Medtronic

CathWorks Ltd. is a medical technology company based in Kfar-Saba, Israel, with an additional office in the United States. Founded in 2013, CathWorks specializes in developing advanced medical devices for the interventional cardiology market. The company's innovative technology leverages computational science and automatic multi-layered algorithms to enhance the utility of coronary angiography data, transforming visual assessments into objective decision-making tools for physicians. Its flagship product, CathWorks FFRangio, is a non-invasive device that provides objective multi-vessel physiological measurements, aimed at optimizing and confirming intra-procedural decisions for percutaneous coronary interventions (PCI). CathWorks is privately held and benefits from strong partnerships and support from leading venture capital firms in the medical devices sector.

Orchestra BioMed, Inc. is a biomedical innovation company established in 2017 and located in New Hope, Pennsylvania. The company is dedicated to developing high-impact therapeutic solutions for medical procedures, with a primary focus on addressing cardiovascular diseases, which account for a significant number of global fatalities annually. Orchestra BioMed aims to accelerate the commercialization of its products through strategic partnerships with medical device companies. Its leading product candidates include BackBeat Cardiac Neuromodulation Therapy, designed for hypertension treatment, and Virtue Sirolimus AngioInfusion Balloon, which targets atherosclerotic artery disease. By emphasizing evidence-based solutions, Orchestra BioMed seeks to improve patient outcomes for serious medical conditions.

Titan Medical Inc. is a research and development stage company based in Toronto, Canada, that specializes in the design and development of robotic surgical technologies for minimally invasive surgery (MIS). The company's primary focus is on the SPORT Surgical System, a single-port robotic surgical system that features a surgeon-controlled patient cart equipped with a 3D high-definition vision system and multi-articulating instruments. This system allows surgeons to perform a variety of MIS procedures, including those related to gynecologic, urologic, colorectal, and abdominal conditions. The SPORT Surgical System includes an ergonomic surgeon workstation that provides a 3D endoscopic view of the surgical area, enhancing the overall surgical experience and precision.

Scivita Medical is a technology-focused enterprise specializing in optical diagnosis and treatment, as well as the development of multidimensional imaging and high-performance materials for minimally invasive medical procedures. The company offers a range of products, including flexible and rigid endoscopes, designed to enhance the capabilities of medical professionals. Its product lineup features advanced technologies such as ultra-high-definition visualization, 3D imaging, and fluorescence visualization, which facilitate precise diagnostics and treatments. Key offerings include a 4K medical endoscope camera system, integrated 4K-3D endoscope systems, and various single-use endoscopic devices for applications in gynecology, urology, and pulmonology. Scivita Medical aims to provide doctors with innovative tools that improve patient outcomes through enhanced visualization and minimally invasive techniques.

Ai Biomed is a technology that can detect the location of parathyroid tissue in real-time during surgical procedures, including during thyroidectomy and parathyroidectomy.

Triple Jump Medical is a developer of an insulin pump intended to treat diabetic patients.

BioProtect Ltd. is an international medical device startup focused on developing and commercializing biodegradable balloon spacers designed to protect normal tissue during cancer radiation therapy. The company's flagship product, the ProSpace balloon spacer, has demonstrated superior efficacy and safety in safeguarding the rectum during radiation treatment for prostate cancer. This innovative technology significantly reduces the risk of serious and chronic side effects associated with radiation, while enhancing tumor control. Founded in 2004 and headquartered in Israel, BioProtect also operates subsidiaries in Germany and the United States, aiming to address unmet clinical needs in the growing radiotherapy spacers market with its platform of biodegradable implantable balloons.

Companion Medical develops products to improve healthcare with easy-to-use medical devices that utilize state-of-the-art technologies. It has experience in medical devices and critical systems development, and its team is positioned to introduce exciting new medical products that improve and facilitate patient care. The company’s initial products focus on providing improved care to insulin using Diabetics.

Sinovation (Beijing) Medical Technology Co., Ltd. is a Beijing-based company that specializes in the research, development, production, and sale of medical devices. The company is dedicated to advancing medical robot technology and innovating intelligent medical products. Sinovation Medical's offerings include surgical robots that utilize clinical computer vision technology to enhance precision in medical procedures. These products are primarily designed for neurosurgical applications, addressing conditions such as epilepsy, Parkinson's disease, cerebral hemorrhage, and intracranial tumors. By providing reliable medical robotics, Sinovation aims to improve care for patients and support healthcare professionals in delivering effective treatment.

Medicrea International SA specializes in the design, manufacture, and distribution of spinal implants, operating both in France and internationally. Established in 1990 and headquartered in Rillieux-la-Pape, France, the company offers a comprehensive range of products, including various systems for thoraco-lumbar fixation, cervical interbody devices, and specialized implants for treating conditions such as scoliosis, degenerative diseases, and trauma. Notable product lines include the PASS series, which encompasses polyaxial and posterior fixation systems, as well as the IMPIX series, featuring sterile PEEK Optima cervical and lumbar interbody devices. Medicrea focuses on delivering innovative technologies aimed at improving patient outcomes and supporting healthcare professionals in surgical procedures. The company has been dedicated to advancing spinal care, leveraging over 18 years of experience in the field. As of late 2020, Medicrea operates as a subsidiary of Covidien Group S.a.r.l.

Klue, Inc. is a digital health technology company founded in 2016 and based in San Mateo, California. It specializes in developing artificial intelligence-based software that can recognize meals and analyze users' eating behaviors. Klue's innovative approach includes wearable technology aimed at addressing obesity by promoting healthier eating habits through real-time behavioral insights. As a subsidiary of Medtronic plc, Klue focuses on leveraging technology to empower individuals to make informed dietary choices and cultivate better eating patterns.

AV Medical is a company of medical devices that develops catheter-based interventions. It targets its flagship catheter, the Chameleon, to dialysis patients undergoing routine angioplasty procedures. It develops and commercializes the Chameleon PTA balloon catheter with its Supervision technology. The Chameleon catheter facilitates efficient angioplasty procedures and can potentially enhance both patient and operator safety. Experts have clinically he Chameleon has been clinically tested in various types of dialysis access procedures.

Saluda Medical Pty Ltd. is a medical device company focused on developing innovative solutions for the neuromodulation industry. The firm is known for its investigational device, Evoke, which features a closed-loop spinal cord stimulation system. This technology measures the spinal cord's response to stimulation and adjusts the stimulation parameters in real-time to optimize therapeutic outcomes for patients. Founded in 2010 and headquartered in Artarmon, Australia, with additional offices in Minnesota and the United Kingdom, Saluda Medical aims to provide effective treatment for chronic neuropathic pain. The company's unique approach involves monitoring each patient's neural fingerprint to automatically tailor electrical stimulation, ensuring that therapy is customized to meet individual needs. Saluda Medical's commitment to advancing medical technology is underpinned by a strong foundation of scientific research and a team of experienced professionals.

Mazor Robotics Ltd. is a medical device company specializing in the development, production, and marketing of surgical technologies for orthopedics and neurosurgery. Established in 2000 and headquartered in Caesarea, Israel, the company focuses on computer-assisted surgery, enabling high-precision and minimally invasive procedures. Its flagship products include the Mazor X and the Renaissance guidance systems, which significantly enhance the accuracy of spinal surgeries, leading to improved clinical outcomes. These systems are designed to support complex surgical procedures while providing a safer environment for patients and medical staff. With the majority of its revenue generated in the United States, Mazor Robotics continues to innovate in the field of spine surgery, raising the standard of care in surgical practices.

MC10, Inc. specializes in developing and selling wearable medical sensors that capture clinical-grade biometric and physiological data for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers several innovative products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, a rehabilitation device for orthopedic surgery; WiSP, which provides cardiac monitoring and ECG recording; and BioStampMD, a flexible sensor designed to conform to the human body for comprehensive data collection. The BioStamp system enhances data acquisition by allowing for discreet and comfortable wear, thus facilitating targeted measurements of muscle activation and movement. MC10's dedication to creating flexible, conformal electronics aims to improve the quality of life by seamlessly integrating technology with human activity.

Nanos Medical is engaged in the research and development, manufacturing and sales of disposable medical devices. The company's current core products are concentrated in the cardiovascular and ENT fields.

Yosemite Clinic is a multidisciplinary medical center located in Central Pudong, Shanghai, offering a wide range of walk-in services in a modern and well-equipped environment. The clinic provides specialties including family medicine, internal medicine, gynecology, pediatrics, rehabilitation, sports medicine, dentistry, ophthalmology, dermatology, and medical cosmetology. It is particularly noted for its focus on Minimally Invasive Surgery and Ambulatory Surgery. The facility is equipped with advanced medical imaging technology, including CT, X-ray, and ultrasound, alongside a fully operational laboratory and pharmacy. The clinic's diverse team of healthcare professionals hails from both China and around the world, allowing them to offer services in multiple languages such as English, Japanese, Malay, Mandarin Chinese, and Cantonese, ensuring comprehensive care for a diverse patient population.

VisionSense Corp. designs and develops advanced 3D-HD visualization systems specifically for minimally invasive surgeries. Its flagship products include the Visionsense VSiii system, which utilizes a stereoscopic camera for various surgical applications such as neurosurgery, ENT procedures, arthroscopy, and laparoscopy. Additionally, the Visionsense Iridium system provides inter-operative infrared fluorescence visualization to enhance surgical precision. The company's innovative technology offers depth perception and high-resolution imaging, allowing surgeons to navigate complex procedures with greater confidence and control. VisionSense serves medical centers globally, focusing on areas including neurosurgery, plastic and reconstructive surgery, and tumor margin visualization. Founded in 1998 and headquartered in Philadelphia, Pennsylvania, VisionSense operates additional offices in New York and Petah-Tikva, Israel, and functions as a subsidiary of Medtronic plc.

Fire1, based in Dublin, Ireland, is dedicated to developing innovative therapeutic devices aimed at enhancing the lives of heart failure patients. The company has created a remote monitoring system that allows healthcare providers to access real-time patient data and insights. This technology facilitates the early detection of complications associated with heart failure, enabling proactive interventions that can lead to improved patient outcomes. Through its focus on remote monitoring, Fire1 seeks to address critical challenges in heart failure management and contribute to better healthcare solutions.

AEGEA Medical is pioneering the application of its Adaptive Vapor Ablation technology to deliver therapies that provide high quality patient outcomes to a wider range of patients. AEGEA’s FDA approved water vapor technology enables the delivery of a safe and effective endometrial ablation for the treatment of menorrhagia in a simple, office-based procedure that takes only minutes. With a vision to expand safe and effective treatment options to more patients, and provide physicians with the confidence and convenience necessary to perform office-based procedures, AEGEA is inspiring new approaches to women’s healthcare. Founded in 2008, AEGEA Medical is located in in Menlo Park, California.

Crospon is developing edge minimally invasive medical devices for imaging and aiding surgery in the esophagus and stomach.

Mazor Robotics Ltd. is a medical device company specializing in the development, production, and marketing of surgical technologies for orthopedics and neurosurgery. Established in 2000 and headquartered in Caesarea, Israel, the company focuses on computer-assisted surgery, enabling high-precision and minimally invasive procedures. Its flagship products include the Mazor X and the Renaissance guidance systems, which significantly enhance the accuracy of spinal surgeries, leading to improved clinical outcomes. These systems are designed to support complex surgical procedures while providing a safer environment for patients and medical staff. With the majority of its revenue generated in the United States, Mazor Robotics continues to innovate in the field of spine surgery, raising the standard of care in surgical practices.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.

Saluda Medical Pty Ltd. is a medical device company focused on developing innovative solutions for the neuromodulation industry. The firm is known for its investigational device, Evoke, which features a closed-loop spinal cord stimulation system. This technology measures the spinal cord's response to stimulation and adjusts the stimulation parameters in real-time to optimize therapeutic outcomes for patients. Founded in 2010 and headquartered in Artarmon, Australia, with additional offices in Minnesota and the United Kingdom, Saluda Medical aims to provide effective treatment for chronic neuropathic pain. The company's unique approach involves monitoring each patient's neural fingerprint to automatically tailor electrical stimulation, ensuring that therapy is customized to meet individual needs. Saluda Medical's commitment to advancing medical technology is underpinned by a strong foundation of scientific research and a team of experienced professionals.

Forerunner Medical (Shanghai) Co., Ltd. develops and manufactures medical devices for minimally invasive treatment. It primarily develops and produces low-temperature plasma radiofrequency generators and electrodes for sport medicine, disk demo-pression, and ENT treatment applications. Its products include plasma radiofrequency systems; and electrodes for joint, spine, cervical, lumbar, transforaminal endoscopic operation, and ENT treatment applications. The company was founded in 2009 and is based in Shanghai, China.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

MD Start SA is a Swiss-based incubator and fund focused on the medical technology sector, established in 2009. The company specializes in transforming innovative medical ideas into viable business ventures, providing comprehensive support from project creation to operational development. It partners with prominent organizations in the industry, including Medtronic and Sofinnova Partners, to facilitate the growth of medical device start-ups. By employing both strategic and hands-on approaches, MD Start aims to guide these projects through the investment stage and into commercial development, helping to bring new medical technologies to market.

Mazor Robotics Ltd. is a medical device company specializing in the development, production, and marketing of surgical technologies for orthopedics and neurosurgery. Established in 2000 and headquartered in Caesarea, Israel, the company focuses on computer-assisted surgery, enabling high-precision and minimally invasive procedures. Its flagship products include the Mazor X and the Renaissance guidance systems, which significantly enhance the accuracy of spinal surgeries, leading to improved clinical outcomes. These systems are designed to support complex surgical procedures while providing a safer environment for patients and medical staff. With the majority of its revenue generated in the United States, Mazor Robotics continues to innovate in the field of spine surgery, raising the standard of care in surgical practices.

Responsive Orthopedics LLC is a Minneapolis-based company that designs and develops knee implant systems, with a focus on providing low-cost hip and knee replacements. Established in 2013, the company offers logistical support to physician practices and hospitals, catering specifically to healthcare providers involved in federal programs aimed at reducing the costs associated with hip and knee procedures. In June 2016, Responsive Orthopedics became a subsidiary of Medtronic plc, further bolstering its capabilities in the healthcare marketplace. The company’s commitment to affordability and support positions it as a significant player in the orthopedic implant sector.

Gynaecology has been rapidly built around Smith & Nephew's resection technologies and comprises, primarily, the TRUCLEAR◊ System for the hysteroscopic resection and removal of uterine tissue. Gynaecology delivered revenue of $56 million in 2015, representing a little over 1% of Group revenue.

Bellco S.r.l. is an Italian company that specializes in medical devices for renal care, focusing on the treatment of renal failure, multiple organ failure, sepsis, and congestive heart failure. Founded in 1972 and headquartered in Mirandola, Italy, the company offers a wide range of products, including haemodiafiltration therapies, dialysis machines, haemodialysers, blood lines, catheters, concentrates, and sorbent cartridges. Bellco also develops therapeutic systems for acute patients in intensive care, as well as for neonatal patients. The company's commitment to innovation and research enables it to address the evolving needs of patients and healthcare professionals in nephrology, intensive care, and cardiology. It markets its products directly in Italy and has a presence in various countries through branches and distributors, including France, Spain, Belgium, Brazil, China, and Canada. Bellco operates as a subsidiary of Medtronic plc.

Aircraft Medical Limited develops and produces hand held medical devices. It offers McGRATH, a portable video laryngoscope. The company specializes in anesthesia and critical care products. It markets its products through distribution partners in the United States, Canada, the United Kingdom, Ireland, Italy, France, Denmark, Sweden, Norway, Benelux, and Australasia. Aircraft Medical Limited was formerly known as Smartscope MD Ltd. and changed its name to Aircraft Medical Limited in February 2004. The company was founded in 2001 and is based in Edinburgh, the United Kingdom. As of November 18, 2015, Aircraft Medical Limited operates as a subsidiary of Medtronic plc.

SetPoint Medical Corporation is a clinical-stage bioelectronic medicine company based in Valencia, California, focused on developing implantable neuromodulation devices for treating chronic inflammatory diseases, including rheumatoid arthritis and Crohn's Disease. The company leverages the Inflammatory Reflex, a natural mechanism that allows the central nervous system to regulate the immune system, which has been extensively studied and documented in scientific literature. SetPoint's proprietary microregulator aims to enhance this reflex through vagus nerve stimulation, offering an alternative treatment option that provides systemic anti-inflammatory effects. The devices are designed to supplement the body's natural responses and are expected to deliver comparable anti-inflammatory potency to leading medications, while potentially offering improved safety and lower costs. Currently, SetPoint is conducting human trials for its technology at multiple centers in Europe.

Medtronic is a leading global company based in the United States, founded in 1949, that specializes in the development and manufacturing of medical technologies and therapies. The firm focuses on creating innovative solutions for chronic diseases and pain management, offering device-based treatments that aim to improve patient outcomes and enhance quality of life. Medtronic's extensive range of products and services addresses various health conditions, demonstrating its commitment to advancing healthcare technology. In addition to its core business, Medtronic also manages venture capital initiatives, such as the Suzhou Medtronic RMB Fund, which aims to invest in healthcare innovations in China. The company is dedicated to delivering lifelong solutions for individuals suffering from chronic health issues.

Twelve manufactures medical devices. It was formerly known as Foundry Newco XII, Inc. The company was incorporated in 2009 and is based in Menlo Park, California.

RF Surgical Systems, Inc. is the market leader in the detection and prevention of retained surgical sponges. The RF Surgical Detection System is the preferred solution in more than 1,500 operating rooms, trauma and labor and delivery suites nationwide. Since January 2011, more than 70 hospitals and surgical centers have joined the fast-growing list of care providers using RF Surgical Technology. RF Surgical Systems is based in Bellevue, Washington with R & D facilities in San Diego, California. The advanced technologies used in the RF Surgical Detection System are protected by U.S. patents. Regulatory clearance to market the system was granted by the U.S. Food and Drug Administration in November 2006.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

AEGEA Medical is pioneering the application of its Adaptive Vapor Ablation technology to deliver therapies that provide high quality patient outcomes to a wider range of patients. AEGEA’s FDA approved water vapor technology enables the delivery of a safe and effective endometrial ablation for the treatment of menorrhagia in a simple, office-based procedure that takes only minutes. With a vision to expand safe and effective treatment options to more patients, and provide physicians with the confidence and convenience necessary to perform office-based procedures, AEGEA is inspiring new approaches to women’s healthcare. Founded in 2008, AEGEA Medical is located in in Menlo Park, California.

Ortho Kinematics, Inc. is a healthcare diagnostics company based in Austin, Texas, specializing in spine imaging informatics. Established in 2006, it develops advanced diagnostic technology solutions for assessing spinal instability. The company offers the KineGraph Vertebral Motion Analyzer, an automated system that utilizes fluoroscopy to capture spine motion, generating patient-specific graphs that aid clinicians in diagnosing and treating back and neck pain. Additionally, Ortho Kinematics provides cloud-based analysis of instability testing results along with video X-ray imaging services through its imaging center. The company's innovations support spine clinicians by delivering critical insights into spinal health.

DreaMed Diabetes, Ltd. is an Israeli company founded in 2014 that specializes in developing innovative solutions for diabetes treatment and management. The company is known for its Glucositter, a closed-loop insulin delivery system designed to monitor glucose levels in real-time and adjust insulin delivery accordingly. DreaMed Diabetes has made significant advancements in the field, including the commercialization of the first artificial pancreas technology and becoming the first company to receive FDA clearance for a decision support system that integrates data from continuous glucose monitors and insulin pumps. Its Advisor Pro software, developed by diabetes professionals, utilizes artificial intelligence to enable healthcare providers to quickly analyze patient data and recommend optimal treatment plans. This technology facilitates frequent insulin titration adjustments and online monitoring, ultimately improving patient outcomes by lowering A1C levels and reducing complications. DreaMed Diabetes aims to provide patient-centered care, ensuring that all individuals with diabetes receive high-quality treatment regardless of their location or healthcare provider.

Diabeter B.V. is a diabetes clinic and research center located in Rotterdam, the Netherlands. The organization focuses on providing specialized care for individuals with diabetes, employing innovative approaches to treatment and management. Since April 2015, Diabeter has operated as a subsidiary of Medtronic, a global leader in medical technology. Through its clinical and research activities, Diabeter aims to improve diabetes care and outcomes for patients, contributing to advancements in diabetes management.

Advanced Uro-Solutions is a company that specializes in the development and manufacturing of medical devices aimed at treating various health conditions. One of its primary products is the NURO percutaneous tibial nerve stimulation system, which includes a small external stimulator and a reusable lead designed to provide temporary stimulation to the tibial nerve. This technology is particularly focused on addressing urinary urgency and incontinence, as well as bowel control disorders. Additionally, the company explores solutions for cardiac rhythm disorders and neurological conditions, contributing to a broader spectrum of healthcare needs.

Founded by Dr. Eugenio Cremascoli, the main business of NGC Medical Focuses are: Project planning, manufacturing and marketing of medical and surgical devices Import and distribution in national territory of medical devices, medical data management systems, medical communications database for remote access and medical equipment Design and turnkey implementation of Surgery Units, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories In-service management of Surgical Suites, Intensive Care, Hemodynamics, Electrophysiology and Intervention Radiology Laboratories Design and implementation of Information Management Software packages unifying the administrative and clinical departments within at single interface

Visualase, Inc., founded in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in developing laser and image-guided technologies specifically for thermal ablation applications. The company has created innovative tools designed for the treatment of cancer and other malignancies, utilizing advanced laser and MRI-based guidance systems to enhance precision and effectiveness in medical procedures.

Covidien plc is a global leader in the development, manufacture, and sale of healthcare products designed to enhance patient outcomes and reduce healthcare delivery costs. The company operates through four main segments: Medical Devices, Imaging Solutions, Pharmaceutical Products, and Medical Supplies. The Medical Devices segment includes a wide range of products such as endomechanical instruments, soft tissue repair solutions, energy devices, and monitoring products. Imaging Solutions focuses on radiopharmaceuticals and contrast agents, while the Pharmaceutical Products segment develops dosage pharmaceuticals and active ingredients. Additionally, the Medical Supplies segment encompasses nursing care products and surgical supplies. By collaborating with medical professionals, Covidien aims to improve the quality of life for patients and deliver effective healthcare solutions across clinical and home settings.

Corventis is committed to improving clinical outcomes and lowering healthcare costs by enabling the early detection of cardiovascular events while allowing patients to maintain an active lifestyle.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

TyRx engages in the design, development, and commercialization of resorbable polymeric biomaterials. It offers PIVIT CRM, a mesh based pouch, which contains antibacterial agents to help provide protection from microbial colonization of the generator or defibrillator during and immediately after surgical implant. The company also provides AIGISRx Flat, an antibacterial product that provides protection against infections associated with implanted pacemakers and defibrillators. TyRx Pharma, Inc. was formerly known as Advanced Materials Design, LLC. The company was founded in 1997 and is based in Monmouth Junction, New Jersey.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

Cardiocom specializes in telemedicine solutions focused on daily remote patient monitoring and disease management. The company provides health professionals with telehealth devices and services designed to identify symptomatic patients and facilitate early interventions, thereby reducing unnecessary hospitalizations. Cardiocom's offerings address a range of chronic conditions, including congestive heart failure, chronic obstructive pulmonary disease, asthma, diabetes, hypertension, and obesity. The product lineup includes the Cardiocom OMNIVISOR PRO Patient Management System, TELESCALE for heart failure management, and COMMANDER for patients with multiple chronic diseases. By implementing Cardiocom's proactive solutions, healthcare organizations can enhance patient quality of life while achieving cost savings in health management.

MC10, Inc. specializes in developing and selling wearable medical sensors that capture clinical-grade biometric and physiological data for use in clinical trials. Founded in 2008 and based in Lexington, Massachusetts, the company offers several innovative products, including BioStamp nPoint, which processes raw data into clinical metrics such as vital signs and sleep patterns; Kintinuum, a rehabilitation device for orthopedic surgery; WiSP, which provides cardiac monitoring and ECG recording; and BioStampMD, a flexible sensor designed to conform to the human body for comprehensive data collection. The BioStamp system enhances data acquisition by allowing for discreet and comfortable wear, thus facilitating targeted measurements of muscle activation and movement. MC10's dedication to creating flexible, conformal electronics aims to improve the quality of life by seamlessly integrating technology with human activity.

Mitralign is a privately held company based in a suburb of Boston, Massachusetts, focused on developing a catheter-based technology for the treatment of functional mitral regurgitation. The company has created an innovative system that mimics surgical annuloplasty by delivering surgical implants directly into the mitral annulus via a catheter. This process involves cinching the implants together to decrease the size of the mitral valve annulus and the valve opening. Mitralign's technology aims to provide a less invasive option for managing this life-threatening cardiac condition, enabling healthcare providers to effectively treat symptomatic functional mitral regurgitation through tissue-plication. The company is supported by prominent venture capitalists and has attracted investments from major cardiovascular device firms.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

Visualase, Inc., founded in 2005 as a spin-off from BioTex, Inc., is a privately held company based in Houston, Texas. It specializes in developing laser and image-guided technologies specifically for thermal ablation applications. The company has created innovative tools designed for the treatment of cancer and other malignancies, utilizing advanced laser and MRI-based guidance systems to enhance precision and effectiveness in medical procedures.

CardioInsight Technologies Inc. is a medical device company based in Cleveland, Ohio, specializing in non-invasive cardiac mapping systems. The company has developed a technology known as Electrocardiographic Mapping (ECM), which produces three-dimensional images of the heart's electrical activity. This innovative system integrates body surface electrical data with anatomical data from CT scans, allowing for real-time visualization of cardiac electrical activity. The process involves the use of a single-use, disposable multi-sensor vest that captures electrical signals from the body, which are then processed by software to create detailed epicardial 3D electroanatomic maps and virtual electrograms. CardioInsight's technology aims to enhance the accuracy of diagnosing and treating various heart conditions, particularly arrhythmias and congestive heart failure. The effectiveness of ECM has been validated through more than 260 patient studies. Since 2015, CardioInsight has operated as a subsidiary of Medtronic plc.

Functional Neuromodulation is a medical technology company that specializes in developing neuromodulation therapies aimed at treating Alzheimer's disease and other cognitive disorders. Established in 2010, the company is headquartered in Toronto, Canada, with an additional office in Minneapolis, Minnesota. Its primary offering is a deep brain stimulation (DBS) technology, which involves a surgically implanted device that delivers mild electrical pulses to specific areas of the brain. This approach is designed to enhance neural activity and modulate memory circuits, ultimately assisting patients in managing symptoms associated with memory and cognitive impairments. Through its innovative therapies, Functional Neuromodulation aims to improve the quality of life for individuals suffering from these challenging conditions.

PEAK Surgical is a medical device company based in Palo Alto, California, focused on developing surgical tools that combine the precision of a scalpel with the bleeding control typical of traditional electrosurgery. The company's flagship product, the PEAK Surgery System, includes a range of disposable cutting devices designed to minimize collateral damage during surgical procedures. This innovative system is approved for use in various surgical fields, including general, plastic and reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal, and neurological surgeries in the United States, as well as general surgery in the European Union. PEAK Surgical aims to fill a critical gap in the surgical market by providing enhanced tools for physicians.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

Spinal Modulation, Inc. provides medical devices research and development services. The company is based in Menlo Park, California. According to the 2002 Health Assessment on the Prevalence of Chronic Pain, severe chronic pain, as defined by the International Association for the Study of Pain, is prevalent in 10 to 13% of the adult population. Limited treatment options exist for these patients and the burden to the healthcare system is unsustainable. The Spinal Modulation AxiumTM Neurostimulator System is a next-generation intraspinal neuromodulation therapy that stimulates the dorsal root ganglion (DRG) to provide a new pain management option. It has shown promising results in managing chronic intractable leg pain, as well as difficult-to-target anatomies such as the back and foot. By stimulating the DRG, therapy can be adjusted to cover either broad or specific areas of pain throughout the torso and legs, while limiting uncomfortable postural effects typically experienced with other spinal cord stimulators.

PhysioSonics (Seattle, WA) a development-stage device company focused on ultrasound imaging to monitor blood flow in the brain.

Ardian is a privately held, clinical-stage medical device company that develops catheter-based therapies for hypertension treatment and related conditions. It develops a catheter system that uses radio-frequency energy to “deactivate” sympathetic nerves in the kidneys, lowering blood pressure. The company's flagship product, the Symplicity Catheter System, addresses uncontrolled hypertension through renal denervation, or ablation of the nerves lining the renal arteries. It has received the CE (Conformité Européene) mark and Australia's Therapeutic Goods Administration (TGA) listing but is not yet approved by the U.S. Food and Drug Administration (FDA).

Osteotech is focused on the development, manufacturing, and marketing of biologic, biomaterial, and device systems for musculoskeletal surgeries. It facilitates spinal, trauma, and total joint revision procedures. Osteotech was acquired by Medtronic in November 2010. It was founded in 1986 in Eatontown, New Jersey.

Axon Systems is the designer and manufacturer of various NIM Eclipse nerve monitoring systems, which have been marketed and sold in the United States by the Spinal and Biologics business at Medtronic for the past three years. These devices are used in surgery to enhance patient safety by protecting delicate nerves during implant procedures. Axon Systems has introduced an impressive number of "firsts" in the field of neuromonitoring, including: 16 and 32 channel simultaneous multimodality systems, integrated transcranial MEP, microscope and vital signs views, and integrated TCD and pulse oximetery.

CardioMEMS is a medical device company that has developed and is commercializing a proprietary wireless sensing and communication technology for the human body. Their technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure and aneurysms. Their miniature wireless sensors can be implanted using minimally invasive techniques and transmit cardiac output, blood pressure and heart rate data that are critical to the management of patients.

ATS Medical is a medical device manufacturer specializing in cardiovascular surgery products. ATS is a global company with product sales in more than 40 countries across the globe and superior product performance in more than 80,000 mechanical heart valves implanted to date. The ATS Open Pivot® Heart Valve utilizes a unique design specifically intended to offer advantages to the surgeon and improved quality of life to the patient. Instead of cavities in the hinge area, which is the case in all other bileaflet heart valves, The ATS Open Pivot® Heart Valve has open pivots. This enables the leaflets to pivot on smooth spheres that project gently into the bloodstream. The unique configuration eliminates cavities and stagnant areas where blood may collect and clot. For more information about The ATS Open Pivot® Heart Valve, please visit the expanded discussion for patients, physicians, or investors.

Atreo Medical develops novel medical tools to aid in resuscitation. Its first product is a CPR assist device used to enhance the quality of CPR both in and out of hospital.

Krauth Cardiovascular

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

MicroCHIPS Biotech, Inc. specializes in developing a microchip-based implant designed for drug delivery applications across various therapeutic areas, including osteoporosis, diabetes, multiple sclerosis, women’s contraception, and pain management. This innovative implant can store and release precise doses of medication over extended periods, offering an alternative to traditional therapies that rely on frequent injections. The implant is surgically placed under the skin during a minimally invasive procedure and can be wirelessly activated or deactivated by healthcare providers or patients. Additionally, the device allows for real-time adjustments to the drug dosage and frequency, catering to the specific needs of each patient. Established in 1999 and headquartered in Lexington, Massachusetts, MicroCHIPS operates as a subsidiary of Daré Bioscience, Inc.

GI Dynamics, Inc. is a medical device company that focuses on developing non-surgical therapies for the treatment of type 2 diabetes and obesity. The company's flagship product, EndoBarrier, is designed to help patients manage these conditions effectively. Founded in 2003, GI Dynamics is headquartered in Boston, Massachusetts, and markets its products primarily in Europe, the Middle East, the Asia Pacific, and South America. The company serves healthcare providers and third-party distributors, aiming to provide innovative solutions for metabolic diseases.

CardioMEMS is a medical device company that has developed and is commercializing a proprietary wireless sensing and communication technology for the human body. Their technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure and aneurysms. Their miniature wireless sensors can be implanted using minimally invasive techniques and transmit cardiac output, blood pressure and heart rate data that are critical to the management of patients.

Inspire Medical Systems, Inc., a medical technology company, focuses on the development and commercialization of minimally invasive solutions for patients with obstructive sleep apnea (OSA). It offers Inspire system, a neurostimulation technology that provides a safe and effective treatment for moderate to severe OSA. The company also develops a novel, a closed-loop solution that continuously monitors a patient’s breathing and delivers mild hypoglossal nerve stimulation to maintain an open airway. Inspire Medical Systems, Inc. was founded in 2007 and is headquartered in Golden Valley, Minnesota.

Ardian is a privately held, clinical-stage medical device company that develops catheter-based therapies for hypertension treatment and related conditions. It develops a catheter system that uses radio-frequency energy to “deactivate” sympathetic nerves in the kidneys, lowering blood pressure. The company's flagship product, the Symplicity Catheter System, addresses uncontrolled hypertension through renal denervation, or ablation of the nerves lining the renal arteries. It has received the CE (Conformité Européene) mark and Australia's Therapeutic Goods Administration (TGA) listing but is not yet approved by the U.S. Food and Drug Administration (FDA).

CryoCath Technologies specializes in the development, manufacture, and marketing of cryoablation catheter systems designed for the treatment of cardiac arrhythmias, tumors, and other bodily obstructions. The company’s product line features flexible, steerable catheters that utilize electromechanical consoles to deliver refrigerants through minimally invasive procedures. Key offerings include electrophysiology products such as the Achieve Mapping Catheter, Arctic Front, FlexCath, and the CryoConsole, along with various Freezor models. CryoCath distributes its innovative medical devices across Europe, North America, the Middle East, and the Russian Federation. As of now, CryoCath Technologies operates as a subsidiary of Medtronic, Inc.

Established in 1999, Restore Medical is a privately-held company focused on becoming the primary resource for physicians specializing in sleep and breathing disorders. Restore Medical has developed and markets proprietary implant technology which addresses such disorders as snoring and sleep apnea. The company's first product based on this technology, the patented Pillar™ System, received market clearance from the Food and Drug Administration in late 2002 and is currently available throughout the United States. Restore Medical also distributes other related high-quality products to the Ear, Nose and Throat physicians through our dedicated sales team. Located in St. Paul, Minnesota, Restore Medical manufactures the Pillar™ System in its onsite state-of-the-art Class 100,000 Clean Room. The company is ISO 9001 certified and utilizes an intranet-based quality and product development system. Restore currently employs a team of approximately 55 professionals.

NDI Medical LLC is a venture capital firm established in 2002, headquartered in Cleveland, Ohio, with additional offices in Chapel Hill, North Carolina, and Minneapolis, Minnesota. The firm specializes in seed and startup stage investments, focusing on innovative companies in the medical equipment and neurodevice sectors. NDI Medical aims to develop high-growth enterprises that create neurostimulation technologies and medical devices to address significant health conditions related to the brain and nervous system. Its team comprises experienced entrepreneurs, scientists, and professionals in various fields, including clinical and regulatory affairs, product development, quality assurance, and finance.

Mitralign is a privately held company based in a suburb of Boston, Massachusetts, focused on developing a catheter-based technology for the treatment of functional mitral regurgitation. The company has created an innovative system that mimics surgical annuloplasty by delivering surgical implants directly into the mitral annulus via a catheter. This process involves cinching the implants together to decrease the size of the mitral valve annulus and the valve opening. Mitralign's technology aims to provide a less invasive option for managing this life-threatening cardiac condition, enabling healthcare providers to effectively treat symptomatic functional mitral regurgitation through tissue-plication. The company is supported by prominent venture capitalists and has attracted investments from major cardiovascular device firms.

Founded in 1998, REVA Medical is dedicated to developing minimally invasive medical devices that leverage the Company's proprietary biomaterial and stent technologies to improve the treatment of disease. Guided by a management team and scientific advisors with extensive product development and clinical interventional cardiology experience, REVA's initial focus is the development of an innovative drug-eluting bioresorbable coronary stent and the commencement of clinical studies that will advance the treatment of coronary artery disease.

Kyphon is a medical device company based in Switzerland that specializes in developing minimally invasive technologies aimed at treating and restoring spinal anatomy. As a subsidiary of Medtronic, Inc., Kyphon focuses on creating surgical systems and apparatus designed for mixing materials and forming cavities, as well as other related products. The company’s offerings are particularly notable for their application in balloon kyphoplasty, a procedure used to treat spinal compression fractures that may result from conditions like osteoporosis or cancer. Through its innovative approach, Kyphon aims to restore and preserve spinal function while addressing the underlying causes of low back pain.

The O-arm® and StealthStation® systems eliminate the need to wear lead protective apparel during the navigated steps of the procedure. The O-arm offers multiple image protocols allowing you the flexibility to minimize dose to your patient based on your individual clinical objectives.

InnerPulse, Inc. develops technology, devices, software protocols, and procedures to transform the treatment of cardiac arrhythmias. It offers invasive treatment that enables physicians to implant the life-saving Percutaneous Implantable Cardioverter Defibrillator within the patient's vascular system. InnerPulse, Inc. was formerly known as Interventional Rhythm Management, Inc.

CardioMEMS is a medical device company that has developed and is commercializing a proprietary wireless sensing and communication technology for the human body. Their technology platform is designed to improve the management of severe chronic cardiovascular diseases such as heart failure and aneurysms. Their miniature wireless sensors can be implanted using minimally invasive techniques and transmit cardiac output, blood pressure and heart rate data that are critical to the management of patients.

Odin Medical Technologies develops, manufactures and commercializes Intraoperative MRI systems designed for use by the neurosurgeon in standard ORs. The compact, open PoleStar N-10* is a real-time imaging and navigation system utilized during all stages of brain surgery. The unit offers the neurosurgeon the differentiation capabilities of MRI without restricting the freedom of the surgical team to access the patient. The Company�s mission is to improve neurosurgical interventions with minimally invasive procedures. *PoleStar N-10 is FDA cleared for intraoperative MR imaging in a conventional O.R.

Medusa Medical Technologies Inc. specializes in developing electronic patient care reporting (ePCR) solutions aimed at enhancing pre-hospital emergency data capture and the effectiveness of medical staff. The company's flagship product, the Siren ePCR Suite, enables paramedics to document patient care seamlessly in real-time, facilitating efficient information sharing and workflow management. Key components of the suite include the Siren Field User for capturing patient data, the Siren Notification Board for real-time alerts to healthcare facilities, and Siren Data Analytics for in-depth data analysis. Additionally, the company offers professional services such as implementation support, custom development, cloud-based hosting, and training. Founded in 1996 and headquartered in Halifax, Canada, Medusa has expanded its presence with satellite offices in the United Kingdom and Malta, continuing to innovate in the field of emergency medical services documentation.

Vascular Architects, Inc. specializes in designing, developing, manufacturing, and marketing medical devices aimed at treating vascular stenoses, occlusions, and non-vascular obstructions. The company focuses particularly on peripheral vascular disease, which results from reduced or lost blood flow due to arterial narrowing or closure. Founded in October 1997 by Dr. Thomas J. Fogarty, a prominent surgeon and inventor, Vascular Architects has a strong management team with extensive expertise in technical, clinical, and business fields. The company also benefits from the insights of key opinion leaders in interventional and vascular surgery, who serve on its Scientific Advisory Board. In addition to vascular devices, the company produces various intraoperative vascular instruments and monitors used in multiple surgical specialties, including cardiovascular, urological, and neurological procedures.

Coalescent Surgical, Inc. develops advanced technology for blood vessel anastomoses. Its surgical's U-CLIP anastomotic device enables heart surgeons to create anastomoses without tying knots or managing sutures.

Percardia is a medical device company that develops therapies for the treatment of coronary artery disease. Its products include VSTENT myocardial implant, a balloon-deployable stainless steel stent. Percardia was founded in 1998 and is based in Merrimack, New Hampshire.

Medusa Medical Technologies Inc. specializes in developing electronic patient care reporting (ePCR) solutions aimed at enhancing pre-hospital emergency data capture and the effectiveness of medical staff. The company's flagship product, the Siren ePCR Suite, enables paramedics to document patient care seamlessly in real-time, facilitating efficient information sharing and workflow management. Key components of the suite include the Siren Field User for capturing patient data, the Siren Notification Board for real-time alerts to healthcare facilities, and Siren Data Analytics for in-depth data analysis. Additionally, the company offers professional services such as implementation support, custom development, cloud-based hosting, and training. Founded in 1996 and headquartered in Halifax, Canada, Medusa has expanded its presence with satellite offices in the United Kingdom and Malta, continuing to innovate in the field of emergency medical services documentation.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

Angiolink Corporation offers EVS vascular closure system, an arterial stapling device for use in closing holes and punctures made in arteries in connection with the catheter-based surgical procedures, such as angioplasty and angiograms.

The MindGuard team offers a unique blend of scientific and engineering expertise. The company know-how integrates the fields of mechanical engineering, blood flow dynamics and blood cell biology with cardiology, neurology and invasive radiology. World opinion leaders are active participants on the multidiscipline International Advisory Board purposed to further company endeavors.

Transvascular develops products for the treatment of coronary and peripheral vascular disease and congestive heart failure.

Odin Medical Technologies develops, manufactures and commercializes Intraoperative MRI systems designed for use by the neurosurgeon in standard ORs. The compact, open PoleStar N-10* is a real-time imaging and navigation system utilized during all stages of brain surgery. The unit offers the neurosurgeon the differentiation capabilities of MRI without restricting the freedom of the surgical team to access the patient. The Company�s mission is to improve neurosurgical interventions with minimally invasive procedures. *PoleStar N-10 is FDA cleared for intraoperative MR imaging in a conventional O.R.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

Endonetics is a developer of two novel endoscopic technologies, one diagnostic and one therapeutic, that will have a significant impact on the gastroenterologist's ability to manage patients with gastro esophageal reflux disease [GERD].

Paceart Optima System organizes and archives data for cardiac devices across multiple manufacturers and serves.

MiniMed, is currently developing an implantable insulin pump and a fully implanted long-term glucose sensor. In combination, these implantable products would create a closed-loop, ``artificial pancreas,'' allowing for more efficient regulation of blood glucose levels and a decrease in the frequency and severity of diabetic complications.

Salient Surgical Technologies, Inc., established in 1999, is a privately held medical technology company that specializes in advanced energy devices for surgical procedures. Initially focusing on monopolar electrosurgical devices for liver cancer treatment, the company has since developed the AQUAMANTYS® System, which features bipolar electrosurgical technology. This system is designed to minimize surgical blood loss through its patented TRANSCOLLATION® technology, which enables the haemostatic sealing of soft tissue and bone. The AQUAMANTYS System is utilized in various surgeries, including orthopaedic reconstruction, spine surgery, orthopaedic trauma, and surgical oncology. Salient's products are distributed in the United States, Europe, and Asia, benefiting hospitals, healthcare providers, and patients by enhancing clinical outcomes and reducing costs. To date, over 500,000 patients have undergone treatment using TRANSCOLLATION technology.

Xomed Surgical Products makes image-guided products to treat chronic sinusitis, which the company said affects more than 35 million Americans each year, as well as products to treat middle-ear infections, tonsil infections and sleep apnea. It has manufacturing facilities in Florida, Connecticut and France.

Physio-Control, Inc., maker of renowned LIFEPAKÂ:registered: defibrillators, has been developing technologies and designing devices that are legendary among first response professionals, clinical care providers and citizens everywhere. Their defibrillators set the standard upon which an entire industry was built. From the beginning, their product development was customer-driven.