National Science Foundation

Amplified Sciences LLC is a molecular diagnostics company focused on the early detection of debilitating diseases, particularly pancreatic cancer and kidney disease. Utilizing an ultra-sensitive molecular sensing technology licensed from Purdue University, the company’s platform can detect disease markers at the single molecule level, enabling accurate diagnosis from bodily fluids such as urine and saliva. This versatile technology is designed for scalability to point-of-care applications, allowing for effective disease screening with a favorable cost structure. Amplified Sciences has developed a working prototype and has published proof of concept data, positioning itself to meet significant unmet medical needs in diagnostics. Founded in 2016 and based in West Lafayette, Indiana, the company was previously known as Nutrabiotix.

Serious research-based academics in Technology and the Engineering, Biological and Computer Sciences on a remodeled, state-of-the-art campus is what you will find at New Jersey Institute of Technology (NJIT) in Newark, New Jersey. Applied Physics, Biocomplexity, Biomedical Engineering, Civil Engineering, Mathematical Engineering and Medical Informatics Technology are some of the more than 70 undergraduate degrees offered at NJIT. There are also more than 15 graduate programs. Not only do nearly 100% of faculty hold doctorates, but they also work on pioneering research with students and with local businesses and organizations as well. Research areas include such fields as Biological Sciences, Biomedical Studies, Nanotechnologies and Wireless Communications. Opportunities for work abound for NJIT grads in great part because of the quality of student training and the reputation of the school. Also important are the internships, which the school arranges for students while they’re still studying. Classrooms and research centers aren’t the only place on the NJIT campus that employ the most current technologies. The renovated campus recreation areas, computer labs, and restaurants add to the contemporary look and feel of the NJIT experience. Since Newark is the largest city in New Jersey there are also many employment opportunities available in the area. With its restaurants and cultural activities, Newark also provides much in the way of recreation and culture. New York City is also only 20 minutes away, so there is even more to be found in the off-campus experience. Admission to NJIT is competitive and undergraduates who are accepted usually have high grades and test scores. Many eligible undergraduates receive some form of financial aid.

Remedium Bio is a Boston-based gene therapy company dedicated to developing curative treatments for various debilitating conditions. The company employs a modular approach to research and development, utilizing established technologies in innovative ways to address well-understood disease mechanisms. By focusing on clinically validated molecules and targeted treatment strategies, Remedium Bio aims to create effective therapies for conditions within rheumatology, endocrinology, and neurology. Its pipeline includes promising gene therapy candidates designed to tackle a wide range of diseases, including immune and age-related disorders.

Atom Bioworks focuses on developing a pattern-recognition enabled platform that combines DNA, antibody mimics, and advanced computational techniques for the detection and treatment of infectious diseases and cancer. The platform utilizes computational biology, quantum chemistry, software, and machine learning to identify specific surface protein patterns associated with diseases. By creating corresponding pattern-matching constructs, Atom Bioworks aims to enhance researchers' capabilities in early diagnosis and therapeutic interventions, ultimately improving medical applications in the fight against infectious diseases and cancer.

Bespoke Biotherapeutics provides an effective natural immune response and overcomes the limitations of currently approved immunotherapies against cancer by inventing novel, customised living drugs called engineered B-cell therapeutics. They offer customised B-cell sourcing, isolation, activation, culture expansion, and non-viral genetic engineering methodologies uniquely suited to optimise commercial B-cell products for infusion.

Tiny Cargo specializes in a unique drug delivery system utilizing non-immunogenic bovine milk-derived exosomes. This innovative approach allows for the effective oral or intravenous administration of potent therapeutics. The company focuses on delivering treatments for various serious health conditions, including ischemic heart disease, gastrointestinal radiation disease, and glioblastoma multiforme, among others. By leveraging its technology, Tiny Cargo aims to enhance the delivery of peptide drugs, making it applicable to a wide range of current peptide therapeutics and improving patient outcomes in the treatment of neurological and other pathologies.

OncoSTING, located in Baltimore, is developing novel bladder cancer therapies that work by combining the potency of standard BCG immunotherapy with long-lived delivery of potent STING agonists. (JHU)

Oculogenex is a biopharmaceutical company that specializes in gene therapy for the treatment of retinal disorders. The company was founded in 2020 and is headquartered in La Habra, California.

Qualia Oto is a biomedical device company focused on advanced cochlear implant technology. It utilizes its core innovations to produce top-quality, shape-changing polymers and matrix-addressed electrode arrays embedded in devices for individuals' medical and personal needs. The company's technology enables higher channel count cochlear implants and auditory brainstem implants for more precise auditory nerve stimulation and the eventual incorporation of more complex, machine learning-based stimulation. Qualia Oto was founded in 2017 in Dallas, TX.

Aqua Science offers a global platform of technologies and fast and reliable solutions for the testing and treatment of water. They provide research and development, custom reagent and kit manufacture, product assembly, lyophilization services, and contract manufacturing services.

Oxalo Therapeutics is focused on developing innovative drug therapies aimed at treating rare kidney diseases and preventing recurring kidney stones. The company specifically targets primary hyperoxaluria and other oxalate-related pathologies through a novel approach that utilizes a gut bacterium to facilitate the safe removal of oxalate from the body. By mimicking natural mechanisms, Oxalo Therapeutics seeks to provide effective treatment options for patients suffering from conditions associated with high levels of oxalate, thereby improving their quality of life and reducing the incidence of kidney stone recurrence. The company's expertise in the microbiome and translational research underpins its commitment to advancing early-stage technology in the field of kidney health.

Uniphage is a biotech company that eliminates bacterial infections by combining the power of bacteriophages with artificial intelligence. Their first target disease is citrus greening, an incurable and debilitating disease that costs the United States more than $2 billion each year. Uniphage created the first commercially effective models for computationally predicting safe bacterial viruses against target bacterial infections, as well as discovered a variety of targets. This enables them to deliver new antimicrobial, safe, and precise products to market much more quickly.

Birch Biosciences focuses on developing a proprietary platform that engineers enzymes for an innovative and sustainable plastic recycling process. By utilizing artificial intelligence, bioinformatics, and high-throughput screening techniques, the company creates enzymes that naturally and efficiently break down plastics. This method stands out from traditional recycling by producing virgin-quality, environmentally sustainable, and cost-competitive recycled materials, thereby contributing to a circular plastics economy. Birch Biosciences aims to provide businesses with an effective solution for addressing plastic waste while ensuring economic viability.

ViQi offers software-as-a-service solutions for scientific image analysis, catering to various sectors including life sciences, construction, and agriculture. The platform enables users to customize services for data storage and analysis through a straightforward subscription model. ViQi specializes in custom image processing and informatics, providing tools such as bio-image semantic queries, module development, and assistance with intranet deployment. This allows clients to efficiently view, investigate, share, and store complex data and images, facilitating swift results and discoveries in their respective fields.

Simmbion specializes in innovative therapeutic solutions by utilizing symbionts to manufacture therapeutic agents directly within the human body, effectively transforming it into a living pharmacy. This technology aims to eliminate the challenges associated with traditional therapy manufacturing, such as the need for complex production processes, repeated injections, and temperature-sensitive storage. By providing a single injection that lasts up to 12 weeks, Simmbion's approach addresses supply chain disruptions and enhances affordability and accessibility of cell therapies for diverse patient populations. Their adaptable and universally immune compatible systems focus on delivering biological drugs directly in vivo, supporting a patient-centric and outcome-driven healthcare model while minimizing the risks of infections and immune rejection.

EzraBio provides quick and easy RNA adenylation technology, enabling ribosome profiling without limitations. They offer rapid cDNA library construction. They offer streamlined services from sample preparation to deep sequencing.

Creative BioTherapeutics is a biotechnology company dedicated to developing innovative therapies for cancer and viral diseases. The company aims to transform cancer and viral disease research by targeting the fundamental issues of immune evasion and drug resistance. With a focus on recurrent and drug-resistant cancers, Creative BioTherapeutics is creating first-in-class biologics designed to address critical needs in treatment, particularly for patients with recurrent metastatic breast cancer. This approach not only seeks to enhance tumor regression but also holds the potential for cures in both adult and childhood cancers, thereby improving treatment options for patients facing these challenging conditions.

PHAXTEC provides natural material solutions to serve the foodservice packaging, agriculture, and personal care industries. Their PHA biopolymers are biodegradable in soil, freshwater, and marine environments like cellulose or paper.

Cryptyx Bioscience is a genetics-free, cloning-free, bioactivity-first platform for accessing hidden therapeutic natural products encoded in bacteria. They utilize a natural product drug discovery platform aimed at activating silent biosynthetic gene clusters in bacteria and at unlocking the full potential of any culturable microbe.

PETL Fluidics operates a microfluidics platform designed for laboratory research. The company specializes in controlling, managing, and experimenting within microfluidic environments, facilitating a variety of applications such as chemical reactions, cell and organoid culture, advanced imaging, and mechanobiology. By providing custom-designed microfluidic solutions, PETL Fluidics aims to enhance the capabilities of laboratories engaged in cutting-edge scientific research.

Iaso Therapeutics, founded in 2018 and based in East Lansing, Michigan, is a biotechnology company focused on developing vaccines aimed at improving human health and treating infectious diseases. The company’s platform is dedicated to creating vaccines for serious illnesses, including smallpox, yellow fever, and tetanus. By providing healthcare professionals with innovative technologies, Iaso Therapeutics seeks to enhance public health outcomes and address critical health challenges.

Secure Food Solutions is a food safety company in Tennessee. They bring technologies to market for the rapid detection of toxins, pathogens and other contaminants in the world’s food supply. Their first technology is a patented imaging technology to detect corn contaminated with aflatoxin.

NanoResearch provides research, design, development, and commercialization of energy storage or smart materials, energy storage devices, mechanical smart lighting products, and nanobiomedical products for governments, businesses, and non-profit organizations.

Ummino offers precision fermentation technology for fortified food and beverage products. The company's technology unlocks rare compounds to transform commodity ingredients into high-value functional foods.

Lura Health has developed a groundbreaking non-invasive health monitoring platform that utilizes saliva as a diagnostic fluid, aiming to enhance clinical outcomes in chronic disease management. Founded in 2017 and based in Cambridge, Massachusetts, the company targets various chronic disease markets, including heart disease, chronic kidney disease, diabetes, and tooth decay. Its innovative sensors are integrated into patient-friendly orthodontic devices such as removable retainers and fixed braces. These sensors continuously measure analytes in saliva and automatically transmit data to a smartphone application, allowing users to track key diagnostic metrics related to their oral health. By enabling individuals to monitor their health in real-time, Lura Health seeks to improve personal health management and empower users to take charge of their well-being.

UCHU Biosensors develops a platform of tooth mounted sensors to effortlessly track health through saliva.

Stochastic Research Technologies specializes in delivering fundamental and applied research focused on algorithms, methods, and tools that address challenges in energy, environmental sustainability, molecular modeling, process management, supply chain management, and biomedical engineering. The company develops software solutions aimed at resolving complex issues in the chemical, pharmaceutical, and biomedical sectors. By leveraging modeling, optimization under uncertainty, and process control, Stochastic Research Technologies enables clients across various industries to access effective solutions tailored to their specific needs.

Renerva is a growing medical device company that specializes in the development and commercialization of implantable technologies designed to enhance peripheral nerve repair procedures. The company's products aim to facilitate nerve repair, recovery, and storage, focusing on improving patient outcomes and accelerating healing processes. By providing innovative surgical devices, Renerva enables healthcare professionals to effectively assist patients in regaining function following nerve injuries.

WIndow Therapeutics discovers and develops transformational therapeutics to address critical unmet patient needs in cancer and other life-threatening diseases. They develop breakthrough cancer therapeutics designed to penetrate and permeate into diseased tissue and exert activity specifically against cancer cells and not healthy ones.

Cytocybernetics is a biotechnology company that specializes in cellular electrophysiology. The company has developed the Cybercyte, a user-friendly plug-and-play dynamic clamp system designed for ease of use in research settings. In addition to its innovative products, Cytocybernetics offers a comprehensive range of contract research organization (CRO) services, which include FDA-mandated drug safety screening, custom electrophysiology, custom modeling, and custom analysis. These services are aimed at assisting clients in the development and evaluation of various cellular products, ensuring that they meet regulatory requirements and scientific standards.

Visicell Medical is a company focused on developing innovative medical imaging technology that enhances the early detection and diagnosis of diseases. It specializes in creating safe and biodegradable stem cell tracking tools, which facilitate real-time monitoring of stem cells implanted in patients. These tools are designed for use in both clinical and pre-clinical settings, allowing healthcare professionals to track stem cell progress effectively. In addition to stem cell tracking, Visicell Medical offers specialized image capture systems and analysis tools that provide high-resolution, three-dimensional views of tissues and cells. This technology aids in the identification of abnormalities, enabling earlier intervention and improved treatment outcomes for patients, while also aiming to reduce overall healthcare costs.

Amphix Bio is engaged in the development of advanced therapeutic materials aimed at regenerative medicine. The company specializes in creating nanofiber materials that replicate the structure and dynamic characteristics of human tissues. By integrating biological signals, these materials instruct cells to activate regenerative processes. Amphix Bio's innovations enable the development of therapies designed to repair a variety of tissues, including bone, cartilage, muscle, cardiovascular tissues, and the brain and spinal cord. The promising results observed in both preclinical and clinical trials highlight the potential of Amphix Bio's approach in transforming therapeutic applications in medicine.

Acrigen Biosciences is dedicated to making gene editing safe. It develops technologies to improve efficiency and enhance the safety of CRISPR-Cas based gene editing. CRISPR-Cas system which enables the precise enzymatic editing of genes is one of the most exciting and promising techniques to be developed in the last few years with the capability to prevent or cure many devastating diseases. It was founded in 2019 and is headquartered in Berkeley, California.

InvVax, Inc. is a vaccine development company based in Los Angeles, California, founded in 2012. The company focuses on creating innovative vaccines, with its primary product being a universal influenza vaccine aimed at preventing pandemics. Utilizing a proprietary platform, InvVax's technology analyzes influenza proteins to address virus mutations, thereby enhancing the effectiveness of vaccines. In addition to its work on influenza, InvVax is exploring vaccine candidates for other viral infections, including HIV, Hepatitis B, and Hepatitis C.

Bactana Corporation focuses on researching and developing nutritional products aimed at enhancing microbiome health in livestock and pets. The company has created a product platform called FPS-4, which leverages the beneficial interaction between an animal’s immune system and metabolism to boost productivity while ensuring good health. Bactana's approach includes identifying and isolating beneficial molecules from anaerobic bacteria found in the animal microbiome. The company also targets metabolic conditions and digestive disorders in pets, aiming to develop therapies for issues such as prediabetes and diabetes. Additionally, Bactana is committed to creating sustainable products that reduce the reliance on antibiotics and conserve natural resources in livestock production. Founded in 2016 and headquartered in Farmington, Connecticut, Bactana serves cattle farmers primarily in Connecticut and New York.

Isolere Bio is a biotechnology company dedicated to simplifying the purification of biotherapeutics, particularly monoclonal antibodies and Adeno-Associated Viruses (AAV). Co-founded with the aim of enhancing global access to essential drugs, Isolere Bio develops innovative manufacturing technologies that utilize a straightforward Tangential Flow Filtration (TFF) setup. This approach facilitates a seamless transition from laboratory-scale processes to large-scale industrial production, thereby improving efficiency within the bioprocessing industry. As monoclonal antibodies continue to gain prominence as effective therapeutics and important research tools, Isolere Bio's work plays a crucial role in advancing the development of new diagnostics and treatments.

Auctus Biologics is a pre-clinical biotechnology company that develops antibody mimetics for therapeutic and diagnostic applications.Antibodies are the most prolific biologics in clinical environments because of their ability to bind targets with high affinity and specificity. However, antibodies also carry liabilities. They are often unstable and require costly cold-chain management to reach their destinations in active form. Because of their fragility, antibodies typically cannot be used in extreme environments like the gastrointestinal tract and can require lengthy infusions to administer to patients.

OmicsCraft offers customers access to a customised data analytics pipeline and a sample-to-solution service. They offer cloud-based platforms that allow them to build analytics pipelines for omic data preprocessing, mass spectrometric-based metabolite identification, differential analysis of metabolite profiles, and multi-omics integration.

Pathotrak, LLC, founded in 2016 and based in College Park, Maryland, develops innovative food safety testing kits that significantly enhance the detection of food-borne pathogens, such as Salmonella and E. coli. Utilizing advanced microfiltration technology, Pathotrak's kits reduce the testing time from 1-2 days to just 6 hours, streamlining the traditional 22-hour enrichment process. This rapid detection capability not only ensures compliance with FDA and USDA regulations but also integrates seamlessly into existing detection systems. By minimizing holding times and associated costs, as well as enabling quicker product releases, Pathotrak's technology aims to transform food safety practices and logistics in the industry, ultimately helping to prevent dangerous outbreaks and improve overall food safety.

Psyonic, Inc. specializes in developing advanced bionic limbs aimed at enhancing the lives of individuals with amputations. Founded in 2015 and headquartered in Champaign, Illinois, the company focuses on creating accessible, affordable solutions for its users. Its flagship product, an advanced bionic hand, is notable for its speed, ease of control, and ability to provide sensory feedback. The hand utilizes muscle pattern recognition and machine learning algorithms, allowing for customization based on the user's specific needs and preferences. Designed to withstand impacts, the bionic hand is intended to enable users to perform daily tasks with greater ease. Psyonic's goal is to ensure that the costs associated with its products are fully covered by insurance, minimizing out-of-pocket expenses for consumers.

PZA Innovation is a biotechnology company focused on developing a reliable testing method for pyrazinamide, a first-line drug used in tuberculosis treatment. The company employs reverse engineering techniques to determine the specific conditions under which pyrazinamide is effective in vitro, thereby enhancing its action against mycobacterium tuberculosis in a living host. By improving the understanding of pyrazinamide susceptibility, PZA Innovation aims to enable healthcare professionals to offer a next-generation treatment that could potentially shorten the duration of tuberculosis therapy for patients.

Lepidext is engaged in managing the populations of the Lepidoptera pests by introducing bio-pesticides that are species-specific. The company is committed to improving crop security and ensuring agricultural prosperity by combining a deep understanding of insect biology with the skills and experience of farmers. In 2015, Angelika Fath-Goodin and Bruce Webb established the company in Lexington, Kentucky.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, DNALite utilizes innovative oral lipid nanoparticle technology to deliver mRNA and pDNA directly to intestinal stem cells. This approach targets the underlying causes of diseases such as Familial Adenomatous Polyposis, a hereditary form of colorectal cancer that often necessitates invasive surgeries in adolescents. By enabling the intestinal tract to secrete therapeutic proteins into the bloodstream, DNALite aims to transform conventional protein biologics into oral medications, potentially improving patient outcomes and accessibility to treatment.

Bired Imaging specializes in infrared imaging technology aimed at enhancing breast cancer detection and localization, particularly in patients with dense breast tissue. Their medical imaging platform employs thermography and a proprietary computerized detection algorithm, which allows for the accurate identification of tumor size and location. This innovative approach enables healthcare professionals to detect high-risk patients at earlier stages, improving screening efficacy while also being cost-effective. Bired Imaging's solutions serve as an important adjunctive technology in breast cancer screening, contributing to more precise diagnostic processes.

Nanopath Inc. is a molecular diagnostics company focused on enhancing women's health through rapid and precise testing. By utilizing advancements in bioengineering and nanotechnology, the company specializes in the sensitive detection of viral, bacterial, and fungal pathogens without relying on nucleic acid amplification techniques. This innovative approach allows for the delivery of granular and clinically actionable information, thereby improving traditional testing methodologies and enabling healthcare providers to make informed decisions more swiftly.

Aqueduct Fluidics develops automation solutions for physical and life sciences research that fit on a laboratory benchtop. The company was founded in 2019 and is headquartered in Philadelphia, PA.

Atom Limbs is focused on advancing the field of prosthetics with its innovative mind-controlled artificial arms, specifically designed for under-elbow amputees and individuals with quadriplegia. The company’s flagship product, the Atom Touch, allows users to regain mobility by interpreting brain signals through implanted electrodes, facilitating natural and intuitive movement of the prosthetic limb. This technology is rooted in research and development conducted at the Johns Hopkins University Applied Physics Laboratory and has received substantial funding from DARPA. Atom Limbs aims to enhance the quality of life for those with mobility challenges by providing advanced, customizable solutions for artificial limbs.

Rubi Laboratories is a California-based company that specializes in the development of technology to manufacture carbon-negative textiles. The firm utilizes innovative sustainable solutions to convert carbon emissions into natural fibers, resulting in biodegradable textiles. Its technology directly synthesizes threads, providing a natural resource for the production of viscose that is carbon-negative, as well as being water-chemical, land-neutral, traceable, and environmentally friendly. Rubi Laboratories aims to address the environmental impact of textile manufacturing by offering a more sustainable alternative in the industry.

Astek Diagnostics is focused on developing a precision diagnostic platform that assists physicians in prescribing appropriate antibiotics for patients suffering from bacterial sepsis within one hour. The company’s technology utilizes a single-use cartridge to rapidly detect bacterial infections in urine by measuring the oxygen consumption of various bacterial species. This innovative approach not only speeds up the identification process but also aids in combating antibiotic resistance through effective susceptibility testing.

Vulcan Biologics is a biotechnology company based in Irvine, California, established in 2019. It specializes in the modulation of the microbiome through the use of bacteriophages, which are viruses that specifically infect bacteria without harming human cells. This innovative platform aims to achieve stable and persistent changes in the gut microbiome, facilitating the treatment of gluten-related disorders such as gluten sensitivity and celiac disease. By altering the composition of gut bacteria, Vulcan Biologics enables healthcare providers to offer targeted therapeutic solutions for individuals affected by these conditions.

CorInnova Incorporated provides device-based therapies for the treatment of congestive heart failure. CorInnova’s non-blood-contacting soft robotic cardiac assist device could potentially triple or quadruple the number of heart failure patients who could be eligible for such a life-saving device therapy.”

Zymosense specializes in the development of an enzyme screening platform that utilizes innovative technology to identify and characterize enzymes with specific properties. The company offers automated aqueous two-phase extraction for the efficient sorting of chiral-pure single-walled carbon nanotubes, enhancing the scalability and cost-effectiveness of this process. Additionally, Zymosense has demonstrated the potential for automating the NIST-developed ATP system for the separation of these nanotubes. Their tools, including a plate reader and a handheld reader, leverage fluorescent nanoparticles suspended in target enzyme substrates to produce activity probes, ensuring accuracy while maintaining user-friendliness. This combination of technologies enables research scientists and biotechnology companies to rapidly evaluate, discover, and design new enzymes, thereby advancing various applications across multiple industries.

Uncaged Innovations develops next-generation materials to recreate bovine and exotic leather through advancements in materials chemistry and digital manufacturing, providing businesses from luxury fashion to automotives with an alternative to animal skin and sustainable and ethical services.

InsectaPel provides biobased insect repellent products for textiles with regulatory compliance that will transform the market by providing cost-effective and highly functional sustainable repellent options.

Cision Vision is a developer and supplier of advanced imaging medical products focused on enhancing the examination of lymph nodes. Their innovative technology allows pathologists to visualize, scan, and record lymph nodes in real time with high contrast, without the need for injections or radiation. This capability supports the modernization of pathology practices, ensuring consistency and high-quality care in medical diagnostics. By providing these biotechnology tools, Cision Vision aims to improve the efficiency and accuracy of lymph node assessments in clinical settings.

Synvivia, Inc. is a biotechnology company founded in 2016 and based in Berkeley, California. It specializes in developing synthetic biology products, particularly ON-OFF switches for genetically engineered organisms. These protein switches can be controlled by small molecules, allowing for precise manipulation of biological functions. By integrating these switches into organisms, Synvivia aims to create engineered life forms that can be effectively used in healthcare. The company also focuses on generating biosensors that enhance enzymatic activities, facilitating easier disease diagnosis and enabling healthcare providers to deliver appropriate treatments.

Spekciton Biosciences provides biophotonic measurement systems and services, such as the rapid and precise early detection of plant stress and viability, as well as biosensors to detect fast soil and water contamination.

Organic Robotics Corporation, founded in 2018 and based in Rochester, New York, specializes in the design and development of advanced sensors that measure touch in real time. The company's flagship product, Light Lace, utilizes fiber-optic technology to create a flexible sensor capable of bending and twisting with the human body, offering effective motion capture and pressure sensing. This innovative solution combines sensibility, elasticity, and washability at a competitive cost. Additionally, Organic Robotics focuses on performance monitoring for professional athletes, providing real-time feedback on motion, muscle fatigue, and vital signs. Their technology is designed for comfort and minimal distraction, enabling accurate analysis of chest movement to deliver actionable insights regarding fatigue and performance levels.

BioSapien is a pre-clinical biotechnology company focused on creating innovative biodegradable implantable products for oncology applications. The company is developing a 3D-printed drug delivery platform that utilizes a biodegradable mesh to deliver active pharmaceutical ingredients (APIs) directly to tumor sites, thereby minimizing systemic side effects associated with traditional therapies. Their flagship product, the MediChip, is designed to administer FDA-approved high-dose systemic therapies in a localized and sustained manner, enhancing the quality of patient care. Current research is focused on applications for pancreatic and lung cancers, with plans to expand the pipeline to include other types such as colorectal, breast, and stomach cancers. By targeting drug delivery directly to cancerous tissues, BioSapien aims to improve treatment efficacy while reducing toxicity for patients.

Huue is a company focused on providing sustainable dyeing solutions for the denim and textile industries, specifically through the use of bio-synthesized indigo dyes. By employing fermentation biotechnology, the company utilizes naturally occurring microorganisms to produce colors, which significantly reduces the reliance on toxic chemicals traditionally used in dye production. This innovative approach not only enhances the environmental sustainability of the denim supply chain but also offers a greener alternative for fashion and textile manufacturers seeking to create eco-friendly products. Huue's commitment to harnessing renewable resources positions it as a leader in the movement towards more sustainable practices in the industry.

Aracari Biosciences specializes in developing advanced 3D Vascularized Micro-Organ platforms aimed at improving the drug discovery process. These platforms enhance the biological authenticity of pre-clinical testing by allowing for real-time imaging of vessel morphology, which facilitates the investigation of lead compound efficacy against tumors in a three-dimensional environment. The technology is designed to adapt to various physiological conditions and can be perfused with fluorophore-tagged dextrans of different molecular weights. This capability assists pharmaceutical companies in making informed decisions and accelerates the development of new drugs.

Envivo Bio develops a non-invasive device that collects microbiome samples from all regions of the human gastrointestinal tract. The company is based in San Carlos, California.

Felix Biotechnology is working to accelerate the deployment of novel biotherapeutics to manage infectious diseases. Felix Biotechnology's bio-therapeutics targets antibiotic-resistant bacteria to manage infectious diseases precisely and effectively, allowing healthcare professionals to manage urgent microbial challenges in human health.

AgroSpheres develops novel technologies that aim to set a new standard for bio-based delivery of active ingredients. It uses a unique platform technology for crop protection solutions and other industrial applications. The company is an encapsulation and delivery technology that dramatically enhances the performance of a broad range of crop protection products including fungicides, insecticides, and herbicides. AgroSpheres was founded in 2016 and is based in Charlottesville, Virginia.

Fortiphyte offers agricultural protection products that help to protect crops from disease and reduce fungicide use. The company was founded in 2017 and is based in Berkeley, California.

Biochip Labs provides blood disorder testing for conditions like sickle cell disease and thalassemia. The company was founded in 2019 and is headquartered in Cleveland, Ohio.

CollaMedix specializes in the development of collagen-based medical devices aimed at addressing soft tissue repair and augmentation. The company focuses on treating stress urinary incontinence in women, a condition that results in urine leakage during activities such as laughing, coughing, sneezing, lifting, and exercising. CollaMedix utilizes proprietary collagen materials to create a bio-inductive scaffold, which is a strong fabric designed to support human tissue and facilitate rapid cell integration. This innovative approach allows researchers to explore new and effective treatments for female pelvic health, ensuring safety and efficacy in their medical solutions.

Beta Analytic is a company specializing in radiocarbon dating and isotope analysis, serving various scientific fields including geochronology and environmental studies. The firm provides a range of services that encompass stable isotope analysis, biobased and natural product testing, essential oil testing, and renewable carbon measurement. Additionally, it offers nitrate source tracking and biofuels renewable carbon testing. By utilizing advanced techniques such as accelerator mass spectrometry and isotope ratio mass spectrometry, Beta Analytic enables researchers to accurately measure natural levels of radiocarbon and stable isotope ratios, facilitating the study of carbon-based materials for diverse applications.

SIEV Technologies develops a catalytic membrane technology that will convert biomass waste into useful bio-products. The company was founded in 2020 and is headquartered in Fayetteville, Arkansas.

xMD Diagnostics, based in Annapolis, Maryland, specializes in biotechnology within the healthcare sector. The company develops molecular diagnostics tools that use high-throughput microdissection technology to improve cancer diagnosis and management. These tools are designed to isolate, procure, and enrich cells of interest from biopsy and other specimen samples. This process facilitates various downstream analyses, including PCR, genomic or proteomic testing, and next-generation sequencing. By enhancing the capabilities of clinical and research laboratories, xMD Diagnostics supports pathologists, oncologists, and other healthcare professionals in diagnosing, monitoring, and treating patients with cancer and serious genetic diseases.

Sequegenics operates a fully automated cloud platform designed to detect structural variants and other complex types of genetic variations. By employing a novel approach that utilizes low-pass long-read next-generation sequencing (NGS), the platform processes raw DNA sequence data efficiently. This innovation allows clients to significantly reduce the time and costs associated with variant calling while enhancing scalability and turnaround times. Sequegenics aims to streamline the detection of complex genetic variations, thereby facilitating more effective genetic analysis for its users.

Niche Biomedical is a platform and therapy development firm that specializes in creating innovative solutions for chronic injuries and disorders that have not responded to traditional pharmacological treatments. The company has developed ANEUVO®, which focuses on addressing these challenging medical conditions. Among its notable innovations is ExaStim®, a non-invasive neuromodulation system that has received FDA Breakthrough Device Designation for the treatment of spinal cord injuries. Additionally, Niche Biomedical is advancing a gastrointestinal therapeutic device aimed at alleviating postoperative ileus and restoring gastrointestinal motility. This device leverages bioelectronic medicine to revolutionize treatment options for various diseases and injuries that are difficult to manage with conventional pharmaceuticals. The company is also capable of developing miniaturized implantable devices that maintain sophisticated functionality, allowing for targeted neuromodulation therapies.

Biko Biolabs is a research company focused on the intersection of plastic waste and regenerative agriculture. The company was founded in 2020 and is based in Somerville, Massachusetts.

Tethys Research focuses on discovering high-value enzymes and chemical entities by applying its expertise across various disciplines to address challenges unsuitable for high-throughput screening methods. The company operates as a discovery entity, creating innovative technologies and collaborating with organizations that manufacture and market chemical products and processes. Through its contract and partnership initiatives, Tethys Research aims to enhance the capabilities of businesses in the chemical industry by providing tailored solutions that meet specific needs.

TheraCea Pharma is a biotechnology company based in Tucson that focuses on developing precision medicine for individuals with neurological disorders. As a spin-off from the University of Arizona, the company has developed and licensed advanced radiochemistry technology that enables efficient and rapid fluorine-18 radiolabeling of biomolecules. This innovative approach supports both clinical and research applications, particularly in the context of neurological conditions. TheraCea Pharma's treatments aim to counteract dyskinesia, a side effect commonly associated with L-dopa, the standard treatment for Parkinson's disease. By providing new diagnostic agents, the company enhances medical professionals' capabilities in detecting not only neurological disorders but also cancer, thereby contributing to improved healthcare outcomes.

TRGel, founded in 2010 and located in Irvine, California, specializes in the development of glucose-based biopolymers designed to serve as an alternative to calcium alginate for encapsulation purposes. The company’s biopolymers are crafted from biocompatible materials, which encompass thermoresponsive hydrogels with adjustable gelation temperatures. These innovative biopolymers enable researchers to utilize them effectively as vehicles for drug delivery, expanding the possibilities for applications in various fields.

NanoSpy, Inc., founded in 2017, specializes in rapid pathogen detection through advanced biosensor technology. The company has developed proprietary and patent-pending biosensors that enable the detection of targeted pathogens with high sensitivity and specificity. These biosensors can identify live bacteria at concentrations as low as 5 CFU/mL within just 20 minutes, eliminating the need for time-consuming enrichment processes, hazardous reagents, or laboratory settings. By utilizing standard sampling methods and low-cost supplies, NanoSpy's technology allows for quick and accurate results, thereby enhancing safety testing for researchers and streamlining the detection process. This innovative approach represents a significant advancement in the field of pathogen detection.

Kodikaz goal is to move from incremental cancer therapies with devastating side effects to durable cures through targeted therapies that can eradicate cancers. Zip-Code™ Technology platform is a first-in-class, cell-specific delivery system that can be used for a broad range of gene therapy applications. Because the Zip-Codes ™ is derived from an endogenous human mechanism it avoids all of the challenges of viral delivery approaches. The Zip-Codes ™ are universally applicable and specific for each cell type.

ZelosDx specializes in the development of blood testing products aimed at advancing research in brain health and diseases. The company provides researchers with access to proprietary technology that can be licensed and adapted for blood testing kits and automated laboratory equipment. Additionally, it offers pharmaceutical collaborators biomarker technology to support drug discovery efforts. By delivering critical data for diagnosis, monitoring, and evaluating therapeutic responses, ZelosDx facilitates significant advancements in the understanding and treatment of brain-related conditions.

Nano PharmaSolutions specializes in enhancing the bioavailability of insoluble drugs through its proprietary nanoformulation technology. The company has developed an innovative phase-transition technology platform that significantly improves the solubility of BCS 2 and BCS 4 active pharmaceutical ingredients (APIs) without the need for excipients, which are typically used in traditional processes like spray-dry dispersion and emulsification. By vaporizing the API and depositing it onto a carrier molecule, Nano PharmaSolutions enables the production of nanoparticles that can be processed into various dosage forms. Additionally, the company focuses on delivering neurodegenerative therapeutics directly to the brain via an intranasal route, facilitating a rapid onset of action and enhancing safety profiles. Their pipeline includes treatments for conditions such as Parkinson's disease, peripheral neuropathy, and substance abuse disorders, positioning Nano PharmaSolutions as a key player in the field of nanomedicine.

Ancilia Biosciences focuses on developing engineered bacterial therapies aimed at treating diseases associated with the microbiome. The company specializes in creating virus-resistant live bacterial products that modulate the human microbiome, specifically targeting the viral components within the gut microbiome. By concentrating on healthy gut bacteria and their predatory phages, Ancilia engineers resistant bacterial strains to combat diseases. Its innovative approach includes the development of a new class of live biotherapeutics that allows medical professionals to target specific phages or viruses that induce lysis, with applications in immunology and oncology.

MedChem Partners is a medicinal chemistry CRO that specializes in developing small molecule therapeutics. The company was founded in 2006 and is headquartered in Lexington, Massachusetts.

BioSens8 is a developer of advanced biosensors designed to enhance health monitoring and prevent chronic diseases. The company's innovative platform offers real-time, quantitative biosensors that serve various applications. In healthcare, these biosensors assist women in assessing their fertility health, providing crucial information for family planning. In agriculture, BioSens8's technology enables farmers to manage herds effectively and optimize animal reproduction. Additionally, the biosensors can evaluate environmental health, contributing to the revitalization of fragile ecosystems. By catering to the healthcare, agriculture, military, and biomanufacturing sectors, BioSens8 aims to provide efficient solutions for holistic health monitoring.

Theromics Inc. is a biotechnology company focused on developing innovative cell therapies, particularly in the field of thermal ablation for cancer treatment. Founded in 2016 and based in West Bridgewater, Massachusetts, the company has created HeatSYNC Gel, a biopolymer thermal accelerant designed to enhance the effectiveness of microwave and radiofrequency ablation procedures. This gel improves the delivery and absorption of thermal energy in soft tissue and bone, optimizing the ablation zone's shape and volume. By increasing local tissue electrical conductivity, HeatSYNC Gel helps to prevent heat loss due to blood flow, allowing for more precise targeting of tumors and protecting surrounding healthy tissue. The gel can be administered through various methods, including syringe, laparoscope, and bronchoscope, and is intended to improve the overall efficacy of thermal ablation therapies while enabling personalized treatment approaches.

Sequitur Health, founded in 2019 and based in Scottsdale, Arizona, specializes in the development of innovative medical devices aimed at enhancing patient care and improving quality of life. The company focuses on addressing unmet needs of patients and physicians by leveraging technological advancements. By collaborating with educational and medical institutions in Arizona, Sequitur Health creates solutions that enable healthcare providers to deliver timely and effective care to patients.

Inherent Targeting develops fluorescent contrast agents that target nerves to improve surgical outcomes. The company was founded in 2019 and is headquartered in Portland, Oregon.

Tender Food is a food technology startup focused on developing plant-based and cultured meat products. Founded by researchers from Harvard University, the company utilizes novel fiber production technology to transform plant proteins into fibrous structures that closely replicate the texture and mouthfeel of traditional meat. This innovative method aims to create alternative meats that not only match the taste and nutritional value of animal meat but also promote vegan food options. Through its sustainable approach, Tender Food seeks to support meat companies and enhance the consumer experience with realistic and environmentally friendly alternatives.

SingletO2 Therapeutics creates new treatments for periodontal disease using singlet oxygen. The company was founded in 2015 and is headquartered in New Providence, New Jersey.

Frugi Biotechnology is a synthetic biology company that creates modular, paper-based, secure diagnostics for viral outbreak management. The company was founded in 2020 and is headquartered in Ames, Iowa.

Drive Therapeutics is a new biotechnology company that strives to improve treatment for retinal diseases.

NeuroTechR3 is a biomedical device and digital health start-up that focuses on developing affordable rehabilitation technologies to enhance upper extremity function for individuals affected by brain injuries, including stroke and cerebral palsy. The company's flagship innovation, R3THATM, leverages machine learning and cloud technology to enable personalized telerehabilitation through engaging exergames designed to foster neuroplasticity. This system includes features such as motion tracking, analytics, and real-time biofeedback, which help clinicians provide high-quality, efficient care while improving patient recovery outcomes. Founded in 2020 by a team of four women, NeuroTechR3 emerged from the New Jersey Institute of Technology and Rutgers University, and operates from locations in Newark, NJ, and Philadelphia, PA. The company's expertise lies in biomedical engineering and computer science, positioning it to address the needs of the rehabilitation industry effectively. By advancing rehabilitation devices and machine learning-driven technologies, NeuroTechR3 aims to transform healthcare and make rehabilitation more accessible and sustainable for individuals with various impairments.

Paramita Therapeutics is a biotech company established in 2018 and based in San Diego, California. The company is dedicated to developing innovative therapeutics for cancer and infectious diseases. It specializes in efficiently transitioning new therapeutics into clinical settings using a patented, multifunctional chemical platform. This approach allows Paramita Therapeutics to create multivalent drug conjugates derived from recognized and approved molecules with established safety and toxicology profiles. By leveraging its expertise, the company aims to provide patients with access to effective cancer treatments and dual-function therapeutic and vaccine products.

InSoma Bio integrates biology and materials science to solve problems in tissue engineering and regenerative medicine. It offers genetically engineer protein-based materials that can mimic the naturally found elastin found in extracellular tissues. The company also offers reconstructive plastic surgeries and injectable materials.

Avior Bio is a clinical-stage, pharmaceutical company developing drugs for distressed neurological conditions. Using its disruptive drug delivery technology – Speedit™ Transmucosal Film Technology – we are positioned to develop products that bring unsurpassed value in efficacy and safety. Avior has an excellent management team, a strong advisory board, supportive partners, dedicated scientists, and knowledgeable clinicians that position us to be successful.

Tacit Therapeutics created RNA-targeting treatments for devastating diseases. By repurposing pre-existing components of human cells, we have created the first broadly applicable and inherently non-immunogenic means to repair mutated genes. The company was founded in 2021 and is based in South San Francisco, California.

Verantos is the market leader in high-validity real-world evidence for life sciences. By incorporating robust clinical narrative data, artificial intelligence technology, and measured validity, Verantos is the first company to generate research-grade evidence at scale across all therapeutic areas. The Verantos Evidence Platform integrates heterogeneous real-world data sources and generates evidence with the accuracy necessary for market access, HEOR, medical affairs, and regulatory use.

Partillion Bioscience is an early-stage life science company focused on developing a functional single-cell analysis platform. This innovative platform utilizes a novel nano vial technology to rapidly compartmentalize and analyze millions of single cells, specifically targeting secreted proteins. By enabling detailed examination of biological functions, Partillion aims to democratize advanced single-cell assays for biotech laboratories and clients. This capability supports the development of more effective therapies for various conditions, including cancer, autoimmune diseases, and infectious diseases.

Vectech is a public benefit corporation based in Baltimore, MD, specializing in an AI-based diagnostic system for medical entomology. The company has developed an identification system that accurately determines species, sex, and other essential characteristics of mosquito and tick populations. This technology is currently deployed in seven countries and serves various clients, including municipal and national public health programs, NGOs, and malaria control initiatives. By providing tools that reduce labor costs associated with mosquito surveillance, Vectech empowers researchers and public health organizations to detect threats from mosquito-borne diseases like dengue and malaria, facilitating early intervention and customized responses to potential outbreaks.

Gate Scientific makes products that enable great research and improve healthcare decisions by bringing to market intuitive solutions that simplify complex problems. By bringing to market intuitive solutions that simplify complex problems, they allow for the latest technologies to benefit more people.

Ostiio is focused on developing an innovative bone distraction system aimed at correcting skeletal deformities and deficiencies. The company has created a fully implantable device that is buried beneath the patient's skin, eliminating the need for external components. This advanced system features a magnetically driven distraction mechanism that can be expanded with precision and monitored remotely by physicians. This programmability provides surgeons with enhanced transparency and control during the treatment process, addressing a longstanding challenge in skeletal correction. Ostiio operates as a company under the Penn Center for Innovation, emphasizing its commitment to advancing medical technology in orthopedics.