National Science Foundation

The National Science Foundation (NSF), established in 1950 and located in Alexandria, Virginia, is an independent federal agency dedicated to advancing fundamental research and education across all scientific and engineering disciplines. With an annual budget of approximately $7.8 billion, the NSF operates America's Seed Fund, which allocates nearly $200 million each year to support startups and small businesses through the Small Business Innovation Research (SBIR) program. This initiative provides non-dilutive funding of up to $1.5 million to assist in research and development efforts, thereby facilitating the transformation of scientific discoveries into commercially viable products and services. By helping to de-risk technology, the NSF plays a crucial role in fostering innovation and addressing societal challenges through scientific advancements.

James Donlon

Program Director

Sean L. Jones

Assistant Director for Mathematical and Physical Sciences

Sethuraman Panchanathan

Director

Ben Schrag Ph.D

Program Director and Policy Liaison, SBIR / STTR

Past deals in Impact Investing

The Institute for Integrative and Innovative Research (I³R) at the University of Arkansas is a new model of public research and economic development. It works with commercial, philanthropic, non-profit, and governmental organizations to deliver positive societal impact by bringing the discoveries of the future to the world in real-time.

Earthshot Labs

Grant in 2022
Developer of a climate mitigation platform designed for ecological restoration at a planetary scale. The company's platform develops a comprehensive tool for people all around the world to algorithmically determine the specific regenerative strategies for individual land parcels and landscape-level ecosystem regeneration, enabling clients to realize their land's full natural and economic potential.

InvVax

Grant in 2022
InvVax, Inc. develops and commercializes influenza vaccine that prevents pandemics. It focuses on identifying influenza vaccines for HIV, Hepatitis B, and Hepatitis C. The company was founded in 2012 and is based in Los Angeles, California.

Ocean

Grant in 2022
Eco-Shelter is a social enterprise founded in 2017 by Alexa Bednar, based in Seattle, Washington. The company focuses on providing safe and affordable roofing solutions for low-income households in India. It specializes in sustainable building materials, offering an eco-roof panel made from resin-coated bamboo mats. These panels are pressed and sealed to create a strong, lightweight, water-resistant, and flame-resistant roofing option. Through its innovative products, Eco-Shelter aims to improve living conditions for underprivileged communities by delivering accessible and environmentally friendly building solutions.

Biko Biolabs

Grant in 2021
Biko Biolabs is a research company founded in 2020 and located in Somerville, Massachusetts, that focuses on the intersection of plastic waste and regenerative agriculture. The company aims to address research and development gaps related to sustainability and self-sufficiency in traditionally marginalized communities. By providing resources to innovators, Biko Biolabs fosters the creation of new economic opportunities and trains emerging local scientists and engineers. The company emphasizes impactful research that is closely aligned with the specific needs of the communities involved, enabling tailored scientific practices and technologies that directly address fundamental community challenges.

Earthshot Labs

Grant in 2021
Developer of a climate mitigation platform designed for ecological restoration at a planetary scale. The company's platform develops a comprehensive tool for people all around the world to algorithmically determine the specific regenerative strategies for individual land parcels and landscape-level ecosystem regeneration, enabling clients to realize their land's full natural and economic potential.

Jet-Set Offset

Grant in 2021
Jet-Set Offset is a donation-based carbon-offsetting tool for air travel, and a consumer-friendly alternative to the traditional carbon marketplace. Our site operates as a fundraising tool for environmental nonprofit organizations and facilitates automatic, mileage-based donations from travelers' flights. We've developed this approach to raise awareness of the environmental impact of air travel and inspire eco-conscious travelers and businesses to take action. Travelers and companies can subscribe to Jet-Set Offset and choose to support a nonprofit organization automatically with a one cent-per-mile donation every time they, or their employees, fly. Our nonprofit partners are working towards local climate solutions across the country, operating certified carbon offset and credit projects, as well as advocacy, education, renewable energy, reforestation, and/or conservation programs.

Impact Proteomics

Grant in 2021
Impact Proteomics, LLC specializes in protein sample preparation, offering a range of kits and reagents designed to produce contaminant-free samples. Founded in 2017 and based in Pittsburgh, Pennsylvania, the company provides various products, including Universal Protein Extraction and Clean Kits for peptides, whole proteins, and immunoprecipitation, as well as Promtag Reversible Protein Tagging Agents and related accessories. By supplying tools for efficient protein handling, Impact Proteomics aims to enhance drug and biomarker discovery processes, allowing researchers to accelerate the development of therapeutics and diagnostics. The company's offerings are available for purchase online, reflecting its commitment to supporting the scientific community in advancing medical research.

Instapath

Grant in 2021
Instapath Inc. specializes in designing and developing a microscopy system that enhances the evaluation of cancer biopsies. The company’s technology allows for imaging biopsy samples at subcellular resolution immediately after removal, while also preserving the tissue for future analysis. This innovation aims to address a critical need, as over 7 million Americans undergo biopsy procedures annually, with a significant portion failing to provide accurate diagnoses, leading to costly repeat procedures. By improving rapid on-site evaluation of biopsies, Instapath’s system reduces the necessity for these repeat procedures, thereby increasing operating room efficiency and potentially boosting hospital revenue. Founded in 2017, Instapath is headquartered in New Orleans, Louisiana.

Electra

Grant in 2021
ElectraSteel uses intermittent renewable energy for the electrification and decarbonization of iron and steelmaking. ElectraSteel's investors include leading sustainability-focused global venture capital funds with $300B+ assets under management.

Atlas AI

Grant in 2020
Atlas AI P.B.C is a technology company based in Palo Alto, California, founded in 2018. The company specializes in artificial intelligence-based API software aimed at promoting sustainable development, particularly in emerging markets. Through its web platform, Atlas AI employs machine learning to provide decision-makers with insights that enhance planning, management, and assessment of investments and development programs. The software generates reliable socioeconomic estimates related to agricultural productivity, household asset wealth, and access to essential infrastructure, such as power and transportation. By constructing these measures for Sub-Saharan Africa, Atlas AI enables both private and public organizations to effectively allocate resources and monitor high-stakes initiatives, ultimately advancing economic well-being in the regions they serve.

ClimateAI

Grant in 2020
ClimateAI develops an AI-powered enterprise software platform that enables to predict physical risks of climate change on real assets. It helps investors, insurers, and governments develop climate-resilient strategies. ClimateAI is composed of a team of scientists, engineers, and business leaders from Stanford, Princeton, Harvard, and Berkeley who all believe that climate change is the most important problem of our generation. Thew company was founded in 2017 and is based in San Francisco, California.

Healing Innovations

Grant in 2020
Healing Innovations, Inc. is a medical technology company founded in 2018 and based in Nashville, Tennessee. It specializes in the development and commercialization of advanced rehabilitation equipment aimed at aiding individuals recovering from spinal cord injuries, strokes, traumatic brain injuries, and other neurological conditions such as cerebral palsy, multiple sclerosis, and muscular dystrophy. The company's innovative robotic devices and software enhance the rehabilitation process, enabling clinicians to provide more effective treatment for patients with gait impairments through dynamic weight-bearing activities and locomotor therapy. Healing Innovations collaborates with leading regional innovation organizations to advance its mission of improving patient care and outcomes in various rehabilitation settings.

Infinite Cooling

Grant in 2020
Infinite Cooling Inc. is a company focused on water recovery systems designed for power plants and other industrial facilities. Founded in 2017 and based in Massachusetts, the company employs innovative technology utilizing high-voltage electric fields to capture and recycle water that evaporates from cooling towers. This process significantly reduces water waste and helps mitigate water scarcity. By implementing its systems, Infinite Cooling enables power plants, data centers, and factories to lower their water consumption and treatment costs, promoting sustainability in industrial operations.

Impactivo Consulting

Grant in 2020
Impactivo is a social impact consulting firm that specializes in the field of health and healthcare, childhood and education and philanthropy. They produce solutions that translate research and policy to action and build systemic, operational and strategic funding capacity. Impactivo offers a wide array of services in Strategic Funding, Financial Sustainability, and Program Management to support leaders at the forefront of social innovation in making strategy and organization decisions that lead to exceptional results. They are dedicated to the development of positions that improve the health status, educational attainment, and general wellbeing of the people of people who live in Puerto Rico and abroad.

InnoVein

Grant in 2019
InnoVein, Inc. is a medical device company based in San Carlos, California, focused on developing innovative solutions for vascular health. Founded in 2015, the company specializes in creating an implantable valve designed to regulate blood flow in the veins, particularly for elderly patients suffering from venous insufficiency. Their technology aims to address the challenges associated with this condition, improving the quality of life for affected individuals. As a venture-backed enterprise, InnoVein is committed to advancing cardiac and arterial health through its specialized medical devices.

Lotic Labs

Grant in 2019
Lotic Labs develops innovative software focused on enhancing water markets and advancing environmental finance. By integrating fragmented data sets with advanced environmental science models and financial simulations, Lotic Labs facilitates comprehensive analysis of the interplay between financial, operational, and environmental decisions, particularly within the water utility and heavy industrial sectors. The company’s technology is designed to address environmental financial risks, offering tools for climate risk assessment that help minimize revenue and budget variance for water utilities. Additionally, Lotic Labs provides solutions for environmental modeling and analytics, including contract simulation, impact tracking, and opportunity identification, enabling businesses that rely heavily on natural resources to effectively manage the risks associated with volatile environmental conditions.

Infinite Cooling

Grant in 2019
Infinite Cooling Inc. is a company focused on water recovery systems designed for power plants and other industrial facilities. Founded in 2017 and based in Massachusetts, the company employs innovative technology utilizing high-voltage electric fields to capture and recycle water that evaporates from cooling towers. This process significantly reduces water waste and helps mitigate water scarcity. By implementing its systems, Infinite Cooling enables power plants, data centers, and factories to lower their water consumption and treatment costs, promoting sustainability in industrial operations.

Ocean

Grant in 2019
Eco-Shelter is a social enterprise founded in 2017 by Alexa Bednar, based in Seattle, Washington. The company focuses on providing safe and affordable roofing solutions for low-income households in India. It specializes in sustainable building materials, offering an eco-roof panel made from resin-coated bamboo mats. These panels are pressed and sealed to create a strong, lightweight, water-resistant, and flame-resistant roofing option. Through its innovative products, Eco-Shelter aims to improve living conditions for underprivileged communities by delivering accessible and environmentally friendly building solutions.

Integrative Economics

Grant in 2019
Integrative Economics develops instrument designs for optical insect detection in agricultural settings. The company was founded in 2013 and is headquartered in Portland, Oregon.

Atlas AI

Grant in 2019
Atlas AI P.B.C is a technology company based in Palo Alto, California, founded in 2018. The company specializes in artificial intelligence-based API software aimed at promoting sustainable development, particularly in emerging markets. Through its web platform, Atlas AI employs machine learning to provide decision-makers with insights that enhance planning, management, and assessment of investments and development programs. The software generates reliable socioeconomic estimates related to agricultural productivity, household asset wealth, and access to essential infrastructure, such as power and transportation. By constructing these measures for Sub-Saharan Africa, Atlas AI enables both private and public organizations to effectively allocate resources and monitor high-stakes initiatives, ultimately advancing economic well-being in the regions they serve.

Sironix Renewables

Grant in 2019
Sironix Renewables, Inc. is a Seattle-based company founded in 2016 that specializes in producing environmentally friendly ingredients for cleaning and personal care products derived from plants. The company focuses on the development of oleo-furan surfactant technology, which enables the production of plant-based detergents with fewer harmful chemicals and higher effectiveness. Sironix Renewables aims to create safer consumer products, offering alternatives that are free from harmful additives. Additionally, the company’s innovations have potential applications in various industries, including agricultural pesticides and oil spill remediation, reflecting its commitment to sustainability and safety in industrial consumer products.

Conservation X Labs

Grant in 2019
Conservation X Labs focuses on harnessing technology and entrepreneurship to address the key drivers of human-induced extinction. By utilizing open innovation, the organization runs global innovation competitions that invite diverse participants to propose solutions aimed at conservation challenges. With a blend of in-house expertise and a commitment to scaling early-stage companies, Conservation X Labs aims to create impactful, market-driven solutions that tackle the root causes of extinction rather than merely addressing its symptoms. This approach, termed Conservation 3.0, emphasizes a transformative and interdisciplinary perspective on conservation efforts, positioning the organization at the forefront of environmental innovation.

Impact Proteomics

Grant in 2019
Impact Proteomics, LLC specializes in protein sample preparation, offering a range of kits and reagents designed to produce contaminant-free samples. Founded in 2017 and based in Pittsburgh, Pennsylvania, the company provides various products, including Universal Protein Extraction and Clean Kits for peptides, whole proteins, and immunoprecipitation, as well as Promtag Reversible Protein Tagging Agents and related accessories. By supplying tools for efficient protein handling, Impact Proteomics aims to enhance drug and biomarker discovery processes, allowing researchers to accelerate the development of therapeutics and diagnostics. The company's offerings are available for purchase online, reflecting its commitment to supporting the scientific community in advancing medical research.

Beta Hatch

Grant in 2018
Beta Hatch grows insect protein for animal feed. Nutrient balanced fertilizer is a sterile by-product of their process. Beta Hatch knows bugs better than anyone- they use their expertise in entomology to grow the most efficient and nutritious insects. They are currently farming mealworms from their urban farm in Seattle. They believe in changing food systems. Their goal is to develop the technology and knowledge that will make insects the next commodity crop.

Instapath

Grant in 2018
Instapath Inc. specializes in designing and developing a microscopy system that enhances the evaluation of cancer biopsies. The company’s technology allows for imaging biopsy samples at subcellular resolution immediately after removal, while also preserving the tissue for future analysis. This innovation aims to address a critical need, as over 7 million Americans undergo biopsy procedures annually, with a significant portion failing to provide accurate diagnoses, leading to costly repeat procedures. By improving rapid on-site evaluation of biopsies, Instapath’s system reduces the necessity for these repeat procedures, thereby increasing operating room efficiency and potentially boosting hospital revenue. Founded in 2017, Instapath is headquartered in New Orleans, Louisiana.

risQ

Grant in 2018
Developer of climate risk analytics platform designed to catalyze and inform systems-level adaptation to climate change. The company models the complex financial risks posed by weather change and translates them to actionable insights, empowers investors to better manage portfolios and allows cities to identify cost-benefit effective environment adaptation opportunities, enabling municipal debt stakeholders to leverage economic and physical sciences to drive altitude adaptation.
Living Ink Technologies is a biotechnology company that transforms algae into sustainable ink for printing an array of products.

Impactivo Consulting

Grant in 2017
Impactivo is a social impact consulting firm that specializes in the field of health and healthcare, childhood and education and philanthropy. They produce solutions that translate research and policy to action and build systemic, operational and strategic funding capacity. Impactivo offers a wide array of services in Strategic Funding, Financial Sustainability, and Program Management to support leaders at the forefront of social innovation in making strategy and organization decisions that lead to exceptional results. They are dedicated to the development of positions that improve the health status, educational attainment, and general wellbeing of the people of people who live in Puerto Rico and abroad.

InnoVein

Grant in 2017
InnoVein, Inc. is a medical device company based in San Carlos, California, focused on developing innovative solutions for vascular health. Founded in 2015, the company specializes in creating an implantable valve designed to regulate blood flow in the veins, particularly for elderly patients suffering from venous insufficiency. Their technology aims to address the challenges associated with this condition, improving the quality of life for affected individuals. As a venture-backed enterprise, InnoVein is committed to advancing cardiac and arterial health through its specialized medical devices.

Sironix Renewables

Grant in 2017
Sironix Renewables, Inc. is a Seattle-based company founded in 2016 that specializes in producing environmentally friendly ingredients for cleaning and personal care products derived from plants. The company focuses on the development of oleo-furan surfactant technology, which enables the production of plant-based detergents with fewer harmful chemicals and higher effectiveness. Sironix Renewables aims to create safer consumer products, offering alternatives that are free from harmful additives. Additionally, the company’s innovations have potential applications in various industries, including agricultural pesticides and oil spill remediation, reflecting its commitment to sustainability and safety in industrial consumer products.

Beta Hatch

Grant in 2016
Beta Hatch grows insect protein for animal feed. Nutrient balanced fertilizer is a sterile by-product of their process. Beta Hatch knows bugs better than anyone- they use their expertise in entomology to grow the most efficient and nutritious insects. They are currently farming mealworms from their urban farm in Seattle. They believe in changing food systems. Their goal is to develop the technology and knowledge that will make insects the next commodity crop.

risQ

Grant in 2016
Developer of climate risk analytics platform designed to catalyze and inform systems-level adaptation to climate change. The company models the complex financial risks posed by weather change and translates them to actionable insights, empowers investors to better manage portfolios and allows cities to identify cost-benefit effective environment adaptation opportunities, enabling municipal debt stakeholders to leverage economic and physical sciences to drive altitude adaptation.

Inquiry Technologies

Grant in 2015
Developer of a digital hiring platform intended specifically for fair and second chance labor pools. The company’s patented product and services support a dual-sided employer-employee training model for soft skills that is easily accessed and highly personalized, yet scalable at enterprise levels. Our model effectively identifies and matches employers with the best candidates from second and fair chance employees, provides a network of related resources, and trains either side with the skills needed to ensure the success of these placements. The platform saves employers time and money, dramatically improves the jobseeker’s odds of getting hired, helps fill jobs in areas of critical need, and reduces much of the stigma associated with portion of the workforce.
Innovation Accelerator is a software company based in Brookfield, Massachusetts, specializing in a cloud-based platform designed to enhance the innovation process for businesses. The company's technology facilitates the generation of diverse and high-quality ideas in a shorter timeframe, thereby making innovation more predictable across various business areas, including product development, marketing, and engineering. Its problem-solving application creates an interactive, real-time environment that supports remote teams in addressing business challenges through structured improvement processes. The technology is rooted in the research of co-founder Dr. Tony McCaffrey, a former Post-Doctoral Fellow at the University of Massachusetts, emphasizing the integration of human-machine interaction to optimize innovation outcomes.

Pivot Bio

Grant in 2015
Pivot Bio is a biotechnology company founded in 2010 and based in Emeryville, California, that focuses on enhancing crop nutrition through the use of engineered microbes. The company leverages its deep understanding of the plant microbiome, employing engineering principles and data science to map microbial dynamics and develop beneficial traits. Pivot Bio's proprietary ON Technology utilizes naturally occurring microbes to provide crops with essential nutrients, particularly nitrogen, which is crucial for growth. This innovative approach aims to replace synthetic nitrogen fertilizers, thereby reducing the environmental impact associated with conventional farming practices. By enhancing crops' ability to capture and metabolize atmospheric nitrogen, Pivot Bio seeks to lower farming costs, improve crop yields, and contribute to a sustainable agricultural future that benefits both the planet and food supply.

Polymer Braille

Grant in 2014
PBI is creating an interactive & refresh-able Braille display technology to connect 315 million visually impaired individuals.
Innovation Accelerator is a software company based in Brookfield, Massachusetts, specializing in a cloud-based platform designed to enhance the innovation process for businesses. The company's technology facilitates the generation of diverse and high-quality ideas in a shorter timeframe, thereby making innovation more predictable across various business areas, including product development, marketing, and engineering. Its problem-solving application creates an interactive, real-time environment that supports remote teams in addressing business challenges through structured improvement processes. The technology is rooted in the research of co-founder Dr. Tony McCaffrey, a former Post-Doctoral Fellow at the University of Massachusetts, emphasizing the integration of human-machine interaction to optimize innovation outcomes.

Inquiry Technologies

Grant in 2013
Developer of a digital hiring platform intended specifically for fair and second chance labor pools. The company’s patented product and services support a dual-sided employer-employee training model for soft skills that is easily accessed and highly personalized, yet scalable at enterprise levels. Our model effectively identifies and matches employers with the best candidates from second and fair chance employees, provides a network of related resources, and trains either side with the skills needed to ensure the success of these placements. The platform saves employers time and money, dramatically improves the jobseeker’s odds of getting hired, helps fill jobs in areas of critical need, and reduces much of the stigma associated with portion of the workforce.

MassChallenge

Grant in 2013
MassChallenge is a non-profit startup accelerator dedicated to supporting promising startups across various industries worldwide without taking equity. With locations in Boston, Israel, Mexico, Switzerland, Texas, and the UK, it offers expert mentorship, tailored curricula, and access to corporate partners, along with significant cash prizes for top startups. The organization fosters economic growth through programs like Bridge to MassChallenge in multiple countries and initiatives such as PULSE@MassChallenge, which focuses on digital health innovation. Additionally, MassChallenge has specialized programs like MassChallenge FinTech and MassChallenge HealthTech, designed to create partnerships between startups and established enterprises to drive innovation in financial services and digital health, respectively. To date, MassChallenge alumni have collectively raised over $2 billion in funding, generated approximately $900 million in revenue, and created over 65,000 jobs, underscoring its impact on the global innovation ecosystem.

MicroTech Instruments

Grant in 2013
Virginia Investor Portfolio Project - Q4 2021 (https://docs.google.com/spreadsheets/d/1MG-pIE-OQy6Bk3DyFqH2CA9_TWo7pA9rvn18zZxtgoA) MicroTech Instruments manufactures instruments for laser micromachining, coherent raman, multi-photon and terahertz imaging and spectroscopy applications. The company provides a wide range of equipment such as wire gride polarizers, polarization rotators, polyethylene lenses, and THz low pass filters. MicroTech Instruments was established in 1995 by Vladimir Kozlov in Eugene, Oregon.

Imprint Energy

Grant in 2013
Imprint Energy, Inc. specializes in developing and commercializing innovative zinc-based rechargeable battery technology. The company's flagship product, ZincPoly, overcomes traditional limitations associated with zinc batteries, enabling the creation of rechargeable solutions suitable for a variety of applications. Targeting the small portable electronics market, Imprint Energy focuses on sectors such as mobile accessories, wearable technology, and medical devices. The company's technology promises to deliver performance comparable to lithium batteries while significantly reducing costs and eliminating safety concerns associated with traditional battery designs. Founded in 2010 and headquartered in Alameda, California, Imprint Energy aims to meet the evolving energy demands of contemporary and future electronic devices.

Effimax

Grant in 2012
Effimax Solar is dedicated to reducing solar manufacturing costs and facilitating affordable solar power at the consumer level. They strive to promote environmentally safe manufacturing processes and become a leader in social responsibility.

Sustainability A to Z

Grant in 2012
Sustainability A to Z specializes in sustainability science including the implementation of green chemistry and engineering principles towards benign chemicals and formulations, carbon and water footprinting. The company provides research through implementation of a wide range of innovation services for its clients. The services they provide include green chemistry and engineering, computational toxicology, operational footprints, and stakeholder engagements. Sustainability A to Z was founded in 2007 by Dr. Julie Beth Zimmerman in Guilford, Connecticut.
Sustainable Innovations was founded in 2007 by Dr. Trent Molter to develop and manufacture innovative products based on a proprietary, low-cost, large format electrochemical platform that transforms waste gases and power into higher-value forms. Sustainable Innovations’ products serve critical energy and industrial applications having tremendous global commercial and societal value. Its revolutionary, high-pressure proton exchange membrane (PEM) technology builds upon prior private and public investment of over $1 billion in the low-carbon economy and places us in a unique position to address large robust markets having significant commercial and societal importance.

Polymer Braille

Grant in 2012
PBI is creating an interactive & refresh-able Braille display technology to connect 315 million visually impaired individuals.
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