National Science Foundation

The National Science Foundation (NSF) is an independent federal agency established in 1950 and based in Alexandria, Virginia. It is dedicated to supporting research and education in science and engineering across a wide range of disciplines. The NSF provides significant non-dilutive funding, up to $1.5 million, to startups and small businesses through its America's Seed Fund initiative, which is part of the Small Business Innovation Research (SBIR) program mandated by Congress. With an operating budget of approximately $7.8 billion, the NSF is committed to advancing fundamental research and education, thus fostering innovation and technological development in the United States.

James Donlon

Program Director

Debasis Majumdar

Program Director

Graciela Narcho

Staff Associate

Sethuraman Panchanathan

Director

Past deals in Cosmetics

Superior Nano

Grant in 2022
Superior Nano specializes in the development and manufacturing of topical skincare products that leverage advanced nanotechnology. The company's offerings include serums and moisturizers designed to enhance skin appearance and health. These products combine multiple anti-aging ingredients into a single formulation, effectively targeting concerns such as fine lines, wrinkles, age spots, and overall skin firmness. By utilizing this innovative approach, Superior Nano aims to provide consumers with effective solutions for achieving a more radiant complexion without resorting to invasive procedures.

HairDays

Grant in 2022
HairDays is an AI-powered health data company that has developed a unique hair intelligence platform focused on simplifying hair classification and care. The platform provides tailored recommendations for maintaining healthy hair, allowing consumers to discover and purchase hair care products suited to their individual needs. By curating relevant content, HairDays enables users to monitor their hair conditions and track their growth progress effectively. This innovative approach eliminates the guesswork often associated with hair care, empowering individuals to make informed decisions about their hair health.

SunFly Brands

Grant in 2021
SunFly Brands, Inc. is a Seattle-based company that specializes in developing innovative solutions to improve sunscreen application and enhance sun safety. Founded in 2016, the company creates invisible ink stamps and ultraviolet indicator stamps designed to be worn under sunscreen. These stamps change color to signal users when it is time to reapply sunscreen, addressing a critical issue where many individuals apply only a third of the recommended amount and fail to reapply frequently enough. This behavior contributes to excessive UV exposure, leading to sunburns, skin cancers, and premature skin aging. With skin cancer being the most prevalent cancer in the U.S., SunFly Brands aims to raise awareness and encourage safer sun practices through their unique products.

Seaspire Skincare

Grant in 2021
Seaspire Skincare specializes in the development and manufacturing of multifunctional colorants and active ingredients derived from oceanic biodiversity. The company focuses on creating innovative solutions to address chronic and cosmetic hair and skin conditions while aiming to replace harmful components in traditional sunscreens. One of its key products features the biomolecule Xanthochrome, which provides enhanced protection against a wider spectrum of ultraviolet radiation compared to existing physical and chemical filters. This technology is designed for preventative skincare, promoting a healthier approach that minimizes adverse effects on both human and marine health. Through its sustainable and less toxic formulations, Seaspire Skincare contributes to advancing the skincare industry towards safer and environmentally friendly practices.

Ubiros

Grant in 2020
Ubiros specializes in the production of food-grade robotic grippers designed for automation in the food and beverage, cosmetics, and pharmaceutical sectors. Their innovative electrically actuated soft grippers, such as the gentle flex module, gentle duo, and gentle pro, enable precise handling of fragile objects without causing damage. These grippers operate without an external air source, which reduces costs, complexity, and noise typically associated with traditional pneumatic or vacuum systems. By utilizing materials like polyurethane, Ubiros provides effective control over gripping force and movement, facilitating the automation of material handling in non-traditional industries.

ZeoVation

Grant in 2020
ZeoVation Inc., founded in 2016 and located in Columbus, Ohio, specializes in the production of nanozeolites and hierarchical zeolites. These advanced materials are designed to enhance a variety of consumer products, including skin care lotions, sunscreens, and laundry detergents, by improving the efficiency of water softeners and filtration systems. ZeoVation also supplies zeolite materials to various markets such as sun and skin care, home care, healthcare, coatings, and water and gas purification. The company focuses on developing innovative solutions, including a controlled-release antimicrobial and antiviral particle that can be integrated into various applications like sprays, coatings, and textiles. This technology aims to combat the spread of antibiotic-resistant bacteria and viruses, including SARS-CoV-2, thereby contributing to safer and cleaner products.

Benanova

Grant in 2020
Benanova specializes in developing environmentally benign nanoparticle systems for various industries, including disinfectants, cosmetics, and agriculture. The company's innovative Environmentally-benign Nanoparticles (EbNPs) are crafted from natural materials, offering high efficacy while being safe for both humans and the environment. These proprietary nanoparticles are reportedly 100 times more effective than traditional nanosilver, positioning them as advanced alternatives for antimicrobial and antifungal applications. Benanova is also working on customized solutions aimed at reducing chemical use in agricultural practices by up to 90%, thus minimizing environmental impact and costs associated with crop protection. The technology behind these products was developed by researchers at North Carolina State University, and the focus on sustainable, advanced functionality reflects Benanova's commitment to creating lasting benefits for consumers, society, and nature.

Spira

Grant in 2020
Spira focuses on developing algae-based ingredients designed to replace petroleum and animal-derived compounds, promoting sustainability in various industries. The company specializes in creating food-safe dyes and other industrial ingredients, which are utilized across sectors such as beverages, cosmetics, textiles, and confectionery. By collaborating with a global network of farming partners, Spira aims to manufacture raw materials that contribute to carbon capture and wastewater management. Their efforts not only support the transition to more sustainable materials but also assist in improving the livelihoods of farmers in developing countries. Through its innovative products and services, Spira is committed to enhancing both human and planetary health.

Benanova

Grant in 2020
Benanova specializes in developing environmentally benign nanoparticle systems for various industries, including disinfectants, cosmetics, and agriculture. The company's innovative Environmentally-benign Nanoparticles (EbNPs) are crafted from natural materials, offering high efficacy while being safe for both humans and the environment. These proprietary nanoparticles are reportedly 100 times more effective than traditional nanosilver, positioning them as advanced alternatives for antimicrobial and antifungal applications. Benanova is also working on customized solutions aimed at reducing chemical use in agricultural practices by up to 90%, thus minimizing environmental impact and costs associated with crop protection. The technology behind these products was developed by researchers at North Carolina State University, and the focus on sustainable, advanced functionality reflects Benanova's commitment to creating lasting benefits for consumers, society, and nature.

HelioBioSys

Grant in 2020
HelioBioSys is a biotechnology company that specializes in marine cyanobacteria. The company uses marine cyanobacteria that grow on air, seawater, and sunlight. They produce a variety of complex biopolymers. HelioBioSys has developed cost-effective ways to harvest and process them into concentrated polysaccharides and hydrogels. These sustainably-derived biomaterials have applications in cosmetics, sunscreens and bioplastics.

GlycoSurf

Grant in 2019
GlycoSurf, established in 2013, is a specialty chemicals company that produces bio-inspired surfactants, specifically focusing on rhamnolipids. These are high-purity, non-toxic, biodegradable glycolipids with tailored chemical properties. GlycoSurf's products are used in various applications, notably in the formulation of personal-care products, contributing to a more sustainable chemical industry.

Bluelene

Grant in 2019
Bluelene is an online retailer specializing in face care products that focus on anti-aging and skin health. The company utilizes a patented ingredient, methylene blue, which penetrates human cells to enhance mitochondrial function. This innovative approach not only improves overall skin health but also aids in repairing aging damage and protecting against sun exposure. Bluelene's formulations are designed to extend the lifespan of skin cells, thereby promoting better connective tissue and facilitating wound healing. Their products cater to both men and women, offering effective solutions for maintaining healthy skin.

ZeoVation

Grant in 2019
ZeoVation Inc., founded in 2016 and located in Columbus, Ohio, specializes in the production of nanozeolites and hierarchical zeolites. These advanced materials are designed to enhance a variety of consumer products, including skin care lotions, sunscreens, and laundry detergents, by improving the efficiency of water softeners and filtration systems. ZeoVation also supplies zeolite materials to various markets such as sun and skin care, home care, healthcare, coatings, and water and gas purification. The company focuses on developing innovative solutions, including a controlled-release antimicrobial and antiviral particle that can be integrated into various applications like sprays, coatings, and textiles. This technology aims to combat the spread of antibiotic-resistant bacteria and viruses, including SARS-CoV-2, thereby contributing to safer and cleaner products.

HelioBioSys

Grant in 2018
HelioBioSys is a biotechnology company that specializes in marine cyanobacteria. The company uses marine cyanobacteria that grow on air, seawater, and sunlight. They produce a variety of complex biopolymers. HelioBioSys has developed cost-effective ways to harvest and process them into concentrated polysaccharides and hydrogels. These sustainably-derived biomaterials have applications in cosmetics, sunscreens and bioplastics.

Benanova

Grant in 2018
Benanova specializes in developing environmentally benign nanoparticle systems for various industries, including disinfectants, cosmetics, and agriculture. The company's innovative Environmentally-benign Nanoparticles (EbNPs) are crafted from natural materials, offering high efficacy while being safe for both humans and the environment. These proprietary nanoparticles are reportedly 100 times more effective than traditional nanosilver, positioning them as advanced alternatives for antimicrobial and antifungal applications. Benanova is also working on customized solutions aimed at reducing chemical use in agricultural practices by up to 90%, thus minimizing environmental impact and costs associated with crop protection. The technology behind these products was developed by researchers at North Carolina State University, and the focus on sustainable, advanced functionality reflects Benanova's commitment to creating lasting benefits for consumers, society, and nature.

Manus Bio

Grant in 2017
Manus Bio Inc. is a biotechnology company that specializes in recreating plant processes in microorganisms to produce natural ingredients through advanced fermentation technology. Founded in 2011 and based in Cambridge, Massachusetts, the company utilizes a combination of metabolic engineering, protein engineering, and systems biology to develop microbes capable of generating a variety of plant-based ingredients. These ingredients have diverse applications, including flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals, and agricultural chemicals. Manus Bio operates manufacturing facilities in Cambridge and Augusta, Georgia, and has established a strategic partnership with BBGI Public Company Limited. The company was previously known as Manus Biosynthesis, Inc. before changing its name in June 2018.

Arch Innotek

Grant in 2017
Arch Innotek, LLC is a biotechnology company based in St. Louis, Missouri, focused on engineering microorganisms to produce natural ingredients that promote health for both humans and animals. Established in 2013, the company specializes in the fermentation of yeast to generate natural carotenoid antioxidants and other high-value molecules for the food, feed, pharmaceutical, and cosmetics industries. Arch Innotek employs sustainable and cost-effective fermentation processes to develop innovative technologies that provide healthier alternatives for consumers. Additionally, the company offers a range of scientific services, including HPLC analysis, LC-MS analysis, protein purification, and molecular cloning, to support its research and development efforts.

Renuvix

Grant in 2016
Renuvix is a manufacturer of bio-based resins and polymers, catering to formulators in various industries including paints, coatings, composites, adhesives, cosmetics, and personal care products. Founded in 2013 and headquartered in Fargo, North Dakota, the company focuses on developing innovative resin and synthetic rubber solutions. Renuvix's products enable formulators to achieve lower volatile organic compound emissions in paints and coatings, while also enhancing the performance characteristics of thermosets through high cross-link density.

Phytoption

Grant in 2016
Phytoption LLC, founded in 2011 and based in West Lafayette, Indiana, specializes in developing biopolymers derived from phytoglycogen. The company focuses on producing natural ingredients and sustainable materials from agricultural commodities for various sectors, including pharmaceuticals, agriculture, cosmetics, and food and beverage. Phytoption's products aim to enhance product shelf life, sensory properties, bioavailability, functionality, and nutritional value. By addressing solubility challenges, the company supports its clients in the personal care, agricultural, and food industries. Inquiries from customers can be managed through phone, email, and online platforms.

The Actives Factory

Grant in 2015
The Actives Factory is a wholesale supplier of natural actives and compounds. They provide cosmetics care, personal care, pharmaceutical drugs, and research dietary supplements. The birch tree is a source of their natural triterpenes compounds such as betulin, betulinic acid, lupeol, and betulin caffeates.

ATRP Solutions

Grant in 2014
ATRP SOLUTIONS develops and manufactures specialty polymers that meet their needs. It recognizes the polymeric materials for improving the performance of commercial products in the areas of personal care and cosmetics, detergents and surfactants, paints, pigments, coatings, and biocompatible materials. It was founded in 2006 and is headquartered in Pittsburgh, Pennsylvania.

Renuvix

Grant in 2014
Renuvix is a manufacturer of bio-based resins and polymers, catering to formulators in various industries including paints, coatings, composites, adhesives, cosmetics, and personal care products. Founded in 2013 and headquartered in Fargo, North Dakota, the company focuses on developing innovative resin and synthetic rubber solutions. Renuvix's products enable formulators to achieve lower volatile organic compound emissions in paints and coatings, while also enhancing the performance characteristics of thermosets through high cross-link density.

Phytoption

Grant in 2013
Phytoption LLC, founded in 2011 and based in West Lafayette, Indiana, specializes in developing biopolymers derived from phytoglycogen. The company focuses on producing natural ingredients and sustainable materials from agricultural commodities for various sectors, including pharmaceuticals, agriculture, cosmetics, and food and beverage. Phytoption's products aim to enhance product shelf life, sensory properties, bioavailability, functionality, and nutritional value. By addressing solubility challenges, the company supports its clients in the personal care, agricultural, and food industries. Inquiries from customers can be managed through phone, email, and online platforms.

OmegaChea

Grant in 2013
OmegaChea is a biotechnology company that creates a scalable technology based on microbial engineering to generate bio-based specialty chemicals such as lubricants, surfactants, cosmetics and pharmaceutical products.

Manus Bio

Grant in 2013
Manus Bio Inc. is a biotechnology company that specializes in recreating plant processes in microorganisms to produce natural ingredients through advanced fermentation technology. Founded in 2011 and based in Cambridge, Massachusetts, the company utilizes a combination of metabolic engineering, protein engineering, and systems biology to develop microbes capable of generating a variety of plant-based ingredients. These ingredients have diverse applications, including flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals, and agricultural chemicals. Manus Bio operates manufacturing facilities in Cambridge and Augusta, Georgia, and has established a strategic partnership with BBGI Public Company Limited. The company was previously known as Manus Biosynthesis, Inc. before changing its name in June 2018.

ChromaDex

Grant in 2013
ChromaDex Corporation is a global nutraceutical company based in Los Angeles, California, focused on promoting healthy aging through innovative ingredient technologies. The company is best known for its flagship product, Nicotinamide riboside (NIAGEN), a patented form of vitamin B3 that enhances nicotinamide adenine dinucleotide (NAD+) levels, which naturally decline with age. In addition to NIAGEN, ChromaDex offers Immulina, a spirulina extract designed to improve immune function. The company operates through three main segments: Consumer Products, Ingredients, and Analytical Reference Standards and Services, with the majority of its revenue generated from the Consumer Products segment. ChromaDex markets its products directly in the United States and Canada, while also utilizing international distributors, and employs in-house expertise in chemistry, regulatory affairs, and safety consulting to develop commercially viable ingredients across various industries, including dietary supplements, food, beverage, skin care, and pharmaceuticals.

EigenChem Technologies

Grant in 2013
EigenChem Technologies, founded in 2011 in Alachua, Florida, specializes in chemistry and process research, focusing on synthetic organic chemistry projects. The company offers a range of services, including custom synthesis, analytical research, and the design and synthesis of biologically active compounds, drug candidates, cosmetic ingredients, and dietary supplements. EigenChem Technologies aims to develop innovative solutions for the cleantech and biotech sectors, enabling clients to enhance their research and products through advanced chemical processes. The company's expertise also includes integrating nitrogen and micronutrient sources with water-absorbing and soil-structure improving properties.

Manus Bio

Grant in 2012
Manus Bio Inc. is a biotechnology company that specializes in recreating plant processes in microorganisms to produce natural ingredients through advanced fermentation technology. Founded in 2011 and based in Cambridge, Massachusetts, the company utilizes a combination of metabolic engineering, protein engineering, and systems biology to develop microbes capable of generating a variety of plant-based ingredients. These ingredients have diverse applications, including flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals, and agricultural chemicals. Manus Bio operates manufacturing facilities in Cambridge and Augusta, Georgia, and has established a strategic partnership with BBGI Public Company Limited. The company was previously known as Manus Biosynthesis, Inc. before changing its name in June 2018.

ATRP Solutions

Grant in 2012
ATRP SOLUTIONS develops and manufactures specialty polymers that meet their needs. It recognizes the polymeric materials for improving the performance of commercial products in the areas of personal care and cosmetics, detergents and surfactants, paints, pigments, coatings, and biocompatible materials. It was founded in 2006 and is headquartered in Pittsburgh, Pennsylvania.

SyntheZyme

Grant in 2012
SyntheZyme is a privately held sustainable chemical company based in Rensselaer, New York, that focuses on developing bio-based industrial chemicals to replace petrochemical-derived substances. Founded on the research of Professor Richard A. Gross, the company leverages biocatalysis to create biodegradable alternatives for various applications, including plastics, pesticides, cosmetics, and personal care products. By utilizing nature's chemistry, SyntheZyme aims to provide environmentally friendly solutions that contribute to a more sustainable chemical industry.

Manus Bio

Grant in 2012
Manus Bio Inc. is a biotechnology company that specializes in recreating plant processes in microorganisms to produce natural ingredients through advanced fermentation technology. Founded in 2011 and based in Cambridge, Massachusetts, the company utilizes a combination of metabolic engineering, protein engineering, and systems biology to develop microbes capable of generating a variety of plant-based ingredients. These ingredients have diverse applications, including flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals, and agricultural chemicals. Manus Bio operates manufacturing facilities in Cambridge and Augusta, Georgia, and has established a strategic partnership with BBGI Public Company Limited. The company was previously known as Manus Biosynthesis, Inc. before changing its name in June 2018.
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