OrbiMed

OrbiMed Advisors LLC is a healthcare-focused investment firm founded in 1989, headquartered in New York City, with additional offices in various global locations. The firm manages approximately $5 billion in assets and specializes in private equity and venture capital investments across the healthcare sector, including pharmaceuticals, biotechnology, medical devices, and healthcare services. OrbiMed invests in companies at various stages, from early startups to established multinationals, and typically seeks to take majority stakes in its private equity investments. The firm employs fundamental analysis to guide its investment decisions and offers a range of financial services, including debt financing and structured capital, to both public and private healthcare companies. OrbiMed's investment strategy encompasses a broad spectrum of healthcare-related opportunities, targeting investments globally, primarily in North America, Europe, and Asia.
601 Lexington Avenue (at 53rd Street), 54th Floor New York, NY 10022-4629
1700 Owens Street Suite 540 San Francisco, CA 94158
Suite F 27, Grand Hyatt Plaza Santacruz (East) Mumbai, 400055, India
89 Medinat HaYehudim St Building E, 11th Floor Herzliya 4614001, Israel
Unit 4706, Raffles City Shanghai Office Tower 268 Xizang Middle Road Shanghai 200001, P.R. China
12/F International Commerce Centre 1 Austin Road West, Unit 01 Kowloon, Hong Kong

Roy Amariglio Ph.D

Principal

Mona Ashiya

Partner, Private Equity

Sven H. Borho

Partner

Evan Caplan

Principal

Clay DeMarcus

Vice President

Michael Eggenberg

Managing Director

Lars Enstrom

Managing Director

Robert Glassman

Venture Partner

Joshua Golomb

Partner, Public Equity

Carl L. Gordon

Managing Partner

Rishi Gupta

Partner

Geoffrey C. Hsu

Partner

Madeline Huber

Senior Associate

Alexandria Huynh

Analyst

Mark R. Jelley

Partner

Kip Kitur

Vice President

Jonathan Lee

Partner

Yifu Liu

Managing Director, Asia

Leo Ma

Senior Associate

Jonathan Mandelbaum

Vice President, Private Equity

John McGrath

Venture Partner

Anat Naschitz

Venture Partner

Carter Neild

Managing Partner

Anat Nursella

Venture Partner

Valerie Odegard

Venture Partner

Topher Orr

Partner

Jeff Peters

Venture Partner

Trevor Polischuk

Partner, Public Equity

Matthew S. Rizzo

General Partner

William F. Sawyer

Partner

Natasha Shervani

Vice President

Jonathan Silverstein

Co-Head of Private Equity and Managing Partner

Vivek Sivathanu

Vice President

Charles Steinman

Analyst

C. Scotland Stevens

Public Equity Partner

Jim Sullivan

Venture Partner

Clive Wang

Director, Asia

David Wang

Partner

Iris Wang

Partner

Steven Wang

Partner

Dimitrios Weedon

Managing Director

Matthew L. Wotiz

Principal

Stella Xing

Managing Director

Diyong Xu

Principal, Private Equity / Venture Capital

Nate Yee

Principal

Jessica Zhang

Senior Associate

Daniel Zhou

Managing Director

Mishael Zohar

Senior Associate

Guowei Wang Ph.D

Senior Managing Director, Asia and Partner

Carl Gordon Ph.D

Managing Partner and Head of Global Private Equity

Steven Wang Ph.D

Partner

Past deals in Dental

Delfi Diagnostics

Series B in 2022
Delfi Diagnostics, Inc. is a biotechnology company based in Baltimore, Maryland, that focuses on the early detection of cancer through non-invasive blood tests. Founded in 2018, the company utilizes advanced technologies such as artificial intelligence and genome sequencing to identify unique patterns of DNA fragmentation in patients' blood. By leveraging machine learning, Delfi develops innovative testing systems aimed at recognizing cancer-associated cell-free DNA fragments, thereby enabling healthcare professionals to detect cancer at its most treatable stage. This approach facilitates timely and effective treatment options, ultimately aiming to improve patient outcomes and recovery speed.

Miaoshou Doctor

Series F in 2021
Miaoshou Doctor is a healthcare service platform founded in 2015 by Tao He and Daoliang Han, based in Beijing. The platform facilitates communication between healthcare professionals and patients, focusing on the management of post-diagnosis outcomes. It enables doctors to actively follow up with patients through additional counseling and prescriptions, enhancing the overall patient care experience. By providing tools for effective interaction, Miaoshou Doctor aims to improve health management for both patients and doctors.

Arrail Dental Clinic

Series E in 2021
Arrail Dental Clinic, founded in 1998 and based in Beijing, China, specializes in a comprehensive range of oral health care services. The clinic offers treatments in various areas including endodontics, general dentistry, implants, orthodontics, pediatric dentistry, prosthodontics, and periodontics. Additional services encompass toothache treatment, restoration, tooth whitening, elderly teeth care, and hygiene. With thirty branches established in major cities such as Beijing, Shanghai, Shenzhen, Guangzhou, Xiamen, Hangzhou, and Tianjin, Arrail Dental Clinic caters to both domestic and international clients. The clinic also facilitates online appointment services, enhancing accessibility for patients.

Miaoshou Doctor

Series E in 2021
Miaoshou Doctor is a healthcare service platform founded in 2015 by Tao He and Daoliang Han, based in Beijing. The platform facilitates communication between healthcare professionals and patients, focusing on the management of post-diagnosis outcomes. It enables doctors to actively follow up with patients through additional counseling and prescriptions, enhancing the overall patient care experience. By providing tools for effective interaction, Miaoshou Doctor aims to improve health management for both patients and doctors.

Delfi Diagnostics

Series A in 2021
Delfi Diagnostics, Inc. is a biotechnology company based in Baltimore, Maryland, that focuses on the early detection of cancer through non-invasive blood tests. Founded in 2018, the company utilizes advanced technologies such as artificial intelligence and genome sequencing to identify unique patterns of DNA fragmentation in patients' blood. By leveraging machine learning, Delfi develops innovative testing systems aimed at recognizing cancer-associated cell-free DNA fragments, thereby enabling healthcare professionals to detect cancer at its most treatable stage. This approach facilitates timely and effective treatment options, ultimately aiming to improve patient outcomes and recovery speed.

Ruipeng Pet Hospital

Venture Round in 2020
Ruipeng Pet Hospital, located in Shenzhen, specializes in a comprehensive range of pet care services. The hospital provides medical and beauty care for pets, including healthcare, foster care, bathing, SPA treatments, grooming, food, and entertainment. By offering both digital and clinical services, Ruipeng aims to ensure that pet owners can access high-quality care for their animals efficiently. The organization also includes online shopping options to further support pet owners in meeting their pets' needs.

Sonendo

Private Equity Round in 2020
Sonendo, Inc. is a medical technology company that focuses on advancing dental care through innovative devices for root canal therapy. Based in Laguna Hills, California, Sonendo has developed the GentleWave® System, which enhances the cleaning and disinfection of tooth canals, improving clinical outcomes and efficiency compared to traditional methods. The company operates primarily through two segments: the Product segment, which includes sales of the GentleWave System and its related instruments, and the Software segment, which encompasses TDO® Software—widely recognized as a leading practice management solution for endodontics. Since its incorporation in 2006, Sonendo has aimed to transform dentistry by promoting effective treatments that preserve tooth structure and enhance patient care.

Sonendo

Private Equity Round in 2017
Sonendo, Inc. is a medical technology company that focuses on advancing dental care through innovative devices for root canal therapy. Based in Laguna Hills, California, Sonendo has developed the GentleWave® System, which enhances the cleaning and disinfection of tooth canals, improving clinical outcomes and efficiency compared to traditional methods. The company operates primarily through two segments: the Product segment, which includes sales of the GentleWave System and its related instruments, and the Software segment, which encompasses TDO® Software—widely recognized as a leading practice management solution for endodontics. Since its incorporation in 2006, Sonendo has aimed to transform dentistry by promoting effective treatments that preserve tooth structure and enhance patient care.

Sonendo

Series E in 2016
Sonendo, Inc. is a medical technology company that focuses on advancing dental care through innovative devices for root canal therapy. Based in Laguna Hills, California, Sonendo has developed the GentleWave® System, which enhances the cleaning and disinfection of tooth canals, improving clinical outcomes and efficiency compared to traditional methods. The company operates primarily through two segments: the Product segment, which includes sales of the GentleWave System and its related instruments, and the Software segment, which encompasses TDO® Software—widely recognized as a leading practice management solution for endodontics. Since its incorporation in 2006, Sonendo has aimed to transform dentistry by promoting effective treatments that preserve tooth structure and enhance patient care.

Laxmi Dental

Venture Round in 2015
Laxmi Dental Export Private Limited operates a dental laboratory that specializes in providing dental products and services. The company manufactures prosthodontics and dental cosmetic products, such as porcelain fused to metals, restoration dental materials, ceramic restorations, implant systems, composites, and cast partial dentures. It serves laboratories and dentists worldwide. The company was incorporated in 2004 and is based in Mumbai, India.

Sonendo

Series D in 2014
Sonendo, Inc. is a medical technology company that focuses on advancing dental care through innovative devices for root canal therapy. Based in Laguna Hills, California, Sonendo has developed the GentleWave® System, which enhances the cleaning and disinfection of tooth canals, improving clinical outcomes and efficiency compared to traditional methods. The company operates primarily through two segments: the Product segment, which includes sales of the GentleWave System and its related instruments, and the Software segment, which encompasses TDO® Software—widely recognized as a leading practice management solution for endodontics. Since its incorporation in 2006, Sonendo has aimed to transform dentistry by promoting effective treatments that preserve tooth structure and enhance patient care.

Domain Surgical

Series C in 2014
Domain Surgical is a medical device company that is creating energy-based surgical products for precise soft tissue cutting and coagulation. It creates energy-based equipment used in specialty surgical procedures. Its patent-pending technology produces surface-only tissue effects with energy that does not pass through the patient designed with the surgical staff in mind, for simple user-interface and training. The company manufactures and markets the FMwand Ferromagnetic Surgical System, a hemostatic dissection device that uses pure thermal energy to cut and coagulate soft tissue, without passing an electrical current through the patient. The FMwand imparts as little as 1/10th the amount of thermal injury compared to traditional electrosurgery devices. The FMwand provides fine dissection with a layer-by-layer precision that is unmatched by existing surgical technology.

Sonendo

Series C in 2013
Sonendo, Inc. is a medical technology company that focuses on advancing dental care through innovative devices for root canal therapy. Based in Laguna Hills, California, Sonendo has developed the GentleWave® System, which enhances the cleaning and disinfection of tooth canals, improving clinical outcomes and efficiency compared to traditional methods. The company operates primarily through two segments: the Product segment, which includes sales of the GentleWave System and its related instruments, and the Software segment, which encompasses TDO® Software—widely recognized as a leading practice management solution for endodontics. Since its incorporation in 2006, Sonendo has aimed to transform dentistry by promoting effective treatments that preserve tooth structure and enhance patient care.

Sonendo

Series C in 2012
Sonendo, Inc. is a medical technology company that focuses on advancing dental care through innovative devices for root canal therapy. Based in Laguna Hills, California, Sonendo has developed the GentleWave® System, which enhances the cleaning and disinfection of tooth canals, improving clinical outcomes and efficiency compared to traditional methods. The company operates primarily through two segments: the Product segment, which includes sales of the GentleWave System and its related instruments, and the Software segment, which encompasses TDO® Software—widely recognized as a leading practice management solution for endodontics. Since its incorporation in 2006, Sonendo has aimed to transform dentistry by promoting effective treatments that preserve tooth structure and enhance patient care.

DFine

Venture Round in 2011
DFINE Inc. develops minimally invasive therapeutic devices that are used to treat pathologies of the vertebrae, metastatic spinal tumors, and vertebral compression fractures. It offers STAR, a tumor ablation system for palliative treatment in spinal procedures by ablation of metastatic malignant lesions in a vertebral body; vertebral augmentation systems for percutaneous delivery of bone cement and the treatment of pathological fractures; and vertebroplasty systems. The company was founded in 2004 and is based in San Jose, California. As of July 6, 2016, DFINE Inc. operates as a subsidiary of Merit Medical Systems, Inc..

DFine

Venture Round in 2010
DFINE Inc. develops minimally invasive therapeutic devices that are used to treat pathologies of the vertebrae, metastatic spinal tumors, and vertebral compression fractures. It offers STAR, a tumor ablation system for palliative treatment in spinal procedures by ablation of metastatic malignant lesions in a vertebral body; vertebral augmentation systems for percutaneous delivery of bone cement and the treatment of pathological fractures; and vertebroplasty systems. The company was founded in 2004 and is based in San Jose, California. As of July 6, 2016, DFINE Inc. operates as a subsidiary of Merit Medical Systems, Inc..

Angelalign

Series A in 2010
Angelalign Technology Inc is an investment holding company. It is principally engaged in clear aligner treatment solutions including treatment planning services, manufacturing, and marketing of clear aligners. The company provides dental professionals with self-developed digital orthodontics solutions. The company's Angelalign clear aligner system facilitates dental professionals throughout the entire clear aligner treatment process, including digitally-assisted case assessment support and treatment planning services, provide dental professionals with digitally-assisted case assessment support and treatment planning services, and helps dental professionals design, reviewmore

Peninsula Pharmaceuticals

Series C in 2004
Peninsula Pharmaceuticals, Inc. is a specialty pharmaceutical company dedicated to the licensing, development, and commercialization of anti-infective therapies aimed at treating life-threatening infections in North America and Europe. The company's primary focus is on its lead product candidate, doripenem, a broad-spectrum antibiotic classified as a carbapenem. Currently, Peninsula is conducting six Phase III clinical trials for doripenem, which has also received Fast Track designation from the U.S. Food and Drug Administration for the treatment of nosocomial pneumonia, including ventilator-associated pneumonia. The company was acquired by Johnson & Johnson, a global leader in healthcare products and services. As a privately held biopharmaceutical entity, Peninsula Pharmaceuticals concentrates on advancing antibiotics to address critical infection-related health challenges.
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