Innovation Works

Advanced Optronics specializes in the design and manufacture of implantable sensors aimed at enhancing intraoperative monitoring during surgeries. These innovative sensors provide real-time feedback to surgeons, helping to minimize trauma and prevent damage to residual hearing during implant procedures. The company focuses on developing flexible and biocompatible sensor systems that facilitate less invasive surgical techniques across various medical applications. By integrating flexible micro-electromechanical system sensors with cochlear implants, Advanced Optronics aims to improve surgical outcomes and support surgeons in performing procedures with greater precision and care.

Parcel Health is dedicated to revolutionizing medication packaging by offering the world's first fully brandable and compostable paper-based prescription bottle. This innovative product aims to replace traditional plastic bottles, contributing to sustainability efforts and helping pharmacies and pharmaceutical companies achieve carbon neutrality goals. Parcel Health's packaging not only enhances the safety and integrity of medications during shipping but also improves logistical efficiency, minimizing in-transit damage and bolstering customer satisfaction. Designed to be child-resistant and elder-friendly, the company’s solutions improve pharmacy workflows and reduce medication errors, positioning Parcel Health as a leader in eco-friendly pharmaceutical packaging.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Revitalize Energy is a consumer-focused company that specializes in eye drops aimed at alleviating fatigue caused by prolonged screen use. The product features a patented blend of stimulants and amino acids that provides immediate energy and relief from digital eye strain. With just 1-2 drops in each eye, users experience a refreshing effect that helps combat tiredness and enhances comfort, making it an ideal solution for those frequently engaged with digital devices.

Hummingbird Systems provides On demand aerial mapping and data analysis of construction sites and agriculture using drones.

CapSen Robotics, Inc., founded in 2016 and based in Pittsburgh, Pennsylvania, specializes in advanced 3D computer vision systems that allow computers to interpret and navigate cluttered environments. The company offers a range of solutions, including cluttered object detection, scanning for both large and small objects, and object tracking, catering to diverse applications in factory automation, vehicle scanning, and retail inventory management. Drawing on research from MIT, CapSen’s technology enhances the capabilities of robots and computer vision systems, which are increasingly being utilized in less structured settings such as warehouses, hospitals, and homes. The company is currently beta testing its software with various system integrators and robotics firms, focusing on robotic picking applications and partnering with a major government contractor for a warehouse project. Their innovative object detection software has already demonstrated its effectiveness in competitive environments, such as a recent robotic order fulfillment competition.

BlastPoint specializes in big data solutions that enable companies to enhance revenue growth by effectively discovering, targeting, and engaging with their customer data. The company offers a predictive AI-powered platform that addresses customer engagement challenges, allowing businesses to find and satisfy their customers throughout their lifetime. BlastPoint serves a diverse range of sectors, including energy, finance, automotive, and nonprofit organizations, helping them identify trends and extract valuable insights specific to their territories or market dynamics.

FoodSocial operates a digital recipe creator and cooking platform focused on healthy cooking. The platform enables users to discover, meal plan, and shop for their favorite recipes, facilitating an interactive experience for both individual creators and brands. By allowing these entities to share their recipes and food-related content, FoodSocial inspires users to engage with and support a community centered around healthy eating.

Peoples Energy Analytics specializes in providing a comprehensive data-driven platform aimed at assisting utility companies in managing at-risk customers before they default on their energy bills. The company’s solution identifies individuals who may be at risk of non-payment and connects them with bill assistance resources well in advance of any missed payments. By offering a complete service that encompasses strategy design, data analysis, and marketing outreach support, Peoples Energy Analytics enables utility providers to reduce the incidence of unpaid energy bills while enhancing their revenue recovery efforts. The scalable and cost-effective approach modernizes how organizations engage with their customers, ultimately improving customer satisfaction and financial performance.

Ocugenix is a therapeutics company dedicated to developing cancer immunotherapy drugs specifically aimed at treating ocular diseases. The company focuses on creating small molecule immunotherapy drugs that target drug-resistant bacteria, which helps in managing complications such as fibrosis and angiogenesis. By addressing these issues, Ocugenix enables healthcare professionals to perform effective cancer-related treatments for eye conditions.

Plexision develops cellular biomarkers for personalized diagnosis and drug development in solid organ transplantation, and immunological disorders. Plexision's first patented product, the PleximmuneTM assay, predicts the risk of transplant rejection. The test is based on patent-pending technology to measure antigen-specific white blood cells. Testing services for transplant recipients and drug developers are provided at Plexision’s CLIA-certified, central laboratory in Pittsburgh. Plexision currently offers cell-based testing for personalized assessment of rejection risk after solid organ transplantation The Pleximmune blood test is the first such test offered for children with liver or intestine transplantation.

Honeycomb Credit, Inc. operates a peer-to-peer lending platform that connects small business owners with individual investors seeking to fund those businesses. Founded in 2017 and based in Pittsburgh, Pennsylvania, the company allows businesses to secure loans from their own customers and community members, facilitating debt crowdfunding. This innovative approach enables small businesses to obtain necessary capital without relinquishing equity, thus supporting their growth while providing a unique investment opportunity for lenders. By bridging the gap between traditional funding sources and community support, Honeycomb Credit enhances access to financial resources for small enterprises.

Belong For Me is a SAAS firm offering personalized approach to employee through their product CoExperiences.

SignatureDx is a biotechnology company that develops and operates a bioanalytical platform. This platform is designed to detect and monitor complex human diseases in their early, silent stages. The company focuses on non-invasive diagnostic testing, aiming to predict and treat diseases before they cause significant organ damage. By specializing in novel methods, SignatureDx enables individuals to receive timely and successful treatment, thereby improving health outcomes.

Toyz Electronics is a Pennsylvania-based company that specializes in technology-driven solutions for the education sector. The firm has developed a gamified learning platform aimed at empowering students to acquire STEAM (science, technology, engineering, art, and math) skills, alongside entrepreneurship and storytelling. By integrating hip-hop culture, music, gaming, and design elements, Toyz Electronics offers a project-based curriculum that is both culturally relevant and responsive. This innovative approach allows students to create their own superhero avatars and narratives while learning a diverse range of technical and soft skills, effectively transforming their ideas into reality.

PittMoss LLC specializes in the production of sustainable gardening products, primarily offering PittMoss, a peat-free potting mix made from organic additives and recycled paper fibers. Founded in 1994 and based in Ambridge, Pennsylvania, the company serves greenhouse and nursery growers as well as home gardeners across the United States. PittMoss is designed to provide an environmentally friendly alternative to traditional sphagnum peat moss, utilizing materials that would otherwise contribute to landfill waste. In addition to its primary product, PittMoss also offers PittMoss Prime, a versatile soil amendment that can be blended with compost, existing soil mixes, or native soil. Through its innovative approach to gardening solutions, PittMoss aims to make sustainable gardening more accessible and affordable for all users.

CleverApply is an educational administration platform established in 2020 and headquartered in Ohio, United States. The platform utilizes artificial intelligence and blockchain technology to assist students in identifying suitable universities based on their desired programs and needs. It facilitates connections between students, universities, and agents, allowing users to review necessary documents and prepare for interviews effectively. By streamlining the university selection process, CleverApply aims to enhance the overall experience for students seeking higher education opportunities.

PredxBio is a computational pathology company focused on developing artificial intelligence tools for analyzing whole slide image pathology samples through spatial analytics. The company's platform utilizes AI and machine learning to identify patterns and relationships within biological data, aiding clinicians and researchers in accelerating drug discovery and optimizing clinical trials. By automatically recognizing and classifying regions of interest in H&E-stained and immunohistochemistry slides, PredxBio enhances the decision-making process for pathologists and biopharma companies. This technology supports personalized therapeutic options, advances companion diagnostics, and improves clinical workflows, ultimately contributing to more efficient and targeted healthcare solutions.

BioHybrid Solutions is a biotechnology company focused on the development of innovative nanoarmored protein-polymer conjugates. The company specializes in tailoring the activity and stability of proteins and enzymes for various applications, primarily through research and development efforts. Utilizing atom transfer radical polymerization chemistry, BioHybrid Solutions grows polymers with precision from the surface of proteins. This approach enables advancements in therapeutics and protein engineering, providing physicians with effective alternatives in their medical practices. The company's work bridges the fields of proteins and polymers, emphasizing direct product sales alongside its R&D initiatives.

Exchangelodge LLC specializes in business process automation and data integration for private capital firms. Founded in 2015 and located in Pittsburgh, Pennsylvania, the company offers a platform that simplifies private capital data management and enhances team productivity. By providing a comprehensive playbook of critical workflows, enterprise data connectors, and high-quality reports, Exchangelodge enables clients to design and manage reporting from various source systems. The platform also allows users to record tasks, assign responsibilities, and monitor progress, thereby improving efficiency and mitigating data risks. With a focus on FinTech and RegTech, Exchangelodge streamlines data connectivity and automates manual processes, ensuring data accuracy and completeness to support informed decision-making in the private markets industry.

Phlux Technologies, Inc. is a developer of advanced 3D sensor technology aimed at enhancing safety and efficiency in robotics and automation. Founded in 2020 and headquartered in Pittsburgh, Pennsylvania, the company focuses on creating programmable 3D sensors that enable robots to navigate safely and collaboratively in industrial environments. By replacing traditional physical barriers with digital safety zones, Phlux's innovative products utilize proprietary optical sensing technology, artificial intelligence, and computer vision. These sensors help protect workers from hazardous machinery and alert vehicles to obstacles, ultimately freeing up floor space, reducing setup times, and improving overall productivity. Phlux Technologies is dedicated to enabling the development of smarter robots and self-driving vehicles, contributing to safer industrial operations.

Finish Robotics is focused on developing mobile robotics technology aimed at alleviating the labor shortage in the construction industry. The company specializes in creating semi-autonomous, collaborative robots that utilize standard industrial components. By leveraging this innovative technology, Finish Robotics enables contractors to effectively address the challenges faced by laborers on job sites, enhancing productivity and operational efficiency.

AdSkate operates an advertising technology platform that leverages machine learning and artificial intelligence to enhance the ad buying and selling process. By providing multiple data points, AdSkate offers deeper insights and intelligence into digital content, which aids brands in effectively advertising themselves. The company's services encompass campaign planning, direct buy analysis, programmatic and custom integration, as well as content discovery and analysis. This comprehensive approach enables brands to make informed decisions when purchasing ad spaces, ultimately leading to more effective advertising strategies.

UpContent, LLC is a technology company based in Pittsburgh, Pennsylvania, that specializes in content discovery solutions. Founded in 2015, it offers a software-as-a-service (SaaS) platform designed to enhance digital content curation for brands and improve audience engagement. The platform automates the process of discovering relevant news and blog articles, integrating with tools like Hootsuite and Buffer. Its features include the UpContent Gallery, which enables users to curate content, develop custom calls-to-action, and implement retargeting strategies to capture audience traffic. UpContent aims to simplify the search for quality content, empowering marketing, sales, and human resource teams to effectively share insights and foster meaningful conversations within their communities.

Shelfmark is an intelligence platform that specializes in remote inventory management, providing valuable insights for suppliers and eCommerce partners. The platform is designed to optimize product inventory by offering access to extensive product data, which supports all retail inventory needs. Through its tools, Shelfmark enhances inventory management processes, facilitating everything from forecasting to replenishment. This comprehensive approach enables businesses to make informed decisions, improve efficiency, and better manage their inventory.

Peoples Energy Analytics specializes in providing a comprehensive data-driven platform aimed at assisting utility companies in managing at-risk customers before they default on their energy bills. The company’s solution identifies individuals who may be at risk of non-payment and connects them with bill assistance resources well in advance of any missed payments. By offering a complete service that encompasses strategy design, data analysis, and marketing outreach support, Peoples Energy Analytics enables utility providers to reduce the incidence of unpaid energy bills while enhancing their revenue recovery efforts. The scalable and cost-effective approach modernizes how organizations engage with their customers, ultimately improving customer satisfaction and financial performance.

Adrich, Inc. is a company based in Pittsburgh, Pennsylvania, that specializes in electronic packaging hardware and customized software. Founded in 2016, Adrich provides a consumer insights platform that connects brands and retailers through detailed product usage data and analytics. The company's innovative smart packaging hardware, combined with its tailored software, facilitates autonomous data collection and transmission via product labels. This smart tracking system captures real-time information on usage patterns, including day, time, geolocation, and volumetric data, allowing brands and retailers to better understand consumer trends and behaviors. In doing so, Adrich aims to enhance customer engagement and retention strategies.

InceptEV is a technology company specializing in electric vehicle (EV) data solutions for fleet operations. It leverages proprietary data and patented technology to simulate and optimize fleet performance, enabling businesses to make informed decisions about EV adoption and plan for their operational needs.

Realyze Intelligence specializes in AI and machine learning-based clinical data analysis software that enhances the understanding of patient information. The company's platform utilizes natural language processing to interpret detailed clinical notes and structured data from electronic medical records. By capturing narrative data, it creates comprehensive patient case studies that enable clinicians to accurately identify specific patient populations affected by chronic diseases and cancer. This capability allows healthcare providers to ensure timely and effective treatment for patients with serious conditions.

Push2Spin Technologies is engaged in the development and commercialization of innovative solutions in plastic and podiatric surgeries. The company is focused on transforming the global soft tissue grafting market through its novel approach to small-volume fat tissue harvesting, processing, and transfer. By introducing disruptive technologies, Push2Spin aims to enhance clinical efficiency, streamline procedural workflows, and reduce associated time and costs for healthcare providers.

Aquatonomy provides underwater robot autonomy software that includes localization, mapping, and planning.

Mamalux is an online retailer specializing in innovative, leakproof apparel designed for maternity and breastfeeding. The company offers a range of personal luxury items, including gowns for nursing women, handbags made from authentic materials, and comfort-focused sleepwear for postpartum mothers. By providing a variety of stylish and functional options, Mamalux aims to enhance the shopping experience for new mothers, allowing them to prioritize self-care while maintaining their look.

Ariel Precision Medicine is an integrated genomics and digital health company based in Pittsburgh, Pennsylvania, that focuses on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases. Founded in 2013, the company develops innovative clinical decision support tools designed to simplify personalized treatment, particularly through its flagship product, ArielDx. This cloud-based platform specifically aids in the diagnosis and management of pancreatic disease, enhancing the capabilities of healthcare providers in both emergency and clinical settings. Ariel Precision Medicine aims to improve patient outcomes by leveraging advanced technology and genomic insights in healthcare.

Velo AI specializes in enhancing cyclist safety through its innovative product, Copilot, an AI-powered bike light and camera system. This technology integrates artificial intelligence with rear-facing video recording to improve visibility and awareness for cyclists. Copilot provides real-time alerts for approaching vehicles, capturing video recordings of each ride to document cyclist experiences and behaviors. Additionally, it features audible warnings to alert cyclists of potential dangers from behind and visual warnings to inform drivers of their proximity to bicyclists. The system's predictive risk estimation capabilities track driver behavior, promoting safer riding practices and helping to prevent accidents on the road.

Leaficient is a technology company specializing in Controlled Environment Agriculture (CEA). It develops and deploys energy-saving solutions, including low-cost cameras and sensors, to monitor plant growth and biometrics. This data enables clients to optimize energy usage, enhance crop yield and quality, and achieve predictable growth results.

Forest Devices, Inc. is a medical device company based in Pittsburgh, Pennsylvania, with an additional office in Canada. Founded in 2014, the company focuses on developing innovative solutions for stroke detection. Its primary product, AlphaStroke, is a portable and non-invasive stroke screening device that assists medical personnel in identifying early signs of both ischemic and hemorrhagic strokes. This device is designed to be low-cost and durable, enabling pre-hospital providers to triage patients effectively and make timely decisions regarding their care. By improving the speed and accuracy of stroke detection, Forest Devices aims to reduce delays in critical treatment for patients experiencing strokes.

Make it Home Safe is a mobile application designed to enhance safety and security during traffic stops for both motorists and law enforcement. Founded in 2017 and headquartered in Pittsburgh, Pennsylvania, the app facilitates real-time identification of motorists, aiming to reduce tensions and foster positive interactions between the public and police. By providing essential safety features, Make it Home Safe seeks to create a more secure environment on the road, ultimately promoting a sense of safety for all users involved in traffic encounters.

Kloopify is a platform focused on helping businesses reduce emissions associated with their purchased goods and services. It offers tools to track, manage, and report the carbon footprint of supply chains, providing a comprehensive view of environmental impacts across various categories. By facilitating more sustainable procurement decisions, Kloopify aids organizations in achieving their sustainability objectives while also enhancing revenue growth and minimizing risks related to environmental compliance. The platform is designed to support businesses in their transition toward more responsible purchasing practices.

Duo Oncology is focused on developing innovative nanoparticle technology designed to effectively penetrate established tumors, particularly in challenging cases such as pancreatic and bile duct cancers. The company aims to transform treatment outcomes through a novel monotherapy that enhances patient care for those with hard-to-treat tumors and relapsed metastatic disease. By collaborating with leading university scientists and medical oncologists, Duo Oncology leverages a network of established research organizations to expedite the development of its products. The technology addresses significant needs in immunotherapy and precision medicine, ultimately striving to improve recovery times and patient outcomes.

Webvizio is a visual feedback collaboration platform designed to enhance communication for web development projects. It facilitates real-time collaboration on live web pages and applications, allowing users to provide visual feedback directly on web elements. By streamlining the development process, Webvizio minimizes the need for extensive back-and-forth communication through various channels, such as email and video calls. The platform supports multiple projects simultaneously, allowing teams to assign tasks, set deadlines, and track progress efficiently. Additionally, it integrates with productivity tools, enabling web builders and team managers to significantly boost their productivity while collaborating effectively with both internal teams and external clients.

Toyz Electronics is a Pennsylvania-based company that specializes in technology-driven solutions for the education sector. The firm has developed a gamified learning platform aimed at empowering students to acquire STEAM (science, technology, engineering, art, and math) skills, alongside entrepreneurship and storytelling. By integrating hip-hop culture, music, gaming, and design elements, Toyz Electronics offers a project-based curriculum that is both culturally relevant and responsive. This innovative approach allows students to create their own superhero avatars and narratives while learning a diverse range of technical and soft skills, effectively transforming their ideas into reality.

Setex Technologies, a spin-out from Carnegie Mellon University, is a manufacturer of dry adhesive technology based in Pittsburgh, Pennsylvania. Established in 2009, the company specializes in micro-fibrillar polymer gripping surfaces and dry adhesives designed to address complex and costly manufacturing challenges. Its innovative solutions cater to a variety of industrial applications, including anti-slip technology that improves grip in numerous products. Setex's products are utilized across several sectors, such as industrial manufacturing, sports, medical, and consumer goods, empowering product designers and engineers to create unique, market-leading designs while overcoming limitations posed by traditional adhesives and gripping materials.

Revitalize Energy is a consumer-focused company that specializes in eye drops aimed at alleviating fatigue caused by prolonged screen use. The product features a patented blend of stimulants and amino acids that provides immediate energy and relief from digital eye strain. With just 1-2 drops in each eye, users experience a refreshing effect that helps combat tiredness and enhances comfort, making it an ideal solution for those frequently engaged with digital devices.

LeanFM Technologies is a developer of a cloud-based information and facility operations platform designed to assist facility managers in accessing actionable information for data-driven decision-making. The platform integrates static design information, dynamic measurements, and controls using standard communication protocols, allowing for the automatic mapping of data points from building automation systems to design drawings. By providing insights into maintenance history and backlog, the platform enriches building information with artificial intelligence, enabling clients to minimize waste and enhance value for both owners and occupants. LeanFM Technologies aims to improve the accuracy and productivity of operational facility managers across various sectors, including healthcare and education.

Respair is a medical device company focused on developing innovative airway products designed for critical care environments. The company's technology aims to enhance patient safety and comfort by replacing traditional inflatable cuffs on breathing tubes with soft, pliable baffles. These baffles function as effective stoppers, providing a comprehensive seal for the airway without exerting additional pressure. This design minimizes the risk of secondary complications, allowing patients to breathe more easily and safely during critical medical situations. Respair's products are intended to support clinicians in delivering high-quality care while improving patient outcomes.

Gus Gear specializes in the development and manufacturing of wearable securement clothing designed to protect implanted medical devices. The company's flagship product, the Central Line Vest, effectively prevents damage, breakage, and accidental removal of central catheters. By providing securement solutions for various medical devices, including ostomy pouches and feeding tubes, Gus Gear aims to enhance patient outcomes and quality of life. Their innovative approach enables patients to maintain a higher level of independence and well-being while undergoing medical treatment, allowing them to live their lives to the fullest despite any health challenges.

NOCTEM Health is a developer of a telehealth platform focused on addressing unmet sleep healthcare needs, particularly in the treatment of insomnia. The platform serves as a clinical decision support tool that enhances patient workflows and promotes safer behavioral sleep treatments. It features interactive and adaptive tools that integrate quality sleep care with the cost-efficiency of digital technologies. By enabling patients to connect with therapists, the platform facilitates real-time assessment, monitoring, and treatment for insomnia, nightmares, and other sleep disturbances, thereby empowering clinicians to provide effective sleep care to their patients.

Buoy is a manufacturer of hydrating wellness drops designed to enhance any beverage by adding essential electrolytes, vitamins, ionic trace minerals, and antioxidants. Recognizing that many individuals struggle to drink the recommended daily water intake, Buoy provides a solution that transforms ordinary drinks into functional beverages. The drops dissolve instantly and evenly, allowing users to improve their hydration without altering the taste of their favorite drinks. This product addresses the widespread issue of chronic dehydration, which affects a significant portion of the population and can lead to symptoms such as low energy, headaches, and increased blood pressure. By incorporating Buoy's drops, customers can effectively replenish lost electrolytes caused by various everyday activities, thereby promoting better hydration and overall wellness.

Voaige specializes in providing safe and versatile robotic arms to address labor shortages across various industries. The company is comprised of a dedicated team of AI PhDs and robotics engineers from Carnegie Mellon University, focused on leveraging cutting-edge artificial intelligence to tackle significant real-world challenges. Voaige also develops automation software that enhances tools automation, utilizing a deep space artificial intelligence platform. This technology allows robotic developers to automate previously unmanageable tasks efficiently, ultimately saving time and reducing costs for clients. By making advanced AI solutions more accessible, Voaige empowers businesses to incorporate automation into their production processes and operations effectively.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Inspired Cognition is a Pennsylvania-based company that specializes in developing artificial intelligence software and digital tools tailored for the research and development life cycle. The company focuses on creating operational guides and online systems that assist businesses in integrating AI solutions. Its offerings include evaluation as a service, which facilitates the development and monitoring of projects, along with data modeling capabilities. This enables professionals to identify system pain points and propose effective solutions, ultimately enhancing business performance and productivity.

UpContent, LLC is a technology company based in Pittsburgh, Pennsylvania, that specializes in content discovery solutions. Founded in 2015, it offers a software-as-a-service (SaaS) platform designed to enhance digital content curation for brands and improve audience engagement. The platform automates the process of discovering relevant news and blog articles, integrating with tools like Hootsuite and Buffer. Its features include the UpContent Gallery, which enables users to curate content, develop custom calls-to-action, and implement retargeting strategies to capture audience traffic. UpContent aims to simplify the search for quality content, empowering marketing, sales, and human resource teams to effectively share insights and foster meaningful conversations within their communities.

BioHybrid Solutions is a biotechnology company focused on the development of innovative nanoarmored protein-polymer conjugates. The company specializes in tailoring the activity and stability of proteins and enzymes for various applications, primarily through research and development efforts. Utilizing atom transfer radical polymerization chemistry, BioHybrid Solutions grows polymers with precision from the surface of proteins. This approach enables advancements in therapeutics and protein engineering, providing physicians with effective alternatives in their medical practices. The company's work bridges the fields of proteins and polymers, emphasizing direct product sales alongside its R&D initiatives.

Optimus Technologies is a clean energy technology company located in Pittsburgh, Pennsylvania, specializing in advanced fuel systems for medium and heavy-duty truck fleets. The company manufactures the Vector System, which allows diesel engines to operate solely on 100% biodiesel. This innovative technology facilitates a seamless transition to low-carbon fuels by integrating into existing engine operations without the need for significant modifications or replacements. By enabling fleet operators to run exclusively on biodiesel, Optimus helps reduce both fuel costs and emissions, addressing the challenges of achieving emissions reductions in heavy-duty applications while meeting renewable fuel targets.

Telling.ai is a telehealth platform focused on assessing lung health through the analysis of voice and breath sounds. By capturing respiratory sounds in real-world settings, the company provides real-time feedback and optimizes data quality to support individuals with chronic lung conditions. Their technology identifies signatures in breath and speech that indicate various medical conditions, including respiratory diseases and infections. Telling.ai aims to assist in the management of care for over 1 billion people suffering from acute or chronic respiratory disorders, enabling timely interventions that can prevent costly hospitalizations and improve overall patient outcomes.

Parcel Health is dedicated to revolutionizing medication packaging by offering the world's first fully brandable and compostable paper-based prescription bottle. This innovative product aims to replace traditional plastic bottles, contributing to sustainability efforts and helping pharmacies and pharmaceutical companies achieve carbon neutrality goals. Parcel Health's packaging not only enhances the safety and integrity of medications during shipping but also improves logistical efficiency, minimizing in-transit damage and bolstering customer satisfaction. Designed to be child-resistant and elder-friendly, the company’s solutions improve pharmacy workflows and reduce medication errors, positioning Parcel Health as a leader in eco-friendly pharmaceutical packaging.

DisSolves Inc. is a company that specializes in the development and manufacturing of dissolvable packaging materials aimed at the food industry. Founded in 2016 and based in Pittsburgh, Pennsylvania, the company produces edible packaging pods made from natural, plant-based ingredients. These pods are designed to hold single servings of drink mixes, such as protein powders and flavorings, providing a convenient and environmentally friendly alternative to traditional non-recyclable packaging. DisSolves prioritizes sustainability by utilizing renewable and sustainably sourced materials, including seaweed and polysaccharides, which not only reduce waste but also promote consumer well-being. Through its innovative approach, DisSolves aims to enhance the convenience of food packaging while contributing positively to environmental health.

MindTrace is a medical software company focused on enhancing neurosurgical procedures through the development of personalized 3D brain maps. By integrating advanced brain imaging with machine learning algorithms, the company creates simulations of surgical resection plans that allow neurosurgeons to predict patients' cognitive outcomes prior to surgery. This innovative approach enables surgeons to optimize the removal of brain tumors while minimizing damage to surrounding healthy tissue. Additionally, MindTrace's platform streamlines the process of analyzing brain imaging and behavioral data, reducing the time and effort required by medical teams. The company is supported by the Creative Destruction Lab, reflecting its commitment to advancing neurosurgical care.

BlastPoint specializes in big data solutions that enable companies to enhance revenue growth by effectively discovering, targeting, and engaging with their customer data. The company offers a predictive AI-powered platform that addresses customer engagement challenges, allowing businesses to find and satisfy their customers throughout their lifetime. BlastPoint serves a diverse range of sectors, including energy, finance, automotive, and nonprofit organizations, helping them identify trends and extract valuable insights specific to their territories or market dynamics.

Safe Space Technologies develops advanced robotic systems that utilize ultraviolet-C (UV-C) light disinfection technology to enhance workplace safety by effectively deactivating harmful pathogens. These robots serve as a superior alternative to traditional disinfection services, allowing for more thorough sanitization of various environments. By employing innovative disinfection methods, Safe Space Technologies aims to create safer working conditions and improve overall public health.

Subtl Beauty, Inc. is a cosmetics brand based in Pittsburgh, Pennsylvania, specializing in the production of stackable makeup products that cater to modern, fast-paced lifestyles. Founded in 2018, the company focuses on providing women with flexible and customizable makeup solutions through innovative packaging that allows for easy portability and organization. Their products are compact enough to fit in a gym bag or purse, making them ideal for on-the-go use. Each makeup formula is crafted for efficiency and long-lasting wear, aligning with the values of conscious consumers by being clean, vegan, cruelty-free, paraben-free, and fragrance-free. Subtl Beauty sells its products online, aiming to enhance the daily makeup routines of its customers with a cohesive and convenient experience.

Emergence Dental is a research and development medical device company established in 2019 and headquartered in Pittsburgh, USA. The company specializes in the design and pre-clinical development of innovative medical devices aimed at improving dental bone and soft tissue grafting procedures. Emergence Dental offers products made from metallic magnesium alloys, which safely resorb when implanted in the body. This technology enables oral surgeons and periodontists to reduce both the time and costs associated with dental bone grafting procedures for patients preparing to receive dental implants.

Voxable is a developer of a platform aimed at creating voice and chat applications for enterprises. The company's solution is designed to replace traditional tools such as spreadsheets, documents, and diagrams that teams typically use to design and manage conversations. By streamlining the conversation design process, Voxable enables organizations to communicate more effectively with their teams and stakeholders, enhancing collaboration and efficiency in their operations.

Honeycomb Credit, Inc. operates a peer-to-peer lending platform that connects small business owners with individual investors seeking to fund those businesses. Founded in 2017 and based in Pittsburgh, Pennsylvania, the company allows businesses to secure loans from their own customers and community members, facilitating debt crowdfunding. This innovative approach enables small businesses to obtain necessary capital without relinquishing equity, thus supporting their growth while providing a unique investment opportunity for lenders. By bridging the gap between traditional funding sources and community support, Honeycomb Credit enhances access to financial resources for small enterprises.

CleverApply is an educational administration platform established in 2020 and headquartered in Ohio, United States. The platform utilizes artificial intelligence and blockchain technology to assist students in identifying suitable universities based on their desired programs and needs. It facilitates connections between students, universities, and agents, allowing users to review necessary documents and prepare for interviews effectively. By streamlining the university selection process, CleverApply aims to enhance the overall experience for students seeking higher education opportunities.

Lumis specializes in advanced healthcare education by providing next-generation learning systems that enhance patient care. The company focuses on immersive, simulation-based training that incorporates augmented reality and automated instruction, allowing for individualized and on-demand learning accessible 24/7. Their technology is designed to transform traditional clinical training experiences into engaging and efficient learning opportunities. Lumis’ products can be integrated with various training mannequins, accommodating a wide range of budgets and training needs, from basic models to sophisticated, computer-controlled systems. By ensuring that high-quality training is available to healthcare professionals anytime and anywhere, Lumis aims to improve the preparation of clinicians for life-critical operations.

Roadies operates a blockchain-based web platform designed to enhance governance, transparency, and liquidity through a peer-to-peer exchange model. This platform allows visual artists to tokenize their artwork, offering shares to supporters who can buy and trade these tokens. By doing so, artists gain a new revenue stream and access to production capital, which aids in building sustainable careers. Additionally, this model fosters community engagement, as art enthusiasts can become shareholders in the works they admire. Overall, Roadies aims to revolutionize the art market by integrating technology with artistic expression.

TalkMeUp is a company focused on enhancing communication skills within the $100 billion corporate training market. It offers an artificial intelligence-based platform that provides on-demand, customized coaching for organizations aiming to bolster employee competence across various professional scenarios. Users can access a smart communications coach via their phones or computers, allowing them to receive instant, objective feedback on aspects such as delivery style and content by speaking into their cameras. This approach empowers employees in diverse roles, including retail, education, hospitality, sales, and customer service, by equipping them with essential communication skills tailored to their specific needs.

Element Exo specializes in the design and development of lightweight exoskeletons aimed at facilitating lifting and bending tasks for workers. The company's innovative technology focuses on assisting users by storing energy during bending movements and releasing it when standing up, all without the need for motors, batteries, or electricity. This approach not only enhances the ease of physical tasks but also significantly reduces the risk of overuse injuries related to repetitive lifting. By improving the health and well-being of wearers, Element Exo's products help mitigate the financial and time losses associated with debilitating back injuries, ultimately leading to increased productivity in the workplace.

AdSkate operates an advertising technology platform that leverages machine learning and artificial intelligence to enhance the ad buying and selling process. By providing multiple data points, AdSkate offers deeper insights and intelligence into digital content, which aids brands in effectively advertising themselves. The company's services encompass campaign planning, direct buy analysis, programmatic and custom integration, as well as content discovery and analysis. This comprehensive approach enables brands to make informed decisions when purchasing ad spaces, ultimately leading to more effective advertising strategies.

SpIntellx, Inc. is a computational and systems pathology company based in Pittsburgh, Pennsylvania, specializing in spatial intelligence software products for cancer diagnosis. Established in 2017, the company offers innovative solutions such as SpIntellx, which analyzes image data sets from various imaging platforms and reagent types, enabling precise analysis of pathology tissue sections. Additionally, SpIntellx provides HistoMapr, a computational guide for pathologists, and TumorMapr, which examines the spatial interactions of biomarkers within whole slide images using multiplexed fluorescence. By leveraging unbiased spatial analytics powered by explainable AI, SpIntellx aims to enhance the understanding of complex cancer biology, contributing to advancements in medicine and research across drug development, diagnostics, and treatment pipelines.

Komodo Analytics operates a platform that simplifies the municipal credit evaluation process. By integrating financial, demographic, and economic data, it offers municipal bond professionals a comprehensive view of a municipality's credit health and outlook. This consolidated approach enables asset managers and investors to make informed credit decisions efficiently, ensuring they have access to all necessary information for evaluating municipal bonds.

CapSen Robotics, Inc., founded in 2016 and based in Pittsburgh, Pennsylvania, specializes in advanced 3D computer vision systems that allow computers to interpret and navigate cluttered environments. The company offers a range of solutions, including cluttered object detection, scanning for both large and small objects, and object tracking, catering to diverse applications in factory automation, vehicle scanning, and retail inventory management. Drawing on research from MIT, CapSen’s technology enhances the capabilities of robots and computer vision systems, which are increasingly being utilized in less structured settings such as warehouses, hospitals, and homes. The company is currently beta testing its software with various system integrators and robotics firms, focusing on robotic picking applications and partnering with a major government contractor for a warehouse project. Their innovative object detection software has already demonstrated its effectiveness in competitive environments, such as a recent robotic order fulfillment competition.

TouchWood Labs, Inc., founded in 2019 and based in Pittsburgh, Pennsylvania, specializes in the development of innovative technology for office and home furniture. The company creates a unique hardware platform that features proprietary invisible displays, which can be embedded beneath surfaces like wood or plastic. These displays activate when needed, providing interactive touch interfaces for users to control various IoT-connected devices. TouchWood Labs aims to enhance user experience by merging technology with mindful design, ultimately fostering healthier relationships with technology through its product offerings, which include work-from-home desks and coffee tables.

Civic Champs, Inc. is a software development company that provides a mobile-based platform aimed at enhancing volunteer management for nonprofit organizations. Founded in 2019 and headquartered in Bloomington, Indiana, with an additional office in Pittsburgh, Pennsylvania, Civic Champs offers an application that allows nonprofits to digitally track volunteer hours and related information necessary for grant applications. The platform incorporates geofencing technology to facilitate automatic check-ins when a volunteer enters or exits a designated area. Additionally, it supports features such as time tracking, event scheduling, mentorship tracking, and donation acceptance. By automating these processes, Civic Champs helps organizations reduce manual data entry and improve volunteer engagement, ultimately allowing them to focus more on their missions. The application is accessible on both the App Store and Google Play.

Phlux Technologies, Inc. is a developer of advanced 3D sensor technology aimed at enhancing safety and efficiency in robotics and automation. Founded in 2020 and headquartered in Pittsburgh, Pennsylvania, the company focuses on creating programmable 3D sensors that enable robots to navigate safely and collaboratively in industrial environments. By replacing traditional physical barriers with digital safety zones, Phlux's innovative products utilize proprietary optical sensing technology, artificial intelligence, and computer vision. These sensors help protect workers from hazardous machinery and alert vehicles to obstacles, ultimately freeing up floor space, reducing setup times, and improving overall productivity. Phlux Technologies is dedicated to enabling the development of smarter robots and self-driving vehicles, contributing to safer industrial operations.

Revitalize Energy is a consumer-focused company that specializes in eye drops aimed at alleviating fatigue caused by prolonged screen use. The product features a patented blend of stimulants and amino acids that provides immediate energy and relief from digital eye strain. With just 1-2 drops in each eye, users experience a refreshing effect that helps combat tiredness and enhances comfort, making it an ideal solution for those frequently engaged with digital devices.

Naima Health is a healthcare technology company founded in 2018 and based in Pittsburgh, Pennsylvania. It specializes in developing health tools that utilize behavioral decision science and machine learning to enhance patient engagement in clinical care, particularly for pregnant women. The company's platform focuses on minimizing the risk of adverse pregnancy outcomes by offering a personalized and user-friendly pregnancy risk assessment and support tool. By combining individual-level input with statistical machine learning, Naima Health aims to empower at-risk women to better understand and communicate about their health risks, thereby facilitating access to necessary support and improving overall outcomes. The organization comprises a diverse team of researchers, scientists, and medical professionals committed to advancing maternal health.

Lanzhou cognitive intelligence platform is an industrial service cloud platform with NLP as the core, providing a series of services such as a graph, machine translation, assisted writing, sentiment analysis, intelligent retrieval, intelligent customer service, document analysis, etc. Enter search, generation, translation, dialogue, and other business scenarios. They provide solutions for financial, marketing, cultural, and creative industries, focusing on the core scenarios in the industry to provide solutions to help enterprises upgrade intelligently.

AlgenAir specializes in creating natural air purifiers that utilize algae to enhance indoor air quality. The company's innovative filter system effectively reduces carbon dioxide levels while simultaneously producing oxygen, offering an organic solution for improving the atmosphere in enclosed spaces. By harnessing the natural properties of algae, AlgenAir aims to provide a sustainable alternative to traditional air purification methods, contributing to healthier living environments for individuals.

Finish Robotics is focused on developing mobile robotics technology aimed at alleviating the labor shortage in the construction industry. The company specializes in creating semi-autonomous, collaborative robots that utilize standard industrial components. By leveraging this innovative technology, Finish Robotics enables contractors to effectively address the challenges faced by laborers on job sites, enhancing productivity and operational efficiency.

Module specializes in the development of modular housing projects that aim to provide innovative residential solutions for the urban environment. The company focuses on designing and constructing homes in a modular fashion, which allows for smart architectural designs to be accessible to a broader audience. By offering a pay-as-you-go model, Module enables potential homeowners to acquire the appropriate amount of living space tailored to their needs, making homeownership more affordable and flexible. The company's approach seeks to meet the demands of modern living while ensuring that customized housing services are available to its clients.

Spoken is a text-to-speech application based in Marietta, Ohio, designed to assist individuals facing challenges in communication. The company specializes in developing a predictive speech application that serves as a natural-language assistant for those with speech disorders. Utilizing big data and machine learning, Spoken employs user-centered design to deliver augmentative and alternative communication solutions. This technology helps users with conditions such as aphasia and nonverbal autism by predicting the next words they wish to express, enabling them to construct coherent sentences on their smartphones or tablets.

Conservation Labs, Inc., founded in 2016 and based in Brownsville, Pennsylvania, specializes in smart water management technology aimed at reducing water consumption and detecting leaks. The company offers a non-invasive water monitor that can be easily attached to existing water pipes. This device integrates with an application to provide real-time data on water usage, potential leaks, and appliance performance. By offering insights into water consumption, Conservation Labs enables property owners to identify opportunities for conservation, ultimately helping them save money and better manage this vital resource. The company addresses the significant issue of excessive water use in the U.S., which amounts to over 3 trillion gallons annually, costing billions in waste.

Telling.ai is a telehealth platform focused on assessing lung health through the analysis of voice and breath sounds. By capturing respiratory sounds in real-world settings, the company provides real-time feedback and optimizes data quality to support individuals with chronic lung conditions. Their technology identifies signatures in breath and speech that indicate various medical conditions, including respiratory diseases and infections. Telling.ai aims to assist in the management of care for over 1 billion people suffering from acute or chronic respiratory disorders, enabling timely interventions that can prevent costly hospitalizations and improve overall patient outcomes.

Creegh Pharmaceuticals specializes in the pharmaceutical preparation industry. It was founded in 2018 and headquartered in Pittsburgh, Pennsylvania.

Hava Health, Inc. is a biotechnology company based in the United States that specializes in developing innovative solutions for nicotine addiction. The company manufactures a smoking cessation device that includes a connected vape pen designed to assist individuals in their efforts to quit smoking. This device pairs with a smartphone application called Hale, which serves as a digital support tool for users undergoing nicotine de-addiction. Through its focus on combining technology with therapeutic approaches, Hava Health aims to provide effective support for those seeking to overcome nicotine dependence.

Miror is an online platform focused on fostering connections among individuals dealing with mental health issues. It facilitates group discussions led by certified mental health practitioners, allowing users to engage in conversations about their experiences and challenges. By creating a supportive community, Miror aims to help users overcome anxiety, find purpose, and make positive changes in their lives. The platform emphasizes the importance of connection and shared experiences in the journey towards mental well-being.

MindTrace is a medical software company focused on enhancing neurosurgical procedures through the development of personalized 3D brain maps. By integrating advanced brain imaging with machine learning algorithms, the company creates simulations of surgical resection plans that allow neurosurgeons to predict patients' cognitive outcomes prior to surgery. This innovative approach enables surgeons to optimize the removal of brain tumors while minimizing damage to surrounding healthy tissue. Additionally, MindTrace's platform streamlines the process of analyzing brain imaging and behavioral data, reducing the time and effort required by medical teams. The company is supported by the Creative Destruction Lab, reflecting its commitment to advancing neurosurgical care.

ESTAT Actuation, founded in 2019 and based in Pittsburgh, Pennsylvania, specializes in the development of electroadhesive clutches aimed at enhancing the capabilities and affordability of robots and machines. The company's innovative products provide engineers with advanced actuation hardware that reduces both the size and cost of traditional actuators. By offering lightweight and low-power clutches, ESTAT Actuation enables clients to improve the performance and efficiency of their robotic systems and machinery.

Stocksnips is an artificial intelligence platform designed to enhance investment decision-making by providing investors with timely access to stock market news analysis. The company employs advanced AI technologies, including natural language processing and neural networks, to crawl and analyze approximately 50,000 news articles daily related to public companies on major exchanges. By filtering out irrelevant information and assessing market sentiment, Stocksnips delivers valuable insights into a company’s financial and operational performance. It categorizes news snippets based on key performance indicators such as revenue, sales, and earnings, facilitating informed portfolio management for asset managers and investment advisors. Through partnerships with investment experts, Stocksnips aims to validate its analytical signals, ultimately helping clients achieve better investment outcomes and mitigate risks.

Equa Health operates a smartphone application designed as a mindfulness coach, focusing on meditation training. The platform aims to enhance resilience, happiness, and peak performance, particularly in workplace settings. Utilizing a scientific approach, Equa Health teaches users to manage stress and emotional regulation, helping them find relief from discomfort. This method enables individuals to build mental resilience and improve their overall satisfaction in personal relationships and professional goals.

CytoAgents, Inc. is a biotechnology company based in Pittsburgh, Pennsylvania, established in 2018. The company specializes in developing protein-based drugs aimed at treating viral infections, particularly influenza, and addressing life-threatening symptoms associated with Cytokine Release Syndrome (CRS). CRS is an overreaction of the immune system that results in systemic inflammation, often referred to as a cytokine storm. One of its primary products, GP1681, acts as an agonist of a G-protein coupled receptor, targeting the immune response in various medical conditions. CytoAgents focuses on creating treatments for multiple indications with significant unmet medical needs, including those arising from oncology CAR-T cell therapy, COVID-19, and respiratory epidemics, thereby providing healthcare professionals with innovative tools to manage patients experiencing severe immune reactions.

Endolumik makes minimally invasive surgical tools more visible using near infrared technology. Endolumik was headquartered in Morgantown, USA.

TouchWood Labs, Inc., founded in 2019 and based in Pittsburgh, Pennsylvania, specializes in the development of innovative technology for office and home furniture. The company creates a unique hardware platform that features proprietary invisible displays, which can be embedded beneath surfaces like wood or plastic. These displays activate when needed, providing interactive touch interfaces for users to control various IoT-connected devices. TouchWood Labs aims to enhance user experience by merging technology with mindful design, ultimately fostering healthier relationships with technology through its product offerings, which include work-from-home desks and coffee tables.

PECA Labs, Inc. is a medical device company based in Pittsburgh, Pennsylvania, focused on developing innovative solutions for pediatric cardiovascular care. Its primary product, the MASA Valve, is a synthetic heart valve designed for right ventricular outflow tract reconstruction in children. Utilizing advanced material properties of ePTFE, the MASA Valve addresses limitations associated with existing conduits, offering improved outcomes and reduced need for re-operation. This device has received Humanitarian Use Device designation from the FDA and has been successfully implanted in numerous patients. Additionally, PECA Labs offers exGraft, an ePTFE vascular graft marked for enhanced visibility during procedures. Founded as a spin-off from Carnegie Mellon University and UPMC, the company aims to enhance the quality of life for children with cardiac defects while minimizing the surgical interventions they face throughout their development.

Mamalux is an online retailer specializing in innovative, leakproof apparel designed for maternity and breastfeeding. The company offers a range of personal luxury items, including gowns for nursing women, handbags made from authentic materials, and comfort-focused sleepwear for postpartum mothers. By providing a variety of stylish and functional options, Mamalux aims to enhance the shopping experience for new mothers, allowing them to prioritize self-care while maintaining their look.

Ariel Precision Medicine is an integrated genomics and digital health company based in Pittsburgh, Pennsylvania, that focuses on providing precision medicine solutions for the diagnosis, monitoring, and treatment of complex chronic diseases. Founded in 2013, the company develops innovative clinical decision support tools designed to simplify personalized treatment, particularly through its flagship product, ArielDx. This cloud-based platform specifically aids in the diagnosis and management of pancreatic disease, enhancing the capabilities of healthcare providers in both emergency and clinical settings. Ariel Precision Medicine aims to improve patient outcomes by leveraging advanced technology and genomic insights in healthcare.

AdSkate operates an advertising technology platform that leverages machine learning and artificial intelligence to enhance the ad buying and selling process. By providing multiple data points, AdSkate offers deeper insights and intelligence into digital content, which aids brands in effectively advertising themselves. The company's services encompass campaign planning, direct buy analysis, programmatic and custom integration, as well as content discovery and analysis. This comprehensive approach enables brands to make informed decisions when purchasing ad spaces, ultimately leading to more effective advertising strategies.