OrbiMed

Miaoshou Doctor is a healthcare service platform established in 2015 by Tao He and Daoliang Han, headquartered in Beijing. The company focuses on facilitating communication between patients and healthcare professionals, enabling effective management of post-diagnosis outcomes. Its platform empowers doctors to actively monitor their patients' health through ongoing counseling and prescription support, enhancing the overall patient care experience. By streamlining interactions and follow-ups, Miaoshou Doctor aims to improve health outcomes and foster better relationships between patients and their healthcare providers.

Beijing Yuanxin is a technology company that offers an integrated healthcare platform for pharmaceutical distribution and health insurance.

Yuanxin Huibao is a health insurance technology service provider that specializes in medical insurance for major and chronic diseases. The company focuses on enhancing user experiences by offering comprehensive medical coverage, which includes features such as special drug services, video consultations, welfare drugs, and claims investigations. By integrating these services, Yuanxin Huibao aims to deliver more reliable medical solutions to its users while also providing insurance companies with a one-stop solution for risk control, pricing, and user acquisition.

Founded in 2003, Jinxin Fertility Group is a leading provider of assisted reproductive services (ARS), primarily offering artificial insemination and IVF technologies. It also provides ancillary services such as nutrition guidance, Chinese medicine treatment, psychological counseling, gynecology, urology, internal medicine, ambulatory surgery center facilities, and management services. With subsidiaries in China and the United States, Jinxin Fertility Group operates three assisted reproductive technology centers.

Health Catalyst is a technology company that specializes in data and analytics solutions for healthcare organizations. The company offers a platform that organizes, normalizes, and links health-related data from various systems, making it accessible and searchable for all users, including those without technical expertise. Health Catalyst operates through two main segments: the Technology segment, which generates the majority of its revenue through cloud-based subscriptions, time-based licenses, and maintenance fees for its data platforms and analytics applications; and the Professional Services segment, which provides a range of services including analytics, implementation, strategic advisory, and outsourcing to help clients optimize their use of the technology. By integrating and analyzing healthcare data, Health Catalyst aims to enhance decision-making and improve outcomes in the healthcare sector.

Avedro, Inc. is a commercial-stage ophthalmic pharmaceutical and medical device company headquartered in Waltham, Massachusetts. The company specializes in developing and commercializing innovative products for treating corneal disorders, primarily focusing on corneal ectatic conditions and refractive issues. Avedro's proprietary Corneal Remodeling Platform includes the KXL and Mosaic systems, which utilize ultraviolet A (UVA) light in conjunction with riboflavin drug formulations for corneal cross-linking. This technology is aimed at strengthening and reshaping the cornea through minimally invasive and non-invasive outpatient procedures. Avedro has also introduced the Keraflex refractive correction procedure, a non-invasive technique for flattening the cornea without tissue removal. While Avedro primarily serves ophthalmologists, hospitals, and ambulatory surgery centers in the United States, it also markets its products internationally through medical device distributors. The company, originally named ThermalVision, Inc., was incorporated in 2002 and rebranded as Avedro in 2005. As of November 2019, Avedro operates as a subsidiary of Glaukos Corporation.

Constellation Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, focused on developing innovative therapeutics for unmet medical needs in cancer treatment. The company specializes in the field of epigenetics, aiming to address cancers associated with abnormal gene expression and drug resistance. Its lead product candidates include CPI-0610, which is undergoing Phase II clinical trials for myelofibrosis in combination with ruxolitinib, and CPI-1205, currently in Phase Ib/II trials for metastatic castration-resistant prostate cancer in conjunction with androgen receptor signaling inhibitors. Additionally, Constellation is developing CPI-0209, which is in the Phase I dose escalation stage of a Phase I/II trial aimed at treating solid tumors. Founded in 2008, the company was previously known as Epigenetix, Inc. before rebranding to its current name in March 2008.

Founded in 2003, Atox Bio is a biotechnology company specializing in immunomodulators for treating critically ill patients with severe infections. Its focus lies in developing novel modulators targeting key pathways of the adaptive and innate immune response to improve outcomes in critical care settings.

Inspire Medical Systems, Inc. is a medical technology company dedicated to developing and commercializing minimally invasive solutions for patients suffering from obstructive sleep apnea (OSA). Founded in 2007 and headquartered in Golden Valley, Minnesota, the company specializes in innovative implantable neurostimulation technologies. Its primary product, the Inspire system, utilizes a proprietary Upper Airway Stimulation (UAS) therapy that provides a safe and effective treatment for moderate to severe OSA. This technology leverages established principles from cardiac pacing and neurostimulation to deliver mild hypoglossal nerve stimulation, which helps maintain an open airway by continuously monitoring the patient's breathing. Inspire Medical Systems operates primarily in the United States and Europe, generating most of its revenue from the U.S. market.

Natera, Inc. is a diagnostic and research company specializing in genetic testing services, particularly in the areas of preconception and prenatal diagnostics. Founded in 2003 and headquartered in San Carlos, California, Natera offers a range of products including the Panorama non-invasive prenatal test, which screens for chromosomal abnormalities in fetuses, and Vistara, a test for single-gene mutations. Additionally, the company provides Horizon carrier screening to assess carrier status for various genetic diseases, and Spectrum, which analyzes genetic conditions during in vitro fertilization. Natera's Anora product analyzes fetal chromosomes to understand miscarriage causes, while its non-invasive paternity tests determine parentage through fetal DNA analysis. The company's Signatera technology focuses on circulating tumor DNA to monitor cancer recurrence. Natera distributes its products through a direct sales force and a network of approximately 100 laboratory and distribution partners, both domestically and internationally. The company collaborates with BGI Genomics to develop genetic testing assays and has partnered with Foundation Medicine for personalized cancer monitoring assays.

Invitae is a genetic information company focused on integrating genetic insights into everyday medical practice to enhance healthcare quality for a large population. The company specializes in genetic diagnostics for hereditary disorders, offering a comprehensive service that consolidates multiple genetic tests into a single platform. Invitae's offerings include assessments for genes linked to hereditary cancer, neurological disorders, cardiovascular conditions, pediatric issues, metabolic disorders, and other hereditary ailments. By providing high-quality testing with quicker turnaround times and competitive pricing, Invitae aims to make genetic testing more accessible and effective for patients and healthcare providers alike.

Glaukos is an ophthalmic medical technology company focused on developing and commercializing products and procedures to transform the treatment of glaucoma, corneal disorders, and retinal diseases. It pioneered Micro-Invasive Glaucoma Surgery (MIGS) to provide less invasive options for glaucoma management, launching its first MIGS device, iStent, in the United States in 2012. The company is building a platform of injectable micro-scale therapies designed to address the full range of glaucoma disease states and progression. In addition to MIGS, Glaukos is advancing dropless therapies and long-duration intracameral drug delivery with iDose TR, and markets a proprietary therapy for the treatment of keratoconus. Through these approaches, Glaukos aims to improve patient outcomes and reduce treatment burden by offering durable, minimally invasive solutions for eye diseases.

Singulex develops and commercializes single molecule counting technology for clinical diagnostics and scientific discovery. Its flagship product, the Sgx Clarity System, enables ultra-sensitive detection of biomarkers down to femtograms/mL, aiding in cardiovascular health management and personalized wellness programs. Singulex serves pharmaceutical R&D labs, clinical research organizations, and academic institutions worldwide.

Acadia Pharmaceuticals is a biopharmaceutical company dedicated to developing and commercializing small molecule drugs targeting unmet medical needs in central nervous system disorders. Its primary product, NUPLAZID (pimavanserin), treats hallucinations and delusions associated with Parkinson's disease psychosis.