Pontifax

Lutris Pharma is a biopharmaceutical company based in Tel Aviv-Yafo, Israel, focused on developing innovative therapies to enhance the effectiveness of anti-cancer treatments. Established in 2015, the company has created a proprietary small molecule drug known as LUT014, which acts as a topical B-Raf inhibitor. This drug facilitates the use of epidermal growth factor receptor (EGFR) inhibitors while minimizing the common cutaneous side effects typically associated with such treatments. By addressing these side effects, Lutris Pharma aims to improve both the efficacy of anti-cancer therapies and the overall quality of life for patients undergoing treatment with EGFR inhibitors.

V-Wave Ltd. is a medical technology company specializing in the development of percutaneous implantable therapeutic devices for patients with chronic heart failure. Established in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave aims to address the needs of patients who continue to experience severe symptoms or require hospitalization despite optimal medical treatment. The company's flagship product is the V-Wave Shunt, a biocompatible, inter-atrial unidirectional implant designed to alleviate symptoms related to chronic heart failure by regulating Left Atrial Pressure. This innovative device seeks to improve patients' quality of life by reducing hospitalizations, enhancing exercise capacity, and ultimately providing symptomatic relief. V-Wave's team comprises experienced engineers and medical scientists dedicated to advancing the field of cardiovascular devices.

EyeYon Medical is an Israeli startup based in Jerusalem, developing innovative medical devices focused on treating corneal edema. The company's flagship product, Hyper-CL, is a hyperosmotic contact lens designed to extract fluids from the cornea through osmosis, improving vision and relieving pain. Additionally, EyeYon Medical has developed DSPEK, an artificial endothelial layer intended to replace injured tissue that can cause corneal edema. Founded by Dr. Daphna Ofer, Dr. Arie Marcovich, and Nahum Ferera, the company operates within the Van Leer Technology Incubator.

V-Wave Ltd. is a medical technology company specializing in the development of percutaneous implantable therapeutic devices for patients with chronic heart failure. Established in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave aims to address the needs of patients who continue to experience severe symptoms or require hospitalization despite optimal medical treatment. The company's flagship product is the V-Wave Shunt, a biocompatible, inter-atrial unidirectional implant designed to alleviate symptoms related to chronic heart failure by regulating Left Atrial Pressure. This innovative device seeks to improve patients' quality of life by reducing hospitalizations, enhancing exercise capacity, and ultimately providing symptomatic relief. V-Wave's team comprises experienced engineers and medical scientists dedicated to advancing the field of cardiovascular devices.

Raziel Health, established in 2012 and headquartered in Rehovot, Israel, is a pharmaceutical company with a dual focus. Firstly, it develops injectable treatments, notably RZL-012, a novel synthetic small molecule designed to reduce fat tissue by causing fat cell death at the injection site. This drug is currently in clinical trials for various fat tissue indications and aesthetics. Secondly, Raziel Health offers a patient monitoring platform that uses artificial intelligence and machine learning to support remote patient care, enabling healthcare providers to improve patient outcomes across a wide range of conditions. The company's mission is to provide world-class, affordable healthcare in the comfort of patients' homes.

Pi Therapeutics is a discovery-stage biopharmaceutical company aiming to develop a novel cancer drug. The company is financed by a syndicate of Takeda Pharmaceutical Company through its venture group Takeda Ventures Inc., Johnson & Johnson Innovation – JJDC, OrbiMed Israel Partners, Pontifax, and the Israel Innovation Authority, and has operated since March 2015 in the FutuRx biotech accelerator in Ness Ziona, Israel. The company’s mission is to develop novel first-in-class drugs directed against the ubiquitin-proteasome system (UPS), mainly for treatment of cancer.

V-Wave Ltd. is a medical technology company specializing in the development of percutaneous implantable therapeutic devices for patients with chronic heart failure. Established in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave aims to address the needs of patients who continue to experience severe symptoms or require hospitalization despite optimal medical treatment. The company's flagship product is the V-Wave Shunt, a biocompatible, inter-atrial unidirectional implant designed to alleviate symptoms related to chronic heart failure by regulating Left Atrial Pressure. This innovative device seeks to improve patients' quality of life by reducing hospitalizations, enhancing exercise capacity, and ultimately providing symptomatic relief. V-Wave's team comprises experienced engineers and medical scientists dedicated to advancing the field of cardiovascular devices.

VBI Vaccines Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, with research facilities in Ottawa, Canada. It develops and sells vaccines for infectious diseases and immuno-oncology, with a focus on expanding protection in large, underserved markets. The company's enveloped virus-like particle (eVLP) platform enables the creation of vaccines that closely mimic target viruses, eliciting potent immune responses. VBI's commercial product, Sci-B-Vac, is a hepatitis B vaccine approved in Israel and 14 other countries, offering rapid onset of protection and high antibody levels. The company is also developing VBI-2601 for a functional cure of chronic hepatitis B, VBI-1901 for glioblastoma, and VBI-1501 for cytomegalovirus, among other candidates. VBI collaborates with pharmaceutical companies and research institutions, and its products are primarily distributed through direct sales to physicians and pharmacists.

VBI Vaccines Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, with research facilities in Ottawa, Canada. It develops and sells vaccines for infectious diseases and immuno-oncology, with a focus on expanding protection in large, underserved markets. The company's enveloped virus-like particle (eVLP) platform enables the creation of vaccines that closely mimic target viruses, eliciting potent immune responses. VBI's commercial product, Sci-B-Vac, is a hepatitis B vaccine approved in Israel and 14 other countries, offering rapid onset of protection and high antibody levels. The company is also developing VBI-2601 for a functional cure of chronic hepatitis B, VBI-1901 for glioblastoma, and VBI-1501 for cytomegalovirus, among other candidates. VBI collaborates with pharmaceutical companies and research institutions, and its products are primarily distributed through direct sales to physicians and pharmacists.

CathWorks Ltd. is a medical technology company that specializes in enhancing percutaneous coronary intervention (PCI) therapy decisions through its advanced computational science platform. Founded in 2013 and headquartered in Kfar-Saba, Israel, with an additional office in the United States, CathWorks aims to transform coronary angiography from subjective visual assessments into an objective decision-making tool. The company's flagship product, CathWorks FFRangio, is a non-invasive device that provides multi-vessel physiologic measurements, allowing physicians to optimize and confirm PCI therapy decisions during procedures. By leveraging functional flow reserve (FFR) data and automated algorithms, CathWorks enhances the use of coronary angiography data, promoting measurement-based medicine and improving operational efficiency in cath labs.

Eloxx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Waltham, Massachusetts, specializing in the development of novel drugs targeting rare and ultra-rare genetic diseases caused by nonsense mutations. Founded in 2013, the company is focused on discovering and commercializing ribonucleic acid modulating drug candidates. Its lead investigational product, ELX-02, is currently undergoing Phase 2 clinical trials aimed at treating cystic fibrosis and nephropathic cystinosis in patients with specific nonsense mutations. Eloxx utilizes its advanced technology platform to create oral small molecules that can induce ribosomal readthrough, thereby enabling the production of full-length functional proteins. The company is building a robust pipeline of therapeutic candidates designed to address various genetic disorders, including Duchenne Muscular Dystrophy and Tay-Sachs syndrome, by overcoming the limitations posed by premature stop codons.

Eloxx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Waltham, Massachusetts, specializing in the development of novel drugs targeting rare and ultra-rare genetic diseases caused by nonsense mutations. Founded in 2013, the company is focused on discovering and commercializing ribonucleic acid modulating drug candidates. Its lead investigational product, ELX-02, is currently undergoing Phase 2 clinical trials aimed at treating cystic fibrosis and nephropathic cystinosis in patients with specific nonsense mutations. Eloxx utilizes its advanced technology platform to create oral small molecules that can induce ribosomal readthrough, thereby enabling the production of full-length functional proteins. The company is building a robust pipeline of therapeutic candidates designed to address various genetic disorders, including Duchenne Muscular Dystrophy and Tay-Sachs syndrome, by overcoming the limitations posed by premature stop codons.

EyeYon Medical is an Israeli startup based in Jerusalem, developing innovative medical devices focused on treating corneal edema. The company's flagship product, Hyper-CL, is a hyperosmotic contact lens designed to extract fluids from the cornea through osmosis, improving vision and relieving pain. Additionally, EyeYon Medical has developed DSPEK, an artificial endothelial layer intended to replace injured tissue that can cause corneal edema. Founded by Dr. Daphna Ofer, Dr. Arie Marcovich, and Nahum Ferera, the company operates within the Van Leer Technology Incubator.

Nutrinia Ltd. is a neonatology company focused on developing pharmaceuticals to address rare gastrointestinal conditions in infants. Based in Ramat-Gan, Israel, the company has created oral formulations of insulin designed to enhance gut adaptation and rehabilitation in premature infants and children. Its key clinical programs include NTRA-2112, which aims to reduce enteral nutrition intolerance, promote growth velocity and weight gain, and decrease the length of stay in neonatal intensive care units. Another significant product, NTRA-9620, targets short bowel syndrome by improving bowel adaptation post-resection, facilitating enteral nutrition, and minimizing the reliance on parenteral nutrition. Founded in 2003, Nutrinia is committed to improving the health outcomes of vulnerable populations through innovative scientific solutions.

Entera Bio Ltd. is a clinical-stage biopharmaceutical company headquartered in Jerusalem, Israel, specializing in the development of orally delivered large molecule therapeutics, particularly peptides and therapeutic proteins. The company aims to address unmet medical needs in chronic conditions by offering a user-friendly oral drug delivery system. Its lead product candidates include EB612, an oral formulation of parathyroid hormone currently in Phase II clinical trials for hypoparathyroidism, and EB613, which is also in Phase II trials for osteoporosis and is being developed for non-union fractures. Entera Bio employs proprietary delivery technology that protects these large molecules in the gastrointestinal tract, enhancing their therapeutic potential. Founded in 2009, the company boasts a management team with over 50 years of combined experience in drug development, enabling efficient advancement of its innovative products.

OCON Healthcare, also known as OCON Medical Ltd., specializes in developing and manufacturing innovative women's health products centered around its proprietary Intra Uterine Ball (IUB) platform. Key offerings include the IUB Ballerine, a hormone-free, copper-based intrauterine contraceptive effective for five years, and the OCON SEAD, which is currently undergoing Phase II clinical studies for treating abnormal uterine bleeding. The IUB platform, constructed from a super-elastic alloy, serves as an effective carrier for various therapeutic substances targeting conditions such as heavy menstrual bleeding, fibroids, and infertility. The company distributes its contraceptive products primarily in Europe, South Africa, and Israel. Founded in 2011, OCON Healthcare operates from its headquarters in Modi'in-Maccabim-Re'ut, Israel, and maintains an additional office in Zürich, Switzerland.

V-Wave Ltd. is a medical technology company specializing in the development of percutaneous implantable therapeutic devices for patients with chronic heart failure. Established in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave aims to address the needs of patients who continue to experience severe symptoms or require hospitalization despite optimal medical treatment. The company's flagship product is the V-Wave Shunt, a biocompatible, inter-atrial unidirectional implant designed to alleviate symptoms related to chronic heart failure by regulating Left Atrial Pressure. This innovative device seeks to improve patients' quality of life by reducing hospitalizations, enhancing exercise capacity, and ultimately providing symptomatic relief. V-Wave's team comprises experienced engineers and medical scientists dedicated to advancing the field of cardiovascular devices.

EyeYon Medical is an Israeli startup based in Jerusalem, developing innovative medical devices focused on treating corneal edema. The company's flagship product, Hyper-CL, is a hyperosmotic contact lens designed to extract fluids from the cornea through osmosis, improving vision and relieving pain. Additionally, EyeYon Medical has developed DSPEK, an artificial endothelial layer intended to replace injured tissue that can cause corneal edema. Founded by Dr. Daphna Ofer, Dr. Arie Marcovich, and Nahum Ferera, the company operates within the Van Leer Technology Incubator.

OCON Healthcare, also known as OCON Medical Ltd., specializes in developing and manufacturing innovative women's health products centered around its proprietary Intra Uterine Ball (IUB) platform. Key offerings include the IUB Ballerine, a hormone-free, copper-based intrauterine contraceptive effective for five years, and the OCON SEAD, which is currently undergoing Phase II clinical studies for treating abnormal uterine bleeding. The IUB platform, constructed from a super-elastic alloy, serves as an effective carrier for various therapeutic substances targeting conditions such as heavy menstrual bleeding, fibroids, and infertility. The company distributes its contraceptive products primarily in Europe, South Africa, and Israel. Founded in 2011, OCON Healthcare operates from its headquarters in Modi'in-Maccabim-Re'ut, Israel, and maintains an additional office in Zürich, Switzerland.

Nutrinia Ltd. is a neonatology company focused on developing pharmaceuticals to address rare gastrointestinal conditions in infants. Based in Ramat-Gan, Israel, the company has created oral formulations of insulin designed to enhance gut adaptation and rehabilitation in premature infants and children. Its key clinical programs include NTRA-2112, which aims to reduce enteral nutrition intolerance, promote growth velocity and weight gain, and decrease the length of stay in neonatal intensive care units. Another significant product, NTRA-9620, targets short bowel syndrome by improving bowel adaptation post-resection, facilitating enteral nutrition, and minimizing the reliance on parenteral nutrition. Founded in 2003, Nutrinia is committed to improving the health outcomes of vulnerable populations through innovative scientific solutions.

Check-Cap Ltd. is a clinical-stage medical diagnostics company based in Isfiya, Israel, specializing in the development of innovative solutions for colorectal cancer screening. The company's flagship product, the C-Scan system, is a capsule-based technology that utilizes low-dose X-rays to detect colonic polyps and colorectal cancers without the need for bowel preparation or invasive procedures. The C-Scan system consists of three components: the C-Scan Cap, an ingestible capsule that collects and transmits imaging data; the C-Scan Track, a biocompatible device worn by the patient to track the capsule's movement and record data; and C-Scan View, software designed to process and visualize the captured clinical data. This preparation-free approach is intended to provide accuracy comparable to traditional colonoscopy, with the capsule passing naturally through the gastrointestinal tract. Check-Cap aims to bring its technology to markets in the United States, Europe, Israel, and Japan.

HeadSense Medical Ltd. is an early-stage company based in Netanya, Israel, focused on developing non-invasive diagnostic devices for brain health. Founded in 2011, the company has created a validated intracranial pressure (ICP) monitor that has received CE Mark approval. This innovative device is utilized in various medical fields, including neurosurgery, neurology, emergency medicine, and critical care, providing physicians with essential tools to diagnose and monitor crucial clinical parameters. In addition to its ICP monitor, HeadSense is actively working on expanding its platform to include applications for diagnosing cerebral vasospasm, assessing concussion severity, and quantifying traumatic brain injury (TBI).

V-Wave Ltd. is a medical technology company specializing in the development of percutaneous implantable therapeutic devices for patients with chronic heart failure. Established in 2009 and headquartered in Caesarea, Israel, with additional offices in the United States, V-Wave aims to address the needs of patients who continue to experience severe symptoms or require hospitalization despite optimal medical treatment. The company's flagship product is the V-Wave Shunt, a biocompatible, inter-atrial unidirectional implant designed to alleviate symptoms related to chronic heart failure by regulating Left Atrial Pressure. This innovative device seeks to improve patients' quality of life by reducing hospitalizations, enhancing exercise capacity, and ultimately providing symptomatic relief. V-Wave's team comprises experienced engineers and medical scientists dedicated to advancing the field of cardiovascular devices.

OCON Healthcare, also known as OCON Medical Ltd., specializes in developing and manufacturing innovative women's health products centered around its proprietary Intra Uterine Ball (IUB) platform. Key offerings include the IUB Ballerine, a hormone-free, copper-based intrauterine contraceptive effective for five years, and the OCON SEAD, which is currently undergoing Phase II clinical studies for treating abnormal uterine bleeding. The IUB platform, constructed from a super-elastic alloy, serves as an effective carrier for various therapeutic substances targeting conditions such as heavy menstrual bleeding, fibroids, and infertility. The company distributes its contraceptive products primarily in Europe, South Africa, and Israel. Founded in 2011, OCON Healthcare operates from its headquarters in Modi'in-Maccabim-Re'ut, Israel, and maintains an additional office in Zürich, Switzerland.

cCAM Biotherapeutics Ltd. is a clinical-stage biotechnology company based in Misgav, Israel, focused on the discovery and development of innovative immunotherapies for cancer treatment. The company is developing CM-10, an immunomodulatory antibody designed to enhance the immune system's ability to target and attack tumors by binding to CEACAM1, a protein that cancer cells exploit to evade immune responses. cCAM's lead therapeutic candidate, CM-24, is a humanized anti-CEACAM1 monoclonal antibody aimed at treating advanced and recurrent cancers, including melanoma, non-small-cell lung cancer, bladder, gastric, colorectal, and ovarian cancers. Established in 2010, cCAM Biotherapeutics aims to provide effective treatment options for patients facing various malignancies.

Avraham Pharmaceuticals Ltd. is a privately held pharmaceutical company based in Yavne, Israel, founded in 2010. The company focuses on the development of innovative products for the treatment and prevention of neurodegenerative disorders. Its lead product candidate, Ladostigil, is designed for mild cognitive impairment and employs a combination of neuroprotective mechanisms, including the reduction of oxidative stress, inhibition of pro-inflammatory cytokines, and modulation of microglial activation. Avraham Pharmaceuticals has raised funding to support clinical trials, including a European Phase II proof-of-concept efficacy trial for Alzheimer's disease, aimed at validating the effectiveness of Ladostigil.

Aposense Ltd. is a biopharmaceutical company based in Petah Tikva, Israel, specializing in the development of innovative drugs that leverage the unique structural and electrical properties of biological membranes. Founded in 1996, Aposense focuses on creating molecular nano-motors capable of harnessing energy from intra-membrane electric fields to facilitate the delivery of genetic drugs, such as siRNA, into cells. The company has developed a platform technology known as Apo-Si, which supports targeted therapy and real-time clinical imaging of disease activity, particularly in oncology, cardiology, and neurology. Aposense is also advancing its proprietary drug candidate, ATT-11T, a conjugate designed to treat solid tumors by combining a molecular nano-motor with SN-38, the active component of irinotecan. With its commitment to transforming apoptosis targeting into practical applications, Aposense is at the forefront of integrating advanced therapeutic strategies into personalized patient care.

Applied Immune Technologies Ltd. is engaged in the development of therapeutic molecules aimed at treating cancer, viral, and autoimmune diseases. The company specializes in T-Cell Receptor-Like (TCRL) antibodies that target intracellular-derived peptides for both therapeutic and diagnostic purposes. These antibodies have applications in pathology, vaccine design, validation, and monitoring, as well as in the analysis of antigen presentation in various diseases. Established in 2006 and based in Haifa, Israel, Applied Immune Technologies was previously known as BioMimic Pharma. The company operates as a subsidiary of Adicet Bio, Inc.

ProtAb develops therapeutic agents that modulate cytokine regulation, tipping the balance toward anti-inflammatory signaling pathways in the treatment of autoimmune and inflammatory diseases. Its first product, Prozumab, is a monoclonal antibody with a novel mechanism of action. It is currently in late-stage preclinical development for the treatment of inflammatory bowel disease or IBD, ulcerative colitis or UC, and rheumatoid arthritis or RA. It operates as a subsidiary of Hadasit Bio-Holdings. HBL is a publicly traded subsidiary of Hadasit, the technology transfer company of the Hadassah University Hospital in Jerusalem in Israel.

Aposense Ltd. is a biopharmaceutical company based in Petah Tikva, Israel, specializing in the development of innovative drugs that leverage the unique structural and electrical properties of biological membranes. Founded in 1996, Aposense focuses on creating molecular nano-motors capable of harnessing energy from intra-membrane electric fields to facilitate the delivery of genetic drugs, such as siRNA, into cells. The company has developed a platform technology known as Apo-Si, which supports targeted therapy and real-time clinical imaging of disease activity, particularly in oncology, cardiology, and neurology. Aposense is also advancing its proprietary drug candidate, ATT-11T, a conjugate designed to treat solid tumors by combining a molecular nano-motor with SN-38, the active component of irinotecan. With its commitment to transforming apoptosis targeting into practical applications, Aposense is at the forefront of integrating advanced therapeutic strategies into personalized patient care.

CollPlant Biotechnologies Ltd. is a regenerative medicine company specializing in the 3D bioprinting of tissues and organs, as well as medical aesthetic products. Headquartered in Rehovot, Israel, the company utilizes its proprietary plant-based genetic engineering technology to produce recombinant human collagen (rhCollagen). CollPlant's product offerings include BioInks for tissue and organ bioprinting, a dermal filler for wrinkle treatment, 3D bioprinted breast implants, and the Vergenix line, which features a soft tissue repair matrix for tendinopathy and an advanced wound care product designed for various chronic wounds. Founded in 2004, CollPlant aims to address diverse needs in the fields of tissue repair and aesthetics across the United States, Canada, and Europe.

CollPlant Biotechnologies Ltd. is a regenerative medicine company specializing in the 3D bioprinting of tissues and organs, as well as medical aesthetic products. Headquartered in Rehovot, Israel, the company utilizes its proprietary plant-based genetic engineering technology to produce recombinant human collagen (rhCollagen). CollPlant's product offerings include BioInks for tissue and organ bioprinting, a dermal filler for wrinkle treatment, 3D bioprinted breast implants, and the Vergenix line, which features a soft tissue repair matrix for tendinopathy and an advanced wound care product designed for various chronic wounds. Founded in 2004, CollPlant aims to address diverse needs in the fields of tissue repair and aesthetics across the United States, Canada, and Europe.

CollPlant Biotechnologies Ltd. is a regenerative medicine company specializing in the 3D bioprinting of tissues and organs, as well as medical aesthetic products. Headquartered in Rehovot, Israel, the company utilizes its proprietary plant-based genetic engineering technology to produce recombinant human collagen (rhCollagen). CollPlant's product offerings include BioInks for tissue and organ bioprinting, a dermal filler for wrinkle treatment, 3D bioprinted breast implants, and the Vergenix line, which features a soft tissue repair matrix for tendinopathy and an advanced wound care product designed for various chronic wounds. Founded in 2004, CollPlant aims to address diverse needs in the fields of tissue repair and aesthetics across the United States, Canada, and Europe.

CollPlant Biotechnologies Ltd. is a regenerative medicine company specializing in the 3D bioprinting of tissues and organs, as well as medical aesthetic products. Headquartered in Rehovot, Israel, the company utilizes its proprietary plant-based genetic engineering technology to produce recombinant human collagen (rhCollagen). CollPlant's product offerings include BioInks for tissue and organ bioprinting, a dermal filler for wrinkle treatment, 3D bioprinted breast implants, and the Vergenix line, which features a soft tissue repair matrix for tendinopathy and an advanced wound care product designed for various chronic wounds. Founded in 2004, CollPlant aims to address diverse needs in the fields of tissue repair and aesthetics across the United States, Canada, and Europe.