IndieBio

Fermeate is a stealth-mode biotechnology company that specializes in photomolecular fermentation technology. This innovative approach aims to enhance sustainability and efficiency within the biomanufacturing industry.

Capro-X Inc., founded in 2017 and based in Ithaca, New York, is an ag-tech company focused on improving sustainability within the dairy industry. The company specializes in developing a fermentation bioprocess technology that converts acid whey, a byproduct of Greek yogurt production, into bio-oils. Capro-X offers WheyAway, a treatment technology utilizing naturally occurring, non-GMO microbes to transform dairy waste streams into clean water and natural bio-oils. This process occurs at the site of waste generation, addressing the environmental challenges posed by acid whey while producing valuable bio-oil from what would otherwise be discarded material. The company serves the dairy industry by providing a solution that enhances sustainability and increases yield over time.

Materia Bioworks is a pioneering company that develops data-driven informatics tools to facilitate the creation and adoption of sustainable biomaterials. Their AI-powered platform streamlines the process of developing and manufacturing biomaterial products, from sourcing materials to final production. This enables material scientists, product developers, suppliers, and converters to accelerate and enhance their work in biomaterial applications, fostering a more sustainable future across various industries.

Prellis Biologics, Inc. is a biotechnology company based in San Francisco, California, that specializes in bioprinting human tissues for drug development and organ transplantation. Founded in 2016, the company focuses on overcoming the challenges of creating vascularized human tissues and organs, aiming to revolutionize healthcare. Its innovative technology allows for the precise engineering of human tissues, including lymph node organoids, which can replicate human immune responses for various applications such as antibody discovery and tumor-immune modeling. Prellis Biologics offers a range of products, including TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X, which collectively enhance early-stage drug discovery and translational pharmacology.

PunaBio is a company based in Buenos Aires, Argentina, that specializes in developing biological products for the agricultural sector. Their focus is on enhancing crop nutrition through the use of extremophile microorganisms. These products are designed to boost yields, improve crop quality, and enable farming on degraded soils. By utilizing sustainable biological solutions, PunaBio aims to help farmers increase productivity and production while promoting environmentally friendly practices.

Particella is a biotechnology company that specializes in developing a proprietary oral lipid nanoparticle technology designed to deliver mRNA and other nucleic acids. This innovative approach aims to transform the administration of biological medicines by utilizing the intestinal tract to facilitate the secretion of proteins into the bloodstream. By enabling the oral delivery of protein biologics, Particella's technology seeks to address the limitations of current methods, ultimately allowing healthcare providers to prevent gastrointestinal diseases in patients more effectively. The company's advancements hold the potential to create a new category of medicines, enhancing the accessibility and efficacy of treatments.

Farm Minerals is a pioneering agricultural company that produces innovative, emissions-free NPK fertilizers at market prices, without compromising on quality or cost. Utilizing proprietary carbon capsule technology, the company enhances nutrient bioavailability, boosting efficiency up to 100 times compared to traditional inputs. By avoiding the Haber-Bosch process, Farm Minerals eliminates CO₂ emissions, reduces nutrient runoff, and minimizes waste. Its product line combines essential macro and microelements, promoting crop performance and animal health, and contributing to sustainable, high-yield agriculture.

Giraffe Bio specializes in developing biomolecular technology to enhance the efficiency and sustainability of critical mineral extraction. Their platform tailors biomolecules to the specific geology of each mine, boosting metal recovery, reducing water usage, and minimizing environmental impact. This is achieved by integrating biology, artificial intelligence, and hardware to optimize extraction processes, enabling clients to improve recovery rates and reduce extraction times.

Ten63 Therapeutics, Inc. is a biotechnology company based in Chapel Hill, North Carolina, focused on developing potent therapeutics for medically validated yet undruggable targets. Founded in 2017, the company utilizes its innovative platform, COPPER, which combines machine learning-based computational chemistry with advanced physical modeling to explore an extensive chemical space. This approach allows Ten63 Therapeutics to discover novel drug candidates for some of the most lethal diseases by employing proprietary algorithms for scaffold redesign and optimizing chemical design. By integrating these technologies, the company aims to produce durable therapies and improve drug resistance prediction, ultimately addressing challenges in drug development for previously intractable targets.

AlkaLi Labs is a biotechnology research company founded in 2023 and based in San Francisco, California. The company focuses on developing biological solutions to unlock domestic mineral resources. Currently operating in stealth mode, AlkaLi Labs aims to innovate in the field of biotechnology by leveraging natural processes to enhance resource extraction and sustainability.

Unlocked Labs specializes in the development of genetically optimized probiotics aimed at addressing chronic health conditions. The company focuses on activating dormant microbial abilities within a safe and established framework. Its rigorously tested probiotic strains are specifically designed to target and eliminate harmful compounds in the gastrointestinal tract. Unlocked Labs' inaugural product is formulated to reduce the risk of kidney stones by digesting stone-forming compounds that may be ingested from healthy foods, such as leafy vegetables. By utilizing alternative regulatory pathways, the company seeks to expedite the availability of safe and effective probiotic solutions for consumers, enabling them to detoxify their bodies and manage acid levels affordably and effectively.

BioLattice is a biotechnology company focused on developing tissue-engineered cornea technology. Their primary goal is to provide a viable alternative to donor tissue for full-thickness corneal transplants. The company's innovative technology offers a corneal prototype with vision-correcting capabilities, aiming to restore sight for patients requiring corneal transplants.

Vitarka Therapeutics is a London-based company that specializes in developing medical technologies and solutions aimed at treating various types of cancer. The company has created a targeted non-viral delivery platform designed for intracellular targets, particularly in oncology, neuroscience, and neurodegeneration. This innovative platform works by activating the immune system and normalizing tumor vasculature, significantly improving outcomes for late-stage cancer patients, including those with lung, colon, and breast cancers. By utilizing re-engineered pore-forming proteins, Vitarka Therapeutics enables cell-specific targeting and endosomal release of therapeutic cargo, providing cancer patients with improved prospects for leading normal lives and maintaining hope for the future.

ViAn Therapeutics is an early-stage biotechnology company dedicated to innovating treatments for retinal diseases. The company is developing a first-in-class, non-invasive eyedrop treatment aimed at replacing traditional invasive injections for conditions such as age-related macular degeneration and diabetic macular edema. With robust preclinical data and ongoing clinical testing, ViAn is poised to address significant unmet medical needs within the retinal disease sector, which represents a substantial market opportunity. In addition to its focus on ophthalmology, ViAn is also engaged in creating peptide drugs designed to inhibit angiogenesis, potentially benefiting patients suffering from cancer and other angiogenesis-dependent diseases. Through its innovative approaches, ViAn Therapeutics seeks to enhance patient outcomes and improve the overall quality of life for individuals affected by these conditions.

Asterix Foods is a biotechnology company based in Tel Aviv, Israel, founded in 2022. The company specializes in developing protein production through plant-cell culture techniques, focusing on the creation of bioactive proteins for food applications. Asterix Foods aims to provide scalable, functional, and complex proteins that are derived from plant cell cultures, offering an animal-free alternative for consumers.

Sci-Lume Labs specializes in the development of innovative, bio-based and biodegradable fibers designed to replace conventional petrochemical fibers like nylon and polyester. Their high-performance materials maintain the functionality and versatility of traditional synthetics while addressing environmental concerns, catering to textile and apparel manufacturers seeking sustainable alternatives.

Ceal is a Climate Tech Manufacturing firm making energy efficient technology for carbon dioxide removal.

Quorum Earth, based in Brooklyn, New York, is a pioneering agricultural technology company. It specializes in the development of innovative, eco-friendly pesticides, harnessing the power of the fungal kingdom to create products that are safe for the planet and effective in controlling pests. Currently, the company operates in stealth mode.

Sun Genomics, Inc. is a microbiome health company based in San Diego, California, specializing in customized probiotics aimed at addressing dysbiosis. Founded in 2014, the company’s flagship product, Floré, combines a gut microbiome test with personalized probiotic formulations tailored to individual gut profiles, assessed through whole-genome sequencing. The Floré Gut Test includes a microflora collection kit, a comprehensive microflora profile analysis, and wellness consultations. Additionally, Sun Genomics offers Floré Tots, a probiotic solution designed for children up to age 12, which comes in a convenient powder form that can be easily mixed with beverages. The company sells its products online, providing an automatic renewal service to enhance customer convenience.

Capra Biosciences is a biotechnology company focused on the sustainable and efficient production of everyday chemicals through innovative bioreactor technology. The company has developed a biofilm bioreactor that aims to streamline the bio-manufacturing process, effectively reducing downstream processing requirements and associated costs. This technology not only enhances the production efficiency of bio-based chemicals but also enables the creation of hydrophobic products, including retinol and performance lubricants. By harnessing biological processes, Capra Biosciences contributes to a low-carbon future while addressing the growing demand for sustainable chemical solutions.

Synplexity is a biotechnology company located in New Castle, Delaware, specializing in mutational scanning and multiplexed gene synthesis through advanced artificial intelligence technology. The company operates a large-scale gene synthesis and proteomics discovery platform that utilizes microdroplets as microreactors. This innovative approach allows for the efficient creation of multiplex gene libraries, which have applications across various sectors, including therapeutics, biomanufacturing, agriculture, and climate systems. Synplexity aims to drive advancements in healthcare and other industries through its cutting-edge genetic technologies.

Laguna Bio is a biotechnology company focused on cancer treatment through its innovative drug discovery platform. Founded in 2022 and headquartered in Berkeley, California, the company specializes in selectively activating and expanding the innate immune system to combat solid tumors. By enhancing the response rate of bispecific antibody drugs, Laguna Bio aims to provide specific T cells that strengthen the immune system's ability to fight cancer, ultimately improving survival rates for patients facing this deadly disease.

FREZENT is a biotechnology company focused on developing innovative therapeutics for advanced-stage cancer patients. It specializes in creating biological inhibitors that target cancer-specific lipid metabolism, aiming to prevent the reactivation of dormant cancer cells.

NanoPlume is a biomaterial manufacturer specializing in the large-scale production of innovative, eco-friendly biomaterials, notably Bio-Aerogel. The company focuses on creating advanced insulating biomaterials and aerogels, aiming to enhance energy and space efficiency, as well as promote circularity across various industries. By utilizing organic and recycled feedstocks and green technology, NanoPlume reduces waste and minimizes energy consumption. Its products are designed to insulate cargo boxes in the cold chain healthcare logistics sector, reducing payload and energy consumption, and extending battery range.

Bactery is a manufacturer of innovative bacteria-powered batteries, known as bacteries, which harness microbial processes in soil to self-recharge. This technology offers a continuous source of clean electricity, functioning effectively regardless of weather conditions or geographic location. Bactery's environmentally friendly batteries are particularly suited for powering remote applications, such as field sensors and Internet of Things (IoT) devices, making them an ideal solution for sustainable energy needs in agriculture and other sectors.

Huue is a company specializing in sustainable dyeing solutions for the fashion and textile industries, particularly focusing on the denim supply chain. It employs innovative biotechnology to produce bio-synthesized dyes through a fermentation process involving naturally occurring microorganisms. This method not only eliminates the need for toxic chemicals traditionally used in dye production but also utilizes renewable resources, making it an eco-friendly alternative. By offering greener options for color production, Huue aims to support the industry's transition towards more sustainable practices, ultimately contributing to a more environmentally responsible approach to fashion.

DisperseBio is a Biotechnology Research firm developing a mechanism to counter microbial contamination on natural surfaces like human body.

Metabolic Psychiatry Labs is a mental healthcare company that provides remote treatment solutions for mental illnesses. Their platform integrates metabolic and mental health research, data tracking, metabolic interventions, and personalized medical care, enabling patients to receive effective treatments from home. The company offers assessments, lab tests, and wellness solutions based on metabolic therapy.

Mothership Materials specializes in converting agricultural waste into valuable biomolecules using its proprietary Targeted Molecular Recovery (TMR) technology. The company's process efficiently extracts proteins, lipids, antioxidants, sugars, and cellulose from waste streams, enabling agricultural producers and waste managers to create a circular economy and maximize waste value.

Minutia is a biotechnology company focused on developing innovative stem cell-derived transplants aimed at treating Type 1 Diabetes. The company specializes in creating insulin-producing cell transplants that incorporate proprietary nanosensors, allowing for real-time monitoring of transplant status. These immune-evasive cells are designed for subcutaneous implantation, addressing common challenges associated with transplant procedures. By advancing this technology, Minutia seeks to transform the clinical landscape for diabetes management and cell replacement therapies, ultimately working towards a functional cure for this condition.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Sóliome is a biotechnology company based in San Francisco, California, founded in 2021. The company specializes in the development of protein-based sunscreens designed to be safe for both human use and the environment. Sóliome's innovative products aim to reduce the absorption of harmful chemicals found in traditional sunscreens, which can contribute to skin inflammation and ecological damage. By focusing on skin protection from harmful rays while minimizing environmental impact, Sóliome addresses growing concerns about both personal health and sustainability in skincare.

BioMetallum is a biomining company specializing in sustainable metal extraction. It designs and develops solutions, primarily focused on lithium, using microorganisms to enhance efficiency and minimize environmental impact. The company's services promote a circular economy, aiming to enable a healthier, more sustainable society.

Calyx specializes in developing advanced sensor technology focused on monitoring environmental parameters, particularly in the poultry and livestock sectors. The company integrates artificial intelligence, computer vision, and bio-engineered sensors to create versatile platforms capable of detecting airborne chemical emissions with high specificity and sensitivity. Its innovative sensors are designed using patterned viruses that bind to specific gas molecules, allowing for accurate detection of various airborne chemicals. This technology not only addresses complex challenges in livestock management but also enables commercial customers to monitor and respond to daily environmental health changes effectively.

Asta Bio is a biotechnology company specializing in the development of radiotherapeutics for cancer treatment. It focuses on combining the alpha-emitting radioisotope 211-Astatine with multivalent single-domain antibodies to deliver targeted alpha radiation to tumor cells, sparing healthy cells. This approach aims to effectively destroy cancer cells by breaking their DNA strands.

DNAzyme is a biotechnology company specializing in the development of enzymes derived from Antarctic extremophile microorganisms as active ingredients for skin health applications. Utilizing recombinant DNA repair technology, the company produces highly pure enzymes at an industrial scale, enabling clinicians to create innovative solutions for skin health and rejuvenation in both the cosmetic and pharmaceutical industries.

PhytoGenesis is a company that specializes in developing sustainable plant protection products. It focuses on creating safe and non-toxic alternatives to traditional fungicides and pesticides, using plant-based compounds. The company's technology ensures effectiveness across a broad spectrum of crops, including grains, feed, fiber, oil, vegetables, and fruits. PhytoGenesis aims to minimize environmental impact while maintaining crop health and productivity, contributing to global food security.

Tinkeso Therapeutics is a biotechnology company specializing in the development of innovative, off-the-shelf cell therapies for treating cancer and autoimmune diseases. The company focuses on creating allogeneic chimeric antigen receptor (CAR) engineered natural killer T (NKT) cell therapies, which use NKT cells to target and destroy cancer cells or modulate the immune response in autoimmune conditions. This approach aims to increase treatment accessibility and scalability by utilizing non-patient-specific cells.

microTERRA is a company dedicated to developing sustainable food ingredients by utilizing Lemna, an aquatic plant known for its water-cleaning properties and ability to produce valuable functional ingredients. Their flagship product, Flora, enhances sweetness perception while reducing sugar content in formulations, effectively masking unwanted notes from high-intensity sweeteners without compromising texture or taste. This innovation addresses a significant market opportunity within the food industry. microTERRA operates as an ingredient platform, focusing on creating specialty ingredients through sustainable methods.

BugBiome is a biotechnology company that develops eco-friendly bio-repellents to create natural pest control products. It focuses on identifying and enhancing beneficial microbes that deter pests organically, providing an alternative to traditional chemical methods. The company aims to minimize environmental impact and promote sustainable pest management practices, potentially benefiting sectors such as agriculture and households.

heXem bio specializes in recording solutions for the early development of humans for longevity.

Restoring crops' ability to defend against pests.

Fermeate is a stealth-mode biotechnology company that specializes in photomolecular fermentation technology. This innovative approach aims to enhance sustainability and efficiency within the biomanufacturing industry.

Capro-X Inc., founded in 2017 and based in Ithaca, New York, is an ag-tech company focused on improving sustainability within the dairy industry. The company specializes in developing a fermentation bioprocess technology that converts acid whey, a byproduct of Greek yogurt production, into bio-oils. Capro-X offers WheyAway, a treatment technology utilizing naturally occurring, non-GMO microbes to transform dairy waste streams into clean water and natural bio-oils. This process occurs at the site of waste generation, addressing the environmental challenges posed by acid whey while producing valuable bio-oil from what would otherwise be discarded material. The company serves the dairy industry by providing a solution that enhances sustainability and increases yield over time.

Oobli is a food company focused on developing innovative protein sweeteners derived from exotic plants. These unique sweeteners offer a delicious taste while significantly reducing calories, making them a healthier alternative to traditional sugars. Produced through fermentation, Oobli's sweeteners have no glycemic impact and do not influence the gut microbiome, allowing consumers to enjoy sweetness without concerns related to blood sugar, insulin, or weight management. The company has successfully obtained regulatory approvals, including FDA "no questions" letters and GRAS status for multiple protein sources, which positions it as a leader in the healthy sweetener market. By transforming flavors, Oobli aims to enhance everyday food experiences while promoting better health outcomes for its users.

CellCrine focuses on discovering enzymes that transform cell culture for the cell-based meats industry. CellCrine was founded in 2021and was headquartered in United, States.

Transition Biomining is a technology-focused company specializing in copper ore mining. It employs data-driven methods to enhance copper extraction and mining efficiency. The company's core innovation lies in optimizing microbial communities for heap-leaching operations, aiming to boost metal recovery rates, expedite extraction, and minimize environmental impact. By harnessing the power of microbiomes, Transition Biomining provides sustainable and data-driven solutions to improve clients' extraction processes in both new and existing heap-leaching operations.

MycoWorks is a biotech company that specializes in producing sustainable materials derived from mycelium, the root structure of fungi. By utilizing this natural resource, MycoWorks offers innovative alternatives to conventional plastic foams, synthetic textiles, and leather. Their products are designed to be energy-efficient and biodegradable, catering to various industries, including aerospace, automotive, apparel, and architectural interiors. Through a carbon-negative process, the company transforms agricultural byproducts and mycelium into high-quality materials, allowing clients to access rapidly grown, eco-friendly leather substitutes. MycoWorks aims to address environmental concerns associated with traditional materials while promoting the use of bio-based solutions.

NovoNutrients is a pioneering biotechnology company specializing in the conversion of waste CO2 emissions into high-value proteins and additives for use in food and animal feed. The company's proprietary technology employs advanced gas fermentation systems and custom microbes to transform industrial waste CO2, hydrogen, and oxygen into safe, natural single-cell protein ingredients. This innovative process not only addresses global food security by providing a sustainable alternative protein source but also contributes to climate change mitigation through carbon capture and utilization.

OncoPrecision is a biotechnology company focused on enhancing cancer treatment through its innovative patient micro avatar platform. This platform utilizes single-cell high-throughput biology and advanced machine learning techniques to develop comprehensive patient-derived phenotypic biomarkers. By tailoring cancer therapies to individual patients, OncoPrecision aims to significantly increase the success rates of treatments. The company's approach enables oncologists to make informed, data-driven decisions regarding therapy selection based on unique patient samples, thereby improving outcomes in cancer care.

BugBiome is a biotechnology company that develops eco-friendly bio-repellents to create natural pest control products. It focuses on identifying and enhancing beneficial microbes that deter pests organically, providing an alternative to traditional chemical methods. The company aims to minimize environmental impact and promote sustainable pest management practices, potentially benefiting sectors such as agriculture and households.

Avalo is a plant biology company that employs interpretable machine learning, genomic discovery, and evolutionary theory to expedite the development of new crops tailored for future agricultural needs. Utilizing AI-assisted plant breeding methods, Avalo creates non-GMO products that foster natural biodiversity. Its core technology, a discovery engine, can swiftly identify genetic bases of complex traits even in understudied crops, reducing time and cost significantly compared to traditional methods. This enables Avalo to forecast and enhance crop traits like drought tolerance and nutrient density, adapting agriculture to changing climates.

Farm Minerals is a pioneering agricultural company that produces innovative, emissions-free NPK fertilizers at market prices, without compromising on quality or cost. Utilizing proprietary carbon capsule technology, the company enhances nutrient bioavailability, boosting efficiency up to 100 times compared to traditional inputs. By avoiding the Haber-Bosch process, Farm Minerals eliminates CO₂ emissions, reduces nutrient runoff, and minimizes waste. Its product line combines essential macro and microelements, promoting crop performance and animal health, and contributing to sustainable, high-yield agriculture.

HelEx is a biotechnology company founded in 2021 and based in New York, specializing in genomic medicines tailored for renal indications. The company utilizes its proprietary genomics data and bioinformatics to develop, validate, and distribute therapy-specific guide RNAs (gRNAs). HelEx's innovative platform leverages data-driven deep-learning modeling, utilizing high-throughput next-generation sequencing data derived from CRISPR edits on human cell lines. This approach provides reliable predictions and allows for in-house validation, thereby facilitating the acceleration of drug discovery and the development of cell and gene therapies in the CRISPR-based market.

Calder Biosciences is a biotechnology company focused on developing advanced vaccines to combat life-threatening viruses. Recognizing that traditional vaccines often fail to provide adequate protection against evolving viral threats, Calder employs its proprietary 3D-Vaxlock technology, which utilizes structure-based design to enhance the stability and efficacy of vaccine candidates. This innovative platform creates molecular staples that maintain vaccines in their most effective configurations, addressing the common shortcomings of subunit vaccines, such as limited potency and shelf-life. Calder's current projects include a universal flu vaccine aimed at covering all seasonal strains and a respiratory syncytial virus (RSV) vaccine tailored for the elderly. By prioritizing the development of vaccines with exceptional safety, efficacy, and durability, Calder aims to reduce severe disease and mortality rates while alleviating the burden on healthcare systems, ultimately contributing to healthier lives for vulnerable populations.

ClimateCrop, founded in 2021 and based in Ness Ziona, specializes in agricultural technologies that enhance the ability of plants to store carbon and energy. The company employs gene editing techniques to optimize the performance of crops, enabling them to harness greater energy and improve resilience against extreme weather conditions. This innovative approach not only facilitates better adaptation to current and future climate challenges but also supports agricultural companies in achieving higher yields, whether in biomass or fruit production.

Finless Foods Inc. is a biotechnology company based in Emeryville, California, that specializes in producing seafood products for human consumption using cellular-agriculture technologies. Founded in 2017, the company focuses on cultivating marine-animal cells to create sustainable fish and seafood alternatives, including bluefin tuna. Finless Foods aims to provide a variety of food options that cater to diverse tastes and dietary preferences while promoting responsible production practices. By offering accessible plant-based and cell-cultured seafood alternatives, the company seeks to contribute to better ocean health and foster a more sustainable future for food consumption.

Bloomlabs provides a method to catalyze waste value by regenerating it as adaptable and appealing bio-plastics and textile fibers. It envisions a future in which outmoded, resource-intensive processes are phased out in favor of cutting-edge, sustainable, and scalable alternatives.

Cayuga Biotech is a startup focused on the development of innovative hemostatic drugs and devices aimed at reducing uncontrollable bleeding, a major cause of death from traumatic injuries. The company utilizes a polyphosphate-based drug that enhances the body's natural clotting process at the injury site, thereby minimizing the risk of side effects associated with bleeding. Cayuga's pipeline includes a clinic-ready drug designed for life-threatening hemorrhage and additional therapeutics in the discovery stage targeting rare inherited bleeding disorders, central nervous system bleeding, severe burns, and non-healing wounds. Through its biomimetic therapeutics technology, Cayuga Biotech seeks to harness the body's innate ability to promote healing and improve survival rates, while also reducing disability resulting from trauma.

California Cultured is a food company based in Davis, California, that specializes in creating sustainable, lab-grown cocoa and coffee through advanced cellular agriculture techniques. Founded in 2020, the company focuses on producing cocoa that is less bitter and requires less sugar, while also ensuring its products are healthier for consumers. By stimulating cocoa cell growth using common food ingredients, California Cultured aims to provide high-quality cocoa products that are free from the ethical issues traditionally associated with cocoa production, such as slavery and deforestation. This innovative approach allows customers to enjoy delicious and sustainable cocoa without the environmental and social drawbacks of conventional methods.

NuKoKo is a manufacturer that specializes in creating cocoa-free chocolate through innovative bean-to-bar processes. The company utilizes ingredients sourced from the UK and has developed patent-pending technology to produce a new type of chocolate that is healthier and more sustainable than traditional options. NuKoKo's products are characterized by low carbon emissions, low sugar content, and high protein levels, allowing consumers to enjoy chocolate while minimizing environmental impact. The focus on healthier, sustainable alternatives positions NuKoKo as a unique player in the chocolate industry, appealing to environmentally conscious consumers.

AquaLith Advanced Materials specializes in the development of innovative lithium-ion battery materials. The company has secured exclusive rights to a portfolio of patents from the University of Maryland, which focus on advancements made by researchers in the field of chemical and materials engineering. AquaLith's technology includes an ultra-high energy cathode, a novel silicon anode, and a non-flammable aqueous electrolyte, all designed to enhance the performance of lithium-ion batteries. This technology addresses key challenges such as efficiency in low temperatures, faster charging times, and improved safety by reducing fire risks associated with short circuits. The company's materials aim to provide high energy density while being cost-effective and abundant, ultimately benefiting consumer electronics and other applications in need of reliable battery solutions.

Avisa Myko Inc. is a biotechnology company based in San Francisco, California, specializing in the production of natural, water-soluble melanin through precision fermentation technology. This innovative approach allows the company to manufacture melanin at scale and at an affordable cost, making it suitable for diverse applications across various industries. Avisa Myko's melanin serves multiple purposes, including protection against ionizing radiation and use in electricity generation. Its high-purity melanin is easily redissolved, facilitating incorporation into products such as cosmetics, biomedicine, organic semiconductors, biosensors, latex products, and fabrics. The company is also developing a prototype sunscreen that utilizes melanin as an ultraviolet blocker, distinguishing itself by avoiding traditional chemical or mineral UV blockers. Through its patented technology, Avisa Myko aims to contribute to better health and environmental sustainability.

Producer of plant-based protein intended to decarbonize supply chains by creating valuable products from underutilized waste from other industries. The company offers a sustainable plant-based protein that is produced from spent grains by transforming the unused part of the grain from beer manufacturing into functional vegan protein, enabling clients to get products that replace the need for soy and pea protein in meat and dairy replacements

Reactosome is a biotechnology company that develops synthetic nuclei for gene therapy. Its core product, a synthetic nucleus, operates continuously within cells, mimicking the natural nucleus to affect multiple genes simultaneously. This approach aims to enhance the safety and longevity of gene expression, thereby enabling the development of treatments for complex diseases such as cancer and age-related disorders.

Bioeutectics is a company focused on enhancing the sustainability of industrial processes by providing high-performance, natural solvents. Utilizing proprietary eutectic technology, Bioeutectics mimics the natural solvent production methods of plants and relies on 100% renewable resources. This innovative approach enables the company to replace traditional petrochemical solvents with eco-friendly alternatives in various industries, including food, pharmaceuticals, and personal care. The solvents produced are non-toxic, biodegradable, and customizable, allowing for tailored solutions that meet specific industry needs while promoting environmental responsibility. Through its commitment to sustainable practices, Bioeutectics positions itself as a leader in the production of green solvents, contributing to a more sustainable future.

ZymoChem, Inc. is a biotechnology company based in Emeryville, California, founded in 2013. The company specializes in developing microbes and bioprocesses that convert renewable feedstocks, such as sugars, into bio-based chemicals. ZymoChem's innovative platform focuses on creating eco-friendly chemical solutions while minimizing carbon dioxide emissions during production. By engineering novel microbes and establishing cost-effective bioprocesses, the company enhances the biological conversion of renewable materials into various industrial chemicals. This approach not only lowers production costs for clients but also contributes to sustainability by promoting a carbon-efficient manufacturing process. ZymoChem aims to support the transition to a real-zero economy by providing alternatives that reduce carbon emissions across product development, usage, and disposal.

Chronus Health, Inc. is a medical technology company that specializes in developing a portable diagnostic device capable of delivering rapid point-of-care lab results, specifically for complete blood count and comprehensive metabolic panel tests. Founded in 2017 and headquartered in Mountain View, California, the company utilizes advanced microfluidics and semiconductor technology, combined with data analytics, to provide healthcare providers with real-time diagnostic capabilities. This innovative system allows for the delivery of lab results within minutes, significantly enhancing the speed of diagnosis and improving patient outcomes by enabling timely and informed treatment decisions.

Voyage Foods is a company dedicated to securing the future of beloved foods by addressing health, environmental, and social challenges. Through the use of natural, sustainable, and upcycled ingredients combined with proprietary technology and food science, Voyage creates delicious alternatives that mimic the taste and appearance of traditional foods without compromising on nutrition or sustainability. Their initial product lines include nut-free spreads, cocoa-free chocolate, and bean-free coffee, offering consumers a way to enjoy their favorite treats responsibly.

Sun Genomics, Inc. is a microbiome health company based in San Diego, California, specializing in customized probiotics aimed at addressing dysbiosis. Founded in 2014, the company’s flagship product, Floré, combines a gut microbiome test with personalized probiotic formulations tailored to individual gut profiles, assessed through whole-genome sequencing. The Floré Gut Test includes a microflora collection kit, a comprehensive microflora profile analysis, and wellness consultations. Additionally, Sun Genomics offers Floré Tots, a probiotic solution designed for children up to age 12, which comes in a convenient powder form that can be easily mixed with beverages. The company sells its products online, providing an automatic renewal service to enhance customer convenience.

Unlocked Labs specializes in the development of genetically optimized probiotics aimed at addressing chronic health conditions. The company focuses on activating dormant microbial abilities within a safe and established framework. Its rigorously tested probiotic strains are specifically designed to target and eliminate harmful compounds in the gastrointestinal tract. Unlocked Labs' inaugural product is formulated to reduce the risk of kidney stones by digesting stone-forming compounds that may be ingested from healthy foods, such as leafy vegetables. By utilizing alternative regulatory pathways, the company seeks to expedite the availability of safe and effective probiotic solutions for consumers, enabling them to detoxify their bodies and manage acid levels affordably and effectively.

RyboDyn is a biotechnology research company focused on developing innovative therapeutics aimed at training the immune system to identify and eliminate cancer from within the body. By leveraging cutting-edge scientific breakthroughs, RyboDyn creates advanced treatments that promise significant improvements in the management of terminal diseases and various ailments. The company's commitment to enhancing medicine through its research positions it at the forefront of the fight against cancer, with the potential to transform patient care and outcomes.

Prellis Biologics, Inc. is a biotechnology company based in San Francisco, California, that specializes in bioprinting human tissues for drug development and organ transplantation. Founded in 2016, the company focuses on overcoming the challenges of creating vascularized human tissues and organs, aiming to revolutionize healthcare. Its innovative technology allows for the precise engineering of human tissues, including lymph node organoids, which can replicate human immune responses for various applications such as antibody discovery and tumor-immune modeling. Prellis Biologics offers a range of products, including TissueWorkshop, Organoids, Vascular Bundles, Tissue Chips, and Holograph X, which collectively enhance early-stage drug discovery and translational pharmacology.

Hypercell Technologies specializes in developing innovative tools for controlling infectious diseases in animals. The company's core focus is on creating rapid, accurate diagnostic tools using molecular biology techniques, which enable veterinarians to detect and manage infections swiftly. Additionally, Hypercell develops monoclonal antibodies designed to proactively control viruses in production animal reservoirs, aiming to prevent potential zoonotic disease outbreaks in humans by addressing the source in animals.

Lillianah Technologies is a company dedicated to developing innovative carbon capture technology aimed at restoring marine ecosystems affected by pollution and other environmental challenges. Comprising a team of scientists, Lillianah focuses on optimizing the biological pump in oceans, which is crucial for maintaining ecological balance. By harnessing the ocean's potential, the company seeks to address the detrimental impacts of human activity, such as fertilizer runoff, and contribute to reversing environmental degradation. Through its efforts, Lillianah Technologies aspires to create sustainable solutions that benefit both the oceans and the broader environment.

BioFluff is a manufacturer specializing in plant-based fur designed to serve the fashion industry by providing a sustainable alternative to animal and plastic fur. The company utilizes a patented process along with retrofitted equipment to ensure a scalable production of its eco-friendly materials. Sourced from organic renewable fiber plants, BioFluff’s products are developed without gene splicing, gene editing, or the use of petrochemicals and unsustainable raw-oil derivatives. This commitment to sustainability extends to its customization services, allowing clients to personalize their materials according to specific features such as fur length, fiber density, color, top fur strength, bottom fur insulation properties, and suppleness. By combining innovation with customization options, BioFluff aims to meet the growing demand for luxury, sustainable textiles within the fashion industry.

Pyrone Systems, established in 2021, specializes in the development of biopesticides that integrate biology with chemistry. The company focuses on creating safe, effective, and sustainable products through innovative, biology-based methodologies. Pyrone Systems aims to produce bio-based chemicals that can replace harmful petrochemicals, contributing to environmental sustainability and promoting safer agricultural practices. By prioritizing a biology-driven approach, the company seeks to provide efficient alternatives that minimize the ecological impact of traditional chemical products.

RizLab Health is a medical device startup founded in 2018 and based in East Princeton. The company specializes in providing rapid blood count analysis through its innovative electronic cytometer and analyzer. This device utilizes a cartridge system to quantify key cellular components of white blood cells, facilitating quick and accurate assessments of patients' health. RizLab Health's technology is designed to be portable and cost-effective, enabling healthcare practitioners to monitor white blood counts, neutrophils, and lymphocytes efficiently. This capability is particularly valuable in clinical scenarios such as diagnosing sepsis or determining the presence of bacterial or viral infections, enhancing decision-making in patient care.

FREZENT is a biotechnology company focused on developing innovative therapeutics for advanced-stage cancer patients. It specializes in creating biological inhibitors that target cancer-specific lipid metabolism, aiming to prevent the reactivation of dormant cancer cells.

BioAesthetics LLC, founded in 2015 as a spin-out from Tulane University, is dedicated to improving reconstruction options for breast cancer patients post-mastectomy. The company specializes in developing tissue-engineered nipple-areolar complex (NAC) grafts, which are designed to be used during the breast reconstruction phase. These off-the-shelf, acellular NAC grafts serve as a framework for the patient's own cells to regenerate their nipple and areola, providing a more natural outcome. The company is based in New Orleans, Louisiana.

Gatehouse Bio is a biotech company based in Waltham, Massachusetts, founded in 2016. The company specializes in the development of therapies utilizing a novel bioinformatics platform that focuses on small ribonucleic acid (RNA) biomarkers. This platform is designed to classify patient samples with binary accuracy and identifies disease-associated mutations, enabling the creation of targeted therapeutics. By employing artificial intelligence, Gatehouse Bio aims to analyze small RNA genes and design oligonucleotides that can effectively counteract the effects of these mutations. Their research and development efforts target therapeutic areas with known heterogeneity, such as fibrosis, inflammation, and neurodegeneration, with the goal of unlocking the potential for improved patient outcomes through personalized medicine.

Diptera.ai is a Jerusalem-based company specializing in innovative mosquito control solutions. The firm has developed a technology that employs the sterile insect technique, utilizing advanced optics, computer vision, and artificial intelligence. Its ready-to-use module is designed to release sterile male mosquitoes over several weeks, allowing municipal corporations to implement large-scale mosquito control initiatives effectively. This approach eliminates the need for traditional mosquito rearing and sorting facilities, making the technology more affordable and accessible for municipalities. By focusing on biological solutions, Diptera.ai aims to address the challenges posed by mosquito-borne diseases and improve public health outcomes.

Calder Biosciences is a biotechnology company focused on developing advanced vaccines to combat life-threatening viruses. Recognizing that traditional vaccines often fail to provide adequate protection against evolving viral threats, Calder employs its proprietary 3D-Vaxlock technology, which utilizes structure-based design to enhance the stability and efficacy of vaccine candidates. This innovative platform creates molecular staples that maintain vaccines in their most effective configurations, addressing the common shortcomings of subunit vaccines, such as limited potency and shelf-life. Calder's current projects include a universal flu vaccine aimed at covering all seasonal strains and a respiratory syncytial virus (RSV) vaccine tailored for the elderly. By prioritizing the development of vaccines with exceptional safety, efficacy, and durability, Calder aims to reduce severe disease and mortality rates while alleviating the burden on healthcare systems, ultimately contributing to healthier lives for vulnerable populations.

BryoSphere is a company specializing in the manufacturing of specialty chemicals, employing moss plants and biotechnology methods in the production of their goods. The company is currently focused on the development of two key products: one for addressing skin hyperpigmentation in topical treatments, and another as an anti-cancer drug.

Xias Bio is a biotechnology startup focused on the development and production of recombinant proteins. The company specializes in creating non-immunogenic natural motifs that enhance the delivery of functionalities for various applications in research, beauty, and healthcare. Xias Bio's innovative platform provides a versatile, animal product-free biomaterial that offers tailored biological functionality. This approach enables pharmaceutical and cosmetic companies to access designer proteins that serve as non-immunogenic, non-toxic alternatives to traditional synthetic and animal-derived materials. By improving attributes such as gel and film formation, as well as antioxidant properties, Xias Bio addresses the limitations of conventional solutions, positioning itself as a valuable partner in the biotechnology sector.

Producer of plant-based protein intended to decarbonize supply chains by creating valuable products from underutilized waste from other industries. The company offers a sustainable plant-based protein that is produced from spent grains by transforming the unused part of the grain from beer manufacturing into functional vegan protein, enabling clients to get products that replace the need for soy and pea protein in meat and dairy replacements

Veloz Bio is a biotechnology company founded in 2021 and based in Monterrey, Nuevo León. The company specializes in molecular farming to develop and manufacture animal-free and alternative proteins. Utilizing a rapid protein production system, Veloz Bio leverages efficient plant metabolism to create sustainable and affordable protein solutions. This innovative approach enables the company to support biotechnology firms by providing expertise in key areas such as protein production, supercritical fluid extraction, and membrane purification. Through its focus on scalable protein development, Veloz Bio aims to contribute to the advancement of alternative protein sources in the food industry.

QuantumCyte, Inc. is a technology platform company focused on advancing cancer treatment and drug efficacy prediction through innovative cell analysis systems. Established in 2014 and headquartered in Sunnyvale, California, QuantumCyte develops automated microdissection solutions that utilize digital tissue maps to pinpoint regions of interest containing critical biomarkers for treatment decisions. By leveraging artificial intelligence in its digital pathology and molecular analysis technologies, the company provides healthcare providers with precise cellular data, enabling in-depth single-cell analysis that enhances understanding of immune system and cancer biology. Through its efforts, QuantumCyte aims to improve cancer outcomes and contribute to more effective therapeutic interventions.

CroBio Ltd is an agricultural biotechnology company that focuses on developing innovative solutions to enhance water retention in soil, particularly in the face of global agricultural drought. Founded in 2019 and based in Macclesfield, United Kingdom, the company specializes in genetically engineered root-associated bacteria that create a self-sustaining, biologically active material capable of improving soil health. By harnessing expertise in microbiology and engineering, CroBio aims to provide environmentally sustainable solutions that address the challenges of water scarcity in agriculture.

Cell BioEngines, Inc. is a clinical-stage biotechnology company dedicated to the development of allogeneic "off-the-shelf" stem cell therapies aimed at treating various human diseases. The company employs a unique blood stem cell-derived epigenetic platform designed to enhance donor source availability, improve cellular potency, and simplify the manufacturing processes of clinical-grade cell products. In addition, Cell BioEngines is advancing a pre-clinical stage immunotherapy platform focused on making all cancers treatable, thereby offering the potential for long-lasting benefits in oncology. Through its innovative approach, Cell BioEngines seeks to address significant challenges in the field of cell-based therapies and improve patient outcomes.

NuKoKo is a manufacturer that specializes in creating cocoa-free chocolate through innovative bean-to-bar processes. The company utilizes ingredients sourced from the UK and has developed patent-pending technology to produce a new type of chocolate that is healthier and more sustainable than traditional options. NuKoKo's products are characterized by low carbon emissions, low sugar content, and high protein levels, allowing consumers to enjoy chocolate while minimizing environmental impact. The focus on healthier, sustainable alternatives positions NuKoKo as a unique player in the chocolate industry, appealing to environmentally conscious consumers.

Avisa Myko Inc. is a biotechnology company based in San Francisco, California, specializing in the production of natural, water-soluble melanin through precision fermentation technology. This innovative approach allows the company to manufacture melanin at scale and at an affordable cost, making it suitable for diverse applications across various industries. Avisa Myko's melanin serves multiple purposes, including protection against ionizing radiation and use in electricity generation. Its high-purity melanin is easily redissolved, facilitating incorporation into products such as cosmetics, biomedicine, organic semiconductors, biosensors, latex products, and fabrics. The company is also developing a prototype sunscreen that utilizes melanin as an ultraviolet blocker, distinguishing itself by avoiding traditional chemical or mineral UV blockers. Through its patented technology, Avisa Myko aims to contribute to better health and environmental sustainability.

Re-Fresh Global is a company focused on advancing the circular economy in the textile industry by providing innovative solutions for managing textile waste. Utilizing a patented method, the company addresses the growing issue of textile waste through advanced waste management technologies. Re-Fresh Global initiates and implements various projects aimed at promoting circularity, offering training and fostering international collaborations. Their services include smart collection and separation techniques, as well as low-cost upcycling processes for large volumes of low-value textile waste. The company engages with its customers through phone, email, and online applications to address inquiries and support their needs.

Cereswaves is an Agri-Tech startup focused on the research, development, and manufacturing of machinery for the mining, agriculture, and construction sectors. Currently operating in stealth mode, the company aims to innovate within the agricultural technology space, providing advanced solutions to enhance efficiency and productivity in these industries. Through its specialized machinery, Cereswaves seeks to address the evolving needs of its target markets and contribute to the advancement of agricultural practices.

Transition Biomining is a technology-focused company specializing in copper ore mining. It employs data-driven methods to enhance copper extraction and mining efficiency. The company's core innovation lies in optimizing microbial communities for heap-leaching operations, aiming to boost metal recovery rates, expedite extraction, and minimize environmental impact. By harnessing the power of microbiomes, Transition Biomining provides sustainable and data-driven solutions to improve clients' extraction processes in both new and existing heap-leaching operations.

Bloomlabs provides a method to catalyze waste value by regenerating it as adaptable and appealing bio-plastics and textile fibers. It envisions a future in which outmoded, resource-intensive processes are phased out in favor of cutting-edge, sustainable, and scalable alternatives.

TippingPoint Biosciences is focused on developing innovative therapeutics that address diseases caused by defects in DNA packaging, with an emphasis on conditions such as cancer and neurodegenerative disorders. Utilizing a specialized drug discovery platform, the company aims to identify new treatment options that specifically target unique genome packaging states associated with various diseases. This approach not only facilitates the treatment of cancer but also holds potential for advancing stem cell therapies by correcting dysfunctional genome packaging. Through its research and development efforts, TippingPoint Biosciences seeks to provide effective solutions for complex medical challenges.

Carbonade is a chemical manufacturing company based in Ness Ziona, Israel, founded in 2022. The company focuses on innovative electro-chemical technology for carbon capture, utilization, and storage (CCUS), aiming to address climate change through effective CO2 reduction solutions. By leveraging renewable electricity, Carbonade develops processes that convert CO2 into valuable carbon-based products, such as fuels, plastics, and chemicals. This approach not only mitigates greenhouse gas emissions but also offers clients sustainable alternatives for their manufacturing needs, positioning Carbonade as a key player in the transition towards a more sustainable economy.

California Cultured is a food company based in Davis, California, that specializes in creating sustainable, lab-grown cocoa and coffee through advanced cellular agriculture techniques. Founded in 2020, the company focuses on producing cocoa that is less bitter and requires less sugar, while also ensuring its products are healthier for consumers. By stimulating cocoa cell growth using common food ingredients, California Cultured aims to provide high-quality cocoa products that are free from the ethical issues traditionally associated with cocoa production, such as slavery and deforestation. This innovative approach allows customers to enjoy delicious and sustainable cocoa without the environmental and social drawbacks of conventional methods.