMAGNETIC PULSE, serves as a counter-infrastructure solution that can simultaneously target multiple threats, effectively neutralizing drones and swarms. By integrating AI and machine learning with advanced electronics, Epirus enhances the detection and tracking of objects of interest, offering innovative capabilities in electronic warfare and power management for both defense and commercial sectors.

Eikon Therapeutics is a biopharmaceutical company that uses proprietary live-cell imaging platforms to discover and develop therapeutics for chronic and life-threatening diseases. Founded in 2019 and based in Hayward, California, the company applies super-resolution, single-molecule, and real-time molecular-resolution observations to study how compounds interact with individual proteins in living cells. By integrating biology, engineering, and chemistry, Eikon seeks to identify previously intractable targets, accelerate the drug-discovery process, and expand its clinical pipeline through platforms that reveal target biology and compound-protein interactions in their native cellular context.

Clear Labs is a biotechnology company specializing in next-generation sequencing and data analytics for infectious disease surveillance and food safety testing. Its platforms, Clear Dx™ and Clear Safety™, enable rapid identification of pathogens, supporting public health initiatives and enhancing safety across various sectors.

Founded in 2017 and based in Boston, Lightmatter is an artificial intelligence hardware company that specializes in integrated optical technology. It designs photonic chips to enable data processing and communication through light signals, aiming to improve efficiency and scalability for AI data centers.

Element Biosciences develops innovative genetic analysis tools for research and diagnostic markets. Founded in 2017, the company specializes in a disruptive DNA sequencing technology that offers high-quality data, workflow flexibility, and affordable access to next-generation sequencing.

Founded by JB Straubel in Nevada, Redwood Materials specializes in recycling lithium-ion batteries and electronics. It develops processes to extract and refine key materials like lithium, nickel, cobalt, and copper, creating a circular supply chain for electric vehicles and energy storage systems. The company aims to reduce environmental impact and lower production costs by recycling end-of-life products.

FogPharma is a biotechnology company focused on developing innovative therapies for cancer treatment through its proprietary cell-penetrating mini proteins (CPMPs). Founded by Greg Verdine, a leader in drug discovery, the company aims to target cancer-causing proteins within cells that are typically inaccessible to traditional drugs. This novel approach allows for the neutralization of these proteins, potentially transforming the treatment landscape for cancer-related diseases. FogPharma collaborates with leading experts in cancer biology and therapy, fostering a network of researchers, investors, and cancer patients dedicated to advancing its mission. The company is committed to delivering this new class of medicines to improve patient outcomes and enhance quality of life for individuals affected by cancer.

Founded in 2014, Jetti Resources specializes in hydrometallurgical technology for extracting metals from mineral ores. Its proprietary catalytic process is used to efficiently recover copper from low-grade primary sulfides like chalcopyrite, making it a cost-effective and environmentally responsible solution.

Celonis is a company that specializes in execution management, focusing on optimizing and analyzing business processes across various industries, including production, human resources, and logistics. Its core product, the Celonis Execution Management System (EMS), utilizes advanced process mining technology to enhance productivity and streamline operations. The EMS provides a comprehensive suite of tools and applications, including Celonis Studio, designed for business executives and users to effectively manage execution across analytics, strategy, planning, and automation. By offering unique software solutions, Celonis enables organizations to improve process transparency and efficiency, ultimately unlocking their full execution capacity.

Flexe, Inc. operates a cloud-based warehousing services marketplace that connects organizations needing additional warehousing and fulfillment services with those that have excess capacity. Founded in 2013 and headquartered in Seattle, the company specializes in omnichannel logistics, providing solutions for eCommerce fulfillment, retail distribution, same-day delivery, and network capacity. By integrating technology with an open logistics network, Flexe enables retailers, wholesalers, manufacturers, and logistics companies to optimize their operations, address inventory overflow, and streamline material handling. This approach allows clients to enhance their distribution networks by accessing affordable warehouse spaces, thereby maximizing revenue potential while maintaining operational efficiency.

Cross River Bank combines traditional banking with innovative technologies to create compliant financial solutions for fintech companies. It offers personal and corporate banking services, direct lending loans, marketplace lender solutions, flash disbursements, and financial technology solutions.

SandboxAQ specializes in developing advanced artificial intelligence and quantum technology products. The company integrates expertise from diverse fields to create Large Quantitative Models and AI sensing applications, focusing on practical solutions for industries such as financial services, healthcare, and telecommunications.

CelLink designs and manufactures high-conductance, large-area flexible circuits and backplanes for power electronics and solar applications. The company develops flexible conductive backplanes that integrate busing, fusing, voltage and temperature monitoring into a single circuit, enabling efficient power and data transmission. Based in Belmont, California, CelLink serves applications including batteries, LEDs, wire harnessing, and solar cells, aiming to provide reliable, scalable power-management solutions at an affordable price.

Freenome, Inc. is an artificial intelligence genomics biotech company based in South San Francisco, California, founded in 2014. The company focuses on developing accurate, accessible, and non-invasive blood tests for the early detection of cancer and treatment selection. Utilizing a proprietary multi-omics platform, Freenome employs advanced algorithms to analyze cell-free genomic data, which aids in identifying early-stage cancers and other diseases. This innovative approach aims to transform disease management by enabling timely interventions and proactive treatment strategies. In addition to its diagnostic solutions, Freenome also offers clinical research services to further advance cancer detection and management.

Nuro is a technology company that develops autonomous driving technology and self-driving vehicles for local goods delivery. The company focuses on transforming local commerce by enabling merchants to deliver products directly to customers through autonomous delivery systems. Its autonomous driving platform is designed to work across vehicle types and to enable affordable, scalable fleet operations for goods transportation, reducing delivery times and offering a safer, contactless option for last-mile logistics.

Rad Power Bikes LLC, based in Seattle, Washington, is North America's largest electric bike brand, incorporated in 2015. The company designs and manufactures electric bicycles suitable for both on and off-road use, offering feature-rich and affordable options tailored to individual needs. In addition to its bikes, Rad Power Bikes provides a range of accessories, including bags, fenders, racks, and safety products, as well as replacement parts like batteries and tires. Utilizing a direct-to-consumer sales model, the company has experienced rapid growth and aims to democratize electric biking, making energy-efficient transportation accessible and enjoyable for a wide audience. With a team of over 700 employees, Rad Power Bikes is committed to transforming the landscape of electric mobility.

Celonis is a company that specializes in execution management, focusing on optimizing and analyzing business processes across various industries, including production, human resources, and logistics. Its core product, the Celonis Execution Management System (EMS), utilizes advanced process mining technology to enhance productivity and streamline operations. The EMS provides a comprehensive suite of tools and applications, including Celonis Studio, designed for business executives and users to effectively manage execution across analytics, strategy, planning, and automation. By offering unique software solutions, Celonis enables organizations to improve process transparency and efficiency, ultimately unlocking their full execution capacity.

Founded in 2015, Capsule Corporation specializes in online retail of pharmaceutical products. It operates a digital platform that accepts prescriptions from doctors and facilitates delivery of medications to patients.

LUMICKS develops innovative technologies for studying biology and cancer at single-molecule and single-cell levels. Its products include C-Trap Optical Tweezers, Fluorescence Microscopy, and z-Movi Cell Avidity Analyzer, enabling real-time analysis of complex biological processes and interactions.

Color is a healthcare technology company that offers a comprehensive platform for population health management, facilitating equitable and accessible healthcare delivery. The company specializes in large-scale health initiatives, providing solutions that include population genomics programs and high-throughput testing services, such as those for COVID-19. By centralizing essential healthcare capabilities, Color enables businesses, schools, and state public health departments to implement effective preventive health programs, regardless of the geographical distribution of their populations. Its innovative approach addresses various healthcare logistics challenges, streamlining processes related to testing, screening, treatment, and referrals, while creating diverse market opportunities and revenue streams for clinical teams.

Honor operates a large in-home senior care network and technology platform that connects older adults with professional caregivers and home care agencies to deliver high-quality, personalized care in the comfort of their homes. The company combines scalable workforce management and technology with a network of care providers to coordinate reliable, transparent services that support aging in place. Through strategic expansion, including the 2021 acquisition of Home Instead, Honor leverages its platform and global network to improve quality of life for seniors and support families and care professionals.

Seer, Inc. is a life sciences company that specializes in nanoparticle technology solutions aimed at advancing proteomics research. The company offers Proteograph, an integrated system that includes consumables, automation instrumentation, and proprietary software for conducting proteomics analysis. Seer's products are designed for research applications, targeting academic institutions, life sciences laboratories, and biopharmaceutical companies for non-diagnostic and non-clinical uses. Additionally, Seer is focused on developing a health data platform that enhances early detection of chronic diseases by capturing and translating molecular insights from the proteome, thereby enabling healthcare professionals to identify conditions such as cancer and neurological disorders more accurately and rapidly. Founded in 2017 and headquartered in Redwood City, California, Seer was previously known as Seer Biosciences, Inc. before rebranding in July 2018.

Atea Pharmaceuticals is a clinical-stage biopharmaceutical company based in Boston, Massachusetts, focused on discovering and developing next-generation antiviral therapeutics for severe viral diseases. The company's lead candidate, AT-527, is an antiviral agent currently undergoing phase 3 clinical trials for the treatment of COVID-19, caused by the SARS-CoV-2 virus. Additionally, Atea is advancing several candidates in clinical trials, including AT-787 for hepatitis C and AT-752 for dengue, both in phase 2 trials. The company aims to provide innovative treatments for infections caused by RNA and DNA viruses, improving outcomes for patients suffering from serious viral infections. Atea Pharmaceuticals was incorporated in 2012.

RefleXion Medical Inc. is a medical equipment company based in Hayward, California, focused on revolutionizing cancer treatment through its biologically-guided radiotherapy system (BgRT). This innovative technology allows tumors to continuously signal their location during treatment, enabling the simultaneous targeting of multiple tumors, even in cases of metastasized cancer. The RefleXion X1 machine is cleared for various forms of radiotherapy, including stereotactic body radiotherapy, stereotactic radiosurgery, and intensity-modulated radiotherapy. The BgRT system utilizes positron-emission tomography (PET) imaging data to synchronize tumor location information with the linear accelerator, allowing for real-time adjustments in treatment delivery with subsecond latency. RefleXion Medical has established strategic collaborations with Telix Pharmaceuticals Limited and HealthMyne Inc. since its incorporation in 2009.

Color is a healthcare technology company that offers a comprehensive platform for population health management, facilitating equitable and accessible healthcare delivery. The company specializes in large-scale health initiatives, providing solutions that include population genomics programs and high-throughput testing services, such as those for COVID-19. By centralizing essential healthcare capabilities, Color enables businesses, schools, and state public health departments to implement effective preventive health programs, regardless of the geographical distribution of their populations. Its innovative approach addresses various healthcare logistics challenges, streamlining processes related to testing, screening, treatment, and referrals, while creating diverse market opportunities and revenue streams for clinical teams.

Rivian Automotive, LLC is an automotive technology company that specializes in the development and manufacturing of electric adventure vehicles. Founded in 2009 by Robert J. Scaringe, the company is headquartered in Plymouth, Michigan, with additional facilities across multiple locations, including California, Illinois, the United Kingdom, and Canada. Rivian's primary offerings include the R1T, a five-passenger electric pickup truck, and the R1S, a seven-passenger electric sport utility vehicle. The company aims to advance sustainable mobility by creating innovative electric vehicles that redefine traditional automotive economics while providing a comfortable and eco-friendly driving experience.

Seer, Inc. is a life sciences company that specializes in nanoparticle technology solutions aimed at advancing proteomics research. The company offers Proteograph, an integrated system that includes consumables, automation instrumentation, and proprietary software for conducting proteomics analysis. Seer's products are designed for research applications, targeting academic institutions, life sciences laboratories, and biopharmaceutical companies for non-diagnostic and non-clinical uses. Additionally, Seer is focused on developing a health data platform that enhances early detection of chronic diseases by capturing and translating molecular insights from the proteome, thereby enabling healthcare professionals to identify conditions such as cancer and neurological disorders more accurately and rapidly. Founded in 2017 and headquartered in Redwood City, California, Seer was previously known as Seer Biosciences, Inc. before rebranding in July 2018.

Convoy operates an online marketplace for digital freight network services. It connects shippers with local and regional trucks for moving goods efficiently, offering real-time tracking via its mobile app. Founded in 2015, Convoy aims to optimize the trucking industry by reducing waste and emissions.

Checkr is a technology company that builds platforms for the background check industry. It provides screening services such as social security number trace, criminal record checks, driving records, verifications, drug tests, and credit checks, along with continuous monitoring and security infrastructure. The company offers an API and Checkr Connect IDV to integrate identity verification with background checks, enabling faster and more transparent hiring decisions. It serves multiple sectors, including financial services, retail and hospitality, healthcare, higher education, on-demand economy platforms, manufacturing, software and technology, and contact centers and peer-to-peer marketplaces. Founded in 2014, Checkr is headquartered in San Francisco.

Wheels Up is a membership-based private aviation company that specializes in on-demand flight services in the United States. By leveraging data and technology, it connects consumers with safety-vetted private aircraft, offering both programmatic and charter options. The company aims to reduce the upfront costs associated with private flying while providing flexibility, service, and safety to its members. Through its mobile app, users can easily book flights, manage accounts, and access ride-share opportunities. Additionally, members participate in the Wheels Down program, which enhances their travel experiences. Wheels Up operates a diverse fleet, utilizing owned, leased, and chartered aircraft to provide a wide range of global travel alternatives.

Gusto is a SaaS company specializing in Human Capital Management. It offers a comprehensive suite of HR and payroll services, including payroll processing, benefits administration, time tracking, attendance management, and employee onboarding.

Xometry offers an AI-enabled marketplace for on-demand manufacturing services, connecting buyers with manufacturers for efficient sourcing of parts and assemblies. Services include CNC machining, 3D printing, injection molding, urethane casting, die casting, and more.

UiPath designs and develops robotic process automation software for enterprises. Its platform enables hyperautomation through AI-powered discovery of automation opportunities, building and managing automations at scale, running robots across various applications and data, engaging people and robots collaboratively, and measuring operational performance to align with business outcomes.

1stdibs is an online platform connecting respected dealers and makers with collectors of rare furniture, fashion, fine art, jewelry, and home decor. It facilitates transactions through fees from seller marketplace services.

ShockWave Medical is a medical device company focused on developing and commercializing intravascular lithotripsy technology to treat calcified plaque in peripheral vascular, coronary vascular, and valvular diseases. The company markets lithoplasty catheters, including M5 for above-the-knee peripheral artery disease, C2 for coronary artery disease, and S4 for below-the-knee lesions, designed to modify calcium and improve vessel compliance before angioplasty or stent delivery. Its sonic pressure wave technology aims to limit injury to healthy tissue and facilitate procedures such as transcatheter coronary interventions and valve therapies. The business serves interventional cardiologists, vascular surgeons, and interventional radiologists through a direct sales force and distributors. It operates in the United States, Germany, the rest of Europe, and other international markets. Founded in 2009, ShockWave Medical is headquartered in Santa Clara, California.

ServiceTitan is a cloud-based software provider for field service businesses, offering tools to streamline operations, enhance customer service, and drive growth. Its platform caters to industries such as HVAC, plumbing, electrician services, and more in the United States and Canada.

PagerDuty operates a real-time operations platform that harnesses digital signals from various systems and devices, combining them with human response data to orchestrate teams for timely actions. Its solutions include event intelligence, incident response, on-call management, business visibility, and advanced analytics, serving diverse industries worldwide.

Outset Medical is a medical technology company that develops innovative hemodialysis systems. Founded in 2003, it specializes in the Tablo dialysis machine, designed for both acute and chronic settings. The Tablo system features integrated water purification, on-demand dialysate production, software connectivity capabilities, and sensor-based automation.

Evolve Vacation Rental Network, Inc. operates a marketing and booking platform that specializes in vacation rental management services for homeowners and guests. Founded in 2010 and based in Denver, Colorado, Evolve enables homeowners to effectively market and book their vacation properties online. The company offers a range of services, including professional property listings, marketing, guest communications, and local service provider connections. Evolve distinguishes itself by providing homeowners with enhanced performance, lower fees, and greater flexibility compared to traditional property management approaches. Its network of vetted local partners ensures comprehensive support, covering aspects like housekeeping and maintenance. This model aims to maximize rental income for property owners while delivering a seamless travel experience for guests.

Toast is a cloud-based point-of-sale and restaurant-management platform for the food service and hospitality industry. It offers an end-to-end system that combines front-of-house and back-of-house functionality, including tableside ordering, online ordering, delivery tracking, labor management, and real-time reporting. The platform serves a broad range of establishments such as restaurants, bakeries, cafes, bars, nightclubs, and pizzerias, with a focus on mid-market operators primarily in the United States. Toast generates revenue from the sale of restaurant-grade hardware and recurring subscriptions and services tied to transaction volume. As of fiscal 2024, it served approximately 134,000 restaurant locations, and its typical customer generates slightly more than $1 million in annual revenue. The company is headquartered in Boston and maintains additional offices in Portland, Oregon; Omaha, Nebraska; and Dublin, Ireland.

D2iQ develops a datacenter operating system (DCOS) that spans various machines in a datacenter or cloud. It organizes infrastructure, provides scalable application deployment, and supports big data infrastructure on shared resources. D2iQ offers products like Mesosphere DCOS, Infinity, and Conductor, along with architectural consulting services.

Tempus, established in 2015 and based in Chicago, Illinois, is a technology company specializing in precision medicine. It develops a comprehensive library of molecular and clinical data, along with an operating system that makes this information accessible and useful for patients, physicians, and researchers. Tempus offers services such as genomic sequencing, clinical data restructuring, and biological modeling, enabling real-time data-driven decisions for personalized patient care and facilitating the discovery of optimized therapeutic options.

Farmers Business Network is an independent agricultural technology platform that empowers farmers worldwide. It facilitates a farmer-to-farmer network, providing data-driven agronomic insights and tools for confident decision-making to ensure the economic viability of farms while promoting sustainable practices.

Magic Leap is an American startup specializing in Augmented Reality (AR) technology. The company develops proprietary wearable hardware that merges digital imagery with the real world, creating immersive AR experiences indistinguishable from reality. Their innovative Dynamic Digitized Lightfield Signal generates computer-generated 3D images that harmonize with human senses, enabling users to interact with digital devices in a visually cinematic manner. Magic Leap aims to redefine how users access screens and visualize data by combining inherent visual ability with mobile computing technology.

Quanterix is a life sciences company that develops an ultra-sensitive digital immunoassay platform to advance precision health for research and diagnostics. Its Simoa platform employs bead-based and planar array technologies to detect protein biomarkers at very low concentrations in blood, serum, and other fluids that are undetectable by conventional assays. This enables early disease detection, improved prognosis, and more informed treatment decisions in clinical settings and research. The company provides instruments, assay kits, LDTs and assay services, as well as specialized modules and systems such as HD-X automated immunoassay analyzer, aiming to support biomarker analysis across healthcare and life science applications.

AveXis, operating as Novartis Gene Therapies, Inc., is a biotechnology company focused on developing and commercializing gene therapies for rare and life-threatening neurological genetic diseases. Acquired by Novartis in 2018, the company specializes in innovative treatments such as motor neuron cell-targeted gene replacement therapy aimed at conditions like spinal muscular atrophy, Rett syndrome, and amyotrophic lateral sclerosis. These therapies are designed to assist healthcare institutions in addressing diseases that cause progressive muscle weakness, paralysis, and ultimately, death. Through its advancements in gene therapy, AveXis is dedicated to improving the lives of patients and families impacted by these severe genetic disorders.

Warby Parker is a lifestyle brand offering vintage-inspired designer eyewear at affordable prices. It operates as a socially conscious business, with each frame sale funding access to affordable glasses for someone in need.

WeWork is a global commercial real estate company that provides flexible, shared workspaces and related services for technology startups, enterprises, and professionals. It designs and builds physical and virtual workspaces, and offers infrastructure, services, events, and technology to support collaboration, focus, and creativity. The company operates in multiple markets, including India and China, and includes WeWork Labs, which gathers early-stage startups and provides them with space, community, and programming to support their development.

Houzz Inc. is an online platform dedicated to home design and furnishings, connecting homeowners, design enthusiasts, and home improvement professionals globally. Established in 2008 and headquartered in Palo Alto, California, Houzz offers a comprehensive range of services, enabling users to find design inspiration, hire professionals, and shop for home products, including kitchen, bath, and outdoor items. The platform features the largest residential design database in the world, facilitating the sharing of ideas and advice within a vibrant community. Additionally, Houzz Pro provides a Software-as-a-Service solution for professionals in the home remodeling and design sectors, helping them manage their businesses effectively. The company has expanded its reach with offices in key international locations, including London, Berlin, Sydney, Moscow, and Tokyo.

Airbnb operates a global platform connecting hosts with guests seeking short-term accommodations and experiences. It offers private rooms, luxury villas, homes, and unique stays worldwide.

Evernote is a software company that develops note-taking and information-management apps for individuals and teams across mobile devices, tablets, and computers. Its flagship Evernote app provides a single workspace to write, collect, discuss, and present information, while companion tools such as Skitch offer visual annotation, Scannable converts documents to shareable scans, Web Clipper saves web pages with text, links, and images, and Penultimate enables handwriting on iPad. The products synchronize across devices and operating systems to help users capture ideas, organize content, and access it wherever they work. Based in Redwood City, California, Evernote operates as an independent, privately held company with a large global user base, widely used to capture notes, clips, and images and to support solo work as well as collaboration.

Castlight Health is dedicated to simplifying the healthcare experience and promoting healthier, more productive lives. Its health navigation platform integrates with various health vendors, benefits resources, and plan designs, creating a comprehensive application that addresses diverse health needs. By tailoring guidance to individual profiles, Castlight assists users, whether they are healthy, managing chronic conditions, or seeking medical care, in accessing optimal resources. The company aims to help organizations manage rising healthcare costs and enhance the value of their benefits investments. Since its inception, Castlight has introduced innovative solutions such as data-driven price transparency tools and a consumer-friendly wellbeing platform. Currently, it serves millions of users and partners with numerous large employers, positioning itself as a key player in the healthcare sector. Castlight is headquartered in San Francisco.

Upwork operates an online marketplace connecting businesses with independent professionals worldwide. Its platform offers access to diverse skills across various categories, facilitating remote collaboration through communication tools, time tracking, invoicing, and secure payment systems. Upwork serves clients ranging from startups to Fortune 100 companies, generating revenue through talent and client fees.

Apptio, Inc. is a provider of cloud-based Technology Business Management (TBM) solutions designed to assist enterprises in managing their IT investments effectively. Founded in 2007 and headquartered in Bellevue, Washington, Apptio offers a suite of applications that leverage business analytics to deliver insights on technology costs, value, and quality. This enables IT leaders to make informed, data-driven decisions that align technology spending with business outcomes. The company’s solutions encompass cost transparency, benchmarking, operational efficiency, and planning, facilitating automation of IT processes. Apptio's technology operates on a next-generation, in-memory cost analytics platform that aggregates and analyzes data from various financial, operational, and billing sources, providing users with deep visibility into the total cost of IT services. The company serves a global market, with operations in several countries, including the United States, the United Kingdom, Germany, and Australia.

Twitter is a social networking platform that facilitates the exchange of micro-blogs, known as "tweets," which can be up to 280 characters in length. Launched in 2006, it allows users to send and read tweets through various means, including web browsers, SMS, and mobile applications. With over 400 million monthly visitors and 255 million active users, Twitter serves as a global real-time communications platform. Its diverse user base includes world leaders, athletes, entertainers, and news organizations, contributing to its role as a significant source of information and engagement. The platform is available in more than 35 languages and has a strong presence in major cities worldwide, with headquarters in San Francisco and offices across the United States and internationally.

Slide, founded by PayPal co-founder Max Levchin, specializes in creating online applications that enhance user expression on social networking platforms. Originally gaining traction in 2006 by allowing users to easily insert slide shows into their MySpace pages, the company took a significant risk by requiring users to share their MySpace credentials. Despite concerns over potential violations of terms of service, Slide's innovative approach succeeded, leading to a substantial user base. The company has since expanded its offerings to include various widgets for personalization, such as slideshows, images, videos, guestbooks, and virtual gifts, which can be utilized across multiple social networks including Facebook and Bebo. Slide currently boasts over 117 million unique monthly viewers and sees the addition of more than 200,000 new Slide Shows each day, positioning itself as a prominent player in the social media landscape.

CymaBay Therapeutics, Inc., established in 1988 and headquartered in Newark, California, is a clinical-stage biopharmaceutical company dedicated to developing therapies for liver diseases and other chronic conditions with significant unmet medical needs. Its primary focus is on seladelpar (MBX-8025), a selective agonist of peroxisome proliferator activated receptor delta, currently in Phase II trials for treating primary biliary cholangitis, sclerosing cholangitis, and nonalcoholic steatohepatitis. Additionally, the company is developing MBX-2982, an orally-active G protein-coupled receptor agonist targeting gut/liver diseases, and CB-001, a preclinical-stage product candidate for treating gut/liver disease using omega-3 fatty acids. CymaBay has partnerships with Janssen Pharmaceuticals and DiaTex for developing therapies for metabolic diseases and gout, respectively.

Alexza Pharmaceuticals is a specialty pharmaceutical company focused on developing and commercializing proprietary products for the acute treatment of central nervous system conditions. Its product candidates are based on the Staccato system, a hand-held inhaler designed to deliver drugs via inhalation, providing rapid systemic delivery.

In December 1999, Pangea Systems became DoubleTwist, Inc. - a new application service provider (ASP)/ Internet company devoted to empowering life scientists. The change reflects a new focus on this Internet portal. DoubleTwist.com integrates powerful tools and data behind automated research agents that retrieve and interpret data based on the user's scientific questions. The company's traditional data warehousing and mining software power the site, enabling life science research through an easy-to-use interface on the Web. DoubleTwist has established a talented and experienced development team of scientific and technical personnel dedicated to building software solutions that address the biological data management needs of life scientists. DoubleTwist's scientific team is comprised of leading experts in their respective fields of biochemistry, molecular biology, protein chemistry, bioinformatics, computer science and computational biology. They come to DoubleTwist from world-renowned institutions, including Stanford University, UCLA, UC Berkeley, UCSF, University of Pennsylvania, Sandoz Pharmaceutical, Onyx Pharmaceutical, Incyte, Molecular Simulations, Molecular Dynamics, Roche and Glaxo Wellcome. The company's software engineers have extensive experience in commercial-grade software systems, with particular expertise in relational database and object-oriented development. They come to DoubleTwist from some of the industry's most successful companies, including Apple, Oracle and IBM.