National Institutes of Health

The National Institutes of Health (NIH) is a leading biomedical research facility in the United States, operating under the Department of Health and Human Services. Established in 1887 and based in Bethesda, Maryland, NIH is the primary agency responsible for biomedical and health-related research in the country. It comprises 27 separate institutes and centers, each focusing on different disciplines within biomedical science. NIH conducts its own scientific research through the Intramural Research Program and provides significant funding for research at external institutions via the Extramural Research Program. With a workforce that includes 1,200 principal investigators and over 4,000 postdoctoral fellows, NIH has been instrumental in major medical breakthroughs, such as the development of vaccines for hepatitis and human papillomavirus, as well as the discovery of treatments for various health conditions. As the world's largest source of medical research funding, NIH continues to advance scientific knowledge and contribute to public health improvements.

Francis Collins

Director

Nick Langhals

Supervisory Program Director

Past deals in Midwestern US

University of Michigan

Grant in 2024
The University of Michigan’s programs consistently places high in national rankings. Especially renowned are the Stephen Ross School of Business, the College of Engineering, The Law and Medical Schools, and the Musical Theatre program. There is also a strong film presence in Ann Arbor, with many major motion pictures being shot there and the annual Ann Arbor Film Festival, which brings in filmmakers from all over the world.

Lamassu Pharma

Grant in 2024
Lamassu Pharma is a biotech startup dedicated to addressing the significant unmet medical need for severe acute pancreatitis. The company is focused on developing a novel small molecule therapy that has shown promising preclinical results in significantly reducing both mortality and morbidity associated with this condition. This therapeutic candidate, developed by leading scientists at Mayo Clinic, aims to improve medical outcomes for patients suffering from acute pancreatitis. Lamassu Pharma is currently advancing the development of this compound through safety testing, preparing for future clinical trials with the ultimate goal of saving lives and enhancing treatment options for those affected by this serious disease.

Neurodon

Grant in 2023
Neurodon Corporation is focused on discovering and developing disease-modifying therapies for intractable diseases by addressing endoplasmic reticulum (ER) stress, a significant factor in cell dysfunction and death. The company's innovative approach utilizes first-in-class modulators to restore calcium levels in cells, enabling the creation of therapeutics for conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and diabetes. Founded in 2019 and based in Crown Point, Indiana, Neurodon has advanced two candidates into IND-enabling studies, with plans to commence clinical trials in 2025. The company has raised over $11 million through various funding sources, including grants and partnerships, and is currently seeking additional funding to support its upcoming clinical studies. Neurodon’s unique platform technology positions it as a leader in addressing diseases linked to ER stress, with no direct competitors targeting the same mechanism of action.

University of Minnesota Medical School

Grant in 2023
University of Minnesota Medical School educates students, provides patient care, and performs biomedical and clinical research. UMN Medical School offers medical, graduate, and undergraduate degree programs, as well as continuing professional development. The Medical School has two campuses based in the Twin Cities and Duluth, Minnesota. The Twin Cities campus is an interdisciplinary research center. The Duluth campus educates 130 first and second-year medical students committed to practicing in rural or American Indian communities.

Avera McKennan Hospital School of Radiologic Technology

Grant in 2023
The Avera McKennan Hospital School of Radiologic Technology in Sioux Falls, South Dakota, offers a 24 month Radiologic Technology program that is rooted in the Roman Catholic healing ministry of the Gospel. Avera McKennan strives to produce students who uphold Christian values throughout their medical career. The school's academics are designed to prepare students to take the American Registry of Radiologic Technology's certification exam. To be qualified to sit for the exam, students must have earned an associate's degrees. Since this degree does not have to be in Radiologic Technology, Avera McKennan participates with a number of colleges and universities throughout South Dakota to help its students earn their credentials to take the exam. Your instruction will be delivered through lectures, demonstrations and guided clinical experiences at the Sioux Falls Veterans Administration Center. Since your education will be completed in real hospitals, you will gain valuable work experience during your college life to prepare you for the demands of the career. Avera McKennan's coursework emphasizes the healing power of Christ's ministry. Students are expected to embody these qualities and be willing to dedicate their lives to helping others. To apply, students must submit an application, high school or college transcript, ACT scores and three letters of recommendation. Admissions are determined based on upon an applicant's character and willingness to succeed. For information on the availability of financial aid and other tuition assistance programs, please contact Avera McKennan.

Michigan State University

Grant in 2023
Michigan State University is an educational institution that offers undergraduate, graduate, and research programs in the fields of business, humanities, science and technology, and public affairs. The schools and colleges of the university include College of Agriculture and Natural Resources, College of Arts and Letters, Eli Broad College of Business and The Eli Broad Graduate School of Management, College of Education, College of Human Ecology, College of Engineering, College of Human Medicine, College of Nursing, College of Osteopathic Medicine, College of Social Science, College of Veterinary Medicine, and College of Natural Science. Michigan State University was founded in 1855 and is based in East Lansing, Michigan.

Medical College of Wisconsin

Grant in 2023
The Medical College of Wisconsin, established in 1893 and located in Milwaukee, is dedicated to advancing education and research in the biomedical and health sciences. It offers a range of graduate programs, including bioethics, healthcare technologies management, and pharmacology. The institution employs a unique Discovery Curriculum that emphasizes personalized learning experiences, combining classroom instruction with clinical practice under the guidance of experienced faculty. The college is also home to the Student Teaching Assessment Resource Center, where students and medical professionals can hone their clinical skills using advanced medical simulators. The college's endowment fund, supported by donations and alumni gifts, provides essential funding for research, departmental initiatives, and scholarships. The Medical College of Wisconsin aims to improve community health and cultivate the next generation of healthcare professionals, while also offering financial aid options to students.

The Indiana CTSI

Grant in 2023
The Indiana CTSI is dedicated to leveraging and strengthening the state’s life sciences community to achieve better health for people in Indiana.Leadership and staff at the Indiana CTSI are working to develop the best processes and resources to enable the efficient translation of scientific discoveries to patient care.Indiana CTSI programs and partnerships are designed to educate, attract and retain top research talent in the state for generations to come.

Cleveland Clinic Innovations

Grant in 2023
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

Case Western Reserve University

Grant in 2022
Case Western Reserve University, located in Cleveland's University Circle, is an independent research institution established in 1843. It encompasses various schools and colleges, including the School of Medicine, School of Law, Case School of Engineering, College of Arts and Sciences, Frances Payne Bolton School of Nursing, Mandel School of Applied Social Sciences, School of Dental Medicine, and Weatherhead School of Management. The university is known for its excellence in medical education and biomedical research, with the School of Medicine recognized for its contributions to medical discoveries and training future physicians. The School of Law offers nationally ranked programs in international law, health law, and intellectual property law, integrating leadership courses and practical experiences into its curriculum. Case Western Reserve University is a member of the Association of American Universities and maintains full accreditation from the Higher Learning Commission, reflecting its commitment to educational quality and research excellence.

Cellular Logistics

Grant in 2022
Cellular Logistics, Inc. is a biotechnology company founded in 2016 and based in Madison, Wisconsin. The company specializes in developing an acellular biomaterial that serves as a stand-alone therapeutic for cardiac and tissue vascularization applications. This innovative biomaterial aims to significantly enhance cell survival rates and retention in regenerative medicine therapeutics. It also functions as a delivery mechanism for these therapies, improving post-injection cell retention and ultimately benefiting patients undergoing regenerative treatments.

Indiana University School of Medicine

Grant in 2022
The Indiana University School of Medicine is the largest medical school in the United States. The IU School of Medicine, which is made up of five fundamental science departments and twenty clinical departments, provides superior training for students interested in pursuing a medical degree. The school launched a new medical education curriculum with the Class of 2020 that better represents the modern U.S. health care environment and delivery methods, preparing students to practice medicine in a team-based, multidisciplinary setting.

Cleveland Clinic Innovations

Grant in 2022
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

Eastern Michigan University

Grant in 2022
Eastern Michigan University in Ypsilanti, Michigan, offers comprehensive academic and professional programs of study, including unique majors and those that are nationally recognized. Eastern Michigan’s undergraduate programs encompass creative, scholastic and career-oriented fields. Some examples of Eastern Michigan’s diverse majors include: * Art History * Aviation Flight Technology * Creative Writing * Japanese Language and Culture * Public Relations * Social Work Eastern Michigan also offers such unique majors and graduate degrees as: * Arts Management * Children’s Literature and Theatre * Music Therapy * Orthotics and Prosthetics Dual bachelor’s and master’s degrees are also available in such fields as Occupational Therapy. Eastern Michigan’s academics are also of high quality, with some of its programs, like Special Education and Forensics, ranking well nationally. College life at Eastern Michigan is comprehensive, including more than 200 student organizations and clubs. Ypsilanti is also a short distance from both the lively college town of Ann Arbor as well as the concerts and attractions of Detroit. First-time freshmen will need to submit an application with transcripts or a GED score and ACT or SAT scores. A minimum GPA of 2.0 is generally required. Financial aid awards include need-based programs like federal grants and loans. Eastern Michigan also offers more than 30 scholarships. Each scholarship has different eligibility requirements, which could include everything from grades and test scores to financial need to community service involvement.

Michigan State University

Grant in 2021
Michigan State University is an educational institution that offers undergraduate, graduate, and research programs in the fields of business, humanities, science and technology, and public affairs. The schools and colleges of the university include College of Agriculture and Natural Resources, College of Arts and Letters, Eli Broad College of Business and The Eli Broad Graduate School of Management, College of Education, College of Human Ecology, College of Engineering, College of Human Medicine, College of Nursing, College of Osteopathic Medicine, College of Social Science, College of Veterinary Medicine, and College of Natural Science. Michigan State University was founded in 1855 and is based in East Lansing, Michigan.

Cytonus Therapeutics

Grant in 2021
Cytonus Therapeutics, Inc. is a biotechnology company founded in 2018 and based in Columbus, Ohio. The company focuses on developing immune-oncology and gene therapies aimed at treating devastating and rare diseases. Cytonus combines artificial intelligence-driven drug discovery with a unique delivery system known as Cargocyte, which utilizes synthetic biology for precision treatment. The company's mission centers on addressing immune-related disorders through innovative approaches that enable targeted delivery and in vivo production of first-in-class therapeutics.

Northwestern University

Grant in 2021
Northwestern University is a prestigious institution located in Chicago, Illinois, offering a wide array of academic programs across various disciplines, including arts, science, engineering, and medicine. The university is committed to supporting students through financial aid options such as loans, grants, and scholarships, as well as providing resources for exam certification. Students at Northwestern have access to internships and job listings, enabling them to explore diverse majors and career paths. Additionally, the Northwestern University School of Law, established in 1859, offers specialized educational services in law, providing degrees such as Juris Doctor and Master in Law, along with various programs in executive and professional education, exchange, international, clinical, and graduate tax studies.

Cytonus Therapeutics

Grant in 2021
Cytonus Therapeutics, Inc. is a biotechnology company founded in 2018 and based in Columbus, Ohio. The company focuses on developing immune-oncology and gene therapies aimed at treating devastating and rare diseases. Cytonus combines artificial intelligence-driven drug discovery with a unique delivery system known as Cargocyte, which utilizes synthetic biology for precision treatment. The company's mission centers on addressing immune-related disorders through innovative approaches that enable targeted delivery and in vivo production of first-in-class therapeutics.

Indiana University

Grant in 2020
Indiana University, established in 1820 and located in Bloomington, Indiana, is a public research-intensive institution recognized for its commitment to liberal arts, sciences, and professional education. It focuses on creating, disseminating, preserving, and applying knowledge through innovative research, diverse educational programs, and meaningful extracurricular experiences. The university offers a wide range of undergraduate and graduate degrees, emphasizing professional, medical, and technological education while ensuring broad access for students from Indiana and beyond. Indiana University is dedicated to fostering a culturally diverse community and maintaining an environment that supports academic freedom and collegiality. Additionally, it plays a vital role in regional economic development and provides extensive academic and cultural resources to enhance student learning and engagement.

Ocuphire Pharma

Grant in 2020
Ocuphire Pharma is a clinical-stage biopharmaceutical company based in Farmington Hills, Michigan, that specializes in developing and commercializing therapies for various ophthalmic disorders. The company’s lead product candidate is Nyxol, a once-daily preservative-free eye drop formulation designed to treat conditions such as dim light vision disturbances, pharmacologically-induced mydriasis, and presbyopia. Nyxol is currently in late-stage clinical development, supported by extensive safety and efficacy data from previous trials. Additionally, Ocuphire is advancing APX3330, an oral tablet aimed at addressing diabetic retinopathy and diabetic macular edema, which is in Phase 2 clinical development. The company is also exploring opportunities to acquire further ophthalmic assets and seeks strategic partnerships for global commercialization of its products.

Cytonus Therapeutics

Grant in 2020
Cytonus Therapeutics, Inc. is a biotechnology company founded in 2018 and based in Columbus, Ohio. The company focuses on developing immune-oncology and gene therapies aimed at treating devastating and rare diseases. Cytonus combines artificial intelligence-driven drug discovery with a unique delivery system known as Cargocyte, which utilizes synthetic biology for precision treatment. The company's mission centers on addressing immune-related disorders through innovative approaches that enable targeted delivery and in vivo production of first-in-class therapeutics.

Cytonus Therapeutics

Grant in 2020
Cytonus Therapeutics, Inc. is a biotechnology company founded in 2018 and based in Columbus, Ohio. The company focuses on developing immune-oncology and gene therapies aimed at treating devastating and rare diseases. Cytonus combines artificial intelligence-driven drug discovery with a unique delivery system known as Cargocyte, which utilizes synthetic biology for precision treatment. The company's mission centers on addressing immune-related disorders through innovative approaches that enable targeted delivery and in vivo production of first-in-class therapeutics.

iotaMotion

Grant in 2020
iotaMotion, Inc. is a company based in Iowa City, Iowa, that specializes in the development and manufacture of cochlear ear implants aimed at treating hearing loss. Founded in 2015, the company has created a robotic-assisted surgical system designed to standardize the insertion of cochlear implant electrodes. This innovative technology enhances surgical precision by controlling the speed and acceleration of electrode insertion, which helps to reduce variability in surgical procedures. By personalizing the approach to each patient, iotaMotion enables surgeons to provide more accurate and tailored cochlear interventions, ultimately expanding access to these critical treatments for both patients and healthcare providers.

PhotoniCare

Grant in 2020
PhotoniCare, Inc. is a medical device company based in Champaign, Illinois, founded in 2013. The company specializes in developing innovative diagnostic tools for middle ear infections, notably the TOMi Scope. This handheld device employs advanced light-based technology, specifically near-infrared light waves, to create 3D images of the middle ear by seeing through the eardrum. This capability allows physicians to visualize the middle ear directly and safely, enabling them to assess its condition quickly and accurately. By determining the contents of the middle ear, clinicians can make informed decisions regarding the need for antibiotics or surgical interventions. PhotoniCare's technology not only addresses otology but also presents potential for growth in other medical fields.

Neurodon

Grant in 2020
Neurodon Corporation is focused on discovering and developing disease-modifying therapies for intractable diseases by addressing endoplasmic reticulum (ER) stress, a significant factor in cell dysfunction and death. The company's innovative approach utilizes first-in-class modulators to restore calcium levels in cells, enabling the creation of therapeutics for conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and diabetes. Founded in 2019 and based in Crown Point, Indiana, Neurodon has advanced two candidates into IND-enabling studies, with plans to commence clinical trials in 2025. The company has raised over $11 million through various funding sources, including grants and partnerships, and is currently seeking additional funding to support its upcoming clinical studies. Neurodon’s unique platform technology positions it as a leader in addressing diseases linked to ER stress, with no direct competitors targeting the same mechanism of action.

Cleveland Clinic Innovations

Grant in 2020
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

Cytonus Therapeutics

Grant in 2020
Cytonus Therapeutics, Inc. is a biotechnology company founded in 2018 and based in Columbus, Ohio. The company focuses on developing immune-oncology and gene therapies aimed at treating devastating and rare diseases. Cytonus combines artificial intelligence-driven drug discovery with a unique delivery system known as Cargocyte, which utilizes synthetic biology for precision treatment. The company's mission centers on addressing immune-related disorders through innovative approaches that enable targeted delivery and in vivo production of first-in-class therapeutics.

Cleveland Clinic Innovations

Grant in 2019
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

OmniLife

Grant in 2019
OmniLife, Inc. is a healthcare technology company based in Coralville, Iowa, that specializes in developing a mobile and web communication platform designed to enhance coordination between transplant patients and their care teams. Founded in 2016, OmniLife offers TXP Chat, a mobile messaging application that facilitates communication throughout the organ referral, allocation, procurement, and transplantation processes. The company aims to revolutionize care collaboration by serving a diverse network of healthcare providers, including hospital systems and group practices. Focusing initially on transplant hospitals and providers dealing with end-stage organ failure, OmniLife provides an integrated solution that addresses the entire workflow of transplant programs, from organ intake management to patient evaluation and waitlist management.

University of Illinois Chicago

Grant in 2019
A major research university in the heart of one of the world's greatest cities, UIC provides a world-class education for its students. We are committed to creating and disseminating new knowledge as a university of growing national and international stature. The largest university in the Chicago area, UIC has 27,580 students, 15 colleges-including the nation's largest medical school-and annual research expenditures exceeding $335 million. UIC operates the state's major public medical center and serves as the principal educator of Illinois' physicians, dentists, pharmacists, nurses and other health-care professionals. A truly global institution, more than a third of UIC students speak English as a second language. UIC's student body-approximately 61 percent undergraduate and 39 percent graduate and professional-is recognized as one of the nation's most diverse. We consider this one of our greatest strengths.

AgeneBio

Grant in 2019
AgeneBio, Inc. is a neuroscience pharmaceutical company founded in 2008 by Dr. Michela Gallagher, focused on developing therapeutic products for Alzheimer's disease, dementia, and other memory disorders. The company's primary targets include Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's disease (AD). AgeneBio aims to create innovative therapeutics that prevent neurodegeneration and preserve cognitive function in patients at risk for neurological and psychiatric conditions. By addressing the symptomatic pre-dementia stage of Alzheimer's disease and other related disorders, AgeneBio seeks to provide effective treatments for individuals facing these challenging health issues. The company is headquartered in Indianapolis, Indiana, and engages in global research and development efforts through various partnerships.

University of Missouri

Grant in 2019
University of Missouri (also known as Mizzou) in Columbia, Missouri, is one of the oldest public universities in the region. Today Mizzou has grown to offer more than 280 degree programs at the undergraduate and graduate levels, including those in medicine and other advanced professional fields. As a full-fledged university with much in the way of academics, research and college life offerings, Mizzou’s more than 30,000 students come from all over the country. Some of the more popular programs at the school include Journalism and Writing. Mizzou is also one of a small group of universities that offers Medicine, Law and Veterinary Medicine. Additional divisions include: *Agriculture *Arts and Sciences *Business *Education *Engineering *Nursing More than 600 student organizations also make their home at Mizzou, so that whatever a student’s interest is it can be found at Mizzou. In order to maintain itself as the competitive public university that it is, Mizzou has had to maintain fairly selective standards for admission. A great number of admitted students were valedictorians of their class or graduated in the top 10%. Mizzou considers grade point average, rigor of high school courses, SAT or ACT scores and other factors such as extracurricular involvement in its undergraduate admissions process. Graduate programs have individual requirements that may include course pre-requisites, undergraduate GPA and test scores. Students may be considered for academic merit scholarships awarded by the school. There are also federal aid sources such as Pell grants, loans and work-study to help those with a financial need to cover tuition costs. Veteran’s benefits are also offered.

Recovery Force

Grant in 2019
Recovery Force Health, LLC, based in Fishers, Indiana, specializes in the development and manufacturing of innovative health care apparel and wearable medical technology. Founded in 2013 by Matthew Wyatt, the company emerged from a personal experience where Wyatt sought to improve patient care following surgical procedures. Recovery Force offers a range of products, including sleeves and shoes, designed for healthcare professionals, patients, and athletes. Central to their offerings is the MORPH system, which utilizes S.M.A.R.T. technology and nitinol to provide rhythmic, sequential compression that enhances blood flow to targeted areas of the body. Their non-pneumatic platform aims to reduce post-operative pain and swelling, expedite wound healing, treat chronic lymphedema, and alleviate joint pain and muscle soreness. Recovery Force is committed to integrating data-driven solutions throughout the continuum of care, from hospital settings to home recovery.

Precision Virologics

Grant in 2019
Precision Virologics, Inc. is a biotechnology company focused on developing biologically targeted vaccines for emerging infectious diseases, including Zika. Established in 2016 and headquartered in Saint Louis, Missouri, the company utilizes an innovative technology based on adenoviral vectors that incorporate camelid antibodies aimed at activated dendritic cells. This approach allows for the precise delivery of proprietary antigen epitopes to target pathogens and offers significant advantages, such as reduced cross-reactivity among flaviviruses and enhanced potency. In addition to its Zika vaccine candidate, PV-ZIKV, Precision Virologics also aims to address other infectious diseases, including chikungunya and dengue, by harnessing its advanced vaccine development capabilities.

The University of Chicago Medicine

Grant in 2018
The University of Chicago Medicine is an academic medical institution that operates as a hospital which provides healthcare services. In addition, it provides medical education. The University of Chicago Medicine is comprised of the University of Chicago Pritzker School of Medicine; University of Chicago Biological Sciences Division; and University of Chicago Medical Center. The institution’s physicians are members of the University of Chicago Physicians Group which includes about 900 physicians and covers the full array of medical and surgical specialties. Its physicians are faculty members of the Pritzker School of Medicine. The University of Chicago Medicine was founded in 1927 and is based in Chicago, Illinois.

Novosteo

Grant in 2018
Novosteo Inc., founded in 2017 and located in West Lafayette, Indiana, focuses on developing and manufacturing innovative drugs aimed at treating bone injuries and diseases. The company addresses significant health issues related to bone fractures, including morbidity, mortality, and reduced mobility and productivity. Its scientific co-founders from Purdue University have pioneered a proprietary chemistry approach that targets bone regeneration. Novosteo's drug discovery platform features a range of fracture-targeted therapeutics designed to deliver healing agents directly to fracture sites, enhancing the healing process and alleviating the debilitating effects associated with bone injuries. Through its novel biologics, Novosteo aims to improve patient outcomes and quality of life.

Precision Virologics

Grant in 2018
Precision Virologics, Inc. is a biotechnology company focused on developing biologically targeted vaccines for emerging infectious diseases, including Zika. Established in 2016 and headquartered in Saint Louis, Missouri, the company utilizes an innovative technology based on adenoviral vectors that incorporate camelid antibodies aimed at activated dendritic cells. This approach allows for the precise delivery of proprietary antigen epitopes to target pathogens and offers significant advantages, such as reduced cross-reactivity among flaviviruses and enhanced potency. In addition to its Zika vaccine candidate, PV-ZIKV, Precision Virologics also aims to address other infectious diseases, including chikungunya and dengue, by harnessing its advanced vaccine development capabilities.

Neurodon

Grant in 2018
Neurodon Corporation is focused on discovering and developing disease-modifying therapies for intractable diseases by addressing endoplasmic reticulum (ER) stress, a significant factor in cell dysfunction and death. The company's innovative approach utilizes first-in-class modulators to restore calcium levels in cells, enabling the creation of therapeutics for conditions such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and diabetes. Founded in 2019 and based in Crown Point, Indiana, Neurodon has advanced two candidates into IND-enabling studies, with plans to commence clinical trials in 2025. The company has raised over $11 million through various funding sources, including grants and partnerships, and is currently seeking additional funding to support its upcoming clinical studies. Neurodon’s unique platform technology positions it as a leader in addressing diseases linked to ER stress, with no direct competitors targeting the same mechanism of action.

Intact Genomics

Grant in 2018
Intact Genomics is a world leader in large DNA fragment cloning and metagenomic technologies. We have dedicated scientists and state of the art equipment all housed in a modern facility, located in the Helix Center Biotech Incubator, next to Monsanto Headquarters, Donald Danforth Plant Science Center, and close to Washington University in St. Louis

The Indiana CTSI

Grant in 2018
The Indiana CTSI is dedicated to leveraging and strengthening the state’s life sciences community to achieve better health for people in Indiana.Leadership and staff at the Indiana CTSI are working to develop the best processes and resources to enable the efficient translation of scientific discoveries to patient care.Indiana CTSI programs and partnerships are designed to educate, attract and retain top research talent in the state for generations to come.

Kent State University

Grant in 2018
Kent State University, located in Kent, Ohio, is a prominent public doctoral university established in 1910, recognized for its high research activity. As the highest-ranking public university in Northern Ohio, it offers a diverse array of academic programs, including undergraduate majors in fields such as Biomedical Sciences, Communication Studies, Psychology, and Visual Communication and Design. Students have access to over 300 academic programs across Kent State's eight campuses and can participate in more than 200 student organizations, fostering a vibrant campus life. The university provides various financial aid options, including need-based awards and graduate assistantships, to support students in their educational pursuits. Admissions for freshmen require a minimum GPA and standardized test scores, though alternative pathways exist for those who do not meet these criteria. Kent State University plays a vital role in the educational landscape of Ohio, contributing to the development of its students through comprehensive academic and extracurricular offerings.

Humanetics Corporation

Grant in 2018
Humanetics is a privately held, clinical stage pharmaceutical company located in the Minneapolis metropolitan area. The Company was founded in 1988 and is engaged in developing and commercializing products to enhance human health and wellbeing. Humanetics entered the field of radiation modulators in 2003, through a cooperative research program with the Armed Forces Radiobiology Research Institute (AFRRI). Humanetics began working with AFRRI to test an array of drug candidates using their highly developed capabilities. From this program, BIO 300 emerged as a lead candidate and the underlying technology was in-licensed from AFRRI to Humanetics. In the ensuing years, the Company has progressed this program into multiple clinical uses with a primary focus on improving treatment of solid tumor cancers.

Artio Medical

Grant in 2018
Artio Medical, Inc. specializes in the development and commercialization of catheter-based medical devices aimed at treating cardiovascular diseases. The company offers a range of products, including Solus Gold and Solus Flex, which are embolization devices designed for precise and immediate vessel occlusion. Additionally, Artio Medical provides Aneura and Endura, which utilize a combination of coils and accessory balloons to effectively occlude saccular peripheral and cerebral aneurysms respectively. Founded in 2011, the company is headquartered in Prairie Village, Kansas, and operates as a subsidiary of Novita Therapeutics, LLC. Artio Medical's innovative medical devices enhance the safety, speed, and effectiveness of vascular occlusion procedures for healthcare professionals.

University of Illinois Chicago

Grant in 2018
A major research university in the heart of one of the world's greatest cities, UIC provides a world-class education for its students. We are committed to creating and disseminating new knowledge as a university of growing national and international stature. The largest university in the Chicago area, UIC has 27,580 students, 15 colleges-including the nation's largest medical school-and annual research expenditures exceeding $335 million. UIC operates the state's major public medical center and serves as the principal educator of Illinois' physicians, dentists, pharmacists, nurses and other health-care professionals. A truly global institution, more than a third of UIC students speak English as a second language. UIC's student body-approximately 61 percent undergraduate and 39 percent graduate and professional-is recognized as one of the nation's most diverse. We consider this one of our greatest strengths.

SentiAR

Grant in 2018
SentiAR, Inc. is a digital health company based in St. Louis, Missouri, specializing in 3D augmented reality solutions for interventional medical procedures. Founded in 2017 as a spin-off from Washington University, SentiAR has developed a platform that offers real-time holographic visualization of patients' anatomical structures and catheter locations. This technology integrates data from CT, MRI, and real-time mapping systems to create a controllable 3D holographic interface. The platform aims to enhance the delivery of care by allowing clinicians to visualize complex cardiac anatomy directly over the patient, thereby improving the treatment of cardiac arrhythmias during catheterization procedures. SentiAR is in the process of preparing its platform for submission to the FDA.

Cleveland Clinic Innovations

Grant in 2017
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

Washington University in St. Louis

Grant in 2017
Washington University in St. Louis will challenge you to realize your potential. They inspire and support each other with a view toward both individual and collective success. They are a community of individuals with inner fire and quiet confidence, inspired to work together to develop big ideas and tackle challenging problems. Their mission drives who they are as a university. As they accept the challenge of thier mission’s goals of inclusion and excellence, they are always evolving to meet the needs of their current and prospective students as well as thier alumni, faculty and staff. They focus on strategic priorities that produce the most impact toward their goal of enhancing the lives of their students, their community and their world. Their campuses demonstrate their commitment to an inclusive community that is welcoming, nurturing and intellectually rigorous. Throughout Washington University’s history they have set their sights high and judged their-selves by the most exacting standards. With a view toward individual and collective success, their mission moves us to inspire and support one another.

Nervive

Grant in 2017
Nervive is a stock-based Delaware C-corp that develops a new treatment for brain ischemia. Its primary product, VitalFlow Stimulator, is non-invasive platform technology that treats conditions of brain ischemia such as cerebral artery vasospasm, ischemic stroke, and traumatic brain injury. Founded in 2013, Nervive is headquartered in Akron, Ohio.

Cleveland Clinic Innovations

Grant in 2017
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

University of Michigan

Grant in 2017
The University of Michigan’s programs consistently places high in national rankings. Especially renowned are the Stephen Ross School of Business, the College of Engineering, The Law and Medical Schools, and the Musical Theatre program. There is also a strong film presence in Ann Arbor, with many major motion pictures being shot there and the annual Ann Arbor Film Festival, which brings in filmmakers from all over the world.

Fast Biomedical

Grant in 2017
Fast Biomedical is a clinical-stage medical technology company based in Indiana, dedicated to the development and commercialization of an innovative technology for quantifying critical health parameters that have historically been difficult to measure. The company's primary focus is on assessing blood volume and kidney function in a clinically viable manner. Fast Biomedical's technology utilizes a fluorescent compound to enhance the detection of kidney infections, allowing for faster identification of acute kidney failure compared to traditional lab tests. By injecting markers into a patient's bloodstream that fluoresce when analyzed with their device, physicians can more effectively monitor kidney health and improve patient outcomes.

ONL Therapeutics

Grant in 2017
ONL Therapeutics is a biopharmaceutical company focused on developing innovative therapeutics to protect and improve vision in patients with retinal diseases and conditions. Founded in 2006 and headquartered in Ann Arbor, Michigan, the company specializes in creating photoreceptor protective agents that target the FAS apoptotic pathway. Its drug programs aim to safeguard photoreceptors, thereby enhancing outcomes for patients undergoing surgeries related to retinal detachment and other serious vision-threatening issues. Through its research and development efforts, ONL Therapeutics seeks to provide effective solutions for preserving sight and improving the quality of life for individuals affected by these conditions.

Indiana University

Grant in 2017
Indiana University, established in 1820 and located in Bloomington, Indiana, is a public research-intensive institution recognized for its commitment to liberal arts, sciences, and professional education. It focuses on creating, disseminating, preserving, and applying knowledge through innovative research, diverse educational programs, and meaningful extracurricular experiences. The university offers a wide range of undergraduate and graduate degrees, emphasizing professional, medical, and technological education while ensuring broad access for students from Indiana and beyond. Indiana University is dedicated to fostering a culturally diverse community and maintaining an environment that supports academic freedom and collegiality. Additionally, it plays a vital role in regional economic development and provides extensive academic and cultural resources to enhance student learning and engagement.

Stem Pharm

Grant in 2017
Stem Pharm, founded in 2015 and located in the Fitchburg Technology Campus near the University of Wisconsin, specializes in providing synthetic biomaterials tailored for advanced cellular models. The company focuses on developing stem cell-derived in vitro models of the central nervous system, which are utilized in drug discovery and toxicology applications. Its innovative biomaterials, crafted from functionalized multi-arm polyethylene glycol monomers and bioactive peptides, form hydrogels that facilitate cell-based assays for disease modeling and drug testing. By leveraging its expertise in biomaterials and cellular interactions, Stem Pharm aims to enhance the development of organoids and create cell-friendly coatings for cell-based therapies in regenerative medicine.

Cleveland Clinic Innovations

Grant in 2016
Cleveland Clinic Innovations (CCI) is the commercialization arm of the Cleveland Clinic, established in 2000 and based in Cleveland, Ohio. It focuses on transforming the innovative inventions of Cleveland Clinic employees into medical products that benefit patients. CCI aims to create new business opportunities that extend the Cleveland Clinic's capabilities into the commercial market while fostering economic growth in Northeast Ohio and beyond. The organization promotes an inclusive entrepreneurial environment, encouraging participation from a diverse range of stakeholders, including physicians, nurses, researchers, and administrators. CCI employs a comprehensive approach that features deal teams, domain experts, investment funds, and incubation facilities, all designed to support the development and commercialization of new medical technologies. Through these efforts, CCI facilitates the creation of companies and the deployment of advancements in healthcare.

Intact Genomics

Grant in 2016
Intact Genomics is a world leader in large DNA fragment cloning and metagenomic technologies. We have dedicated scientists and state of the art equipment all housed in a modern facility, located in the Helix Center Biotech Incubator, next to Monsanto Headquarters, Donald Danforth Plant Science Center, and close to Washington University in St. Louis

Mayo Clinic

Grant in 2016
Mayo Clinic, established in 1864 and based in Rochester, Minnesota, is a not-for-profit medical group practice that offers a comprehensive range of medical care, education, and research services. It specializes in various fields, including diabetes and endocrinology, gastroenterology, gynecology, cancer treatment, neurology and neurosurgery, orthopedics, pulmonology, rheumatology, nephrology, urology, and cardiology and heart surgery. Mayo Clinic is dedicated to improving patient outcomes through innovative medical research and education in clinical medicine and the medical sciences. The organization collaborates closely with physicians and scientists to develop solutions that address pressing health challenges, ensuring that advancements in healthcare reach those who need them most.

KinaSense

Grant in 2016
KinaSense LLC is a biotechnology company based in West Lafayette, Indiana, focused on developing products for the pre-clinical and clinical phases of cancer drug discovery. Founded in 2013, the company specializes in cancer diagnostic solutions, particularly in the area of tyrosine kinase inhibitors (TKIs), which are widely used to treat various types of cancer. KinaSense is dedicated to creating technologies that enhance the predictive power of current diagnostic tools, aiming to determine which patients are most likely to benefit from specific TKIs. Their offerings include assays and cell-based kits designed to measure the efficacy and selectivity of TKIs, ultimately enabling a more personalized approach to cancer treatment.

Stemina Biomarker Discovery

Grant in 2015
Stemina Biomarker Discovery, Inc., a metabolomics company, focuses on the discovery, development, and commercialization of molecular biomarkers to improve drug safety and human health. The company works on collaborative research projects and joint development agreements with strategic partners to develop drugs, identify targets, and discover molecular biomarkers for the diagnosis of diseases and customized treatment. It provides metabolomics and mass spectrometry services, as well as develops diagnostic biomarkers. The company's cell-based assays arise from the strategic convergence of technologies, such as human embryonic stem (hES) cells and metabolomics. It uses mass spectrometry to analyze the small molecules secreted by hES, heart, and neural cells in response to drugs, injury, or disease. Stemina Biomarker Discovery, Inc. was founded in 2006 and is based in Madison, Wisconsin.

Isto Technologies

Grant in 2015
ISTO Technologies, Inc., an orthobiologics company, develops biologic products to regenerate and restore function to damaged cartilage and bone. It offers InQu, a resorbable bone graft extender and substitute; NuQu, a cell-based injectable therapy for disc regeneration; and DeNovo ET, an engineered cartilage implant for the repair and regeneration of knee cartilage. The company provides its products through distributors. ISTO Technologies, Inc. was founded in 1997 and is based in St. Louis, Missouri.

Sterilucent

Venture Round in 2015
Sterilucent is a health care company that develops and markets vaporized (gas) hydrogen peroxide technology offering effective and innovative sterilization products. Their products ensure that medical devices are safe and properly presented for patient procedures. The company was founded in 2004 and is headquartered in Minneapolis, Minnesota.

Mayo Clinic

Grant in 2014
Mayo Clinic, established in 1864 and based in Rochester, Minnesota, is a not-for-profit medical group practice that offers a comprehensive range of medical care, education, and research services. It specializes in various fields, including diabetes and endocrinology, gastroenterology, gynecology, cancer treatment, neurology and neurosurgery, orthopedics, pulmonology, rheumatology, nephrology, urology, and cardiology and heart surgery. Mayo Clinic is dedicated to improving patient outcomes through innovative medical research and education in clinical medicine and the medical sciences. The organization collaborates closely with physicians and scientists to develop solutions that address pressing health challenges, ensuring that advancements in healthcare reach those who need them most.

North Dakota University

Grant in 2014
The University of North Dakota, located in Grand Forks, is a prominent doctoral research institution established in 1883. It offers a diverse array of more than 300 academic programs, including notable disciplines such as aerospace sciences, which trains highly skilled pilots. The university fosters a vibrant student life with over 200 clubs and organizations, catering to a wide range of interests. Students benefit from a dynamic campus environment featuring events like career fairs, international food festivals, and creative writing activities. Admissions require the submission of an application, official transcripts, and standardized test scores, with lower tuition rates for North Dakota residents. Financial aid options include federal grants, loans, and scholarships, emphasizing support for students through early FAFSA completion. The university's leadership is committed to maintaining academic excellence and integrity, guided by a strategic vision for its academic mission.

IntelliWheels

Grant in 2014
IntelliWheels, Inc., is a startup company out of the University of Illinois at Urbana-Champaign that develops technology to improve mobility options for wheelchair users.

Northwestern University

Grant in 2014
Northwestern University is a prestigious institution located in Chicago, Illinois, offering a wide array of academic programs across various disciplines, including arts, science, engineering, and medicine. The university is committed to supporting students through financial aid options such as loans, grants, and scholarships, as well as providing resources for exam certification. Students at Northwestern have access to internships and job listings, enabling them to explore diverse majors and career paths. Additionally, the Northwestern University School of Law, established in 1859, offers specialized educational services in law, providing degrees such as Juris Doctor and Master in Law, along with various programs in executive and professional education, exchange, international, clinical, and graduate tax studies.

TCARE

Grant in 2014
TCARE, Inc. is a company that develops a caregiver support software-as-a-service (SaaS) solution aimed at preventing burnout among family caregivers. Its cloud-based platform allows care professionals to assess risk factors associated with caregiver burnout and implement timely interventions to mitigate these risks. By providing evidence-based support, TCARE's solution helps delay or prevent the need for nursing home placements, thereby reducing long-term care claims for Medicaid and life insurance providers. Founded in 2017 and based in Saint Louis, Missouri, TCARE serves a range of clients, including care organizations, professionals, and family caregivers across the United States.

University of Nebraska Medical Center

Grant in 2013
In addition to providing training for today’s leading medical and healthcare fields, University of Nebraska Medical Center (UNMC) is at the forefront of major research activities. Located in Omaha, Nebraska, UNMC is particularly well known and respected for its programs in Nursing, Pharmacy, Physical Therapy and Physician Assisting. UNMC also has a medical and dental school that trains future doctors and dentists. In addition to offering high-quality medical education, UNMC conducts hundreds of research projects yearly at its Durham Research Centers. Research activities include discoveries and contributions in such areas as cancer treatments and transplant medicine. Since the student population remains relatively small, both classes and research activities take place in small groups, giving students the chance to work with faculty members, who are leaders and pioneers in their field. Additional healthcare education programs include training for such fields as Clinical Laboratory Science, Cytotechnology, Medical Sonography and Radiation Therapy. Each program has its own admission requirements. Students may also apply for funding through research assistantships and fellowships.

Washington University School Of Medicine

Grant in 2013
Washington University School of Medicine is the medical school of Washington University in St. Louis.A leader in medical research, teaching and patient care, Washington University School of Medicine is currently ranked fourth in the nation by U.S. News & World Report. The School’s 2,100 employed and volunteer faculty physicians and clinicians -- known as Washington University Physicians -- are also medical staff members of Barnes-Jewish and St. Louis Children’s hospitals. The clinical practice group provides care to more than 430,000 children and adults at 49 clinical sites annually. Together, the institutions located on the Washington University Medical Center campus employ more than 21,000 clinicians, scientists, residents, fellows, administrators and support staff.

NeoClone

Grant in 2012
NeoClone is a research-focused company established in 1999 by three scientists from the University of Wisconsin, specializing in the development of monoclonal antibodies for biotechnology and research applications. The company employs retroviral transformation technology to produce these antibodies, which allows for faster development times and cost savings. By leveraging this innovative platform, NeoClone is able to deliver customized antibodies to researchers and scientists more efficiently, enhancing the capabilities of research in the field of antibody technologies.

Promentis Pharmaceuticals

Grant in 2012
Promentis Pharmaceuticals discovers, develops, and markets new drugs for the treatment of important human diseases, focusing initially on developing a new antipsychotic drug to treat schizophrenia. Promentis Pharmaceuticals was founded in 2006 and is based in Milwaukee, Wisconsin.

AquaMost

Grant in 2011
AquaMost, Inc. is a Madison, Wisconsin-based company specializing in chemical-free water treatment solutions. Its flagship product, the SX Reactor, employs a combination of onsite generation of chlorine, hydroxyl radicals, and ultraviolet irradiation to effectively eliminate bacteria from various water sources, achieving a kill rate of over 99%. This patented technology is particularly beneficial for the oil and gas industry, where it helps treat flowback and produced water, as well as in other sectors such as food and beverage, dairy, and drinking water treatment. AquaMost provides comprehensive services, including delivery, setup, and maintenance of its systems, which have been deployed in regions like Texas, Colorado, Utah, and Canada. Established in 2006, the company focuses on delivering innovative water purification solutions without the use of chemicals.
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