MedTech Innovator

Samay specializes in remote respiratory health management. It develops AI-enabled wearable devices that monitor pulmonary volumes, trapped air, heart rates, breathing sounds, and lung temperature. This enables users to analyze their respiratory data and helps prevent respiratory diseases.

FibriCheck is a medically certified software-as-a-medical-device that detects irregular heart rhythms, including atrial fibrillation, through a smartphone camera. The app operates as a software-only solution on prescription, enabling users to measure cardiac rhythm anywhere and anytime, with data automatically shared with a medical professional to support faster diagnosis and appropriate treatment plans. The company leverages artificial intelligence to locate and track heart rhythm issues and to assist in managing conditions such as high blood pressure and heart failure, aiming to revolutionize cardiovascular care and empower patients to monitor and manage their heart health efficiently.

Samay specializes in remote respiratory health management. It develops AI-enabled wearable devices that monitor pulmonary volumes, trapped air, heart rates, breathing sounds, and lung temperature. This enables users to analyze their respiratory data and helps prevent respiratory diseases.

IFPx develops an implantable patient monitoring device that directly analyzes fluid buildup in the body. This device aims to improve the management of chronic illnesses, initially focusing on heart failure.

3EO Health is dedicated to creating a society where individuals are empowered to enhance their health across various aspects of life, including patient care, community engagement, and personal well-being. The company develops innovative molecular point-of-care platforms that utilize advanced technology to significantly reduce costs while improving access to impactful diagnostic tools. By leveraging its proprietary 3TR technology, 3EO Health offers molecular performance that is more affordable than existing options, ensuring equitable access to high-quality health solutions for both physicians and consumers. Its mission extends beyond traditional healthcare settings, aiming to integrate health optimization into communities, workplaces, and homes, thus fostering an environment where individuals can thrive.

NXgenPort develops digital health technology for remote monitoring of cancer patients between chemotherapy visits. Its Smart Port device measures cell counts and heart function in vivo, alerting physicians to signs of infection and reducing hospitalizations. This data also improves patient outcomes and provides valuable insights for cancer researchers.

Proton Intelligence develops a wearable device that monitors potassium levels in real-time via interstitial fluid, closely correlated to blood. This enables clinicians and patients to manage medications and diets effectively for improved heart and kidney care, particularly targeting hyperkalemia in chronic kidney disease patients with co-morbidities.

SafeGuard Surgical is a medical device company focused on improving surgical outcomes and patient safety. It develops innovative, resorbable products designed to enhance colonic anastomotic healing and stability during advanced surgical procedures. These include a resorbable intraluminal stent graft and an extraluminal resorbable graft, along with anvil cap extension arms. By employing these products, SafeGuard aims to reduce surgical complications, lower healthcare costs, and minimize patient recovery time, ultimately preventing mortality and morbidity associated with surgery.

Hertility Health is a women's health company specializing in reproductive healthcare. It offers unique diagnostic testing, expert advice, and educational resources, enabling women to manage their fertility and hormonal health from home.

Phagenesis develops a medical device for treating dysphagia, a swallowing disorder often resulting from stroke or brain injury. The device, Phagenyx, uses neurostimulation therapy to harness the brain's capacity for relearning lost functions via neuroplasticity. It consists of a base station and a catheter inserted through the nose, delivering optimal stimulations to the pharynx while recording patient data.

Augment Health is a company focused on developing noninvasive medical devices and artificial intelligence algorithms to enhance the management of bladder dysfunction, particularly for the 7 million patients affected by neurologic disease or injury. The company's innovative technology allows for monitoring urine levels through a device that can be attached to catheters, providing timely notifications to users or care providers when the catheter reaches capacity. This approach aims to shift bladder diagnostics from clinical settings to patients' homes, addressing the high rate of inconclusive test results associated with traditional in-clinic diagnostics. By enabling better bladder health management, Augment Health seeks to prevent complications such as bladder muscle atrophy, ultimately improving the quality of life for patients.

52 North Health develops an AI-powered medical device for determining neutropenic sepsis risk in chemotherapy patients. Its portable finger-prick blood test measures neutrophil count and C-Reactive Protein (CRP) levels at home, enabling early detection and improved management of this fatal side effect.

CardiaCare is a medical device company focused on neuromodulation therapy for atrial fibrillation. Its wearable device provides non-invasive treatment and at-home monitoring, utilizing a closed-loop system and machine learning to deliver personalized peripheral neuromodulation that aims to mediate a cardiovascular antiarrhythmic response, reduce the burden of atrial fibrillation and its precursors, and offer rapid clinical and symptomatic relief.

LiveMetric is a medical device company focused on developing innovative, non-invasive sensing and deep data analytics solutions aimed at improving the management of hypertension and cardiovascular diseases. The company offers a wearable, cuff-free device for blood pressure monitoring that is FDA-cleared and validated for accuracy against traditional arterial line methods. This technology provides high-fidelity arterial pressure waveforms and continuous tracking of vital signs, allowing for real-time feedback and analysis for patients, physicians, and healthcare providers. By delivering personalized data and detailed activity mapping, LiveMetric aims to empower individuals, payors, self-insured employers, and healthcare providers, ultimately enhancing the care and quality of life for over one billion people worldwide affected by these conditions.

CARI Health develops wearable remote medication monitors that attach to the skin and continuously transmit data about medication levels to the cloud, enabling clinicians to prescribe medications and monitor real-time exposure. The sensor-enabled system supports personalized dosing by facilitating safe titration of therapies with narrow therapeutic windows, potentially improving dosing precision and patient outcomes. The company was founded in 2015 and is based in San Diego, California.

PyrAmes is a healthcare technology company that has created an innovative, paper-thin, flexible device for non-invasive blood pressure monitoring. This ultra low-power device is designed to deliver continuous and accurate blood pressure measurements wirelessly, making it suitable for patients of all ages, from newborns to seniors. PyrAmes aims to transform healthcare delivery by providing a platform that enables healthcare providers to conduct pain-free blood pressure monitoring, particularly benefiting vulnerable populations such as neonates.

Founded in 2018 and based in Redwood City, California, Bone Health Technologies designs and manufactures OsteoBoost, a wearable medical device that uses whole-body vibration technology to provide weight-bearing exercise and mechanical stimulation to the hips and spine. Clinically proven to slow bone density loss in postmenopausal women with osteopenia, OsteoBoost offers a convenient, non-pharmacological, pain-free treatment option for nearly 64 million Americans at risk of osteoporotic fractures.

Respirix, Inc. is a United States-based company focused on developing advanced analysis sensors for monitoring breath exhalation and cardiogenic oscillations. The company offers digital health software and hardware designed to provide proprietary insights into the pulmonary vasculature in a non-invasive manner. Respirix's product pipeline targets both at-home monitoring and critical care applications, specifically in areas such as heart failure and hemodynamics. Its innovative approach aims to enhance patient care by delivering precise and actionable data related to respiratory and cardiovascular health.

Koya Medical, Inc. is a healthcare company based in Oakland, California, founded in 2018. The company specializes in developing innovative wearable therapeutic devices aimed at treating cancer-related chronic lymphedema and various venous diseases. Koya Medical's technology offers active compression therapy that enhances mobility and personalized care, addressing limitations commonly associated with traditional compression methods. Its sensor-based closed-loop system provides patient-specific patterned compression, enabling healthcare providers to effectively manage conditions like chronic edema and chronic venous insufficiency. Through its breakthrough treatments, Koya Medical seeks to transform the standard of care for individuals affected by these debilitating conditions.

Sana Health, Inc. is a digital health company based in Lafayette, Colorado, with an additional office in Mill Valley, California. Founded in 2015, the company specializes in developing bio-therapeutic devices designed to promote relaxation and alleviate pain and tension. Its flagship product, Sana, is a non-addictive mask and headphone combination that utilizes audiovisual stimulation to enhance the balance between the left and right sides of the brain, facilitating a deep meditative state. This device employs coordinated pulses of light and sound to guide users into relaxation, mimicking the benefits of long-term meditation practices. Sana Health is also engaged in multiple clinical studies, focusing on applications for conditions such as fibromyalgia and neuropathic pain, as well as trials related to anxiety and PTSD. The company offers its products for sale online and provides a mobile application accessible via major app platforms.

Tasso, Inc., established in 2012 and based in Seattle, Washington, specializes in manufacturing clinical-grade, at-home blood sample collection devices. Their innovative product allows patients to conveniently and painlessly collect their own blood at home using a simple, push-button mechanism, and then mail the samples to a qualified lab for analysis. This approach aims to enhance accessibility and comfort in blood-based diagnostics, reducing the need for clinic visits.

Spire Health, established in 2013 and headquartered in San Francisco, specializes in developing health-tracking devices and remote patient monitoring solutions. The company's core product is a wearable device that senses physical movement, position, and breathing patterns, providing insights into daily activities and mental state through a mobile application. Spire Health focuses on chronic respiratory disease management, offering solutions for conditions such as COPD, congestive heart failure, asthma, and sleep disorders. Their mission is to empower patients and physicians with useful, actionable data by harnessing the power of algorithms and sensors, thereby improving health outcomes.

Enspectra Health, based in Mountain View, California, develops advanced imaging systems for medical research and diagnosis. Founded in 2012, the company has pioneered the world's first handheld multiphoton imager for human use, capable of visualizing beneath the skin in real-time. Its innovative system combines reflectance confocal and multiphoton laser scanning microscopy to generate multispectral images, enhancing dermatologists' ability to diagnose and treat skin conditions, particularly cancers. Enspectra Health delivers these imaging systems to researchers studying various tissues and has a track record of delivering such systems since its inception.

Patientory is a digital health data platform that enables individuals to store and manage personal medical records and health information, empowering patients to control their data. The platform securely manages records, offers AI-driven health coaching, tracks wellness metrics, connects users to clinical trials and affordable medications, and rewards healthy behaviors. It facilitates connections between patients and healthcare providers to support care coordination. Founded in 2015 and based in Atlanta, the company aims to streamline access to health information and enable patients to benefit from their data.

Spry Health, based in Palo Alto, California, develops digital health solutions aimed at improving care for chronically ill patients. The company offers a clinical-grade wearable device and a disease management platform that provides real-time analytics to healthcare payers. This technology helps manage patient conditions remotely, avoid preventable hospitalizations, and reduce overall healthcare spending by focusing on the small percentage of patients who account for a significant portion of health costs. Spry Health's solutions enhance timely care delivery through individualized analytics, ultimately improving patient outcomes and decreasing hospitalization rates. The company was incorporated in 2013.

SilverCloud Health, established in 2011, is a digital health company that develops and provides online therapeutic solutions via tailored clinical programs. Headquartered in Boston, Massachusetts, with offices in Dublin, Ireland, and London, UK, the company's SilverCloud platform offers evidence-based, supported digital therapies to various healthcare sectors. It aims to increase client/patient engagement and reduce program dropout rates, as demonstrated by a three-fold improvement in these metrics compared to leading online therapeutic products.

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Vixiar Medical, established in 2013 and headquartered in Annapolis, Maryland, specializes in developing non-invasive, cost-effective devices and systems for monitoring cardiopulmonary diseases. Its flagship product, Indicor, is a handheld point-of-care device and digital platform designed to monitor and manage worsening heart failure. Vixiar's devices aim to enhance clinical workflow and deliver economic value to the healthcare system by enabling monitoring in various settings, including homes, offices, nursing homes, and hospitals.

uBiome, Inc. was a microbial genomics company based in San Francisco, California, founded in 2012. It specialized in sequencing-based clinical microbiome tests, offering products such as SmartGut, a test for identifying pathogenic and commensal microorganisms related to infections, and SmartJane, a women's health screening test that detects various conditions including HPV and STIs. The company also provided Explorer kits for citizen scientists and researchers, as well as SmartFlu, a clinical respiratory test. By leveraging precision sequencing combined with machine learning and artificial intelligence, uBiome aimed to enhance the understanding of the human microbiome, enabling healthcare providers to deliver more accurate diagnoses and empowering patients to manage their health more effectively. However, uBiome faced financial difficulties and filed for Chapter 11 bankruptcy in September 2019, which was later converted to Chapter 7 on October 11, 2019.

HeadSense Medical Ltd. is an early-stage company based in Netanya, Israel, focused on developing non-invasive diagnostic devices for brain health. Founded in 2011, the company has created a validated intracranial pressure (ICP) monitor that has received CE Mark approval. This innovative device is utilized in various medical fields, including neurosurgery, neurology, emergency medicine, and critical care, providing physicians with essential tools to diagnose and monitor crucial clinical parameters. In addition to its ICP monitor, HeadSense is actively working on expanding its platform to include applications for diagnosing cerebral vasospasm, assessing concussion severity, and quantifying traumatic brain injury (TBI).

Founded in 2013, Aluna develops a portable spirometry device paired with an interactive iPhone game. Its health platform helps users track asthma symptoms, monitor medication, and provides real-time data sharing with doctors for personalized treatment plans.

Clear Ear Inc. is a privately held medical device company based in San Francisco, California, founded in 2011 through the Stanford Biodesign Program. The company specializes in designing, manufacturing, and selling innovative ear cleaning solutions, including the Oto-Tip, which targets the primary cause of hearing loss and hearing-aid failure: ear wax impaction. Clear Ear's product line, known as Total Ear Care (TEC), aims to enhance access to ear care for the 47 million Americans and over 350 million people globally affected by this issue. In addition to its main products, Clear Ear also offers replacement kits, bundles, refill packs, and water-resistant headphones, all available for purchase online.

Silver Medical focuses on enhancing sports safety through innovative medical technology aimed at detecting concussions. The company has developed a patented system that requires only a small drop of blood, similar to a glucose monitoring device used by diabetics. This technology analyzes the blood sample for fluctuations in a specific biomarker that rises quickly following a brain injury. By delivering real-time results, Silver Medical empowers coaches, players, and medical staff to make prompt and informed decisions regarding an athlete's ability to safely return to play after a suspected concussion.