New Enterprise Associates

Glacier, founded in 2019 and based in San Francisco, California, has developed the first affordable, high-performing, and space-efficient AI-enabled robot designed specifically for recycling. The company aims to transform the recycling industry by utilizing artificial intelligence-powered sensors and robotics to automate the sorting of recyclable materials. This innovative approach allows recycling facilities to enhance their operational efficiency, improve sorting accuracy, and ultimately increase profitability. By integrating advanced technology into the recycling process, Glacier is positioned to significantly impact how recycling facilities manage and process materials.

Instabase, Inc. is a technology company that develops a platform aimed at automating document processing workflows and analyzing unstructured data. Founded in 2015 and based in San Francisco, California, the company provides a range of services, including optical character recognition, data classification and extraction, and natural language processing. Its platform is designed to help organizations in various sectors, such as insurance, finance, and healthcare, streamline operations and improve decision-making. By enabling businesses to embed artificial intelligence into their systems and processes, Instabase facilitates the development of applications that address significant operational challenges, particularly in the realm of intelligent document processing.

SafeBase, Inc. is a company that specializes in developing cloud-based security software aimed at helping organizations establish effective security programs and enhance their credibility with customers. Founded in 2020 and based in San Francisco, California, SafeBase offers a smart trust center platform that facilitates the sharing of security posture and automates access to sensitive documents. Its key features include SafeBase Inspected, which provides a web badge linked to a custom security status page, as well as custom security checklists and continuous monitoring of security systems. The software also aids companies in configuring their security policies, enabling them to adopt robust security practices efficiently.

Xaira Therapeutics is an integrated biotechnology company focused on revolutionizing drug discovery and development through the application of artificial intelligence. Headquartered in the San Francisco Bay Area, Xaira combines expertise in machine learning, extensive biological and clinical data generation, and robust therapeutic product development. By harnessing advanced AI techniques, the company aims to enhance the understanding of biological processes and improve the effectiveness of therapies. Xaira's approach encompasses all stages of drug discovery, striving to transform how diseases are treated and enabling clients to deliver innovative therapeutic solutions.

Lily AI is a developer of an e-commerce product discovery platform that enhances the sales capabilities of brands and retailers. The platform integrates customer-centric product attributes into various components of the e-commerce ecosystem, including site search engines, recommendation systems, and SEO/SEM functionalities. By improving on-site search and personalized product discovery, Lily AI supports retailers in the fashion, home, and beauty sectors, leading to significant increases in traffic, conversion rates, revenue, and brand loyalty. Headquartered in Mountain View, California, the company is backed by venture capital.

Regulus Therapeutics Inc. is a clinical stage biopharmaceutical company based in San Diego, California, specializing in the discovery and development of therapies that target microRNAs for various diseases. The company is advancing its lead product candidates, RG-012 and RGLS4326, which are in Phase II and Phase Ib clinical trials, respectively. RG-012 targets miR-21 for the treatment of Alport syndrome, a severe kidney disease, while RGLS4326 targets miR-17 for autosomal dominant polycystic kidney disease. In addition to these candidates, Regulus is developing a pipeline of preclinical drug products, including RGLS5579, aimed at inhibiting miR-10b, as well as programs targeting hepatitis B virus and non-alcoholic steatohepatitis. Founded in 2007, Regulus Therapeutics is at the forefront of leveraging the therapeutic potential of microRNA, a significant scientific breakthrough in recent years.

Glacier, founded in 2019 and based in San Francisco, California, has developed the first affordable, high-performing, and space-efficient AI-enabled robot designed specifically for recycling. The company aims to transform the recycling industry by utilizing artificial intelligence-powered sensors and robotics to automate the sorting of recyclable materials. This innovative approach allows recycling facilities to enhance their operational efficiency, improve sorting accuracy, and ultimately increase profitability. By integrating advanced technology into the recycling process, Glacier is positioned to significantly impact how recycling facilities manage and process materials.

Mojo Vision Inc. is a company based in Saratoga, California, established in 2015, that specializes in augmented reality technology. The firm is focused on developing high-performance micro-LED displays for various applications, including consumer, enterprise, and government sectors. It has created the world's smallest and densest dynamic display integrated into a smart contact lens, designed to provide users with timely information without disrupting their focus. This innovative product allows for hands-free connectivity and access to relevant information, thereby minimizing reliance on traditional mobile devices. Additionally, Mojo Vision has formed a joint development agreement with Menicon Co., Ltd. to explore smart contact lens products further, leveraging its advanced micro-LED technology and manufacturing processes to disrupt the display industry.

Gossamer Bio is a clinical-stage biopharmaceutical company based in San Diego that focuses on the discovery and development of innovative therapeutic products for unmet medical needs. Founded by former executives from Receptos, the company aims to leverage a strong in-licensing strategy and a team with extensive experience in immunology, inflammation, fibrosis, and oncology. Gossamer Bio's pipeline includes several promising candidates: Seralutinib, which targets pulmonary arterial hypertension; GB004, aimed at treating inflammatory bowel diseases such as ulcerative colitis and Crohn's disease; GB1275, designed for various oncology indications; and GB001, intended for moderate-to-severe eosinophilic asthma. Through these efforts, Gossamer Bio seeks to improve patient outcomes in critical therapeutic areas.

Instabase, Inc. is a technology company that develops a platform aimed at automating document processing workflows and analyzing unstructured data. Founded in 2015 and based in San Francisco, California, the company provides a range of services, including optical character recognition, data classification and extraction, and natural language processing. Its platform is designed to help organizations in various sectors, such as insurance, finance, and healthcare, streamline operations and improve decision-making. By enabling businesses to embed artificial intelligence into their systems and processes, Instabase facilitates the development of applications that address significant operational challenges, particularly in the realm of intelligent document processing.

Regulus Therapeutics Inc. is a clinical stage biopharmaceutical company based in San Diego, California, specializing in the discovery and development of therapies that target microRNAs for various diseases. The company is advancing its lead product candidates, RG-012 and RGLS4326, which are in Phase II and Phase Ib clinical trials, respectively. RG-012 targets miR-21 for the treatment of Alport syndrome, a severe kidney disease, while RGLS4326 targets miR-17 for autosomal dominant polycystic kidney disease. In addition to these candidates, Regulus is developing a pipeline of preclinical drug products, including RGLS5579, aimed at inhibiting miR-10b, as well as programs targeting hepatitis B virus and non-alcoholic steatohepatitis. Founded in 2007, Regulus Therapeutics is at the forefront of leveraging the therapeutic potential of microRNA, a significant scientific breakthrough in recent years.

Mojo Vision Inc. is a company based in Saratoga, California, established in 2015, that specializes in augmented reality technology. The firm is focused on developing high-performance micro-LED displays for various applications, including consumer, enterprise, and government sectors. It has created the world's smallest and densest dynamic display integrated into a smart contact lens, designed to provide users with timely information without disrupting their focus. This innovative product allows for hands-free connectivity and access to relevant information, thereby minimizing reliance on traditional mobile devices. Additionally, Mojo Vision has formed a joint development agreement with Menicon Co., Ltd. to explore smart contact lens products further, leveraging its advanced micro-LED technology and manufacturing processes to disrupt the display industry.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

Founded in 2021 as a subsidiary of EST Media Holdings, OP3N is the global Web3 superapp that serves as a one-stop-shop for all communication, connection and commerce with on-chain interactions in a simple unified interface. With a mission to create a more frictionless, decentralized and democratized creator economy on a global scale, OP3N consolidates the tools needed to mint, share and engage with digital goods and digital tokens into one vertical stack. OP3N’s leadership team leverages its cross-industry expertise from the entertainment, gaming and tech ecosystems, to lay the foundations for a new era of community-driven, inclusive entertainment while bringing everyone together on a journey into Web3. OP3N is co-led by media executive, artist, and serial entrepreneur Jaeson Ma, who has a successful track record launching companies including EST Studios, Stampede Ventures, East West Ventures, and 88rising, and who’s raised capital and advised on transactions totaling over $1 billion; and Eric Tu, an award-winning development executive who’s worked with major brands including Nike, Beats by Dre and Google, and as an Executive Producer with Bjork, Radiohead, Kendrick Lamar and more. The company is headquartered in Los Angeles. For more information, please visit: https://op3n.world. OP3N’s portfolio of projects includes a partnership with Tokyo fashion label AMBUSH; an intergalactic children’s book from Grimes; a partnership with entertainment icon Simon Fuller to produce an innovative musical film with the global pop group Now United; and the “Maybe You’re the Problem” music video from the singer-songwriter Ava Max, directed by the celebrated music video director Joseph Kahn.

Fabric8Labs, Inc., founded in 2015 and based in La Jolla, California, specializes in non-thermal metal 3D printing technology. The company has developed a distinctive process that combines stereo-lithography and electro-deposition, providing an innovative alternative to traditional powder bed fusion methods. This technology eliminates the need for metal powders, vacuum chambers, and lasers, which significantly reduces manufacturing costs. Moreover, Fabric8Labs' approach enhances material quality and simplifies the additive manufacturing process by utilizing cartridges that ensure safety during production and facilitate easy disposal of used salt cartridges. Through these advancements, Fabric8Labs aims to revolutionize the landscape of metal 3D printing.

Crowdbotics Corporation is a software development company that provides an application builder platform aimed at streamlining the creation and deployment of web and mobile applications. Founded in 2016 and based in Richmond, California, Crowdbotics enables product managers and developers to transform ideas into functional code by utilizing a comprehensive library of millions of production-grade software components. The platform employs systematic code reuse and artificial intelligence to match specific application requirements with existing code modules, enhancing efficiency and reducing risk. Additionally, Crowdbotics offers ongoing support services, including infrastructure management, implementation, maintenance, monitoring, and security for applications throughout their lifecycle, which allows businesses to focus on achieving their objectives while minimizing development time.

SetPoint Medical is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices aimed at treating chronic autoimmune diseases. The company is creating a platform that stimulates the vagus nerve to activate the body's natural inflammatory reflex, leading to a systemic immune-restorative effect. This innovative approach offers an alternative treatment option for conditions such as rheumatoid arthritis and inflammatory bowel disease, with the potential for reduced risks and costs compared to traditional drug therapies. SetPoint Medical, originally known as Innovative Metabolics Inc. until its name change in 2008, aims to provide patients and healthcare providers with effective solutions for managing debilitating inflammatory diseases.

Minerva Surgical Inc. is a medical technology company based in Redwood City, California, specializing in women's healthcare. Founded in 2008, the company develops, manufactures, and commercializes minimally invasive solutions aimed at addressing the unique uterine health needs of women. Its flagship product, The Minerva Endometrial Ablation System, provides a treatment option for abnormal uterine bleeding, a common issue among women. Minerva Surgical offers a range of alternatives to hysterectomy, designed to tackle the leading causes of abnormal uterine bleeding while preserving the uterus and minimizing the drawbacks associated with traditional treatment methods. The company's solutions are suitable for various medical settings, reflecting its commitment to improving women's health outcomes.

Gladly is a customer service platform that enables B2C companies to focus on people talking to people throughout a lifetime of naturally productive conversations. With Gladly, customers are at the center and brands can communicate with their customers seamlessly across any channel from voice, email, messaging, chat, and social media. Agents are empowered, customers feel known, and companies build love and loyalty through consistently positive experiences. Gladly is based in San Francisco and funded by Greylock Partners, GGV Capital, NEA, and JetBlue Ventures.

Escient Pharmaceuticals is a biotechnology company based in San Diego, California, that develops and manufactures drugs targeting G protein-coupled receptors (GPCRs) for the treatment of neuro-immuno-inflammatory and autoreactive diseases. Founded in 2017, the company specializes in harnessing the therapeutic potential of specific orphan GPCRs, particularly the Mas-Related G-Protein Receptors (Mrgprs), to address various neurosensory-inflammatory disorders. Escient's innovative approach aims to provide first-in-class therapies for conditions associated with mast cell-mediated disorders and cholestatic pruritus, thereby expanding treatment options for healthcare providers and patients facing these challenging diseases.

Dandelion Energy, Inc., founded in 2017 and based in Palo Alto, California, specializes in providing affordable geothermal heating and cooling installations. The company has developed a home geothermal system that replaces traditional air conditioning and heating equipment with an efficient heat pump and safe underground pipes. This system harnesses thermal energy from the earth to regulate indoor temperatures and produce hot water, allowing homeowners to transition from conventional heating fuels to a more sustainable geothermal solution. Dandelion Energy aims to make renewable energy accessible and cost-effective for residential customers.

Swift Navigation, Inc. is a technology company specializing in precise global positioning system (GPS) solutions, founded in 2012 and based in San Francisco, California, with an additional location in Melbourne, Australia. The company develops hardware and software that provide centimeter-level accuracy through real-time kinematics (RTK) technology. Its product lineup includes the Piksi Multi GNSS Module, a versatile RTK receiver, and the Duro Ruggedized Receiver, designed for various industrial applications such as agriculture and robotics. Additionally, Swift Navigation offers the Skylark cloud corrections service and the Starling GNSS positioning engine, which caters to automotive and autonomous vehicle needs. The company's innovative solutions, characterized by their affordability and high accuracy—100 times better than standard GPS—serve multiple industries, including unmanned aerial vehicles, surveying, and space applications. Swift Navigation's commitment to making advanced positioning technology accessible is recognized by notable accolades, including mentions in Inc. and Forbes 30 Under 30 lists.

Allakos Inc. is a clinical-stage biopharmaceutical company based in Redwood City, California, founded in 2012. The company focuses on developing antibody-based therapeutics aimed at treating various conditions linked to dysregulation of the T-helper type 2 immune response, such as allergic diseases and chronic inflammation. Its lead product, antolimab (AK002), targets conditions including eosinophilic gastritis, eosinophilic gastroenteritis, chronic urticaria, indolent systemic mastocytosis, and severe allergic conjunctivitis. Additionally, Allakos is developing AK006, an antibody that targets Siglec-6, an inhibitory receptor found on mast cells. By binding to Siglec-6, AK006 is designed to enhance the receptor's natural inhibitory function, thereby reducing mast cell activation and associated inflammatory responses.

Higlobe is an international payment platform for overseas freelancers, contractors, and independent workers with U.S. business clients. Higlobe offers zero transaction fees, with the goal of eliminating all transaction fees. Founded in 2020, Higlobe is headquartered in Palo Alto, California.

Moximed, Inc. is a medical technology company based in Hayward, California, focused on developing innovative solutions for patients with knee osteoarthritis. The company offers the Atlas System, an implantable joint unloader designed to alleviate pain for individuals suffering from medial compartment knee osteoarthritis. This system operates similarly to a shock absorber, providing dynamic load reduction to minimize joint pain and enhance mobility. Moximed also features the MISHA Knee System, which offers an outpatient treatment option for patients who have not found relief through other therapies and are not suitable candidates for knee replacement surgery. By addressing the specific needs of osteoarthritis patients, Moximed aims to improve their quality of life while potentially delaying the need for more invasive surgical interventions. Founded in 2006, the company serves patients and medical professionals worldwide.

Gossamer Bio is a clinical-stage biopharmaceutical company based in San Diego that focuses on the discovery and development of innovative therapeutic products for unmet medical needs. Founded by former executives from Receptos, the company aims to leverage a strong in-licensing strategy and a team with extensive experience in immunology, inflammation, fibrosis, and oncology. Gossamer Bio's pipeline includes several promising candidates: Seralutinib, which targets pulmonary arterial hypertension; GB004, aimed at treating inflammatory bowel diseases such as ulcerative colitis and Crohn's disease; GB1275, designed for various oncology indications; and GB001, intended for moderate-to-severe eosinophilic asthma. Through these efforts, Gossamer Bio seeks to improve patient outcomes in critical therapeutic areas.

Lily AI is a developer of an e-commerce product discovery platform that enhances the sales capabilities of brands and retailers. The platform integrates customer-centric product attributes into various components of the e-commerce ecosystem, including site search engines, recommendation systems, and SEO/SEM functionalities. By improving on-site search and personalized product discovery, Lily AI supports retailers in the fashion, home, and beauty sectors, leading to significant increases in traffic, conversion rates, revenue, and brand loyalty. Headquartered in Mountain View, California, the company is backed by venture capital.

Assembled, Inc. operates a workforce management platform designed to enhance customer support operations for modern organizations. Founded in 2018 and based in San Francisco, California, the platform automates contact forecasting and staffing calculations while generating real-time productivity reports. It enables teams to efficiently forecast support volumes and create appropriate staffing plans, replacing the need for cumbersome spreadsheets and internal tools. Assembled features an intuitive team calendar that accommodates different time zones and specializations, allowing seamless integration with tools like Google Calendar and Slack for individual user interaction. Additionally, it provides visibility into support schedules and key metrics, such as response times, across all organizational levels. By facilitating the management of inbound support queries across multiple channels, including chat, email, phone, and social media, Assembled empowers organizations to optimize their customer support services.

Mashgin Inc. specializes in manufacturing intelligent kiosks that facilitate self-checkout at various retail environments, including cafés, convenience stores, and specialty shops. Founded in 2013 and based in Mountain View, California, the company utilizes advanced computer vision and deep learning technologies to streamline the checkout process. Its kiosks can recognize and process multiple items simultaneously, allowing customers to scan products based on their visual features such as color, shape, and size. This innovative system can be deployed quickly and at a lower cost compared to other self-checkout solutions. Currently, Mashgin's technology is in use at hundreds of locations, serving tens of thousands of customers daily.

Glacier, founded in 2019 and based in San Francisco, California, has developed the first affordable, high-performing, and space-efficient AI-enabled robot designed specifically for recycling. The company aims to transform the recycling industry by utilizing artificial intelligence-powered sensors and robotics to automate the sorting of recyclable materials. This innovative approach allows recycling facilities to enhance their operational efficiency, improve sorting accuracy, and ultimately increase profitability. By integrating advanced technology into the recycling process, Glacier is positioned to significantly impact how recycling facilities manage and process materials.

Genies, Inc. is a company that specializes in avatar technology to enhance social media and messaging applications. Founded in 2011 and based in Venice, California, Genies enables users to create personalized digital avatars, which can be utilized for self-expression and interaction in various digital environments. The company has gained traction with cultural influencers and has established partnerships with major music labels, serving as the official avatar provider for artists. Genies recently expanded its offerings with an Augmented Reality (AR) Developer Kit, allowing developers to create interoperable avatar experiences. Their platform includes features for designing digital fashion and engaging in avatar-based interactive experiences. By leveraging its unique technology, Genies facilitates brand engagement and the sale of digital goods, appealing particularly to the college demographic and millennial audience. The company has raised significant investment, achieving a valuation of $1 billion.

Built Robotics Inc. develops automation technology solutions for the construction industry, focusing on transforming heavy equipment into autonomous robots. Founded in 2016 and headquartered in San Francisco, the company utilizes AI guidance systems that integrate various sensors, including GPS, cameras, and Lidar, with advanced software. These systems are retrofitted onto earthmoving equipment, allowing machines to operate fully autonomously. Built Robotics' technology is employed in building critical infrastructure such as wind farms, oil and gas pipelines, mining operations, and new housing developments. By automating repetitive tasks, the company addresses workforce shortages in sectors like solar energy, thus contributing to the transition to clean energy.

Antimatter is a cryptographic infrastructure service enabling B2B SaaS companies to provably guarantee the security of their customers' data, fundamentally solving the challenges of data security and privacy requirements without requiring any changes to code. Antimatter was founded in 2021 and is based in Oakland, California.

SafeBase, Inc. is a company that specializes in developing cloud-based security software aimed at helping organizations establish effective security programs and enhance their credibility with customers. Founded in 2020 and based in San Francisco, California, SafeBase offers a smart trust center platform that facilitates the sharing of security posture and automates access to sensitive documents. Its key features include SafeBase Inspected, which provides a web badge linked to a custom security status page, as well as custom security checklists and continuous monitoring of security systems. The software also aids companies in configuring their security policies, enabling them to adopt robust security practices efficiently.

Cohere Technologies Inc. is a technology company specializing in wireless bandwidth applications, headquartered in Santa Clara, California. Founded in 2010, the company has developed a software solution that enhances the performance of mobile and wireless networks, specifically for 4G and 5G systems. Its innovative orthogonal time frequency and space (OTFS) modulation scheme addresses limitations in current technologies, such as TDMA and OFDM, to increase bandwidth and throughput. Additionally, Cohere Technologies is recognized as a pioneer in software-enhanced networks and is working towards solutions compliant with future 6G standards. Their offerings include spectrum multiplier software that improves channel detection, estimation, and precoding, thereby enhancing user experience and meeting the growing demand for wireless connectivity.

FTX US is a bitcoin options exchange designed to assist both individual traders and institutions in trading. FTX US allows users to trade a variety of digital assets like Bitcoin, Ethereum, Solana, and Dogecoin. The company was founded by Sam Bankman-Fried and Gary Wang in 2020 and is based in San Francisco, California.

Aquabyte, Inc. specializes in developing advanced monitoring systems for the fish farming industry, employing computer vision and machine learning technologies. Founded in 2017 and headquartered in San Francisco, California, with an office in Bergen, Norway, Aquabyte's smart camera system enables real-time applications such as detecting biomass, counting sea lice, and monitoring fish appetite. The accompanying web dashboard provides continuous metrics to enhance operational efficiency. By integrating these technologies, Aquabyte aims to reduce operational costs and fish mortality while promoting sustainability in aquaculture. The company’s innovative approach seeks to address the challenges faced by fish farms, ultimately contributing to a more efficient and environmentally friendly industry.

Mojo Vision Inc. is a company based in Saratoga, California, established in 2015, that specializes in augmented reality technology. The firm is focused on developing high-performance micro-LED displays for various applications, including consumer, enterprise, and government sectors. It has created the world's smallest and densest dynamic display integrated into a smart contact lens, designed to provide users with timely information without disrupting their focus. This innovative product allows for hands-free connectivity and access to relevant information, thereby minimizing reliance on traditional mobile devices. Additionally, Mojo Vision has formed a joint development agreement with Menicon Co., Ltd. to explore smart contact lens products further, leveraging its advanced micro-LED technology and manufacturing processes to disrupt the display industry.

Sorriso Pharmaceuticals is a biotechnology company advancing a pipeline of disease-modifying antibodies for the treatment of inflammatory disease, including Crohn’s disease and ulcerative colitis. The Sorriso platform generates potent antibodies that can be delivered orally and are designed to maintain activity throughout the intestinal system. The company was founded in 2020 and is based in San Diego, California.

Anyscale, Inc. is a technology company based in Berkeley, California, founded by the creators of the open-source project Ray. It specializes in developing distributed programming platforms and tools that simplify the creation and scaling of artificial intelligence applications. Anyscale's software enables developers and machine learning engineers to effortlessly scale their applications from local environments to the cloud, eliminating the need for complex infrastructure. The company's framework allows users of varying skill levels to build and deploy compute-intensive applications efficiently, facilitating faster and more cost-effective market entry for AI products. Anyscale aims to enhance the end-to-end AI lifecycle, making it accessible for organizations to leverage AI technologies.

Regulus Therapeutics Inc. is a clinical stage biopharmaceutical company based in San Diego, California, specializing in the discovery and development of therapies that target microRNAs for various diseases. The company is advancing its lead product candidates, RG-012 and RGLS4326, which are in Phase II and Phase Ib clinical trials, respectively. RG-012 targets miR-21 for the treatment of Alport syndrome, a severe kidney disease, while RGLS4326 targets miR-17 for autosomal dominant polycystic kidney disease. In addition to these candidates, Regulus is developing a pipeline of preclinical drug products, including RGLS5579, aimed at inhibiting miR-10b, as well as programs targeting hepatitis B virus and non-alcoholic steatohepatitis. Founded in 2007, Regulus Therapeutics is at the forefront of leveraging the therapeutic potential of microRNA, a significant scientific breakthrough in recent years.

Merge provides a comprehensive platform for B2B companies to streamline their integration processes through a single application programming interface (API). Founded in 2020, the company specializes in offering Unified APIs that facilitate secure data access across various software categories, such as human resources, accounting, customer relationship management, and file storage. Merge manages the complete integration lifecycle, from a swift initial setup to ongoing maintenance and observability tools, ensuring customer satisfaction. Its services help businesses enhance their operational efficiency by reducing customer churn, accelerating product development, and lowering engineering costs. Based in San Francisco, New York City, and Berlin, Merge has garnered significant support, receiving $75 million in funding from notable investors.

Contra is a professional networking platform based in San Francisco, California, founded in 2019 by Ben Huffman and Gajus Kuizinas. The platform is designed to empower users to work independently by providing access to flexible work opportunities through a community and referral network. By showcasing work portfolios, Contra enables freelancers and independent professionals to present their skills and attract potential clients, allowing them to earn a living on their own terms. The focus on independence and flexibility distinguishes Contra in the evolving landscape of professional networking.

Stride Health, Inc. operates a health benefits platform tailored for independent workers and part-time employees in the United States. The company provides a range of affordable health coverage options, including dental plans, doctor visits, and prescription insurance. By simplifying the enrollment process, Stride Health enables users to quickly select their most cost-effective health plans while also offering assistance from personal advisors to help navigate any complexities. Founded in 2013 and based in San Francisco, California, Stride Health was previously known as Covered, Inc. The company's mission is to make health insurance more accessible and manageable for those who may not have traditional employment benefits.

Allay Therapeutics is focused on developing innovative pain management solutions aimed at improving post-surgical recovery for patients. The company utilizes a proprietary technology platform that integrates validated non-opioid analgesics with biopolymers to create dissolvable therapeutic products. These products are designed to deliver targeted pain relief at the surgical site over extended periods, significantly longer than conventional pain treatments. Allay's lead investigational product, ATX101, is currently undergoing evaluation in a Phase 2 clinical trial for total knee arthroplasty surgeries. With a team of experienced entrepreneurs, scientists, and clinicians based in the San Francisco Bay Area and Singapore, Allay Therapeutics is dedicated to transforming the approach to pain management and addressing the limitations associated with opioid use.

Rapid Robotics, Inc. is a manufacturer of automated cell robots based in San Francisco, California, established in 2019. The company focuses on providing robotic solutions for manufacturers facing labor shortages and the complexities of material handling. Its AI-driven, vision-based platform is designed to handle a variety of palletizing tasks, allowing for rapid deployment of robotic workcells that can adapt to changing business needs. By offering a Robotics-as-a-Service (RaaS) model, Rapid Robotics enables companies to enhance their operational capacity and predictability without the financial burden and complexities associated with traditional robotic ownership and maintenance. The company's technology can be implemented quickly, often within hours, and at a significantly lower cost compared to other automation systems, ultimately improving production margins through increased efficiency and quality.

Metabase is an open-source analytics and business intelligence application founded in 2014 and based in San Francisco, California. The platform enables users to create dashboards and reports, facilitating the measurement, analysis, and sharing of data to address complex business challenges. Metabase offers various professional services, including managed hosting and support, as well as assistance with implementing customized analytics solutions. This enables organizations to track data trends over time, enhancing their decision-making processes.

Merge provides a comprehensive platform for B2B companies to streamline their integration processes through a single application programming interface (API). Founded in 2020, the company specializes in offering Unified APIs that facilitate secure data access across various software categories, such as human resources, accounting, customer relationship management, and file storage. Merge manages the complete integration lifecycle, from a swift initial setup to ongoing maintenance and observability tools, ensuring customer satisfaction. Its services help businesses enhance their operational efficiency by reducing customer churn, accelerating product development, and lowering engineering costs. Based in San Francisco, New York City, and Berlin, Merge has garnered significant support, receiving $75 million in funding from notable investors.

Genies, Inc. is a company that specializes in avatar technology to enhance social media and messaging applications. Founded in 2011 and based in Venice, California, Genies enables users to create personalized digital avatars, which can be utilized for self-expression and interaction in various digital environments. The company has gained traction with cultural influencers and has established partnerships with major music labels, serving as the official avatar provider for artists. Genies recently expanded its offerings with an Augmented Reality (AR) Developer Kit, allowing developers to create interoperable avatar experiences. Their platform includes features for designing digital fashion and engaging in avatar-based interactive experiences. By leveraging its unique technology, Genies facilitates brand engagement and the sale of digital goods, appealing particularly to the college demographic and millennial audience. The company has raised significant investment, achieving a valuation of $1 billion.

TAE Technologies, Inc. is a company focused on developing clean fusion energy through advanced particle accelerator and plasma physics. Founded in 1998 and headquartered in Foothill Ranch, California, with an additional office in Rancho Santa Margarita, TAE Technologies aims to create a new source of energy derived from natural processes that generates no harmful byproducts. With over two decades of research, the company is dedicated to commercializing safe and cost-effective fusion power solutions. TAE Technologies also contributes to advancements in power management, electric mobility, and life sciences, addressing the global energy demand while promoting sustainable and carbon-free energy alternatives.

Patreon Inc. is a membership platform founded in 2013 and based in San Francisco, California, that enables artists and content creators to monetize their work through direct relationships with their fans. The platform allows patrons to support creators on a recurring basis in exchange for exclusive benefits and insights into the creative process. By facilitating connections between creators and their audiences, Patreon empowers a new generation of artists to earn a living from their passions. The platform hosts a wide variety of content, including videos, photographs, artwork, audio clips, and other creative materials, fostering a community where fans can actively participate in and support the work they admire.

Plaid Inc. is a technology platform that facilitates the connection between consumers' bank accounts and various financial applications. Founded in 2012 and headquartered in San Francisco, the company aims to democratize financial services by providing developers with tools and infrastructure to create innovative financial products. Plaid's offerings include a suite of APIs that allow access to detailed transaction histories, real-time account balances, and user identity verification, among other functionalities. These tools enable financial institutions and developers, ranging from startups to large corporations, to build secure and user-friendly applications for personal finance, consumer payments, lending, and more. By streamlining the integration with traditional banking systems, Plaid enhances the ability of consumers and businesses to manage their financial activities efficiently.

Cleo is a family support system that employers offer working parents, by helping families navigate their journey from fertility, to pregnancy, to parenting of newborns, infants, toddlers, and children to age 5. Employers choose Cleo as a strategic partner to power their culture transformation and see increased employee retention, more diverse and inclusive workplaces, and reduced health claims. Cleo supports parents globally in 50+ countries and works with forward-thinking companies like eBay, LinkedIn, Uber, and Straus Family Creamery and many others. Cleo is headquartered in San Francisco and is backed by Felicis Ventures, Forerunner Ventures, Greylock Partners, and NEA. Learn more at hicleo.com.

Theorycraft Games operates as an independent game development studio that operates remotely. The company is in process of developing its first game codenamed Loki. Theorycraft was founded in 2020 and is headquartered in Los Angeles, California, United States.

Satsuma Pharmaceuticals is a clinical-stage biopharmaceutical company focused on developing innovative treatments for migraine. The company's lead product candidate, STS101, is a drug-device combination that features a proprietary dry-powder formulation of dihydroergotamine mesylate. This product is designed for self-administration through a pre-filled, single-use nasal delivery device and is currently undergoing Phase III clinical trials. Founded in 2016 and based in South San Francisco, California, Satsuma aims to provide an effective therapeutic option for individuals suffering from acute migraine episodes.

Burrow, Inc. is a New York-based furniture company that designs, manufactures, and supplies a range of home furnishings, including customizable sofas, sectionals, loveseats, armchairs, and ottomans, as well as tables, rugs, and various accessories. Founded in 2016, Burrow focuses on creating luxury furniture that is both easy to move and comfortable, utilizing sustainably-sourced hardwood and non-toxic, scratch- and stain-resistant fabrics. The company aims to reinvent the home furnishing experience by offering personalized and durable products that allow customers to avoid traditional retail markups. Burrow sells its items through physical showrooms in several states, including Washington, Massachusetts, Texas, and California, as well as through its online platform. The company's manufacturing facility is located in Mexico City, Mexico.

Dandelion Energy, Inc., founded in 2017 and based in Palo Alto, California, specializes in providing affordable geothermal heating and cooling installations. The company has developed a home geothermal system that replaces traditional air conditioning and heating equipment with an efficient heat pump and safe underground pipes. This system harnesses thermal energy from the earth to regulate indoor temperatures and produce hot water, allowing homeowners to transition from conventional heating fuels to a more sustainable geothermal solution. Dandelion Energy aims to make renewable energy accessible and cost-effective for residential customers.

Sagimet Biosciences is a clinical-stage biopharmaceutical company based in San Mateo, California, that specializes in developing novel therapeutics for oncology and infectious diseases. The company focuses on targeting dysfunctional metabolic pathways, particularly through its expertise in fatty acid synthase (FASN) biology. Its lead drug candidate, denifanstat, is a selective FASN inhibitor designed for the treatment of nonalcoholic steatohepatitis (NASH) and is administered as an oral, once-daily pill. Additionally, Sagimet is working on antiviral therapeutics aimed at addressing respiratory syncytial virus, cytomegalovirus, and other human pathogens. Originally known as 3-V Biosciences, Inc., the company rebranded to Sagimet Biosciences in August 2019 and has been active since its incorporation in 2006.

Metromile, Inc. is a digital insurance platform based in San Francisco, California, that specializes in pay-per-mile car insurance. Using a wireless device called Metromile Pulse, which connects to a vehicle's onboard diagnostics port, the company tracks real-time mileage along with location and driving behavior. This data-driven approach allows Metromile to offer personalized auto insurance policies, providing significant savings—averaging 47% compared to traditional insurers. The platform also features automated claims processing and smart driving tools to enhance user experience. In addition to its insurance offerings, Metromile licenses its technology to insurance companies globally, enabling them to improve efficiency and reduce fraud through advanced data analytics.

Databricks Inc. offers a unified data analytics cloud platform that simplifies data engineering and supports collaborative data science. Its core product, Databricks, enables organizations to process and analyze large datasets efficiently, leveraging tools like Apache Spark. The platform is designed for real-time experimentation and robust deployment of production applications, catering to developers and data scientists. Additionally, Databricks provides Databricks Delta, a data management system that combines the scalability of a data warehouse with low-latency streaming capabilities. The company also offers MLflow for managing the machine learning lifecycle and Delta Lake for handling batch and streaming data. Databricks serves a diverse range of industries, including healthcare, finance, manufacturing, and telecommunications. Founded in 2013 and headquartered in San Francisco, with additional offices in London, Amsterdam, and Bengaluru, Databricks has established strategic partnerships to enhance its offerings and foster innovation in data and AI technologies.

Robinhood Financial LLC is an online and mobile application-based discount stock brokerage that caters to self-directed investors. Founded in 2012 and headquartered in Menlo Park, California, the company offers commission-free trading in stocks, options, exchange-traded funds, and cryptocurrencies. It aims to democratize access to financial markets, encouraging users to manage their finances and invest through its user-friendly platform. Robinhood provides various services, including cryptocurrency trading, dividend reinvestment, fractional shares, and recurring investments. The firm generates revenue by routing user orders to market makers for execution, enabling a modern financial services platform supported by proprietary technology. Robinhood operates as a subsidiary of Robinhood Markets, Inc.

SetPoint Medical is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices aimed at treating chronic autoimmune diseases. The company is creating a platform that stimulates the vagus nerve to activate the body's natural inflammatory reflex, leading to a systemic immune-restorative effect. This innovative approach offers an alternative treatment option for conditions such as rheumatoid arthritis and inflammatory bowel disease, with the potential for reduced risks and costs compared to traditional drug therapies. SetPoint Medical, originally known as Innovative Metabolics Inc. until its name change in 2008, aims to provide patients and healthcare providers with effective solutions for managing debilitating inflammatory diseases.

Reneo Pharmaceuticals is a clinical-stage pharmaceutical company based in San Diego, California, that focuses on developing therapies for patients with rare genetic mitochondrial diseases. These conditions are linked to defects in energy metabolism, leading to issues such as muscle weakness and wasting. The company is developing REN001, an oral drug designed to modulate genes involved in mitochondrial function, aiming to enhance adenosine triphosphate (ATP) production, which is essential for cellular energy. By improving mitochondrial activity, Reneo seeks to enhance the daily functioning and quality of life for patients suffering from these disorders. Founded in 2014, Reneo Pharmaceuticals is committed to addressing the needs of individuals with orphan metabolic diseases.

MindTickle is a privately-held company that provides a data-driven sales readiness platform aimed at enhancing the effectiveness of customer-facing teams. With its headquarters in San Francisco and Pune, the platform is utilized by sales teams across various industries to address knowledge and skill gaps through automated training paths, adaptive learning, and virtual coaching tools. MindTickle's solution incorporates gamification and role-play elements, facilitating on-demand training and mobile updates. This comprehensive approach helps organizations assess and certify the readiness of their sales representatives, leading to improved deal sizes, higher win rates, and shorter sales cycles. Investors in MindTickle include Accel, Canaan, NEA, NewView Capital, Norwest Venture Partners, and Softbank.

Relievant Medsystems, Inc. is a medical device company focused on developing minimally invasive treatments for chronic axial low back pain. The company has created the Intracept procedure, which specifically targets the basivertebral nerve to alleviate chronic vertebrogenic low back pain. By delivering targeted energy into the spine, the Intracept System effectively blocks the transmission of pain signals, providing patients with a low-risk therapeutic option. Founded in 2004, Relievant is headquartered in Minneapolis, Minnesota, with additional operations in Sunnyvale, California.

Anyscale, Inc. is a technology company based in Berkeley, California, founded by the creators of the open-source project Ray. It specializes in developing distributed programming platforms and tools that simplify the creation and scaling of artificial intelligence applications. Anyscale's software enables developers and machine learning engineers to effortlessly scale their applications from local environments to the cloud, eliminating the need for complex infrastructure. The company's framework allows users of varying skill levels to build and deploy compute-intensive applications efficiently, facilitating faster and more cost-effective market entry for AI products. Anyscale aims to enhance the end-to-end AI lifecycle, making it accessible for organizations to leverage AI technologies.

Matroid is a computer vision company that provides a studio to create, combine, and use computer vision detectors, without programming. Its platform allows users to create computer vision detectors that recognize the people, events, and objects they are interested in, monitor television streams in real-time, send notifications about custom events on security cameras, and search visual media. Matroid was founded by Reza Zadeh in 2016 and is headquartered in Palo Alto, California.

Willow, founded in 2014 and based in Mountain View, California, is a company that specializes in the development and manufacturing of wearable breast pumps and related breastfeeding products. The company offers a range of items including in-bra breast pumps, milk bags, replacement parts, pumping bras, and accessories like flanges and chargers. Willow's breast pumps are designed to be mobile and hands-free, allowing mothers to pump discreetly and conveniently. The devices are cordless, spill-proof, and equipped with a mobile application that tracks milk output, facilitating a hassle-free pumping experience for mothers on the go.

Everactive, Inc., also known as Everactive Insights, Inc., specializes in the development of wireless sensing devices and technologies tailored for Industrial Internet of Things (IoT) applications. The company produces ultra-low-power chips that enable battery-less wireless sensors, facilitating data generation and analytics for various industrial operations. Its innovations include PsiKick integrated circuits, which support programmable processing, power management, and RF communication. Everactive's solutions encompass steam trap monitoring, flare system monitoring, and machine health monitoring, allowing for continuous analysis of industrial assets. Founded in 2012 and headquartered in Santa Clara, California, Everactive also has locations in Charlottesville, Virginia, and Ann Arbor, Michigan. The company’s technology is based on energy harvesting, enabling low-cost and long-lived instrumentation that supports sustainable and scalable IoT applications.

Patreon Inc. is a membership platform founded in 2013 and based in San Francisco, California, that enables artists and content creators to monetize their work through direct relationships with their fans. The platform allows patrons to support creators on a recurring basis in exchange for exclusive benefits and insights into the creative process. By facilitating connections between creators and their audiences, Patreon empowers a new generation of artists to earn a living from their passions. The platform hosts a wide variety of content, including videos, photographs, artwork, audio clips, and other creative materials, fostering a community where fans can actively participate in and support the work they admire.

Coursera, Inc. operates an online education platform that partners with over 140 universities and organizations globally, providing access to more than 1,000 courses across various fields, including business, computer science, data science, and arts. Established in 2012 and headquartered in Mountain View, California, the platform serves over 20 million registered learners, offering courses that facilitate career advancement and personal development. Coursera's offerings include video lectures, interactive quizzes, and peer-graded assessments, making education accessible to individuals worldwide. The company's business model encompasses three main segments: Consumer, Enterprise, and Degrees, with the majority of its revenue generated from the Consumer segment, which caters to individual learners seeking practical skills and certifications.

Amplyx Pharmaceuticals is a pre-clinical stage company focusing on the development of small molecule drugs with enhanced efficacy and lower toxicity. Amplyx employs a platform approach to improve small molecule drugs by the addition of a second small molecule to an existing drug. The company develops innovative therapies for debilitating and life-threatening diseases that affect people with compromised immune systems. Amplyx Pharmaceuticals was founded in 2006 and is headquartered in San Diego, California.

Robinhood Financial LLC is an online and mobile application-based discount stock brokerage that caters to self-directed investors. Founded in 2012 and headquartered in Menlo Park, California, the company offers commission-free trading in stocks, options, exchange-traded funds, and cryptocurrencies. It aims to democratize access to financial markets, encouraging users to manage their finances and invest through its user-friendly platform. Robinhood provides various services, including cryptocurrency trading, dividend reinvestment, fractional shares, and recurring investments. The firm generates revenue by routing user orders to market makers for execution, enabling a modern financial services platform supported by proprietary technology. Robinhood operates as a subsidiary of Robinhood Markets, Inc.

Mojo Vision Inc. is a company based in Saratoga, California, established in 2015, that specializes in augmented reality technology. The firm is focused on developing high-performance micro-LED displays for various applications, including consumer, enterprise, and government sectors. It has created the world's smallest and densest dynamic display integrated into a smart contact lens, designed to provide users with timely information without disrupting their focus. This innovative product allows for hands-free connectivity and access to relevant information, thereby minimizing reliance on traditional mobile devices. Additionally, Mojo Vision has formed a joint development agreement with Menicon Co., Ltd. to explore smart contact lens products further, leveraging its advanced micro-LED technology and manufacturing processes to disrupt the display industry.

ClearMetal, Inc., based in San Francisco, California, specializes in artificial intelligence software for supply chain operations, focusing on transport and supply chain visibility solutions. Founded in 2014 by experts from Stanford University and leading technology companies, ClearMetal's platform leverages machine learning algorithms to enhance the accuracy and quality of ocean freight data. This cloud-based application consolidates and processes information from multiple sources, providing real-time insights into shipment status and enabling organizations to predict arrival times and manage exceptions effectively. By facilitating access to reliable data, ClearMetal aims to improve logistics efficiency and enhance customer experiences in supply chain management.

Dandelion Energy, Inc., founded in 2017 and based in Palo Alto, California, specializes in providing affordable geothermal heating and cooling installations. The company has developed a home geothermal system that replaces traditional air conditioning and heating equipment with an efficient heat pump and safe underground pipes. This system harnesses thermal energy from the earth to regulate indoor temperatures and produce hot water, allowing homeowners to transition from conventional heating fuels to a more sustainable geothermal solution. Dandelion Energy aims to make renewable energy accessible and cost-effective for residential customers.

NextNav, LLC specializes in developing and deploying advanced positioning technology solutions designed for urban and indoor environments, where traditional GPS signals are insufficient. The company’s positioning system enables mobile devices to accurately determine their location, including height and floor-level information. This technology is integrated into GPS chipsets, mobile phones, and various wireless devices. NextNav offers its services for a range of applications, including emergency response, public safety, and commercial needs that require precise indoor location accuracy. Additionally, the company provides Pinnacle, a plug-in that enhances 3D geolocation experiences by delivering detailed altitude data. Established in 2007 and headquartered in Tyson's Corner, Virginia, NextNav also operates locations in Sunnyvale, California, and Bengaluru, India.

Lily AI is a developer of an e-commerce product discovery platform that enhances the sales capabilities of brands and retailers. The platform integrates customer-centric product attributes into various components of the e-commerce ecosystem, including site search engines, recommendation systems, and SEO/SEM functionalities. By improving on-site search and personalized product discovery, Lily AI supports retailers in the fashion, home, and beauty sectors, leading to significant increases in traffic, conversion rates, revenue, and brand loyalty. Headquartered in Mountain View, California, the company is backed by venture capital.

Geron Corporation is a late-stage clinical biopharmaceutical company headquartered in Menlo Park, California, that specializes in developing therapies for hematologic myeloid malignancies. The company's lead product, imetelstat, is a first-in-class telomerase inhibitor currently undergoing Phase 2/3 clinical trials. This investigational drug aims to inhibit the uncontrolled proliferation of malignant progenitor cells, which can lead to dysfunctional blood cell production, thereby facilitating the recovery of normal blood cell development. Founded in 1990, Geron focuses on advancing treatments for conditions such as myelodysplastic syndromes and myelofibrosis, a rare blood cancer affecting bone marrow. The company also generates revenue through collaboration agreements, milestones, royalties, and licensing arrangements.

Uhana, Inc. is a technology company based in Palo Alto, California, focused on enhancing mobile network operations through its innovative software platform. As a subsidiary of VMware, Uhana develops a real-time network AI engine that leverages advanced research from Stanford University. This platform ingests extensive telemetry data from existing network components and applications, employing machine learning and deep learning techniques to optimize user experiences in demanding applications such as virtual and augmented reality, video streaming, drones, and connected vehicles. Uhana's software provides predictive guidance for both applications and network management, improving performance across various mobile networks. By enabling independent onboarding of applications and mobile networks, Uhana delivers value to over-the-top (OTT) services and network providers alike, enhancing operational efficiency and application quality of experience.

Willow, founded in 2014 and based in Mountain View, California, is a company that specializes in the development and manufacturing of wearable breast pumps and related breastfeeding products. The company offers a range of items including in-bra breast pumps, milk bags, replacement parts, pumping bras, and accessories like flanges and chargers. Willow's breast pumps are designed to be mobile and hands-free, allowing mothers to pump discreetly and conveniently. The devices are cordless, spill-proof, and equipped with a mobile application that tracks milk output, facilitating a hassle-free pumping experience for mothers on the go.

Anyscale, Inc. is a technology company based in Berkeley, California, founded by the creators of the open-source project Ray. It specializes in developing distributed programming platforms and tools that simplify the creation and scaling of artificial intelligence applications. Anyscale's software enables developers and machine learning engineers to effortlessly scale their applications from local environments to the cloud, eliminating the need for complex infrastructure. The company's framework allows users of varying skill levels to build and deploy compute-intensive applications efficiently, facilitating faster and more cost-effective market entry for AI products. Anyscale aims to enhance the end-to-end AI lifecycle, making it accessible for organizations to leverage AI technologies.

ChromaCode, Inc. is a molecular diagnostics company based in Carlsbad, California, founded in 2012. The company specializes in developing innovative testing solutions for infectious diseases, cancer, and non-invasive prenatal testing (NIPT) by utilizing patented mathematical methods and algorithmic enhancements. ChromaCode's products significantly enhance the multiplexing capabilities of quantitative polymerase chain reaction (qPCR) instruments, allowing laboratories to perform cost-effective testing of multiple targets from a single sample. Their offerings include software, reagents, and assays that improve signal processing and overall assay performance, making diagnostics more accessible and efficient. Among their notable products is the HDPCR Tick-Borne Pathogen Panel, a multiplex test that detects various tick-borne pathogens in one assay.

They are co-located in Silicon Valley and New York City, but are open to great talent anywhere. They welcome critical thinkers who are excited to re-write the rules of e-commerce. They promise it will be fun.

Databricks Inc. offers a unified data analytics cloud platform that simplifies data engineering and supports collaborative data science. Its core product, Databricks, enables organizations to process and analyze large datasets efficiently, leveraging tools like Apache Spark. The platform is designed for real-time experimentation and robust deployment of production applications, catering to developers and data scientists. Additionally, Databricks provides Databricks Delta, a data management system that combines the scalability of a data warehouse with low-latency streaming capabilities. The company also offers MLflow for managing the machine learning lifecycle and Delta Lake for handling batch and streaming data. Databricks serves a diverse range of industries, including healthcare, finance, manufacturing, and telecommunications. Founded in 2013 and headquartered in San Francisco, with additional offices in London, Amsterdam, and Bengaluru, Databricks has established strategic partnerships to enhance its offerings and foster innovation in data and AI technologies.

Instabase, Inc. is a technology company that develops a platform aimed at automating document processing workflows and analyzing unstructured data. Founded in 2015 and based in San Francisco, California, the company provides a range of services, including optical character recognition, data classification and extraction, and natural language processing. Its platform is designed to help organizations in various sectors, such as insurance, finance, and healthcare, streamline operations and improve decision-making. By enabling businesses to embed artificial intelligence into their systems and processes, Instabase facilitates the development of applications that address significant operational challenges, particularly in the realm of intelligent document processing.

SetPoint Medical is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices aimed at treating chronic autoimmune diseases. The company is creating a platform that stimulates the vagus nerve to activate the body's natural inflammatory reflex, leading to a systemic immune-restorative effect. This innovative approach offers an alternative treatment option for conditions such as rheumatoid arthritis and inflammatory bowel disease, with the potential for reduced risks and costs compared to traditional drug therapies. SetPoint Medical, originally known as Innovative Metabolics Inc. until its name change in 2008, aims to provide patients and healthcare providers with effective solutions for managing debilitating inflammatory diseases.

HackerOne, based in San Francisco and founded in 2012, operates a hacker-powered security platform that connects businesses with cybersecurity researchers and penetration testers. The platform facilitates bug bounty solutions, allowing organizations to proactively identify and address security vulnerabilities through collaboration with a global community of ethical hackers. By offering tools for vulnerability disclosure and response programs, HackerOne helps organizations streamline their vulnerability coordination processes while enhancing their ability to protect consumer data and maintain trust. The company serves as a mediator between hackers and businesses, enabling the identification of security issues before they can be exploited by malicious actors.

Yubico AB is a company specializing in authentication solutions aimed at enhancing digital security for enterprises and online services. Founded in 2007 and headquartered in Stockholm, Sweden, with an additional location in Sunnyvale, California, Yubico is renowned for its YubiKey, a hardware authentication token that provides strong two-factor authentication through a simple USB interface. The YubiKey is compatible with numerous platforms and services, offering various authentication methods such as one-time passcodes and passwordless login, which help prevent unauthorized access and identity theft. Yubico also offers YubiEnterprise Delivery, a cloud-based service for efficient YubiKey distribution, and YubiKey Firmware for secure pre-boot settings. The company's clientele includes individual developers, universities, and government entities, reflecting its broad impact across diverse industries including healthcare, finance, and technology. Yubico continues to innovate, expanding its product offerings to address the evolving challenges of digital security.

Sagimet Biosciences is a clinical-stage biopharmaceutical company based in San Mateo, California, that specializes in developing novel therapeutics for oncology and infectious diseases. The company focuses on targeting dysfunctional metabolic pathways, particularly through its expertise in fatty acid synthase (FASN) biology. Its lead drug candidate, denifanstat, is a selective FASN inhibitor designed for the treatment of nonalcoholic steatohepatitis (NASH) and is administered as an oral, once-daily pill. Additionally, Sagimet is working on antiviral therapeutics aimed at addressing respiratory syncytial virus, cytomegalovirus, and other human pathogens. Originally known as 3-V Biosciences, Inc., the company rebranded to Sagimet Biosciences in August 2019 and has been active since its incorporation in 2006.

Holloway, Inc. is a digital publishing company that specializes in creating and publishing comprehensive online guides on various work-related topics. Founded in 2016 and based in San Francisco, California, the company offers a library of book-length guides that are written and regularly updated by teams of industry experts. Holloway aims to distill extensive research and knowledge into practical resources, assisting readers in making informed decisions. Originally known as Feynman Labs, Inc., the company rebranded to Holloway, Inc. in April 2018, reflecting its focus on providing reliable, in-depth information in the non-fiction genre.

Burrow, Inc. is a New York-based furniture company that designs, manufactures, and supplies a range of home furnishings, including customizable sofas, sectionals, loveseats, armchairs, and ottomans, as well as tables, rugs, and various accessories. Founded in 2016, Burrow focuses on creating luxury furniture that is both easy to move and comfortable, utilizing sustainably-sourced hardwood and non-toxic, scratch- and stain-resistant fabrics. The company aims to reinvent the home furnishing experience by offering personalized and durable products that allow customers to avoid traditional retail markups. Burrow sells its items through physical showrooms in several states, including Washington, Massachusetts, Texas, and California, as well as through its online platform. The company's manufacturing facility is located in Mexico City, Mexico.

Heap automates away the annoying parts of analytics so that companies can focus on making smarter business decisions. The company's mission is to power business decisions with truth. It encourages companies to focus on discovering insights and taking action. With Heap, organizations can remove technical jams and obtain a single comprehensive view of the customers. The software automatically gathers, organizes, analyzes, and connects customer data, so businesses can create more valuable products and experiences. Heap serves over 6,000 companies in ecommerce, SaaS, fintech, retail, media, and beyond including Twilio, LendingClub, App Annie, Optimizely, Morningstar, Monotype, and Casper. Heap was founded on 2013 and is headquartered in San Francisco, California.

Robinhood Financial LLC is an online and mobile application-based discount stock brokerage that caters to self-directed investors. Founded in 2012 and headquartered in Menlo Park, California, the company offers commission-free trading in stocks, options, exchange-traded funds, and cryptocurrencies. It aims to democratize access to financial markets, encouraging users to manage their finances and invest through its user-friendly platform. Robinhood provides various services, including cryptocurrency trading, dividend reinvestment, fractional shares, and recurring investments. The firm generates revenue by routing user orders to market makers for execution, enabling a modern financial services platform supported by proprietary technology. Robinhood operates as a subsidiary of Robinhood Markets, Inc.

Collective Health is a prominent health benefits platform that streamlines the management of medical, dental, vision, and pharmacy services for employees and their families. By offering an integrated solution through a cloud-based self-insurance platform, the company simplifies the administration of health plans via a single portal. This platform provides users with clear guidance, live concierge support, and digital tools to facilitate the navigation and management of healthcare services. Collective Health aims to reduce the complexities of delivering health benefits, enhance the member experience, and promote healthier outcomes for both employees and organizations. Headquartered in San Francisco, California, the company also has offices in Chicago, Illinois, and Lehi, Utah.

Aquabyte, Inc. specializes in developing advanced monitoring systems for the fish farming industry, employing computer vision and machine learning technologies. Founded in 2017 and headquartered in San Francisco, California, with an office in Bergen, Norway, Aquabyte's smart camera system enables real-time applications such as detecting biomass, counting sea lice, and monitoring fish appetite. The accompanying web dashboard provides continuous metrics to enhance operational efficiency. By integrating these technologies, Aquabyte aims to reduce operational costs and fish mortality while promoting sustainability in aquaculture. The company’s innovative approach seeks to address the challenges faced by fish farms, ultimately contributing to a more efficient and environmentally friendly industry.

Genies, Inc. is a company that specializes in avatar technology to enhance social media and messaging applications. Founded in 2011 and based in Venice, California, Genies enables users to create personalized digital avatars, which can be utilized for self-expression and interaction in various digital environments. The company has gained traction with cultural influencers and has established partnerships with major music labels, serving as the official avatar provider for artists. Genies recently expanded its offerings with an Augmented Reality (AR) Developer Kit, allowing developers to create interoperable avatar experiences. Their platform includes features for designing digital fashion and engaging in avatar-based interactive experiences. By leveraging its unique technology, Genies facilitates brand engagement and the sale of digital goods, appealing particularly to the college demographic and millennial audience. The company has raised significant investment, achieving a valuation of $1 billion.

Reneo Pharmaceuticals is a clinical-stage pharmaceutical company based in San Diego, California, that focuses on developing therapies for patients with rare genetic mitochondrial diseases. These conditions are linked to defects in energy metabolism, leading to issues such as muscle weakness and wasting. The company is developing REN001, an oral drug designed to modulate genes involved in mitochondrial function, aiming to enhance adenosine triphosphate (ATP) production, which is essential for cellular energy. By improving mitochondrial activity, Reneo seeks to enhance the daily functioning and quality of life for patients suffering from these disorders. Founded in 2014, Reneo Pharmaceuticals is committed to addressing the needs of individuals with orphan metabolic diseases.

Coursera, Inc. operates an online education platform that partners with over 140 universities and organizations globally, providing access to more than 1,000 courses across various fields, including business, computer science, data science, and arts. Established in 2012 and headquartered in Mountain View, California, the platform serves over 20 million registered learners, offering courses that facilitate career advancement and personal development. Coursera's offerings include video lectures, interactive quizzes, and peer-graded assessments, making education accessible to individuals worldwide. The company's business model encompasses three main segments: Consumer, Enterprise, and Degrees, with the majority of its revenue generated from the Consumer segment, which caters to individual learners seeking practical skills and certifications.

Metabase is an open-source analytics and business intelligence application founded in 2014 and based in San Francisco, California. The platform enables users to create dashboards and reports, facilitating the measurement, analysis, and sharing of data to address complex business challenges. Metabase offers various professional services, including managed hosting and support, as well as assistance with implementing customized analytics solutions. This enables organizations to track data trends over time, enhancing their decision-making processes.