National Science Foundation

Lura Health is a company that specializes in developing tooth-mounted sensors designed to monitor oral health through saliva analysis. Founded in 2016 and based in Cambridge, Massachusetts, Lura Health's wireless intra-oral sensors allow users to continuously track key diagnostic metrics related to their oral environment. The sensors are designed to sit comfortably on a single tooth and monitor oral acidity, transmitting data to a mobile application. This technology provides users with meaningful insights and instant feedback, empowering them to take control of their health and improve personal health management by setting and achieving health goals.

UCHU Biosensors develops a platform of tooth mounted sensors to effortlessly track health through saliva.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes proprietary technology to deliver therapeutic DNA directly to intestinal stem cells, aiming to address the underlying causes of diseases such as Familial Adenomatous Polyposis (FAP), a hereditary form of colorectal cancer that often necessitates invasive surgical procedures. By targeting these root causes, DNALite seeks to prevent disease progression rather than merely managing symptoms, offering a potentially transformative approach to treating gastrointestinal disorders, including colorectal cancer and Crohn's disease.

The Wrightguard specializes in the development of innovative smart mouthguards tailored for athletes. These mouthguards are equipped with advanced sensors and wireless communication technology that gather real-time biometric data, enabling the monitoring of both health and performance. This technology aims to enhance athlete safety by ensuring consistent placement and uniform thickness of shock-absorbing materials, providing effective protection during sports activities. Wrightguard's products offer an affordable dental solution, making it easier for athletes to prioritize their safety while competing.

SingletO2 Therapeutics is a biotechnology company founded in 2015 and based in New Providence, New Jersey. The company focuses on developing innovative treatments for periodontal disease by utilizing the unique properties of singlet oxygen. This advanced approach capitalizes on the bacteria-killing capabilities of singlet oxygen, enabling clinicians to effectively treat advanced stages of periodontal disease without the need for surgical intervention. Through its research and development efforts, SingletO2 Therapeutics aims to improve patient outcomes and transform the management of periodontal health.

Lura Health is a company that specializes in developing tooth-mounted sensors designed to monitor oral health through saliva analysis. Founded in 2016 and based in Cambridge, Massachusetts, Lura Health's wireless intra-oral sensors allow users to continuously track key diagnostic metrics related to their oral environment. The sensors are designed to sit comfortably on a single tooth and monitor oral acidity, transmitting data to a mobile application. This technology provides users with meaningful insights and instant feedback, empowering them to take control of their health and improve personal health management by setting and achieving health goals.

UCHU Biosensors develops a platform of tooth mounted sensors to effortlessly track health through saliva.

Hubly Surgical Inc. is a medical device company focused on enhancing the safety of neurosurgical procedures. Founded in 2018 and headquartered in San Francisco, California, with an additional office in Chicago, the company has developed an integrated electric drill system designed to replace traditional hand-cranked drills. This innovative technology aims to reduce the high complication rates associated with common neurosurgical procedures, which can fail up to 20% of the time. The drill system features advancements such as drilling guidance, plunge prevention, and catheter guidance, making it suitable for both operating rooms and emergent settings. By streamlining bedside intracranial access and decreasing reliance on traditional operating room environments, Hubly Surgical seeks to improve the overall safety and efficiency of neurosurgery.

Excise bias from routine elements of dental examinations by developing consensus-based automation using computer vision. Support payors by automating elements of their claims review process. Empower non-specialists with data-driven triaging to help patients efficiently navigate their provider network. Advance broader access to dental care by mobilizing remote screenings at drugstore kiosks and community health centers.

Mstatt, founded in 2018 and based in Cleveland, Ohio, focuses on the development of photonic technologies applicable across various sectors, including healthcare, aerospace, manufacturing, and defense. The company is particularly noted for its innovative, patent-pending Brillouin spectrometer system, which aims to revolutionize dentistry by facilitating the early detection of dental caries. This technology allows for timely interventions, reducing the necessity for invasive procedures such as cavity drilling. Mstatt's commitment to advancing photonic and biochemical technologies positions it as a significant player in enhancing diagnostic methods and treatment options within the dental care industry.

3D Health Solutions develops a novel 3D canine organoid model to study oral drug permeability and metabolism. The company is based in Ames, Iowa.

DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes proprietary technology to deliver therapeutic DNA directly to intestinal stem cells, aiming to address the underlying causes of diseases such as Familial Adenomatous Polyposis (FAP), a hereditary form of colorectal cancer that often necessitates invasive surgical procedures. By targeting these root causes, DNALite seeks to prevent disease progression rather than merely managing symptoms, offering a potentially transformative approach to treating gastrointestinal disorders, including colorectal cancer and Crohn's disease.

OsteoVantage, Inc. is a company focused on developing osteogenic spinal instrumentation technology to enhance surgical outcomes for spinal fusion procedures. Founded in 2012 and based in Fayetteville, Arkansas, OsteoVantage offers a product called OsteoHeal, designed specifically for treating spine injuries. The company's innovative technology aims to minimize pain, enhance mobility, and improve clinical results for individuals suffering from back injuries, fractures, degenerative diseases, and various orthopedic, craniomaxillofacial, and dental disorders. By integrating non-pharmacologic, osteoinductive capabilities into existing implantable instrumentation, OsteoVantage utilizes metal hardware for mechanical stabilization and anchoring, which delivers osteogenic electrical stimuli to the injury site, thereby promoting healing and recovery.

Neocis, Inc. is a company that specializes in the development and manufacturing of robotic guidance systems for dental implant procedures. Founded in 2009 and based in Miami, Florida, Neocis has created Yomi, a robotic device designed to enhance the precision of dental implant placements. Yomi integrates computer imagery from CT scans with surgical planning, providing multi-sensory feedback to dental surgeons during procedures. The device is commercially available in the United States and has received clearance from the U.S. Food and Drug Administration. Neocis focuses on collaborating with dental professionals to address surgical challenges and improve patient care through advanced technology, promoting a minimally invasive approach that facilitates faster surgery and recovery.

Nasseo, Inc. is a medical device company based in Peoria, Arizona, specializing in the development and manufacturing of dental and orthopedic implant systems. Established in 2012, Nasseo focuses on providing innovative treatment options for patients with circulatory issues, such as diabetics and smokers. The company has pioneered a next-generation nanotube implant surface technology known as TiArray, which enhances the bonding and healing processes of implants. This technology modifies the natural oxide layer of various implant materials to create a uniform nanotube array, resulting in improved anti-inflammatory, anti-bacterial properties, and better soft tissue responses. Nasseo's first product, the TiArray Dental Implant, has received FDA approval, and the company plans to conduct post-market human clinical trials. Additionally, Nasseo is in the development phase of a Titanium-PEEK hybrid interbody fusion device that will also utilize TiArray technology, further expanding its product offerings in the medical device market.

OsteoVantage, Inc. is a company focused on developing osteogenic spinal instrumentation technology to enhance surgical outcomes for spinal fusion procedures. Founded in 2012 and based in Fayetteville, Arkansas, OsteoVantage offers a product called OsteoHeal, designed specifically for treating spine injuries. The company's innovative technology aims to minimize pain, enhance mobility, and improve clinical results for individuals suffering from back injuries, fractures, degenerative diseases, and various orthopedic, craniomaxillofacial, and dental disorders. By integrating non-pharmacologic, osteoinductive capabilities into existing implantable instrumentation, OsteoVantage utilizes metal hardware for mechanical stabilization and anchoring, which delivers osteogenic electrical stimuli to the injury site, thereby promoting healing and recovery.

FlexDex Inc. specializes in the development of minimally invasive surgery (MIS) devices, focusing on enhancing surgical precision and dexterity. The company's innovative platform technology allows surgeons to translate their hand, wrist, and arm movements from outside the patient into corresponding movements of an end-effector within the patient's body. This capability improves the functionality of MIS instruments and endoscopes, making procedures safer and more efficient. FlexDex serves healthcare professionals through a network of distributors both in the United States and internationally. Founded in 2010 and based in Brighton, Michigan, FlexDex continues to advance the field of minimally invasive surgery.

4WEB Inc. develops and manufactures 3D-printed titanium implant devices for the healthcare industry. The company’s products for spine, foot, and ankle include Posterior Spine Truss System, Anterior Spine Truss System, Cervical Spine Truss System, Osteotomy Truss System, and Lateral Spine Truss System. 4WEB Inc. was founded in 2008 and is based in Frisco, Texas.

Manufacturer of mouthguards designed to protect the teeth of athletes. The company's mouthguards are made up of non-compressible thermo-polymer to permit the natural flow of air and saliva to empower athletes to talk normally, breathe naturally, and stay hydrated during the game, enabling users to protect their teeth during amateur sports activities and reduce dental injuries during intubations.

3Derm Systems, Inc. is a Boston-based company focused on enhancing dermatological care through innovative imaging technology. Founded in 2011, it provides a handheld skin imager and cloud-based software that enables users, including non-dermatologists, to capture high-resolution 3D images of skin lesions. This system allows patients to monitor their skin conditions from home, significantly reducing the need for frequent in-office visits, which can be both costly and inconvenient. By facilitating remote reviews of these images by trained dermatologists, 3Derm ensures timely monitoring of potential skin cancers and other skin issues. This approach not only cuts down on wait times but also helps manage the healthcare resources more efficiently. The company's mission is to improve access to dermatological care and provide a cost-effective solution that empowers patients while maintaining high diagnostic standards. As of August 2020, 3Derm operates as a subsidiary of Digital Diagnostics, Inc.

FlexDex Inc. specializes in the development of minimally invasive surgery (MIS) devices, focusing on enhancing surgical precision and dexterity. The company's innovative platform technology allows surgeons to translate their hand, wrist, and arm movements from outside the patient into corresponding movements of an end-effector within the patient's body. This capability improves the functionality of MIS instruments and endoscopes, making procedures safer and more efficient. FlexDex serves healthcare professionals through a network of distributors both in the United States and internationally. Founded in 2010 and based in Brighton, Michigan, FlexDex continues to advance the field of minimally invasive surgery.

Arphion creates non-invasive diagnostics for oral cancers and other benign diseases. They utilize miRNA markers from cheek swabs to diagnose oral squamous cell carcinomas. Arphion provides its clients with tests as a Laboratory Developed Test (LDT) through a CLIA-certified laboratory to market their products without submission to the FDA for approval or clearance. Arphion was founded by Dr. Guy Adami, Ph.D. in Illinois, United States.

4WEB Inc. develops and manufactures 3D-printed titanium implant devices for the healthcare industry. The company’s products for spine, foot, and ankle include Posterior Spine Truss System, Anterior Spine Truss System, Cervical Spine Truss System, Osteotomy Truss System, and Lateral Spine Truss System. 4WEB Inc. was founded in 2008 and is based in Frisco, Texas.

Manufacturer of mouthguards designed to protect the teeth of athletes. The company's mouthguards are made up of non-compressible thermo-polymer to permit the natural flow of air and saliva to empower athletes to talk normally, breathe naturally, and stay hydrated during the game, enabling users to protect their teeth during amateur sports activities and reduce dental injuries during intubations.

OsteoVantage, Inc. is a company focused on developing osteogenic spinal instrumentation technology to enhance surgical outcomes for spinal fusion procedures. Founded in 2012 and based in Fayetteville, Arkansas, OsteoVantage offers a product called OsteoHeal, designed specifically for treating spine injuries. The company's innovative technology aims to minimize pain, enhance mobility, and improve clinical results for individuals suffering from back injuries, fractures, degenerative diseases, and various orthopedic, craniomaxillofacial, and dental disorders. By integrating non-pharmacologic, osteoinductive capabilities into existing implantable instrumentation, OsteoVantage utilizes metal hardware for mechanical stabilization and anchoring, which delivers osteogenic electrical stimuli to the injury site, thereby promoting healing and recovery.