Pioneer Fund

Olio Labs is a biotechnology company focused on developing combination therapeutics that leverage artificial intelligence to enhance treatment efficacy and reduce side effects. By employing automated discovery methods, the company analyzes protein interactions in the body, allowing for a more comprehensive approach to therapeutic design. Unlike traditional methods that typically target a limited number of proteins, Olio Labs' innovative strategy aims to create effective treatment solutions that consider a wider range of interacting proteins, ultimately improving patient outcomes.

Mdhub is a technology company specializing in mental health. It offers a clinical AI assistant designed for mental health clinicians, automating the creation of structured clinical notes, patient summaries, and treatment plans. This streamlines administrative tasks, potentially saving clinicians up to two hours per day. The platform adheres to HIPAA's data processing and storage protocols, ensuring the security and privacy of patient information. By reducing manual documentation, Mdhub enables clinicians to focus more on patient treatment and care.

ParcelBio is a biotechnology company specializing in the development of a novel, programmable method for safely and precisely delivering messenger RNA (mRNA) to diverse cell types within the body. Their technology aims to create targeted, potent, and durable RNA therapeutics, with the potential to treat a wide range of diseases, including cancer, genetic disorders, and infectious diseases.

Olio Labs is a biotechnology company focused on developing combination therapeutics that leverage artificial intelligence to enhance treatment efficacy and reduce side effects. By employing automated discovery methods, the company analyzes protein interactions in the body, allowing for a more comprehensive approach to therapeutic design. Unlike traditional methods that typically target a limited number of proteins, Olio Labs' innovative strategy aims to create effective treatment solutions that consider a wider range of interacting proteins, ultimately improving patient outcomes.

MantleBio is a medical technology company focused on developing software that enhances data-driven discovery in the biotechnology sector. Its platform is designed to manage and analyze biological data, streamlining the drug discovery process. By providing tools that assist scientists and computational biologists in handling high-throughput experiments, MantleBio enables biotech companies to utilize advancements in computational science and machine learning effectively. Through its innovative approach, the company aims to accelerate the development of new therapeutics and improve research efficiency within the industry.

MICSI develops AI-driven software that enhances image quality using random matrix theory denoising. Its platform improves signal-to-noise ratio, resolution, and image quality in magnetic resonance imaging (MRI), enabling faster scan times and optimized image reconstruction for clinical applications.

MediSearch is a technology company that develops a search engine platform. This platform is designed to deliver direct, science-based answers to medical questions, empowering users to make informed decisions about their health and well-being. It offers a user-friendly interface, expert-curated information, and reliable sources, making it a trusted resource for those seeking health or bioscience insights.

Intelliga Health is an artificial intelligence company focused on optimizing insurance workflows for medical practices. Its platform automates the process of insurance authorization appeals by analyzing previous successful appeals to generate personalized appeal letters for healthcare providers. This approach not only saves time for medical professionals but also increases the likelihood of successful authorization for necessary treatments. In addition to managing appeal processes, Intelliga Health’s platform monitors technical infrastructure and ensures compliance, providing a comprehensive solution that enhances operational efficiency within healthcare settings.

OpenShelf specializes in automated inventory management solutions. Founded in 2023, the company operates modular robotics systems designed to handle and track a wide variety of items efficiently. OpenShelf's open-source hardware and software platforms offer businesses simplified inventory management while maintaining transparency.

iollo, founded in 2022 and based in San Francisco, offers metabolomics testing to support wellbeing and aging. The company develops at-home blood test kits that monitor biomarkers across heart, kidney, liver function, the microbiome, and metabolic health, measuring molecules in blood to provide personalized insights. Its service links biomarker data to dietary, behavioral, and therapeutic interventions, delivering recommendations aimed at improving wellness and managing aging. iollo emphasizes convenient, at-home testing and automated interpretation to help individuals make informed lifestyle choices and track health over time.

Medplum offers an open-source developer platform designed to simplify healthcare application development. It focuses on streamlining workflow automation, secure data storage, and providing UI components tailored for healthcare.

Viosera Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapies to combat antibiotic resistance, particularly targeting methicillin-resistant Staphylococcus aureus (MRSA). Founded in July 2016, the company is headquartered in Sunnyvale, California, with additional operations in St. Louis, Missouri. Viosera's flagship product, VT1, is designed to treat MRSA bloodstream infections. The company employs artificial intelligence to identify and develop drug combinations that predict and block resistance evolution in both bacterial infections and cancer treatment. Through these advancements, Viosera aims to provide effective solutions that address the growing threat of antibiotic resistance, ultimately improving patient outcomes.

Reframe is an app to help people cut back on alcohol use and build healthier habits

Orange Health is a health technology company that facilitates remote diagnostic lab services for patients, allowing doctors to provide real-time care. Its platform focuses on patient-centric home sample collection and testing, aiming to make healthcare more accessible and efficient.

Promakhos Therapeutics develops immunotherapies focused on treating inflammatory diseases. Their platform is centered around bacterial molecules designed to stimulate the body's innate ability to control inflammation and promote healing, without immune suppression.

Axle Health specializes in software for home healthcare providers. Its platform offers scheduling, workforce management, patient engagement, and logistics optimization tools. Integrated with various EMRs, Axle's customizable solutions improve clinical team utilization and automate operational tasks.

Terra facilitates seamless health data exchange. It connects applications with various wearables, sensors, and blood labs.

Axle Health specializes in software for home healthcare providers. Its platform offers scheduling, workforce management, patient engagement, and logistics optimization tools. Integrated with various EMRs, Axle's customizable solutions improve clinical team utilization and automate operational tasks.

Terra facilitates seamless health data exchange. It connects applications with various wearables, sensors, and blood labs.

Orange Health is a health technology company that facilitates remote diagnostic lab services for patients, allowing doctors to provide real-time care. Its platform focuses on patient-centric home sample collection and testing, aiming to make healthcare more accessible and efficient.

54gene is a biotechnology company founded in 2019 and headquartered in San Francisco, California, with additional offices in Lagos, Nigeria. The company focuses on unlocking the potential of the African genome to enhance genetic research and development, addressing a significant gap in the global genomics market where a majority of genetic data is derived from individuals of Caucasian descent. By developing a pan-African biobank, 54gene aims to identify new drug targets and create diagnostics and treatments for various diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders. In addition to its research initiatives, the company offers genetic testing and molecular diagnostics services to patients and healthcare providers, ensuring compliance with international data privacy laws. Through its efforts, 54gene seeks to contribute to the discovery of medical advancements that can benefit diverse populations.

Felix Biotechnology, Inc. is a San Francisco-based company founded in 2019 that specializes in developing biotherapeutics to combat microbial challenges in human health. The company focuses on creating treatments for antibiotic-resistant strains of bacteria and fungi, aiming to address the urgent need for effective management of infectious diseases. By accelerating the deployment of novel biotherapeutics, Felix Biotechnology seeks to provide healthcare professionals with precise and effective tools to tackle these pressing health issues.

Digi-Prex is a healthcare company that operates a monthly medication delivery platform focused on chronic disease management. Founded in 2019 and headquartered in Hyderabad, India, with an additional office in San Francisco, California, the company enables patients to manage their conditions more effectively. Digi-Prex provides a subscription service that offers discounted medications based on prescriptions uploaded by patients. The platform ensures regular delivery of these medicines from local pharmacies, making it a cost-effective solution for patients. In addition to medication delivery, Digi-Prex offers a comprehensive service tailored to the unique needs of each patient, creating a one-stop solution for managing chronic health conditions.

54gene is a biotechnology company founded in 2019 and headquartered in San Francisco, California, with additional offices in Lagos, Nigeria. The company focuses on unlocking the potential of the African genome to enhance genetic research and development, addressing a significant gap in the global genomics market where a majority of genetic data is derived from individuals of Caucasian descent. By developing a pan-African biobank, 54gene aims to identify new drug targets and create diagnostics and treatments for various diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders. In addition to its research initiatives, the company offers genetic testing and molecular diagnostics services to patients and healthcare providers, ensuring compliance with international data privacy laws. Through its efforts, 54gene seeks to contribute to the discovery of medical advancements that can benefit diverse populations.

Raksha Health facilitates accessible healthcare services across India by collaborating with a vast network of hospital partners.

DailyDoctor offers remote patient monitoring services, connecting patients with independent physicians specializing in conditions like lung disease, stroke, heart failure, and blood pressure. Services are covered by Medicare and select insurers.

Viosera Therapeutics, Inc. is a biopharmaceutical company focused on developing innovative therapies to combat antibiotic resistance, particularly targeting methicillin-resistant Staphylococcus aureus (MRSA). Founded in July 2016, the company is headquartered in Sunnyvale, California, with additional operations in St. Louis, Missouri. Viosera's flagship product, VT1, is designed to treat MRSA bloodstream infections. The company employs artificial intelligence to identify and develop drug combinations that predict and block resistance evolution in both bacterial infections and cancer treatment. Through these advancements, Viosera aims to provide effective solutions that address the growing threat of antibiotic resistance, ultimately improving patient outcomes.

NanoCheq LLC is a company that develops and delivers advanced diagnostic tools aimed at detecting bacterial and chemical contaminants. Founded in 2018 and based in Phoenix, Arizona, NanoCheq provides BacCheQ testing devices that assist craft breweries and cosmetics manufacturers in identifying and eliminating microbial contamination. These devices can determine genus, strain type, and serotype, as well as analyze the presence of bacteria in food and drink samples. Additionally, the company offers a software platform that automates risk analysis and provides recommendations for eradicating pathogens in samples. NanoCheq specializes in custom solutions for the detection of volatile or liquid chemicals, utilizing a core technology based on aptamer-conjugated nanoparticles to enhance the accuracy and efficiency of its diagnostic tools.

Scanwell Health, Inc. is a healthcare company that specializes in at-home diagnostic solutions, focusing on urine testing kits. Founded in 2018 and headquartered in Los Angeles, California, Scanwell Health has developed an FDA-cleared urine testing application that allows users to obtain clinical-grade results via their smartphones. The company's flagship product is a urinary tract infection test kit that not only provides accurate testing results but also connects users with online medical professionals for same-day treatment and prescriptions. By combining innovative technology with accessible healthcare services, Scanwell Health aims to enhance proactive health management for individuals seeking convenient and affordable medical care.

HeyDoctor is an online healthcare provider that offers accessible and affordable medical services for common health issues. The company allows users to initiate consultations at their convenience, often completing visits in as little as five minutes without the need for insurance. Its range of services includes UTI testing, acne diagnosis, cold sore management, birth control prescriptions, HIV testing, erectile dysfunction treatment, and smoking cessation support. By enabling users to communicate with doctors through text messaging, HeyDoctor aims to streamline the healthcare experience, eliminating the need for traditional waiting rooms and providing timely medical attention.

Biobot Analytics, Inc. is a wastewater epidemiology company based in Cambridge, Massachusetts, founded in 2017. It specializes in transforming wastewater infrastructure into public health observatories through innovative technology that analyzes sewage for health-related data. By deploying proprietary sampling devices and spatial analytics, Biobot measures various health threats, including infectious diseases, antibiotic resistance, and drug consumption patterns. The company's Opioid Consumption Monitoring Program specifically estimates opioid use in urban areas by analyzing wastewater. This approach generates anonymized public health data that is independent of traditional hospital reporting systems, allowing for rapid adaptability to emerging public health threats. Biobot Analytics offers its insights as a service, providing government officials with actionable data to prioritize interventions and address public health challenges effectively.

WorkDone is a technology company specializing in AI-driven compliance solutions for the healthcare industry. Its core product is an AI compliance copilot that integrates with hospital electronic health record systems, monitoring clinical workflows in real-time to identify and address documentation errors, such as missed discharge notes or incorrect medication times. This proactive approach helps hospitals prevent medical documentation errors and potential associated losses.