National Institutes of Health

The National Institutes of Health (NIH) is a leading biomedical research facility in the United States, operating under the Department of Health and Human Services. Established in 1887 and based in Bethesda, Maryland, NIH is the primary agency responsible for biomedical and health-related research in the country. It comprises 27 separate institutes and centers, each focusing on different disciplines within biomedical science. NIH conducts its own scientific research through the Intramural Research Program and provides significant funding for research at external institutions via the Extramural Research Program. With a workforce that includes 1,200 principal investigators and over 4,000 postdoctoral fellows, NIH has been instrumental in major medical breakthroughs, such as the development of vaccines for hepatitis and human papillomavirus, as well as the discovery of treatments for various health conditions. As the world's largest source of medical research funding, NIH continues to advance scientific knowledge and contribute to public health improvements.

Francis Collins

Director

Nick Langhals

Supervisory Program Director

Past deals in Wearables

Rhaeos

Grant in 2023
Rhaeos is a pioneering company that has developed the first wearable shunt monitor to enhance care for patients with hydrocephalus. Utilizing a novel thermal biosensor, the device allows for noninvasive, real-time monitoring of cerebrospinal fluid flow. This innovative technology, born from collaborative research at Northwestern University involving experts from engineering, medicine, and management, addresses a significant clinical need by providing timely data to improve treatment for chronic medical conditions. Rhaeos's patches are designed to detect fluid flow in various bodily systems, including blood and lymph, facilitating quicker medical responses and advancing the standard of care in neurosurgery and beyond.

NeuroGeneces

Grant in 2023
NeuroGeneces utilizes advanced neuroscience, sleep expertise, and artificial intelligence to deliver brain health assessments aimed at enhancing cognitive longevity. The company has received funding from various reputable sources, including government agencies and private investors. Its flagship product is a sleep headband equipped with machine learning algorithms that analyze EEG data, comparing it against a proprietary normative database to determine an individual's biological brain age. This innovative approach allows healthcare practitioners to objectively evaluate brain function and develop targeted intervention strategies. Additionally, the device monitors sleep patterns, including quantity, quality, and heart rate variability, providing essential support for clinicians focused on wellness and preventative care. By identifying neurodegeneration early, NeuroGeneces aims to empower users to optimize their mental and physical performance.

Behaivior

Grant in 2023
Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior develops a platform that combines wearable devices and machine learning algorithms to monitor key physiological signals such as heart rate and motion. This system, known as Recovery, is designed to support mental health recovery and wellness by delivering timely interventions based on real-time data. By utilizing a software-as-a-service (SaaS) model, Behaivior empowers individuals to maintain their recovery process while enabling care providers to better assist their clients. The integration of AI and behavioral health technology allows Behaivior to recognize patterns in human behavior, ultimately aiming to enhance mental well-being and reduce the incidence of crises, including relapse.

Epicore Biosystems

Series A in 2022
Epicore Biosystems, Inc. is a Cambridge, Massachusetts-based company founded in 2017 that specializes in developing and commercializing a wearable microfluidic sensing platform. This innovative technology analyzes small droplets of sweat directly from the skin to provide insights into health, hydration, and athletic performance. The platform is designed to measure various biomarkers, including proteomics and inflammatory markers, allowing for personalized management of health and nutrition. Epicore's approach leverages over two decades of research in microfluidics and soft materials conducted by leading experts at Northwestern University. By offering a non-invasive and cost-effective solution, Epicore aims to enhance athletic performance and improve overall health monitoring for users.

Biomotum

Grant in 2020
Biomotum specializes in the design and manufacturing of wearable robotic exoskeletons aimed at improving mobility for individuals facing challenges in walking. The company addresses the growing health issues related to mobility impairments, particularly for those affected by neurological disorders such as stroke and cerebral palsy. Biomotum's innovative systems integrate advanced assistive technology, offering a user-friendly therapeutic solution that features real-time training insights, compatibility with tele-rehabilitation, and built-in progress reporting. This approach enhances the rehabilitation process for users, empowering them to regain mobility and improve their quality of life.

AventuSoft

Grant in 2020
AventuSoft is a pioneer in biologically inspired solutions! Our mission, is to continuously enhance the efficiency and function of people through advanced biologically inspired engineering. The human auditory system is an existence proof for accurate speech processing and has solved the principal complexities that currently plague speech processing solutions: multiple sources, noisy environments, and mismatched test/train data. Solutions by AventuSoft, are developed by applying in-depth knowledge of psychoacoustics, biological signals, and novel signal processing techniques to leverage the benefits seen in human system.

Intake Health

Grant in 2019
Intake Health is a developer of a continuous passive health monitoring device that operates at home without requiring changes in user behavior. The device is designed to be mounted on a toilet, where it automatically tests urine from flush water to deliver lab-quality results for various health and dietary indicators. By leveraging advanced biosensors and wireless technology, the system accurately tracks hydration and nutrition by quantifying specific urinary biomarkers. Users receive instant insights on their health metrics through a mobile application, facilitating informed decision-making regarding their well-being. Intake Health aims to enhance health predictions and personalized prevention strategies through the accumulation of personalized biomarkers over time. The company has received funding from the National Science Foundation and the National Institutes of Health.

Recovery Force

Grant in 2019
Recovery Force Health, LLC, based in Fishers, Indiana, specializes in the development and manufacturing of innovative health care apparel and wearable medical technology. Founded in 2013 by Matthew Wyatt, the company emerged from a personal experience where Wyatt sought to improve patient care following surgical procedures. Recovery Force offers a range of products, including sleeves and shoes, designed for healthcare professionals, patients, and athletes. Central to their offerings is the MORPH system, which utilizes S.M.A.R.T. technology and nitinol to provide rhythmic, sequential compression that enhances blood flow to targeted areas of the body. Their non-pneumatic platform aims to reduce post-operative pain and swelling, expedite wound healing, treat chronic lymphedema, and alleviate joint pain and muscle soreness. Recovery Force is committed to integrating data-driven solutions throughout the continuum of care, from hospital settings to home recovery.

Behaivior

Grant in 2018
Behaivior LLC is a digital health company based in Pittsburgh, Pennsylvania, focused on predicting and preventing addiction relapses through innovative technology. Founded in 2017, Behaivior develops a platform that combines wearable devices and machine learning algorithms to monitor key physiological signals such as heart rate and motion. This system, known as Recovery, is designed to support mental health recovery and wellness by delivering timely interventions based on real-time data. By utilizing a software-as-a-service (SaaS) model, Behaivior empowers individuals to maintain their recovery process while enabling care providers to better assist their clients. The integration of AI and behavioral health technology allows Behaivior to recognize patterns in human behavior, ultimately aiming to enhance mental well-being and reduce the incidence of crises, including relapse.

Modulim

Grant in 2017
Modulim is a leader in light-based imaging technology focused on tissue and vascular assessment through spatial frequency domain imaging (SFDI). The company has developed the Clarifi Imaging System, which aids clinicians in identifying patients at risk for complications such as diabetic foot ulcers and amputations due to compromised circulation. By enabling timely interventions, this technology plays a crucial role in preserving patients' limbs and lives. Additionally, Modulim's devices are applicable in research, aesthetics, and medicine, providing professionals with transformative tools for the prevention, diagnosis, and treatment of various medical skin conditions.

BioSensics

Grant in 2017
Wearable sensors are transforming healthcare by empowering health researchers, care providers, and patients with new insights.Together with their clinical research and enterprise partners, They develop innovative, market driven, wearable sensor solutions that address some of healthcare’s biggest challenges.

Mobile Sense Technologies

Grant in 2017
The traditional diagnostic market is being transformed by advances in high performance wearables. This seismic shift led by consumer products which are uncovering new patients who previously went undetected, but still require a detailed diagnosis. Mobile Sense™ is building foundational technology that enables this transformation through off-the-chest wearables for long term management of cardiac arrhythmias. Developed over 7 years with $4.2M in grant funding and $1.3M in seed funding, Mobile Sense™ has a platform for differentiated wearables. Our embedded algorithms coupled with non-adhesive, wireless & waterproof sensors provides high fidelity continuous ECG and PPG recordings. The automatic monitoring provides 24/7, 365 days/yr continuous detection and classification of dangerous heart arrhythmias.

ReThink Medical

Grant in 2016
ReThink Medical, Inc. is a medical device and digital health company based in San Francisco, California, specializing in the development of a wrist-worn monitoring device. Founded in 2010 and now a subsidiary of Terumo Corporation, ReThink Medical focuses on predicting and preventing heart failure hospitalizations through continuous physiological monitoring and advanced machine learning algorithms. Its flagship product, CorBand™, is designed to detect and notify users of worsening heart conditions weeks in advance, even before noticeable symptoms emerge. This proactive approach emphasizes compliance, simplicity, and accuracy, aiming to improve quality of life for patients while significantly reducing healthcare costs. The device monitors key indicators such as heartbeat rate and fluid status, enabling timely intervention and management of heart-related disorders.

Epitel

Seed Round in 2016
Epitel is a digital health company focused on developing a wearable, wireless EEG monitoring platform aimed at improving seizure detection. The company offers a brain health monitoring device that accurately identifies abnormal brain activities using a proprietary cloud-based wearable sensor system combined with advanced artificial intelligence technologies. This innovative approach provides accessible, affordable, and reliable electrographic seizure detection, allowing physicians, caregivers, and patients with neurological disorders to gain valuable insights into brain health. By enhancing the quality of life and care for individuals affected by these conditions, Epitel strives to make significant contributions to the field of digital health.

Chrono Therapeutics

Grant in 2015
Chrono Therapeutics Inc. is a pharmaceutical company based in Hayward, California, specializing in digital transdermal drug delivery systems. Founded in 2003, the company has developed SmartStop, a digital nicotine replacement therapy that incorporates a wearable device. This innovative solution allows for programmable delivery of nicotine, adjusting timing and dosage to effectively manage withdrawal symptoms and peak addiction triggers. By combining this transdermal therapy with real-time behavioral support, Chrono Therapeutics aims to enhance smoking cessation efforts and improve clinical outcomes for users. The leadership team brings extensive experience in product development, research and development, and a deep understanding of the smoking cessation market, positioning the company to play a significant role in addressing the smoking epidemic.

UroDev Medical

Grant in 2015
UroDev Medical is focused on designing innovative medical devices to enhance the quality of life for individuals with spinal cord injuries and diseases. The company's flagship product, The Connected Catheter, introduces a semi-permanent, minimally-invasive smart catheter system that measures bladder pressure and wirelessly transmits data to a smartphone. This technology aims to simplify bladder management for millions of users by eliminating the need for intermittent catheters and drainage bags. The system allows both users and clinicians to control a valve that facilitates the emptying of urine from the bladder into the catheter, thereby improving overall bladder care and user experience.

Epitel

Grant in 2014
Epitel is a digital health company focused on developing a wearable, wireless EEG monitoring platform aimed at improving seizure detection. The company offers a brain health monitoring device that accurately identifies abnormal brain activities using a proprietary cloud-based wearable sensor system combined with advanced artificial intelligence technologies. This innovative approach provides accessible, affordable, and reliable electrographic seizure detection, allowing physicians, caregivers, and patients with neurological disorders to gain valuable insights into brain health. By enhancing the quality of life and care for individuals affected by these conditions, Epitel strives to make significant contributions to the field of digital health.
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