Polaris Partners

Auron Therapeutics is a biotechnology company focused on cancer therapy development that seeks to change the paradigm from tumor cell killing to differentiation therapy, aiming to transform malignant cells into normal functioning cells by reactivating endogenous cellular programs. The company uses platforms that integrate large-omic datasets and miniaturized high-throughput flow cytometry to rapidly identify and validate multiple targets and drugs in primary human patient samples. This approach is designed to advance therapeutic candidates for cancer across areas of unmet medical need and to support the development of transformative medicines. Auron Therapeutics was founded in 2018 and is based in Wellesley, Massachusetts.

Leyden Labs develops a Mucosal Protection Platform to protect against respiratory viruses, including influenza and coronaviruses. The company offers a portfolio of broad protective nasal sprays designed to reduce the risk of infection and limit transmission, aiming to improve public health through innovative protection methods. Its team combines biotechnology veterans with new talent to advance solutions that address common viral threats at the mucosal surface.

Founded in 2019, Noema Pharma is a biotechnology company based in Basel, Switzerland. It specializes in developing innovative therapies for orphan neurological disorders characterized by imbalanced neuronal networks, aiming to improve patient outcomes and quality of life.

TRexBio is a biotechnology company that leverages cutting-edge computational biology tools, a focus on human tissue, and expertise in immunobiology to develop therapeutics for cancer and inflammatory diseases. Its 'deep biology' discovery engine maps human tissue Treg behavior to disease processes, identifying and characterizing novel targets for therapeutic intervention. The platform supports the development of a portfolio of therapies that modulate the immune system to restore tissue immune homeostasis.

Vico Therapeutics B.V. is a biotechnology company based in Leiden, the Netherlands, founded in 2019. The company specializes in the development of RNA modulating therapies aimed at treating rare neurological disorders. Vico Therapeutics focuses on conditions such as spinocerebellar ataxias, Huntington’s disease, and Rett syndrome, which encompass a range of hereditary and neurodevelopmental disorders. By discovering and developing innovative therapies, the company aims to address significant unmet medical needs in the central nervous system, providing new treatment options for patients and healthcare professionals.

Livara Health specializes in non-invasive, personalized treatment for musculoskeletal conditions. Its platform offers a data-driven six-week program for back pain relief, customized based on patient assessment, along with coaching support.

Capstan Therapeutics specializes in developing innovative therapeutics using precision cell engineering for various diseases with unmet clinical needs.

Vico Therapeutics B.V. is a biotechnology company based in Leiden, the Netherlands, founded in 2019. The company specializes in the development of RNA modulating therapies aimed at treating rare neurological disorders. Vico Therapeutics focuses on conditions such as spinocerebellar ataxias, Huntington’s disease, and Rett syndrome, which encompass a range of hereditary and neurodevelopmental disorders. By discovering and developing innovative therapies, the company aims to address significant unmet medical needs in the central nervous system, providing new treatment options for patients and healthcare professionals.

Seismic Therapeutic is a biotechnology company focused on advancing immunology drug development through the integration of machine learning in the biologics discovery process. Utilizing its proprietary IMPACT™ platform, Seismic Therapeutic addresses critical challenges in the development of biologics by combining machine learning with structural biology, protein engineering, and translational immunology. This innovative approach aims to create optimized therapies for patients more efficiently. The company is developing a pipeline of biologics specifically targeting adaptive immune system dysregulation to treat various autoimmune diseases.

Candesant Biomedical, Incorporated is a medical device company focused on developing innovative solutions for excessive sweating and hyperhidrosis. Founded in 2015 and based in San Francisco, California, the company offers a proprietary device known as CDX-101, which utilizes water-activated technology to target and inactivate active sweat glands without causing discomfort to patients. The technology operates on the principle that alkali metals generate energy upon contact with water, allowing for precise energy delivery to the specific areas where sweat glands are most active. This approach not only aims to reduce excessive sweating but also helps inhibit bacterial growth associated with hyperhidrosis, providing a significant improvement in the quality of life for affected individuals.

QurAlis Corporation is a Cambridge, Massachusetts-based clinical-stage biotechnology company developing precision therapeutics for amyotrophic lateral sclerosis and other neurodegenerative diseases. It focuses on drugs that directly target disease-causing genetic alterations using proprietary platforms and biomarkers to identify and treat patients with specific genetic mutations, aiming to halt disease progression and improve outcomes.

Founded in 2019, Noema Pharma is a biotechnology company based in Basel, Switzerland. It specializes in developing innovative therapies for orphan neurological disorders characterized by imbalanced neuronal networks, aiming to improve patient outcomes and quality of life.

August Bioservices, LLC is a contract development and manufacturing organization (CDMO) based in Nashville, Tennessee, with an additional office in Celina, Tennessee. Established in 2017, the company specializes in offering a wide range of services for drug discovery, pharmaceutical development, and clinical manufacturing. Its research services encompass target validation, functional characterization, assay development, drug discovery, protein engineering, and both in vitro and in vivo testing. In the pharmaceutical development arena, August Bioservices provides formulation, process design, optimization, scale-up, and analytical method development. The company's clinical manufacturing capabilities include clinical trial supply, cGMP non-sterile and bulk manufacturing, aseptic fill and finish, and quality control. Additionally, it offers various testing services, such as pregnancy testing and viral disease testing, to clients in the pharmaceutical and biotechnology sectors. August Bioservices was previously known as PMI BioPharma Solutions until its name change in July 2020.

Folx Health is a Boston-based telehealth platform founded in 2020, specializing in digital healthcare services tailored for the LGBTQIA+ community. It offers access to queer and trans clinicians, focusing on gender-affirming hormone therapy, sexual health, and family creation services.

Neumora Therapeutics is a clinical-stage biotechnology company focused on developing precision medicines for brain diseases by combining data science with neuroscience. Founded to address the global brain disease crisis, Neumora takes an innovative approach to treatment development. The company has established a robust therapeutic pipeline that includes seven clinical and preclinical neuroscience programs targeting novel mechanisms of action for various underserved neuropsychiatric and neurodegenerative disorders. Neumora plans to advance its pipeline further by initiating multiple clinical trials across its programs in the upcoming 12 to 18 months.

CAMP4 Therapeutics Corporation is a bioinformatics company founded in 2015 and based in Cambridge, Massachusetts. The company specializes in gene regulation circuitry, focusing on the fundamental causes of diseases by manipulating gene expression. Utilizing its proprietary 4-D gene circuitry platform, CAMP4 codifies the activation of approximately 24,000 human genes into a discrete set of combinatorial rules based on existing cellular signaling pathways. This innovative approach allows CAMP4 to effectively control gene production, thereby accelerating the development of new therapies. By employing this technology, the company aims to streamline the drug development process, significantly reducing both the time and risks associated with bringing new medicines to patients.

Ankyra is a biotech company focused on developing anchored immunotherapy to enhance cancer treatment. The company's innovative approach addresses the challenges associated with traditional cytokine therapeutics, which often face limitations due to widespread immune activation and toxicity when administered systemically. Ankyra utilizes its Anchored Immunotherapy Platform to create ANK-101, a stable complex that combines a modified IL-12 cytokine with an FDA-approved adjuvant, aluminum hydroxide, which helps to retain the cytokine's potent activity at the tumor site. This localized delivery results in targeted inflammation that activates an anti-tumor immune response while minimizing adverse effects. Ankyra aims to optimize the efficacy and safety of its therapies, ultimately improving treatment outcomes for cancer patients.

Cardurion Pharmaceuticals, LLC, established in 2017 and headquartered in Boston, Massachusetts, is a biotechnology company dedicated to developing innovative therapies for heart failure and other cardiovascular diseases. The company is advancing clinical programs that target PDE9 and CaMKII inhibition, utilizing its expertise in cardiovascular signaling pathways to address significant unmet patient needs.

Jnana Therapeutics Inc. is a biotechnology company based in Boston, Massachusetts, founded in 2016. It specializes in drug discovery, particularly focusing on solute carrier (SLC) transporters, which are vital for understanding various disease pathways. The company’s efforts are directed towards immunometabolism, lysosomal function, and mucosal defense, with applications in immuno-oncology, inflammatory disorders, and neurological diseases. Utilizing its proprietary RAPID platform, Jnana accelerates the identification of therapeutic targets and the development of small molecule therapies. By leveraging advanced chemoproteomics techniques, the company aims to enhance the efficiency of drug discovery and address significant unmet medical needs in patient care.

Founded in 2016, ByHeart is a New York-based company dedicated to producing evolved infant nutrition products. It translates leading scientific research into innovative foods and formulas that prioritize immune, microbiome, cognitive, and digestive health.

Wellthy, Inc. is a family care concierge service based in New York, established in 2014. The company specializes in assisting individuals and families managing complex care situations, particularly those involving chronic illnesses, aging-related issues, or disabilities. Wellthy connects families with dedicated Care Coordinators who help navigate the logistical and administrative challenges of caregiving. This includes organizing appointments, managing contacts, and storing essential documents. The service is designed to support families dealing with a range of health conditions, such as dementia, diabetes, heart disease, and cancer, as well as those requiring assistance with childcare and special needs. Through its platform, Wellthy aims to alleviate the burden of care management, allowing families to focus on their loved ones’ well-being.

Founded in 2019 and based in Boston, Cohere Health is a healthcare technology company dedicated to enhancing efficiency and effectiveness within the healthcare system. It achieves this by leveraging technology to simplify processes, improve communication among stakeholders, and ultimately optimize patient outcomes.

Amunix Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to discovering and developing innovative protein and peptide therapeutics aimed at treating cancer. The company employs several proprietary platforms, including XTEN for extending drug half-life, XPAT for analyzing protease activity in the tumor microenvironment, and ProTIA, which focuses on immuno-oncology therapeutics. Amunix's product pipeline includes prodrugs and transformative T-cell engagers designed to activate the immune system against solid tumors. The company collaborates with various academic, biotechnology, and pharmaceutical sectors, maintaining strategic partnerships with organizations such as Janssen and Biogen-Idec. Founded in 2006 and headquartered in Mountain View, California, Amunix strives to deliver breakthroughs that can harness the immune system to combat cancer more effectively.

Armorblox, Inc. is a cybersecurity company founded in 2017 and based in Cupertino, California. It specializes in developing data security solutions that focus on protecting the human layer within organizations. Utilizing advanced machine learning and artificial intelligence techniques, Armorblox addresses identity-based attacks and data loss, providing comprehensive security for its clients. The company's innovative approach aims to enhance overall data protection and safeguard sensitive information in an increasingly complex digital landscape.

Invivyd is a commercial-stage biopharmaceutical company dedicated to developing and commercializing antibody-based therapies aimed at protecting individuals from serious viral infectious diseases, particularly those with pandemic potential. The company focuses on innovative solutions that surpass the natural limits of immunity, starting with its lead product candidates for SARS-CoV-2. Notable among these candidates are ADG20, designed for the treatment and prevention of COVID-19, and VYD222, a monoclonal antibody optimized for enhanced potency and durability of protection. Invivyd's mission centers on delivering effective, long-lasting therapies to safeguard vulnerable populations from the severe repercussions of ongoing viral threats.

Sonrai Security provides a comprehensive enterprise identity and data governance platform for AWS, Azure, Google Cloud, and Kubernetes. Its flagship product, Dig, uses advanced graph technology to identify and monitor relationships between identities and data within public clouds. The platform automates workflows, remediation, and prevention capabilities across cloud and security teams, ensuring end-to-end security.

Founded in 2018 and headquartered in Boston, Massachusetts, Dewpoint Therapeutics is a biotechnology company dedicated to researching biomolecular condensates and cellular function. The company aims to develop innovative treatments for various diseases such as cancer, neurodegenerative disorders, immunology, cardiovascular conditions, women's health, and virology.

Podimetrics, Inc. is a healthcare technology company specializing in the prevention of diabetic foot ulcers, a significant complication of diabetes. Founded in 2011 and based in Somerville, Massachusetts, Podimetrics has developed the SmartMat, a wireless in-home monitoring system that enables patients to scan their foot temperature for just 20 seconds each day. This data is automatically transmitted to a dedicated care management team, which monitors for any concerning findings. By integrating advanced technology with effective clinical support, Podimetrics enhances patient engagement and helps clinicians achieve better health outcomes, ultimately saving limbs, lives, and healthcare costs. The company was founded by a physician and engineers from prestigious institutions, reflecting its commitment to innovation in diabetes care management.

2 out of 3 men will start to lose their hair by the age of 35 - but the earlier you take action, the more hair you keep. Keeps is a full-service healthcare company focused exclusively on helping men keep their hair. From expert diagnosis to affordable treatment, patient support to education, Keeps provides a regimen specific to each customer's condition through a seamless digital experience, allowing men to manage hair loss from start to finish. Keeps’ licensed physicians review each customer's information in order to identify and prescribe a unique treatment plan of FDA-approved products, and we sell them at half the price customers would pay at their local pharmacy. With Keeps, customers receive exactly what they need, and nothing they don’t. Keeps is the first brand from Thirty Madison, which is rebuilding the healthcare experience for the modern consumer.

Thirty Madison is a digital health company specializing in personalized treatments for chronic conditions. It operates platforms like Keeps (hair loss), Cove (migraines), Picnic (allergies), Facet (skin conditions), and Nurx (sexual health). Founded in 2016, it aims to empower individuals with accessible, effective care tailored to their specific needs.

Glympse Bio, Inc. is a biotechnology company based in Cambridge, Massachusetts, that specializes in developing modular nanoparticle sensors for noninvasive diagnostics. Founded in 2015, the company focuses on creating diagnostic solutions for various diseases, including fibrosis, cancer, immunology, and infectious diseases. Utilizing a unique platform technology originally developed at MIT, Glympse Bio employs precisely engineered diagnostic agents that interrogate the body to detect specific disease states and transmit this information to urine for analysis. This innovative approach facilitates predictive monitoring and enhances the ability of physicians to assess treatment responses accurately. The company aims to transform disease monitoring and improve patient outcomes through its Glympse Inside product engine, which supports comprehensive, pan-disease diagnostics.

Pandion Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Watertown, Massachusetts, focused on developing innovative therapeutics for patients with autoimmune diseases. The company’s lead product candidate, PT101, is an engineered interleukin-2 variant currently undergoing Phase 1a clinical trials for various autoimmune and inflammatory conditions, including moderate-to-severe ulcerative colitis and systemic lupus erythematosus. In addition to PT101, Pandion's pipeline includes PT627, a systemic PD-1 agonist in preclinical studies, and two bifunctional molecules, PT001 and PT002, designed to provide tissue-selective immunomodulation by targeting specific adhesion molecules in the gastrointestinal tract. Pandion employs a network-based approach to immune system conceptualization through its TALON drug design platform and collaborates with Astellas Pharma to develop locally acting immunomodulators for pancreatic autoimmune diseases. The company aims to create a new generation of therapeutics that offer enhanced efficacy and safety for the treatment of autoimmune and inflammatory diseases.

Podimetrics, Inc. is a healthcare technology company specializing in the prevention of diabetic foot ulcers, a significant complication of diabetes. Founded in 2011 and based in Somerville, Massachusetts, Podimetrics has developed the SmartMat, a wireless in-home monitoring system that enables patients to scan their foot temperature for just 20 seconds each day. This data is automatically transmitted to a dedicated care management team, which monitors for any concerning findings. By integrating advanced technology with effective clinical support, Podimetrics enhances patient engagement and helps clinicians achieve better health outcomes, ultimately saving limbs, lives, and healthcare costs. The company was founded by a physician and engineers from prestigious institutions, reflecting its commitment to innovation in diabetes care management.

Faraday Pharmaceuticals, established in 2014 and headquartered in Seattle, Washington, is an early-stage biopharmaceutical company dedicated to developing innovative therapies targeting ischemia-reperfusion injury. The company's proprietary pipeline comprises liquid formulations of reduced nonmetal gaseous elements, licensed from the lab of Dr. Mark Roth at Fred Hutchinson Cancer Center. Faraday Pharmaceuticals aims to create elemental reducing agents that can improve patient outcomes by simplifying the treatment of critical care illnesses like reperfusion injury following ST elevation myocardial infarction.

Proof operates as a technology company specializing in secure digital transactions. It provides an identity-assured transaction management platform that verifies the identities of individuals engaging in online business dealings. By confirming identities and securing transactions, Proof helps protect both businesses and their customers from fraudulent activities, fostering trust in digital environments.

Freenome, Inc. is an artificial intelligence genomics biotech company based in South San Francisco, California, founded in 2014. The company focuses on developing accurate, accessible, and non-invasive blood tests for the early detection of cancer and treatment selection. Utilizing a proprietary multi-omics platform, Freenome employs advanced algorithms to analyze cell-free genomic data, which aids in identifying early-stage cancers and other diseases. This innovative approach aims to transform disease management by enabling timely interventions and proactive treatment strategies. In addition to its diagnostic solutions, Freenome also offers clinical research services to further advance cancer detection and management.

Founded in Vermont in 2012, Caledonia Spirits is a craft distillery dedicated to supporting local agriculture. It produces gin and vodka using locally sourced ingredients like grains and honey, aiming to add value to the work of Vermont farmers while honoring traditional spirits-making techniques.

Blackthorn Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in South San Francisco, California, founded in 2013. The company focuses on developing precision medicine for neurobehavioral disorders, utilizing advances in computational and clinical neuroscience. By leveraging its proprietary computational platform, Blackthorn aims to address historical challenges in drug discovery by targeting dysfunctional brain circuits. This approach enables the identification of novel drug candidates and biologically-based patient subgroups that are most likely to respond to specific treatments. Through its innovative strategies, Blackthorn seeks to enhance the precision of therapeutic interventions for disorders of the central nervous system, ultimately improving patient outcomes.

Lyndra Therapeutics develops ultra‑long‑acting oral medicines that release drugs over periods of up to a month while temporarily residing in the stomach. The company focuses on sustained, steady‑state delivery for conditions such as Alzheimer’s disease, cardiovascular and metabolic disorders, psychiatric and opioid use disorders, immunology, HIV, malaria vector control, and oral contraceptives. Founded in 2015 and headquartered in Watertown, Massachusetts, Lyndra’s platform aims to improve medication adherence and reduce healthcare costs by enabling once‑weekly or monthly dosing of approved drugs and novel therapeutics.

KenSci Inc. is a healthcare technology company that specializes in developing a machine learning platform aimed at improving risk prediction for healthcare providers and payers. Founded in 2015 and headquartered in Seattle, Washington, with additional offices in Hyderabad and Singapore, KenSci's platform integrates and analyzes data from various sources, including clinical records, claims, and patient-generated information. This enables healthcare organizations to identify clinical, financial, and operational risks, allowing for earlier interventions that can save costs and improve patient outcomes. The platform offers a library of pre-built models and modular solutions, facilitating seamless integration into existing workflows to enhance hospital operations and care coordination. By leveraging Explainable AI, KenSci ensures that its risk-based predictions are both efficient and accountable, ultimately supporting the delivery of better healthcare.

Kallyope Inc. is a biotechnology company based in New York City that focuses on understanding the gut-brain axis to develop innovative therapeutics and consumer products aimed at enhancing human health. Established in 2014, Kallyope employs advanced technologies, including sequencing, computational biology, neural imaging, and human genetics, to explore gut-brain biology. The company aims to address significant unmet medical needs, such as diabetes, obesity, gut disorders, inflammatory diseases, migraines, and allergies, by creating effective and user-friendly oral agents. Kallyope's team consists of experienced scientists from leading institutions, working alongside a skilled team with a strong track record in drug discovery and development. Through its research, Kallyope seeks to deliver transformative solutions that improve overall health outcomes.

Morphic Therapeutic is a biotechnology company focused on developing oral integrin therapies to treat serious chronic diseases such as autoimmune disorders, cardiovascular conditions, metabolic diseases, fibrosis, and cancer.

Simon Data develops a customer data platform designed to enhance campaign performance via precise segmentation and personalization. Its platform identifies purchase intent, predicts churn, estimates customer lifetime value, and enables brands to deliver personalized experiences across channels.

Gossamer Bio is a clinical-stage biopharmaceutical company based in San Diego that specializes in the discovery, development, and commercialization of innovative therapeutic products targeting significant unmet medical needs. Founded by former executives from Receptos, the company focuses on areas such as immunology, inflammation, fibrosis, and oncology. Its pipeline includes several promising candidates: Seralutinib, aimed at addressing pulmonary arterial hypertension; GB004, for inflammatory bowel disease; GB1275, targeting various oncology indications; and GB001, designed for moderate-to-severe eosinophilic asthma. Gossamer Bio's strategy involves leveraging a rich in-licensing environment to enhance its therapeutic offerings, supported by a team recognized for their successful track record in drug development.

Pointy is a company founded in 2014 that assists retail stores in establishing an online presence for their products. It develops a product tracking device that integrates with point-of-sale systems to automatically generate online product listings. When items are scanned through this system, they are instantly displayed on a product page, allowing local stores to showcase their inventory to potential customers searching online. This service enhances visibility for retailers and facilitates easier access for consumers seeking local products.

Ajax Health is a venture capital firm dedicated to the healthcare sector. It invests across stages in medical devices, medtech, healthcare services, digital health, biotechnology and healthcare information technology, aiming to advance innovative solutions that address major healthcare challenges. Founded in 2017, the firm is headquartered in Menlo Park, California, with an additional office in New York City. Ajax Health seeks to accelerate medical innovation through capital and capabilities to support portfolio companies.

OM1 is a digital health company that provides an outcome management platform for healthcare organizations to measure, forecast, and compare patient outcomes. Its platform aggregates and analyzes clinical and patient-reported data to meet outcomes requirements in value-based care programs, CMS bundles, and private arrangements. The solution uses predictive and prescriptive analytics to identify risks, cost drivers, and opportunities to improve clinical and financial performance across the care continuum. By delivering AI-driven insights, OM1 helps hospitals and health systems demonstrate outcomes to stakeholders, support benchmarking and decision-making, and drive more precise care management. The company also maintains specialized registries for collaborations, including systemic lupus erythematosus, to support research and performance improvement. Through gathering and enriching diverse clinical data, OM1 aims to establish a higher standard for health outcomes information and enable more informed, value-based care.

Nomad Health, Inc. is an online marketplace that connects clinicians with freelance and permanent clinical job opportunities in the United States. Founded in 2015 and based in New York, the company provides a platform where doctors and nurses can search for employment based on various criteria such as location, pay rate, and medical specialty. Nomad Health aims to streamline the healthcare staffing process by replacing traditional methods with a modern, efficient technology platform. The service not only simplifies job searches but also manages digital resumes and credentials, facilitating communication between clinicians and healthcare facilities. This innovative approach addresses the complexities of healthcare staffing, enhancing the experience for both job seekers and providers.

Kallyope Inc. is a biotechnology company based in New York City that focuses on understanding the gut-brain axis to develop innovative therapeutics and consumer products aimed at enhancing human health. Established in 2014, Kallyope employs advanced technologies, including sequencing, computational biology, neural imaging, and human genetics, to explore gut-brain biology. The company aims to address significant unmet medical needs, such as diabetes, obesity, gut disorders, inflammatory diseases, migraines, and allergies, by creating effective and user-friendly oral agents. Kallyope's team consists of experienced scientists from leading institutions, working alongside a skilled team with a strong track record in drug discovery and development. Through its research, Kallyope seeks to deliver transformative solutions that improve overall health outcomes.

TARIS Biomedical, Inc. is a therapeutically focused urology company based in Lexington, Massachusetts, established in 2008. The company specializes in developing innovative treatments for challenging bladder diseases, including bladder cancer and overactive bladder. TARIS Biomedical's proprietary system is designed to continuously release medications directly into the bladder over extended periods, ranging from weeks to months. This technology is administered through minimally invasive, in-office procedures, allowing for customized drug delivery that aligns with the specific needs of various bladder conditions. As of December 2019, TARIS Biomedical operates as a subsidiary of Janssen Research & Development, LLC.

Metacrine, Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, established in 2014. It specializes in the discovery and development of innovative therapies aimed at treating liver and gastrointestinal diseases. The company is advancing a pipeline of drug candidates, with a primary focus on the farnesoid X receptor (FXR), a key target in managing various liver and GI disorders. Its lead candidates, MET409 and MET642, are currently in clinical trials to evaluate their efficacy in treating non-alcoholic steatohepatitis. Additionally, Metacrine collaborates with Novo Nordisk A/S to explore further research opportunities related to fibroblast growth factor 1. The company is committed to developing best-in-class therapies to improve patient outcomes in these challenging medical areas.

KSQ Therapeutics, Inc., founded in 2015 and based in Cambridge, Massachusetts, specializes in precision functional genomics to discover innovative drug therapies. The company employs a novel approach to research and development that emphasizes de-risking prior to the creation of therapeutic candidates. Utilizing its proprietary CRISPRomics™ drug discovery engine, KSQ Therapeutics has mapped the functions of human genes across various diseases, enhancing its understanding of disease biology. This comprehensive insight enables the identification and validation of high-confidence, patient-specific drug targets. As a result, the company is focused on developing medicines that have significant potential to improve patient outcomes and has established a pipeline of preclinical discovery programs.

FloQast is a software company specializing in financial close management. It offers tools to streamline the month-end close process, improve collaboration among accounting teams, and enhance accuracy in financial reporting. FloQast's platform provides features such as task management, documentation, reconciliation, and reporting, integrating with various accounting systems like QuickBooks, NetSuite, and SAP.

Lob designs and develops APIs for businesses to automate direct mail services. It offers postcards, letters, checks, address verification, and campaign tracking. With over 7,000 customers ranging from Fortune 500 companies to individual developers, Lob improves data quality and reduces mail processing time.

Twistlock Inc. is a provider of comprehensive security solutions for cloud-native applications, focusing on Docker container security for DevOps environments. Founded in 2015, the company offers a suite of products designed to protect applications throughout their development lifecycle and into production. Its flagship product, Twistlock, enables developers and security teams to safeguard container-based applications with features such as vulnerability management, compliance, access control, and runtime defense. Twistlock's Trust component scans images and registries to identify vulnerabilities and configuration errors, while Twistlock Runtime delivers real-time threat protection and policy enforcement. The company is trusted by a significant portion of the Fortune 100 and is headquartered in Portland, Oregon, with additional offices in New York City, Baton Rouge, London, and Herzliya, Israel. As of July 2019, Twistlock operates as a subsidiary of Palo Alto Networks, Inc.

Drizly is an online alcohol marketplace and liquor retail platform that enables on-demand delivery and shipping of beer, wine and spirits. It partners with retailers to bring their inventory online across 235 markets, offering a broad selection to consumers of legal drinking age and a transparent, personalized shopping experience. Founded in 2012 and headquartered in Boston, Massachusetts, Drizly helps retailers reach new customers and gain market and customer insights, supporting growth in sales. The platform also supports ordering of beverages along with mixers and garnishes, enabling customers to order without visiting a store.

Qstream, Inc. is a software company that specializes in developing a mobile sales acceleration platform designed to enhance job proficiency and influence behavior within sales teams. Founded in 2008 and headquartered in Burlington, Massachusetts, Qstream serves clients across various sectors, including technology, financial services, and life sciences. The company operates engineering facilities in Dublin, Ireland, and Hood River, Oregon, while maintaining sales headquarters in Maidenhead, United Kingdom, and an office in San Francisco. Qstream's micro-learning platform enables organizations to manage and measure the human aspects of sales performance, providing analytics-driven insights that facilitate team excellence.

SQZ Biotech is a clinical-stage biotechnology company focused on developing innovative cell therapies for cancer, infectious diseases, and other serious health conditions. Utilizing its proprietary CellSqueeze technology, the company can deliver a variety of materials into diverse patient cell types, enabling the engineering of therapies that address a wide range of clinical challenges. SQZ Biotech aims to create well-tolerated and effective cell therapies that enhance patient experiences compared to traditional approaches. With its commitment to internal research and strategic partnerships, SQZ is working to advance a new generation of cell therapies through both immune activation and immune suppression methods, showcasing its potential to transform treatment options for patients.

US HealthVest is a behavioral healthcare firm that focuses on transforming the psychiatric hospital sector. The company's business model centers on developing new facilities as well as acquiring existing ones that have untapped potential. Each facility is designed to provide a range of services tailored to meet the diverse needs of various patient populations. The leadership team at US HealthVest has a proven track record in the psychiatric hospital industry, having previously established and sold successful businesses, including Ascend Health, which operated nine freestanding facilities and nearly 900 beds before its acquisition by Universal Health Services in 2012. The firm's predecessor, Heartland Health Developments, also specialized in psychiatric care and was sold to Psychiatric Solutions in 2004.

Founded in 2014, Quartet Health operates a cloud-based platform facilitating communication between medical providers and behavioral health specialists for improved patient care. The platform works with health plans and systems to provide actionable insights on behavioral health conditions, enhancing patient outcomes.

Boxever Ltd. is a Dublin-based company that specializes in customer intelligence as a service for the travel industry. Founded in 2010, Boxever provides a digital optimization platform that leverages data and artificial intelligence to enhance customer interactions and experiences. Its main offerings include BOXEVER TX, which visualizes the customer journey, and TX-CORE, a traveler experience management solution that helps clients anticipate customer needs. Additionally, the platform features TX-NOW, an offer management tool, and serves as a comprehensive customer data platform (CDP) that integrates information from various online and offline sources. Boxever collaborates with prominent brands such as Emirates and Ryanair, aiming to transform customer engagement through personalized experiences and data-driven decision-making.

Scholar Rock is a biopharmaceutical company dedicated to discovering and developing innovative therapies targeting dysregulated growth factors in disease microenvironments. Its proprietary platform enables the creation of monoclonal antibodies that selectively modulate these proteins at the cellular level, potentially avoiding historical challenges associated with inhibiting growth factors. The company's lead product candidate, SRK-015, is a selective inhibitor of myostatin activation for treating neuromuscular disorders like spinal muscular atrophy.

Navitor Pharmaceuticals is a biopharmaceutical company developing targeted therapies for various diseases by modulating mTORC1 activity. Founded in 2009, the company is headquartered in Cambridge, Massachusetts.

ClearSky Data offers a global storage network that simplifies the entire data lifecycle. It provides an SLA-based managed service, continually categorizing and optimizing data across hot, warm, and cold cache layers based on evolving usage requirements. Customers can scale capacity easily via a dashboard, with all data movable for various use cases like migration or disaster recovery. ClearSky partners with major public clouds to offer low-latency access to cloud instances. Its service reduces total cost of ownership by approximately one-third compared to managing data in-house. The company ensures high availability and robust security through redundant architecture and industry-leading technologies.

AgBiome is a biotechnology company that develops biological products for agriculture by leveraging the plant-associated microbiome. It identifies plant microbes with potential to improve plant health, pest resistance, and yields, using genomics and screening technologies. The company builds a microbial collection and operates a platform to discover ingredients for agriculturally relevant applications, including fungicides and other biologics that target soil-borne diseases, insects, and nematodes. Through partnerships with agricultural players, AgBiome accelerates discovery and global deployment of solutions. It is based in Durham, North Carolina, with a state-of-the-art laboratory and greenhouse facility, and has a substantial research team.

Editas Medicine is a clinical-stage biotechnology company based in Cambridge, Massachusetts, with an additional site in Boulder, Colorado. Founded in 2013, the company focuses on the discovery and development of genome editing therapeutics, primarily utilizing its proprietary CRISPR/Cas9 technology. This innovative platform enables precise molecular modifications at the genetic level, with the aim of treating a wide array of serious diseases by addressing their underlying causes. Editas Medicine has established a strong intellectual property portfolio, which includes numerous patents related to foundational genome editing technologies and advancements that facilitate the translation of research into viable human therapeutics. The company's mission is to pioneer transformative genomic medicines that can significantly improve patient outcomes across various genetic disorders.

Arivale Inc. is a wellness services provider that focuses on helping individuals optimize their health and prevent diseases through a scientific approach. Founded in 2014 and headquartered in Seattle, Washington, the company analyzes various aspects of an individual's health, including genetics, blood markers, microbiome data, and lifestyle choices. By combining this personalized data with tailored coaching and support from a clinical team, Arivale delivers actionable recommendations to enhance wellness. Their program not only empowers individuals to make informed decisions regarding diet and exercise but also contributes to a longitudinal dataset that aids in the discovery of innovative health improvement methods. Overall, Arivale is dedicated to providing a comprehensive and intimate view of well-being to enhance the quality of life for its members.

Founded in 2008, Kissmetrics provides a unified platform for behavioral analytics, segmentation, and automated email campaigns. It helps online businesses understand customer behavior, measure key metrics, and optimize growth strategies.

Syros Pharmaceuticals, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, that specializes in developing innovative treatments for cancer and monogenic diseases through gene control medicines. The company is advancing its lead product candidates, including SY-1425, a selective retinoic acid receptor alpha agonist currently in Phase II clinical trials for specific patient populations with acute myeloid leukemia and myelodysplastic syndrome, and SY-5609, a cyclin-dependent kinase 7 inhibitor under investigation in a Phase I clinical trial for advanced solid tumors. Syros is also engaged in collaborative research, including a partnership with Incyte Corporation aimed at identifying therapeutic targets for myeloproliferative neoplasms and a licensing agreement with TMRC Co. Ltd. for the development of tamibarotene. With a focus on mapping gene regulatory circuits, Syros leverages its proprietary platform and expertise to address significant unmet medical needs in oncology. Founded in 2011, the company aims to establish new standards of care for patients with hematologic malignancies.

Recurly, Inc. is a provider of enterprise-class subscription management and billing solutions aimed at optimizing revenue growth for businesses across various industries, including digital media, streaming, publishing, SaaS, consumer goods, and professional services. Founded in 2009 and headquartered in San Francisco, California, with additional offices in Boulder, Colorado, and New Orleans, Louisiana, Recurly simplifies the complexities of subscription billing and revenue optimization. Its platform facilitates recurring billing automation, offering features such as customizable hosted billing pages, account management services, and actionable insights to enhance decision-making. By reducing subscriber churn and improving operational efficiency, Recurly enables businesses to quickly integrate payment solutions and focus on growth. The company is also a Level 1 PCI compliant service provider, which minimizes costs associated with PCI compliance for its clients.

Visterra is a clinical-stage biopharmaceutical company developing precision antibody-based medicines for hard-to-treat infectious and non-infectious diseases. It uses its Hierotope platform to engineer monoclonal antibodies targeting various pathogens, including influenza A, dengue virus, Pseudomonas aeruginosa, and Immunoglobulin A Nephropathy.

YourBio Health specializes in innovative blood sampling technologies. Their flagship product, Seventh Sense On Vivo™ platform, enables safe and painless diagnostic testing using proprietary Touch Activated Phlebotomy™ (TAP™) technology. This single-step process can be integrated with various diagnostic assays for rapid results, improving patient experience and accessibility to critical healthcare information.

Kala Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to developing and commercializing innovative therapies for eye diseases using its proprietary Mucus Penetrating Particles (MPP) technology. This technology enhances drug distribution and pharmacokinetics by coating mucosal surfaces with biocompatible, drug-loaded particles, allowing for improved local drug concentrations while minimizing systemic exposure. Kala's lead product candidate, KPI-121 0.25%, has completed two Phase III clinical trials aimed at providing temporary relief for dry eye disease. Additionally, INVELTYS has also completed two Phase III trials for managing inflammation and pain after ocular surgery. The company is advancing KPI-285, a receptor tyrosine kinase inhibitor, in preclinical studies targeting retinal diseases. Established in 2009 and headquartered in Watertown, Massachusetts, Kala Pharmaceuticals continues to explore diverse product opportunities while focusing on internal development and research collaborations to address significant clinical needs.

Suneva Medical develops, manufactures, and commercializes aesthetic products for dermatology and cosmetic surgery markets. Its flagship product, Bellafill, is a dermal filler used for correcting nasolabial folds and facial acne scars, with proven long-term safety and efficacy.

Arsanis, Inc. is a clinical-stage biopharmaceutical company headquartered in Waltham, Massachusetts, specializing in monoclonal antibody (mAb) immunotherapies for serious infectious diseases. Founded in 2010, Arsanis focuses on developing innovative therapies targeting various bacterial and viral pathogens. Its lead clinical program, ASN100, is currently in a Phase 2 trial aimed at preventing Staphylococcus aureus pneumonia in high-risk, mechanically ventilated patients. The company's preclinical pipeline includes mAbs directed against respiratory syncytial virus and Gram-negative bacteria, such as Klebsiella pneumoniae and Escherichia coli. Arsanis leverages advanced mAb discovery techniques to create a diverse range of therapeutic candidates with multiple mechanisms of action, addressing the urgent need for effective treatments in infectious disease management. The company also has research and preclinical development operations in Vienna, Austria, under Arsanis Biosciences GmbH.

Founded in 2008, Kissmetrics provides a unified platform for behavioral analytics, segmentation, and automated email campaigns. It helps online businesses understand customer behavior, measure key metrics, and optimize growth strategies.

Iora Health, Inc. is a healthcare organization based in Boston, Massachusetts, that specializes in providing primary care services across the United States. Founded in 2010, Iora Health focuses on redesigning primary care to eliminate barriers and enhance patient experience. Each patient is assigned a personal physician and a health coach, ensuring continuous support and communication through various channels, including email, text, and video, in addition to in-person visits. The company employs a team-based approach to care, which includes a doctor or nurse practitioner, a nurse, a behavioral health specialist, and a health coach, all supported by a proprietary technology platform that integrates population health management into the primary care workflow. Iora Health also offers educational programs, such as group visits, to help patients stay engaged with their health and achieve their wellness goals.

Receptos, Inc. is a clinical-stage biopharmaceutical company headquartered in San Diego, California, specializing in the discovery and development of therapeutics for immune disorders. The company’s lead product, ozanimod, is an oral therapy currently undergoing phase III trials for relapsing multiple sclerosis and phase II studies for ulcerative colitis and Crohn's disease. Additionally, Receptos is developing RPC4046, a monoclonal antibody in phase II trials for eosinophilic esophagitis, an immune-mediated condition. The company is also conducting preclinical research on glucagon-like peptide-1 receptor small molecule positive allosteric modulators for the treatment of Type 2 diabetes. Receptos was founded in 2008 and was formerly known as Receptor Pharmaceuticals, Inc. It became a subsidiary of Celgene Corporation in 2015.

Jibe Inc. is a provider of cloud-based recruiting technology solutions designed to assist talent acquisition teams in identifying, attracting, and engaging candidates globally. Founded in 2009 and based in New York, the company offers the Jibe Recruiting Cloud, a software-as-a-service platform that streamlines the hiring process. This platform features various applications, including tools for applying to jobs from multiple devices, enhancing employee referrals, and distributing job postings across various channels. Jibe's solutions cater to the needs of Fortune 500 companies, enabling them to optimize candidate experiences and leverage social networks for recruitment. With strategic partnerships with industry leaders such as Google and LinkedIn, Jibe continues to innovate within the talent acquisition space. It operates as a subsidiary of iCIMS, Inc. since 2019.

Localytics is a mobile app analytics and marketing platform that helps businesses enhance their mobile app acquisition, engagement, and retention strategies. It offers a suite of tools that integrate marketing capabilities—such as push notifications, in-app messaging, and email marketing—with robust analytics features. This allows companies to utilize real-time user data for personalized and automated marketing campaigns. Localytics serves over 6,000 apps across more than 2 billion devices, catering to notable clients like Live Nation, HSN, Comcast, and The New York Times. By focusing on mobile and web app engagement, Localytics equips organizations with the insights and tools necessary for improving user interaction and loyalty.

Pulmatrix is a clinical-stage biopharmaceutical company developing inhaled therapies to address serious pulmonary diseases using its patented iSPERSE technology. Its pipeline focuses on Pulmazole, an inhaled anti-fungal for allergic bronchopulmonary aspergillosis, and PUR1800, a narrow spectrum kinase inhibitor for obstructive lung diseases like asthma and COPD.

Fate Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, focused on developing programmed cellular immunotherapies for cancer and immune disorders. The company specializes in NK- and T-cell immuno-oncology programs, with a diverse pipeline that includes candidates such as FT516 and FT596 for treating various hematologic malignancies, FT538 for acute myeloid leukemia and multiple myeloma, and FT500 for advanced solid tumors. Fate Therapeutics employs advanced techniques involving induced pluripotent stem cells (iPSCs) to create engineered product candidates, which are designed to be off-the-shelf solutions. The company has established strategic collaborations with notable partners, including Ono Pharmaceutical Co. Ltd. and Janssen Biotech, to enhance its research and development capabilities. Founded in 2007, Fate Therapeutics aims to leverage cutting-edge science to create innovative therapies that restore health by modulating the properties of stem cells.

TARIS Biomedical, Inc. is a therapeutically focused urology company based in Lexington, Massachusetts, established in 2008. The company specializes in developing innovative treatments for challenging bladder diseases, including bladder cancer and overactive bladder. TARIS Biomedical's proprietary system is designed to continuously release medications directly into the bladder over extended periods, ranging from weeks to months. This technology is administered through minimally invasive, in-office procedures, allowing for customized drug delivery that aligns with the specific needs of various bladder conditions. As of December 2019, TARIS Biomedical operates as a subsidiary of Janssen Research & Development, LLC.

Living Proof, Inc. is a hair care product manufacturer based in Cambridge, Massachusetts, founded in 2005. The company specializes in developing innovative hair care solutions that address various beauty challenges through advanced technology and science-backed formulas. Its product range includes shampoos, conditioners, styling treatments, nourishing creams, and a variety of sprays and serums designed to enhance hair health and appearance. Living Proof's formulations are suitable for all hair types, including color-treated hair, ensuring that consumers can achieve their desired results. The company distributes its products via its online store and through salons, retailers, and specialty beauty stores across several countries, including the United States, Canada, the United Kingdom, Australia, Singapore, and Thailand. In August 2008, the company changed its name from Andora, Inc. and has operated as a subsidiary of Unilever PLC since February 2017.

Genocea Biosciences, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, focused on the discovery and development of innovative cancer immunotherapies and vaccines. Utilizing its proprietary ATLAS platform, the company profiles patient-specific CD4+ and CD8+ T cell immune responses to identify potential antigens in tumors. This technology enables Genocea to develop personalized immuno-oncology programs, including GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, as well as GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine program. Additionally, the company has pursued immunotherapies for other diseases, such as GEN-003, aimed at treating genital herpes, and it maintains a pre-clinical program focused on personalized cancer vaccines. Founded in 2006, Genocea is dedicated to addressing significant unmet medical needs through its advanced therapeutic approaches.

1366 Technologies Inc., established in 2008, specializes in the development, manufacturing, and supply of silicon wafers for solar cell applications. Based in Bedford, Massachusetts, with additional facilities in Shanghai, China, and Mumbai, India, the company produces both 3D direct wafers and conventional silicon solar wafers. Through strategic partnerships with Hanwha Q CELLS Malaysia Sdn. Bhd. and Hanwha Q CELLS Co., Ltd., 1366 Technologies supplies its products to major players in the solar industry. Its proprietary technology enables the production of silicon wafers directly from molten silicon, resulting in lower costs, reduced energy requirements, and improved uniformity compared to traditional methods. This allows businesses to create more efficient and cost-effective solar cells.

Follica, Inc. is a Boston-based company focused on developing innovative therapies for hair loss in adults. Established in 2005, Follica specializes in a proprietary treatment system that includes an in-office device designed to disrupt the skin and stimulate the creation of new hair follicles. Additionally, the company offers an at-home treatment system that delivers therapeutic compounds directly to the scalp, facilitating a daily hair care routine. Follica's approach targets conditions related to hair follicles, addressing a market that exceeds $10 billion annually and is characterized by a lack of effective solutions. The company's regenerative biology-based technology aims to not only create new hair follicles but also to thicken existing hair, providing clinicians with effective treatment options for their patients.

SiOnyx, Inc. is a company based in Beverly, Massachusetts, that specializes in advanced semiconductor technology focusing on shallow junction photonics. Founded in 2005, SiOnyx enhances the infrared sensitivity of silicon-based photonics, leading to significant improvements in light-sensing devices. The company develops ultra-low-light image sensors and night vision camera systems that cater to a diverse range of applications, including security, defense, consumer electronics, industrial, medical, and automotive sectors. Its product offerings include XQE CMOS image sensors, which enable functionalities such as night vision, biometrics, and eye-tracking, as well as HD action video cameras. SiOnyx is recognized for making digital night vision technology more accessible, thereby enhancing optoelectronic response in both visible and near-infrared regions.

1366 Technologies Inc., established in 2008, specializes in the development, manufacturing, and supply of silicon wafers for solar cell applications. Based in Bedford, Massachusetts, with additional facilities in Shanghai, China, and Mumbai, India, the company produces both 3D direct wafers and conventional silicon solar wafers. Through strategic partnerships with Hanwha Q CELLS Malaysia Sdn. Bhd. and Hanwha Q CELLS Co., Ltd., 1366 Technologies supplies its products to major players in the solar industry. Its proprietary technology enables the production of silicon wafers directly from molten silicon, resulting in lower costs, reduced energy requirements, and improved uniformity compared to traditional methods. This allows businesses to create more efficient and cost-effective solar cells.

Located in Cambridge, MA, Sun Catalytix is an early-stage renewable energy startup founded on groundbreaking science from the research lab of Professor Daniel Nocera at MIT. With Nature as our inspiration, we seek to combine sunlight and water to provide affordable, highly distributed solar energy to the individual. The elemental components of just 3 gallons of water have enough energy, when recombined, to satisfy the daily energy needs of a large American home. The US receives 500-fold more energy each year than it uses, but unfortunately the sun shines only half the time. At Sun Catalytix we are working to realize the dream of cheap, renewable, personalized energy allowing individuals to use the power around-the-clock. Backed by Polaris Venture Partners, we have started down the path to a sustainable energy future.

Trevena, Inc., founded in 2007 and headquartered in Chesterbrook, Pennsylvania, is a biopharmaceutical company dedicated to the development of innovative medicines for central nervous system (CNS) disorders. The company specializes in creating G protein-coupled receptor (GPCR) biased ligands, which aim to improve upon existing therapies by enhancing efficacy and reducing adverse effects. Trevena's pipeline includes several product candidates: Oliceridine injection, a mu-opioid receptor ligand completed Phase III trials for acute pain management; TRV250, a delta-opioid receptor agonist in Phase I study for migraine treatment; TRV734, a small molecule MOR ligand in Phase I study for acute and chronic pain; TRV027, currently in phase 2 clinical testing for the treatment of acute heart failure; and TRV045, an S1P modulator for managing chronic pain. Trevena has also collaborated with Imperial College London to evaluate Trv027 in Covid-19 patients.

Follica, Inc. is a Boston-based company focused on developing innovative therapies for hair loss in adults. Established in 2005, Follica specializes in a proprietary treatment system that includes an in-office device designed to disrupt the skin and stimulate the creation of new hair follicles. Additionally, the company offers an at-home treatment system that delivers therapeutic compounds directly to the scalp, facilitating a daily hair care routine. Follica's approach targets conditions related to hair follicles, addressing a market that exceeds $10 billion annually and is characterized by a lack of effective solutions. The company's regenerative biology-based technology aims to not only create new hair follicles but also to thicken existing hair, providing clinicians with effective treatment options for their patients.

ShoeDazzle is a fashion subscription service that offers a personalized online boutique experience, specializing in women's footwear and accessories. The company provides a VIP Elite Membership for a monthly fee, which allows members to earn "VIP Credits" that can be used to purchase exclusive and brand-name shoes, handbags, and more. Each month, ShoeDazzle showcases a new selection of products tailored to each client's individual style preferences through a customized online showroom. The service is designed to enhance the shopping experience by delivering personalized styling for footwear, making it easier for customers to find products that suit their tastes. Rachel Zoe serves as the Chief Stylist, contributing to the company's fashion-forward approach.

Apnex Medical is a medical device company focused on implantable therapies for sleep-disordered breathing. Its signature product, the Apnex HGNS System, is an implantable device designed to activate the muscles of the upper airway to keep the airway open during sleep, with programmable operation and a handheld controller for on-demand use. Founded in 2006 and based in Saint Paul, Minnesota, Apnex Medical develops technology intended to improve treatment options for obstructive sleep apnea.

Genocea Biosciences, Inc. is a biopharmaceutical company based in Cambridge, Massachusetts, focused on the discovery and development of innovative cancer immunotherapies and vaccines. Utilizing its proprietary ATLAS platform, the company profiles patient-specific CD4+ and CD8+ T cell immune responses to identify potential antigens in tumors. This technology enables Genocea to develop personalized immuno-oncology programs, including GEN-009, an adjuvanted neoantigen peptide vaccine currently in phase I/IIa clinical trials, as well as GEN-011, a neoantigen adoptive T cell therapy, and GEN-010, a neoantigen vaccine program. Additionally, the company has pursued immunotherapies for other diseases, such as GEN-003, aimed at treating genital herpes, and it maintains a pre-clinical program focused on personalized cancer vaccines. Founded in 2006, Genocea is dedicated to addressing significant unmet medical needs through its advanced therapeutic approaches.

Fate Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in San Diego, California, focused on developing programmed cellular immunotherapies for cancer and immune disorders. The company specializes in NK- and T-cell immuno-oncology programs, with a diverse pipeline that includes candidates such as FT516 and FT596 for treating various hematologic malignancies, FT538 for acute myeloid leukemia and multiple myeloma, and FT500 for advanced solid tumors. Fate Therapeutics employs advanced techniques involving induced pluripotent stem cells (iPSCs) to create engineered product candidates, which are designed to be off-the-shelf solutions. The company has established strategic collaborations with notable partners, including Ono Pharmaceutical Co. Ltd. and Janssen Biotech, to enhance its research and development capabilities. Founded in 2007, Fate Therapeutics aims to leverage cutting-edge science to create innovative therapies that restore health by modulating the properties of stem cells.

Pulmatrix is a clinical-stage biopharmaceutical company developing inhaled therapies to address serious pulmonary diseases using its patented iSPERSE technology. Its pipeline focuses on Pulmazole, an inhaled anti-fungal for allergic bronchopulmonary aspergillosis, and PUR1800, a narrow spectrum kinase inhibitor for obstructive lung diseases like asthma and COPD.

Cerulean Pharma Inc. is a privately-held biopharmaceutical company specializing in the development of innovative nanotechnology-based therapeutics, primarily targeting oncology, cardiovascular, autoimmune, and inflammatory diseases. The company focuses on creating nanoparticle-drug conjugates that aim to selectively target tumors, minimize toxicity, and facilitate drug combinations. Among its notable products is Ovaprene, a contraceptive designed to offer multiple weeks of protection without hormones, addressing needs in fertility and vaginal health. Cerulean Pharma boasts a distinguished management team and advisory board, comprising experts with extensive experience in product development and scientific advancements from leading organizations and institutions, including GlaxoSmithKline, Merck, and Harvard Medical School.

Hangout is building the next generation in social gaming by combining the powerful community of social networks with the rich immersion and engaging casual game-play of a 3D virtual world. Play Games, Go Shopping, Throw Parties for Causes in Hangout Teen girls (and later guys) create their own personalized avatars, play casual mini-games, go shopping, throw parties for their friends, or just hangout. Playing games earns money for fashionable looks, new moves on the dance floor, or money to give to charity. At launch, players will be able to begin building their fashion empire as they level up to become a top fashion designer. Soon they can also aspire to become a dance master or the ultimate chef in order to throw the party of a lifetime, all in the name of a real charity of their choice. Hangout is about having fun with friends, meeting new people, and making a difference! Hangout Uniquely Integrates Social Games with a Virtual World Each game te publish seamlessly plugs into the same virtual world, so players keep their avatars, possessions, and status from game to game. The integrated publishing approach results in improved cross-promotion and better player retention and monetization.

VKernel Corporation, founded in 2007 and acquired by Quest Software in 2011, is a leading provider of performance and capacity management solutions specifically designed for VMware and Microsoft virtualized environments. The company specializes in developing virtual appliances that monitor and manage resources across virtual server infrastructures, enabling enterprises to optimize their capacities and minimize virtualization costs. VKernel's products assess critical metrics such as CPU, network, memory, and storage, thereby addressing performance bottlenecks and enhancing overall application performance. With a user base of over 50,000 system administrators, the company has established a strong presence in both the United States and Europe. Its solutions are distributed directly and through a global network of resellers, positioning VKernel to meet the increasing demand for effective management tools in virtual and cloud-based environments.