Sequoia Capital Israel

Normunity is a biotechnology company that develops precision immuno‑oncology medicines, termed immune normalizers, designed to restore the body’s natural immune response against cancer. Leveraging a partnership with Dr. Lieping Chen’s laboratory at Yale School of Medicine, the company focuses on newly discovered mechanisms of immune disruption, such as the exclusion of T‑cells from immune‑sensitive tumors and other barriers to normal immune function. Its pipeline includes programs targeting these mechanisms to enable clinicians to treat cancer by reactivating the patient’s own immunity. Normunity operates from offices in Boston, Massachusetts, and West Haven, Connecticut.

Positive Sequence Biology is a biotech company with new gene system-based editing, focused on biotech innovation & breakthrough therapies.

Black Jade Star Rock develops organoid-based intelligent equipment and chips. It is a biomedical research and development company with organoid science as its fundamental technology.

Generation Lab aims to enhance human health by developing the first clinically applicable test that assesses an individual's biological age progression and disease risk. This enables longer, healthier lives.

Twin Health, Inc. is a precision health company that focuses on reversing diabetes and chronic diseases through its innovative health platform. Founded in 2018 and based in Mountain View, California, with additional offices in Chennai and Bengaluru, India, the company utilizes artificial intelligence and Internet-of-Things technologies to assess and restore metabolic health. Its platform analyzes complex biosignals from wearable sensors to predict metabolic outcomes and provide tailored treatment recommendations based on individual metabolic profiles. Twin Health has developed unique technology, with several patents granted and pending, that underpins its mission to normalize blood sugar levels and reduce reliance on medications.

Spear Bio is a biotechnology company based in Weston, Massachusetts, founded in 2021. The company specializes in ultrasensitive protein detection technology, which significantly enhances healthcare diagnostics. Its innovative approach enables the quantification of minute protein biomarkers from samples collected at home, facilitating self-testing and telemedicine applications. By allowing clinicians to detect these biomarkers from small sample volumes, Spear Bio's technology integrates seamlessly into existing workflows for sample collection, processing, and detection, thereby improving the overall efficiency of healthcare delivery.

Wuhan Neurophth Biotechnology Co., Ltd. is a pioneering ophthalmology gene drug research and development company based in Wuhan, China, established in 2008. It focuses on gene therapies for ocular genetic diseases, with a particular emphasis on Leber hereditary optic neuropathy (LHON), a condition caused by genetic mutations. Neurophth has made significant advancements in the field, completing the world's first clinical study of gene therapy for LHON in 2011, which involved nine patients and has since observed their progress over seven years. The company aims to develop effective treatments for various ophthalmic disorders, including degenerative optic nerve injuries and vascular retinopathy, thereby providing physicians with innovative therapeutic options for patients suffering from these conditions.

Lingyi Biology is a gene therapy company that uses a platform to validate the functionality of animal models of rare diseases. It is dedicated to sourcing innovation, with a focus on genetic rare diseases like metabolism, CNS, and ophthalmology. Lingyi Biology has a gene therapy and rare disease discovery, development, and industrialization team, as well as a rare disease animal model preparation and verification platform, to address the pain point of a lack of effective animal models for rare disease research and development.

Xunyuan Technology is a bio-refining and bio-manufacturing platform company based on non-grain carbon sources.

HealiRNA develops infectious disease vaccines, tumor vaccines, cell therapy, and protein replacement. They provide mRNA drug research and development, production, clinical trial design, and data analysis services.

MoleculeMind is an AI-driven protein design platform focused on revolutionizing protein discovery, optimization, and design. The company utilizes advanced AI algorithms to enhance the drug development process and has applications across various sectors, including industrial production, agriculture, material design, and environmental improvement. MoleculeMind offers an integrated biological computing platform that enables the prediction and design of peptides, antibodies, enzymes, and small proteins, facilitating industrial-scale protein optimization and design for diverse research and application needs.

Huayuan Regenerative Medicine is the manufacture of implantable bioartificial organs. Huayuan Regenerative Medicine is committed to the research and development, production, and sales of clinical grade stem cells, biological tissue engineering products, and biomanufacturing. Their clinical products include urinary kidney precursor cells, dialysis equipment, and a biosynthetic artificial pancreas.

PhaBuilder is a technology-driven company established in February 2021 by Professor Guoqiang Chen, specializing in synthetic biology with a focus on the engineering application of halophilic microbes. The company employs advanced techniques in Next Generation Industrial Biotechnology to create high-value products such as biodegradable polyhydroxyalkanoates (PHA), ectoine, and cadaverine, targeting multiple sectors, including materials and pharmaceuticals. PhaBuilder is currently constructing two PHA production facilities in China and aims to establish 3-5 large-scale production sites within five years. The company utilizes an interdisciplinary approach that combines biology, engineering, and information technology to transform genetic programs, thereby offering sustainable solutions across diverse fields. With significant backing from notable investors, PhaBuilder is dedicated to integrating synthetic biotechnology into everyday life and advancing intelligent biological manufacturing, with the overarching goal of fostering a greener future through microbial innovation.

Rhegen is engaged in the research and development of mRNA medicine and gene therapy, focusing on synthetic biology technologies to create innovative mRNA drugs and vaccines. The company specializes in platform technologies essential for nucleic acid therapeutics, including mRNA design, synthesis, and non-carrier delivery methods. Rhegen applies these advancements to drug research and development, targeting various clinical indications such as functional protein defects, cancer, and infectious diseases. With a commitment to enhancing drug synthesis and developing novel drug targets, Rhegen aims to contribute significantly to the field of therapeutics, emphasizing both market potential and clinical value.

NeuroXess is a high-tech life science company focusing on flexible electrode BCI (Brain-computer interface) technologies to protect and explore the brain.

Alternative Bio is a biotechnology company focused on developing novel therapeutics targeting a previously untapped class of post-translational modifying enzymes.

GenAssist Therapeutics, founded in July 2020 by a team of leading scientists and industry experts, specializes in the development of gene therapy drugs utilizing advanced base editing technology. The company is focused on addressing neuromuscular diseases that currently lack effective treatments, particularly Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA). GenAssist aims to provide permanent cures by precisely repairing disease-causing genes directly within patients' cells. The company holds global intellectual property rights to its proprietary Targeted AID-based Mutagenesis (TAM) technology, positioning it at the forefront of innovative solutions for a range of genetic disorders.

Cataya Bio (Shanghai) Co., Ltd. is a biotechnology company focused on developing synthetic biological products for various industries. Utilizing an advanced engineering biology platform, Cataya Bio engineers microbes and implements clean fermentation processes to produce high-purity products efficiently and sustainably. The company aims to facilitate the transition from petroleum-based materials to natural and sustainable raw materials, addressing critical global challenges such as environmental preservation, carbon emissions, and climate change. Through its innovative approach, Cataya Bio provides clients with effective solutions for sourcing raw materials that align with contemporary sustainability goals.

XellSmart is a company based in Minhang District, Shanghai, China, focused on developing stem cell treatment solutions for various degenerative diseases that currently lack effective clinical treatments. The firm aims to enhance disease treatment and facilitate drug discovery through innovative stem cell therapies. XellSmart is dedicated to offering large-scale and cost-effective stem cell treatment, replacement, and transplantation options, specifically targeting major conditions like Parkinson's disease. By advancing these solutions, XellSmart seeks to provide patients with viable clinical alternatives to improve their health outcomes.

WuXi Bo Rui Biotechnology develops a radioactive molecular imaging and nuclear drug transformation platform for the precise diagnosis and treatment of tumors. WuXi Bo Rui Biotechnology focuses on the transformation and development of new radionuclide drugs, covering multiple fields of small molecules, peptides, and antibodies, for the diagnosis and treatment of tumors, using their professional platform for targeted precursor design, screening, and radionuclide labeling. While increasing the efficiency of research and development, it also fully utilizes the benefits of accurate nuclear medicine diagnosis and treatment

Demeter Biotechnology is a supplier of microalgae-based products and provides solutions based on microalgae technology for the development of society. It also has a market for microalgae-derived fucoxanthin, EPA, and alternative proteins.

Biosysen operates as a synthetic biology company specializing in species design. It employs software engineering principles to enhance biological productivity through self-replicating, scalable systems. The company's core offerings include artificial species libraries and associated pipelines tailored to specific industrial needs, with a focus on food, daily chemicals, and protein drug research and development.

Frontera Therapeutics is a biotechnology company dedicated to developing and commercializing recombinant virus-based gene therapies. Its mission is to establish an affordable and scalable platform for producing high-quality rAAV therapies, targeting genetic disorders such as those affecting the eye, liver, metabolism, and neuromuscular systems.

Spectrum Medical is a clinical mass spectrometry product platform that promotes clinical mass spectrometry detection technology to the general public. It has an experienced research and development, operations, and sales team, a standardized GMP production workshop, extensive experience in laboratory construction, and a mature laboratory management system. It provides with complete supporting kits in addition to mastering the core mass spectrometry hardware manufacturing technology and equipment integration development capabilities (maternal and child genetics, nutritional levels, therapeutic drug testing, metabolic monitoring, etc.).

NuProbe is a genomics and molecular diagnostics company that develops a platform of reagents and genetic toehold probes for noninvasive nucleic acid profiling. Their Sample‑In Answer‑Out solution integrates cell‑free DNA extraction, qPCR, sequencing and bioinformatics to detect mutations, CNVs, gene fusions and low‑frequency variants with high sensitivity. Founded in 2016, the company operates from Cambridge, Massachusetts and Shanghai, China, and focuses on early detection of cancer and infectious diseases for clinical and research use.

ProfoundBio is a clinical-stage biotechnology company focused on developing novel antibody-based therapeutics with curative potential for cancer, including antibody-drug conjugate candidates targeting solid tumors and hematologic malignancies that are in discovery, preclinical, and clinical development, with programs designed to leverage the immune system to eradicate cancer through targeted therapeutics.

Yueer is a genomics company driven by technology, with a number of revolutionary molecular detection technologies that can reduce the sequencing cost of all NGS platforms and the sensitivity of qPCR, Sanger, and nanopore sequencing. Yueer Gene collaborates with many partners to develop affordable, timely, and accurate genetic analysis tools in order to achieve precision medicine and improve patient outcomes.

Bioforany is a biocatalyst manufacturer focused on the development and sale of innovative biocatalysts for various industries. The company produces a range of products, including chiral alcohols, chiral amines, chiral hydroxy acids, amino acids, chiral epoxides, lipases, oxidoreductases, and epoxidases. Utilizing advanced green biomanufacturing technology, Bioforany offers low-carbon solutions that cater to multiple sectors, such as pharmaceutical intermediates, traditional Chinese medicine decoction components, functional food, animal nutrition, daily chemical care, plant protection, and renewable materials.

MoleculeMind is an AI-driven protein design platform focused on revolutionizing protein discovery, optimization, and design. The company utilizes advanced AI algorithms to enhance the drug development process and has applications across various sectors, including industrial production, agriculture, material design, and environmental improvement. MoleculeMind offers an integrated biological computing platform that enables the prediction and design of peptides, antibodies, enzymes, and small proteins, facilitating industrial-scale protein optimization and design for diverse research and application needs.

Jitai Medicine (METiS) is a biotechnology company that uses artificial intelligence to drive drug delivery and drug discovery. It combines advanced technologies like artificial intelligence, machine learning, and quantum simulation to achieve more effective design of innovative delivery materials, drug candidate selection and formulation design, "programmable nucleic acid drug" development, and nucleic acid delivery design.

METiS Therapeutics is a biotechnology company that aims to drive therapies in a wide range of disease areas by integrating drug discovery and delivery with AI, machine learning, and quantum simulation.

Grit Science is a biotechnology company specializing in gene therapeutics, focusing on the research and development of liver-related genetic treatments. The firm is dedicated to creating innovative medical products that address clinical needs and enhance human health. Through its commitment to advancing biopharmaceutical technology, Grit Science aims to provide effective solutions in the field of genetic medicine.

Lingyi Biology is a gene therapy company that uses a platform to validate the functionality of animal models of rare diseases. It is dedicated to sourcing innovation, with a focus on genetic rare diseases like metabolism, CNS, and ophthalmology. Lingyi Biology has a gene therapy and rare disease discovery, development, and industrialization team, as well as a rare disease animal model preparation and verification platform, to address the pain point of a lack of effective animal models for rare disease research and development.

HemaCell is a biotechnology company specializing in cell therapy, specifically focused on regenerating hematopoietic lineages, which include blood and immune cells, through advanced in vitro techniques. Leveraging innovative stem cell reprogramming, editing, and differentiation technologies, HemaCell aims to address the critical shortage of platelets necessary for treating various diseases such as cancer, liver disease, critical illness, and hematological disorders. The company employs a unique platform that utilizes platelets as drug delivery carriers, facilitating the rapid establishment of induced pluripotent stem cells (iPSCs) and gene targeting technologies. In addition to platelet production, HemaCell is dedicated to developing novel therapeutic solutions for diseases associated with platelet abnormalities, thereby offering effective treatment options and addressing significant medical needs.

Tongxin makes magnetically-suspended artificial blood pumps which are designed to replace the human heart. They are undergoing clinical trials in China after being fast-tracked through the approval process by the National Medical Products Administration, state-run Xinhua News Agency

PhaBuilder is a technology-driven company established in February 2021 by Professor Guoqiang Chen, specializing in synthetic biology with a focus on the engineering application of halophilic microbes. The company employs advanced techniques in Next Generation Industrial Biotechnology to create high-value products such as biodegradable polyhydroxyalkanoates (PHA), ectoine, and cadaverine, targeting multiple sectors, including materials and pharmaceuticals. PhaBuilder is currently constructing two PHA production facilities in China and aims to establish 3-5 large-scale production sites within five years. The company utilizes an interdisciplinary approach that combines biology, engineering, and information technology to transform genetic programs, thereby offering sustainable solutions across diverse fields. With significant backing from notable investors, PhaBuilder is dedicated to integrating synthetic biotechnology into everyday life and advancing intelligent biological manufacturing, with the overarching goal of fostering a greener future through microbial innovation.

Vibrant develops an AI drug development platform to focus on building immune system-related drug pipelines. The company will use artificial intelligence algorithms to accelerate the efficiency of drug development in various aspects such as target discovery, drug design, and drug efficacy evaluation; at the same time, the company expects to continuously improve the success rate of drug development through sustainable data accumulation and algorithm optimization. It was founded and headed by Dr. Wang Luquan and is based in Guangzhou, Guangdong, China.

NeuroXess is a high-tech life science company focusing on flexible electrode BCI (Brain-computer interface) technologies to protect and explore the brain.

Virtue Diagnostics (Suzhou) Co., Ltd. is an in vitro diagnostic (IVD) company based in Suzhou, China, with a research and development office in Singapore. Founded in 2019, the company specializes in developing advanced diagnostic platforms for the detection of infectious diseases, cancer, and chronic diseases. Its technology offerings include clinical mass spectrometry, multiplex immunohistochemistry for pathology-based cancer detection, and a molecular and immunoassay platform. Virtue Diagnostics aims to enhance diagnostic capabilities and improve patient outcomes through its innovative solutions.

Atom Bioscience is a clinical-stage biotechnology company focused on developing innovative treatments for inflammatory and metabolic diseases. Its pipeline includes therapies for chronic gout and non-alcoholic steatohepatitis (NASH).

Jitai Medicine (METiS) is a biotechnology company that uses artificial intelligence to drive drug delivery and drug discovery. It combines advanced technologies like artificial intelligence, machine learning, and quantum simulation to achieve more effective design of innovative delivery materials, drug candidate selection and formulation design, "programmable nucleic acid drug" development, and nucleic acid delivery design.

METiS Therapeutics is a biotechnology company that aims to drive therapies in a wide range of disease areas by integrating drug discovery and delivery with AI, machine learning, and quantum simulation.

Shanghai Duoning Biotechnology Co., Ltd. specializes in the development of serum-free, personalized, and chemically defined cell culture media for the biopharmaceutical industry. Founded in 2005 and based in Shanghai, the company offers a range of products, including basic media, feed media, and cell therapy media. Duoning Biotech is dedicated to providing tailored media development, cell culture process optimization, and commissioned formula production services, utilizing its expertise in animal cell culture concepts. The company supports the research, development, and commercialization of biologics products by delivering comprehensive solutions that encompass technical support and customized services tailored to the needs of pharmaceutical and scientific research institutions.

Wuhan Neurophth Biotechnology Co., Ltd. is a pioneering ophthalmology gene drug research and development company based in Wuhan, China, established in 2008. It focuses on gene therapies for ocular genetic diseases, with a particular emphasis on Leber hereditary optic neuropathy (LHON), a condition caused by genetic mutations. Neurophth has made significant advancements in the field, completing the world's first clinical study of gene therapy for LHON in 2011, which involved nine patients and has since observed their progress over seven years. The company aims to develop effective treatments for various ophthalmic disorders, including degenerative optic nerve injuries and vascular retinopathy, thereby providing physicians with innovative therapeutic options for patients suffering from these conditions.

KingstronBio specializes in the development and manufacturing of advanced heart valve products for cardiac surgeries. The company focuses on creating a comprehensive range of biological heart valves and annuloplasty rings that are designed to be minimally invasive. Utilizing cutting-edge technologies, including anti-calcification and leaflet thinning methods, KingstronBio aims to provide innovative solutions that enhance patient outcomes and improve the overall effectiveness of cardiac procedures.

ComGen Pharma is a biotechnology company that specializes in the research and development of innovative therapeutic drugs targeting the complement system. The company aims to create effective immunotherapies for autoimmune diseases and tumors by focusing on new and key targets within this biological pathway. Recently, ComGen Pharma secured nearly 100 million yuan in financing, which will primarily support phase I clinical trials for its complement inhibitors, advance its drug pipeline, and enhance its innovative drug research and development platform. The financing round was led by prominent investors, including Sequoia China and Yahui Investment, with additional support from Fuchuang Investment and Renyou Investment.

Positive Sequence Biology is a biotech company with new gene system-based editing, focused on biotech innovation & breakthrough therapies.

Structure Therapeutics is a clinical-stage biopharmaceutical company focused on discovering and developing oral small-molecule medicines for chronic diseases with high unmet medical needs. Its platform combines structure-based drug design, computational chemistry, and data integration to create orally available therapies that overcome limitations of biologics and peptide drugs. The company concentrates on targeting G-protein coupled receptors and other mechanisms, leveraging structural insights to identify differentiated, efficacious, and safe treatments. Its programs address cardiovascular, metabolic, and pulmonary conditions, with a focus on delivering convenient, effective medicines that can offer broad patient impact and commercial potential. Structure Therapeutics conducts its research and development activities across its pipeline within a single organization and seeks to advance clinical candidates through development.

magAssist, founded in 2017 by Dr. Xu Bozhen, is a high-tech enterprise based in Suzhou, specializing in the development of in-vitro artificial heart devices aimed at assisting patients with cardiovascular diseases. The company focuses on creating short-term to medium-term ventricular assist devices that are compatible with various blood types. Utilizing advanced fluid mechanics and magnetic suspension technology, magAssist aims to minimize incompatibility issues in patients, thereby enhancing their recovery and treatment processes. The core team consists of leading experts in artificial heart engineering, leveraging extensive experience in research and development to produce domestically manufactured devices with independent intellectual property rights.

Twin Health, Inc. is a precision health company that focuses on reversing diabetes and chronic diseases through its innovative health platform. Founded in 2018 and based in Mountain View, California, with additional offices in Chennai and Bengaluru, India, the company utilizes artificial intelligence and Internet-of-Things technologies to assess and restore metabolic health. Its platform analyzes complex biosignals from wearable sensors to predict metabolic outcomes and provide tailored treatment recommendations based on individual metabolic profiles. Twin Health has developed unique technology, with several patents granted and pending, that underpins its mission to normalize blood sugar levels and reduce reliance on medications.

Geneus develops and commercializes gene sequencers and reagents. The core of its technology is based on the characteristic current signal generated by the interaction of protein nanopores and nucleic acid bases, and it realizes single-molecule nucleic acid sequencing through an integrated chip system.

Cellular Biomedicine Group, Inc. is a clinical-stage biopharmaceutical company focused on developing innovative immunotherapies for cancer and stem cell therapies for degenerative diseases in Greater China. The company employs proprietary cell-based technologies, including various forms of CAR-T therapy, which targets different cancer types, and human adipose-derived mesenchymal progenitor cells aimed at treating joint diseases. Its product pipeline features therapies such as CD20 and CD22 CAR-T for B cell malignancies, and alpha fetoprotein TCR-T targeting hepatocellular carcinoma. Additionally, Cellular Biomedicine is developing knee osteoarthritis treatments, including AlloJoin and Re-Join, the latter having completed Phase IIb trials. The company also engages in broader biopharmaceutical activities, encompassing research and development, technical support, and manufacturing of pharmaceutical polypeptides and medical devices. It has established a partnership with Novartis Pharma AG to produce and supply the CAR-T cell therapy Kymriah in China. Founded in 2001, Cellular Biomedicine Group is headquartered in New York, New York, and draws on a wealth of cellular medicine research and expertise from scientists and clinicians across the United States, England, and China.

Metware is a developer of advanced medical metabolic technology, focusing on metabolomics to enhance life science research and clinical applications. The company specializes in metabolism analysis and testing services, targeting areas such as cancer, metabolic disorders, and infectious diseases. By leveraging innovative metabolism technology, Metware aims to provide effective data analysis that supports patients and facilitates improved treatment options in the medical field.

Bota Biosciences is a global industrial biotechnology company based in Hangzhou, China, founded in 2019. The company specializes in synthetic bioengineering technology for bio-manufacturing, focusing on developing efficient, eco-friendly, and cost-effective biomanufacturing processes. Bota has created an integrative bioengineering platform that connects biological design with scale-up manufacturing, facilitating the production of high-performing industrial compounds through advanced fermentation processes. To support its innovative solutions, Bota has established a pilot plant and manufacturing facility, which enables the company to deliver scalable industrial solutions and market-ready products. Its infrastructure is designed to assist customers and partners across various industries, including nutrition, food, personal care, and animal health. Bota Biosciences is committed to accelerating shifts toward sustainable living by leveraging its multidisciplinary team's expertise to drive impactful biotech innovations.

Joyo Pharma focuses on the research and development of drugs for the treatment of tumors, autoimmunity, metabolism, and infectious diseases.

PhaBuilder is a technology-driven company established in February 2021 by Professor Guoqiang Chen, specializing in synthetic biology with a focus on the engineering application of halophilic microbes. The company employs advanced techniques in Next Generation Industrial Biotechnology to create high-value products such as biodegradable polyhydroxyalkanoates (PHA), ectoine, and cadaverine, targeting multiple sectors, including materials and pharmaceuticals. PhaBuilder is currently constructing two PHA production facilities in China and aims to establish 3-5 large-scale production sites within five years. The company utilizes an interdisciplinary approach that combines biology, engineering, and information technology to transform genetic programs, thereby offering sustainable solutions across diverse fields. With significant backing from notable investors, PhaBuilder is dedicated to integrating synthetic biotechnology into everyday life and advancing intelligent biological manufacturing, with the overarching goal of fostering a greener future through microbial innovation.

Westlake Therapeutics is a biopharmaceutical company based in Hangzhou, China, founded in 2019. The company specializes in developing innovative cell therapies aimed at treating a range of human diseases, including cancer, rare disorders, and immunological and metabolic conditions. Central to its approach is the REDx platform, which enables the engineering of red blood cells and utilizes genetic modifications of hematopoietic stem and progenitor cells sourced from peripheral blood, bone marrow, or cord blood. This technology facilitates the creation of personalized treatment solutions, enhancing the potential for effective therapies tailored to individual patient needs.

Huayuan Regenerative Medicine is the manufacture of implantable bioartificial organs. Huayuan Regenerative Medicine is committed to the research and development, production, and sales of clinical grade stem cells, biological tissue engineering products, and biomanufacturing. Their clinical products include urinary kidney precursor cells, dialysis equipment, and a biosynthetic artificial pancreas.

ProfoundBio is a clinical-stage biotechnology company focused on developing novel antibody-based therapeutics with curative potential for cancer, including antibody-drug conjugate candidates targeting solid tumors and hematologic malignancies that are in discovery, preclinical, and clinical development, with programs designed to leverage the immune system to eradicate cancer through targeted therapeutics.

neoX Biotech is a Beijing-based biotechnology company founded in 2018 that specializes in the development of antigen-based cancer vaccines. By integrating artificial intelligence with biophysics, neoX Biotech focuses on the discovery and development of macromolecular and multispecific drugs, primarily in the field of immuno-oncology. The company has established a platform for early therapeutic discovery, which includes neoantigen prediction and T cell receptor screening, as well as the characterization of protein-protein interactions. This innovative approach aims to provide effective treatments for cancer patients by advancing drug research and development.

Biosysen operates as a synthetic biology company specializing in species design. It employs software engineering principles to enhance biological productivity through self-replicating, scalable systems. The company's core offerings include artificial species libraries and associated pipelines tailored to specific industrial needs, with a focus on food, daily chemicals, and protein drug research and development.

MoonBiotech is a biotechnology company focused on the commercialization of microbial resources.

Insilico Medicine, Inc. is a biotechnology company that leverages artificial intelligence (AI) to transform drug discovery, biomarker development, and aging research. Founded in 2014 and based in Baltimore, Maryland, the company has established itself as a pioneer in applying advanced AI techniques, such as generative adversarial networks and reinforcement learning, to create novel molecular structures for various diseases, including cancer and age-related conditions. Insilico Medicine operates an integrated platform that covers all stages of drug discovery, from initial research to clinical trial analysis. Its projects include Pharma.AI, which offers machine learning services to various sectors, and Young.AI, a platform focused on aging predictors. The company also pursues internal drug discovery initiatives targeting diseases like Alzheimer's and Parkinson's, and has partnered with Life Extension to produce nutraceutical products utilizing deep learning and bioinformatics. Additionally, Insilico Medicine provides consumer applications aimed at enhancing health and longevity.

HiFiBiO is a biotherapeutics company focused on harnessing the human immune system to address diseases, particularly cancer and autoimmune disorders. Founded in 2013 and based in Paris, the company specializes in proprietary single-cell technologies that facilitate drug and biomarker discovery and development. HiFiBiO's platform combines extensive biological knowledge with advanced single-cell profiling techniques, allowing for the rapid identification and advancement of antibody drugs. Through partnerships with both industry and academic institutions, HiFiBiO aims to promote open innovation and enhance patient outcomes by unlocking the therapeutic potential of the immune system.

Stemirna Therapeutics is a RNA technology based drug development company designed to maximize the potential of RNA science. The company currently has more than a dozen of independently-developed mRNA drug projects, focusing on the fields of mRNA-based personalized cancer vaccines, mRNA vaccines for infectious disease, protein defects diseases, and genetic diseases, providing cure and solutions for cancer and infectious diseases, better serving patients.

Analytical Biosciences is a developer of single-cell genomics focused on creating precise maps of human diseases. The company collaborates with medical research institutions, hospitals, and pharmaceutical firms to leverage single-cell genomics and bioinformatics for improving disease diagnosis and treatment. By conducting large-scale systematic mapping of diseases at the single-cell level, Analytical Biosciences engages in extensive data mining to support its partners in discovering new therapeutic targets and developing innovative treatment strategies. Utilizing high-resolution databases and advanced data analytics, the company aims to unlock disease mechanisms and facilitate the identification and validation of novel cellular targets and biomarkers. This approach positions Analytical Biosciences at the forefront of advancing next-generation therapeutics and diagnostics.

Phanes Therapeutics is a biotechnology company specializing in drug discovery for immuno-oncology and eye diseases. Established in 2016, the company focuses on developing monoclonal antibodies for solid tumors and conditions like age-related macular degeneration, diabetic macular edema, and diabetic retinopathy. Additionally, they work on bispecific antibodies targeting small cell lung cancer.

EdiGene Inc. is a biotechnology company specializing in the development of genome editing technologies for therapeutic applications in cancer and various genetic diseases. Founded in 2015 and headquartered in Beijing, China, with additional offices in Guangzhou and Cambridge, Massachusetts, EdiGene focuses on both ex vivo and in vivo gene-editing therapies. The company has established proprietary platforms for editing hematopoietic stem cells and T cells, as well as an RNA base editing approach for in vivo applications. EdiGene's innovative methods enable targeted modifications of genetic information in human cells and facilitate high-throughput drug discovery through advanced screening techniques. By translating these technologies into novel therapeutics, EdiGene aims to improve the safety and efficacy of gene therapy, ultimately benefiting patients, the pharmaceutical industry, and the scientific research community.

VivaVision Biotech is a clinical-stage R&D biopharmaceutical company that is developing novel medicines to treat topical diseases. VivaVision Biotech is dedicated to bringing new therapeutics to millions of patients suffering from chronic ocular or dermal inflammatory diseases.

Benchling, Inc. delivers a cloud-based informatics platform for life sciences research and development. The platform unifies experiment design, data capture, and collaboration in a single interface, enabling scientists to design, record, and share experiments. It consists of an integrated lab notebook, a biological registration system to track inventory such as plasmids, antibodies, and cell lines, and a molecular biology design and analysis suite that supports end-to-end R&D workflows. Additional modules include Benchling Insights for querying and visualizing structured data and collaboration around it, and Bioregistry for biological entity registration and strain management. Benchling serves researchers in biotechnology and pharmaceutical companies as well as academic and government labs, including research and development managers and principal investigators who need centralized data management and streamlined collaboration. The platform is applied across antibodies, cell therapy, gene therapy, proteins and peptides, vaccines, and industrial biotechnology. Founded in 2012 and based in San Francisco, Benchling enables scientists to design DNA, manage workflows, and accelerate decision-making throughout the R&D lifecycle.

PackGene Biotech is a United States-based contract research organization and contract development and manufacturing organization that specializes in viral vectors for gene therapies. The company focuses on adeno-associated virus (AAV) vector design, cloning and packaging, as well as production of AAV, lentiviral vectors, mRNA, and plasmid DNA. It serves early-stage drug discovery, preclinical development, and cell and gene therapy trials, delivering scalable, cost-effective production with emphasis on purity, titer and infectivity. PackGene offers customized vector design, construction, and packaging services to support researchers in accelerating gene therapy programs.

OnCusp Therapeutics is a biopharmaceutical company dedicated to accelerating oncology medication innovation globally. It focuses on translating preclinical drug candidates into clinical proof-of-concept stage and advancing them for rapid global early clinical development.

Qihan Biotech is a biomedical company specializing in genetic technology with a focus on addressing the global shortage of organ donors. The company aims to produce safe and effective cells, tissues, and organs for human transplantation using advanced gene editing techniques. By applying these technologies to xenogenic organ transplantation, Qihan Biotech seeks to create organs that can be transplanted into humans, thereby reducing the need for traditional organ transplants and saving lives.

Neuracle is a prominent enterprise in China's neuroscience sector, specializing in neural monitoring and diagnostic technology. Leveraging advanced brain-machine interface technology developed through collaboration with Tsinghua University, Neuracle focuses on innovative research in neuroscience, psychology, and neuroengineering. The company provides comprehensive solutions for the diagnosis, treatment, and rehabilitation of clinical neurological diseases. Its product offerings include digital electroencephalographs and other tools that allow healthcare institutions to monitor patients' brain bioelectricity levels and accurately diagnose neural conditions. Neuracle's research and development efforts have garnered acceptance from experts in both neuroscience and clinical medicine, positioning the company as a leader in its field and a key contributor to national science and technology initiatives.

Wuhan Neurophth Biotechnology Co., Ltd. is a pioneering ophthalmology gene drug research and development company based in Wuhan, China, established in 2008. It focuses on gene therapies for ocular genetic diseases, with a particular emphasis on Leber hereditary optic neuropathy (LHON), a condition caused by genetic mutations. Neurophth has made significant advancements in the field, completing the world's first clinical study of gene therapy for LHON in 2011, which involved nine patients and has since observed their progress over seven years. The company aims to develop effective treatments for various ophthalmic disorders, including degenerative optic nerve injuries and vascular retinopathy, thereby providing physicians with innovative therapeutic options for patients suffering from these conditions.

neoX Biotech is a Beijing-based biotechnology company founded in 2018 that specializes in the development of antigen-based cancer vaccines. By integrating artificial intelligence with biophysics, neoX Biotech focuses on the discovery and development of macromolecular and multispecific drugs, primarily in the field of immuno-oncology. The company has established a platform for early therapeutic discovery, which includes neoantigen prediction and T cell receptor screening, as well as the characterization of protein-protein interactions. This innovative approach aims to provide effective treatments for cancer patients by advancing drug research and development.

Jifan Biotechnology is a biotechnology firm that provides molecular biology reagents, diagnostic raw materials, and kits for research.

NuProbe is a genomics and molecular diagnostics company that develops a platform of reagents and genetic toehold probes for noninvasive nucleic acid profiling. Their Sample‑In Answer‑Out solution integrates cell‑free DNA extraction, qPCR, sequencing and bioinformatics to detect mutations, CNVs, gene fusions and low‑frequency variants with high sensitivity. Founded in 2016, the company operates from Cambridge, Massachusetts and Shanghai, China, and focuses on early detection of cancer and infectious diseases for clinical and research use.

Visen Pharmaceuticals is an innovative biopharmaceutical company focused on developing and providing advanced treatments for endocrine diseases in China. With a patient-centric approach, Visen aims to deliver first-in-class or best-in-class products, covering both common and rare endocrine conditions in adults and children. The company leverages cutting-edge technologies and global resources, with established offices in Shanghai, Beijing, Hong Kong, and Taipei, along with a Greater China R&D and manufacturing site in Suzhou.

Positive Sequence Biology is a biotech company with new gene system-based editing, focused on biotech innovation & breakthrough therapies.

SciNeuro Pharmaceuticals is a biotechnology company based in Shanghai, China, focused on developing innovative medicines for patients with central nervous system (CNS) diseases. The company is committed to transforming the treatment landscape for these conditions through a robust product pipeline that emphasizes internal innovation and global collaboration. SciNeuro's drug development is guided by breakthrough scientific evidence, including insights from human genetics and pharmacology, targeting the underlying mechanisms of CNS diseases. By addressing these pathological mechanisms, SciNeuro aims to provide transformative therapies that not only aim to cure these diseases but also enhance the quality of life for patients.

METiS Therapeutics is a biotechnology company that aims to drive therapies in a wide range of disease areas by integrating drug discovery and delivery with AI, machine learning, and quantum simulation.

D3 Bio, established in 2020, is a biotechnology company headquartered in China. It specializes in the development and registration of innovative medicines, primarily focusing on oncology and immunology. The company's approach involves analyzing clinical and market data to identify gaps in current treatments, employing unique drug development methodologies to target new disease areas and routes, and ultimately providing patients with alternative therapeutic options.

PackGene Biotech is a United States-based contract research organization and contract development and manufacturing organization that specializes in viral vectors for gene therapies. The company focuses on adeno-associated virus (AAV) vector design, cloning and packaging, as well as production of AAV, lentiviral vectors, mRNA, and plasmid DNA. It serves early-stage drug discovery, preclinical development, and cell and gene therapy trials, delivering scalable, cost-effective production with emphasis on purity, titer and infectivity. PackGene offers customized vector design, construction, and packaging services to support researchers in accelerating gene therapy programs.

EdiGene Inc. is a biotechnology company specializing in the development of genome editing technologies for therapeutic applications in cancer and various genetic diseases. Founded in 2015 and headquartered in Beijing, China, with additional offices in Guangzhou and Cambridge, Massachusetts, EdiGene focuses on both ex vivo and in vivo gene-editing therapies. The company has established proprietary platforms for editing hematopoietic stem cells and T cells, as well as an RNA base editing approach for in vivo applications. EdiGene's innovative methods enable targeted modifications of genetic information in human cells and facilitate high-throughput drug discovery through advanced screening techniques. By translating these technologies into novel therapeutics, EdiGene aims to improve the safety and efficacy of gene therapy, ultimately benefiting patients, the pharmaceutical industry, and the scientific research community.

Dizal Pharmaceutical is a research-driven biotechnology company that specializes in the discovery, development, and commercialization of innovative medicines. The company focuses on creating first-in-class and best-in-class therapeutic solutions, emphasizing the development of groundbreaking drugs. With a commitment to advancing healthcare, Dizal engages in extensive research and development activities, alongside production and sales of its pharmaceutical products. Through its efforts, Dizal aims to contribute significantly to the pharmaceutical industry by delivering effective treatments that address unmet medical needs.

LP Pharmaceuticals (Xiamen) Co., Ltd., located in Xiamen Biomedical Industry Base which formulates and manufactures pharmaceuticals with enhanced delivery properties. The company was founded in 2012 by a group of scientists and business professionals with extensive experience in the US and Chinese pharmaceutical industry. Proprietary delivery platforms include mucosal and oral controlled release. Therapeutic areas currently concern central nervous system, digestive system, cardiovascular, cancer and AIDS.

neoX Biotech is a Beijing-based biotechnology company founded in 2018 that specializes in the development of antigen-based cancer vaccines. By integrating artificial intelligence with biophysics, neoX Biotech focuses on the discovery and development of macromolecular and multispecific drugs, primarily in the field of immuno-oncology. The company has established a platform for early therapeutic discovery, which includes neoantigen prediction and T cell receptor screening, as well as the characterization of protein-protein interactions. This innovative approach aims to provide effective treatments for cancer patients by advancing drug research and development.

Simcha Therapeutics is a biopharmaceutical company focused on developing engineered cytokine immunotherapy for cancer treatment. Founded in 2018 and headquartered in New Haven, Connecticut, the company utilizes directed evolution to create novel cytokines that enhance the immune system's ability to combat diseases. Its lead program, ST-067, is a designer IL-18 cytokine that has demonstrated significant antitumor effects in animal models, both as a standalone treatment and in combination with anti-PD-1 checkpoint inhibitors. This innovative approach aims to provide patients with more effective immunotherapies, thereby improving their ability to fight cancer.

JW Therapeutics (Shanghai) Co., Ltd. is a biotechnology company based in Shanghai, China, specializing in the development, transformation, and promotion of cell-based immunotherapies. The company focuses on innovative therapies that utilize chimeric antigen receptor (CAR) and T cell receptor (TCR) technologies to enhance the body's immune response against cancer. JW Therapeutics is dedicated to creating transformative treatments for both hematological cancers and solid tumors, with its lead product candidate being relmacabtagene autoleucel, a CAR-T therapy targeting anti-CD19. By advancing these groundbreaking therapies, JW Therapeutics aims to improve survival rates and quality of life for cancer patients.

Atom Bioscience is a clinical-stage biotechnology company focused on developing innovative treatments for inflammatory and metabolic diseases. Its pipeline includes therapies for chronic gout and non-alcoholic steatohepatitis (NASH).

Buymed operates a digital pharmaceuticals distribution platform in Vietnam, known as Thuocsi.vn. Founded in 2018 and based in Ho Chi Minh City, the platform supplies a wide range of healthcare products, including medicines, cosmetics, medical devices, and supplements. It serves over 1,000 pharmacies and clinics across the country, offering detailed product information such as pricing and active ingredients. Additionally, Thuocsi.vn features a communication network that provides important updates, including product recalls. The company is recognized as a successful startup in the medical technology sector, attracting young talent eager to integrate advanced technology into healthcare solutions.

SiBionics is a medtech company headquartered in Shenzhen, China, focused on the research, development, and commercialization of active implantable medical devices and medical artificial intelligence. The company specializes in innovative solutions for medical imaging and neuromodulation, striving to create cost-effective products that enhance long-term health monitoring and disease management. SiBionics is developing various advanced technologies, including implanted retinal electrical stimulators, continuous glucose monitoring systems, and screening tools for gastric cancer and chronic diseases. Through the integration of visual coding, artificial intelligence, and medical big data, SiBionics aims to address critical health issues such as retinitis pigmentosa, diabetes, cardiovascular and cerebrovascular diseases, and gastrointestinal tumors, ultimately improving diagnostic and treatment options for these conditions.

Wuhan Neurophth Biotechnology Co., Ltd. is a pioneering ophthalmology gene drug research and development company based in Wuhan, China, established in 2008. It focuses on gene therapies for ocular genetic diseases, with a particular emphasis on Leber hereditary optic neuropathy (LHON), a condition caused by genetic mutations. Neurophth has made significant advancements in the field, completing the world's first clinical study of gene therapy for LHON in 2011, which involved nine patients and has since observed their progress over seven years. The company aims to develop effective treatments for various ophthalmic disorders, including degenerative optic nerve injuries and vascular retinopathy, thereby providing physicians with innovative therapeutic options for patients suffering from these conditions.

CERo Therapeutics is a biotechnology company focused on cellular immunotherapy and next-generation engineered T cell therapeutics for cancer. It develops platforms that integrate innate and adaptive immune programs to enhance anti-tumor activity and engage the body's full immune repertoire. The company was incorporated in 2016 and is headquartered in San Francisco, California. Its lead product, CER-1236, is an autologous T-cell therapy targeting a novel tumor antigen, TIM-4 ligand.

Adagene is a clinical-stage biotechnology company focused on developing immuno-oncology antibodies targeting novel epitopes. It employs its proprietary Smart Antibody Technology to enhance success rates, expedite time to market, and reduce development costs for therapeutic antibodies.

Transcenta Holding is a clinical-stage biopharmaceutical company that offers fully integrated capabilities in antibody discovery, research and development, manufacturing, and business development. The company concentrates on developing innovative antibody-based therapeutics for oncology and selected non-oncology indications, including bone and kidney disorders, with a pipeline that includes Osemitamab (TST001), TST002, TST003, TST006, MSB2311, MSB0254, TST808, and other candidates. Headquartered with multiple sites in China—Suzhou, Shanghai, Hangzhou, and Beijing—and with research and development and operations in the United States at Waltham and Princeton, Transcenta operates as a global biotherapeutics business. Founded in 2019, the company aims to advance therapeutic antibodies through discovery, development, and manufacturing to address unmet patient needs. Its business scope encompasses clinical research and trial services alongside its development programs, positioning it to accelerate pipeline progress and collaborate on global opportunities.

RootPath Genomics, Inc. is a biotechnology company founded in 2017 and headquartered in Cambridge, Massachusetts. The company specializes in developing a next-generation T-cell therapy platform that integrates precision medicine with cancer immunotherapy. By focusing on the analysis and manipulation of individual immune cells, RootPath aims to enhance immune responses and improve cell therapy efficacy. Its innovative technologies allow for precise monitoring and modulation of the immune system, which is intended to revolutionize the diagnosis and treatment of cancer.

BGI is a biotechnology company specializing in genomics. It provides genome sequencing and genetic testing services to research institutions and healthcare professionals worldwide. The company's offerings include bioinformatics, multi-omics solutions, and related tools, catering to a diverse range of clients such as pharmaceutical companies and academic institutions. BGI's work has contributed significantly to genetic and genomic research, with notable collaborations including Eli Lilly and Company, Merck, Pfizer Inc., and the Bill & Melinda Gates Foundation.

ViGeneron develops innovative gene therapies focused on treating ophthalmic diseases with significant unmet medical needs. Its pipeline is built on two proprietary adeno-associated virus (AAV) technology platforms: vgAAV, enabling superior transduction efficiency and less invasive treatment administration, and REVeRT, targeting diseases caused by mutations in large genes.