WiSys Technology Foundation works hand in hand with the University of Wisconsin System to support research and technology development, link campus innovators with industry leaders and speed technology transfer through patent and licensing activities.
OmniVis operates a portable pathogen detection platform that allows for the rapid and accurate measurement of pathogens in various environments, particularly in food processing facilities. The company provides an easy-to-use hardware device in conjunction with disposable test kits that can analyze swabs or liquid samples. This streamlined process reduces the pathogen detection time to just 30 minutes, making it both efficient and cost-effective for health organizations. By focusing on user-friendly technology, OmniVis aims to enhance the accuracy of pathogen detection while ensuring affordability and simplicity in its application.
Protabit engineers proteins for industrial, agricultural, and healthcare applications. Its platform technology is being developed via a strategic partnership with the Monsanto Company and the California Institute of Technology. Protabit’s protein engineering approach combines computational modeling with high-throughput screening and directed evolution to expand the diversity of protein sequences that can be explored to produce novel proteins.
BioSuperior is a preclinical stage biotherapeutics company developing cost-effective, non-invasive, and easily accessible technologies to cure lung disease and repair damaged lung tissue. They have bio-engineered a novel synthetic pulmonary surfactant prototype, BioSurf, an essential biomaterial required for breathing and having direct therapeutic effects that will be used to deliver potent drugs that restore normal lung function.
Brainsoft specializes in the development of technologies that leverage human brainwaves to control objects and analyze the relationship between brain activity and emotional and intellectual states. The company creates innovative interfaces that enable intuitive navigation, allowing users to interact with devices based on their mental and emotional conditions. By focusing on the interception and analysis of brainwaves, Brainsoft aims to support researchers in advancing their understanding of brain activity, ultimately benefiting society through improved insights into human cognition and behavior.
NovoClade is a synthetic biology company focused on developing environmentally friendly solutions for insect control and invasive species eradication. The company utilizes gene-editing technology to create sterile mosquito populations, aiming to mitigate the spread of diseases carried by these insects. By offering chemical-free pest control alternatives, NovoClade provides clients with innovative formulas that effectively reduce disease transmission without harming the environment. Through their advancements in genetic bio-control, NovoClade addresses critical public health challenges while promoting sustainable practices in pest management.
Oculogenex is a biopharmaceutical company based in La Habra, California, established in 2020. The company specializes in developing gene therapies specifically aimed at treating retinal disorders. Its innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced damage, which is a contributing factor to macular degeneration. By focusing on these therapies, Oculogenex aims to enhance the detection and treatment of various retinal disorders, ultimately supporting researchers in advancing novel drug solutions in this critical area of healthcare.
Aqua Science offers a global platform of technologies and fast and reliable solutions for the testing and treatment of water. They provide research and development, custom reagent and kit manufacture, product assembly, lyophilization services, and contract manufacturing services.
Uniphage is a biotech company that eliminates bacterial infections by combining the power of bacteriophages with artificial intelligence. Their first target disease is citrus greening, an incurable and debilitating disease that costs the United States more than $2 billion each year. Uniphage created the first commercially effective models for computationally predicting safe bacterial viruses against target bacterial infections, as well as discovered a variety of targets. This enables them to deliver new antimicrobial, safe, and precise products to market much more quickly.
Ezrabio is a biotechnology company that specializes in RNA adenylation technology, facilitating ribosome profiling across diverse biological samples. By offering rapid cDNA library construction and streamlined services from sample preparation to deep sequencing, Ezrabio empowers researchers and medical professionals to uncover hidden coding potential, analyze translational responses, identify tumor-associated antigens, and inform mRNA therapeutics. Their innovative approach simplifies complex processes, making it easier for scientists to conduct critical research in genetics and molecular biology.
Canomiks provides a genomics, bioinformatics and AI-based Product Superiority Platform that enables companies within the functional food and beverage, dietary supplement and skincare industries to create safe and efficacious products. Canomiks' long-term vision is to make food as medicine a reality.
Iaso Therapeutics develops vaccines to improve human health and cure diseases. The company was founded in 2018 and is based in East Lansing, Michigan.
Developer of a photo-bioreactor system intended for algae cultivation. The company's system is composed of a metal support cage, a plastic bladder containing culture volume, and a sterile harvest apparatus for the continual collection of pre-concentrated culture, equipped with both pH and temperature control options, enabling production facilities to reduce their carbon footprint and maintain a low rate of water consumption, in order to minimize their impact on the local and global environment.
Acrigen Biosciences focuses on enhancing the safety and efficacy of gene editing technologies, particularly those based on the CRISPR-Cas system. Founded in 2019 and headquartered in Berkeley, California, the company develops innovative solutions that aim to produce effective in vivo drug therapies to combat various diseases. Acrigen's proprietary technologies include Acro proteins that regulate the CRISPR-Cas gene editing process and an advanced bioinformatics discovery software platform that identifies suitable CRISPR systems for human therapeutic applications. Through these advancements, Acrigen Biosciences seeks to improve the precision, efficacy, and safety of genetic therapies, ultimately contributing to the potential prevention and cure of debilitating diseases.
UCHU Biosensors develops a platform of tooth mounted sensors to effortlessly track health through saliva.
InvVax, Inc. develops and commercializes influenza vaccine that prevents pandemics. It focuses on identifying influenza vaccines for HIV, Hepatitis B, and Hepatitis C. The company was founded in 2012 and is based in Los Angeles, California.
Auctus Biologics is a pre-clinical biotechnology company focused on developing antibody mimetics for therapeutic and diagnostic uses. By engineering a ribose-binding protein, the company aims to create a scaffold that binds clinical targets with an affinity comparable to monoclonal antibodies while addressing the limitations associated with traditional antibodies. These limitations include instability and the need for costly cold-chain logistics, which can hinder their effectiveness in extreme environments such as the gastrointestinal tract. Auctus Biologics' innovative approach allows for treatments that are not only more resilient, capable of withstanding conditions like repeated boiling cycles, but also more accessible and cost-effective for patients. This advancement may significantly enhance the delivery of advanced medical therapies.
PathOtrak, LLC specializes in developing food safety testing kits that facilitate the rapid detection of pathogens, such as Salmonella and E. coli, in food products. Founded in 2016 and located in College Park, Maryland, the company employs innovative microfiltration technology in its sample-preparation kits to significantly reduce testing time from days to hours. This advancement not only enhances food safety but also allows producers to release products more quickly, improving the balance between shelf life, profitability, and safety in the food industry. PathOtrak's solutions are validated through extensive testing and analysis, addressing the critical needs of various stakeholders involved in ensuring a safe food supply.
Oncurie specializes in developing targeted radionuclide therapies aimed at treating metastatic cancer. The company employs innovative molecular radionuclide technology to deliver radionuclides selectively to metastatic tissues, enhancing treatment efficacy. By focusing on this advanced therapeutic approach, Oncurie seeks to provide healthcare providers with the tools needed to effectively cure patients suffering from breast cancer and other metastatic conditions.
DNALite Therapeutics, Inc. is a biopharmaceutical company focused on developing gene therapy treatments specifically for the gastrointestinal tract. Founded in 2016 and based in San Francisco, California, the company utilizes proprietary technology to deliver therapeutic DNA directly to intestinal stem cells, aiming to address the underlying causes of diseases such as Familial Adenomatous Polyposis (FAP), a hereditary form of colorectal cancer that often necessitates invasive surgical procedures. By targeting these root causes, DNALite seeks to prevent disease progression rather than merely managing symptoms, offering a potentially transformative approach to treating gastrointestinal disorders, including colorectal cancer and Crohn's disease.
MBF Therapeutics, Inc. is a clinical-stage veterinary oncology company dedicated to developing innovative therapies for dogs and cats with cancer. The company's portfolio includes targeted immunotherapies and small molecule drugs designed to disrupt tumor cell metabolism while sparing normal healthy cells. Notable products in development include MBFT-101, a combination therapy for sarcomas and lymphoma that merges a polyamine transport inhibitor with a potent enzyme inhibitor, and MBFT-102, an immunotherapy based on the tumor suppressor mda-7/IL24, which has shown promise in human cancers. Additionally, MBF Therapeutics is exploring gene-based immunotherapeutic vaccines, aiming to revolutionize cancer treatment and infectious disease prevention in companion animals and livestock. The company collaborates with the Lankenau Institute for Medical Research and is headquartered in Ambler, Pennsylvania.
ChloBis Water specializes in innovative electrochemical technologies, specifically the development of a desalination battery. This technology integrates energy storage with the removal of sodium and chlorine from saltwater. The battery is constructed using bismuth as a chloride-storage electrode and sodium as a sodium-storage electrode, allowing it to efficiently desalinate water while simultaneously storing and releasing energy through the manipulation of salt ions. By addressing the challenges at the intersection of water and energy, ChloBis Water offers a solution that enhances energy efficiency and contributes to sustainable water management.
Rubi Laboratories develops technology that manufactures carbon-negative textile. It uses sustainable solutions to turn carbon emission into natural fibers. Rubi Laboratories is based in California, USA.
Synvivia makes ON-OFF switches for genetically engineered organisms. These protein switches are controlled by small molecules. By installing these switches into an organism, Synvivia creates engineered organisms that can be controlled with small molecules.
InsectaPel specializes in biobased insect repellent products designed for textiles, focusing on providing effective solutions to prevent blood-sucking insects from biting humans. The company’s innovative extended-release technology enhances the functionality of fabrics, ensuring long-lasting protection while adhering to regulatory standards. By offering sustainable and cost-effective alternatives, InsectaPel aims to transform the market for insect repellents, addressing both consumer needs and public health concerns related to insect-borne diseases.
Spekciton Biosciences specializes in biophotonic measurement systems and services aimed at enhancing agricultural performance and sustainability. The company develops innovative technologies that enable the rapid and precise detection of plant stress and viability, providing farmers with essential insights for improving crop management. Additionally, Spekciton offers biosensors designed to quickly identify soil and water contamination, supporting environmental health and agricultural productivity. Through its advanced measurement solutions, the company contributes to a better understanding of bioprocesses, ultimately aiding in the cultivation of resilient and sustainable crops.
BioSapien is a biotech startup that focuses on developing a 3D printed drug delivery platform to provide FDA approved drugs. The startup's device allows chemotherapy to be delivered intravenously through a controlled drug release and enables physicians to reduce harmful side-effects and dramatically reduce costs. BioSapien was established in 2018 and is based in New York.
Huue, formerly known as Tinctorium Inc., is a biotechnology company based in Berkeley, California, specializing in sustainable indigo dyeing solutions for the textile and fashion industry. Founded in 2018, the company utilizes a unique technology that mimics natural plant processes within microbes to produce indigo dye. This innovative approach significantly reduces chemical usage in the denim supply chain, offering an environmentally friendly alternative for denim production. By harnessing the power of biotechnology, Huue aims to provide the fashion industry with sustainable coloring options that rely on renewable resources, contributing to a more eco-conscious approach in textile manufacturing.
Aracari's 3D Vascularized Micro-Organ platforms are designed to increase the efficiency of the drug discovery pathway by significantly enhancing the biological authenticity of pre-clinical testing platforms.
Felix Biotechnology, founded in 2019 and based in San Francisco, California, is focused on developing biotherapeutics aimed at addressing microbial challenges in human health, particularly antibiotic-resistant strains of bacteria and fungi. The company aims to accelerate the deployment of innovative treatments for infectious diseases, enabling healthcare professionals to manage these urgent health threats effectively. Through its targeted approach, Felix Biotechnology seeks to provide precise and effective solutions to combat the growing issue of antibiotic resistance.
Fortiphyte offers agricultural protection products that help to protect crops from disease and reduce fungicide use. The company was founded in 2017 and is based in Berkeley, California.
Labby Inc. is a technology company based in Cambridge, Massachusetts, founded in 2017. It specializes in developing a smartphone-based wireless optical spectrometer for testing milk composition, primarily serving farmers and dairy processors. The company's AI-driven cloud platform translates raw optical data into actionable insights for individual animals and entire herds, facilitating rapid mastitis detection and timely intervention. In addition to its primary focus on dairy, Labby's technology has applications in the beer and wine production industry, offering tools for counterfeit detection, quality control, and serving as a virtual brewmate for homebrewers. The platform also aids in monitoring spoilage along the supply chain, detecting adulterants and contamination, and tracking harvest cycles while providing meteorological data mapping for farm-level analytics.
Biochip Labs, founded in 2019 and headquartered in Cleveland, Ohio, specializes in laboratory testing services for blood disorders, particularly sickle cell disease and thalassemia. The company offers a variety of proprietary microfluidic biomarker assays that assess blood cell adhesion, red blood cell deformability, whole blood rheology, and endothelialized microfluidics. These assays are designed to evaluate the efficacy of emerging targeted and curative therapies, allowing clinicians to effectively monitor patient responses to treatment. By focusing on accurate and high-quality testing, Biochip Labs aims to advance the understanding and management of blood disorders.
xMD Diagnostics operates in the healthcare industry focusing on biotechnology business. The company was formerly known as Bay Resources Development Group. The company is headquartered in Annapolis, Maryland. xMD Diagnostics uses high-throughput microdissection technology for the diagnosis of cancer.
SIEV Technologies, founded in 2020 and based in Fayetteville, Arkansas, specializes in catalytic membrane technology aimed at transforming biomass waste into valuable bio-products. The company's innovative approach involves designing and fabricating a tunable catalyst that functions similarly to natural enzymes, achieving high selectivity and conversion rates. Unlike traditional enzymes, SIEV's technology can operate at elevated temperatures with greater efficiency, allowing clients to harness a diverse array of biomass sources for the production of sustainable chemicals. This advancement positions SIEV at the forefront of the bio-products sector, promoting environmental sustainability through the effective utilization of waste materials.
Developer of a novel approach augmented low-pass long-read NGS designed to facilitate the detection of complex genetic variation. The company's platform processes long-read ngs raw data DNA sequences, enabling clients to minimize time spent on variant calling and have resolved variants, with a reduction of cost, and improved tat and scalability.
Developer of gastrointestinal therapeutic device designed for the alleviation of postoperative ileus and the restoration of gastrointestinal motility. The company's device aims to revolutionize medical science by using bioelectronic medicine for the treatment of diseases and injuries incurable pharmaceutically and is capable of developing miniaturized implantable device, while retaining sophisticated functionality with various electrode shape and number, enabling clinicians to treat diseases and injuries through neuromodulation.
Zeteo Tech LLC is a defense technology company that focuses on researching, developing, prototyping, and commercializing innovative solutions in the fields of biodefense and medical devices. Founded in 2013 and headquartered in Maryland, the company specializes in creating advanced instrumentation, such as fieldable biological mass spectrometers that can identify airborne microbes, proteins, and lipids. This technology aids in screening for infectious diseases and other biological threats, allowing healthcare professionals to automate detection in operational environments while reducing costs. Additionally, Zeteo Tech's portfolio includes air and water purification systems, portable power solutions, and technologies for CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosives) detection and decontamination. The company serves a diverse clientele, including national security agencies, private enterprises, and government organizations within the United States.
Infusense is a platform biosensor to measure propofol levels in patients undergoing anesthesia and sedation.
TheraCea Pharma is a biotechnology company that develops precision medicine to help people with neurological disorders. TheraCea Pharma, a University of Arizona spin-off based in Tucson, developed and licensed radiochemistry technology that allows for high-efficiency and rapid fluorine-18 radiolabeling of biomolecules for clinical and research applications.
Kodikaz Therapeutic Solutions is focused on advancing cancer treatment by developing targeted therapies aimed at eradicating cancers while minimizing side effects. The company utilizes its innovative Zip-Code™ Technology platform, a first-in-class delivery system that facilitates cell-specific genomic transfer for both RNA and DNA applications. Rooted in discoveries from human cancers, this platform addresses the limitations associated with traditional viral delivery methods, providing a more effective and safer alternative. Kodikaz's research generates valuable in-vitro and in-vivo data across various oncological applications, including pancreatic, myeloma, and colorectal cancers, supporting the development of curative gene transfer technologies.
Biko Biolabs is a research company founded in 2020 and located in Somerville, Massachusetts, that focuses on the intersection of plastic waste and regenerative agriculture. The company aims to address research and development gaps related to sustainability and self-sufficiency in traditionally marginalized communities. By providing resources to innovators, Biko Biolabs fosters the creation of new economic opportunities and trains emerging local scientists and engineers. The company emphasizes impactful research that is closely aligned with the specific needs of the communities involved, enabling tailored scientific practices and technologies that directly address fundamental community challenges.
BirdHabitatBot develops a robotic system to remove invasive plant species from the environment. Unpiloted aerial systems images from the company's drones are used to map, monitor, and remove non-native invasive plants in the deciduous forest that are significantly contributing to the degradation of forest habitat, allowing natural resource professionals to manage understory invasive shrub species and improve habitat for native plants and wildlife.
NanoSpy, Inc. was founded in 2017 to establish the new state-of-the-art in rapid pathogen detection. Using proprietary and patent-pending technologies, we leverage our expertise in biomedical engineering, microbiology, nanomaterials, and mechanical engineering to dramatically simplify the detection process with a new paradigm in biosensor platforms. Sensitivity, specificity, and speed now are combined in one convenient test that delivers results fast! In 20 minutes, NanoSpy biosensors can detect a single targeted pathogen at 5 CFU/mL or less from common buffer samples taken right at the point of detection. No time-consuming enrichment process. No environmentally hazardous reagents. No laboratory requirements. Translation: No time wasted. No decisions delayed.
Developer of industrial enzymes intended to provide high value enzymes and chemical entities to businesses. The company develops combination of disparate disciplines to overcome problems that are not amenable to throughput screening methodologies in order to discover new, high value enzymes and chemical entities, enabling organizations to produce and market chemical products and processes through contract or in partnership .
TRGel develops glucose-based biopolymers that can be used instead of calcium alginate for encapsulation. The company was founded in 2010 and is based in Irvine, California.
Frontier Bio Corporation is a biotechnology company based in Oakland, California, that specializes in the development and manufacturing of advanced bioprinting technologies. Founded in 2018, the company has created a unique bioprinter known as FLUX-1, which integrates traditional bioprinting methods with electro-hydrodynamic printing. This innovative approach allows for the precise printing of biological materials at the micro and nanoscale while preserving high cell viability. The FLUX-1 bioprinter is utilized for a range of applications, including the fabrication of tissues such as skin, cartilage, and bone, as well as for drug toxicity testing, tissue implants, drug screening, disease modeling, and the production of prosthetics. Frontier Bio's technology represents a significant advancement in the field of bioprinting, offering new possibilities for medical and research applications.
Developer of neurodiagnostic technologies intended to commercialize blood testing products. The company provides critical data that can be useful in diagnosis, monitoring and assessing therapeutic responses that help to make discoveries for brain health and diseases, enabling pharmaceutical companies and researchers to drug discovery and conduct studies in brain disease.
Nano PharmaSolutions improves the bioavailability of insoluble drugs using innovative, revolutionary nanoformulation. Nano PharmaSolutions offers a phase-transition technology platform that can reliably enhance the solubility of BCS 2 and BCS 4 APIs without the use of excipients (e.g. large volumes of volatile solvents) used in such processes as spray dry dispersion, hot-melt extrusion, and emulsification. Their patented technology platform deposits vaporized API onto the surface of a carrier molecule which is further processable into the full spectrum of existing dosage forms.
Developer of virus-resistant live bacterial products designed to modulate the human microbiome. The company targets the viral components of the gut microbiome to treat disease and focus on healthy gut bacteria and their predatory phages to engineer resistant strains, and also develops a new class of live biotherapeutics, enabling medical science professionals to specifically target phages or viruses with a specific affinity for inducing lysis.
SingletO2 Therapeutics is a biotechnology company founded in 2015 and based in New Providence, New Jersey. The company focuses on developing innovative treatments for periodontal disease by utilizing the unique properties of singlet oxygen. This advanced approach capitalizes on the bacteria-killing capabilities of singlet oxygen, enabling clinicians to effectively treat advanced stages of periodontal disease without the need for surgical intervention. Through its research and development efforts, SingletO2 Therapeutics aims to improve patient outcomes and transform the management of periodontal health.
Novel Farms, Inc. specializes in the production of cell-based meat products aimed at ethical consumers. Founded in 2020 and headquartered in Berkeley, California, the company focuses on developing innovative 3D bioscaffolds that are cruelty-free, cost-effective, and customizable. These bioscaffolds facilitate the co-culturing of fat and muscle cells, essential for achieving the desired marbling and texture in cell-based meats. By leveraging synthetic biology, Novel Farms seeks to enhance the structure and flavor profiles of these products, ultimately aiming to recreate the taste and texture of traditional meats such as Jamon Iberico. The company's mission is to transform cell-based meat into a premium culinary experience for the next generation of conscious eaters while addressing key challenges in the cellular agriculture industry.
Theromics Inc. develops cell therapies. It offers HeatSYNC Gel, a thermal accelerant (TA) that augments MW and RF energy by increasing local tissue electrical conductivity in a reproducible and effective manner. The company’s TA absorbs microwave energy effectively preventing heat loss caused by blood flow in large vessels adjacent to ablation zone; optimizes the shape of the ablation zone into a circle making the ablation volume predictable; and produces a larger ablation area making it easier to target the tumor center and with 3-D modeling optimizes antenna guidance into tumor mass. Theromics Inc. was founded in 2016 and is based in West Bridgewater, Massachusetts.
Boston Meats, Inc. produces alternative meat products using proteins. It also develops fiber production technology to produce meats using natural proteins. The company was founded in 2020 and is based in Somerville, Massachusetts.
Hermes Life Sciences develops solutions to improve the accuracy and accessibility of blood testing at the point of care. The company was founded by Sasank Vemulapati.
Frugi Biotechnology is a synthetic biology company based in Ames, Iowa, founded in 2020. The company specializes in developing modular, paper-based diagnostics aimed at managing viral outbreaks. Frugi's services include creating custom cell-free extracts that facilitate the building and testing of learn cycles for clients involved in protein biomanufacturing and protein discovery. This allows clients to detect pathogens in a simplified and cost-effective manner, enhancing the capabilities for outbreak management and response.
BioSense8 develops biosensors for use in human and animal healthcare, and environmental wellness. The company was founded in 2020 and is headquartered in Boston, Massachusetts.
Sequitur Health develops a blood biomarker monitoring device with the aim of saving, extending, and improving people's lives. The company was founded in 2019 and is headquartered in Scottsdale, Arizona.
Modular Science focuses on automating the majority of processes in vegetable farming through the development of specialized modular machines. These farming bots are designed to significantly reduce manual labor by handling various tasks involved in food production, thereby enhancing efficiency and sustainability. By leveraging automation, Modular Science aims to promote healthier agricultural practices that benefit both humans and the environment.
Drive Therapeutics is a biotechnology company focused on enhancing treatments for retinal diseases. The company is developing therapeutics specifically aimed at addressing wet age-related macular degeneration and diabetic retinopathy, including diabetic macular edema. Through its innovative approach, Drive Therapeutics aims to provide more effective solutions for patients suffering from these serious eye conditions.
Minnowtech is an aquaculture technology company based in Baltimore, Maryland, focused on improving shrimp farming through innovative software solutions. The company has developed a non-invasive imaging platform that leverages artificial intelligence and image analysis to accurately estimate shrimp abundance and biomass in ponds. This technology allows shrimp farmers to optimize feeding regimes, enhance harvests, and manage risks associated with juvenile shrimp health. By addressing critical challenges in the aquaculture industry, such as the assessment of shrimp growth and optimal harvest times, Minnowtech aims to improve the livelihoods of farmers while contributing to global food security and the sustainability of marine environments.
Paramita Therapeutics is a San Diego-based biotech company established in 2018 that specializes in developing innovative therapeutics for cancer and infectious diseases. The company employs a patented multi-functional chemical platform to facilitate the rapid transition of new therapies from the laboratory to clinical settings. By focusing on multivalent drug conjugates derived from recognized and approved molecules with established safety and toxicology profiles, Paramita Therapeutics aims to enhance patient access to effective cancer treatments and dual-function therapeutic and vaccine products.
ZiTechnologies provides end product pellets with reduced chlorine content that are suitable for power and heat applications. They offer pellets that can be used to replace coal.
Eden Concepts is a precision agriculture technology development and consulting firm based in Lenoir City, Tennessee, founded in 2018. The company focuses on enhancing farm productivity for small farmers by providing innovative solutions for vegetable and specialty crop cultivation. Its precision systems are designed to prepare and plant germinated seeds, replacing traditional methods of growing and transplanting seedlings. This approach not only improves soil health but also offers flexibility in crop selection, thereby helping farmers reduce labor costs and streamline energy-intensive farming processes.
Developer of recombinant protein-based materials designed to mimic those naturally found in this environment. The company's products have core protein biometrics composed of a simple modular design, translated into a system that forms fractal-like porous networks with material properties after injection and exposure to body heat, enabling medical researchers to get the required bio-compatible materials used in tissue engineering and regenerative medicine.
Stellate DNA, founded in 2020 and headquartered in Cambridge, Massachusetts, specializes in developing proprietary DNA donor technology for the synthesis and production of single-strand DNA donors. The company employs a clonal synthesis approach rather than traditional chemical methods, allowing for the manufacture of customizable gene knock-in payloads. This platform enables production at microgram to milligram scales while maintaining controlled costs, thereby assisting medical professionals in achieving minimal mutation rates and ensuring sequence uniformity.
Desert Valley Tech, founded in 2018 and based in Mesa, Arizona, specializes in developing cold chain storage systems designed to preserve temperature-sensitive items such as blood, pharmaceuticals, biologics, and organs. The company's innovative system maintains pre-set temperatures while optimizing power consumption, providing customizable modular storage solutions suited for various scenarios. This technology enhances the ability of medical professionals to ensure the safe transport and storage of critical medical supplies, ultimately improving survival rates in challenging and remote medical environments.
Avior Bio is a clinical-stage pharmaceutical company focused on developing innovative treatments for neurological conditions and pruritus in patients with liver disease. The company utilizes its proprietary Speedit™ Transmucosal Film Technology, which allows for effective drug delivery by bypassing first-pass metabolism and minimizing the production of glucuronide metabolites excreted by the kidneys. This technology aims to provide significant relief from various symptoms, including insomnia, anxiety, depression, and excoriation. With a strong management team, an experienced advisory board, and dedicated scientists, Avior Bio is well-positioned to deliver safe and effective therapeutic solutions to improve patient outcomes.
Amber Agriculture, Inc. is a technology company based in Chicago, Illinois, founded in 2016. The company specializes in Internet of Things (IoT) solutions designed for the agricultural sector, focusing on the automation of grain storage monitoring and management. By providing sensor and analytics technology, Amber Agriculture enables farmers to effectively manage, protect, and market their grain. The firm was established by founders with backgrounds in both agriculture and technology, positioning it at the forefront of automation innovations in the industry. Its initial product is an IoT self-install kit aimed at automating key processes for farmers, enhancing efficiency and productivity at the farm level.
Tacit Therapeutics is a biotechnology company focused on developing RNA-targeted treatments to address genetic diseases. Founded in 2021 and based in South San Francisco, California, the company utilizes pre-existing components of human cells to create innovative, non-immunogenic methods for repairing mutated genes. By offering a broadly applicable approach to gene modification, Tacit Therapeutics aims to provide effective solutions for genetic conditions that were previously deemed untreatable, thereby enabling advancements in the treatment of devastating diseases.
Operator of a life science platform intended for democratizing advanced single-cell assays. The company's novel nano vial platform allows the rapid compartmentalization and analysis of millions of single cells to probe biological functions such as secreted proteins, enabling biotech labs and clients to develop higher-performing therapies for cancer, autoimmune conditions, and infectious diseases.
Gate Scientific makes products that enable great research and improve healthcare decisions by bringing to market intuitive solutions that simplify complex problems. By bringing to market intuitive solutions that simplify complex problems, they allow for the latest technologies to benefit more people.
Repela Tech is focused on commercializing an innovative, eco-friendly marine antifoulant designed to prevent biofouling on ships. The company has developed a groundbreaking antifouling coating that aims to match the performance of traditional copper-based paints while avoiding their toxic effects. Utilizing non-biocide marine coating technology, Repela offers a hydrogel coating and custom-engineered primer that effectively resist marine micro and macro-organisms, including Ulva zoospores, diatoms, and mussels. This approach provides clients with a safe and effective solution for maintaining the integrity and performance of their vessels in aquatic environments.
Operator of an agricultural biotechnology company committed to developing and producing allergen-free peanuts. The company develops its agricultural products using technology like genomics, proteomics, plant tissue culture and plant propagation, providing consumers with high-value agricultural products that enhance and save human lives.
NellOne Therapeutics, Inc. is a regenerative medicine company based in Oak Ridge, Tennessee, focused on developing and commercializing protein therapeutics aimed at restoring cardiac muscle mass and function in patients recovering from myocardial infarction and congestive cardiac failure. Established in 2007 and spun out from the U.S. Department of Energy's Oak Ridge National Laboratory, NellOne's foundation is rooted in research conducted by Dr. Cymbeline Culiat, who identified the therapeutic potential of the Nell1 gene pathway in tissue regeneration. The company’s primary goal is to translate scientific discoveries into clinical applications that improve recovery outcomes for individuals affected by heart conditions.
Precision Theranostics is a biotechnology company based in Baltimore, Maryland, founded in 2019. The company focuses on developing prognosis-based intervention strategies aimed at the early detection and treatment of fatal diseases. Its innovative platform is designed to estimate disease progression, particularly for respiratory diseases and age-related disorders. By creating novel diagnostics, therapeutics, and prognosis-based therapies, Precision Theranostics enables healthcare providers to deliver timely diagnoses and interventions, ultimately improving survival rates and preventing the progression of chronic and fatal conditions.
Operator of a 3D printing and bioprinting platform intended to accelerate the development of tissue models for drug screening and regenerative medicine. The company's platform provides high-throughput manufacturing of advanced biomedical devices, cell matrices, and precision human tissues for cell culture, drug screening, therapeutics, and regenerative medicine, enabling customers with transformational Biofabrication systems to revolutionize healthcare innovations related to regenerative medicine, drug discovery, and biomedical research.
CellDrop Biosciences, established in 2017 and based in Laramie, Wyoming, specializes in hydrogel-based technology for point-of-care diagnostics and targeted biomaterial delivery. The company focuses on developing hydrogel platforms that enable precise control over chemical and biological systems. Its innovations aim to facilitate the healing of equine musculoskeletal injuries efficiently, while also minimizing the risk of re-injury. By providing effective diagnostic and treatment solutions, CellDrop Biosciences addresses critical needs within the veterinary medical community.
CelluDot is a biopolymer company that is working to solve the problem of agrochemical drift. The company was founded in 2020 and is headquartered in Fayetteville, Arkansas.
Carrisan Technologies is a food technology company established in 2019 and located in Davis, California. The company specializes in developing innovative antimicrobial solutions aimed at preventing the spread of foodborne illnesses and minimizing food losses. Its technology encompasses antimicrobial coatings for equipment surfaces, methods for biofilm removal, and sanitation processes for food production. Carrisan Technologies serves various sectors, including agriculture, food processing, and foodservice, providing effective measures to combat cross-contamination in these industries.
Oculogenex is a biopharmaceutical company based in La Habra, California, established in 2020. The company specializes in developing gene therapies specifically aimed at treating retinal disorders. Its innovative approach involves ocular regenerative gene therapy that protects retinal pigment epithelial cells from oxidative stress-induced damage, which is a contributing factor to macular degeneration. By focusing on these therapies, Oculogenex aims to enhance the detection and treatment of various retinal disorders, ultimately supporting researchers in advancing novel drug solutions in this critical area of healthcare.
Supremetric develops forensic applications to help with the forensic analysis of biological stains. The company was founded in 2019 and is headquartered in Glenmont, New York.
Caribou Biofuels manufactures biofuels for the conversion of biomass into fuels. The company was established in 2017 and is based in Modesto, California.
Pomodyne is a technology company based in Mountain View, California, focused on transforming fruit crop cultivation. Founded in 2019, the company employs plant biotechnology and controlled environment agriculture to tackle significant challenges such as climate change, food safety, and food security. By innovating agricultural practices, Pomodyne aims to enhance the efficiency and sustainability of the agriculture industry, ultimately contributing to a more secure food system.
Enable Therapeutics
Grant in 2021
Enable Therapeutics is a biotechnology company developing a patented drug delivery platform. The company was founded in 2020 and is headquartered in Hopedale, Massachusetts.
Canopii is a greenhouse technology company providing turn-key farms integrated with cost-effective labor automation and energy management systems to support local and sustainable production of fresh produce.
Ortuvo develops 3D printing research tools for tissue engineering and custom bio-inks for the healthcare and biotech industries. The company was founded in 2020 and is headquartered in Baltimore, Maryland.
Developer of life science platform intended to provide accurate methods to test dangerous endotoxins. The company provides advanced healthcare innovations for the detection of blood-borne pathogens, enabling physicians to develop a rapid and sensitive diagnostic for detecting bloodstream infection.
AgraFilms is a biotechnology company founded in 2019 and based in Madison, Wisconsin, focused on providing sustainable solutions to mitigate crop loss. The company specializes in biocontrol methods, utilizing an amoebic biocontrol approach to address environmental and health challenges associated with synthetic antibiotics and pesticides. By offering natural treatments, AgraFilms aims to empower farmers with effective technology to prevent agricultural diseases and control crop damage, thereby enhancing overall crop health and productivity.
Ansa Biotechnologies, Inc. is a biotechnology company based in Berkeley, California, focused on developing innovative DNA synthesis technology utilizing enzymes. Established in 2018, the company aims to improve upon traditional chemical methods of DNA synthesis that have remained largely unchanged for decades. Ansa's enzymatic approach offers significant advantages, including increased speed, accuracy, and cleanliness in the production of DNA fragments such as oligonucleotides. This technology enhances the capabilities of biological research, therapeutics, diagnostics, and biomanufacturing by enabling the synthesis of gene-length oligonucleotides. Through its advancements, Ansa Biotechnologies seeks to facilitate innovation in the fields of biological research and engineering, ultimately providing valuable services to medical researchers and contributing to the broader biotechnology landscape.
Impact Proteomics, LLC specializes in protein sample preparation, offering a range of kits and reagents designed to produce contaminant-free samples. Founded in 2017 and based in Pittsburgh, Pennsylvania, the company provides various products, including Universal Protein Extraction and Clean Kits for peptides, whole proteins, and immunoprecipitation, as well as Promtag Reversible Protein Tagging Agents and related accessories. By supplying tools for efficient protein handling, Impact Proteomics aims to enhance drug and biomarker discovery processes, allowing researchers to accelerate the development of therapeutics and diagnostics. The company's offerings are available for purchase online, reflecting its commitment to supporting the scientific community in advancing medical research.
Nabla is an autoreverse platform that enables the rapid discovery of previously unattainable protein variants with supernatural qualities.Nabla Bio makes new medicines and improve nutrition by engineering novel proteins.
Cobio Diagnostics is a biotechnology company that develops diagnostics for bacterial identification and phenotypic antibiotic resistance testing. The company was established in 2016 and is based in Golden, Colorado.
NeyroblastGX is a biotechnology company established in 2020 and based in Murrieta, California, focused on developing theranostic products aimed at treating neurodegenerative and infectious diseases. The company’s product offerings include a blood-based biomarker diagnostic for Alzheimer's, genetically engineered dendritic cells designed to eliminate custom-made human organoids for drug screening, cellular toxicity assessment, and disease pathology. Additionally, NeyroblastGX develops an oral supplement intended to enhance protective immunity, providing patients with a comprehensive portfolio of diagnostics, drugs, and therapies to combat life-threatening conditions.
DPX Technologies, founded in 2007 and based in Columbia, South Carolina, specializes in patented pipette tip technology aimed at enhancing the quality of products used in complex chemical and biological analyses. The company's innovative technology is designed for automated liquid handling systems, offering customizable solutions that simplify and automate intricate sample preparation processes. This enables scientists to efficiently implement automated solutions that can be tailored to various laboratory workflows and methods, thereby improving overall analytical performance in research and development settings.
Sunthetics specializes in developing advanced electrochemical reactors that significantly enhance the efficiency of process chemists in the pharmaceutical industry. By utilizing smart electrochemical equipment and machine-learning software, Sunthetics enables the rapid development of lead molecules, reducing the typical process development time by 90%. This innovative approach not only cuts energy consumption by 40% but also eliminates the use of toxic chemicals and waste, promoting sustainability in chemical manufacturing. While the initial focus is on pharmaceuticals, the technology has the potential to expand into other sectors such as agrochemicals and specialty chemicals, positioning Sunthetics at the forefront of the electrification movement within the chemical industry.
New Horizon Biotech specializes in biotechnology and biopharmaceutical products, focusing on optimizing supply chains and ensuring consistent quality globally at a reduced cost. The company is finalizing tests of its patented Single Use Horizontal Fermentor system (SUHF™), which is designed for single-use microbial fermentation. This innovative system is set to enhance production efficiencies and operational cost savings, offering significant advantages over traditional fermentor designs. By improving the microbial fermentation process, New Horizon Biotech aims to support the production of high-value biopharmaceuticals, including antibiotics, vaccines, and therapeutic proteins, thereby strengthening the global competitive edge of its clients.
Cartilage is a biotechnology company founded in 2019 and based in Irvine, California. It specializes in developing tissue-engineered regeneration products aimed at healing both focal and large cartilage defects. The company's innovative platform utilizes a viscous injectable to address the early signs of cartilage injury, promoting enhanced integration of the cartilage. This approach allows for effective treatment of various cartilage defects, offering patients improved healing outcomes compared to existing therapies.
BondTrue LLC is a medical device company focused on enhancing surgical accuracy through automation. The company's patented device automates the processes of surgical incisions and closures, allowing for rapid approximation and repair of surgical wounds. This innovation enables surgeons to execute clean, consistent incisions and achieve precise suturing. Recently, BondTrue received a Phase II Maryland Industrial Partnerships (MIPS) award from the Maryland Technology Enterprise Institute, which provides funding for research and development in collaboration with universities. The $100,000 grant will support the continued development of the device, following successful completion of Phase I. BondTrue plans to refine its prototype designs, which will undergo further research and testing to advance the commercialization of this medical technology.