MBX Capital

CND Life Sciences specializes in developing diagnostic tools for neurodegenerative diseases, particularly focusing on synucleinopathy. The company has introduced the Syn-One Test, which is designed to detect, visualize, and quantify abnormal phosphorylated alpha-synuclein in cutaneous nerve fibers. This commercially available test serves as an objective diagnostic aid for confirming synucleinopathy in patients suspected of having conditions such as Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy, or pure autonomic failure. By providing a convenient and minimally invasive method for diagnosis, CND Life Sciences enhances the ability of medical professionals to accurately identify these complex disorders.

AI-Enabled Coding for Medical Billing Teams

Tidal Vision Inc. is a manufacturer based in Ferndale, Washington, specializing in sustainable products derived from ocean waste, such as salmon skin and crab shells. Founded in 2015, the company focuses on producing chitosan, a biodegradable industrial biopolymer extracted from crab shells, using a zero-waste extraction process that ensures high quality and cost-effectiveness. Tidal Vision's product range includes Alaska Salmon leather goods, chitosan-based clarifying agents for beverages, water treatment solutions, antimicrobial polymers, and various eco-friendly plant foods and cleaning products. By leveraging proprietary technologies, Tidal Vision serves multiple industries, including textiles and agriculture, offering environmentally friendly alternatives that meet industry demands while promoting sustainability.

Vivodyne develops an automated robotic system that discovers life-changing drugs and cellular therapies. Its platform cultures the most realistic human tissues ever lab-grown to answer deep questions about human health.

Forum is a marketplace for peer support groups that connects mission-driven facilitators with people seeking support for life's biggest challenges–including life transitions, career, health, relationships, and more. Peer support is a proven model for personal change, healing, and growth – and our vision is a world where everyone has easy access to it.

Macro Trials develops a precision research clinical platform aimed at streamlining the process of bringing therapeutics to market. The company provides essential infrastructure to simplify distributed clinical trials, facilitating new site activation and site monitoring. By collaborating with pharmaceutical companies, physicians, and health systems, Macro Trials designs, plans, and executes clinical trials for high-value therapeutics, enhancing research velocity and enabling broader participant engagement. This approach not only improves the generalizability of research results but also generates valuable longitudinal patient records, contributing to the advancement of clinical research.

Thesis offers personalized brain supplements that cater to all types of brains. They create potent nutritional compounds to improve mental function and provide individualized suggestions depending on their customers' goals and brain chemistry.

Contraline, Inc. is a biotechnology company based in Charlottesville, Virginia, focused on developing male birth control solutions. The company is creating an innovative, long-lasting, non-hormonal, and reversible contraceptive known as Echo-V. This product consists of an ultrasound-visible polymer solution that is injected into the vas deferens, forming a polymer hydrogel device. This device acts as a semi-permeable membrane, effectively blocking sperm while allowing bodily fluids to pass through. Contraline also offers Vasintomy, a non-surgical procedure for the insertion of Echo-V, providing a cost-effective and user-friendly approach to male contraception. Founded in 2015, Contraline aims to transform male reproductive health through its groundbreaking technology.

Freedom Biosciences is a biotechnology platform focused on developing next-generation psychedelic therapeutics. The company aims to create innovative psychedelic pharmaceuticals by utilizing the established pharmacology of ketamine and other psychedelic compounds. This approach is intended to equip medical professionals with effective treatment options for patients suffering from resistant depression and various mental disorders.

Arine optimizes medications and improves human health through data-driven clinical services. Arine focuses on improved outcomes and lower cost of care for patients. They partner world class data scientists and engineers with expert clinicians to develop and deliver meaningful clinical service programs. They deliver the right intervention, for the right patient, at the right time. They guide patients as they progress through their journey. They focus on outcomes. Your success is their success. They take an evidence-based approach to patient health management to drive clinical results.

OFFOR Health is an on-site care delivery platform that enhances access to healthcare by utilizing existing medical and dental facilities. The organization aims to address surgery backlogs and improve outcomes for Medicaid patients through its innovative approach. OFFOR Health specializes in providing pediatric dental anesthesia and is expanding its services into various areas, including Mobile Integrated Healthcare, community paramedicine, primary care driven by dental services, and vaccinations. By connecting healthcare professionals with patients in local communities, OFFOR Health strives to deliver specialist anesthesiology care and essential supplies directly to those in need, ultimately increasing accessibility and reducing healthcare costs.

SmileMD is an on-site anesthesia service company bringing anesthesia care teams and logistics to optimize the venue for surgeries. It provides anesthesia to pediatric and adult dental practices in their office setting, reducing anxiety and increasing access to care for thousands of patients each year. They utilize the same safety processes and procedures as hospitals, and our anesthesia care team allows us to provide the highest quality patient care efficiently and safely.

Atlas Labs is a streamline patient enrollment in external programs to convert uncompensated care to revenue and reimbursements.Automate internal financial assistance for those that do not qualify. Help patients manage their out-of-pocket responsibility – all while improving margins, demonstrating higher levels of compliance, and meeting community needs.

Smiles.ai leverages proprietary technology and expert healthcare professionals to provide access to high-quality and cost-effective dental care products and services.

Freedom Biosciences is a biotechnology platform focused on developing next-generation psychedelic therapeutics. The company aims to create innovative psychedelic pharmaceuticals by utilizing the established pharmacology of ketamine and other psychedelic compounds. This approach is intended to equip medical professionals with effective treatment options for patients suffering from resistant depression and various mental disorders.

Contraline, Inc. is a biotechnology company based in Charlottesville, Virginia, focused on developing male birth control solutions. The company is creating an innovative, long-lasting, non-hormonal, and reversible contraceptive known as Echo-V. This product consists of an ultrasound-visible polymer solution that is injected into the vas deferens, forming a polymer hydrogel device. This device acts as a semi-permeable membrane, effectively blocking sperm while allowing bodily fluids to pass through. Contraline also offers Vasintomy, a non-surgical procedure for the insertion of Echo-V, providing a cost-effective and user-friendly approach to male contraception. Founded in 2015, Contraline aims to transform male reproductive health through its groundbreaking technology.

Mae is a women's health care center providing pregnancy and postpartum support, tailored to women's needs. Mae is establishing a world in which high-quality, proactive care is the norm. Mae improves the quality of care for Black women by providing a trusted, digital-first health platform.

Attivare Therapeutics focuses on the development of biomaterial-based vaccines aimed at enhancing immune responses against tumors that exhibit low immunogenicity. The company’s innovative approach involves creating a specialized microenvironment within the body that concentrates immune cells and delivers immunomodulatory agents to these cells. This strategy is designed to effectively reprogram the immune response, breaking tolerance to cancer antigens. By leveraging this technology, Attivare Therapeutics enables researchers to develop bioactive components that significantly improve the magnitude and durability of immune responses in patients.

CareRev is a healthcare staffing marketplace that connects medical facilities directly with per diem healthcare professionals, eliminating the need for vendors or agencies. Its online platform allows hospitals and outpatient facilities to efficiently fill shifts by accessing a pool of flexible clinical talent. This model not only expedites the staffing process but also helps facilities reduce costs and maintain appropriate nurse-to-patient ratios, ultimately enhancing the quality of patient care. By facilitating direct communication between healthcare providers and staff, CareRev empowers professionals to choose their work schedules and locations, promoting greater flexibility in the healthcare workforce. The company has received funding from notable investors, including Y Combinator and several prominent business angels.

Vital Bio is focused on transforming lab testing to make healthcare more accessible and personalized. The company develops advanced diagnostic technologies that connect diagnosis and treatment through a comprehensive ecosystem of devices, software, and services. By empowering patients to monitor their health and manage diseases, Vital Bio aims to enhance the overall healthcare experience. Their approach seeks to reduce disparities in healthcare outcomes and redistribute control to patients while equipping healthcare providers with the tools necessary to achieve better results.

ixlayer is a prominent player in the health-tech sector, specializing in virtual health testing solutions for health systems, payors, biopharma, and health-focused organizations. Founded in 2018, the company provides a comprehensive platform that addresses the technical, security, regulatory, and user experience aspects of complex health testing. As the healthcare landscape increasingly embraces remote care, ixlayer enhances patient engagement and supports preventative health strategies through scalable virtual testing options. The platform can be integrated into existing patient engagement systems and portals, facilitating real-time health and wellness lab testing. ixlayer currently serves millions of patients and has successfully launched numerous testing programs for major organizations, health systems, and government entities.

AmacaThera Inc. is a clinical-stage biotechnology company based in Toronto, Canada, established in 2016. The company focuses on developing and commercializing an injectable hydrogel technology designed to enhance drug delivery for various medical applications. This innovative platform aims to improve patient outcomes in areas such as post-surgical pain management, cancer treatment, and other challenging therapeutic targets. AmacaThera's technology features a fast-gelling material that transitions from a liquid to a gel under force, combining hyaluronan and methylcellulose. This unique formulation allows for localized and sustained drug delivery, ultimately assisting healthcare providers in effectively managing patients' pain following surgery.

Concert Health, Inc. is a company that develops and operates an online platform designed to connect physicians with therapists and psychiatrists, facilitating the integration of behavioral health services into primary care practices. Founded in 2016 and headquartered in San Diego, California, the company provides a range of services including remote clinical staffing with behavioral care managers and psychiatric consultants, as well as tools for registry, screening, workflow management, and reimbursement. Concert Health emphasizes evidence-based care by assisting medical groups in implementing shared care plans that address both physical and mental health needs. By working closely with primary care teams, Concert Health aims to enhance the quality of behavioral health care through effective documentation and billing support, ultimately improving patient outcomes.

Earli is a company focused on developing innovative cancer treatment devices that utilize synthetic biomarkers for early cancer detection. The company's approach involves a novel gene therapy technique known as Synthetic Biopsy, which prompts cancer cells to produce synthetic, non-human biomarkers. These biomarkers can be detected through various means, including blood, urine, or breath, allowing for timely tracking and treatment of cancer. By facilitating the early identification of cancer when it is still homogeneous, Earli aims to significantly enhance survival rates. Their technology not only aids in detection but is also applicable for therapeutic interventions, thereby personalizing treatment and improving patient outcomes.

SecureAire is a developer of advanced active particle control technology aimed at enhancing air filtration efficiency. This innovative technology effectively removes small, critical particles, including bacteria, viruses, allergens, volatile organic compounds (VOCs), gases, and odors from indoor environments. By significantly reducing or eliminating these harmful particles, SecureAire's solutions help hospitals, commercial buildings, and residential spaces improve air quality, mitigate the risks associated with sick building syndrome, and curb the spread of dangerous airborne pathogens.

Koneksa Health Inc. is a healthcare data analytics company focused on enhancing clinical studies and disease research through the use of remotely generated patient data. The company's software, Koneksa Compare, facilitates the collection, visualization, and analysis of patient-generated data, incorporating emerging technologies such as bio-sensors, activity trackers, and mobile-based questionnaires. This platform allows pharmaceutical and biotech companies, as well as academic researchers, to make informed decisions and regulatory claims based on objective data. Koneksa also provides biometric devices that generate electronic clinical outcome assessments and offers a dashboard for monitoring patient engagement, which includes reminders for study subjects. Founded in 2013 and headquartered in New York, Koneksa has an additional office in London, United Kingdom.

Atlas Labs is a streamline patient enrollment in external programs to convert uncompensated care to revenue and reimbursements.Automate internal financial assistance for those that do not qualify. Help patients manage their out-of-pocket responsibility – all while improving margins, demonstrating higher levels of compliance, and meeting community needs.

Brightside is a financial health company that offers an employer-based platform focused on improving the financial well-being of workers, particularly those living paycheck to paycheck. The platform addresses challenges faced by front-line workers, such as high turnover, healthcare costs, and productivity issues. Brightside provides tailored financial solutions supported by technology-driven financial assistants and a comprehensive app. This approach personalizes services to meet the individual needs of employees and their families, promoting better financial decision-making through behavioral science. By streamlining access to curated financial products, Brightside aims to enhance employee productivity and retention while contributing to a more diverse and equitable workplace.

Wellth is a digital health company based in New York that aims to enhance treatment adherence among individuals with chronic conditions. By leveraging behavioral economics, Wellth addresses the barriers that hinder patients from forming healthy habits and effectively managing their diseases. The company operates a mobile application that provides targeted incentive plans, reminders, and information to motivate users to engage in preventive health behaviors. Its platform not only empowers consumers to improve their adherence to medication and care plans but also helps reduce preventable hospitalizations and healthcare costs. Wellth's approach includes proven outcomes demonstrated through randomized controlled trials, making it a valuable solution for insurers and healthcare providers seeking to improve population health. Through its user-friendly application, Wellth supports members in establishing sustainable healthy habits while generating cost savings for payors.

Lucy Goods, Inc. is a manufacturer and seller of nicotine gum and lozenges, providing alternatives to traditional tobacco products. Founded in 2016 and headquartered in Los Angeles, California, the company focuses on reducing tobacco-related harm by offering next-generation nicotine products made with pure nicotine and food-grade ingredients. Lucy Goods provides its offerings in various flavors, including fruit, mint, and cinnamon, and sells its products primarily through online channels. The company aims to deliver a cleaner and more convenient alternative to existing nicotine products on the market.

CloudCath is offering a sensor enabled digital platform for peritoneal dialysis patients that provides early complication detection and safely reduces the number of monthly patient visits.

Physical therapy is powerful—for developing strength, managing emerging conditions, or recovering from surgery. But it’s challenging for physical therapy to make a significant clinical impact because therapists and patients are worn out. Traditional physical therapy leaves more than 50% of therapists suffering from work-related pain and 70% of patients failing to complete their course of care. On both sides of the therapy table, people need better support. At Luna, they’re designing a practice that gives therapists and patients the independence, control, and motivation they need to feel meaningful relief.

Uniform Teeth is an orthodontics practice committed to making orthodontic care as intuitive, accessible, and high quality as possible. Uniform Teeth specializes in providing clear straighteners.

Meissa Vaccines is a start-up pharmaceutical development company focused on the in-licensing and advancement of vaccines for respiratory syncytial virus (RSV, the largest unmet respiratory medical need in pediatrics) and rhinovirus (leading cause of infectious disease worldwide). Their passion is child health, but our vaccine programs have the potential to benefit multiple age groups directly and indirectly. Successful vaccines for respiratory syncytial virus and rhinovirus would have widespread benefits for society and families. These include reducing the burden of acute lower respiratory tract disease, reducing colds, reducing acute asthma exacerbations caused by these viruses, and alleviating missed school and work.

Buoy provides a personalized all-in-one platform to help guide consumers back to health. Whether it's chatting about symptoms with Buoy Assistant to get help in the moment of sickness or researching benefits through Buoy Dashboard, Buoy is available 24/7 to help make self-diagnosis and navigating the healthcare system simple and easy. For employers, Buoy can be custom configured to surface benefits information and wellness programs, guide employees to in-network providers, and fully integrate with other health portals. The company was founded in 2014 and is headquartered in Boston, Massachusetts.

Osmosis is a personalized learning platform that helps you retain more, gain a deeper understanding of concepts & feel more prepared for your courses & exams. Osmosis empowers the clinicians and caregivers with the best learning experience.

Mightier is a gaming platform and family program scientifically-proven to help kids regulate their emotions. It is a bioresponsive program that harnesses the mind-body connection to build emotional regulation in its players. Its program of bioresponsive video games, developed at Boston Children's Hospital and Harvard Medical School, aims to help children with behavioral and emotional challenges learn how to harness emotions in daily life. Mightier was founded in 2016 and is headquartered in Boston, Massachusetts.

SPARK Neuro Inc. is a neuroscience company based in New York, founded in 2013. It specializes in market research for the advertising and entertainment industries, utilizing neuroscience tools to enhance audience engagement and storytelling. Additionally, SPARK Neuro focuses on analyzing brain activity to improve clinical care and therapeutic discovery. The company partners with prestigious institutions to develop its patented neural metrics and advanced machine learning algorithms, exemplified by the SPARK Scan, a 10-minute EEG-based evaluation that helps identify early signs of changes in brain health. Through its innovative platform, SPARK Neuro aims to make brain health measurement universally accessible, enabling healthcare professionals to better understand and address neurological and psychiatric conditions.

Opentrons is a company that specializes in the development of automated laboratory equipment, particularly pipetting robots designed to streamline and enhance the efficiency of scientific experiments. By utilizing open-source technology and the Python programming language, Opentrons enables researchers to automate various laboratory processes, thereby reducing the potential for human error and expediting experimental workflows. Their product offerings include lab robots, workstations, hardware modules, consumables, reagents, and labware, all aimed at facilitating a more efficient and accurate research environment.

Sonavex, Inc. is a Baltimore-based company founded in 2013 that specializes in advanced imaging technology aimed at enhancing surgical outcomes. The company has developed a proprietary ultrasound-based platform that enables clinicians to detect anastomotic blood clots and assess critical intravascular flow metrics directly at the point of care. This technology not only facilitates the measurement of blood flow and vessel morphology but also includes bioresorbable and echogenic equipment to mark at-risk blood vessels for future assessments. By providing actionable data, Sonavex supports healthcare providers in monitoring and improving patient care, particularly in the context of post-operative complications.

SwiftShift Ltd. is a London-based company founded in 2012 that specializes in real-time workforce management solutions for the healthcare sector, specifically focusing on pediatric home care. The company addresses the increasing demand for pediatric home care, which is often more effective and economical than institutional care. SwiftShift offers a unique, nurse-managed delivery service that empowers nurses by replacing traditional office-based case managers with self-managed care teams. These teams have the autonomy to select their patients and control their schedules, fostering a greater sense of ownership in care management. Utilizing an AI-based home care management platform, SwiftShift enhances the efficiency of care delivery by providing nurses with easy access to relevant data, enabling better decision-making for patient well-being. The company is dedicated to improving patient outcomes through exceptional nursing experiences, offering continuous training and support to its nursing staff, thereby ensuring they are well-equipped to provide high-quality care.

EpiBone, Inc. is a biotechnology company based in Brooklyn, New York, focused on developing advanced solutions for bone and cartilage repair. Founded in 2013, EpiBone utilizes patient-specific scans and their own stem cells to create customized bone grafts, which are cultivated in a bioreactor to facilitate growth. The company aims to improve skeletal repair and enhance bone formation and regeneration through its innovative technologies. EpiBone's lead product, a living 3D bone graft, successfully completed its Phase I/IIa clinical trial in August 2023. Additionally, the company is advancing its cartilage repair pipeline, which includes an allogeneic osteochondral plug that received Investigational New Drug approval in July 2023, and an injectable cartilage filler, partly funded by the Department of Defense. Through these developments, EpiBone seeks to revolutionize orthopedic repair and provide patients with more effective treatment options.

Perceptive Navigation LLC is a pre-clinical stage medical device company based in Baltimore, Maryland, focused on developing interventional medical devices for image-guided surgery. Its flagship product, Vu-Path, is an innovative intracorporeal ultrasound device that combines forward-viewing ultrasound imaging with a working portal for the introduction of needles, biopsy instruments, guide wires, and therapeutic delivery. Designed to enhance the safety and efficacy of minimally invasive procedures across various medical specialties, including radiology, cardiology, interventional oncology, and urology, Vu-Path addresses critical limitations of existing imaging techniques, which can be costly, cumbersome, and risky. The device aims to provide accurate and precise access to internal structures, thereby reducing procedural times and enhancing overall patient care. By replacing traditional imaging methods like surface ultrasound, CT, X-Ray, and MRI, Vu-Path is positioned to streamline complex surgical operations while minimizing resource requirements. Perceptive Navigation was incorporated in 2012 and continues to advance its technology to meet the needs of the medical community.

MHB Labs is a virtual biotech founded by two leading physician-scientists at Men's Health Boston. Our goal is to leverage clinical insight and industry partnerships to develop new, high-impact products within our field. We have assembled a global team of world-class advisors, contractors, and strategic partners that will allow us to build value around early phase clinical ideas and position them for market success.

Persist assist pharmaceutical companies in developing long-acting formulations 50% faster. Because the formulation development process is manual and relies on scientific intuition, it takes a pharmaceutical company 5-10 years to develop a long acting formulation for a drug. This effort is divided into five years of pre-clinical development and five years of clinical testing. Their goal is to use machine learning and automation to reduce the time required for pre-clinical formulation development to three months, making the formulation development process 50% faster.