DCVC

DCVC is a venture capital firm based in Palo Alto, California, founded in 2010. The firm specializes in investing in seed and early-stage companies across various sectors, including artificial intelligence, exascale computing, climate technology, engineering, materials science, robotics, space, water, biology, defense, and security. With a team of experienced venture capitalists, technology entrepreneurs, and engineers, DCVC has a proven track record, having invested in over 150 companies and achieved 40 significant exits. In 2018, the firm expanded its focus with the launch of DCVC Bio, which invests in early-stage startups in computational biology. This branch targets innovations in synthetic biology, medicine, and agriculture, emphasizing teams that leverage advancements in genetic sequencing, artificial intelligence, and automation to drive transformative changes in the life sciences. Both divisions of DCVC are committed to supporting entrepreneurs who are advancing technology and creating impactful solutions in their respective fields.

Zachary Bogue

Co-Founder and Managing Partner

Chris Boshuizen

Operating Partner

Jack Buendorf

Associate

Kelly Chen

Partner

Alan Cohen

General Partner

Michael Driscoll Ph.D

Founding Partner

Anna Fokina

Investment Director

John Hamer

Managing Partner

MayC Huang

Investor

Gloria Lau

Equity Partner

Patrick Mccauley

Operating Partner

Matt O'Connell

Operating Partner

Matthew Ocko

Co-Managing Partner and Co-Founder

Joe Oleynik

Associate

Luca Parolari

Senior Associate, DCVC Bio

Jason Pontin

Partner

Spencer Punter

Partner, COO

Kristen Rocca

Principal

Monica Rogati

Equity Partner

Merline Saintil

Operating Partner

Richard Waines

Associate, DCVC Bio

Past deals in California

Auradine

Series A in 2023
Auradinescalability, sustainability and security solutions for the infrastructure, enabled by revolutionary blockchain, security, zero-knowledge and AI technologies.

Twelve

Series B in 2022
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Capella Space

Series C in 2022
Capella Space is a San Francisco-based company specializing in commercial radar satellite technology. It operates a constellation of small satellites that utilize synthetic aperture radar to capture high-resolution images of the Earth's surface, achieving clarity even in challenging conditions such as clouds, smoke, and darkness. The imagery provided is sub-meter in resolution and serves various industries, including defense, disaster response, agriculture, and infrastructure monitoring. By offering timely and flexible access to critical geospatial information, Capella Space enhances decision-making related to commerce, conservation, and public safety. Founded in 2014, the company aims to make Earth observation an integral tool for understanding and addressing the dynamic changes occurring globally.

Unlearn

Series B in 2022
Unlearn is a San Francisco-based company founded in 2017 that specializes in using artificial intelligence to enhance clinical research. It develops innovative software tools aimed at improving clinical trial design, including the creation of Digital Twins to generate Intelligent Control Arms. By utilizing historical datasets and disease-specific machine-learning models, Unlearn produces virtual placebo patients derived from actual patient baseline data, which helps to increase trial power, accelerate timelines, and provide patient-level insights. This approach reduces or eliminates the need for concurrent control arms in clinical studies, streamlining the research process. Unlearn has garnered significant attention, securing $20 million in funding and collaborating with leading pharmaceutical companies. Its work has been recognized in prestigious publications, including a peer-reviewed article in Nature, and it has been acknowledged as a key player in digital health innovation. The company continues to engage with regulators and industry leaders to drive advancements in clinical research through the application of AI technologies.

Brimstone

Series A in 2022
Brimstone Energy is a hardware cleantech startup that aims to reduce CO2 emissions through innovative technologies.

Creyon

Series A in 2022
Creyon Bio is a pre-clinical stage company focused on advancing drug development through a data-driven methodology. It specializes in engineering RNA-based medicines and their components by creating proprietary datasets that inform advanced machine learning models. This innovative approach enables the rapid identification of design rules and engineering principles necessary for the development of safe and effective oligonucleotide-based medicines. By leveraging these insights, Creyon Bio aims to improve the efficiency of the drug development process, ultimately contributing to cost savings in the healthcare sector while catering to diverse patient populations.

Petra

Series A in 2021
Petra is a Robotics company that focuses solely on underground utilities. Petra enables undergrounding critical utilities by boring utility tunnels through previously impenetrable geologies.

Gradle Inc.

Series C in 2021
Gradle, Inc. is a developer of open-source build automation software that aims to transform the software development process. The Gradle Build Tool is widely recognized as the most popular build tool for open-source JVM projects, averaging over 19 million downloads monthly and being utilized by notable projects such as Spring Boot and JUnit. Gradle Enterprise complements this by providing a software build performance acceleration and analytics platform, designed to enhance productivity for software development teams. This self-hosted solution utilizes advanced acceleration technologies to reduce build times significantly and employs data analytics for efficient troubleshooting. Gradle Enterprise supports the discipline of Developer Productivity Engineering, enhancing the build and test processes within both Gradle and Maven environments. By unifying and automating build processes, Gradle, Inc. enables enterprises to improve their software delivery capabilities effectively.

Kettle

Series A in 2021
Kettle Inc. is an innovative company based in Kensington, California, specializing in online risk analysis for the insurance industry. Founded in 2020, Kettle develops a machine-learning powered platform that utilizes deep learning algorithms to analyze over seven billion lines of satellite, weather, and ground truth data. By employing Swarm Neural Networks, the platform identifies patterns that enhance the accuracy of risk predictions related to climate change, thereby assisting insurers in managing catastrophic risks. Kettle's approach aims to improve underwriting processes and reduce loss ratios, enabling the sale of reinsurance to other insurers while effectively balancing risk in an evolving climate landscape.

Jupiter Intelligence

Series C in 2021
Jupiter Intelligence, Inc. specializes in developing tools and platforms that provide comprehensive weather and climate data, trend visualizations, forecasts, and risk assessments. The company offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate multiple prediction models based on data from millions of ground-based and satellite sensors. Additionally, Jupiter provides FloodScore and HeatScore services, which help users prepare for flooding and mitigate temperature-related impacts from climate change, respectively. These services focus on climate risk assessment and management in urban regions such as New York City, South Florida, and the Atlantic Coast, with plans for global expansion. Jupiter's models are informed by the latest scientific research from the global Earth and Ocean Systems community. Founded in 2017 and based in San Mateo, California, Jupiter Intelligence was previously known as Jupiter Technology Systems, Inc. before rebranding in December 2017.

Kentik

Series C in 2021
Kentik Technologies, Inc. is a network intelligence platform that delivers cloud-based real-time visibility and analytics solutions for network and security operators. Founded in 2014 and headquartered in San Francisco, California, the company offers Kentik Detect, a big data-based software-as-a-service that transforms network data into actionable intelligence. This platform enables clients to conduct ad-hoc analytics for improved operations, capacity optimization, anomaly resolution, and DDoS detection, thereby enhancing application and service protection. Kentik also provides My Kentik, a self-service network analytics tool, and an AIOps platform aimed at streamlining network operations. Additionally, the company serves various industries, including financial services, media and entertainment, cloud infrastructure, and telecommunications, offering tailored solutions for visibility, performance, detection, planning, and integration. Kentik was previously known as CloudHelix, Inc. before rebranding in September 2014.

CH4 Global

Series A in 2021
CH4 Global Inc. is a holding company based in San Francisco, California, that specializes in producing seaweed bio-products aimed at reducing methane emissions from livestock. Founded in 2019, the company focuses on Asparagopsis armata, a seaweed supplement that has been scientifically proven to decrease methane emissions from ruminant animals such as cows, goats, sheep, and deer by up to 90%. By leveraging advanced aquaculture techniques, CH4 Global provides innovative solutions to mitigate greenhouse gases on a global scale, with its products offered through subsidiaries in the United States, Australia, New Zealand, and the Pacific. The company has attracted investment from family offices and private investors, as well as support from government organizations, to further its mission of addressing climate change while providing benefits like carbon credits for farmers and food producers.

CodeSee

Seed Round in 2021
CodeSee is a developer of cloud-based data visualization software that facilitates a comprehensive understanding of code for developers and development teams. By analyzing the data flowing through a system, CodeSee creates an updated map of the system architecture, its components, and their interconnections. This allows developers to explore their codebase at both a high level and in detail, enhancing their ability to grasp how code and functionality relate to one another. The platform aims to transform developers from feeling like outsiders to becoming high performers, thereby expediting the development process and improving overall productivity.

Genedit

Series A in 2021
GenEdit Inc. is a biotechnology company based in Berkeley, California, established in 2016. It specializes in developing innovative genome editing technologies, particularly using the CRISPR/Cas9 system for therapeutic gene editing. The company focuses on addressing the challenges associated with the delivery of gene therapies through its proprietary non-viral nanoparticle-based delivery platform. This platform enables more efficient and accurate delivery of CRISPR components, enhancing the potential for curative treatments for genetic diseases. By systematically screening a library of nanoparticles, GenEdit aims to improve the safety and effectiveness of gene editing, making it a promising solution for a wide range of therapeutic applications.

Insight M

Series C in 2021
Kairos Aerospace provides large-scale, aerial monitoring of methane emissions. The company completed the first-ever basin-wide aerial survey for methane detection in its 2019 survey of the Permian Basin. Kairos Aerospace’s mission is to improve operational excellence for the oil and gas industry with cost-effective, efficient methane reductions at scale.

Earth AI

Seed Round in 2021
Earth AI Pty Ltd. is an innovative mineral exploration company based in Parramatta, Australia, founded in 2016. The company specializes in developing artificial intelligence-based software that identifies potential areas of mineralization in remote locations lacking pre-existing geological data. By using AI mineral targeting technology, Earth AI provides geologists with location suggestions for mineral exposure and automatically generates detailed geological maps from satellite, geophysical, and geochemical datasets. This approach allows Earth AI to discover new metal deposits valued between $10 million and $100 million significantly faster and at a lower cost than traditional methods. The company's field-proven system is reported to be 50 times more successful in identifying mineralized prospects and achieves five times cheaper field operations through hardware automation and streamlined processes. Earth AI focuses on various metals, including copper, lead, zinc, nickel, cobalt, vanadium, and rare earth elements, effectively enhancing the chances of successful mineral discovery while minimizing operational risks and expenses.

Frontier Medicines

Series B in 2021
Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company specializes in discovering and developing medicines that target cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational techniques and machine learning to identify new binding pockets on proteins, thereby facilitating the discovery and development of small-molecule drugs. By enhancing the drug development process, Frontier Medicines aims to deliver breakthrough therapies that can significantly change the treatment landscape for debilitating diseases.

Pivot Bio

Series D in 2021
Pivot Bio is a biotechnology company founded in 2010 and based in Emeryville, California, that focuses on enhancing crop nutrition through the use of engineered microbes. The company leverages its deep understanding of the plant microbiome, employing engineering principles and data science to map microbial dynamics and develop beneficial traits. Pivot Bio's proprietary ON Technology utilizes naturally occurring microbes to provide crops with essential nutrients, particularly nitrogen, which is crucial for growth. This innovative approach aims to replace synthetic nitrogen fertilizers, thereby reducing the environmental impact associated with conventional farming practices. By enhancing crops' ability to capture and metabolize atmospheric nitrogen, Pivot Bio seeks to lower farming costs, improve crop yields, and contribute to a sustainable agricultural future that benefits both the planet and food supply.

Stemson Therapeutics

Series A in 2021
Stemson Therapeutics, LLC operates as a cell therapy company that helps to restore natural hair. The company produces cells required to regenerate hair follicles using the novel cell engineering process. Its products include the stemson solution, a solution that generates novo follicles using induced pluripotent stem cells (iPSC) to grow new Dermal Papilla. The company was founded in 2018 and is based in LA Jolla, California.

Twelve

Series A in 2021
Twelve, formerly known as Opus 12, is a Berkeley, California-based company that specializes in recycling carbon dioxide emissions into valuable chemicals and fuels. Founded in 2015, the company has developed innovative technology that can be integrated with any source of CO₂ emissions. By utilizing only water and electricity as inputs, Twelve transforms captured carbon dioxide into essential products such as methane, ethylene, and ethanol. The firm aims to provide a cost-competitive alternative to petroleum-derived chemicals and fuels, thereby addressing carbon emissions while simultaneously creating economically viable solutions.

Primer

Series C in 2021
Primer Technologies, Inc. specializes in developing advanced software that employs machine learning and natural language processing to analyze extensive datasets. The company's platform is designed to read and interpret documents in multiple languages, uncover insights, and generate automated reports that rival human analysis. By facilitating the understanding of vast amounts of text data, Primer assists governments and corporations in monitoring and making sense of global information. Founded in 2015 and headquartered in San Francisco, California, Primer aims to bridge the intelligence gap for businesses and enhance their ability to respond to emerging trends in the world.

Strateos

Series B in 2021
Strateos operates a robotic cloud laboratory that automates chemistry, biology, and tissue analysis to enhance drug discovery processes. By integrating advanced robotics, control systems, and sophisticated imaging and analytics software, Strateos allows pharmaceutical companies to discover new drug candidates more efficiently. The company emerged from a merger between Transcriptic, known for its pioneering robotic cloud laboratory platform, and 3Scan, which specialized in using automation and machine learning to analyze tissue samples. This combination enables Strateos to provide a comprehensive suite of technologies designed to streamline the drug discovery and early development phases. By transforming life science methodologies into data-driven processes, Strateos aims to create a more efficient and cost-effective approach to scientific research, positioning itself as a valuable partner to biotechnology firms seeking to innovate in the field.

Pano

Seed Round in 2021
Developer of a wildfire detection and intelligence platform intended to quickly mitigate wildfire threats. The company's platform uses artificial intelligence applied to proprietary mountaintop camera feeds and satellite imagery to detect threats in real-time from a monitoring system for confirmation and rapid dissemination of critical information, enabling government agencies, utilities, and private landowners to take action to protect lives, property, and the environment.

Plexium

Series A in 2021
Plexium, Inc. is a biotechnology company based in San Diego, California, established in 2017. The company specializes in drug development, focusing on the identification of small molecules that modulate E3 ligases for therapeutic applications in cancer and neurodegenerative diseases. Plexium employs a DNA-encoded library platform to conduct high-throughput screening, utilizing cell-based assays to discover molecular glues that can alter E3 ligase substrate recognition, thereby inducing, inhibiting, or modulating protein degradation. This innovative approach allows Plexium to selectively target various cancers, including small cell lung and breast tumors, while also exploring mechanisms to enhance immune responses through E3 ligase modulation.

Deepcell

Series A in 2020
Deepcell, Inc. is a company based in Mountain View, California, focused on advancing diagnostic technologies through a non-invasive approach. Founded in 2015, it has developed a microfluidic imaging platform that leverages artificial intelligence to classify cells by their visual features. This technology allows for the isolation of viable cells based on their morphological characteristics, facilitating detailed genetic health assessments from standard blood samples. By enabling insights at the single-cell level, Deepcell aims to improve the diagnosis and treatment of various diseases, offering researchers a valuable alternative to invasive diagnostic methods.

Subtle Medical

Series A in 2020
Subtle Medical, Inc., a healthcare technology company, develops medical imaging software for clinical imaging centers and hospitals. Its product includes SubtleMR, an artificial intelligence-based image processing software that reduces image noise and increases image sharpness for non-contrast enhanced magnetic resonance imaging (MRI). It enables to reduce cost, imaging time, and radiation/contrast dose. The company was founded in 2017 and is based in Menlo Park, California.

MycoWorks

Series B in 2020
MycoWorks LLC specializes in the research, design, and manufacturing of sustainable leather alternatives derived from natural mycelium. Established in 2013 and based in San Francisco, the company produces a proprietary material called Reishi, which is water-resistant and customizable in texture and features. Reishi is designed to mimic the performance and feel of traditional leather while being animal-free and environmentally friendly. MycoWorks employs a unique platform known as Fine Mycelium to create this innovative biomaterial, which boasts qualities such as strength, durability, and biodegradability. The company aims to provide natural alternatives to conventional materials like plastic foams, textiles, and leather, catering to industries such as aerospace, automotive, apparel, and architectural interiors. Through its carbon-negative production process, MycoWorks offers a rapidly grown solution that aligns with sustainable design principles.

Carbon Health

Series C in 2020
Carbon Health is a tech-enabled healthcare company founded in 2015 and headquartered in San Francisco, California. It provides a mobile application that facilitates primary care services, allowing users to manage their treatment plans, prescriptions, and lab reports in one place. The company offers omnichannel care through various access points, including clinics, pop-up sites, video consultations, and its application, ensuring convenient and accessible healthcare for patients. Additionally, Carbon Health developed a coronavirus assessment tool and has established COVID-19 testing sites in California, further enhancing its commitment to delivering comprehensive healthcare services.

Unlearn

Series A in 2020
Unlearn is a San Francisco-based company founded in 2017 that specializes in using artificial intelligence to enhance clinical research. It develops innovative software tools aimed at improving clinical trial design, including the creation of Digital Twins to generate Intelligent Control Arms. By utilizing historical datasets and disease-specific machine-learning models, Unlearn produces virtual placebo patients derived from actual patient baseline data, which helps to increase trial power, accelerate timelines, and provide patient-level insights. This approach reduces or eliminates the need for concurrent control arms in clinical studies, streamlining the research process. Unlearn has garnered significant attention, securing $20 million in funding and collaborating with leading pharmaceutical companies. Its work has been recognized in prestigious publications, including a peer-reviewed article in Nature, and it has been acknowledged as a key player in digital health innovation. The company continues to engage with regulators and industry leaders to drive advancements in clinical research through the application of AI technologies.

Golden

Series A in 2020
Golden is a developer of a self-constructing knowledge database used to accelerate discovery and education. The company uses and leverages human effort by using machine intelligence to make the process of gathering and communicating knowledge simpler. It combines a powerful search across several entities with fine-grain alerts to stay on top of changes, and semi-automatic research assistance for gaps in knowledge that enable people in organizations to stay current, understand and leverage the latest trends in their industry.

Curative

Seed Round in 2020
Curative is a healthcare provider focused on enhancing access to essential medical services. The company specializes in COVID-19 testing, offering a 24-hour service that utilizes a more efficient and precise oral fluid test, thereby alleviating strain on medical supply chains and healthcare workers. In addition to testing, Curative provides a range of services including vaccinations, baseline health visits, and virtual urgent care, all designed to facilitate easier access to healthcare for individuals. This commitment to improving healthcare accessibility positions Curative as a significant player in the health insurance sector, catering to the needs of diverse communities.

Zymergen

Series D in 2020
Zymergen, Inc. is a biotechnology company that focuses on researching, developing, and manufacturing microbes for various industries, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. The company integrates automation, machine learning, and genomics to enhance its platform, which aids in optimizing microbial strains and improving the efficiency of production processes. By leveraging big data and artificial intelligence, Zymergen collaborates with clients to engineer novel molecules from microbes, thereby advancing product development. Founded in 2013 and headquartered in Emeryville, California, Zymergen also has offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan, enabling it to serve a global clientele effectively.

Auransa

Series A in 2020
Auransa is an AI-driven platform for discovering drugs of novel pharmacology from vast amounts of genomics data collected from human disease tissues. The company's platform is used to study molecular disease subtypes and predict compounds and targets for responder patient population. Current internal drug pipeline includes cancer and other diseases. The company has partnership with companies and institutions in biopharma industry.

Atomwise

Series B in 2020
Atomwise, Inc. specializes in deep learning artificial intelligence technology aimed at small molecule drug discovery. The company leverages its proprietary AI platform, AtomNet, which contains over 16 billion molecules for virtual screening, to enhance the speed and accuracy of drug discovery processes. This technology employs a statistical approach to predict the binding of small molecules to proteins, aiding in drug hit discovery, binding affinity prediction, and toxicity detection. Atomwise collaborates on numerous projects each year with major pharmaceutical and agrochemical companies, as well as over 200 universities and hospitals across 40 countries. Founded in 2012 and based in San Francisco, Atomwise was previously known as Chematria, Inc. before rebranding in 2015.

Atomwise

Series B in 2020
Atomwise, Inc. specializes in deep learning artificial intelligence technology aimed at small molecule drug discovery. The company leverages its proprietary AI platform, AtomNet, which contains over 16 billion molecules for virtual screening, to enhance the speed and accuracy of drug discovery processes. This technology employs a statistical approach to predict the binding of small molecules to proteins, aiding in drug hit discovery, binding affinity prediction, and toxicity detection. Atomwise collaborates on numerous projects each year with major pharmaceutical and agrochemical companies, as well as over 200 universities and hospitals across 40 countries. Founded in 2012 and based in San Francisco, Atomwise was previously known as Chematria, Inc. before rebranding in 2015.

Rigetti Computing

Series C in 2020
Rigetti Computing is a full-stack quantum computing company based in Berkeley, California, with an additional office in Fremont. Founded in 2013, it designs and manufactures quantum integrated circuits and superconducting quantum processors. The company packages and deploys these chips in low-temperature environments and develops accompanying control systems to perform quantum logic operations. Rigetti also offers a cloud services platform, Quantum, which facilitates the integration of its quantum machines into various cloud environments. Additionally, it provides Forest, a programming and execution environment that supports the development of quantum applications. With a focus on near-term applications in computational chemistry and machine learning, Rigetti aims to advance practical quantum computing through its proprietary technology and infrastructure, which enables seamless integration with both public and private cloud systems. The majority of its revenue is generated in the United States.

Caption Health

Series B in 2020
Caption Health, Inc. develops artificial intelligence-based software solutions designed to assist healthcare providers in acquiring and interpreting ultrasound exams. The company's flagship product, Caption AI, offers real-time guidance for performing echocardiography, enabling practitioners to capture diagnostic-quality images, automate quality assessments, and interpret ultrasound results effectively. Founded in 2013 and headquartered in Brisbane, California, Caption Health was previously known as Bay Labs, Inc. The company focuses on enhancing the capabilities of ultrasound technology through innovative software, ultimately aiming to improve patient outcomes in medical imaging.

Orca Bio

Series D in 2020
Orca Bio is a clinical-stage cell therapy company dedicated to delivering curative medicine to these patients. Orca Bio has developed a pipeline of proprietary technologies that have the potential to impact over 100 malignant and auto-immune diseases. Orca has assembled a team of world-leading experts and technologists to execute this vision.

Orca Bio

Series D in 2020
Orca Bio is a clinical-stage cell therapy company dedicated to delivering curative medicine to these patients. Orca Bio has developed a pipeline of proprietary technologies that have the potential to impact over 100 malignant and auto-immune diseases. Orca has assembled a team of world-leading experts and technologists to execute this vision.

Kentik

Venture Round in 2020
Kentik Technologies, Inc. is a network intelligence platform that delivers cloud-based real-time visibility and analytics solutions for network and security operators. Founded in 2014 and headquartered in San Francisco, California, the company offers Kentik Detect, a big data-based software-as-a-service that transforms network data into actionable intelligence. This platform enables clients to conduct ad-hoc analytics for improved operations, capacity optimization, anomaly resolution, and DDoS detection, thereby enhancing application and service protection. Kentik also provides My Kentik, a self-service network analytics tool, and an AIOps platform aimed at streamlining network operations. Additionally, the company serves various industries, including financial services, media and entertainment, cloud infrastructure, and telecommunications, offering tailored solutions for visibility, performance, detection, planning, and integration. Kentik was previously known as CloudHelix, Inc. before rebranding in September 2014.

Carbon Health

Series B in 2020
Carbon Health is a tech-enabled healthcare company founded in 2015 and headquartered in San Francisco, California. It provides a mobile application that facilitates primary care services, allowing users to manage their treatment plans, prescriptions, and lab reports in one place. The company offers omnichannel care through various access points, including clinics, pop-up sites, video consultations, and its application, ensuring convenient and accessible healthcare for patients. Additionally, Carbon Health developed a coronavirus assessment tool and has established COVID-19 testing sites in California, further enhancing its commitment to delivering comprehensive healthcare services.

Pivot Bio

Series C in 2020
Pivot Bio is a biotechnology company founded in 2010 and based in Emeryville, California, that focuses on enhancing crop nutrition through the use of engineered microbes. The company leverages its deep understanding of the plant microbiome, employing engineering principles and data science to map microbial dynamics and develop beneficial traits. Pivot Bio's proprietary ON Technology utilizes naturally occurring microbes to provide crops with essential nutrients, particularly nitrogen, which is crucial for growth. This innovative approach aims to replace synthetic nitrogen fertilizers, thereby reducing the environmental impact associated with conventional farming practices. By enhancing crops' ability to capture and metabolize atmospheric nitrogen, Pivot Bio seeks to lower farming costs, improve crop yields, and contribute to a sustainable agricultural future that benefits both the planet and food supply.

Unlearn

Series A in 2020
Unlearn is a San Francisco-based company founded in 2017 that specializes in using artificial intelligence to enhance clinical research. It develops innovative software tools aimed at improving clinical trial design, including the creation of Digital Twins to generate Intelligent Control Arms. By utilizing historical datasets and disease-specific machine-learning models, Unlearn produces virtual placebo patients derived from actual patient baseline data, which helps to increase trial power, accelerate timelines, and provide patient-level insights. This approach reduces or eliminates the need for concurrent control arms in clinical studies, streamlining the research process. Unlearn has garnered significant attention, securing $20 million in funding and collaborating with leading pharmaceutical companies. Its work has been recognized in prestigious publications, including a peer-reviewed article in Nature, and it has been acknowledged as a key player in digital health innovation. The company continues to engage with regulators and industry leaders to drive advancements in clinical research through the application of AI technologies.

Culture Biosciences

Series A in 2020
Culture Biosciences, founded in 2016 and headquartered in San Francisco, California, specializes in developing automated bioreactors and tools for fermentation. The company provides a digital bio-manufacturing platform that allows biotech companies to optimize their manufacturing processes, enabling them to bring products to market more efficiently. By utilizing robotic sample handling and cloud-based data monitoring and analysis, Culture Biosciences helps scientists run, monitor, and analyze bioreactors more quickly than traditional methods. This innovative approach supports the biotechnology sector in enhancing productivity and streamlining workflows.

MycoWorks

Series A in 2020
MycoWorks LLC specializes in the research, design, and manufacturing of sustainable leather alternatives derived from natural mycelium. Established in 2013 and based in San Francisco, the company produces a proprietary material called Reishi, which is water-resistant and customizable in texture and features. Reishi is designed to mimic the performance and feel of traditional leather while being animal-free and environmentally friendly. MycoWorks employs a unique platform known as Fine Mycelium to create this innovative biomaterial, which boasts qualities such as strength, durability, and biodegradability. The company aims to provide natural alternatives to conventional materials like plastic foams, textiles, and leather, catering to industries such as aerospace, automotive, apparel, and architectural interiors. Through its carbon-negative production process, MycoWorks offers a rapidly grown solution that aligns with sustainable design principles.

MycoWorks

Series A in 2020
MycoWorks LLC specializes in the research, design, and manufacturing of sustainable leather alternatives derived from natural mycelium. Established in 2013 and based in San Francisco, the company produces a proprietary material called Reishi, which is water-resistant and customizable in texture and features. Reishi is designed to mimic the performance and feel of traditional leather while being animal-free and environmentally friendly. MycoWorks employs a unique platform known as Fine Mycelium to create this innovative biomaterial, which boasts qualities such as strength, durability, and biodegradability. The company aims to provide natural alternatives to conventional materials like plastic foams, textiles, and leather, catering to industries such as aerospace, automotive, apparel, and architectural interiors. Through its carbon-negative production process, MycoWorks offers a rapidly grown solution that aligns with sustainable design principles.

Empirico

Series A in 2020
Empirico is a company focused on developing an insights platform that leverages biological insights derived from human genetics to create new medicines. Its platform utilizes biological datasets and programmable biology to facilitate target discovery and development. This enables scientists to systematically generate, examine, and prioritize high-confidence therapeutic hypotheses, ultimately advancing the field of drug development through innovative approaches grounded in human genetic research.

Novome Biotechnologies

Series A in 2020
Novome Biotechnologies, Inc. is a biotechnology company based in South San Francisco, California, that specializes in engineering bacteria from the human gut to address chronic diseases. Founded in 2015, the company has developed a platform for the controlled colonization of the gut with genetically engineered bacteria, known as Genetically Engineered Microbial Medicines (GEMMs). This innovative approach allows for sustained therapeutic interventions through the precise delivery of microbial activities. Novome's lead preclinical program targets hyperoxaluria by creating a therapeutic strain of bacteria aimed at degrading oxalate to help prevent kidney stone formation. The company is also expanding its synthetic biology platform to explore additional therapeutic applications.

Novome Biotechnologies

Series A in 2020
Novome Biotechnologies, Inc. is a biotechnology company based in South San Francisco, California, that specializes in engineering bacteria from the human gut to address chronic diseases. Founded in 2015, the company has developed a platform for the controlled colonization of the gut with genetically engineered bacteria, known as Genetically Engineered Microbial Medicines (GEMMs). This innovative approach allows for sustained therapeutic interventions through the precise delivery of microbial activities. Novome's lead preclinical program targets hyperoxaluria by creating a therapeutic strain of bacteria aimed at degrading oxalate to help prevent kidney stone formation. The company is also expanding its synthetic biology platform to explore additional therapeutic applications.

Pyka

Seed Round in 2019
Pyka, Inc. specializes in the development of autonomous electric aircraft, primarily aimed at the agricultural sector. Founded in 2016 and headquartered in Oakland, California, the company creates aircraft designed for the application and spraying of chemicals on agricultural lands. These planes are equipped with advanced technology, including autonomous flight controllers, onboard sensors, and systems for obstacle detection and path planning. This enables them to navigate various terrains and perform hyper-short takeoffs and landings from nearly any location. Pyka's aircraft are notable for being the first certified electric autonomous airplanes to operate commercially, providing an innovative and efficient alternative to traditional ground transit in agriculture.

Pyka

Seed Round in 2019
Pyka, Inc. specializes in the development of autonomous electric aircraft, primarily aimed at the agricultural sector. Founded in 2016 and headquartered in Oakland, California, the company creates aircraft designed for the application and spraying of chemicals on agricultural lands. These planes are equipped with advanced technology, including autonomous flight controllers, onboard sensors, and systems for obstacle detection and path planning. This enables them to navigate various terrains and perform hyper-short takeoffs and landings from nearly any location. Pyka's aircraft are notable for being the first certified electric autonomous airplanes to operate commercially, providing an innovative and efficient alternative to traditional ground transit in agriculture.

Empirico

Series A in 2019
Empirico is a company focused on developing an insights platform that leverages biological insights derived from human genetics to create new medicines. Its platform utilizes biological datasets and programmable biology to facilitate target discovery and development. This enables scientists to systematically generate, examine, and prioritize high-confidence therapeutic hypotheses, ultimately advancing the field of drug development through innovative approaches grounded in human genetic research.

Capella Space

Series B in 2019
Capella Space is a San Francisco-based company specializing in commercial radar satellite technology. It operates a constellation of small satellites that utilize synthetic aperture radar to capture high-resolution images of the Earth's surface, achieving clarity even in challenging conditions such as clouds, smoke, and darkness. The imagery provided is sub-meter in resolution and serves various industries, including defense, disaster response, agriculture, and infrastructure monitoring. By offering timely and flexible access to critical geospatial information, Capella Space enhances decision-making related to commerce, conservation, and public safety. Founded in 2014, the company aims to make Earth observation an integral tool for understanding and addressing the dynamic changes occurring globally.

X-37

Series A in 2019
X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, established in 2018. The company specializes in developing treatments for cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, X-37 aims to discover novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach enables the healthcare sector to expedite the discovery and development of new medicines, ultimately benefiting patients in need of effective therapies.

X-37

Series A in 2019
X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, established in 2018. The company specializes in developing treatments for cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, X-37 aims to discover novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach enables the healthcare sector to expedite the discovery and development of new medicines, ultimately benefiting patients in need of effective therapies.

Verdant Robotics

Seed Round in 2019
Verdant Robotics, Inc. specializes in the development of artificial intelligence-based robotic solutions aimed at enhancing agricultural practices. Founded in 2018 and headquartered in Hayward, California, the company offers technology that digitally maps farms over time and space, allowing for the automatic tracking and treatment of individual plants. By utilizing robotics, computer vision, and machine learning, Verdant Robotics aims to improve grower profits through precise and efficient agricultural methods. In addition to its technological offerings, the company provides autonomous farming services to support modern agricultural needs.

Plexium

Series A in 2019
Plexium, Inc. is a biotechnology company based in San Diego, California, established in 2017. The company specializes in drug development, focusing on the identification of small molecules that modulate E3 ligases for therapeutic applications in cancer and neurodegenerative diseases. Plexium employs a DNA-encoded library platform to conduct high-throughput screening, utilizing cell-based assays to discover molecular glues that can alter E3 ligase substrate recognition, thereby inducing, inhibiting, or modulating protein degradation. This innovative approach allows Plexium to selectively target various cancers, including small cell lung and breast tumors, while also exploring mechanisms to enhance immune responses through E3 ligase modulation.

Smartex

Seed Round in 2019
Smartex focuses on addressing significant challenges in the textile industry by leveraging advanced AI technology, specifically machine learning and computer vision. The company has developed a hardware-enabled software solution that detects textile defects and irregularities in real time. By implementing this innovative system, Smartex can halt production when defects are identified, thereby minimizing defective output and reducing textile waste. This proactive approach not only enhances production efficiency but also contributes to sustainability by lowering carbon dioxide emissions, energy consumption, and water usage. Moreover, Smartex provides factories with a user interface to monitor production statistics, further improving operational insights and decision-making capabilities.

Embark Trucks

Series C in 2019
Embark Trucks Inc. develops self-driving truck technology and highway autopilot system for commercial trucking. It designs artificial intelligence software that helps on long haul stretches in the trucking industry. Embark Trucks Inc. was formerly known as Varden Labs Inc. The company was founded in 2015 and is based in San Francisco, California.

PerimeterX

Series C in 2019
PerimeterX, Inc. is a cybersecurity firm that specializes in detecting and preventing automated attacks on web infrastructure. Founded in 2014 and headquartered in San Mateo, California, with additional offices in London, Miami, and Tel Aviv, the company offers a range of security solutions designed to protect organizations from malicious web behavior. Its flagship product, PerimeterX Bot Defender, utilizes behavioral analytics to identify and mitigate various types of bot attacks, including account abuse, web scraping, and marketing fraud. The company also provides specialized solutions for mobile applications and application programming interfaces (APIs), ensuring comprehensive protection across different platforms. Serving industries such as e-commerce, travel, hospitality, and enterprise software, PerimeterX is recognized for its advanced threat protection technology that effectively distinguishes between legitimate users and automated threats.

Tala

Series D in 2019
Tala is a mobile technology and data science company focused on providing financial services in emerging markets. Founded in 2011 and headquartered in Santa Monica, with additional offices in Nairobi, Manila, Dar Es Salaam, Mexico City, Mumbai, and Bangalore, Tala has helped over 2 million users access personal loans through its smartphone app. The platform utilizes data to create instant credit scores for individuals lacking formal credit or banking history, enabling them to receive personalized loans and build digital credit profiles. The app streamlines the entire lending process, allowing users to apply for loans, receive funds, and track their status seamlessly. Tala aims to empower clients by offering accessible financial services that facilitate borrowing, saving, and overall financial growth.

Earth AI

Seed Round in 2019
Earth AI Pty Ltd. is an innovative mineral exploration company based in Parramatta, Australia, founded in 2016. The company specializes in developing artificial intelligence-based software that identifies potential areas of mineralization in remote locations lacking pre-existing geological data. By using AI mineral targeting technology, Earth AI provides geologists with location suggestions for mineral exposure and automatically generates detailed geological maps from satellite, geophysical, and geochemical datasets. This approach allows Earth AI to discover new metal deposits valued between $10 million and $100 million significantly faster and at a lower cost than traditional methods. The company's field-proven system is reported to be 50 times more successful in identifying mineralized prospects and achieves five times cheaper field operations through hardware automation and streamlined processes. Earth AI focuses on various metals, including copper, lead, zinc, nickel, cobalt, vanadium, and rare earth elements, effectively enhancing the chances of successful mineral discovery while minimizing operational risks and expenses.

Lucira Health

Series B in 2019
Lucira Health develops a new class of professional and home-health solutions to help illuminate and elucidate health status to expedite decision-making and treatment. The company's at-home test kit is well suited for home use and the molecular nucleic acid amplification technology is adaptable to COVID-19 detection. Lucira Health produces inexpensive, disposable health diagnostic hardware that transforms any smartphone into a portable, real-time health-monitoring device for rapid, accessible, multiplexed analysis of bodily fluids anywhere in the world. It enables consumers to take the first step in their healthcare management through at-home diagnosis and a companion mobile app to provide follow up treatment. Lucira Health was founded in 2013 and is headquartered in Emeryville, California, United States.

Strateos

Venture Round in 2019
Strateos operates a robotic cloud laboratory that automates chemistry, biology, and tissue analysis to enhance drug discovery processes. By integrating advanced robotics, control systems, and sophisticated imaging and analytics software, Strateos allows pharmaceutical companies to discover new drug candidates more efficiently. The company emerged from a merger between Transcriptic, known for its pioneering robotic cloud laboratory platform, and 3Scan, which specialized in using automation and machine learning to analyze tissue samples. This combination enables Strateos to provide a comprehensive suite of technologies designed to streamline the drug discovery and early development phases. By transforming life science methodologies into data-driven processes, Strateos aims to create a more efficient and cost-effective approach to scientific research, positioning itself as a valuable partner to biotechnology firms seeking to innovate in the field.

Frontier Medicines

Series A in 2019
Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company specializes in discovering and developing medicines that target cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational techniques and machine learning to identify new binding pockets on proteins, thereby facilitating the discovery and development of small-molecule drugs. By enhancing the drug development process, Frontier Medicines aims to deliver breakthrough therapies that can significantly change the treatment landscape for debilitating diseases.

Frontier Medicines

Series A in 2019
Frontier Medicines Corporation is a pre-clinical stage biopharmaceutical company based in South San Francisco, California, founded in 2018. The company specializes in discovering and developing medicines that target cancer-causing proteins through its innovative chemoproteomics platform. This platform utilizes advanced computational techniques and machine learning to identify new binding pockets on proteins, thereby facilitating the discovery and development of small-molecule drugs. By enhancing the drug development process, Frontier Medicines aims to deliver breakthrough therapies that can significantly change the treatment landscape for debilitating diseases.

Mythic

Series B in 2019
Mythic Inc. is a technology company that specializes in designing and developing silicon chips and artificial intelligence (AI) processing units. Founded in 2012 and headquartered in Redwood City, California, with an office in Austin, Texas, Mythic focuses on creating analog matrix processors that enable AI capabilities across a range of devices, from fitness bands and hearing aids to self-driving cars and robotic drones. The company’s flagship products include the M1076 Analog Matrix Processor and various PCIe and M.2 cards. Mythic's technology integrates hybrid digital and analog computations within flash arrays, providing desktop-grade compute power in a compact form factor while maintaining performance, energy efficiency, and accuracy. The company has assembled a diverse team of experts in neural networks, software design, and processor architecture to advance AI deployment in real-world environments.

SentinelOne

Series D in 2019
SentinelOne is a cloud-based cybersecurity company founded in 2013, headquartered in Mountain View, California. It specializes in autonomous endpoint protection, offering its Singularity platform, which provides comprehensive detection and response capabilities against various security threats. The platform integrates behavioral-based detection, advanced mitigation, and forensic tools to address attacks that employ evasion techniques, ensuring real-time threat prevention. Recognized as a leader in the field, SentinelOne has received accolades for its innovative approach, including being named a Visionary in Gartner's Endpoint Protection Magic Quadrant and featuring on the Forbes AI 50 list for its effective use of artificial intelligence. The company has also achieved independent certifications validating its solutions as true antivirus replacements across multiple operating systems. SentinelOne's founding team comprises experts from top cybersecurity firms, reflecting its strong foundation in the industry.

Carbon Health

Series B in 2019
Carbon Health is a tech-enabled healthcare company founded in 2015 and headquartered in San Francisco, California. It provides a mobile application that facilitates primary care services, allowing users to manage their treatment plans, prescriptions, and lab reports in one place. The company offers omnichannel care through various access points, including clinics, pop-up sites, video consultations, and its application, ensuring convenient and accessible healthcare for patients. Additionally, Carbon Health developed a coronavirus assessment tool and has established COVID-19 testing sites in California, further enhancing its commitment to delivering comprehensive healthcare services.

Plexium

Series A in 2019
Plexium, Inc. is a biotechnology company based in San Diego, California, established in 2017. The company specializes in drug development, focusing on the identification of small molecules that modulate E3 ligases for therapeutic applications in cancer and neurodegenerative diseases. Plexium employs a DNA-encoded library platform to conduct high-throughput screening, utilizing cell-based assays to discover molecular glues that can alter E3 ligase substrate recognition, thereby inducing, inhibiting, or modulating protein degradation. This innovative approach allows Plexium to selectively target various cancers, including small cell lung and breast tumors, while also exploring mechanisms to enhance immune responses through E3 ligase modulation.

Jupiter Intelligence

Series B in 2019
Jupiter Intelligence, Inc. specializes in developing tools and platforms that provide comprehensive weather and climate data, trend visualizations, forecasts, and risk assessments. The company offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate multiple prediction models based on data from millions of ground-based and satellite sensors. Additionally, Jupiter provides FloodScore and HeatScore services, which help users prepare for flooding and mitigate temperature-related impacts from climate change, respectively. These services focus on climate risk assessment and management in urban regions such as New York City, South Florida, and the Atlantic Coast, with plans for global expansion. Jupiter's models are informed by the latest scientific research from the global Earth and Ocean Systems community. Founded in 2017 and based in San Mateo, California, Jupiter Intelligence was previously known as Jupiter Technology Systems, Inc. before rebranding in December 2017.

Unlearn

Seed Round in 2019
Unlearn is a San Francisco-based company founded in 2017 that specializes in using artificial intelligence to enhance clinical research. It develops innovative software tools aimed at improving clinical trial design, including the creation of Digital Twins to generate Intelligent Control Arms. By utilizing historical datasets and disease-specific machine-learning models, Unlearn produces virtual placebo patients derived from actual patient baseline data, which helps to increase trial power, accelerate timelines, and provide patient-level insights. This approach reduces or eliminates the need for concurrent control arms in clinical studies, streamlining the research process. Unlearn has garnered significant attention, securing $20 million in funding and collaborating with leading pharmaceutical companies. Its work has been recognized in prestigious publications, including a peer-reviewed article in Nature, and it has been acknowledged as a key player in digital health innovation. The company continues to engage with regulators and industry leaders to drive advancements in clinical research through the application of AI technologies.

PerimeterX

Series C in 2019
PerimeterX, Inc. is a cybersecurity firm that specializes in detecting and preventing automated attacks on web infrastructure. Founded in 2014 and headquartered in San Mateo, California, with additional offices in London, Miami, and Tel Aviv, the company offers a range of security solutions designed to protect organizations from malicious web behavior. Its flagship product, PerimeterX Bot Defender, utilizes behavioral analytics to identify and mitigate various types of bot attacks, including account abuse, web scraping, and marketing fraud. The company also provides specialized solutions for mobile applications and application programming interfaces (APIs), ensuring comprehensive protection across different platforms. Serving industries such as e-commerce, travel, hospitality, and enterprise software, PerimeterX is recognized for its advanced threat protection technology that effectively distinguishes between legitimate users and automated threats.

Alation

Series C in 2019
Alation, Inc. is a company that specializes in data intelligence solutions, providing an AI-driven platform designed for data search and discovery, governance, stewardship, and analytics. Founded in 2012 and headquartered in Redwood City, California, Alation aims to enhance the way organizations find, understand, and trust their data. Its innovative platform integrates machine learning with human collaboration to facilitate confident data-driven decisions. Alation's offerings include a data catalog that supports metadata management and self-service analytics, enabling users to understand data origins, usage, and governance. The company serves a diverse range of clients, including notable organizations such as the City of San Diego, eBay, Munich Re, and Pfizer, and is backed by several venture capital firms.

Zymergen

Series C in 2018
Zymergen, Inc. is a biotechnology company that focuses on researching, developing, and manufacturing microbes for various industries, including agriculture, chemicals, materials, pharmaceuticals, electronics, and personal care. The company integrates automation, machine learning, and genomics to enhance its platform, which aids in optimizing microbial strains and improving the efficiency of production processes. By leveraging big data and artificial intelligence, Zymergen collaborates with clients to engineer novel molecules from microbes, thereby advancing product development. Founded in 2013 and headquartered in Emeryville, California, Zymergen also has offices in Boise, Idaho; Medford, Massachusetts; Seattle, Washington; and Tokyo, Japan, enabling it to serve a global clientele effectively.

Genedit

Seed Round in 2018
GenEdit Inc. is a biotechnology company based in Berkeley, California, established in 2016. It specializes in developing innovative genome editing technologies, particularly using the CRISPR/Cas9 system for therapeutic gene editing. The company focuses on addressing the challenges associated with the delivery of gene therapies through its proprietary non-viral nanoparticle-based delivery platform. This platform enables more efficient and accurate delivery of CRISPR components, enhancing the potential for curative treatments for genetic diseases. By systematically screening a library of nanoparticles, GenEdit aims to improve the safety and effectiveness of gene editing, making it a promising solution for a wide range of therapeutic applications.

Genedit

Seed Round in 2018
GenEdit Inc. is a biotechnology company based in Berkeley, California, established in 2016. It specializes in developing innovative genome editing technologies, particularly using the CRISPR/Cas9 system for therapeutic gene editing. The company focuses on addressing the challenges associated with the delivery of gene therapies through its proprietary non-viral nanoparticle-based delivery platform. This platform enables more efficient and accurate delivery of CRISPR components, enhancing the potential for curative treatments for genetic diseases. By systematically screening a library of nanoparticles, GenEdit aims to improve the safety and effectiveness of gene editing, making it a promising solution for a wide range of therapeutic applications.

X-37

Seed Round in 2018
X-37, LLC is a pharmaceutical discovery and development company based in South San Francisco, California, established in 2018. The company specializes in developing treatments for cancer, autoimmune diseases, and coagulation disorders. Utilizing advanced artificial intelligence technology from Atomwise, X-37 aims to discover novel drug candidates by screening extensive libraries of chemical compounds against significant pharmaceutical targets. This innovative approach enables the healthcare sector to expedite the discovery and development of new medicines, ultimately benefiting patients in need of effective therapies.

Pachyderm

Series A in 2018
Pachyderm, Inc. is a software company that specializes in developing a data engineering platform for managing complex, multi-stage data pipelines. Founded in 2014 and based in San Francisco, California, Pachyderm's platform facilitates the automation of data processes while ensuring reproducibility and data lineage throughout the machine learning development lifecycle. It offers a unique architecture that supports version control for data, allowing users to build scalable and language-agnostic machine learning and ETL workflows. The company's solutions include a free open-source version, an enterprise version, and a hub version, providing flexibility for users to choose the best fit for their needs. By enabling automatic scaling and parallel processing, Pachyderm empowers data science teams to work with any language, framework, or tool, making it an effective choice for sophisticated data transformations.

Empirico

Series A in 2018
Empirico is a company focused on developing an insights platform that leverages biological insights derived from human genetics to create new medicines. Its platform utilizes biological datasets and programmable biology to facilitate target discovery and development. This enables scientists to systematically generate, examine, and prioritize high-confidence therapeutic hypotheses, ultimately advancing the field of drug development through innovative approaches grounded in human genetic research.

Reach

Series A in 2018
Founded out of MIT, Reach Labs is deeply rooted in technology and design. Their mission is to empower the world with seamless connectivity.

Empirico

Series A in 2018
Empirico is a company focused on developing an insights platform that leverages biological insights derived from human genetics to create new medicines. Its platform utilizes biological datasets and programmable biology to facilitate target discovery and development. This enables scientists to systematically generate, examine, and prioritize high-confidence therapeutic hypotheses, ultimately advancing the field of drug development through innovative approaches grounded in human genetic research.

Area 1 Security

Series C in 2018
Area 1 Security, Inc. is a cybersecurity firm based in Redwood City, California, that specializes in eliminating targeted cyber-attacks. Founded in 2013 by experts from the NSA and MIT, the company has developed Area 1 Horizon, a cloud-based solution designed to identify and mitigate phishing attacks early in their lifecycle. This solution provides advanced warning by analyzing threat campaigns, attacker infrastructure, and delivery mechanisms. Area 1 Security's technology addresses various attack vectors, including email, web, and network threats, enabling organizations to visualize, contextualize, and preempt cyber threats effectively. The company has raised significant funding from notable investors, underscoring its commitment to combating socially engineered cyber threats.

Gradle Inc.

Series B in 2018
Gradle, Inc. is a developer of open-source build automation software that aims to transform the software development process. The Gradle Build Tool is widely recognized as the most popular build tool for open-source JVM projects, averaging over 19 million downloads monthly and being utilized by notable projects such as Spring Boot and JUnit. Gradle Enterprise complements this by providing a software build performance acceleration and analytics platform, designed to enhance productivity for software development teams. This self-hosted solution utilizes advanced acceleration technologies to reduce build times significantly and employs data analytics for efficient troubleshooting. Gradle Enterprise supports the discipline of Developer Productivity Engineering, enhancing the build and test processes within both Gradle and Maven environments. By unifying and automating build processes, Gradle, Inc. enables enterprises to improve their software delivery capabilities effectively.

Plexium

Seed Round in 2018
Plexium, Inc. is a biotechnology company based in San Diego, California, established in 2017. The company specializes in drug development, focusing on the identification of small molecules that modulate E3 ligases for therapeutic applications in cancer and neurodegenerative diseases. Plexium employs a DNA-encoded library platform to conduct high-throughput screening, utilizing cell-based assays to discover molecular glues that can alter E3 ligase substrate recognition, thereby inducing, inhibiting, or modulating protein degradation. This innovative approach allows Plexium to selectively target various cancers, including small cell lung and breast tumors, while also exploring mechanisms to enhance immune responses through E3 ligase modulation.

Capella Space

Series B in 2018
Capella Space is a San Francisco-based company specializing in commercial radar satellite technology. It operates a constellation of small satellites that utilize synthetic aperture radar to capture high-resolution images of the Earth's surface, achieving clarity even in challenging conditions such as clouds, smoke, and darkness. The imagery provided is sub-meter in resolution and serves various industries, including defense, disaster response, agriculture, and infrastructure monitoring. By offering timely and flexible access to critical geospatial information, Capella Space enhances decision-making related to commerce, conservation, and public safety. Founded in 2014, the company aims to make Earth observation an integral tool for understanding and addressing the dynamic changes occurring globally.

Scuba

Venture Round in 2018
Interana Inc. is a company that specializes in developing a behavioral discovery and analysis platform. This platform allows users to investigate digital behavior, enabling data analysts and product managers to enhance onboarding experiences and feature utilization. Founded in 2013 and headquartered in Redwood City, California, Interana also has locations in Dallas, Texas, and Bellevue, Washington. The company's technology is designed to analyze vast amounts of data quickly, helping organizations understand customer behavior and product usage effectively.

Embark Trucks

Series B in 2018
Embark Trucks Inc. develops self-driving truck technology and highway autopilot system for commercial trucking. It designs artificial intelligence software that helps on long haul stretches in the trucking industry. Embark Trucks Inc. was formerly known as Varden Labs Inc. The company was founded in 2015 and is based in San Francisco, California.

Vium

Series B in 2018
Vium, Inc. is a biotechnology company focused on transforming preclinical research and enhancing animal welfare through the development of digital biomarkers. Founded in 2013 and headquartered in San Mateo, California, Vium employs advanced technologies such as artificial intelligence, machine learning, and sensor technology to create its Digital Vivarium and Vium Cloud platforms. These platforms enable non-invasive collection of physiological metrics and behaviors, yielding more sensitive and accurate data for researchers. Vium's offerings cater to a diverse clientele, including biotechnology, pharmaceutical, and computational drug discovery firms, as well as academic institutions and therapeutic labs. The company is fully accredited by AAALAC International and has received commendations for its commitment to humane animal research, adhering to the principles of the 3 Rs—Replacement, Reduction, and Refinement. By providing critical insights into disease progression, Vium assists researchers in making informed decisions about which compounds should advance to clinical trials, thereby accelerating the drug discovery and development pipeline.

Subtle Medical

Seed Round in 2018
Subtle Medical, Inc., a healthcare technology company, develops medical imaging software for clinical imaging centers and hospitals. Its product includes SubtleMR, an artificial intelligence-based image processing software that reduces image noise and increases image sharpness for non-contrast enhanced magnetic resonance imaging (MRI). It enables to reduce cost, imaging time, and radiation/contrast dose. The company was founded in 2017 and is based in Menlo Park, California.

Orca Bio

Series C in 2018
Orca Bio is a clinical-stage cell therapy company dedicated to delivering curative medicine to these patients. Orca Bio has developed a pipeline of proprietary technologies that have the potential to impact over 100 malignant and auto-immune diseases. Orca has assembled a team of world-leading experts and technologists to execute this vision.

MemSQL

Series D in 2018
SingleStore, Inc. is a provider of relational databases designed for both cloud and on-premises transactions and analytics. The company offers the SingleStore Managed Service, a cloud database-as-a-service that facilitates analytics on various cloud platforms, as well as SingleStore DB, a distributed SQL database suitable for operational analytics on bare metal and hybrid cloud environments. SingleStore's solutions include modernizing data platforms, securing government workloads, IoT analytics, and customer interaction management, serving diverse sectors such as financial services, media, energy, government, and retail. Founded in 2011 and headquartered in San Francisco, California, SingleStore also has offices in Seattle, Boston, Portland, Lisbon, and London. Previously known as MemSQL Inc., the company rebranded to SingleStore, Inc. in October 2020.

Tala

Series C in 2018
Tala is a mobile technology and data science company focused on providing financial services in emerging markets. Founded in 2011 and headquartered in Santa Monica, with additional offices in Nairobi, Manila, Dar Es Salaam, Mexico City, Mumbai, and Bangalore, Tala has helped over 2 million users access personal loans through its smartphone app. The platform utilizes data to create instant credit scores for individuals lacking formal credit or banking history, enabling them to receive personalized loans and build digital credit profiles. The app streamlines the entire lending process, allowing users to apply for loans, receive funds, and track their status seamlessly. Tala aims to empower clients by offering accessible financial services that facilitate borrowing, saving, and overall financial growth.

Mythic

Series B in 2018
Mythic Inc. is a technology company that specializes in designing and developing silicon chips and artificial intelligence (AI) processing units. Founded in 2012 and headquartered in Redwood City, California, with an office in Austin, Texas, Mythic focuses on creating analog matrix processors that enable AI capabilities across a range of devices, from fitness bands and hearing aids to self-driving cars and robotic drones. The company’s flagship products include the M1076 Analog Matrix Processor and various PCIe and M.2 cards. Mythic's technology integrates hybrid digital and analog computations within flash arrays, providing desktop-grade compute power in a compact form factor while maintaining performance, energy efficiency, and accuracy. The company has assembled a diverse team of experts in neural networks, software design, and processor architecture to advance AI deployment in real-world environments.

Atomwise

Series A in 2018
Atomwise, Inc. specializes in deep learning artificial intelligence technology aimed at small molecule drug discovery. The company leverages its proprietary AI platform, AtomNet, which contains over 16 billion molecules for virtual screening, to enhance the speed and accuracy of drug discovery processes. This technology employs a statistical approach to predict the binding of small molecules to proteins, aiding in drug hit discovery, binding affinity prediction, and toxicity detection. Atomwise collaborates on numerous projects each year with major pharmaceutical and agrochemical companies, as well as over 200 universities and hospitals across 40 countries. Founded in 2012 and based in San Francisco, Atomwise was previously known as Chematria, Inc. before rebranding in 2015.

Jupiter Intelligence

Seed Round in 2018
Jupiter Intelligence, Inc. specializes in developing tools and platforms that provide comprehensive weather and climate data, trend visualizations, forecasts, and risk assessments. The company offers the ClimateScore Intelligence Platform, which utilizes cloud computing to integrate multiple prediction models based on data from millions of ground-based and satellite sensors. Additionally, Jupiter provides FloodScore and HeatScore services, which help users prepare for flooding and mitigate temperature-related impacts from climate change, respectively. These services focus on climate risk assessment and management in urban regions such as New York City, South Florida, and the Atlantic Coast, with plans for global expansion. Jupiter's models are informed by the latest scientific research from the global Earth and Ocean Systems community. Founded in 2017 and based in San Mateo, California, Jupiter Intelligence was previously known as Jupiter Technology Systems, Inc. before rebranding in December 2017.

Nyriad

Series A in 2018
Nyriad Limited is a technology company that specializes in advanced storage solutions tailored for big data and high-performance computing. Established in 2015 and based in Cambridge, New Zealand, Nyriad develops innovative products such as NSULATE, an ultra-fast erasure coding solution; NPAC, which offers parallel accelerated compression for real-time storage and network traffic; and NAPPA, a framework that integrates various compression and encoding codecs into server and client applications. The company’s compression technology platform leverages graphics processing units (GPUs) to deliver resilient data storage, addressing the scale, security, efficiency, and performance requirements of demanding IT projects. Nyriad's offerings support both storage and computing performance, catering to the needs of systems integrators and organizations engaged in high-performance data-driven initiatives.

Akash Systems

Seed Round in 2018
Akash Systems is focused on developing and supplying the next generation of small satellites (CubeSats), satellite transmitters, and the RF Power Amplifiers. The company uses new composite material, gallium nitride (GaN)-on-Diamond, invented by Akash cofounder Ejeckam, for their products. GaN-on-Diamond provides a cooler state of operation which improves energy efficiency and reduces a system's size, weight, and operating costs. Akash Systems was founded in 2016 by Felix Ejeckam and Ty Mitchell and is headquartered in San Francisco, CA.

Anjuna

Seed Round in 2018
Anjuna Security Inc. is a cybersecurity company based in Palo Alto, California, that specializes in a data-in-use platform designed to protect sensitive data during processing, transit, and at rest. Founded in 2017, Anjuna's technology enables organizations to secure their applications and key management systems in the cloud without requiring any changes to existing code. The platform creates a software perimeter around applications, delivering hardware-grade security that allows sensitive workloads to operate safely in public cloud environments. This approach eliminates the need for securing or patching the underlying infrastructure, as it protects applications even against threats from users with root or physical access. By seamlessly encrypting data end-to-end with secure enclaves, Anjuna empowers enterprises to run their most critical operations while maintaining robust security against insider threats.
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