Eli Lilly and Company

Founded in 2020 and headquartered in Boston, Massachusetts, Scorpion Therapeutics is a clinical-stage biotechnology company specializing in precision oncology. It develops targeted small-molecule drugs to treat cancer by focusing on three areas: therapies against known oncogenes, agents for currently undruggable targets, and drugs for new targets.

Aparito Limited is a health technology company based in Wrexham, United Kingdom, focused on digitizing clinical trials and enhancing drug development processes. Established in 2014, the company develops mobile applications and wearable devices that facilitate real-time patient monitoring outside of traditional healthcare settings. Its Atom5™ platform supports patient-centric clinical trials by capturing frequent patient-generated data through various methods, including video eCOAs, ePROs, wearables, and telemedicine. This innovative approach allows for continuous data collection, improving understanding of diseases and clinical trial outcomes while ensuring compliance with relevant regulations. By enabling patients and their caregivers to participate in research from home, Aparito aims to improve patient outcomes and streamline the drug development process.

Morphic Therapeutic is a biotechnology company focused on developing oral integrin therapies to treat serious chronic diseases such as autoimmune disorders, cardiovascular conditions, metabolic diseases, fibrosis, and cancer.

Point Biopharma Global Inc., established in 2019 and headquartered in Toronto, Canada, specializes in the development and commercialization of radioligand therapies for cancer treatment. The company's portfolio comprises several assets, including PNT2002, PNT2004, PNT2003, and PNT2001. Point Biopharma leverages its expertise in radioisotopes like Actinium-225 and Lutetium-177, along with advanced manufacturing technology and a patient-centric approach, to revolutionize theragnostic drug development and radioligand commercialization on a global scale.

Versanis Bio is a biopharmaceutical company focused on discovering and developing innovative medicines for medical conditions commonly affecting older adults. The company is advancing Bimagrumab, a human monoclonal antibody that targets activin type II receptors, effectively blocking ligands such as activin A and myostatin. Bimagrumab has undergone extensive clinical evaluation in over a dozen trials with more than 1,500 participants, demonstrating its ability to induce significant fat loss while preserving lean mass. Additionally, treatment with Bimagrumab has shown improvements in HbA1c levels and other cardiometabolic parameters, thereby assisting overweight and obese adults in achieving and maintaining a healthier body composition.

Emergence Therapeutics AG is a biopharmaceutical company based in Duisburg, Germany, focused on developing innovative antibody-drug conjugates (ADCs) to address high-need cancers. Established in 2019, the company leverages advanced technologies in antibody design, linker systems, and therapeutic payloads to create targeted treatments. Its lead program specifically targets Nectin-4, a clinically validated marker for various cancers, utilizing a highly specific antibody in combination with optimized linker technology and amanitin as the payload. This approach aims to provide effective therapeutic options for challenging cancer types. Emergence Therapeutics is also exploring opportunities to develop additional first- or best-in-class ADCs to meet unmet medical needs in oncology.

Sigilon Therapeutics, Inc. is a clinical-stage biopharmaceutical company based in Cambridge, Massachusetts, dedicated to developing functional cures for patients with chronic diseases. Founded in 2015, the company aims to create immune-protected, engineered human cells that restore normal physiological functions without the risk of fibrosis or immune rejection. Its lead product candidate, SIG-001, is currently in Phase I/II clinical trials for preventing bleeding episodes in patients with moderate to severe Hemophilia A. Additionally, Sigilon is advancing other candidates, including SIG-005, which targets non-neurological manifestations of mucopolysaccharidosis type 1, and SIG-002, designed to replace islet cells for treating type 1 diabetes. The company's innovative Shielded Living Therapeutics platform leverages advances in cell engineering and proprietary biocompatible materials to offer stable and durable therapeutic solutions for a variety of chronic conditions.

DICE Therapeutics is a biopharmaceutical company dedicated to developing novel oral therapeutic candidates aimed at treating chronic diseases, particularly in immunology. Utilizing its proprietary DELSCAPE technology platform, DICE focuses on creating selective oral small molecules that can effectively modulate protein-protein interactions, similar to the efficacy of existing systemic biologics. The company's lead candidate, S011806, targets interleukin-17 (IL-17), a key pro-inflammatory molecule associated with various immunological conditions. Additionally, DICE is advancing oral therapies aimed at α4ß7 integrin and αVß1/αVß6 integrin, which are intended for the treatment of inflammatory bowel disease and idiopathic pulmonary fibrosis, respectively. Through its innovative approach, DICE Therapeutics aims to bring effective oral treatments to patients suffering from chronic inflammatory diseases.

Akouos is a biotechnology company focused on precision genetic medicine to restore and preserve hearing. Based in Boston, it develops gene therapies using a proprietary adeno-associated viral vector platform and delivery approaches to treat sensorineural hearing loss in genetically defined populations. The company's lead program, AK-OTOF, targets hearing loss caused by mutations in the OTOF gene. Akouos pursues research and development across gene-based interventions aimed at improving auditory function and long-term sensory outcomes. It has collaborations with academic and industry partners, including Massachusetts Eye and Ear and Lonza, to advance discovery and manufacturing capabilities. Founded in 2016, Akouos addresses unmet clinical needs in auditory health by seeking to restore physiologic hearing through targeted genetic therapies.

Protomer Technologies Inc. is a pre-clinical stage biotechnology company based in Pasadena, California, founded in 2014. The company specializes in the development of therapeutic proteins and peptides through its proprietary platform known as Molecular Engineering of Protein Sensors (MEPS). This innovative platform allows for the creation of proteins that can sense molecular activators in the body and be activated as needed, facilitating variable dosing and targeted delivery. Protomer's research primarily focuses on metabolic diseases, with a notable product being a glucose-responsive insulin designed to help manage rising sugar levels in individuals with diabetes. Through its advanced protein-engineering capabilities, Protomer Technologies aims to enhance treatment options for patients suffering from metabolic conditions.

Prevail Therapeutics Inc. is a biotechnology company headquartered in New York, specializing in the development and commercialization of gene therapies targeting neurodegenerative diseases. Founded in 2017, the company focuses on adeno-associated virus (AAV)-based therapies, with its lead candidate, PR001, currently undergoing Phase I/II clinical trials for Parkinson's disease associated with GBA1 mutations and neuronopathic Gaucher disease. Additionally, Prevail is advancing PR006 for frontotemporal dementia linked to GRN mutations and PR004 for various synucleinopathies. The company's mission is to provide disease-modifying treatments for patients suffering from these challenging conditions.

Disarm Therapeutics, Inc. is a biotechnology company founded in 2016 and headquartered in Cambridge, Massachusetts. The company focuses on developing disease-modifying therapeutics aimed at treating neurological diseases characterized by axonal degeneration. Its innovative drugs are designed to prevent the loss of axons, offering potential treatments for conditions such as multiple sclerosis, amyotrophic lateral sclerosis, glaucoma, and peripheral neuropathies. Disarm Therapeutics aims to provide effective therapies for patients suffering from acute diseases affecting the central, ocular, and peripheral nervous systems. As of late 2020, Disarm Therapeutics operates as a subsidiary of Eli Lilly and Company.

Dermira, Inc. is a biopharmaceutical company that specializes in developing and commercializing therapies for dermatologic diseases, primarily targeting the U.S. market. Founded in 2010 and headquartered in Menlo Park, California, Dermira offers QBREXZA, a topical treatment for primary axillary hyperhidrosis in patients aged nine and older. The company is also advancing its pipeline with lebrikizumab, a monoclonal antibody currently in Phase IIb trials for moderate-to-severe atopic dermatitis, alongside several other early-stage research initiatives in dermatology. Dermira has established strategic partnerships for the development and commercialization of its products, including agreements with Maruho Co., Ltd., F. Hoffmann-La Roche Ltd, Genentech, Inc., and UCB Pharma S.A. Notably, Dermira was previously known as Skintelligence, Inc. before rebranding in September 2011. As of early 2020, Dermira operates as a subsidiary of Eli Lilly and Company.

Loxo Oncology, Inc. is a biopharmaceutical company based in Stamford, Connecticut, focused on developing and commercializing targeted therapies for genetically defined cancers in the United States. Founded in 2013, the company aims to bring innovative cancer treatments to the clinic by identifying actionable "driver mutations" in tumors. Its lead product candidate, larotrectinib, is an oral selective inhibitor of tropomyosin receptor kinase (TRK) and is undergoing various clinical trials for multiple cancer types, including lung, melanoma, and breast cancer. Loxo Oncology is also advancing several preclinical programs, including candidates targeting RET fusion proteins and FGFR isoforms. The company has established collaborations with several organizations to enhance its drug discovery efforts and optimize its clinical development strategies. As a subsidiary of Eli Lilly and Company, Loxo Oncology is dedicated to creating effective therapies that address specific genetic vulnerabilities in cancer patients.

AurKa Pharma is a biopharmaceutical company focused on developing a single compound aimed at treating solid tumors. The company has completed GLP toxicology studies for its drug candidate and is preparing to initiate clinical development. Once it receives the necessary regulatory approvals, the compound will be tested in clinical settings to determine its efficacy in treating solid tumors. AurKa Pharma intends to explore additional cancer indications after establishing proof-of-concept, ultimately aiming to enhance treatment options for cancer patients.

CoLucid Pharmaceuticals, Inc. is a biotechnology company dedicated to developing therapies for central nervous system disorders. The company focuses on innovative treatments for migraine headaches and other neurological conditions. It is advancing COL-144, a neurally acting anti-migraine agent aimed at effectively treating migraines. Additionally, CoLucid is working on COL-204, a conjugated stigmine platform that generates new chemical entities for addressing a range of conditions, including sleep/wake disorders, chronic pain, Alzheimer's disease, and psychiatric disorders. Established in 2005, CoLucid Pharmaceuticals is headquartered in Research Triangle Park, North Carolina.

Novartis is a global healthcare company based in Switzerland, providing innovative medicines and solutions to address evolving patient needs worldwide. With over 100,000 employees across 140 countries, they focus on discovering new treatments in areas such as oncology, immunology, neuroscience, and cardiovascular diseases.

Lohmann is a manufacturer of feed additives and poultry vaccines, selling its products in over 80 countries around the world. Headquartered in Cuxhaven, Germany, Lohmann has a production facility there, a vaccine plant in Winslow, Maine, and is represented by 18 subsidiaries in Europe, Asia and North America. The focus of Lohmann is the development of vaccines and food components that help prevent diseases of animals used in food production.

ChemGen Corp. is a privately held bioscience company focused on developing and commercializing innovative feed enzyme products. The company specializes in enhancing the efficiency of poultry, egg, and meat production through its advanced enzyme solutions. By leveraging scientific research and technology, ChemGen aims to improve animal nutrition and overall production outcomes in the agricultural sector.

Avid Radiopharmaceuticals is a Philadelphia-based company focused on the development of molecular imaging agents designed to enhance the medical management of chronic diseases. Its mission centers on creating innovative imaging compounds that facilitate the early identification of pathological changes, thereby supporting earlier diagnosis and improved management of various conditions. Avid's notable product, Amyvid, is an imaging tool utilized in positron emission tomography to detect beta-amyloid plaques in the brain, which plays a crucial role in the assessment of Alzheimer's disease. Through its advancements in molecular imaging, Avid aims to contribute to the development of new therapies and improve clinical outcomes for patients suffering from significant chronic illnesses.

Alnara Pharmaceuticals, Inc. specializes in the development of novel protein therapeutics aimed at treating metabolic diseases. The company employs an innovative strategy that emphasizes the creation of effective protein therapies capable of being delivered orally to the gastrointestinal tract, ensuring they are not absorbed into the bloodstream. This unique approach positions Alnara at the forefront of therapeutic advancements for metabolic conditions, leveraging the potential of protein-based treatments to improve patient outcomes.

ImClone Systems is a prominent biotechnology company focused on the development and manufacture of therapeutic products aimed at improving oncology care. Established in 1984, the company specializes in creating targeted biologic treatments for various cancers, leveraging advancements in molecular biology, genomics, and antibody engineering. Its flagship product, ERBITUX, is complemented by a diverse pipeline of investigational monoclonal antibodies currently in mid- to late-stage clinical development, targeting major solid tumor types. Following its acquisition by Eli Lilly and Company in 2008, ImClone has enhanced its pipeline development through Lilly's global resources. The company operates state-of-the-art FDA-approved manufacturing facilities in Branchburg, New Jersey, which are among the largest for biologic manufacturing worldwide. Additionally, ImClone has research headquarters in New York City and maintains international operations in Europe, positioning it well to meet the evolving medical needs of cancer patients.

As of August 20, 2008, SGX Pharmaceuticals, Inc. was acquired by Eli Lilly & Co. SGX Pharmaceuticals, Inc., a biotechnology company, focuses on the discovery, development, and commercialization of therapeutics for addressing unmet medical needs in oncology. The company's product pipeline includes drug candidates from its FAST drug discovery platform, which uses X-ray crystallography and complementary biophysical and biochemical methods, combined with medicinal and computational chemistry. Its drug development programs target the c-MET receptor tyrosine kinase (MET), an enzyme implicated in an array of cancers; and the BCR-ABL tyrosine kinase enzyme for the treatment of chronic myelogenous leukemia (CML), a bone marrow cancer. Under the MET development program, the company develops SGX523, which is in Phase I clinical development studies for solid tumor indications; and SGX126, a preclinical development product for solid tumors indications. Under the BCR-ABL Development Program, SGX Pharmaceuticals develops SGX393, an oral therapy for the second-line treatment of CML, which is in preclinical development studies. Its drug discovery technologies are also applied to a portfolio of oncology targets, including JAK2, a non-receptor tyrosine kinase involved in cytokine-induced signaling and growth regulation, survival, and differentiation of cells; RAS, a protein that regulates cell growth; and three other tyrosine kinases. The company has a license and collaboration agreement with Novartis Institutes for Biomedical Research, Inc., Cystic Fibrosis Foundation Therapeutics, Inc., National Institutes of Health, and Eli Lilly & Company. SGX Pharmaceuticals, formerly known as Structural GenomiX, Inc., was founded in 1998 and is headquartered in San Diego, California.

A privately held applied research and pharmaceutical product development company focused on the animal health industry.

Hypnion is a neuroscience drug discovery and development company based in Worcester, Massachusetts, founded in 2000. The company specializes in creating innovative therapeutics for central nervous system disorders, particularly focusing on sleep and wake-alertness disorders, as well as circadian rhythm abnormalities. Hypnion utilizes its proprietary drug discovery platform, SCORE-2004, which measures the effects of drugs on sleep and wake parameters. This unique system enables the company to advance its research and development efforts effectively. In recognition of its innovative approach and contributions to the field, Hypnion was acquired by Eli Lilly and Company.

ICOS Corporation is a biotechnology company that engages in the discovery, development, and commercialization of therapeutic products. It is engaged in the commercialization of treatments for unmet medical conditions, such as benign prostatic hyperplasia, hypertension, pulmonary arterial hypertension, cancer, and inflammatory diseases. It is the developer of a treatment known as Cialis (tadalafil), a product for the treatment of erectile dysfunction through its joint venture with Eli Lilly and Company in North America and Europe. It is also engaged in contract manufacturing services for third parties. It is in a strategic alliance with Solvay Pharmaceuticals, Inc. ICOS Corporation was established in 1989, based in Bothell, Washington. It is currently operated by Eli Lilly and Company.

Applied Molecular Evolution, Inc. discovers, optimizes, and develops human bio-therapeutics. Applied Molecular Evolution offers AMEsystem technology platform for the development of human biotherapeutic candidates.

Pharmaserve-Lilly S.A.C.I provides researches, distributes, and commercializes pharmaceutical products in Greece.

Origin Medsystems is a medical device manufacturing company. It manufactures and markets invasive laparoscopic surgical devices. The company was founded by Jay Watkins in 1998 and is headquartered in Santa Clara, California.

Heart Rhythm Technologies, Inc offers health care services including cardiovascular services.

Pacific Biotech develops and markets diagnostic tests for detection of pregnancy, infectious diseases, strep throat, and mononucleosis.

Devices for Vascular Intervention operates as a developer of catheters for coronary atherectomy.

Hybritech is a San Diego-based medical research company develops and markets monoclonal antibodies which are used in making diagnostic and medical monitoring tests to identify a variety of infectious, viral, and cancer-related diseases including colon and prostate cancer, infertility, allergies, and pregnancy.

Advanced Cardiovascular Systems, Inc. develops and manufactures cardiovascular medical products. It operates as a subsidiary of Abbott Laboratories. Its medical devices help patients with heart diseases in returning to active and productive lives and physicians for improving patient management and clinical outcomes. Advanced Cardiovascular Systems, Inc. is based in Santa Clara, California. it is currently known as Abbott Cardiovascular Systems.

Physio-Control, Inc. specializes in emergency medical response products and services, with a strong reputation for its LIFEPAK defibrillators, which are widely recognized by first responders and healthcare professionals. The company focuses on developing advanced technologies and designing high-quality devices that meet the needs of both clinical care providers and everyday citizens. In addition to defibrillators, Physio-Control offers chest compression systems and cloud-based data management solutions, establishing itself as a leader in the industry. Its commitment to customer-driven product development has set a benchmark for quality and reliability in emergency medical equipment.