National Science Foundation

Novaurum Biosciences specializes in the development of AuPEC, a cell-based encapsulation technology aimed at enhancing the performance of implanted medical devices. This innovative platform integrates microbiology and nanotechnology to create nano-biological coatings for orthopedic implants. By reducing infection rates and promoting tissue regeneration, Novaurum's technology enables medical professionals to improve patient outcomes significantly. The company's approach offers a novel solution for addressing common challenges associated with implantable devices, ultimately contributing to safer and more effective medical interventions.

Dynocardia, a biomedical device development company, committed to satisfying critical unmet needs to improve healthcare. It offers direct, beat-to-beat measurement of blood pressure that is wrist-wearable, mobile, and easy to use, with the accuracy of intra-arterial lines. The company was founded in 2018 and headquartered in Lowell, Massachusetts.

Amplified Sciences LLC is a molecular diagnostics company focused on the early detection of debilitating diseases, particularly pancreatic cancer and kidney disease. Utilizing an ultra-sensitive molecular sensing technology licensed from Purdue University, the company’s platform can detect disease markers at the single molecule level, enabling accurate diagnosis from bodily fluids such as urine and saliva. This versatile technology is designed for scalability to point-of-care applications, allowing for effective disease screening with a favorable cost structure. Amplified Sciences has developed a working prototype and has published proof of concept data, positioning itself to meet significant unmet medical needs in diagnostics. Founded in 2016 and based in West Lafayette, Indiana, the company was previously known as Nutrabiotix.

CenSyn is a brain health screening platform focused on enhancing the accessibility and efficiency of diagnosing various neurological conditions. The company has developed a handheld EEG monitoring device aimed at accelerating the screening process for Alzheimer's, traumatic brain injury, and epilepsy. Their proprietary software facilitates long-term management of brain health by allowing clinicians to wirelessly monitor and record brain electrical activity in real time. This innovative approach enables the rapid detection of altered mental status, supporting timely diagnosis and immediate treatment, ultimately reducing inpatient costs and improving care for diverse patient populations.

Mente develops a surgical instruments tracking system aimed at enhancing the surgical experience while minimizing costs for hospitals, surgical teams, and patients. The company's innovative approach employs predictive analytics to monitor surgical instruments in the operating room, generating reliable, real-time data streams. This technology significantly improves resource management, ensuring that healthcare teams have the necessary tools readily available during surgeries. By focusing on efficiency and effectiveness, Mente seeks to transform the operational dynamics of surgical procedures.

Samay is a developer of an AI-enabled wearable device focused on remote respiratory health management, specifically targeting chronic obstructive pulmonary disease (COPD). The company's innovative chest patches utilize patented technology to diagnose COPD with 90% accuracy and identify exacerbation biomarkers at 83% accuracy, all while allowing patients to remain at home. The device continuously monitors various respiratory metrics, including pulmonary volumes, trapped air, respiratory and heart rates, breathing sounds, and temperature for up to two weeks. This real-time data collection empowers users to analyze their respiratory health and receive actionable insights to enhance their day-to-day well-being. Additionally, Samay is creating an AI-assisted management and diagnostic platform that supports both patients and doctors throughout the care continuum, from detecting exacerbations to determining effective therapies for more personalized treatment.

Quantivly, Inc. is a technology company based in Somerville, Massachusetts, that specializes in artificial intelligence solutions for radiology. Founded in 2019, it focuses on developing software that manages and analyzes MRI imaging workflows. The company's platform enables radiology providers to access a vendor-neutral, granular source of operational data by analyzing and harmonizing scanner information. This capability supports radiology departments and imaging centers in making data-driven decisions, improving operational efficiency, and enhancing patient-centered healthcare. By offering tools for data liquidity and analysis, Quantivly aims to increase access to medical imaging and drive advancements in research and patient care within the radiology sector.

Eysz is developing a digital health platform that measures disease progression, intervention efficacy and side effects to assist clinicians in developing a personalized care plan for neurological diseases. Doctors currently rely on patient self-reported data and subjective clinical exams to manage and treat chronic neurological disorders. The lack of a reliable biomarker in neurological disease leads to economic burdens of $1.7T in the US and Europe alone and stagnant patient outcomes with no significant improvement in outcomes in the last 30 years. Eysz is using analysis of eye-movements as a biomarker to assess brain health across neurological disorders starting with epilepsy – a disorder characterized by recurrent seizures. After completing a successful clinical study sponsored by the NIH and NSF Eysz will be releasing their first product to diagnose and monitor childhood absence epilepsy in Q3 2023.

NeuroGeneces utilizes advanced neuroscience, sleep expertise, and artificial intelligence to deliver brain health assessments aimed at enhancing cognitive longevity. The company has received funding from various reputable sources, including government agencies and private investors. Its flagship product is a sleep headband equipped with machine learning algorithms that analyze EEG data, comparing it against a proprietary normative database to determine an individual's biological brain age. This innovative approach allows healthcare practitioners to objectively evaluate brain function and develop targeted intervention strategies. Additionally, the device monitors sleep patterns, including quantity, quality, and heart rate variability, providing essential support for clinicians focused on wellness and preventative care. By identifying neurodegeneration early, NeuroGeneces aims to empower users to optimize their mental and physical performance.

Malcova is an early-stage medical device startup focused on developing advanced imaging solutions for the detection and diagnosis of breast cancer, particularly in women with dense breast tissue. The company employs its proprietary Narrow-Beam Computed Tomography technology, which enhances the effectiveness of medical imaging compared to traditional methods like mammography and tomosynthesis. Additionally, Malcova integrates artificial intelligence in its software to improve the functionality of its devices. The aim is to provide clinicians with tools that facilitate accurate diagnosis while ensuring that the imaging process is safe, comfortable, and accessible for patients. Through these innovations, Malcova seeks to enhance the overall experience and outcomes for breast cancer detection and treatment.

ProMedix is a medical device startup founded in 2019 and headquartered in Portland, Oregon. The company specializes in developing noninvasive, fingertip patient monitors aimed at enhancing the recognition of circulatory dysfunction. Its innovative devices facilitate diagnostic evaluations and the monitoring of therapeutic interventions for various medical conditions, such as trauma, dehydration, and sepsis. By improving home patient monitoring, ProMedix enables physicians to streamline care in both home and critical settings, thereby preventing unnecessary acute visits and enhancing emergency or critical care outcomes.

ReSuture is a company that specializes in creating high-fidelity physical simulations for surgical training, particularly focusing on open vascular procedures. Established in 2019, its primary goal is to enhance patient outcomes and minimize surgical complications by providing a superior training experience for aspiring surgeons. The company develops advanced surgical instruments that address challenges in medical simulation, allowing users to practice vascular surgical skills in a controlled environment. These instruments replicate the mechanical properties of human vascular tissue, enabling realistic simulations that improve psychomotor skills and reduce training time for medical practitioners.

PneumoNIX Medical is focused on creating gel-based technologies aimed at preventing complications related to percutaneous procedures, particularly in the context of soft tissue biopsies. The company's innovative medical devices are designed to minimize the risk of collapsed lung complications that may occur during CT-guided lung biopsies. By addressing these critical issues, PneumoNIX Medical seeks to enhance patient safety and improve outcomes in medical interventions that involve needle insertions.

Vivifi Medical develops a laparoscopic device that allows for the quick connection of two blood vessels. The company is headquartered in Houston, Texas.

Moshion is a data-driven platform for nurse workflow optimization to address the nursing shortage. We act as another set of eyes to help nurses using our 3D image sensors (100% privacy-preserving) to collect movement data analyzed by our machine learning models. Moshion aims to enter the remote patient monitoring market by focusing on patient turning to prevent pressure injuries. Pressure injuries are wounds that can develop when a patient (often bed bound) stays in the same position. These can be prevented by adhering to turning protocols. Our software tracks that adherence, provides personalized turn schedules for each patient, sends nurses gentle reminders, and auto-documents.

Sharper Sense is a company focused on wearable neurotechnology designed to enhance sensory acuity, including vision, hearing, and touch. The firm has developed a neuromodulation patch that employs comfortable, noninvasive electrical stimulation to improve sensory processing. This technology has both clinical and commercial applications, particularly in treating sensory processing disorders and sensory loss. By enhancing performance and safety, Sharper Sense aims to provide users with a clearer and more accurate perception of their surroundings.

Senseer Health, founded in 2017, focuses on addressing the chronic disease market by developing Smart Medical Device Therapies for managing various chronic conditions, which affect a significant portion of older adults. The company's innovations began with patented microsensors that monitor implantable devices for patients with hydrocephalus, renal, and cardiovascular diseases. To enhance the effectiveness of these microsensor-enabled devices, Senseer has incorporated advanced wearable and ambient sensor technologies. The integration of these multi-modal sensor technologies with an IoT software platform allows for the utilization of proprietary data sets and predictive analytics. This comprehensive approach provides healthcare providers with tools for remote monitoring and timely interventions, ultimately aiming to improve the quality of life for individuals with chronic conditions while reducing costs and enhancing patient safety.

Claria Medical is a pre-commercial medical device start-up focused on developing innovative solutions for women's healthcare, specifically targeting unmet needs in gynecologic surgery. The company specializes in creating minimally invasive surgical tools designed to enhance procedures such as hysterectomy and myomectomy. Claria Medical has received recognition for its early achievements, including a “Safer Technologies Designation” from the U.S. Food and Drug Administration. Additionally, the company has secured funding through private investments as well as grants from the National Science Foundation and the National Institutes of Health to support its product development efforts. By providing specialized surgical assistance, Claria Medical aims to improve outcomes for women undergoing these procedures.

Evolution Devices, Inc. is a neuro rehabilitation technology company based in Berkeley, California, focused on enhancing mobility for individuals with neurological impairments. The company’s flagship product, EvoWalk, is a bio-electronic wearable device that utilizes functional electrical stimulation and artificial intelligence to track walking patterns and personalize rehabilitation therapy. EvoWalk is designed for patients recovering from conditions such as stroke, multiple sclerosis, ALS, cerebral palsy, traumatic brain injury, and incomplete spinal cord injury. The device employs sensors that deliver electrical stimulation to leg muscles and the peroneal nerve, aiding in foot elevation during walking. This technology aims to eliminate foot drop, reduce fatigue, and minimize the risk of tripping accidents. Evolution Devices, formerly known as Foot++, Inc., was established in 2017 and rebranded in September 2019.

CoLabs Inc. is a medical device manufacturing company based in Morgan Hill, California, established in 2012. The company specializes in developing Ventor, an emergency airway and ventilation system designed to enhance airway management and ventilation during cardiac arrest situations. This innovative device aims to provide medical professionals with a new approach to effectively manage patients experiencing cardiac arrest, facilitating better diagnosis and treatment during critical emergencies.

NeuroGeneces utilizes advanced neuroscience, sleep expertise, and artificial intelligence to deliver brain health assessments aimed at enhancing cognitive longevity. The company has received funding from various reputable sources, including government agencies and private investors. Its flagship product is a sleep headband equipped with machine learning algorithms that analyze EEG data, comparing it against a proprietary normative database to determine an individual's biological brain age. This innovative approach allows healthcare practitioners to objectively evaluate brain function and develop targeted intervention strategies. Additionally, the device monitors sleep patterns, including quantity, quality, and heart rate variability, providing essential support for clinicians focused on wellness and preventative care. By identifying neurodegeneration early, NeuroGeneces aims to empower users to optimize their mental and physical performance.

Samay is a developer of an AI-enabled wearable device focused on remote respiratory health management, specifically targeting chronic obstructive pulmonary disease (COPD). The company's innovative chest patches utilize patented technology to diagnose COPD with 90% accuracy and identify exacerbation biomarkers at 83% accuracy, all while allowing patients to remain at home. The device continuously monitors various respiratory metrics, including pulmonary volumes, trapped air, respiratory and heart rates, breathing sounds, and temperature for up to two weeks. This real-time data collection empowers users to analyze their respiratory health and receive actionable insights to enhance their day-to-day well-being. Additionally, Samay is creating an AI-assisted management and diagnostic platform that supports both patients and doctors throughout the care continuum, from detecting exacerbations to determining effective therapies for more personalized treatment.

Qualia Oto is a biomedical device company focused on advanced cochlear implant technology. It utilizes its core innovations to produce top-quality, shape-changing polymers and matrix-addressed electrode arrays embedded in devices for individuals' medical and personal needs. The company's technology enables higher channel count cochlear implants and auditory brainstem implants for more precise auditory nerve stimulation and the eventual incorporation of more complex, machine learning-based stimulation. Qualia Oto was founded in 2017 in Dallas, TX.

Rush River Research offers mechanical and electrical design, epidemiology, and medical device project management to take ideas from concept to product. They use state-of-the-art electronics and materials. They partner with medical device companies, physicians, and academics who are also committed to improving healthcare devices.

Medical Device company developing the most affordable, high-end, ultraportable ventilator on the market.

Ai-Ris offers automated retinal examinations for primary care. Their retinal imaging system allows general practitioners to screen for diabetic retinopathy without the presence of a specialist. This system consists of a portable headset that uses machine learning algorithms to classify images of the retina of patients without dilating their pupils.

Hypersound Medical provides neuromodulatory methods using neurostimulation principles. They concern peripheral nerve stimulation, spinal cord stimulation, deep brain stimulation, motor cortex stimulation, and repetitive transcranial magnetic stimulation.

NeuRx Medical specializes in developing percutaneous thrombectomy technologies aimed at treating ischemic stroke and other vascular conditions. The company designs devices that facilitate rapid clot stabilization, retention, and retrieval during image-guided thrombectomy procedures. By addressing unmet needs in current medical systems, NeuRx Medical's innovations enable endovascular specialists to enhance patient outcomes and increase survival rates following large vessel occlusion (LVO) strokes and conditions such as deep vein thrombosis.

Our mission is to promote innovation that empowers people to have the knowledge and tools to solve everyday medical problems in any setting. We do this by providing a doctor’s approach to stopping nosebleeds at your fingertips. Bleed Freeze allows people to confidently take control and treat nosebleeds anywhere.

Renerva is a growing medical device company that specializes in the development and commercialization of implantable technologies designed to enhance peripheral nerve repair procedures. The company's products aim to facilitate nerve repair, recovery, and storage, focusing on improving patient outcomes and accelerating healing processes. By providing innovative surgical devices, Renerva enables healthcare professionals to effectively assist patients in regaining function following nerve injuries.

Dynocardia, a biomedical device development company, committed to satisfying critical unmet needs to improve healthcare. It offers direct, beat-to-beat measurement of blood pressure that is wrist-wearable, mobile, and easy to use, with the accuracy of intra-arterial lines. The company was founded in 2018 and headquartered in Lowell, Massachusetts.

Aurie is a medical device company based in New York, established in 2018. It focuses on developing a reusable urinary catheterization system aimed at improving the quality of life for individuals with disabilities. By providing a convenient, discreet, and hygienic catheterization option, Aurie seeks to reduce the risk of infections and enhance users' confidence and control over their healthcare needs. The company's innovative approach empowers users to manage their condition more effectively, enabling them to lead active and fulfilling lives.

Isolere Bio is a biotechnology company dedicated to simplifying the purification of biotherapeutics, particularly monoclonal antibodies and Adeno-Associated Viruses (AAV). Co-founded with the aim of enhancing global access to essential drugs, Isolere Bio develops innovative manufacturing technologies that utilize a straightforward Tangential Flow Filtration (TFF) setup. This approach facilitates a seamless transition from laboratory-scale processes to large-scale industrial production, thereby improving efficiency within the bioprocessing industry. As monoclonal antibodies continue to gain prominence as effective therapeutics and important research tools, Isolere Bio's work plays a crucial role in advancing the development of new diagnostics and treatments.

Pathotrak, LLC, founded in 2016 and based in College Park, Maryland, develops innovative food safety testing kits that significantly enhance the detection of food-borne pathogens, such as Salmonella and E. coli. Utilizing advanced microfiltration technology, Pathotrak's kits reduce the testing time from 1-2 days to just 6 hours, streamlining the traditional 22-hour enrichment process. This rapid detection capability not only ensures compliance with FDA and USDA regulations but also integrates seamlessly into existing detection systems. By minimizing holding times and associated costs, as well as enabling quicker product releases, Pathotrak's technology aims to transform food safety practices and logistics in the industry, ultimately helping to prevent dangerous outbreaks and improve overall food safety.

CereVu Medical develops AI-driven proprietary algorithms and data analytics designed to improve patient care. Their device consists of a small, wearable, single-use patch that adheres to a patient's forehead to communicate with a reusable monitoring console and incorporates the use of proprietary signal processing and algorithms that utilize personalized cerebral hemodynamic information, enabling physicians to determine a continuous pain score and track the effectiveness of prescriptions to deliver treatment as per the needs of the patient.

OsciFlex LLC, founded in 2017 and based in Philadelphia, Pennsylvania, specializes in developing a wearable medical device aimed at preventing blood clots in patients. The device functions by stimulating calf muscle contractions through a muscle stretch reflex, which promotes valve sinus recirculatory flow. This innovative approach helps to prevent venous thromboembolism (VTE), a serious condition that can lead to significant health complications. By offering an alternative to traditional anti-coagulation pharmaceuticals, which can be costly and carry risks, OsciFlex aims to enhance patient care and reduce healthcare costs associated with blood clot management.

Bired Imaging specializes in infrared imaging technology aimed at enhancing breast cancer detection and localization, particularly in patients with dense breast tissue. Their medical imaging platform employs thermography and a proprietary computerized detection algorithm, which allows for the accurate identification of tumor size and location. This innovative approach enables healthcare professionals to detect high-risk patients at earlier stages, improving screening efficacy while also being cost-effective. Bired Imaging's solutions serve as an important adjunctive technology in breast cancer screening, contributing to more precise diagnostic processes.

IntuiTap Medical is focused on improving the accuracy and efficiency of spinal puncture procedures, which often suffer from challenges related to precision and patient discomfort. The company has developed a handheld device that is the first comprehensive solution for spinal-needle placements. This innovative device integrates imaging of the spine with needle guidance and analytics, allowing healthcare professionals to perform lumbar punctures, spinal anesthesia, and epidurals with greater confidence. By streamlining these procedures, IntuiTap Medical aims to enhance the overall experience for both clinicians and patients while reducing procedural costs.

Huxley Medical is a private company focused on the development of medical devices. The company operates a flexible medical platform that aims to ensure continuity of care for patients, regardless of their location or healthcare system. By collaborating with leading clinicians and basic science researchers, Huxley Medical creates and markets innovative devices and algorithms. This approach enhances user access to a wide range of disease diagnoses and treatment options, ultimately improving patient care and outcomes.

Quadralynx provides wearable biometric devices for adults with motor speech disorders, especially those with volume control issues due to Parkinson’s disease and related neurological disorders. Their device alerts the user via a vibration of a pathological voice state.

Eysz is developing a digital health platform that measures disease progression, intervention efficacy and side effects to assist clinicians in developing a personalized care plan for neurological diseases. Doctors currently rely on patient self-reported data and subjective clinical exams to manage and treat chronic neurological disorders. The lack of a reliable biomarker in neurological disease leads to economic burdens of $1.7T in the US and Europe alone and stagnant patient outcomes with no significant improvement in outcomes in the last 30 years. Eysz is using analysis of eye-movements as a biomarker to assess brain health across neurological disorders starting with epilepsy – a disorder characterized by recurrent seizures. After completing a successful clinical study sponsored by the NIH and NSF Eysz will be releasing their first product to diagnose and monitor childhood absence epilepsy in Q3 2023.

CorInnova Incorporated provides device-based therapies for the treatment of congestive heart failure. CorInnova’s non-blood-contacting soft robotic cardiac assist device could potentially triple or quadruple the number of heart failure patients who could be eligible for such a life-saving device therapy.”

Averto Medical is a manufacturer of medical devices focused on addressing gastrointestinal diseases. The company specializes in developing innovative solutions designed to facilitate minimally invasive colorectal tumor removal, which aims to reduce the need for multiple surgical procedures and associated complications. By providing effective medical care options for patients suffering from gastrointestinal disorders, Averto Medical seeks to improve patient outcomes and streamline treatment processes in this critical area of healthcare.

BioSapien is a pre-clinical biotechnology company focused on creating innovative biodegradable implantable products for oncology applications. The company is developing a 3D-printed drug delivery platform that utilizes a biodegradable mesh to deliver active pharmaceutical ingredients (APIs) directly to tumor sites, thereby minimizing systemic side effects associated with traditional therapies. Their flagship product, the MediChip, is designed to administer FDA-approved high-dose systemic therapies in a localized and sustained manner, enhancing the quality of patient care. Current research is focused on applications for pancreatic and lung cancers, with plans to expand the pipeline to include other types such as colorectal, breast, and stomach cancers. By targeting drug delivery directly to cancerous tissues, BioSapien aims to improve treatment efficacy while reducing toxicity for patients.

ColoWrap, LLC develops ColoWrap, a non-invasive medical device that prevents looping within the colon during colonoscopies by exerting pressure on the patient’s lower abdomen. The company was incorporated in 2012 and is based in Durham, North Carolina.

Clairways provides smart lung monitoring for pharmaceutical clinical trials. Clairways' wearable lung function monitor captures all of the most important respiratory metrics for people suffering from asthma, COPD, CF, or other chronic respiratory diseases.

Precision Neuroscopics is a medical device company located in Pittsburgh, Pennsylvania, specializing in the development of advanced high-density electroencephalography (EEG) systems. These innovative systems are designed to non-invasively detect brain signals that indicate worsening traumatic brain injuries. The company's focus is on creating engineering technologies that enhance the density, durability, and usability of brain recording systems. By improving the quality of EEG signal recordings, Precision Neuroscopics aims to assist clinicians in reducing clinical time and costs associated with brain monitoring, ultimately enhancing patient care.

Envivo Bio develops a non-invasive device that collects microbiome samples from all regions of the human gastrointestinal tract. The company is based in San Carlos, California.

Green Sun Medical, LLC is a medical device company based in Fort Collins, Colorado, specializing in the design, development, and manufacturing of orthotic braces for treating Adolescent Idiopathic Scoliosis (AIS) and Kyphosis. Founded in 2013, the company focuses on creating a dynamic spinal alignment brace that applies continuous corrective pressure to the spine, assisting in the management of spinal deformities. This innovative brace not only promotes effective treatment but also enables physicians to monitor its performance remotely in real-time, thereby enhancing patient care and recovery outcomes. Green Sun Medical is dedicated to advancing spinal health through its technology-driven solutions.

CollaMedix specializes in the development of collagen-based medical devices aimed at addressing soft tissue repair and augmentation. The company focuses on treating stress urinary incontinence in women, a condition that results in urine leakage during activities such as laughing, coughing, sneezing, lifting, and exercising. CollaMedix utilizes proprietary collagen materials to create a bio-inductive scaffold, which is a strong fabric designed to support human tissue and facilitate rapid cell integration. This innovative approach allows researchers to explore new and effective treatments for female pelvic health, ensuring safety and efficacy in their medical solutions.

xMD Diagnostics, based in Annapolis, Maryland, specializes in biotechnology within the healthcare sector. The company develops molecular diagnostics tools that use high-throughput microdissection technology to improve cancer diagnosis and management. These tools are designed to isolate, procure, and enrich cells of interest from biopsy and other specimen samples. This process facilitates various downstream analyses, including PCR, genomic or proteomic testing, and next-generation sequencing. By enhancing the capabilities of clinical and research laboratories, xMD Diagnostics supports pathologists, oncologists, and other healthcare professionals in diagnosing, monitoring, and treating patients with cancer and serious genetic diseases.

Synopic is building the next generation of depth-enabled cameras to improve visualization and decision making during medical procedures. By utilizing a single camera implementation, Synopic is solving the challenge of capturing measurable 3D information for applications like endoscopy and other minimally invasive procedures where space in instruments is at a premium.

Niche Biomedical is a platform and therapy development firm that specializes in creating innovative solutions for chronic injuries and disorders that have not responded to traditional pharmacological treatments. The company has developed ANEUVO®, which focuses on addressing these challenging medical conditions. Among its notable innovations is ExaStim®, a non-invasive neuromodulation system that has received FDA Breakthrough Device Designation for the treatment of spinal cord injuries. Additionally, Niche Biomedical is advancing a gastrointestinal therapeutic device aimed at alleviating postoperative ileus and restoring gastrointestinal motility. This device leverages bioelectronic medicine to revolutionize treatment options for various diseases and injuries that are difficult to manage with conventional pharmaceuticals. The company is also capable of developing miniaturized implantable devices that maintain sophisticated functionality, allowing for targeted neuromodulation therapies.

Empo Health specializes in in-home health monitoring solutions that enhance patient care by integrating seamlessly into daily life. The company has developed an innovative imaging bathroom scale and a digital health platform aimed at detecting early signs of diabetic foot conditions, thereby helping to prevent amputations. By providing reliable visual data outside of clinical settings, Empo Health enables both patients and clinicians to monitor health effectively and maintain standards of care. Through its advanced technology, the company seeks to improve health outcomes and foster proactive management of chronic conditions.

Infusense is a developer of medical devices focused on delivering immediate and accurate measurements for clinical and industrial applications. The company utilizes electrochemistry to quantify lipophilic drugs, addressing unmet needs in drug safety and monitoring. Infusense's platform enables physicians to obtain real-time clinical data, allowing for faster and more personalized care by measuring drug levels directly from a drop of blood or saliva, without the need for sample processing.

ZelosDx specializes in the development of blood testing products aimed at advancing research in brain health and diseases. The company provides researchers with access to proprietary technology that can be licensed and adapted for blood testing kits and automated laboratory equipment. Additionally, it offers pharmaceutical collaborators biomarker technology to support drug discovery efforts. By delivering critical data for diagnosis, monitoring, and evaluating therapeutic responses, ZelosDx facilitates significant advancements in the understanding and treatment of brain-related conditions.

Millions of people suffer from Sickle Cell Disease and other hemolytic anemias. KovaDx is making healthcare accessible to these individuals by providing an affordable and easy to use point-of-care solution. Our system is based on Quantitative Phase Imaging and uses deep learning to make predictions.

Samay is a developer of an AI-enabled wearable device focused on remote respiratory health management, specifically targeting chronic obstructive pulmonary disease (COPD). The company's innovative chest patches utilize patented technology to diagnose COPD with 90% accuracy and identify exacerbation biomarkers at 83% accuracy, all while allowing patients to remain at home. The device continuously monitors various respiratory metrics, including pulmonary volumes, trapped air, respiratory and heart rates, breathing sounds, and temperature for up to two weeks. This real-time data collection empowers users to analyze their respiratory health and receive actionable insights to enhance their day-to-day well-being. Additionally, Samay is creating an AI-assisted management and diagnostic platform that supports both patients and doctors throughout the care continuum, from detecting exacerbations to determining effective therapies for more personalized treatment.

Theromics Inc. is a biotechnology company focused on developing innovative cell therapies, particularly in the field of thermal ablation for cancer treatment. Founded in 2016 and based in West Bridgewater, Massachusetts, the company has created HeatSYNC Gel, a biopolymer thermal accelerant designed to enhance the effectiveness of microwave and radiofrequency ablation procedures. This gel improves the delivery and absorption of thermal energy in soft tissue and bone, optimizing the ablation zone's shape and volume. By increasing local tissue electrical conductivity, HeatSYNC Gel helps to prevent heat loss due to blood flow, allowing for more precise targeting of tumors and protecting surrounding healthy tissue. The gel can be administered through various methods, including syringe, laparoscope, and bronchoscope, and is intended to improve the overall efficacy of thermal ablation therapies while enabling personalized treatment approaches.

Cordance Medical is a medical device company that develops radical therapy for a variety of CNS pathology, including primary and metastatic cancer, Alzheimer's, and Parkinson's diseases.

Access Airways provides intubation-delivering devices that reduce risk and win confidence in clinicians and patients. They designed it to provide safer, quicker, and less harmful procedures with its intuitive capabilities and added functionality. They improve the time to intubate and reduce failed intubation attempts.

Cogwear is a brain technology company focused on addressing the needs of individuals suffering from anxiety and depression. The firm is developing a next-generation wearable device that enhances traditional physical measurements by integrating cognitive and emotional insights. This innovation aims to transition brain monitoring from laboratory settings to everyday life, providing users with real-time access to clinical-grade cognitive and emotional data. Utilizing AI-powered algorithms and proprietary dry electroencephalography (EEG) sensors, the wearable comfortably and accurately measures brain activity. The device captures and analyzes brainwaves, enabling users to receive feedback on their mental state through a secure app and shareable dashboard. By unlocking valuable insights into brain health, Cogwear aspires to improve individual well-being and performance.

Current Surgical is a surgical device company founded in 2020 and headquartered in Washington, DC. The company specializes in developing advanced tools aimed at the treatment of solid tumors. Its flagship product is a smart surgical needle designed for minimally invasive tumor detection and ablation. This innovative needle utilizes real-time X-ray guidance and ultrasound energy to effectively heat and destroy tumors while preserving surrounding vital organs and tissue. By enabling surgeons to target tumors located near critical anatomy, Current Surgical aims to enhance surgical precision and improve patient outcomes.

Winter Innovations is a medical device company based in Knoxville, TN, focused on enhancing patient outcomes following orthopedic injuries. Founded in 2018, the company is currently developing EasyWhip, a patent-pending suturing needle specifically designed for orthopedic ligament and tendon reconstruction surgeries. This innovative device aims to simplify and standardize the whip stitching process, providing surgeons with improved ease of use, speed, stability, and versatility. By streamlining these procedures, Winter Innovations seeks to enhance the efficiency and consistency of orthopedic reconstruction, ultimately benefiting both surgeons and patients.

Oculomotor Technologies offers a vision therapy tool for optometry practices to treat convergence insufficiency and other vergence disorders.

Galaxy Therapeutics provides neurovascular devices that increase the rate of curing the disease and offer easy deployment, fluoroscopic visualization, and treatment for shallow or large aneurysms, enabling patients to avail improved medical treatment.

Kepley BioSystems is focused on developing innovative technologies aimed at addressing significant challenges in both marine and healthcare sectors. The company offers ocean restorative technology designed to combat the depletion of wild fish populations, promoting sustainable practices in marine ecosystems. Additionally, Kepley BioSystems is advancing life science solutions that provide accurate methods for testing dangerous endotoxins. Their platform focuses on healthcare innovations, specifically in the detection of blood-borne pathogens, enabling physicians to deliver rapid and sensitive diagnostics for bloodstream infections. Through these efforts, Kepley BioSystems aims to contribute to environmental sustainability and improve health outcomes.

Cartilage is a company based in Irvine, California, founded in 2019, that focuses on developing tissue-engineered products for the regeneration of cartilage. The company addresses both focal and large cartilage defects by utilizing a viscous injectable solution designed to enhance cartilage integration. This innovative approach aims to treat early signs of cartilage injury, allowing patients to heal effectively without the limitations associated with existing treatment options.

BondTrue LLC, a medical device company, announces the receipt of a Phase II Maryland Industrial Partnerships (MIPS) award from the Maryland Technology Enterprise Institute, a unit of the A. James Clark School of Engineering at the University of Maryland. The joint grant, worth $100,000, will be used for continuing development and research on the company’s patented device (#9,408,672), which aims to automate the process of surgical incisions and closures. The MIPS program supports the development and commercialization of products and processes in Maryland through industry/university research partnerships. MIPS provides funds, matched by participating companies, to fund the research. After successfully completing Phase I, BondTrue plans to refine developed prototype designs, which will be used in research and testing.

Instapath Inc. is a New Orleans-based company that designs and develops advanced microscopy systems for the imaging of cancer biopsies. Founded in 2017, its technology enables rapid on-site evaluation of biopsy samples at sub-cellular resolution, which aids in providing accurate diagnoses while preserving tissue for future analysis. This innovative approach addresses a significant issue in the healthcare industry, where over 7 million Americans undergo biopsy procedures annually, and approximately 20% of these fail to yield accurate results. By improving diagnostic accuracy and reducing the need for repeat procedures, Instapath's system enhances operating room efficiency and contributes to increased hospital revenue. The company also offers a mobile application for image viewing and annotation, facilitating centralized remote pathology evaluations and ensuring quality in biopsy assessments.

Active Therapy Systems develops an interactive exercise platform to deliver in-home therapies to people living with Parkinson's disease. The company was founded in 2017 and is headquartered in Nicholasville, Kentucky.

Oncospace, Inc. is a medical technology company founded in 2018 and based in Baltimore, Maryland, specializing in personalized medicine for radiation oncology. It has developed an AI-powered platform that leverages clinical treatment data to create optimized treatment plans tailored to individual patients. This platform aims to enhance patient outcomes by minimizing side effects and improving the overall quality of life. Through the use of machine learning, Oncospace's technology establishes best-practice dosimetric goals, facilitating better planning and evaluation in radiation therapy. The company focuses on fostering collaborative relationships within the medical community, thereby advancing the field of radiation oncology.

Rhaeos is a pioneering company that has developed the first wearable shunt monitor to enhance care for patients with hydrocephalus. Utilizing a novel thermal biosensor, the device allows for noninvasive, real-time monitoring of cerebrospinal fluid flow. This innovative technology, born from collaborative research at Northwestern University involving experts from engineering, medicine, and management, addresses a significant clinical need by providing timely data to improve treatment for chronic medical conditions. Rhaeos's patches are designed to detect fluid flow in various bodily systems, including blood and lymph, facilitating quicker medical responses and advancing the standard of care in neurosurgery and beyond.

Levaté designs a lightweight wheelchair. This lightweight wheelchair accessory restores reach and independence, giving people the flexibility to work, play, and love in their daily lives. The lift attaches and detaches quickly from the wheelchair and raises to eye level or any height in between to improve vision and reach in any environment - high shelves at the grocery store, the refrigerator or cabinets at home, gas stations, public restrooms, car transfers, shopping.

Sperry Bio is focused on developing innovative medical devices, particularly the sperry micro-coring system, aimed at treating burns and enhancing wound healing while minimizing scarring. The company is engaged in research programs aligned with the objectives of the army medical research and materiel command, specifically within the clinical and rehabilitative medicine research domain. By creating advanced skin graft harvesting technologies, Sperry Bio seeks to alleviate the pain and limitations associated with existing treatment methods, addressing functional impairments caused by severe scarring and contraction. Their approach aims to improve both the effectiveness of burn injury treatments and the cosmetic outcomes for patients.

ReSuture is a company that specializes in creating high-fidelity physical simulations for surgical training, particularly focusing on open vascular procedures. Established in 2019, its primary goal is to enhance patient outcomes and minimize surgical complications by providing a superior training experience for aspiring surgeons. The company develops advanced surgical instruments that address challenges in medical simulation, allowing users to practice vascular surgical skills in a controlled environment. These instruments replicate the mechanical properties of human vascular tissue, enabling realistic simulations that improve psychomotor skills and reduce training time for medical practitioners.

Modular Matter is a company that specializes in developing innovative prosthetic systems designed to enhance mobility, strength, comfort, and confidence for individuals with limb differences. Founded by Jeff Gair, the company focuses on creating a prosthesis that conforms to the unique shape of each individual's residual limb, ensuring a secure and comfortable fit. This adaptable solution is suitable for patients of all ages and accommodates various limb shapes, making it applicable for both upper and lower limb sockets. By prioritizing a personalized approach, Modular Matter aims to facilitate quicker recovery and improve the overall quality of life for its users.

NeuroDyn develops neurological devices that alleviate seizure activity in children who suffer from congenital brain disease, adults with seizure activity, and veterans who suffer brain damage, enabling the medical community to ensure relief for those who suffer from debilitating seizure effects.

Ramona develops advanced microscopy tools designed to enhance cellular-level research by capturing detailed images over vast areas. The company's innovative microscope employs custom control electronics to efficiently process large volumes of image data from multiple micro-cameras, allowing researchers to capture and analyze extensive gigapixel datasets. This capability not only provides a wider field of view but also enables synchronous data capture, allowing for real-time observation of cellular processes. By offering a new perspective on cellular dynamics, Ramona's technology empowers researchers to make more informed decisions quickly and effectively.

O2M Technologies develops oxygen imaging devices for effective cancer and regenerative medicine treatments. The company was founded in 2017 and is headquartered in Chicago, Illinois.

BioAesthetics LLC, founded in 2015 as a spin-out from Tulane University, is focused on developing innovative reconstruction options for breast cancer patients following mastectomies. The company specializes in a tissue-engineered nipple-areolar complex (NAC) that serves as an acellular graft to be used by plastic and reconstructive surgeons during the breast reconstruction phase. This product allows the patient's own cells to integrate with the graft, facilitating the regeneration of a natural nipple and areola. Currently in the pre-clinical phase, this patent-pending technology aims to provide a more effective and aesthetically pleasing solution for patients who have experienced incomplete or removed NACs due to illness, surgery, or congenital conditions. BioAesthetics is headquartered in Research Triangle Park, North Carolina.

RadWave Technologies Inc., founded in 2018 and based in Saint Paul, Minnesota, operates within the healthcare sector, specializing in the development of advanced technologies for minimally invasive medical procedures. The company has designed an electromagnetic navigation system that provides accurate object tracking for surgical applications. This system enhances the performance of image-guided, minimally invasive, and robotic procedures by enabling medical professionals to precisely locate surgical instruments and tools within the human body, even in areas lacking direct visibility.

Lasarrus develops devices for patients with chronic obstructive pulmonary disease. The company was founded in 2013 and is headquartered in Baltimore, Maryland.

BondTrue LLC, a medical device company, announces the receipt of a Phase II Maryland Industrial Partnerships (MIPS) award from the Maryland Technology Enterprise Institute, a unit of the A. James Clark School of Engineering at the University of Maryland. The joint grant, worth $100,000, will be used for continuing development and research on the company’s patented device (#9,408,672), which aims to automate the process of surgical incisions and closures. The MIPS program supports the development and commercialization of products and processes in Maryland through industry/university research partnerships. MIPS provides funds, matched by participating companies, to fund the research. After successfully completing Phase I, BondTrue plans to refine developed prototype designs, which will be used in research and testing.

TEGA was founded to exploit glycoscience-related technologies for the treatment of life-threatening diseases. Glycans, or complex carbohydrates, play important roles in many physiological and pathophysiological processes, but their value as pharmaceutical targets remains underexploited by industry. TEGA specializes in the science of glycans. The TEGA pipeline includes two major programs: glycoside-enhanced lysosomal delivery of proteins and recombinant production of heparan sulfate and heparin. They aim to improve quality of life for patients by enabling delivery of lifesaving treatments for unmet medical needs. Their work is motivated by a commitment to innovation and helping patients. They combine their powerful insights and rigorous scientific methods to help pharmaceutical companies overcome the obstacle of the blood-brain barrier.

Claria Medical is a pre-commercial medical device start-up focused on developing innovative solutions for women's healthcare, specifically targeting unmet needs in gynecologic surgery. The company specializes in creating minimally invasive surgical tools designed to enhance procedures such as hysterectomy and myomectomy. Claria Medical has received recognition for its early achievements, including a “Safer Technologies Designation” from the U.S. Food and Drug Administration. Additionally, the company has secured funding through private investments as well as grants from the National Science Foundation and the National Institutes of Health to support its product development efforts. By providing specialized surgical assistance, Claria Medical aims to improve outcomes for women undergoing these procedures.

Starling Medical focuses on creating a remote patient monitoring platform that facilitates at-home urine diagnostics, integrating seamlessly into everyday bathroom routines. The company is developing a healthcare device that employs mass spectroscopy-based sensors to continuously monitor changes in urine composition. This technology aims to enable early detection of chronic health issues, allowing both patients and healthcare providers to intervene promptly and potentially prevent serious complications or hospitalizations. By offering predictive insights, Starling Medical aspires to enhance health outcomes through proactive monitoring.

FloBio develops point-of-care diagnostics for bleeding risk based on real-time blood analysis. The company was founded in 2017 and is headquartered in Philadelphia, PA.

Relavo, LLC, founded in 2018 and based in Baltimore, Maryland, is a medical device company focused on improving the treatment of kidney failure patients through innovative technology. The company's flagship product, PeritoneX, is designed to enhance home dialysis by reducing the risk of infection associated with peritoneal dialysis. This in-line connection device works by disinfecting all connection points in the dialysis system before treatment, thereby aiming to minimize the occurrence of peritonitis. Relavo's approach seeks to make home dialysis safer and more accessible for patients, ultimately improving their quality of life.

Dynamic Entropy Technology is a manufacturer of medical devices focused on advancing health sciences through innovative technologies. Founded in 2018 and based in Pasco, Washington, the company specializes in developing a novel collagen citrate-based polymer biomaterial. This unique material is designed to address complex diabetic skin wounds, aiming to alleviate the health burden associated with conditions like diabetic foot ulcers. By enabling the effective delivery of drugs or biologics to these wounds, Dynamic Entropy Technology seeks to enhance healing outcomes for patients and improve their overall quality of life.

Emanate Wireless specializes in developing solutions that monitor the operation and productivity of clinical assets within healthcare facilities. By utilizing intelligent, cloud-connected sensors, the company's devices track the usage, utilization, and maintenance of healthcare equipment. This approach addresses the complexities associated with managing assets that are frequently in motion or in use, ultimately enhancing productivity and safety while ensuring compliance with healthcare standards. Emanate Wireless's focus on optimizing asset management helps to alleviate staff stress and improve operational efficiency in the healthcare sector.

Lapovations is a healthcare company founded in 2016 and headquartered in Fayetteville, Arkansas. It focuses on the development and manufacturing of innovative medical devices specifically designed for laparoscopic surgery. The company's mission is to redefine laparoscopy by creating devices that minimize invasiveness, simplify surgical procedures, and enhance patient outcomes. Through its cutting-edge technology, Lapovations aims to enable medical professionals to perform surgeries with greater safety and efficiency.

Digitouch Health is a U.S.-based company located in Valhalla, New York, that specializes in the development of a smartphone device for monitoring blood pressure. This innovative medical device utilizes algorithm-enabled technology and oscillometry to measure hypertension accurately without the need for calibration. It allows users to conveniently track and transmit their blood pressure readings to electronic health records, facilitating better management of cardiovascular health. By collaborating with healthcare practitioners, Digitouch Health aims to help individuals lead longer and healthier lives through effective monitoring and management of their blood pressure.

Thermaquil, Inc. is a Philadelphia-based company founded in 2017 that specializes in the development and sale of medical devices aimed at managing pain and other conditions linked to overactive nerves. The company is focused on creating an innovative reversible nerve block device designed to alleviate severe pain without the use of drugs or electrical stimulation, while also ensuring that no nerve damage occurs. This device is intended to provide relief to millions of individuals suffering from chronic pain, muscle spasms, and related ailments, thereby improving their quality of life.

Cactus Medical provides physicians with a standardized method for evaluating middle ear effusion. The company was founded in 2017 and is headquartered in Irvine, California.

ZeoVation Inc., founded in 2016 and located in Columbus, Ohio, specializes in the production of nanozeolites and hierarchical zeolites. These advanced materials are designed to enhance a variety of consumer products, including skin care lotions, sunscreens, and laundry detergents, by improving the efficiency of water softeners and filtration systems. ZeoVation also supplies zeolite materials to various markets such as sun and skin care, home care, healthcare, coatings, and water and gas purification. The company focuses on developing innovative solutions, including a controlled-release antimicrobial and antiviral particle that can be integrated into various applications like sprays, coatings, and textiles. This technology aims to combat the spread of antibiotic-resistant bacteria and viruses, including SARS-CoV-2, thereby contributing to safer and cleaner products.

Intake Health is a developer of a continuous passive health monitoring device that operates at home without requiring changes in user behavior. The device is designed to be mounted on a toilet, where it automatically tests urine from flush water to deliver lab-quality results for various health and dietary indicators. By leveraging advanced biosensors and wireless technology, the system accurately tracks hydration and nutrition by quantifying specific urinary biomarkers. Users receive instant insights on their health metrics through a mobile application, facilitating informed decision-making regarding their well-being. Intake Health aims to enhance health predictions and personalized prevention strategies through the accumulation of personalized biomarkers over time. The company has received funding from the National Science Foundation and the National Institutes of Health.

Marani Health is focused on advancing prenatal care through the development of a wearable, textile-based technology that monitors key vital statistics for women and their developing fetuses during pregnancy, labor, and delivery. By leveraging artificial intelligence, Marani's product provides timely and accurate data, enhancing the assessment of maternal and fetal health. The company collaborates with prominent partners, including The Mayo Clinic, to improve health outcomes for mothers and their babies.