OrbiMed

Alentis Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapies for cancer and fibrotic diseases, including liver fibrosis, cirrhosis, and liver cancer. It pursues CLDN1-targeted approaches, developing anti-CLDN1 antibodies and antibody-drug conjugates to modify disease progression in CLDN1-positive cancers. Founded in 2019 and based in Basel, Switzerland, the company advances programs that aim to modulate the immune response and enhance anti-tumor activity while addressing liver-related conditions.

BioAge Labs develops medicines to treat aging and age-related diseases using its proprietary BioAge platform, which combines systems biology and AI. Its pipeline includes BGE-117 for multiple aging-related conditions, BGE-175 for immune aging and respiratory infections, and azelaprag for obesity in the elderly.

Fore Biotherapeutics is a precision oncology company focused on developing targeted cancer therapies guided by functional genomics. It aims to create a pipeline of treatments for patients with currently unaddressed mutations across established oncology targets.

XtalPi is a pharmaceutical technology company that applies quantum mechanics, artificial intelligence, and high-performance computing to accelerate drug discovery and development. Its Intelligent Digital Drug Discovery and Development platform weaves physics-based modeling with AI to increase efficiency, accuracy, and success rates at critical stages of R&D. The company offers tools for crystal structure prediction and determination, solid-state testing and analysis, and crystallization process development, as well as solid-state screening and evaluation, enabling faster optimization of drug candidates. XtalPi also provides drug design support for small molecules and collaboration options in antibody and peptide research, and offers platform-based AI model development and integration across pharmaceutical workflows. Founded in 2014, it is based in Cambridge, Massachusetts, with additional offices in China.

Rimag is a Shenzhen‑based medical imaging service provider that operates a network of imaging centers offering MRI, CT, PET, X‑ray, ultrasound and mammography. The company also develops cloud‑based imaging solutions and provides training for medical imaging professionals. Its revenue is primarily derived from the operation of imaging centers, while additional income comes from imaging solution services and cloud services.

Turnstone Biologics is a clinical-stage biotechnology company focused on developing viral immunotherapies to improve cancer survival. Its lead candidate, RIVAL-01, combines three immunomodulators to stimulate immune activity and reprogram the tumor microenvironment.

Crossover Health designs and delivers workplace healthcare services for employers and employees, offering primary care and a broad range of ancillary and advanced services, including urgent and preventive care, chronic disease management, health risk assessment, health education, coaching, biometrics, physical therapy, chiropractic, acupuncture, care coordination, health analytics, and remote care. It operates as a primary care medical group that blends health management services with technology-enabled tools to create a comprehensive employee care experience. Founded in 2010 and based in California, Crossover Health serves client organizations through on-site and partner health centers across Silicon Valley and other U.S. locations, with a focus on improving access to care, enhancing member experience, and reducing healthcare costs for employers and their workforce.

Abbisko Therapeutics is a clinical-stage biopharmaceutical company focused on discovery and development of differentiated small-molecule oncology therapies. Based in Shanghai, China, and founded in 2016, the company emphasizes immuno-oncology and aims to advance cancer treatments through in-house research and development, with a focus on therapies for hepatocellular carcinoma and solid tumors.

Decibel Therapeutics, Inc. is a clinical-stage biotechnology company focused on discovering and developing innovative therapies aimed at protecting, repairing, and restoring hearing. The company addresses various hearing disorders, including those related to pediatric cancers, cystic fibrosis, noise exposure, age-related and genetic hearing loss, as well as conditions characterized by persistent tinnitus. Decibel Therapeutics employs a multifaceted approach that includes drug delivery to the inner ear, advanced imaging techniques, and pharmacokinetic and pharmacodynamic modeling. The company leverages its expertise in inner ear biology, single-cell genomics, and bioinformatics to develop effective treatments for hearing loss and related disorders. Established in 2013 and headquartered in Boston, Massachusetts, Decibel Therapeutics was originally known as Hearing, Inc. before rebranding in 2014.

Cytek Biosciences, Inc. is a manufacturer and supplier of flow cytometry tools and equipment specifically designed for cancer and cell biology research. The company offers advanced flow cytometers, including the Cytek Aurora and Cytek Northern Lights, as well as the DxP Athena system, which utilizes proprietary technology to enhance the detection of dim populations in a multicolor format. In addition, Cytek provides the QbSure quality control program to ensure the optimal performance of its cytometers and a range of cFluor reagents tailored for use in multicolor applications. Established in 1990 and headquartered in Fremont, California, Cytek has expanded its presence internationally with locations in Bethesda, Maryland; Amsterdam, the Netherlands; Tokyo, Japan; and Shanghai, China. The company was previously known as Cytoville, Inc. before rebranding in August 2015.

InventisBio Inc. is a biotechnology company focused on discovering and developing innovative therapeutics for cancer and metabolic diseases. Founded in 2013 and based in Pudong, China, the company has developed a range of small molecule drug candidates targeting lung cancer, breast cancer, and gout. Among its notable products is D-0316, a third-generation EGFR-T790M tyrosine kinase inhibitor. InventisBio is also engaged in creating targeted immuno-oncology therapies that can be used in combination with existing treatments, such as PD-1 antibodies, to address various cancer indications. Co-founded by Dr. Yaolin Wang and a team of scientists with extensive experience in drug discovery at major pharmaceutical companies, InventisBio aims to provide effective therapies for significant health challenges.

Galecto is a clinical-stage biotechnology company developing small molecule therapeutics targeting galectin-3 and lysyl oxidase-like 2 for treating severe diseases like fibrosis and cancer. Its lead product candidate, GB0139, is an inhaled inhibitor of galectin-3 for treating severe fibrotic lung diseases such as idiopathic pulmonary fibrosis.

PMV Pharmaceuticals, Inc. is a precision oncology company focused on the discovery and development of small molecule therapies targeting p53 mutations in cancer. Its lead candidate, PC14586, aims to correct and restore the function of the p53 protein, which is critical in regulating cell growth and preventing tumor formation. In addition to PC14586, the company is developing therapies for various p53 hotspot mutations, including the R273H mutation. Founded in 2013 and headquartered in Cranbury, New Jersey, PMV Pharmaceuticals leverages extensive expertise in p53 biology to advance its innovative treatment options for cancer patients.

TytoCare develops handheld devices and software that enable users to perform self-examinations, facilitating remote diagnosis by healthcare professionals. The company's tools allow examination of various body areas and diagnose common conditions. TytoCare offers solutions for consumers (TytoHome), professionals (TytoPro), and remote clinics (TytoClinic). Incorporated in 2011, the company is headquartered in Netanya, Israel with an additional office in New York.

Founded in 2012, Akeso Biopharma operates as a contract research organization (CRO) specializing in antibody and protein drug discovery and development. It offers integrated platforms for services such as protein expression and purification, gene-to-structure analysis, antibody generation, assay development, humanization, and affinity maturation. Serving both domestic and international biotech and pharmaceutical clients, Akeso Biopharma is headquartered in Zhongshan, China.

ORIC Pharmaceuticals is a clinical-stage biopharmaceutical company dedicated to improving patients' lives by developing therapies that overcome resistance in cancer. Its lead product candidate, ORIC-101, targets the glucocorticoid receptor linked to resistance across various solid tumors. ORIC's second product candidate, ORIC-533, inhibits CD73 to address resistance to chemotherapy and immunotherapy. The company is also developing precision medicines targeting other cancer resistance mechanisms.

Acutus Medical designs, manufactures, and markets tools for catheter-based ablation procedures to treat various cardiac arrhythmias worldwide. Its product portfolio includes access sheaths, transseptal crossing tools, diagnostic catheters, ablation catheters, mapping consoles, and supporting software.

Tricida, Inc. is a late-stage pharmaceutical company based in South San Francisco, California, established in 2013. The company specializes in the development and commercialization of TRC101, a non-absorbed, orally-administered polymer designed to treat metabolic acidosis in patients with chronic kidney disease (CKD). Metabolic acidosis, a common complication of CKD, can accelerate kidney deterioration and is associated with serious health risks, including muscle wasting and loss of bone density. Tricida has successfully completed a Phase 3, double-blind, placebo-controlled trial of TRC101, positioning the company to address a significant unmet medical need in CKD management through the innovative approach of binding and removing acid from the gastrointestinal tract.

Arsanis, Inc. is a clinical-stage biopharmaceutical company headquartered in Waltham, Massachusetts, specializing in monoclonal antibody (mAb) immunotherapies for serious infectious diseases. Founded in 2010, Arsanis focuses on developing innovative therapies targeting various bacterial and viral pathogens. Its lead clinical program, ASN100, is currently in a Phase 2 trial aimed at preventing Staphylococcus aureus pneumonia in high-risk, mechanically ventilated patients. The company's preclinical pipeline includes mAbs directed against respiratory syncytial virus and Gram-negative bacteria, such as Klebsiella pneumoniae and Escherichia coli. Arsanis leverages advanced mAb discovery techniques to create a diverse range of therapeutic candidates with multiple mechanisms of action, addressing the urgent need for effective treatments in infectious disease management. The company also has research and preclinical development operations in Vienna, Austria, under Arsanis Biosciences GmbH.

Nutrinia Ltd. is a neonatology company focused on developing pharmaceuticals to address rare gastrointestinal conditions in infants. Based in Ramat-Gan, Israel, the company has created oral formulations of insulin designed to enhance gut adaptation and rehabilitation in premature infants and children. Its key clinical programs include NTRA-2112, which aims to reduce enteral nutrition intolerance, promote growth velocity and weight gain, and decrease the length of stay in neonatal intensive care units. Another significant product, NTRA-9620, targets short bowel syndrome by improving bowel adaptation post-resection, facilitating enteral nutrition, and minimizing the reliance on parenteral nutrition. Founded in 2003, Nutrinia is committed to improving the health outcomes of vulnerable populations through innovative scientific solutions.

Alector, Inc. is a clinical-stage biopharmaceutical company focused on developing novel therapies for neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. Founded in 2013 and headquartered in South San Francisco, California, the company utilizes advanced antibody technology and insights from neuroimmunology and human genetics to create innovative treatments. Alector’s pipeline includes several candidates, such as AL001, which is undergoing phase II clinical trials for frontotemporal dementia, and AL101, currently in phase I trials for Alzheimer's and Parkinson's diseases. Additionally, AL002 and AL003 are in phase 1b trials for Alzheimer’s disease. The company is actively engaged in research and development, with a total of ten programs at various stages. Alector has formed a strategic collaboration with Adimab, LLC to enhance its antibody research and development capabilities, aiming to efficiently generate and validate antibody drugs that target key disease-related mechanisms.

Guardant Health is a precision oncology company specializing in blood tests and analytics. It provides liquid biopsy tests like Guardant360 for advanced cancer detection, GuardantOMNI for broader gene panels, LUNAR-1 for minimal residual disease detection, and LUNAR-2 for early cancer detection. The company also offers development services to biopharmaceutical companies.

Aduro Biotech is a clinical-stage biopharmaceutical company focused on developing immunotherapies to harness the body's natural immune system for treating challenging diseases. Its pipeline includes ADU-S100, in Phase I/II trials for various solid tumors and head & neck cancer, and BION-1301, a monoclonal antibody in Phase I trial for IgA nephropathy.

Ascendis Pharma is a biopharmaceutical company that uses its TransCon prodrug technology platform to create long-acting therapies across endocrinology and oncology. The company's TransCon growth hormone targets growth hormone deficiency in children and has completed Phase III development; TransCon PTH is in Phase II for hypoparathyroidism, and TransCon CNP is in Phase II for achondroplasia; it is pursuing preclinical oncology programs and evaluating systemic and localized delivery; the platform enables control of exposure via TransCon carrier and linker to determine dosing frequency, with prodrugs releasing the active drug in its native form. Ascendis collaborates with Sanofi to co-develop TransCon technologies for diabetes. The company was founded in 2006 and is headquartered in Hellerup, Denmark.

Sonendo is a commercial-stage medical technology company that develops dental devices and software to save teeth. It markets the GentleWave System, a root canal therapy platform that cleans and disinfects the microscopic spaces within teeth without removing tooth structure, improving clinical outcomes and practice efficiency. The system includes a console and accessories and integrates with TDO Software, its endodontic practice management software that unifies imaging, practice management, referral reporting, CBCT imaging, and built-in communication with the GentleWave System. Founded in 2006 and based in Laguna Hills, California, Sonendo operates with two business segments: Product, comprising the GentleWave console and instruments, and Software, providing practice management licenses. The company aims to transform dentistry by saving teeth through sound science.

Otonomy, Inc. is a biopharmaceutical company based in San Diego, California, specializing in the development and commercialization of therapeutics for ear-related diseases and disorders. The company offers OTIPRIO, a ciprofloxacin otic suspension designed for use during tympanostomy tube placement surgery in pediatric patients. Otonomy is advancing several product candidates, including OTIVIDEX, a sustained-exposure formulation of dexamethasone for treating Ménière’s disease; OTO-313, aimed at treating tinnitus; and OTO-413, which targets cochlear synaptopathy and speech-in-noise hearing difficulties. Additionally, the company is developing OTO-510, an otoprotectant intended to prevent cisplatin-induced hearing loss, and OTO-6XX, which aims to induce hair cell regeneration for severe hearing loss. Otonomy leverages a proprietary formulation platform that allows for sustained drug exposure from a single administration, positioning itself as a leader in localized drug delivery for otic disorders. Founded in 2008, Otonomy focuses its operations primarily in the United States.

Sierra Oncology, Inc. is a clinical-stage biopharmaceutical company dedicated to researching, developing, and commercializing targeted therapies for hematology and oncology patients. Founded in 2003 and headquartered in Vancouver, Canada, the company focuses on delivering innovative treatments for rare forms of cancer. Its lead drug candidate, momelotinib, is a selective inhibitor of JAK1, JAK2, and ACVR1, which has been evaluated in two completed Phase 3 trials for myelofibrosis. In addition, Sierra is advancing SRA737, an inhibitor of Checkpoint kinase 1 currently undergoing Phase 1/2 clinical trials, and SRA141, an inhibitor of cell division cycle 7 kinase in preclinical development. Through its scientific expertise and evidence-based approach, Sierra Oncology aims to transform cancer treatment paradigms and improve patient outcomes.

Practice Fusion, Inc. is a cloud-based electronic health records (EHR) company based in San Francisco, California, founded in 2005. The company specializes in providing a comprehensive practice management software platform that facilitates various healthcare functions, including charting, scheduling, billing, e-prescribing, lab integrations, and secure messaging. By connecting doctors, patients, and data, Practice Fusion aims to enhance healthcare delivery and improve patient outcomes. Its platform serves a diverse range of users, including independent medical practices, large medical groups, and community clinics, as well as life science partners. Additionally, Practice Fusion Insight offers a healthcare database to support medical professionals in their practice. As of February 2018, Practice Fusion operates as a subsidiary of Allscripts Healthcare Solutions, Inc.

Affimed NV is a clinical-stage biopharmaceutical company focused on developing innovative cancer immunotherapies. With nearly two decades of expertise in innate immunity, Affimed seeks to leverage the innate immune system to enhance cancer treatment outcomes. The company specializes in discovering and advancing targeted therapies through its unique approach of using innate cell engagers, which aim to address the limitations of existing immuno-oncology therapies. In addition to its core research and development efforts, Affimed also generates revenue by providing research and development services to third parties, utilizing both its own and externally licensed intellectual property.

Aragon Pharmaceuticals is a discovery-stage small molecule company dedicated to developing therapeutics for hormone-resistant cancers, specifically targeting prostate and breast cancer. The company specializes in anti-endocrine therapies that leverage nuclear receptor biology, medicinal chemistry, and drug discovery methodologies. Aragon aims to identify and create selective androgen receptor degraders for prostate cancer and selective estrogen receptor degraders for estrogen-sensitive breast cancer, addressing the need for effective treatments in these challenging areas of oncology.

Roka Bioscience specializes in the development of rapid and accurate molecular assays and instrument systems aimed at the food safety industry. The company's latest innovation, the Atlas System, introduces advanced molecular rapid pathogen testing, which enhances laboratory efficiency through automation and user-friendly design. By focusing on innovative testing solutions, Roka Bioscience aims to assist food manufacturers in minimizing risks, safeguarding their brands, and addressing the growing demands for testing in the sector.

Ambit Biosciences is a privately-held biopharmaceutical company that specializes in the discovery and development of small molecule kinase inhibitors aimed at treating cancer and inflammatory diseases. The company's lead compound, AC220, is a selective and orally bioavailable inhibitor of FMS-like tyrosine kinase-3 (FLT3), currently undergoing clinical trials for patients with relapsed or refractory acute myeloid leukemia (AML). Ambit is collaborating with Astellas Pharma Inc. to jointly develop and commercialize FLT3 kinase inhibitors across various therapeutic areas. In addition to AC220, Ambit's clinical pipeline features AC480, a pan-HER inhibitor, and AC430, an oral inhibitor of JAK2. Furthermore, the company has several preclinical candidates, including CEP-32496, a BRAF inhibitor that is licensed to Cephalon. Through its innovative approach, Ambit aims to enhance treatment outcomes for cancer patients.

Adimab LLC is a biotechnology company specializing in the discovery, development, and optimization of human monoclonal and bispecific antibodies. Founded in 2007 and based in Lebanon, New Hampshire, Adimab utilizes a yeast-based platform to create therapeutic antibodies, including IgG and CD3-based bispecific antibodies. The company is recognized for its ability to deliver diverse and high-quality antibody panels that adhere to stringent standards for affinity, epitope coverage, and species cross-reactivity. This capability allows Adimab to support its partners in rapidly expanding their biologics pipelines through various technology access arrangements. The company's work primarily targets the treatment of cancer, autoimmune disorders, and infectious diseases.

Complete Genomics is a developer of advanced DNA sequencing technology focused on human genome sequencing and analysis. The company offers a comprehensive genomics analysis platform that integrates its proprietary sequencing technology with informatics and data management software. This combination allows Complete Genomics to deliver high-quality, affordable DNA sequencing services that facilitate large-scale research into the genetic mechanisms underlying drug responses and complex diseases. By providing ready-to-use genomic data, Complete Genomics aims to enhance the capabilities of researchers in the field of genomics and contribute to advancements in personalized medicine.

MacroGenics is a biopharmaceutical company focused on discovering and developing antibody-based therapeutics for cancer treatment. Its pipeline includes Margetuximab targeting HER2-expressing tumors, Flotetuzumab for acute myeloid leukemia, and other immuno-oncology product candidates such as MGA012, MGD013, MGD019, and Enoblituzumab. The company also develops combination therapies like MGD009 with MGA012, and antibody drug conjugates like MGC018 targeting B7-H3.

Biolex Therapeutics is a clinical-stage biopharmaceutical company focused on developing therapeutic proteins and monoclonal antibodies using its patented LEX System. This innovative technology genetically transforms the aquatic plant Lemna to facilitate the production of biologic product candidates that are challenging to manufacture. Biolex's primary product is designed to address the needs of patients afflicted with Hepatitis C, aiming to improve treatment outcomes through enhanced efficacy and potency of its therapeutic offerings.

Glaukos is an ophthalmic medical technology company focused on developing and commercializing products and procedures to transform the treatment of glaucoma, corneal disorders, and retinal diseases. It pioneered Micro-Invasive Glaucoma Surgery (MIGS) to provide less invasive options for glaucoma management, launching its first MIGS device, iStent, in the United States in 2012. The company is building a platform of injectable micro-scale therapies designed to address the full range of glaucoma disease states and progression. In addition to MIGS, Glaukos is advancing dropless therapies and long-duration intracameral drug delivery with iDose TR, and markets a proprietary therapy for the treatment of keratoconus. Through these approaches, Glaukos aims to improve patient outcomes and reduce treatment burden by offering durable, minimally invasive solutions for eye diseases.

Ambit Biosciences is a privately-held biopharmaceutical company that specializes in the discovery and development of small molecule kinase inhibitors aimed at treating cancer and inflammatory diseases. The company's lead compound, AC220, is a selective and orally bioavailable inhibitor of FMS-like tyrosine kinase-3 (FLT3), currently undergoing clinical trials for patients with relapsed or refractory acute myeloid leukemia (AML). Ambit is collaborating with Astellas Pharma Inc. to jointly develop and commercialize FLT3 kinase inhibitors across various therapeutic areas. In addition to AC220, Ambit's clinical pipeline features AC480, a pan-HER inhibitor, and AC430, an oral inhibitor of JAK2. Furthermore, the company has several preclinical candidates, including CEP-32496, a BRAF inhibitor that is licensed to Cephalon. Through its innovative approach, Ambit aims to enhance treatment outcomes for cancer patients.

Agensys is a biotechnology company focused on the research and development of therapeutic human monoclonal antibodies and antibody-drug conjugates specifically aimed at treating various types of cancer. Founded in 1997 and based in Santa Monica, California, Agensys develops innovative products targeting tumors, including those associated with prostate, pancreatic, bladder, kidney, lung, and colon cancers. The company is dedicated to providing effective treatment options for patients battling these cancers. In 2007, Agensys became a subsidiary of Astellas Pharma US, Inc., further enhancing its capabilities in the oncology therapeutic space.

Singulex develops and commercializes single molecule counting technology for clinical diagnostics and scientific discovery. Its flagship product, the Sgx Clarity System, enables ultra-sensitive detection of biomarkers down to femtograms/mL, aiding in cardiovascular health management and personalized wellness programs. Singulex serves pharmaceutical R&D labs, clinical research organizations, and academic institutions worldwide.

ChemoCentryx is a biopharmaceutical company developing new medications for inflammatory disorders, autoimmune diseases, and cancer. It focuses on orally-administered small molecule therapeutics targeting chemokine receptors.

Adiana, Inc. is a company based in Redwood City, California, founded in 1997, that focuses on the development and testing of transcervical sterilization systems for permanent birth control. The company's main product, Complete TCS, comprises a radiofrequency generator, delivery catheter, and implantable matrix, designed to occlude the fallopian tubes and prevent pregnancy. Adiana aims to provide a novel, non-incisional alternative to traditional tubal ligation, offering women a solution that minimizes the side effects and complications associated with other contraceptive methods. As of 2007, Adiana operates as a subsidiary of CYTYC Corp.

Emphasys Medical is a medical device company based in Redwood City, California, specializing in the development of therapeutic devices for the treatment of emphysema and other chronic obstructive pulmonary diseases (COPD). Founded in 2000, the company focuses on minimally invasive therapies that aim to alleviate the symptoms associated with these respiratory conditions. Its flagship product, the Zephyr Endobronchial Valve system, is designed to block airflow through damaged lung tissue, facilitating healing and improving lung function. By offering innovative solutions for patients with emphysema, Emphasys Medical seeks to enhance the quality of life for individuals suffering from debilitating breathing disorders.

Aryx Therapeutics is a biopharmaceutical company that specializes in the development of innovative oral therapies aimed at chronic diseases. The company leverages its expertise in retrometabolic drug design to create product candidates that address and eliminate safety concerns associated with existing, commercially successful medications. By focusing on improving the safety profiles of these therapies, Aryx Therapeutics seeks to enhance patient outcomes and provide better treatment options in the pharmaceutical market. The company's commitment to advancing drug safety is supported by a strong portfolio of intellectual property.

Auxilium Pharmaceuticals, founded in 1999, specializes in the development and marketing of pharmaceutical products primarily aimed at urology and sexual health disorders. The company is committed to improving patient outcomes through the identification, development, and commercialization of innovative specialty biopharmaceuticals. Over the years, Auxilium has expanded its mission to address a broader range of unmet medical needs, focusing on creating novel treatment options that enhance the quality of life for patients dealing with various health challenges.

CryoCor is a medical technology company based in San Diego that develops cryogenic solutions to treat cardiac rhythm disorders. Its flagship system, the CryoCor Cardiac Cryoablation System, is a catheter-based, minimally invasive device that creates electrically isolating lesions with cold energy to treat arrhythmias such as atrial fibrillation. The system comprises a cryoablation catheter connected to an articulating arm on a refrigeration console and can be used with introducer sheaths to facilitate catheter placement. By cooling tissue to about -90°C, it blocks abnormal electrical signals and helps restore normal heart rhythm. The technology is marketed for use in Europe, where it has been available since 2002 and is deployed at multiple medical centers under the management of the company’s European operations.

Molecular Staging Inc., a life sciences tool company, specializes in developing technologies for the detection and measurement of proteins and nucleic acids. Its offerings include protein microarrays for proteomics research, whole-genome amplification tools to overcome limited DNA sample constraints, and multiplexed diagnostics for enhanced disease detection. These products cater to applications in genomics, pharmacogenomics, and diagnostics.