National Institutes of Health

Caretaker Medical, LLC is a developer and manufacturer of wireless patient monitoring devices, based in Charlottesville, Virginia, with additional locations in Surrey, United Kingdom, and Beijing, China. The company offers an innovative wearable monitoring system that utilizes a simple finger cuff to continuously measure vital signs such as blood pressure, heart rate, respiration rate, and other hemodynamic parameters. This device allows clinicians to securely transmit data over cellular networks or Bluetooth, enabling real-time monitoring and improving patient outcomes across the continuum of care—within hospitals, during transport, and after discharge. The system is designed to enhance mobility, simplicity, and cost-effectiveness while ensuring compliance with health regulations. By providing accurate, ICU-level monitoring in a non-invasive format, Caretaker Medical aims to improve patient comfort and facilitate better healthcare delivery.

CardieX Limited is a global health technology company specializing in cardiovascular health management. Founded in 1994 and headquartered in Sydney, Australia, the company designs, manufactures, and markets medical devices aimed at measuring patient risk for hypertension, cardiovascular disease, and other vascular disorders. Its product offerings include devices that utilize patented SphygmoCor technology to assess arterial stiffness and central blood pressure waveforms. Additionally, CardieX develops the Arty platform, which provides physiological and health analytics for wearable devices. The company also offers TeleHealth Services, connecting patients with health coaches through digital and mobile tools. CardieX's solutions are provided to hospitals, clinics, research institutions, and pharmaceutical companies globally. The company has strategic partnerships, including a collaboration with Blumio Inc. for developing wearable sensors and a joint development agreement with inHealth for hypertension and cardiovascular programs. CardieX was previously known as AtCor Medical Holdings Limited until its name change in June 2018.

Amissa develops mobile and wearable application solutions aimed at alleviating the challenges of Alzheimer's care. The company’s technology empowers caregivers by allowing them to geo-fence and locate loved ones who may wander, remotely monitor their activity and health, and predict behaviors associated with Alzheimer's. In addition to these features, Amissa offers wearable biosensors integrated with a cloud-based data platform that collects biometric data on activity levels, sleep patterns, and physiological changes. This comprehensive approach not only aids caregivers in monitoring patients but also provides valuable insights for researchers seeking to understand disease progression, ultimately enhancing the quality of life for individuals with dementia and related disorders.

Lasarrus is a medical device company founded in 2013 and headquartered in Baltimore, Maryland. The company specializes in developing wearable devices aimed at enhancing the physical therapy experience for patients, particularly those with chronic obstructive pulmonary disease. Lasarrus's innovative device facilitates remote monitoring and telemedicine by capturing physiological and range-of-motion data from various points on the body. This technology provides patients with an affordable, comfortable, and non-invasive means to track their health routines and accelerate their recovery process.

Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior integrates wearable devices with machine learning algorithms to analyze real-time data from various physiological metrics, such as heart rate and skin temperature. The company’s platform, known as Recovery, employs this data to deliver timely interventions tailored to the needs of individuals in recovery. By utilizing a SaaS business model, Behaivior aims to democratize mental health recovery and support, assisting users in maintaining their wellness while enabling care providers to enhance their service delivery. Through its proactive approach, Behaivior seeks to improve mental health outcomes and reduce crisis events associated with addiction.

Rhaeos is a pioneering company that has developed the world's first wearable shunt monitor, designed to enhance the quality of care for patients with hydrocephalus. Utilizing a novel thermal biosensor, Rhaeos addresses a critical clinical need by offering noninvasive, wireless patches that detect fluid flow in various bodily systems, including blood, lymph, and cerebrospinal fluid. This innovative technology enables timely treatment for chronic medical conditions, particularly in the field of neurosurgery. Founded through collaborative efforts at Northwestern University, Rhaeos exemplifies a multidisciplinary approach, integrating expertise from engineering, medicine, and management to advance patient care.

NeuroGeneces is a company that leverages advanced neuroscience, sleep expertise, and artificial intelligence to enhance cognitive healthspan through comprehensive brain health assessments. The company has developed a sleep performance device that utilizes machine learning algorithms to analyze patient EEG data, comparing it with a proprietary normative database to determine biological brain age. This innovative approach allows healthcare practitioners to objectively evaluate brain function and develop targeted intervention strategies. Additionally, the device monitors sleep quantity and quality, measures changes in heart rate variability, and aims to identify signs of neurodegeneration well before cognitive symptoms appear, enabling timely and effective interventions. By focusing on wellness and preventative care, NeuroGeneces aims to support users in optimizing their mental and physical performance.

Sensor-Kinesis Corporation develops innovative medical devices focused on pathogen and virus detection. Founded in 2013 and based in Los Angeles, the company is advancing proprietary biosensor technology that integrates flexible micro biosensor chips with computer systems. These chips are designed to detect specific biomolecules and can be printed on various surfaces, enabling widespread application across multiple industries, including healthcare, food safety, and pharmaceuticals. By linking these sensors to smart devices, users can transmit and analyze biological signals in real time, facilitating improved health monitoring. Sensor-Kinesis aims to empower healthcare professionals and individuals with affordable, portable devices that provide enhanced detection capabilities for diseases and health-related risks, promoting better health outcomes and safety.

CardieX Limited is a global health technology company specializing in cardiovascular health management. Founded in 1994 and headquartered in Sydney, Australia, the company designs, manufactures, and markets medical devices aimed at measuring patient risk for hypertension, cardiovascular disease, and other vascular disorders. Its product offerings include devices that utilize patented SphygmoCor technology to assess arterial stiffness and central blood pressure waveforms. Additionally, CardieX develops the Arty platform, which provides physiological and health analytics for wearable devices. The company also offers TeleHealth Services, connecting patients with health coaches through digital and mobile tools. CardieX's solutions are provided to hospitals, clinics, research institutions, and pharmaceutical companies globally. The company has strategic partnerships, including a collaboration with Blumio Inc. for developing wearable sensors and a joint development agreement with inHealth for hypertension and cardiovascular programs. CardieX was previously known as AtCor Medical Holdings Limited until its name change in June 2018.

Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior integrates wearable devices with machine learning algorithms to analyze real-time data from various physiological metrics, such as heart rate and skin temperature. The company’s platform, known as Recovery, employs this data to deliver timely interventions tailored to the needs of individuals in recovery. By utilizing a SaaS business model, Behaivior aims to democratize mental health recovery and support, assisting users in maintaining their wellness while enabling care providers to enhance their service delivery. Through its proactive approach, Behaivior seeks to improve mental health outcomes and reduce crisis events associated with addiction.

Epicore Biosystems, Inc. is a Cambridge, Massachusetts-based company that develops and commercializes a proprietary wearable microfluidic sensing platform designed for athletes. Founded in 2017, the company focuses on analyzing small droplets of sweat directly from the skin to measure a range of health and performance metrics. Its technology allows for non-invasive monitoring of sweat biomarkers, skin health, and physiological states in real-time, facilitating personalized management of hydration, nutrition, and overall health. Epicore's innovative platform is grounded in extensive research in microfluidics and soft materials, aiming to enhance athletic performance and health management through accessible and cost-effective solutions.

Xtrava Health, established in 2014 and headquartered in Santa Clara, California, specializes in developing contactless bio-sensing technology for health and wellness applications. The company's flagship product, Butterfly, is a wearable child wellness monitor that automatically tracks vital signs, sleep patterns, feeding, diaper changes, and activities, providing parents with comprehensive insights. Xtrava Health also develops and commercializes simple, accurate, and affordable diagnostic products for both professional and at-home use, focusing on respiratory health, employee wellness, and baby monitoring.

Biomotum is a company that specializes in the design and development of wearable robotic exoskeletons aimed at enhancing mobility for individuals facing challenges in walking due to health issues. The company's innovative systems integrate advanced assistive technology with user-friendly therapeutic features, providing real-time training insights and compatibility with tele-rehabilitation. Biomotum's products are particularly beneficial for those affected by neurologic disorders such as stroke and cerebral palsy, offering embedded progress reporting to facilitate effective rehabilitation. Through its focus on empowering mobility, Biomotum addresses the growing need for solutions that support individuals with mobility impairments.

Arcascope is a technology company that specializes in developing health and fitness applications. Their primary focus is on creating apps that utilize algorithms to track users' circadian rhythms. By analyzing data from phones and wearable devices, Arcascope accurately monitors the body's internal clock. This information is used to generate personalized recommendations aimed at helping individuals manage their fatigue and improve their overall well-being by aligning with their natural sleep-wake cycles.

Samay is a developer of an innovative AI-enabled wearable device focused on remote respiratory health management. The company addresses the growing need for effective chronic obstructive pulmonary disease (COPD) diagnostics and management, projected to incur significant healthcare costs in the coming years. Their patented chest patches provide passive monitoring of lung function, achieving 90% accuracy in COPD diagnosis and 83% accuracy in detecting exacerbation biomarkers. The device continuously tracks vital respiratory metrics, including pulmonary volumes, heart rates, and breathing sounds for two weeks, offering users valuable insights to optimize their respiratory health. Additionally, Samay is creating an AI-assisted management platform that supports patients and healthcare providers throughout the care continuum, enhancing personalized care from the comfort of home.

AventuSoft specializes in developing innovative biologically inspired solutions aimed at enhancing human efficiency and functionality through advanced engineering. The company focuses on creating cloud-connected wearables designed for cardiopulmonary assessment, particularly in pre-clinical heart failure diagnosis. By utilizing in-depth knowledge of psychoacoustics and novel signal processing techniques, AventuSoft's products aim to simplify medical diagnostics, making cardiac monitoring more accessible and efficient compared to traditional methods. Additionally, the company develops sensors and controls that employ computational auditory scene analysis, which helps in separating and locating sounds in complex auditory environments. This technology not only aids in improving audio-visual aids for hearing-impaired individuals but also democratizes access to high-quality diagnostics, offering significant benefits to patients.

Intake Health is a company focused on continuous passive health monitoring through innovative technology. Its primary product is a device that hangs on a toilet, automatically testing urine from flush water to provide lab-quality results for various health and diet indicators. This device does not require any behavior changes from users, making it easy to integrate into daily life. By utilizing advanced biosensors and wireless technology, the device quantifies specific urinary biomarkers to accurately track hydration and nutrition, delivering instant insights directly to users' smartphones. The company believes that leveraging artificial intelligence alongside thousands of personalized biomarkers collected over time will enhance the prediction of health conditions and support personalized preventive care as its user base expands. Intake Health has received funding from notable organizations such as the National Science Foundation and the National Institutes of Health.

Recovery Force, founded in 2013 and headquartered in Fishers, Indiana, is a company specializing in the development and manufacture of wearable medical technology designed to enhance mobility and circulation. The company's flagship product, MORPH, utilizes S.M.A.R.T. technology incorporating nitinol with a proprietary algorithm to deliver rhythmic, sequential compression that increases blood flow to targeted muscles and tissues. This innovative approach aims to reduce post-operative pain, swelling, and wound healing time, treat chronic conditions like lymphedema, prevent blood clots, and alleviate joint pain and sore muscles. Recovery Force's solutions are designed for use by healthcare professionals, patients, and athletes, addressing the evolving needs of healthcare from hospital to home.

Skelmet Inc. is a Boston-based company that specializes in the design and production of custom head-worn products, including sunglasses, lenses, and accessories for various sports such as running, cycling, skiing, and fishing. Founded in 2015, Skelmet leverages advanced 3D Fit technology, which integrates 3D scanning and printing to create bespoke products that ensure a perfect fit for individual users. Among its notable offerings is the Falcon I, recognized as the world’s first true custom-fit sport sunglasses, which are lightweight and engineered for superior performance. In addition to its physical store, Skelmet sells its products online and provides a mobile application that allows users to scan their heads and faces, facilitating the quick and easy creation of personalized wearables.

Arcascope is a technology company that specializes in developing health and fitness applications. Their primary focus is on creating apps that utilize algorithms to track users' circadian rhythms. By analyzing data from phones and wearable devices, Arcascope accurately monitors the body's internal clock. This information is used to generate personalized recommendations aimed at helping individuals manage their fatigue and improve their overall well-being by aligning with their natural sleep-wake cycles.

Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior integrates wearable devices with machine learning algorithms to analyze real-time data from various physiological metrics, such as heart rate and skin temperature. The company’s platform, known as Recovery, employs this data to deliver timely interventions tailored to the needs of individuals in recovery. By utilizing a SaaS business model, Behaivior aims to democratize mental health recovery and support, assisting users in maintaining their wellness while enabling care providers to enhance their service delivery. Through its proactive approach, Behaivior seeks to improve mental health outcomes and reduce crisis events associated with addiction.

Modulim is a pioneering company specializing in advanced tissue and vascular assessment technology through its innovative Clarifi Imaging System. Utilizing spatial frequency domain imaging (SFDI), Modulim's devices facilitate the identification of patients at risk for complications such as diabetic foot ulcers and amputations, thereby enabling clinicians to intervene promptly and potentially save lives. The company develops light-based imaging devices that cater to various fields, including research, aesthetics, and medicine. By leveraging a unique photography capture-and-analysis method, Modulim provides healthcare professionals with transformative tools that enhance the prevention, diagnosis, and treatment of medical skin conditions.

Wearable sensors are transforming healthcare by empowering health researchers, care providers, and patients with new insights.Together with their clinical research and enterprise partners, They develop innovative, market driven, wearable sensor solutions that address some of healthcare’s biggest challenges.

Mobile Sense Technologies, Inc. specializes in the development of innovative wearable wireless sensor bands for cardiac monitoring. Its primary product, SensBand, is designed to be worn on the arm or wrist and enables automatic monitoring, detection, and reporting of dangerous heart arrhythmias directly to patients and their healthcare providers. Founded in 2016 and based in Farmington, Connecticut, the company has invested significant resources into creating a platform for differentiated wearables. The technology includes non-adhesive, wireless, and waterproof sensors that provide continuous ECG and PPG recordings, allowing for 24/7 monitoring and classification of heart conditions. Mobile Sense Technologies aims to transform the traditional diagnostic market by utilizing advanced wearables that facilitate long-term management of cardiac health.

ReThink Medical, Inc. is a medical device and digital health company based in San Francisco, California, founded in 2010. The company specializes in the development of wrist-worn monitoring devices designed to predict and prevent hospitalizations due to heart failure. Their flagship product, CorBand™, utilizes advanced algorithms and artificial intelligence to continuously monitor physiological indicators such as heart rate and fluid status. This technology enables early detection of worsening heart conditions, potentially weeks in advance of noticeable symptoms. By focusing on compliance and ease of use, ReThink Medical aims to provide proactive management of heart failure patients, improving their quality of life while reducing healthcare costs associated with emergency interventions. In 2020, ReThink Medical became a subsidiary of Terumo Corporation.

Epitel is a digital health company focused on developing a wearable, wireless EEG monitoring platform aimed at enhancing seizure detection. The company's innovative device utilizes a proprietary cloud-based sensor system combined with advanced artificial intelligence technologies to accurately identify abnormal brain activities. By prioritizing accessibility, affordability, and reliability, Epitel enables physicians, caregivers, and patients with neurological disorders to obtain critical brain health insights, ultimately improving their quality of life and care.

SpeechVive Inc. is a medical technology company based in Lafayette, Indiana, that focuses on developing innovative communication solutions for individuals with Parkinson's disease. Founded in 2011, the company specializes in the design and manufacture of a wearable speech device aimed at enhancing the speech capabilities of patients. This device effectively reduces background noise, thereby improving the user's ability to hear and facilitating increased speech volume and clarity. By addressing the communication challenges faced by those with Parkinson's disease, SpeechVive aims to help patients lead more normal and fulfilling lives.

Shade is a New York-based company that specializes in the design and development of wearable ultraviolet measuring technology. Its primary focus is on creating ultra-accurate and ultra-sensitive UV sensors, specifically aimed at assisting patients with lupus, skin cancer, and diabetes. The company's innovative devices provide real-time and precise measurements of UV exposure, based on clinical evidence. By determining daily UV exposure thresholds, Shade's sensors enable patients to receive timely notifications, helping them make informed decisions about sun exposure. This technology is particularly beneficial in the field of dermatology for managing photosensitive diseases and enhancing patient care.

Chrono Therapeutics Inc. is a pharmaceutical company based in Hayward, California, focused on revolutionizing drug delivery and addiction management. Founded in 2003, the company specializes in the development of SmartStop, a digital nicotine replacement therapy that employs a wearable device to deliver programmable, transdermal drug therapy. This innovative system is designed to tailor the timing and dosage of nicotine while providing real-time behavioral support to help users manage addiction and smoking cessation effectively. Chrono Therapeutics aims to address the challenges associated with smoking addiction through its advanced technology, which seeks to achieve optimal clinical outcomes and improve the overall quality of life for users. The company's leadership team brings extensive experience in product development, research and development, and navigating regulatory pathways, positioning Chrono Therapeutics as a key player in the smoking cessation market.

UroDev Medical is a company focused on developing innovative medical devices aimed at enhancing the quality of life for individuals with spinal cord injuries and diseases. Its flagship product, The Connected Catheter, introduces a semi-permanent, minimally-invasive smart catheter system. This device measures bladder pressure and wirelessly transmits data to a smartphone, streamlining bladder management for users. By eliminating the need for intermittent catheters and drainage bags, UroDev Medical enables both users and clinicians to effectively control the valve that facilitates urine drainage from the bladder.

Epitel is a digital health company focused on developing a wearable, wireless EEG monitoring platform aimed at enhancing seizure detection. The company's innovative device utilizes a proprietary cloud-based sensor system combined with advanced artificial intelligence technologies to accurately identify abnormal brain activities. By prioritizing accessibility, affordability, and reliability, Epitel enables physicians, caregivers, and patients with neurological disorders to obtain critical brain health insights, ultimately improving their quality of life and care.

ReThink Medical, Inc. is a medical device and digital health company based in San Francisco, California, founded in 2010. The company specializes in the development of wrist-worn monitoring devices designed to predict and prevent hospitalizations due to heart failure. Their flagship product, CorBand™, utilizes advanced algorithms and artificial intelligence to continuously monitor physiological indicators such as heart rate and fluid status. This technology enables early detection of worsening heart conditions, potentially weeks in advance of noticeable symptoms. By focusing on compliance and ease of use, ReThink Medical aims to provide proactive management of heart failure patients, improving their quality of life while reducing healthcare costs associated with emergency interventions. In 2020, ReThink Medical became a subsidiary of Terumo Corporation.

Xhale is a company based in Gainesville, Florida, founded in 2005, that specializes in developing advanced patient monitoring technologies. The company is known for its innovative SMART medication adherence monitoring technology and a propofol monitor, both aimed at enhancing patient care in clinical settings. Xhale's devices are designed to improve conventional pulse oximetry by enabling the monitoring of critical patient parameters through a simple, effective single-point-of-contact sensor. In 2010, Xhale successfully commercialized its HyGreen hand hygiene monitoring system, which later became a separate entity with its own management team. The company's focus on expanding the capabilities of patient monitoring is intended to improve health outcomes in hospitals and other clinical environments.